(34813,2000957,'regulation of cyclodextrin catabolic process','P','Any process that modulates the frequency, rate or extent of cyclodextrin catabolic process.','2013-10-27','NSRP'),(34814,2000958,'negative regulation of cyclodextrin catabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of cyclodextrin catabolic process.','2013-10-27','NSRP'),(34815,2000959,'positive regulation of cyclodextrin catabolic process','P','Any process that activates or increases the frequency, rate or extent of cyclodextrin catabolic process.','2013-10-27','NSRP'),(34816,2000960,'regulation of cellooligosaccharide metabolic process','P','Any process that modulates the frequency, rate or extent of cellooligosaccharide metabolic process.','2013-10-27','NSRP'),(34817,2000961,'negative regulation of cellooligosaccharide metabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide metabolic process.','2013-10-27','NSRP'),(34818,2000962,'positive regulation of cellooligosaccharide metabolic process','P','Any process that activates or increases the frequency, rate or extent of cellooligosaccharide metabolic process.','2013-10-27','NSRP'),(34819,2000963,'regulation of cellooligosaccharide catabolic process','P','Any process that modulates the frequency, rate or extent of cellooligosaccharide catabolic process.','2013-10-27','NSRP'),(34820,2000964,'negative regulation of cellooligosaccharide catabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of cellooligosaccharide catabolic process.','2013-10-27','NSRP'),(34821,2000965,'positive regulation of cellooligosaccharide catabolic process','P','Any process that activates or increases the frequency, rate or extent of cellooligosaccharide catabolic process.','2013-10-27','NSRP'),(34822,2000966,'regulation of cell wall polysaccharide catabolic process','P','Any process that modulates the frequency, rate or extent of cell wall polysaccharide catabolic process.','2013-10-27','NSRP'),(34823,2000967,'negative regulation of cell wall polysaccharide catabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of cell wall polysaccharide catabolic process.','2013-10-27','NSRP'),(34824,2000968,'positive regulation of cell wall polysaccharide catabolic process','P','Any process that activates or increases the frequency, rate or extent of cell wall polysaccharide catabolic process.','2013-10-27','NSRP'),(34825,2000969,'positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity','P','Any process that activates or increases the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity.','2013-10-27','NSRP'),(34826,2000970,'regulation of detection of glucose','P','Any process that modulates the frequency, rate or extent of detection of glucose.','2013-10-27','NSRP'),(34827,2000971,'negative regulation of detection of glucose','P','Any process that stops, prevents or reduces the frequency, rate or extent of detection of glucose.','2013-10-27','NSRP'),(34828,2000972,'positive regulation of detection of glucose','P','Any process that activates or increases the frequency, rate or extent of detection of glucose.','2013-10-27','NSRP'),(34829,2000973,'regulation of pro-B cell differentiation','P','Any process that modulates the frequency, rate or extent of pro-B cell differentiation.','2013-10-27','NSRP'),(34830,2000974,'negative regulation of pro-B cell differentiation','P','Any process that stops, prevents or reduces the frequency, rate or extent of pro-B cell differentiation.','2013-10-27','NSRP'),(34831,2000975,'positive regulation of pro-B cell differentiation','P','Any process that activates or increases the frequency, rate or extent of pro-B cell differentiation.','2013-10-27','NSRP'),(34832,2000976,'regulation of transcription from RNA polymerase II promoter involved in detection of glucose','P','Any regulation of transcription from RNA polymerase II promoter that is involved in detection of glucose.','2013-10-27','NSRP'),(34833,2000977,'regulation of forebrain neuron differentiation','P','Any process that modulates the frequency, rate or extent of forebrain neuron differentiation.','2013-10-27','NSRP'),(34834,2000978,'negative regulation of forebrain neuron differentiation','P','Any process that stops, prevents or reduces the frequency, rate or extent of forebrain neuron differentiation.','2013-10-27','NSRP'),(34835,2000979,'positive regulation of forebrain neuron differentiation','P','Any process that activates or increases the frequency, rate or extent of forebrain neuron differentiation.','2013-10-27','NSRP'),(34836,2000980,'regulation of inner ear receptor cell differentiation','P','Any process that modulates the frequency, rate or extent of inner ear receptor cell differentiation.','2013-10-27','NSRP'),(34837,2000981,'negative regulation of inner ear receptor cell differentiation','P','Any process that stops, prevents or reduces the frequency, rate or extent of inner ear receptor cell differentiation.','2013-10-27','NSRP'),(34838,2000982,'positive regulation of inner ear receptor cell differentiation','P','Any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation.','2013-10-27','NSRP'),(34839,2000983,'regulation of ATP citrate synthase activity','P','Any process that modulates the frequency, rate or extent of ATP citrate synthase activity.','2013-10-27','NSRP'),(34840,2000984,'negative regulation of ATP citrate synthase activity','P','Any process that stops, prevents or reduces the frequency, rate or extent of ATP citrate synthase activity.','2013-10-27','NSRP'),(34841,2000985,'positive regulation of ATP citrate synthase activity','P','Any process that activates or increases the frequency, rate or extent of ATP citrate synthase activity.','2013-10-27','NSRP'),(34842,2000986,'negative regulation of behavioral fear response','P','Any process that stops, prevents or reduces the frequency, rate or extent of behavioral fear response.','2013-10-27','NSRP'),(34843,2000987,'positive regulation of behavioral fear response','P','Any process that activates or increases the frequency, rate or extent of behavioral fear response.','2013-10-27','NSRP'),(34844,2000988,'regulation of hemicellulose catabolic process','P','Any process that modulates the frequency, rate or extent of hemicellulose catabolic process.','2013-10-27','NSRP'),(34845,2000989,'negative regulation of hemicellulose catabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of hemicellulose catabolic process.','2013-10-27','NSRP'),(34846,2000990,'positive regulation of hemicellulose catabolic process','P','Any process that activates or increases the frequency, rate or extent of hemicellulose catabolic process.','2013-10-27','NSRP'),(34847,2000991,'regulation of galactomannan catabolic process','P','Any process that modulates the frequency, rate or extent of galactomannan catabolic process.','2013-10-27','NSRP'),(34848,2000992,'negative regulation of galactomannan catabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of galactomannan catabolic process.','2013-10-27','NSRP'),(34849,2000993,'positive regulation of galactomannan catabolic process','P','Any process that activates or increases the frequency, rate or extent of galactomannan catabolic process.','2013-10-27','NSRP'),(34850,2000994,'regulation of mannan catabolic process','P','Any process that modulates the frequency, rate or extent of mannan catabolic process.','2013-10-27','NSRP'),(34851,2000995,'negative regulation of mannan catabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process.','2013-10-27','NSRP'),(34852,2000996,'positive regulation of mannan catabolic process','P','Any process that activates or increases the frequency, rate or extent of mannan catabolic process.','2013-10-27','NSRP'),(34853,2000997,'regulation of cellulose catabolic process','P','Any process that modulates the frequency, rate or extent of cellulose catabolic process.','2013-10-27','NSRP'),(34854,2000998,'negative regulation of cellulose catabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of cellulose catabolic process.','2013-10-27','NSRP'),(34855,2000999,'positive regulation of cellulose catabolic process','P','Any process that activates or increases the frequency, rate or extent of cellulose catabolic process.','2013-10-27','NSRP'),(34856,2001000,'regulation of xylan catabolic process','P','Any process that modulates the frequency, rate or extent of xylan catabolic process.','2013-10-27','NSRP'),(34857,2001001,'negative regulation of xylan catabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of xylan catabolic process.','2013-10-27','NSRP'),(34858,2001002,'positive regulation of xylan catabolic process','P','Any process that activates or increases the frequency, rate or extent of xylan catabolic process.','2013-10-27','NSRP'),(34859,2001003,'regulation of pectin catabolic process','P','Any process that modulates the frequency, rate or extent of pectin catabolic process.','2013-10-27','NSRP'),(34860,2001004,'negative regulation of pectin catabolic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of pectin catabolic process.','2013-10-27','NSRP'),(34861,2001005,'positive regulation of pectin catabolic process','P','Any process that activates or increases the frequency, rate or extent of pectin catabolic process.','2013-10-27','NSRP'),(34862,2001006,'regulation of cellulose biosynthetic process','P','Any process that modulates the frequency, rate or extent of cellulose biosynthetic process.','2013-10-27','NSRP'),(34863,2001007,'negative regulation of cellulose biosynthetic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of cellulose biosynthetic process.','2013-10-27','NSRP'),(34864,2001008,'positive regulation of cellulose biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of cellulose biosynthetic process.','2013-10-27','NSRP'),(34865,2001009,'regulation of plant-type cell wall cellulose biosynthetic process','P','Any process that modulates the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process.','2013-10-27','NSRP'),(34866,2001010,'negative regulation of plant-type cell wall cellulose biosynthetic process','P','Any process that stops, prevents or reduces the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process.','2013-10-27','NSRP'),(34867,2001011,'positive regulation of plant-type cell wall cellulose biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of plant-type cell wall cellulose biosynthetic process.','2013-10-27','NSRP'),(34868,2001012,'mesenchymal cell differentiation involved in renal system development','P','The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mesenchymal cells of the renal system as it progresses from its formation to the mature state.','2013-10-27','NSRP'),(34869,2001013,'epithelial cell proliferation involved in renal tubule morphogenesis','P','Any epithelial cell proliferation that is involved in renal tubule morphogenesis.','2013-10-27','NSRP'),(34870,2001014,'regulation of skeletal muscle cell differentiation','P','Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.','2013-10-27','NSRP'),(34871,2001015,'negative regulation of skeletal muscle cell differentiation','P','Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle cell differentiation.','2013-10-27','NSRP'),(34872,2001016,'positive regulation of skeletal muscle cell differentiation','P','Any process that activates or increases the frequency, rate or extent of skeletal muscle cell differentiation.','2013-10-27','NSRP'),(34873,2001017,'regulation of retrograde axon cargo transport','P','Any process that modulates the frequency, rate or extent of retrograde axon cargo transport.','2013-10-27','NSRP'),(34874,2001018,'negative regulation of retrograde axon cargo transport','P','Any process that stops, prevents or reduces the frequency, rate or extent of retrograde axon cargo transport.','2013-10-27','NSRP'),(34875,2001019,'positive regulation of retrograde axon cargo transport','P','Any process that activates or increases the frequency, rate or extent of retrograde axon cargo transport.','2013-10-27','NSRP'),(34876,1192,'maintenance of transcriptional fidelity during DNA-dependent transcription elongation','P','Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template.','2013-10-27','NSRP'),(34877,1193,'maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter','P','Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter.','2013-10-27','NSRP'),(34878,1194,'maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter','P','Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a bacterial-type RNA polymerase promoter.','2013-10-27','NSRP'),(34879,1195,'maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter','P','Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter.','2013-10-27','NSRP'),(34880,1196,'regulation of mating-type specific transcription from RNA polymerase II promoter','P','Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(34881,1197,'positive regulation of mating-type specific transcription from RNA polymerase II promoter','P','Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(34882,1198,'negative regulation of mating-type specific transcription from RNA polymerase II promoter','P','Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(34883,1199,'metal ion regulated sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.','2013-10-27','NSRP'),(34884,1200,'metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.','2013-10-27','NSRP'),(34885,1201,'metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor that binds the core promoter proximal region in order to modulate transcription by RNA polymerase II. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.','2013-10-27','NSRP'),(34886,1202,'copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II.','2013-10-27','NSRP'),(34887,1203,'zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), in such a way that zinc ion binding regulates the activity of the transcription factor, perhaps by regulating the ability to interact selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II), or by regulating some other function of the transcription factor, in order to modulate transcription by RNAP II.','2013-10-27','NSRP'),(34888,1204,'metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity','F','Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to modulate transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.','2013-10-27','NSRP'),(34889,1205,'RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.','2013-10-27','NSRP'),(34890,1206,'RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(34891,1207,'histone displacement','P','The removal of histones, including histone dimers, from nucleosomes within chromatin.','2013-10-27','NSRP'),(34892,1208,'histone H2A-H2B dimer displacement','P','The removal of a H2A-H2B histone dimer from a nucleosome within chromatin.','2013-10-27','NSRP'),(34893,1209,'metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.','2013-10-27','NSRP'),(34894,1210,'metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a specific DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by an RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.','2013-10-27','NSRP'),(34895,1211,'copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.','2013-10-27','NSRP'),(34896,1212,'zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with zinc (Zn) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of zinc (Zn), such a way that copper ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.','2013-10-27','NSRP'),(34897,1213,'metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.','2013-10-27','NSRP'),(34898,1214,'metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) and interacting selectively and non-covalently with metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of metal ion, such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(34899,1215,'metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to activate or increase the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.','2013-10-27','NSRP'),(34900,1216,'sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(34901,1217,'sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(34902,1218,'metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with any metal ion(s) and responding, e.g. by conformational change, to changes in the cellular level of those metal ions, in such a way that metal ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase. Specific mechanisms include increasing or decreasing the ability of the transcription factor to interact selectively and non-covalently with a specific DNA sequence (for example S. cerevisiae Cup2p or the prokaryotic SmtB/ArsR family, changing the conformation of transcription factor bound DNA between the apo- and metal-bound forms of the transcription factor. Additional mechanisms may exist.','2013-10-27','NSRP'),(34903,1219,'copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with copper(I) (Cu+) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+), in such a way that copper ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase.','2013-10-27','NSRP'),(34904,1220,'cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a specific bacterial-type transcription regulatory DNA sequence and interacting selectively and non-covalently with cadmium (Cd) ion(s) and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd), in such a way that cadmium (Cd) ion binding regulates the activity of the transcription factor in order to stop, prevent, or reduce the frequency, rate or extent of cellular DNA-dependent transcription by a bacterial-type RNA polymerase.','2013-10-27','NSRP'),(34905,1221,'transcription cofactor binding','F','Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.','2013-10-27','NSRP'),(34906,1222,'transcription corepressor binding','F','Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.','2013-10-27','NSRP'),(34907,1223,'transcription coactivator binding','F','Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.','2013-10-27','NSRP'),(34908,1224,'RNA polymerase II transcription cofactor binding','F','Interacting selectively and non-covalently with a transcription cofactor for RNA polymerase II, any protein involved in regulation of transcription via protein-protein interactions with RNA polymerase II transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery of RNA polymerase II.','2013-10-27','NSRP'),(34909,1225,'RNA polymerase II transcription coactivator binding','F','Interacting selectively and non-covalently with an RNA polymerase II transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II.','2013-10-27','NSRP'),(34910,1226,'RNA polymerase II transcription corepressor binding','F','Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II.','2013-10-27','NSRP'),(34911,1227,'RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in the regulatory region for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(34912,1228,'RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.','2013-10-27','NSRP'),(34913,2195,'2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis','P','The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3\' of the anticodon) of tRNAs.','2013-10-27','NSRP'),(34914,2196,'Ser-tRNA(Ala) hydrolase activity','F','Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala).','2013-10-27','NSRP'),(34915,2197,'xanthine dehydrogenase complex','C','A homodimeric protein complex having xanthine dehydrogenase activity.','2013-10-27','NSRP'),(34916,2198,'S/G2 transition of mitotic cell cycle','P','OBSOLETE. The transition from a cell in the S phase to the G2 phase.','2013-10-27','NSRP'),(34917,2199,'zona pellucida receptor complex','C','A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction.','2013-10-27','NSRP'),(34918,2926,'tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.','P','The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine.','2013-10-27','NSRP'),(34919,2927,'archaeosine-tRNA biosynthetic process','P','The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs.','2013-10-27','NSRP'),(34920,2929,'MECO complex','C','A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II.','2013-10-27','NSRP'),(34921,2930,'trabecular meshwork development','P','The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.','2013-10-27','NSRP'),(34922,2931,'response to ischemia','P','Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.','2013-10-27','NSRP'),(34923,2932,'tendon sheath development','P','The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.','2013-10-27','NSRP'),(34924,2933,'lipid hydroxylation','P','The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid.','2013-10-27','NSRP'),(34925,2934,'desmosome organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.','2013-10-27','NSRP'),(34926,2935,'tRNA (adenine-C2-)-methyltransferase activity','F','Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5\'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA.','2013-10-27','NSRP'),(34927,2936,'bradykinin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin.','2013-10-27','NSRP'),(34928,2937,'tRNA 4-thiouridine biosynthesis','P','The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs.','2013-10-27','NSRP'),(34929,2938,'tRNA guanine ribose methylation','P','The process whereby a guanosine residue in a tRNA is methylated on the 2\'-hydroxyl group of the ribose moiety.','2013-10-27','NSRP'),(34930,2939,'tRNA N1-guanine methylation','P','The process whereby a guanine in tRNA is methylated at position N1 of the guanine.','2013-10-27','NSRP'),(34931,2940,'tRNA N2-guanine methylation','P','The process whereby a guanine in a tRNA is methylated at the N2 position of guanine.','2013-10-27','NSRP'),(34932,2941,'synoviocyte proliferation','P','The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues.','2013-10-27','NSRP'),(34933,2942,'tRNA m2,2-guanine biosynthesis','P','The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position.','2013-10-27','NSRP'),(34934,2943,'tRNA dihydrouridine synthesis','P','The process whereby a uridine in a transfer RNA is converted to dihydrouridine.','2013-10-27','NSRP'),(34935,2944,'cyclin K-CDK12 complex','C','A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.','2013-10-27','NSRP'),(34936,2945,'cyclin K-CDK13 complex','C','A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.','2013-10-27','NSRP'),(34937,2946,'tRNA C5-cytosine methylation','P','The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine.','2013-10-27','NSRP'),(34938,2947,'tumor necrosis factor receptor superfamily complex','C','A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily.','2013-10-27','NSRP'),(34939,35996,'rhabdomere microvillus','C','Thin cylindrical membrane-covered projection on the surface of a rhabdomere.','2013-10-27','NSRP'),(34940,35997,'rhabdomere microvillus membrane','C','The portion of the plasma membrane surrounding a microvillus of a rhabdomere.','2013-10-27','NSRP'),(34941,35998,'7,8-dihydroneopterin 3\'-triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3\'-triphosphate.','2013-10-27','NSRP'),(34942,35999,'tetrahydrofolate interconversion','P','The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.','2013-10-27','NSRP'),(34943,36000,'mucocyst','C','A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion.','2013-10-27','NSRP'),(34944,36001,'\'de novo\' pyridoxal 5\'-phosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyridoxal 5\'-phosphate, the active form of vitamin B6, from simpler components.','2013-10-27','NSRP'),(34945,36002,'pre-mRNA binding','F','Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.','2013-10-27','NSRP'),(34946,36003,'positive regulation of transcription from RNA polymerase II promoter in response to stress','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).','2013-10-27','NSRP'),(34947,36004,'GAF domain binding','F','Interacting selectively and non-covalently with the GAF domain of a protein.','2013-10-27','NSRP'),(34948,36005,'response to macrophage colony-stimulating factor stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus.','2013-10-27','NSRP'),(34949,36006,'cellular response to macrophage colony-stimulating factor stimulus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus.','2013-10-27','NSRP'),(34950,36007,'scintillon','C','A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen.','2013-10-27','NSRP'),(34951,36008,'sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate','P','The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate.','2013-10-27','NSRP'),(34952,36009,'protein-glutamine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine.','2013-10-27','NSRP'),(34953,36010,'protein localization to endosome','P','A process in which a protein is transported to, or maintained in, a location within an endosome.','2013-10-27','NSRP'),(34954,36011,'imaginal disc-derived leg segmentation','P','Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint.','2013-10-27','NSRP'),(34955,36012,'cyanelle inner membrane','C','The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma.','2013-10-27','NSRP'),(34956,36013,'cyanelle outer membrane','C','The outer, i.e. cytoplasm-facing, lipid bilayer of the cyanelle envelope.','2013-10-27','NSRP'),(34957,36014,'cyanelle intermembrane space','C','The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer.','2013-10-27','NSRP'),(34958,36015,'response to interleukin-3','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.','2013-10-27','NSRP'),(34959,36016,'cellular response to interleukin-3','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.','2013-10-27','NSRP'),(34960,36017,'response to erythropoietin','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis.','2013-10-27','NSRP'),(34961,36018,'cellular response to erythropoietin','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus.','2013-10-27','NSRP'),(34962,36019,'endolysosome','C','An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.','2013-10-27','NSRP'),(34963,36020,'endolysosome membrane','C','The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.','2013-10-27','NSRP'),(34964,36021,'endolysosome lumen','C','The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.','2013-10-27','NSRP'),(34965,36022,'limb joint morphogenesis','P','The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner.','2013-10-27','NSRP'),(34966,36023,'embryonic skeletal limb joint morphogenesis','P','The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.','2013-10-27','NSRP'),(34967,36024,'protein C inhibitor-TMPRSS7 complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7.','2013-10-27','NSRP'),(34968,36025,'protein C inhibitor-TMPRSS11E complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E.','2013-10-27','NSRP'),(34969,36026,'protein C inhibitor-PLAT complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator.','2013-10-27','NSRP'),(34970,36027,'protein C inhibitor-PLAU complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator.','2013-10-27','NSRP'),(34971,36028,'protein C inhibitor-thrombin complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin.','2013-10-27','NSRP'),(34972,36029,'protein C inhibitor-KLK3 complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen.','2013-10-27','NSRP'),(34973,36030,'protein C inhibitor-plasma kallikrein complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein.','2013-10-27','NSRP'),(34974,36031,'recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex','P','The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5\' end of a transcript.','2013-10-27','NSRP'),(34975,36032,'neural crest cell delamination','P','The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube.','2013-10-27','NSRP'),(34976,36033,'mediator complex binding','F','Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.','2013-10-27','NSRP'),(34977,36034,'mediator complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.','2013-10-27','NSRP'),(34978,36035,'osteoclast development','P','The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.','2013-10-27','NSRP'),(34979,36036,'cardiac neural crest cell delamination','P','The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube.','2013-10-27','NSRP'),(34980,36037,'CD8-positive, alpha-beta T cell activation','P','The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.','2013-10-27','NSRP'),(34981,36038,'TCTN-B9D complex','C','A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins.','2013-10-27','NSRP'),(34982,36039,'curcumin metabolic process','P','The chemical reactions and pathways involving the polyphenol, curcumin.','2013-10-27','NSRP'),(34983,36040,'curcumin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of the polyphenol, curcumin.','2013-10-27','NSRP'),(34984,36041,'long-chain fatty acid binding','F','Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.','2013-10-27','NSRP'),(34985,36042,'long-chain fatty acyl-CoA binding','F','Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.','2013-10-27','NSRP'),(34986,36043,'microspike','C','OBSOLETE. A dynamic, actin-rich projection extending from the surface of a migrating animal cell.','2013-10-27','NSRP'),(34987,36044,'protein malonylation','P','OBSOLETE: The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group.','2013-10-27','NSRP'),(34988,36045,'peptidyl-lysine malonylation','P','OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine.','2013-10-27','NSRP'),(34989,36046,'protein demalonylation','P','The removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide.','2013-10-27','NSRP'),(34990,36047,'peptidyl-lysine demalonylation','P','The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein.','2013-10-27','NSRP'),(34991,36048,'protein desuccinylation','P','The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein.','2013-10-27','NSRP'),(34992,36049,'peptidyl-lysine desuccinylation','P','The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein.','2013-10-27','NSRP'),(34993,36050,'peptidyl-lysine succinylation','P','The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine.','2013-10-27','NSRP'),(34994,36051,'protein localization to trailing edge','P','A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement.','2013-10-27','NSRP'),(34995,36052,'protein localization to uropod','P','A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell.','2013-10-27','NSRP'),(34996,36053,'glomerular endothelium fenestra','C','A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes.','2013-10-27','NSRP'),(34997,36054,'protein-malonyllysine demalonylase activity','F','Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide.','2013-10-27','NSRP'),(34998,36055,'protein-succinyllysine desuccinylase activity','F','Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide.','2013-10-27','NSRP'),(34999,36056,'filtration diaphragm','C','A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph.','2013-10-27','NSRP'),(35000,36057,'slit diaphragm','C','A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.','2013-10-27','NSRP'),(35001,36058,'filtration diaphragm assembly','P','The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph.','2013-10-27','NSRP'),(35002,36059,'nephrocyte diaphragm assembly','P','The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney.','2013-10-27','NSRP'),(35003,36060,'slit diaphragm assembly','P','The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.','2013-10-27','NSRP'),(35004,36061,'muscle cell chemotaxis toward tendon cell','P','The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells.','2013-10-27','NSRP'),(35005,36062,'presynaptic periactive zone','C','A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development.','2013-10-27','NSRP'),(35006,36063,'acroblast','C','A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle.','2013-10-27','NSRP'),(35007,36064,'cilium basal body','C','A membrane-tethered derivative of the centriole, and the site of assembly and remodelling of the cilium. As well as anchoring the cilium, the basal body is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.','2013-10-27','NSRP'),(35008,36065,'fucosylation','P','The covalent attachment of a fucosyl group to an acceptor molecule.','2013-10-27','NSRP'),(35009,36066,'protein O-linked fucosylation','P','The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage.','2013-10-27','NSRP'),(35010,36067,'light-dependent chlorophyll biosynthetic process','P','The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light.','2013-10-27','NSRP'),(35011,36068,'light-independent chlorophyll biosynthetic process','P','The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light.','2013-10-27','NSRP'),(35012,36069,'light-dependent bacteriochlorophyll biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants.','2013-10-27','NSRP'),(35013,36070,'light-independent bacteriochlorophyll biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants.','2013-10-27','NSRP'),(35014,36071,'N-glycan fucosylation','P','The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains.','2013-10-27','NSRP'),(35015,36072,'direct ossification','P','The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.','2013-10-27','NSRP'),(35016,36073,'perichondral ossification','P','Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage.','2013-10-27','NSRP'),(35017,36074,'metaplastic ossification','P','Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division.','2013-10-27','NSRP'),(35018,36075,'replacement ossification','P','Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation.','2013-10-27','NSRP'),(35019,36076,'ligamentous ossification','P','Ossification wherein bone tissue forms within ligamentous tissue.','2013-10-27','NSRP'),(35020,36077,'intratendonous ossification','P','Ossification wherein bone tissue forms within tendonous tissue.','2013-10-27','NSRP'),(35021,36078,'minus-end specific microtubule depolymerization','P','The removal of tubulin heterodimers from the minus end of a microtubule.','2013-10-27','NSRP'),(35022,36079,'purine nucleotide-sugar transport','P','The directed movement of a purine nucleotide-sugar into, out of or within a cell. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.','2013-10-27','NSRP'),(35023,36080,'purine nucleotide-sugar transmembrane transporter activity','F','Catalysis of the transfer of a purine nucleotide-sugar from one side of the membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.','2013-10-27','NSRP'),(35024,36081,'extracellular ammonia-gated ion channel activity','F','Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(35025,36082,'extracellular phenylacetaldehyde-gated ion channel activity','F','Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(35026,36083,'positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(35027,36084,'GDP-fucose import into endoplasmic reticulum lumen','P','The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.','2013-10-27','NSRP'),(35028,36085,'GDP-fucose import into Golgi lumen','P','The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.','2013-10-27','NSRP'),(35029,36086,'positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions.','2013-10-27','NSRP'),(35030,36087,'glutathione synthase complex','C','A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer.','2013-10-27','NSRP'),(35031,36088,'D-serine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.','2013-10-27','NSRP'),(35032,36089,'cleavage furrow formation','P','Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.','2013-10-27','NSRP'),(35033,36090,'cleavage furrow ingression','P','Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a \'purse string\' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed.','2013-10-27','NSRP'),(35034,36091,'positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.','2013-10-27','NSRP'),(35035,36092,'phosphatidylinositol-3-phosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.','2013-10-27','NSRP'),(35036,36093,'germ cell proliferation','P','The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(35037,36094,'small molecule binding','F','Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule.','2013-10-27','NSRP'),(35038,36095,'positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of invasive growth as a result of deprivation of glucose, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(35039,36096,'3\'-5\'-exoribonuclease activity involved in pre-miRNA 3\'-end processing','F','OBSOLETE. Catalysis of the sequential cleavage of mononucleotides from a free 3\' terminus of an RNA molecule that contributes to forming the mature 3\' end of a miRNA from a pre-miRNA.','2013-10-27','NSRP'),(35040,36097,'pre-miRNA 3\'-end processing','P','OBSOLETE. Any process involved in forming the mature 3\' end of a miRNA from a pre-miRNA.','2013-10-27','NSRP'),(35041,36098,'male germ-line stem cell maintenance','P','Any process involved in preventing uncommitted germ-line stem cells in the male gonad from differentiating as another cell type.','2013-10-27','NSRP'),(35042,36099,'female germ-line stem cell maintenance','P','Any process involved in preventing uncommitted germ-line stem cells in the female gonad from differentiating as another cell type.','2013-10-27','NSRP'),(35043,36100,'leukotriene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.','2013-10-27','NSRP'),(35044,36101,'leukotriene B4 catabolic process','P','The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.','2013-10-27','NSRP'),(35045,36102,'leukotriene B4 metabolic process','P','The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.','2013-10-27','NSRP'),(35046,36103,'Kdo2-lipid A metabolic process','P','The chemical reactions and pathways involving Kdo2-lipid A, a lipopolysaccharide (LPS) component.','2013-10-27','NSRP'),(35047,36104,'Kdo2-lipid A biosynthetic process','P','The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component.','2013-10-27','NSRP'),(35048,36105,'peroxisome membrane class-1 targeting sequence binding','F','Interacting selectively and non-covalently with a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner.','2013-10-27','NSRP'),(35049,36106,'peroxisome membrane class-2 targeting sequence binding','F','Interacting selectively and non-covalently with a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner.','2013-10-27','NSRP'),(35050,36107,'4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process','P','The chemical reactions and pathways involving 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N).','2013-10-27','NSRP'),(35051,36108,'4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N).','2013-10-27','NSRP'),(35052,36109,'alpha-linolenic acid metabolic process','P','The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.','2013-10-27','NSRP'),(35053,36110,'cellular response to inositol starvation','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol.','2013-10-27','NSRP'),(35054,36111,'very long-chain fatty-acyl-CoA metabolic process','P','The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.','2013-10-27','NSRP'),(35055,36112,'medium-chain fatty-acyl-CoA metabolic process','P','The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.','2013-10-27','NSRP'),(35056,36113,'very long-chain fatty-acyl-CoA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.','2013-10-27','NSRP'),(35057,36114,'medium-chain fatty-acyl-CoA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.','2013-10-27','NSRP'),(35058,36115,'fatty-acyl-CoA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.','2013-10-27','NSRP'),(35059,36116,'long-chain fatty-acyl-CoA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.','2013-10-27','NSRP'),(35060,36117,'hyaluranon cable','C','A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan.','2013-10-27','NSRP'),(35061,36118,'hyaluranon cable assembly','P','A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan.','2013-10-27','NSRP'),(35062,36119,'response to platelet-derived growth factor stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.','2013-10-27','NSRP'),(35063,36120,'cellular response to platelet-derived growth factor stimulus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.','2013-10-27','NSRP'),(35064,36121,'double-stranded DNA-dependent ATP-dependent DNA helicase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix.','2013-10-27','NSRP'),(35065,36122,'BMP binding','F','Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family.','2013-10-27','NSRP'),(35066,36123,'histone H3-K9 dimethylation','P','The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.','2013-10-27','NSRP'),(35067,36124,'histone H3-K9 trimethylation','P','The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone.','2013-10-27','NSRP'),(35068,36125,'fatty acid beta-oxidation multienzyme complex','C','A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT).','2013-10-27','NSRP'),(35069,36126,'sperm flagellum','C','A microtubule-based flagellum that is part of a sperm, a mature male germ cell that develops from a spermatid.','2013-10-27','NSRP'),(35070,36127,'3-sulfino-L-alanine binding','F','Interacting selectively and non-covalently with 3-sulfino-L-alanine (cysteine sulfinate).','2013-10-27','NSRP'),(35071,36128,'CatSper complex','C','A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits.','2013-10-27','NSRP'),(35072,36129,'negative regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide','P','Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus.','2013-10-27','NSRP'),(35073,36130,'prostaglandin H2 endoperoxidase reductase activity','F','Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).','2013-10-27','NSRP'),(35074,36131,'prostaglandin D2 11-ketoreductase activity','F','Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+.','2013-10-27','NSRP'),(35075,36132,'13-prostaglandin reductase activity','F','Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin.','2013-10-27','NSRP'),(35076,36133,'11-hydroxythromboxane B2 dehydrogenase activity','F','Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+.','2013-10-27','NSRP'),(35077,36134,'12-hydroxyheptadecatrienoic acid synthase activity','F','Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA).','2013-10-27','NSRP'),(35078,36135,'Schwann cell migration','P','The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function.','2013-10-27','NSRP'),(35079,36136,'kynurenine-oxaloacetate transaminase activity','F','Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate.','2013-10-27','NSRP'),(35080,36137,'kynurenine aminotransferase activity','F','Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid.','2013-10-27','NSRP'),(35081,36138,'peptidyl-histidine hydroxylation','P','The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine.','2013-10-27','NSRP'),(35082,36139,'peptidyl-histidine dioxygenase activity','F','Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2.','2013-10-27','NSRP'),(35083,36140,'peptidyl-asparagine 3-dioxygenase activity','F','Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2.','2013-10-27','NSRP'),(35084,36141,'L-phenylalanine-oxaloacetate transaminase activity','F','Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate.','2013-10-27','NSRP'),(35085,36142,'flagellum movement','P','The directed, self-propelled movement of a flagellum.','2013-05-06','NSRP'),(35086,36143,'kringle domain binding','F','Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors.','2013-10-27','NSRP'),(35087,36144,'regulation of flagellum beat frequency','P','Any process that modulates the frequency of flagellum movement, the directed, self-propelled movement of a cilium.','2013-05-06','NSRP'),(35088,36145,'dendritic cell homeostasis','P','The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.','2013-10-27','NSRP'),(35089,36146,'cellular response to mycotoxin','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.','2013-10-27','NSRP'),(35090,36147,'rumination','P','A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again.','2013-10-27','NSRP'),(35091,36148,'phosphatidylglycerol acyl-chain remodeling','P','Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains.','2013-10-27','NSRP'),(35092,36149,'phosphatidylinositol acyl-chain remodeling','P','Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains.','2013-10-27','NSRP'),(35093,36150,'phosphatidylserine acyl-chain remodeling','P','Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains.','2013-10-27','NSRP'),(35094,36151,'phosphatidylcholine acyl-chain remodeling','P','Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains.','2013-10-27','NSRP'),(35095,36152,'phosphatidylethanolamine acyl-chain remodeling','P','Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.','2013-10-27','NSRP'),(35096,36153,'triglyceride acyl-chain remodeling','P','Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains.','2013-10-27','NSRP'),(35097,36154,'diacylglycerol acyl-chain remodeling','P','Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains.','2013-10-27','NSRP'),(35098,36155,'acylglycerol acyl-chain remodeling','P','Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains.','2013-10-27','NSRP'),(35099,36156,'inner dynein arm','C','Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.','2013-10-27','NSRP'),(35100,36157,'outer dynein arm','C','Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.','2013-10-27','NSRP'),(35101,36158,'outer dynein arm assembly','P','The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.','2013-10-27','NSRP'),(35102,36159,'inner dynein arm assembly','P','The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.','2013-10-27','NSRP'),(35103,36160,'melanocyte-stimulating hormone secretion','P','The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation.','2013-10-27','NSRP'),(35104,36161,'calcitonin secretion','P','The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell.','2013-10-27','NSRP'),(35105,36162,'oxytocin secretion','P','The regulated release of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain, from a cell. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior.','2013-10-27','NSRP'),(35106,36163,'3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity','F','Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2.','2013-10-27','NSRP'),(35107,36164,'cell-abiotic substrate adhesion','P','The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules.','2013-10-27','NSRP'),(35108,36165,'invasive growth in response to heat','P','The growth of colonies in filamentous chains of cells as a result of an increase in temperature.','2013-10-27','NSRP'),(35109,36166,'phenotypic switching','P','A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.','2013-10-27','NSRP'),(35110,36167,'phenotypic switching in response to host','P','A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns.','2013-10-27','NSRP'),(35111,36168,'filamentous growth of a population of unicellular organisms in response to heat','P','The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature.','2013-10-27','NSRP'),(35112,36169,'3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity','F','Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2.','2013-10-27','NSRP'),(35113,36170,'filamentous growth of a population of unicellular organisms in response to starvation','P','The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.','2013-10-27','NSRP'),(35114,36171,'filamentous growth of a population of unicellular organisms in response to chemical stimulus','P','The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus.','2013-10-27','NSRP'),(35115,36172,'thiamine salvage','P','A process that generates thiamine (vitamin B1) from derivatives of it without de novo synthesis.','2013-10-27','NSRP'),(35116,36173,'thiosulfate binding','F','Interacting selectively and non-covalently with the inorganic anion thiosulfate, a sulfur oxide that has formula O3S2.','2013-10-27','NSRP'),(35117,36174,'butane monooxygenase activity','F','Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O.','2013-10-27','NSRP'),(35118,36175,'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor','F','Catalysis of the reaction: 2\'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin.','2013-10-27','NSRP'),(35119,36176,'response to neutral pH','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus.','2013-10-27','NSRP'),(35120,36177,'filamentous growth of a population of unicellular organisms in response to pH','P','The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus.','2013-10-27','NSRP'),(35121,36178,'filamentous growth of a population of unicellular organisms in response to neutral pH','P','The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus.','2013-10-27','NSRP'),(35122,36179,'osteoclast maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes.','2013-10-27','NSRP'),(35123,36180,'filamentous growth of a population of unicellular organisms in response to biotic stimulus','P','The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.','2013-10-27','NSRP'),(35124,36181,'protein localization to linear element','P','A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase.','2013-10-27','NSRP'),(35125,36182,'asperthecin metabolic process','P','The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans.','2013-10-27','NSRP'),(35126,36183,'asperthecin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans.','2013-10-27','NSRP'),(35127,36184,'asperthecin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans.','2013-10-27','NSRP'),(35128,36185,'13-lipoxin reductase activity','F','Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+.','2013-10-27','NSRP'),(35129,36186,'early phagosome membrane','C','The lipid bilayer surrounding an early phagosome.','2013-10-27','NSRP'),(35130,36187,'cell growth mode switching, budding to filamentous','P','The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans.','2013-10-27','NSRP'),(35131,36188,'abieta-7,13-dien-18-al dehydrogenase activity','F','Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+.','2013-10-27','NSRP'),(35132,36189,'abieta-7,13-diene hydroxylase activity','F','Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O.','2013-10-27','NSRP'),(35133,36190,'indole-2-monooxygenase activity','F','Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O.','2013-10-27','NSRP'),(35134,36191,'indolin-2-one monooxygenase activity','F','Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O.','2013-10-27','NSRP'),(35135,36192,'3-hydroxyindolin-2-one monooxygenase activity','F','Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O.','2013-10-27','NSRP'),(35136,36193,'2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity','F','Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O.','2013-10-27','NSRP'),(35137,36194,'muscle cell projection','C','A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.','2013-10-27','NSRP'),(35138,36195,'muscle cell projection membrane','C','The portion of the plasma membrane surrounding a muscle cell projection.','2013-10-27','NSRP'),(35139,36196,'zymosterol metabolic process','P','The chemical reactions and pathways involving zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol).','2013-10-27','NSRP'),(35140,36197,'zymosterol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol).','2013-10-27','NSRP'),(35141,36198,'dTMP salvage','P','Any process which produces dTMP, deoxyribosylthymine monophosphate (2\'-deoxyribosylthymine 5\'-phosphate) without de novo synthesis.','2013-10-27','NSRP'),(35142,36199,'cholest-4-en-3-one 26-monooxygenase activity','F','Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate.','2013-10-27','NSRP'),(35143,36200,'3-ketosteroid 9-alpha-monooxygenase activity','F','Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O.','2013-10-27','NSRP'),(35144,36201,'ent-isokaurene C2-hydroxylase activity','F','Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+.','2013-10-27','NSRP'),(35145,36202,'ent-cassa-12,15-diene 11-hydroxylase activity','F','Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O.','2013-10-27','NSRP'),(35146,36203,'taxoid 14-beta-hydroxylase activity','F','Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O.','2013-10-27','NSRP'),(35147,36204,'abieta-7,13-dien-18-ol hydroxylase activity','F','Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O.','2013-10-27','NSRP'),(35148,36205,'histone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells.','2013-10-27','NSRP'),(35149,36206,'regulation of histone gene expression','P','Any process that modulates the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene\'s coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein.','2013-10-27','NSRP'),(35150,36207,'positive regulation of histone gene expression','P','Any process that increases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene\'s coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein.','2013-10-27','NSRP'),(35151,36208,'negative regulation of histone gene expression','P','Any process that decreases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene\'s coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein.','2013-10-27','NSRP'),(35152,36209,'9beta-pimara-7,15-diene oxidase activity','F','Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 NADPH + 3 H+ = 9beta-pimara-7,15-dien-19-oate + 3 NADP+ + 4 H2O. This is a three-step reaction: (a) 9beta-pimara-7,15-diene + O2 + NADPH + H+ = 9beta-pimara-7,15-dien-19-ol + NADP+ + H2O, (b) 9beta-pimara-7,15-dien-19-ol + O2 + NADPH + H+ = 9neta-pimara-7,15-dien-19-al + NADP+ + 2 H2O, (c) 9beta-pimara-7,15-dien-19-al + O2 + NADPH + H+ = 9beta-pimara-7,15-dien-19-oate + NADP+ + H2O.','2013-10-27','NSRP'),(35153,36210,'protein modification process in other organism','P','The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).','2013-10-27','NSRP'),(35154,36211,'protein modification process','P','The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).','2013-10-27','NSRP'),(35155,36212,'contractile ring maintenance','P','The process in which the contractile ring is maintained, typically in response to an internal or external cue.','2013-10-27','NSRP'),(35156,36213,'contractile ring contraction','P','The process of an actomyosin ring getting smaller in diameter.','2013-10-27','NSRP'),(35157,36214,'contractile ring localization','P','The process in which a contractile ring is assembled and/or maintained in a specific location.','2013-10-27','NSRP'),(35158,36215,'response to stem cell factor stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus.','2013-10-27','NSRP'),(35159,36216,'cellular response to stem cell factor stimulus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus.','2013-10-27','NSRP'),(35160,36217,'dGTP diphosphatase activity','F','Catalysis of the reaction: dGTP + H2O = dGMP + diphosphate.','2013-10-27','NSRP'),(35161,36218,'dTTP diphosphatase activity','F','Catalysis of the reaction: dTTP + H2O = dTMP + diphosphate.','2013-10-27','NSRP'),(35162,36219,'GTP diphosphatase activity','F','Catalysis of the reaction: GTP + H2O = GMP + diphosphate.','2013-10-27','NSRP'),(35163,36220,'ITP diphosphatase activity','F','Catalysis of the reaction: ITP + H2O = IMP + diphosphate.','2013-10-27','NSRP'),(35164,36221,'UTP diphosphatase activity','F','Catalysis of the reaction: UTP + H2O = UMP + diphosphate.','2013-10-27','NSRP'),(35165,36222,'XTP diphosphatase activity','F','Catalysis of the reaction: XTP + H2O = xanthosine 5\'-phosphate + diphosphate.','2013-10-27','NSRP'),(35166,36223,'cellular response to adenine starvation','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine.','2013-10-27','NSRP'),(35167,36224,'pairing center','C','A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment.','2013-10-27','NSRP'),(35168,36225,'cellular response to vitamin B1 starvation','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine).','2013-10-27','NSRP'),(35169,36226,'cell cycle arrest in response to glucose starvation','P','The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of glucose.','2013-10-27','NSRP'),(35170,36227,'mitotic G2 cell cycle arrest in response to glucose starvation','P','The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose.','2013-10-27','NSRP'),(35171,36228,'protein targeting to nuclear inner membrane','P','The process of targeting a protein to, and inserting it into, the nuclear inner membrane; usually uses signals contained within the protein.','2013-10-27','NSRP'),(35172,36229,'L-glutamine import','P','The directed movement of L-glutamine, the L-enantiomer of glutamine, into a cell or organelle.','2013-10-27','NSRP'),(35173,36230,'granulocyte activation','P','The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(35174,36231,'L-threonine import','P','The directed movement of L-threonine, the L-enantiomer of threonine, into a cell or organelle.','2013-10-27','NSRP'),(35175,36232,'L-tyrosine import','P','The directed movement of L-tyrosine, the L-enantiomer of tyrosine, into a cell or organelle.','2013-10-27','NSRP'),(35176,36233,'glycine import','P','The directed movement of glycine into a cell or organelle.','2013-10-27','NSRP'),(35177,36234,'deglucuronidation','P','The removal of glucuronic acid from a conjugated substrate.','2013-10-27','NSRP'),(35178,36235,'acyl deglucuronidation','P','The removal of glucuronic acid from an acyl-glucuronide.','2013-10-27','NSRP'),(35179,36236,'acyl glucuronidation','P','The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside).','2013-10-27','NSRP'),(35180,36237,'acyl-glucuronidase activity','F','Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate.','2013-10-27','NSRP'),(35181,36238,'gallate dioxygenase activity','F','Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate.','2013-10-27','NSRP'),(35182,36239,'taxoid 7beta-hydroxylase activity','F','Catalysis of the reaction: taxusin + O2 + NADPH + H+ = 7beta-hydroxytaxusin + NADP+ + H2O.','2013-10-27','NSRP'),(35183,36240,'septal periplasm','C','The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi.','2013-10-27','NSRP'),(35184,36241,'glutamate catabolic process to 4-hydroxybutyrate','P','The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate.','2013-10-27','NSRP'),(35185,36242,'glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity','P','The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase.','2013-10-27','NSRP'),(35186,36243,'succinate-semialdehyde dehydrogenase (NADP+) activity','F','Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+.','2013-10-27','NSRP'),(35187,36244,'cellular response to neutral pH','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus.','2013-10-27','NSRP'),(35188,36245,'cellular response to menadione','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position.','2013-10-27','NSRP'),(35189,36246,'phytochelatin 2 import into vacuole','P','The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond.','2013-10-27','NSRP'),(35190,36247,'phytochelatin 3 import into vacuole','P','The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond.','2013-10-27','NSRP'),(35191,36248,'phytochelatin 4 import into vacuole','P','The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond.','2013-10-27','NSRP'),(35192,36249,'cadmium ion import into vacuole','P','The directed movement of cadmium ions into the vacuole.','2013-10-27','NSRP'),(35193,36250,'peroxisome transport along microtubule','P','The directed movement of a peroxisome along a microtubule, mediated by motor proteins.','2013-10-27','NSRP'),(35194,36251,'positive regulation of transcription from RNA polymerase II promoter in response to salt stress','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.','2013-10-27','NSRP'),(35195,36252,'positive regulation of transcription from RNA polymerase II promoter in response to menadione','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position.','2013-10-27','NSRP'),(35196,36253,'response to amiloride','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus.','2013-10-27','NSRP'),(35197,36254,'cellular response to amiloride','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus.','2013-10-27','NSRP'),(35198,36255,'response to methylamine','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus.','2013-10-27','NSRP'),(35199,36256,'cellular response to methylamine','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus.','2013-10-27','NSRP'),(35200,36257,'multivesicular body organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.','2013-10-27','NSRP'),(35201,36258,'multivesicular body assembly','P','The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.','2013-10-27','NSRP'),(35202,36259,'aerobic raffinose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen.','2013-10-27','NSRP'),(35203,36260,'RNA capping','P','The sequence of enzymatic reactions by which a cap structure is added to the 5\' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap.','2013-10-27','NSRP'),(35204,36261,'7-methylguanosine cap hypermethylation','P','Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2\' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.','2013-10-27','NSRP'),(35205,36262,'granulysin production','P','The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(35206,36263,'L-DOPA monooxygenase activity','F','Catalysis of the reaction: L-DOPA + O2 = ? + H2O. This reaction catalyzes the oxygenation of the dopamine precursor L-DOPA, to the corresponding o-quinone.','2013-10-27','NSRP'),(35207,36264,'dopamine monooxygenase activity','F','Catalysis of the reaction: dopamine + O2 = ? + H2O. This reaction catalyzes the oxygenation of dopamine to the corresponding o-quinone.','2013-10-27','NSRP'),(35208,36265,'RNA (guanine-N7)-methylation','P','The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule.','2013-10-27','NSRP'),(35209,36266,'Cdc48p-Npl4p-Vms1p AAA ATPase complex','C','A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p.','2013-10-27','NSRP'),(35210,36267,'invasive filamentous growth','P','The growth of colonies in filamentous chains of cells into a substrate.','2013-10-27','NSRP'),(35211,36268,'swimming','P','Self-propelled movement of an organism from one location to another through water, often by means of active fin movement.','2013-10-27','NSRP'),(35212,36269,'swimming behavior','P','The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.','2013-10-27','NSRP'),(35213,36270,'response to diuretic','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.','2013-10-27','NSRP'),(35214,36271,'response to methylphenidate','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.','2013-10-27','NSRP'),(35215,36272,'response to gemcitabine','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2\'-deoxycytidine having geminal fluoro substituents in the 2\'-position, and is used as a drug in the treatment of various carcinomas.','2013-10-27','NSRP'),(35216,36273,'response to statin','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus, a compound that inhibits HMG-CoA reductases.','2013-10-27','NSRP'),(35217,36274,'response to lapatinib','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.','2013-10-27','NSRP'),(35218,36275,'response to 5-fluorouracil','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.','2013-10-27','NSRP'),(35219,36276,'response to antidepressant','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.','2013-10-27','NSRP'),(35220,36277,'response to anticonvulsant','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.','2013-10-27','NSRP'),(35221,36278,'positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen.','2013-10-27','NSRP'),(35222,36279,'positive regulation of protein export from nucleus in response to glucose starvation','P','Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose.','2013-10-27','NSRP'),(35223,36280,'cellular response to L-canavanine','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group.','2013-10-27','NSRP'),(35224,36281,'coflocculation','P','The non-sexual aggregation between single-celled organisms of different species.','2013-10-27','NSRP'),(35225,36282,'coflocculation via protein-carbohydrate interaction','P','The non-sexual aggregation between single-celled organisms of different species mediated by interaction of a protein in one species and a carbohydrate in the other species. For example, coflocculation between S. pombe and E. coli is mediated by mannose residues in the yeast cell wall interacting with lectin protein in E. coli cell projections.','2013-10-27','NSRP'),(35226,36283,'positive regulation of transcription factor import into nucleus in response to oxidative stress','P','Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus under conditions of oxidative stress.','2013-10-27','NSRP'),(35227,36284,'tubulobulbar complex','C','Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes.','2013-10-27','NSRP'),(35228,36285,'SAGA complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof.','2013-10-27','NSRP'),(35229,36286,'eisosome filament','C','A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1.','2013-10-27','NSRP'),(35230,36287,'response to iloperidone','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.','2013-10-27','NSRP'),(35231,36288,'response to ximelagatran','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.','2013-10-27','NSRP'),(35232,36289,'peptidyl-serine autophosphorylation','P','The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein.','2013-10-27','NSRP'),(35233,36290,'protein trans-autophosphorylation','P','The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer.','2013-10-27','NSRP'),(35234,36291,'protein cis-autophosphorylation','P','The phosphorylation by a protein of one or more of its own amino acid residues.','2013-10-27','NSRP'),(35235,36292,'DNA rewinding','P','The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA.','2013-10-27','NSRP'),(35236,36293,'response to decreased oxygen levels','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.','2013-10-27','NSRP'),(35237,36294,'cellular response to decreased oxygen levels','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.','2013-10-27','NSRP'),(35238,36295,'cellular response to increased oxygen levels','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.','2013-10-27','NSRP'),(35239,36296,'response to increased oxygen levels','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.','2013-10-27','NSRP'),(35240,36297,'interstrand cross-link repair','P','Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.','2013-10-27','NSRP'),(35241,36298,'recombinational interstrand cross-link repair','P','Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.','2013-10-27','NSRP'),(35242,36299,'non-recombinational interstrand cross-link repair','P','Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination.','2013-10-27','NSRP'),(35243,36300,'B cell receptor internalization','P','A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell.','2013-10-27','NSRP'),(35244,36301,'macrophage colony-stimulating factor production','P','The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(35245,36302,'atrioventricular canal development','P','The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle.','2013-10-27','NSRP'),(35246,36303,'lymph vessel morphogenesis','P','The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph.','2013-10-27','NSRP'),(35247,36304,'umbilical cord morphogenesis','P','The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta.','2013-10-27','NSRP'),(35248,36305,'ameloblast differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ.','2013-10-27','NSRP'),(35249,36306,'embryonic heart tube elongation','P','The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.','2013-10-27','NSRP'),(35250,36307,'23S rRNA (adenine(2030)-N(6))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA.','2013-10-27','NSRP'),(35251,36308,'16S rRNA (guanine(1516)-N(2))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(35252,36309,'protein localization to M-band','P','Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere.','2013-10-27','NSRP'),(35253,36310,'annealing helicase activity','F','Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between strands. Often acts on ssDNA bubbles bound by replication protein A (RPA).','2013-10-27','NSRP'),(35254,36311,'chitin disaccharide deacetylase activity','F','Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate.','2013-10-27','NSRP'),(35255,36312,'phosphatidylinositol 3-kinase regulatory subunit binding','F','Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.','2013-10-27','NSRP'),(35256,36313,'phosphatidylinositol 3-kinase catalytic subunit binding','F','Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3\' position of the inositol ring.','2013-10-27','NSRP'),(35257,36314,'response to sterol','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus.','2013-10-27','NSRP'),(35258,36315,'cellular response to sterol','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus.','2013-10-27','NSRP'),(35259,36316,'SREBP-SCAP complex retention in endoplasmic reticulum','P','Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER.','2013-10-27','NSRP'),(35260,36317,'tyrosyl-RNA phosphodiesterase activity','F','Catalysis of the hydrolysis of a 5\' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5\' end of all nascent picornavirus genomes; it is cleaved from virion RNA prior to its engaging in protein synthesis.','2013-10-27','NSRP'),(35261,36318,'peptide pheromone receptor activity','F','Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity.','2013-10-27','NSRP'),(35262,36319,'mating-type M-factor pheromone receptor activity','F','Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus.','2013-10-27','NSRP'),(35263,36320,'mating-type P-factor pheromone receptor activity','F','Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus.','2013-10-27','NSRP'),(35264,36321,'ghrelin secretion','P','The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone.','2013-10-27','NSRP'),(35265,36322,'pancreatic polypeptide secretion','P','The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas.','2013-10-27','NSRP'),(35266,36323,'vascular endothelial growth factor receptor-1 signaling pathway','P','Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35267,36324,'vascular endothelial growth factor receptor-2 signaling pathway','P','Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35268,36325,'vascular endothelial growth factor receptor-3 signaling pathway','P','Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35269,36326,'VEGF-A-activated receptor activity','F','Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity.','2013-10-27','NSRP'),(35270,36327,'VEGF-B-activated receptor activity','F','Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity.','2013-10-27','NSRP'),(35271,36328,'VEGF-C-activated receptor activity','F','Combining with vascular endothelial growth factor C (VEGF-C) and transmitting the signal across the plasma membrane to initiate a change in cell activity.','2013-10-27','NSRP'),(35272,36329,'VEGF-D-activated receptor activity','F','Combining with vascular endothelial growth factor D (VEGF-D) and transmitting the signal across the plasma membrane to initiate a change in cell activity.','2013-10-27','NSRP'),(35273,36330,'VEGF-E-activated receptor activity','F','Combining with vascular endothelial growth factor E (VEGF-E) and transmitting the signal across the plasma membrane to initiate a change in cell activity.','2013-10-27','NSRP'),(35274,36331,'avascular cornea development in camera-type eye','P','The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees.','2013-10-27','NSRP'),(35275,36332,'placental growth factor-activated receptor activity','F','Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.','2013-10-27','NSRP'),(35276,36333,'hepatocyte homeostasis','P','Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules.','2013-10-27','NSRP'),(35277,36334,'epidermal stem cell homeostasis','P','Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells.','2013-10-27','NSRP'),(35278,36335,'intestinal stem cell homeostasis','P','Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.','2013-10-27','NSRP'),(35279,36336,'dendritic cell migration','P','The movement of a dendritic cell within or between different tissues and organs of the body.','2013-10-27','NSRP'),(35280,36337,'Fas signaling pathway','P','A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily.','2013-10-27','NSRP'),(35281,36338,'viral membrane','C','The lipid bilayer of a virion, a complete fully infectious extracellular virus particle.','2013-10-27','NSRP'),(35282,36339,'lymphocyte adhesion to endothelial cell of high endothelial venule','P','The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream.','2013-10-27','NSRP'),(35283,36340,'chitin-based cuticle sclerotization by biomineralization','P','The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate.','2013-10-27','NSRP'),(35284,36341,'chitin-based cuticle sclerotization by protein cross-linking','P','The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle.','2013-10-27','NSRP'),(35285,36342,'post-anal tail morphogenesis','P','The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.','2013-10-27','NSRP'),(35286,36343,'psychomotor behavior','P','The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument.','2013-10-27','NSRP'),(35287,36344,'platelet morphogenesis','P','Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.','2013-10-27','NSRP'),(35288,36345,'platelet maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.','2013-10-27','NSRP'),(35289,36346,'cellular response to L-cysteine','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration.','2013-10-27','NSRP'),(35290,36347,'glutathione import into cell','P','The directed movement of glutathione into a cell.','2013-10-27','NSRP'),(35291,36348,'hydantoin racemase activity','F','Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin.','2013-10-27','NSRP'),(35292,36349,'galactose-specific flocculation','P','The non-sexual aggregation of single-celled organisms where cell surface galactose residues mediate adhesion between cells.','2013-10-27','NSRP'),(35293,36350,'mannose-specific flocculation','P','The non-sexual aggregation of single-celled organisms where cell surface mannose residues mediate adhesion between cells.','2013-10-27','NSRP'),(35294,36351,'histone H2A-K13 ubiquitination','P','The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin.','2013-10-27','NSRP'),(35295,36352,'histone H2A-K15 ubiquitination','P','The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin.','2013-10-27','NSRP'),(35296,36353,'histone H2A-K119 monoubiquitination','P','The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.','2013-10-27','NSRP'),(35297,36354,'2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity','F','Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+.','2013-10-27','NSRP'),(35298,36355,'2-iminoacetate synthase activity','F','Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5\'-deoxyadenosine + L-methionine + acceptor + 2 H+.','2013-10-27','NSRP'),(35299,36356,'cyclic 2,3-diphosphoglycerate synthetase activity','F','Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate.','2013-10-27','NSRP'),(35300,36357,'2-phosphoglycerate kinase activity','F','Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP.','2013-10-27','NSRP'),(35301,36358,'lipoteichoic acid D-alanylation','P','The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA).','2013-10-27','NSRP'),(35302,36359,'renal potassium excretion','P','The elimination by an organism of potassium in the urine.','2013-10-27','NSRP'),(35303,36360,'sorocarp stalk morphogenesis','P','The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.','2013-10-27','NSRP'),(35304,36361,'racemase activity, acting on amino acids and derivatives','F','Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative.','2013-10-27','NSRP'),(35305,36362,'ascus membrane','C','A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi.','2013-10-27','NSRP'),(35306,36363,'transforming growth factor beta activation','P','The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms.','2013-10-27','NSRP'),(35307,36364,'transforming growth factor beta1 activation','P','The release of transforming growth factor beta1 (TGF-beta1) from its latent state.','2013-10-27','NSRP'),(35308,36365,'transforming growth factor beta2 activation','P','The release of transforming growth factor beta 2 (TGF-beta2) from its latent state.','2013-10-27','NSRP'),(35309,36366,'transforming growth factor beta3 activation','P','The release of transforming growth factor beta 3 (TGF-beta3) from its latent state.','2013-10-27','NSRP'),(35310,36367,'light adaption','P','The ability of a photoreceptor to adjust to varying levels of light.','2013-10-27','NSRP'),(35311,36368,'cone photoresponse recovery','P','The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers.','2013-10-27','NSRP'),(35312,36369,'transcription factor catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.','2013-10-27','NSRP'),(35313,36370,'D-alanyl carrier activity','F','Accepts activated D-alanine and subsequently transfers D-alanine onto a teichoic acid acceptor molecule. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into the substrate.','2013-10-27','NSRP'),(35314,36371,'protein localization to T-tubule','P','A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.','2013-10-27','NSRP'),(35315,38028,'insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade','P','The series of molecular signals generated as a consequence of the insulin receptor binding to its physiological ligand, where the signal is passed on via the phosphatidylinositol 3-kinase cascade.','2013-10-27','NSRP'),(35316,38029,'epidermal growth factor receptor signaling pathway via MAPK cascade','P','The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on via the MAPKKK cascade.','2013-10-27','NSRP'),(35317,38030,'non-canonical Wnt receptor signaling pathway via MAPK cascade','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the MAPKKK cascade.','2013-10-27','NSRP'),(35318,38031,'non-canonical Wnt receptor signaling pathway via JNK cascade','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade.','2013-10-27','NSRP'),(35319,38032,'termination of G-protein coupled receptor signaling pathway','P','The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal.','2013-10-27','NSRP'),(35320,38033,'positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway','P','A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.','2013-10-27','NSRP'),(35321,38034,'signal transduction in absence of ligand','P','A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor.','2013-10-27','NSRP'),(35322,38035,'G-protein coupled receptor signaling in absence of ligand','P','A series of molecular signals beginning with a G-protein coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G-protein coupled receptor is not bound to an agonist.','2013-10-27','NSRP'),(35323,38036,'sphingosine-1-phosphate receptor activity','F','Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein.','2013-10-27','NSRP'),(35324,38037,'G-protein coupled receptor dimeric complex','C','A protein complex that contains two G-protein coupled receptors.','2013-10-27','NSRP'),(35325,38038,'G-protein coupled receptor homodimeric complex','C','A protein complex that contains two G-protein coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.','2013-10-27','NSRP'),(35326,38039,'G-protein coupled receptor heterodimeric complex','C','A protein complex that contains two G-protein coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR.','2013-10-27','NSRP'),(35327,38040,'cross-receptor activation within G-protein coupled receptor heterodimer','P','Activation of one protomer of a G-protein coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist occupancy in one protomer of a GPCR dimer may activate the associated promoter.','2013-10-27','NSRP'),(35328,38041,'cross-receptor inhibition within G-protein coupled receptor heterodimer','P','Inhibition of one protomer of a G-protein coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit.','2013-10-27','NSRP'),(35329,38042,'dimeric G-protein coupled receptor signaling pathway','P','A series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers.','2013-10-27','NSRP'),(35330,38043,'interleukin-5-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35331,38044,'transforming growth factor-beta secretion','P','The regulated release of transforming growth factor-beta (TGF-beta) from a cell into the extracellular region. TGF-beta is mostly secreted as a large latent TGF-beta complex (LLC) containing latency-associated proteins (LAPs) derived from the N-terminal region of the TGF-beta gene product, dimeric TGF-beta and latent TGF-beta binding proteins (LTBPs).','2013-10-27','NSRP'),(35332,38045,'large latent transforming growth factor-beta complex','C','A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors.','2013-10-27','NSRP'),(35333,38046,'enkephalin receptor activity','F','Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body.','2013-10-27','NSRP'),(35334,38047,'morphine receptor activity','F','Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein.','2013-10-27','NSRP'),(35335,38048,'dynorphin receptor activity','F','Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin.','2013-10-27','NSRP'),(35336,38049,'ligand-activated RNA polymerase II transcription factor binding transcription factor activity','F','Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements.','2013-10-27','NSRP'),(35337,38050,'glucocorticoid-activated sequence-specific DNA binding RNA polymerase II transcription factor activity','F','Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.','2013-10-27','NSRP'),(35338,38051,'glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity','F','Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, glucocorticoid-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain glucocorticoid response elements.','2013-10-27','NSRP'),(35339,38052,'estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity','F','Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.','2013-10-27','NSRP'),(35340,38053,'estrogen-activated RNA polymerase II transcription factor binding transcription factor activity','F','Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, estrogen-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain estrogen response elements.','2013-10-27','NSRP'),(35341,38054,'G-protein coupled estrogen receptor activity','F','Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(35342,38055,'BMP secretion','P','The controlled release of a member of the BMP family of proteins from a cell.','2013-10-27','NSRP'),(35343,38056,'negative regulation of BMP signaling pathway by negative regulation of BMP secretion','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell.','2013-10-27','NSRP'),(35344,38057,'TNFSF11 binding','F','Interacting selectively and non-covalently with tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family.','2013-10-27','NSRP'),(35345,38058,'TNFSF11 receptor activity','F','Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function.','2013-10-27','NSRP'),(35346,38059,'IKKalpha-IKKalpha complex','C','A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits.','2013-10-27','NSRP'),(35347,38060,'nitric oxide-cGMP-mediated signaling pathway','P','Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.','2013-10-27','NSRP'),(35348,38061,'NIK/NF-kappaB cascade','P','The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. The cascade begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).','2013-10-27','NSRP'),(35349,38062,'protein tyrosine kinase collagen receptor activity','F','Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.','2013-10-27','NSRP'),(35350,38063,'collagen-activated tyrosine kinase receptor signaling pathway','P','A series of molecular signals initiated by the binding of collagen to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity. The pathway ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35351,38064,'collagen receptor activity','F','Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(35352,38065,'collagen-activated signaling pathway','P','A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35353,38066,'p38MAPK cascade','P','An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.','2013-10-27','NSRP'),(35354,38067,'MAP kinase activity involved in cell wall biogenesis','F','Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to cell wall biogenesis.','2013-10-27','NSRP'),(35355,38068,'MAP kinase kinase activity involved in cell wall biogenesis','F','Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to cell wall biogenesis.','2013-10-27','NSRP'),(35356,38069,'MAP kinase phosphatase activity involved in regulation of cell wall biogenesis','F','Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to cell wall biogenesis.','2013-10-27','NSRP'),(35357,38070,'MAP kinase kinase kinase activity involved in cell wall biogenesis','F','Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis.','2013-10-27','NSRP'),(35358,38071,'MAP kinase activity involved in conjugation with cellular fusion','F','Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion.','2013-10-27','NSRP'),(35359,38072,'MAP kinase kinase activity involved in conjugation with cellular fusion','F','Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion.','2013-10-27','NSRP'),(35360,38073,'MAP kinase kinase kinase activity involved in conjugation with cellular fusion','F','Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis.','2013-10-27','NSRP'),(35361,38074,'MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion','F','Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to conjugation with cellular fusion.','2013-10-27','NSRP'),(35362,38075,'MAP kinase activity involved in innate immune response','F','Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to an innate immune response.','2013-10-27','NSRP'),(35363,38076,'MAP kinase kinase activity involved in innate immune response','F','Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to an innate immune response.','2013-10-27','NSRP'),(35364,38077,'MAP kinase kinase kinase activity involved in innate immune response','F','Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to an innate immune response.','2013-10-27','NSRP'),(35365,38078,'MAP kinase phosphatase activity involved in regulation of innate immune response','F','Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to an innate immune response.','2013-10-27','NSRP'),(35366,38079,'MAP kinase activity involved in osmosensory signaling pathway','F','Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway.','2013-10-27','NSRP'),(35367,38080,'MAP kinase kinase activity involved in osmosensory signaling pathway','F','Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway.','2013-10-27','NSRP'),(35368,38081,'MAP kinase kinase kinase activity involved in osmosensory signaling pathway','F','Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway.','2013-10-27','NSRP'),(35369,38082,'MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway','F','Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway.','2013-10-27','NSRP'),(35370,38083,'peptidyl-tyrosine autophosphorylation','P','The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.','2013-10-27','NSRP'),(35371,38084,'vascular endothelial growth factor signaling pathway','P','A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35372,38085,'vascular endothelial growth factor binding','F','Interacting selectively and non-covalently with a vascular endothelial growth factor.','2013-10-27','NSRP'),(35373,38086,'VEGF-activated platelet-derived growth factor receptor signaling pathway','P','A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35374,38087,'VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway','P','A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35375,38088,'VEGF-activated platelet-derived growth factor receptor-beta signaling pathway','P','A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35376,38089,'positive regulation of cell migration by vascular endothelial growth factor signaling pathway','P','A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.','2013-10-27','NSRP'),(35377,38090,'positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway','P','A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.','2013-10-27','NSRP'),(35378,38091,'positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway','P','A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation.','2013-10-27','NSRP'),(35379,38092,'nodal signaling pathway','P','A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35380,38093,'Fc receptor signaling pathway','P','A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.','2013-10-27','NSRP'),(35381,38094,'Fc-gamma receptor signaling pathway','P','A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.','2013-10-27','NSRP'),(35382,38095,'Fc-epsilon receptor signaling pathway','P','A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.','2013-10-27','NSRP'),(35383,38096,'Fc-gamma receptor signaling pathway involved in phagocytosis','P','An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.','2013-10-27','NSRP'),(35384,38097,'positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway','P','An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.','2013-10-27','NSRP'),(35385,38098,'sequestering of BMP from receptor via BMP binding','P','Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor.','2013-10-27','NSRP'),(35386,38099,'nodal receptor complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals).','2013-10-27','NSRP'),(35387,38100,'nodal binding','F','Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily.','2013-10-27','NSRP'),(35388,38101,'sequestering of nodal from receptor via nodal binding','P','Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor.','2013-10-27','NSRP'),(35389,38102,'activin receptor antagonist activity','F','Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.','2013-10-27','NSRP'),(35390,38103,'activin receptor antagonist activity involved in negative regulation of nodal signaling pathway','F','Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.','2013-10-27','NSRP'),(35391,38104,'nodal receptor complex','C','A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell.','2013-10-27','NSRP'),(35392,38105,'sequestering of TGFbeta from receptor via TGFbeta binding','P','Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor.','2013-10-27','NSRP'),(35393,38106,'choriogonadotropin hormone binding','F','Interacting selectively and non-covalently with choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit.','2013-10-27','NSRP'),(35394,38107,'nodal signaling pathway involved in determination of left/right asymmetry','P','A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism\'s body plan or part of an organism with respect to the left and right halves.','2013-10-27','NSRP'),(35395,38108,'negative regulation of appetite by leptin-mediated signaling pathway','P','A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food.','2013-10-27','NSRP'),(35396,38109,'Kit signaling pathway','P','A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.','2013-10-27','NSRP'),(35397,38110,'interleukin-2-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35398,38111,'interleukin-7-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35399,38112,'interleukin-8-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-8 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35400,38113,'interleukin-9-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-9 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35401,38114,'interleukin-21-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35402,38115,'chemokine (C-C motif) ligand 19 signaling pathway','P','A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35403,38116,'chemokine (C-C motif) ligand 21 signaling pathway','P','A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35404,38117,'C-C motif chemokine 19 receptor activity','F','Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(35405,38118,'C-C chemokine receptor CCR7 signaling pathway','P','A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it\'s physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35406,38119,'CCL19-activated CCR7 signaling pathway','P','A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35407,38120,'CCL21-activated CCR7 signaling pathway','P','A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35408,38121,'C-C motif chemokine 21 receptor activity','F','Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(35409,38122,'C-C motif chemokine 5 receptor activity','F','Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(35410,38123,'toll-like receptor TLR1:TLR2 signaling pathway','P','A series of molecular signals initiated by the binding of a heterodimeric TLR1:TLR2 complex to one of it\'s physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35411,38124,'toll-like receptor TLR6:TLR2 signaling pathway','P','A series of molecular signals initiated by the binding of a heterodimeric TLR6:TLR2 complex to one of it\'s physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35412,38127,'ERBB signaling pathway','P','A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35413,38128,'ERBB2 signaling pathway','P','A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.','2013-10-27','NSRP'),(35414,38129,'ERBB3 signaling pathway','P','A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission.','2013-10-27','NSRP'),(35415,38130,'ERBB4 signaling pathway','P','A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35416,38131,'neuregulin receptor activity','F','Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(35417,38132,'neuregulin binding','F','Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors.','2013-10-27','NSRP'),(35418,38133,'ERBB2-ERBB3 signaling pathway','P','A series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission.','2013-10-27','NSRP'),(35419,38134,'ERBB2-EGFR signaling pathway','P','A series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.','2013-10-27','NSRP'),(35420,38135,'ERBB2-ERBB4 signaling pathway','P','A series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.','2013-10-27','NSRP'),(35421,38136,'ERBB3-ERBB4 signaling pathway','P','A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35422,38137,'ERBB4-EGFR signaling pathway','P','A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35423,38138,'ERBB4-ERBB4 signaling pathway','P','A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35424,38139,'ERBB4-EGFR complex','C','A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1).','2013-10-27','NSRP'),(35425,38140,'ERBB4-ERBB3 complex','C','A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission.','2013-10-27','NSRP'),(35426,38141,'ERBB4-ERBB4 complex','C','A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4).','2013-10-27','NSRP'),(35427,38142,'EGFR:ERBB2 complex','C','A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.','2013-10-27','NSRP'),(35428,38143,'ERBB3:ERBB2 complex','C','A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3.','2013-10-27','NSRP'),(35429,38144,'ERBB4:ERBB2 complex','C','A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.','2013-10-27','NSRP'),(35430,38145,'macrophage colony-stimulating factor signaling pathway','P','A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35431,38146,'chemokine (C-X-C motif) ligand 12 signaling pathway','P','A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35432,38147,'C-X-C motif chemokine 12 receptor activity','F','Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(35433,38148,'chemokine (C-C motif) ligand 2 signaling pathway','P','A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35434,38149,'C-C motif chemokine 2 receptor activity','F','Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(35435,38150,'C-C chemokine receptor CCR2 signaling pathway','P','A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it\'s physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35436,38151,'CCL2-activated CCR2 signaling pathway','P','A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35437,38152,'C-C chemokine receptor CCR4 signaling pathway','P','A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it\'s physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35438,38153,'CCL2-activated CCR4 signaling pathway','P','A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35439,38154,'interleukin-11-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-11 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35440,38155,'interleukin-23-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-23 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35441,38156,'interleukin-3-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-3 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35442,38157,'granulocyte-macrophage colony-stimulating factor signaling pathway','P','A series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors.','2013-10-27','NSRP'),(35443,38158,'granulocyte colony-stimulating factor signaling pathway','P','A series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R).','2013-10-27','NSRP'),(35444,38159,'C-X-C chemokine receptor CXCR4 signaling pathway','P','A series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it\'s physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35445,38160,'CXCL12-activated CXCR4 signaling pathway','P','A series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35446,38161,'prolactin signaling pathway','P','A series of molecular signals initiated by the binding of the peptide hormone prolactin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35447,38162,'erythropoietin-mediated signaling pathway','P','A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35448,38163,'thrombopoietin-mediated signaling pathway','P','A series of molecular signals initiated by the binding of a thrombopoietin to the thrombopoietin receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35449,38164,'thrombopoietin receptor activity','F','Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(35450,38165,'oncostatin-M-mediated signaling pathway','P','A series of molecular signals initiated by the binding of oncostatin-M (OSM) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways.','2013-10-27','NSRP'),(35451,38166,'angiotensin-mediated signaling pathway','P','The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35452,38167,'epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity','P','The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via activation of the transcription factor NF-kappaB.','2013-10-27','NSRP'),(35453,38168,'epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade','P','The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB.','2013-10-27','NSRP'),(35454,38169,'somatostatin receptor signaling pathway','P','The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35455,38170,'somatostatin signaling pathway','P','The series of molecular signals generated as a consequence of the peptide somatostatin (SST) binding to a somatostatin receptor (SSTR). The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35456,38171,'cannabinoid signaling pathway','P','The series of molecular signals generated as a consequence of a cannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.','2013-10-27','NSRP'),(35457,38172,'interleukin-33-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35458,38173,'interleukin-17A-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(35459,38174,'interleukin-17A receptor activity','F','Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(35460,38175,'negative regulation of SREBP signaling pathway in response to increased oxygen levels','P','Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels.','2013-10-27','NSRP'),(35461,38176,'positive regulation of SREBP signaling pathway in response to decreased oxygen levels','P','Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels.','2013-10-27','NSRP'),(35462,38177,'death receptor agonist activity','F','Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor.','2013-10-27','NSRP'),(35463,38178,'complement component C5a signaling pathway','P','A series of molecular signals generated as a consequence of a the C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor.','2013-10-27','NSRP'),(35464,39528,'cytoplasmic pattern recognition receptor signaling pathway in response to virus','P','Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.','2013-10-27','NSRP'),(35465,39529,'RIG-I signaling pathway','P','Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.','2013-10-27','NSRP'),(35466,39530,'MDA-5 signaling pathway','P','Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.','2013-10-27','NSRP'),(35467,39531,'regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway','P','Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm.','2013-10-27','NSRP'),(35468,39532,'negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm.','2013-10-27','NSRP'),(35469,39533,'regulation of MDA-5 signaling pathway','P','Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA.','2013-10-27','NSRP'),(35470,39534,'negative regulation of MDA-5 signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA.','2013-10-27','NSRP'),(35471,39535,'regulation of RIG-I signaling pathway','P','Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.','2013-10-27','NSRP'),(35472,39536,'negative regulation of RIG-I signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA.','2013-10-27','NSRP'),(35473,39537,'suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. This is a mechanism by which the virus evades the host innate immune response.','2013-10-27','NSRP'),(35474,39538,'suppression by virus of host RIG-I signaling pathway','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. This is a mechanism by which the virus evades the host innate immune response.','2013-10-27','NSRP'),(35475,39539,'suppression by virus of host MDA-5 signaling pathway','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. This is a mechanism by which the virus evades the host innate immune response.','2013-10-27','NSRP'),(35476,39540,'suppression by virus of host RIG-I activity','P','Any process in which a virus stops, prevents, or reduces the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.','2013-10-27','NSRP'),(35477,39541,'suppression by virus of host RIG-I via RIG-I binding','P','Any process in which a virus stops, prevents, or reduces the activity of RIG-I (also known as DDX58) by interacting selectively and non-covalently with RIG-I itself.','2013-10-27','NSRP'),(35478,39542,'suppression by virus of host RIG-I K63-linked ubiquitination','P','Any process in which a virus stops, prevents, or reduces the rate or extent of K63-linked ubiquitination of RIG-I (also known as DDX58), thereby suppressing RIG-I signal transduction. Lys63-linked ubiquitination of the N-terminal CARD domains of RIG-I is crucial for the cytosolic RIG-I signaling pathway to elicit host antiviral innate immunity.','2013-10-27','NSRP'),(35479,39543,'suppression by virus of host RIG-I activity by viral RNA 5\' processing','P','The post-transcriptional removal by a virus of the 5\' triphosphate group of their viral RNA, thereby preventing host RIG-I from recognizing viral RNA in the host cell. The intracellular pattern recognition receptor RIG-I (also known as DDX58) recognizes viral RNAs containing 5\' triphosphates; removal by the virus of the 5\'-terminal triphosphate group from their genome protects the viral RNA from RIG-recognition.','2013-10-27','NSRP'),(35480,39544,'suppression by virus of host RIG-I activity by RIG-I proteolysis','P','The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host RIG-I protein (also known as DDX58) by cleavage of peptide bonds, thereby inhibiting RIG-I signal transduction.','2013-10-27','NSRP'),(35481,39545,'suppression by virus of host MAVS activity','P','Any process in which a virus stops, prevents, or reduces the activity of MAVS (mitochondrial antiviral signaling protein), a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses.','2013-10-27','NSRP'),(35482,39546,'suppression by virus of host MAVS activity by MAVS proteolysis','P','The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling.','2013-10-27','NSRP'),(35483,39547,'suppression by virus of host TRAF activity','P','Any process in which a virus stops, prevents, or reduces the activity of a host TRAF (tumor necrosis factor receptor-associated factor) protein. TRAFs are intracellular signal transducers that lie downstream of receptors including RIG-I, MDA-5 and Toll-like receptors (TLR) and transfer the signal to other intracellular signaling components.','2013-10-27','NSRP'),(35484,39548,'suppression by virus of host IRF3 activity','P','Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.','2013-10-27','NSRP'),(35485,39549,'suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation','P','Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes.','2013-10-27','NSRP'),(35486,39550,'suppression by virus of host IRF3 activity by inhibition of DNA binding','P','Any process in which a virus stops, prevents, or reduces IRF3-dependent gene transcription, by preventing or reducing IRF3 binding to promoter sites.','2013-10-27','NSRP'),(35487,39551,'suppression by virus of host IRF3 activity by positive regulation of IRF3 catabolic process','P','Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3) by promoting the ubiquitin-dependent degradation of IRF3, mediated by the proteasome.','2013-10-27','NSRP'),(35488,39552,'RIG-I binding','F','Interacting selectively and non-covalently with RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.','2013-10-27','NSRP'),(35489,39553,'suppression by virus of host chemokine activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity.','2013-10-27','NSRP'),(35490,39554,'suppression by virus of host MDA-5 activity','P','Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.','2013-10-27','NSRP'),(35491,39555,'suppression by virus of host MDA-5 activity via MDA-5 binding','P','Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1) by interacting selectively and non-covalently with MDA-5 itself. For example, direct binding of viral proteins to the host MDA-5 protein can inhibit interaction of MDA-5 with MAVS, its downstream signaling effector.','2013-10-27','NSRP'),(35492,39556,'MDA-5 binding','F','Interacting selectively and non-covalently with MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA.','2013-10-27','NSRP'),(35493,39557,'suppression by virus of host IRF7 activity','P','Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.','2013-10-27','NSRP'),(35494,39558,'suppression by virus of host IRF7 activity by positive regulation of IRF7 sumoylation','P','Any process in which a virus stops, prevents, or reduces IRF7-dependent gene transcription, by promoting the sumoylation of IRF7, thereby disabling its activity.','2013-10-27','NSRP'),(35495,39559,'suppression by virus of host IRF7 activity by positive regulation of IRF7 catabolic process','P','Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7) by promoting the ubiquitin-dependent degradation of IRF7, mediated by the proteasome.','2013-10-27','NSRP'),(35496,39560,'suppression by virus of host IRF9 activity','P','Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes.','2013-10-27','NSRP'),(35497,39561,'suppression by virus of host IRF9 activity by positive regulation of IRF9 localization to nucleus','P','Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9) by promoting the nuclear accumulation of IRF9. For example, the reovirus mu2 protein promotes nuclear accumulation of host IRF9 by an as yet unconfirmed-mechanism.','2013-10-27','NSRP'),(35498,39562,'suppression by virus of host STAT activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT (signal transducer and activator of transcription) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.','2013-10-27','NSRP'),(35499,39563,'suppression by virus of host STAT1 activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.','2013-10-27','NSRP'),(35500,39564,'suppression by virus of host STAT2 activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.','2013-10-27','NSRP'),(35501,39565,'suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process','P','Any process in which a virus stops, prevents, or reduces the activity of host STAT1 (signal transducer and activator of transcription-1) by promoting the ubiquitin-dependent degradation of STAT1, mediated by the proteasome.','2013-10-27','NSRP'),(35502,39566,'suppression by virus of host STAT1 activity by tyrosine dephosphorylation of STAT1','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by the removal of phosphoric residues from STAT1-O-phospho-tyrosine to form STAT1-tyrosine. For example, the viral phosphatase VH1 dephosphorylates STAT1 to reverse STAT1 activation.','2013-10-27','NSRP'),(35503,39567,'suppression by virus of host STAT1 activity by negative regulation of STAT protein import into nucleus','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by retaining STAT1 in the cytoplasm, so STAT1 is unable to translocate to the nucleus to activate transcription of its target genes.','2013-10-27','NSRP'),(35504,39568,'suppression by virus of host STAT1 activity by inhibition of DNA binding','P','Any process in which a virus stops, prevents, or reduces STAT1-dependent gene transcription, by preventing STAT1 from binding to promoter sites in the nucleus.','2013-10-27','NSRP'),(35505,39569,'suppression by virus of host STAT2 activity by positive regulation of STAT2 catabolic process','P','Any process in which a virus stops, prevents, or reduces the activity of host STAT2 (signal transducer and activator of transcription-2) by promoting the ubiquitin-dependent degradation of STAT2, mediated by the proteasome.','2013-10-27','NSRP'),(35506,39570,'suppression by virus of host STAT2 activity by negative regulation of STAT protein import into nucleus','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by retaining STAT2 in the cytoplasm, so STAT2 is unable to translocate to the nucleus to activate transcription of its target genes.','2013-10-27','NSRP'),(35507,39571,'suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT1 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT1, thereby preventing STAT1 activation.','2013-10-27','NSRP'),(35508,39572,'suppression by virus of host STAT2 activity by negative regulation of STAT2 tyrosine phosphorylation','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT2 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT2, thereby preventing STAT2 activation.','2013-10-27','NSRP'),(35509,39573,'suppression by virus of host complement activation','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase.','2013-10-27','NSRP'),(35510,39574,'suppression by virus of host TYK2 activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity. TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits.','2013-10-27','NSRP'),(35511,39575,'suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2.','2013-10-27','NSRP'),(35512,39576,'suppression by virus of host JAK1 activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity. In the host, binding of a ligand to a receptor triggers activation of JAK proteins, which phosphorylate tyrosine residues on the receptor creating sites for STAT proteins to bind, which are in turn phosphorylated and activated by JAK proteins. By blocking JAK1 activity, many viruses block the host signal transduction pathway.','2013-10-27','NSRP'),(35513,39577,'suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1.','2013-10-27','NSRP'),(35514,39578,'suppression by virus of host JAK1 activity via JAK1 binding','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive.','2013-10-27','NSRP'),(35515,39579,'suppression by virus of host ISG15 activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.','2013-10-27','NSRP'),(35516,39580,'suppression by virus of host PKR activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity. Activation of PKR involves dsRNA binding followed by autophosphorylation. Phosphorylated PKR can then phosphorylate downstream targets such as the translation initiation factor eIF2 to inhibit protein synthesis. Viruses encode a number of mechanisms to inhibit the host antiviral response via PKR, including direct interaction with PKR, promoting degradation of PKR or altering the subcellular location of PKR.','2013-10-27','NSRP'),(35517,39581,'suppression by virus of host PKR activity via double-stranded RNA binding','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by interacting selectively and non-covalently with double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding.','2013-10-27','NSRP'),(35518,39582,'suppression by virus of host PKR activity by positive regulation of PKR nuclear localization','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha).','2013-10-27','NSRP'),(35519,39583,'suppression by virus of host PKR activity by positive regulation of PKR catabolic process','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes.','2013-10-27','NSRP'),(35520,39584,'suppression by virus of host protein kinase activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity.','2013-10-27','NSRP'),(35521,39585,'PKR signal transduction','P','A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR, an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation.','2013-10-27','NSRP'),(35522,39586,'modulation by virus of host PP1 activity','P','The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host\'s antiviral response.','2013-10-27','NSRP'),(35523,39587,'suppression by virus of host tetherin activity','P','Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.','2013-10-27','NSRP'),(35524,39588,'suppression by virus of host antigen processing and presentation','P','Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(35525,39589,'suppression by virus of host TAP complex','P','Any process in which a virus stops, prevents, or reduces the activity of the host TAP complex, a heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). The TAP complex functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum, where they are loaded onto the MHC class I. By inhibiting the TAP complex, the virus prevents viral particles being presented at the cell surface, and thus evades the host immune response.','2013-10-27','NSRP'),(35526,39591,'suppression by virus of host tapasin activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host tapasin (TAP binding protein/TAPBP) activity. Tapasin is a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response.','2013-10-27','NSRP'),(35527,39592,'suppression by virus of G2/M transition of host mitotic cell cycle','P','Any viral process that decreases the rate or extent of progression from G2 phase to M phase of the host mitotic cell cycle.','2013-10-27','NSRP'),(35528,39593,'suppression by virus of host exit from mitosis','P','Any viral process which decreases the rate or extent of a host cell leaving M phase of the cell cycle. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.','2013-10-27','NSRP'),(35529,39594,'endoribonuclease activity involved in viral induction of host mRNA catabolic process','F','Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA.','2013-10-27','NSRP'),(35530,39595,'induction by virus of catabolism of host mRNA','P','The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA).','2013-10-27','NSRP'),(35531,39596,'modulation by virus of host protein dephosphorylation','P','Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein.','2013-10-27','NSRP'),(35532,39597,'induction by virus of host endoribonuclease activity','P','Any viral process that activates or increases the frequency, rate or extent of host endoribonuclease activity.','2013-10-27','NSRP'),(35533,39598,'induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process','P','OBSOLETE. The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA) initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3\' end the target mRNA.','2013-10-27','NSRP'),(35534,39599,'cleavage by virus of host mRNA','P','Any process in which a host pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner by a viral endoribonuclease.','2013-10-27','NSRP'),(35535,39600,'induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process','P','The process in which a virus increases the frequency, rate or extent of the breakdown of host nuclear-transcribed mRNAs that begins with endonucleolytic cleavage (by either a host or a viral RNAse) to generate unprotected ends.','2013-10-27','NSRP'),(35536,39601,'suppression by virus of host DNA-dependent transcription, initiation','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a host DNA template.','2013-05-06','NSRP'),(35537,39602,'suppression by virus of host transcription initiation from RNA polymerase II promoter','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template.','2013-10-27','NSRP'),(35538,39603,'TBP-class protein binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter','F','Selective and non-covalent interaction of a viral protein with a member of the class of TATA-binding proteins (TBP) in the host, including any of the TBP-related factors (TRFs), which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template.','2013-10-27','NSRP'),(35539,39604,'suppression by virus of host translation','P','Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA.','2013-10-27','NSRP'),(35540,39605,'TFIIB-class transcription factor binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter','F','Selective and non-covalent interaction of a viral protein with a member of the TFIIB-class of host transcription factors, which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template.','2013-10-27','NSRP'),(35541,39606,'suppression by virus of host translation initiation','P','Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein.','2013-10-27','NSRP'),(35542,39607,'proteolysis by virus of host translation initiation factor','P','The chemical reactions and pathways performed by a virus resulting in the hydrolysis of a host translation initiation factor by cleavage of its peptide bonds.','2013-10-27','NSRP'),(35543,39608,'suppression by virus of host translation initiation factor activity by induction of host protein dephosphorylation','P','Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor by promoting dephosphorylation of a host protein.','2013-10-27','NSRP'),(35544,39611,'suppression by virus of host translation initiation factor activity','P','Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor.','2013-10-27','NSRP'),(35545,39612,'modulation by virus of host protein phosphorylation','P','Any viral process that modulates the frequency, rate or extent of phosphorylation of a host protein.','2013-10-27','NSRP'),(35546,39613,'suppression by virus of host protein phosphorylation','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of a host protein.','2013-10-27','NSRP'),(35547,39614,'induction by virus of host protein phosphorylation','P','Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of a host protein.','2013-10-27','NSRP'),(35548,39615,'T=1 icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres.','2013-10-27','NSRP'),(35549,39616,'T=2 icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers.','2013-10-27','NSRP'),(35550,39617,'T=3 icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres.','2013-10-27','NSRP'),(35551,39618,'T=pseudo3 icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres.','2013-10-27','NSRP'),(35552,39619,'T=4 icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres.','2013-10-27','NSRP'),(35553,39620,'T=7 icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres.','2013-10-27','NSRP'),(35554,39621,'T=13 icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres.','2013-10-27','NSRP'),(35555,39622,'T=16 icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres.','2013-10-27','NSRP'),(35556,39623,'T=25 icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres.','2013-10-27','NSRP'),(35557,39624,'viral outer capsid','C','The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions.','2013-10-27','NSRP'),(35558,39625,'viral inner capsid','C','The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions.','2013-10-27','NSRP'),(35559,39626,'viral intermediate capsid','C','The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions.','2013-10-27','NSRP'),(35560,39627,'T=147 icosahedral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins.','2013-10-27','NSRP'),(35561,39628,'T=169 icosahedral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins.','2013-10-27','NSRP'),(35562,39629,'T=219 icosahedral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins.','2013-10-27','NSRP'),(35563,39630,'RNA translocase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule.','2013-10-27','NSRP'),(35564,39631,'DNA translocase activity involved in viral DNA genome packaging','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid.','2013-10-27','NSRP'),(35565,39632,'RNA translocase activity involved in viral RNA genome packaging','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule, which contributes to the packaging of viral RNA into a nucleocapsid.','2013-10-27','NSRP'),(35566,39633,'killing by virus of host cells','P','Any process mediated by a virus that results in the death of cells in the host organism.','2013-10-27','NSRP'),(35567,39634,'killing by virus of host cells during superinfection exclusion','P','The viral-killing of host cells by a pre-existing virus in response to a subsequent infection of the host cell by second virus.','2013-10-27','NSRP'),(35568,39635,'suppression by virus of host peptidoglycan biosynthetic process','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls.','2013-10-27','NSRP'),(35569,39636,'suppression by virus of host cell wall biogenesis','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts.','2013-10-27','NSRP'),(35570,39637,'catabolism by virus of host DNA','P','The breakdown of host DNA, deoxyribonucleic acid, by a virus.','2013-10-27','NSRP'),(35571,39638,'virion attachment, binding to host lipopolysaccharide','F','Interacting selectively and non-covalently with lipopolysaccharide during attachment of a virion to the host cell surface. Lipopolysaccharide (LPS) is situated in the outer part of the gram-negative bacterial cell wall.','2013-10-27','NSRP'),(35572,39639,'suppression by virus of host cell lysis in response to superinfection','P','The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus.','2013-10-27','NSRP'),(35573,39640,'cytolysis by virus via suppression of host peptidoglycan biosynthetic process','P','The killing by a virus of host cell by cytolysis, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls.','2013-10-27','NSRP'),(35574,39641,'viral inner membrane','C','The lipid bilayer of a virion contained inside the protein capsid.','2013-10-27','NSRP'),(35575,39642,'virion nucleoid','C','The region of a virion in which the nucleic acid is confined.','2013-10-27','NSRP'),(35576,39643,'host cell viral nucleoid','C','The region of a host cell that contains the viral genome.','2013-10-27','NSRP'),(35577,39644,'suppression by virus of host NF-kappaB transcription factor activity','P','Any process in which a virus stops, prevents, or reduces the activity of host NF-kappaB activity.','2013-10-27','NSRP'),(35578,39645,'modulation by virus of host G1/S transition checkpoint','P','Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint.','2013-10-27','NSRP'),(35579,39646,'modulation by virus of host G0/G1 transition checkpoint','P','Any viral process that modulates the frequency, rate or extent of the host cell G0/G1 transition checkpoint.','2013-10-27','NSRP'),(35580,39647,'suppression by virus of host poly(A)-binding protein activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host poly(A)-binding protein (PABP) activity. PABP binds to the poly(A) tail of mRNA to facilitate translation.','2013-10-27','NSRP'),(35581,39648,'modulation by virus of host protein ubiquitination','P','Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein.','2013-10-27','NSRP'),(35582,39649,'modulation by virus of host ubiquitin-protein ligase activity','P','The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.','2013-10-27','NSRP'),(35583,39650,'suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host caspase activity. Caspases are cysteine-type endopeptidases which contribute to the apoptotic process.','2013-10-27','NSRP'),(35584,39651,'induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process','P','Any process in which a virus increases the frequency, rate or extent of host cysteine-type endopeptidase activity (also called caspase activity) which contributes to the apoptotic process.','2013-10-27','NSRP'),(35585,39652,'activation by virus of host NF-kappaB transcription factor activity','P','Any process in which a virus starts, promotes, or enhances the activity of the host transcription factor NF-kappaB.','2013-10-27','NSRP'),(35586,39653,'suppression by virus of host transcription','P','Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors.','2013-10-27','NSRP'),(35587,44357,'regulation of rRNA stability','P','Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs.','2013-10-27','NSRP'),(35588,44358,'envenomation resulting in hemorrhagic damage to other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism.','2013-10-27','NSRP'),(35589,44359,'modulation of molecular function in other organism','P','The process in which an organism effects a change in the function of proteins in a second organism.','2013-10-27','NSRP'),(35590,44360,'modulation of voltage-gated potassium channel activity in other organism','P','Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism.','2013-10-27','NSRP'),(35591,44361,'negative regulation of voltage-gated potassium channel activity in other organism','P','Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism.','2013-10-27','NSRP'),(35592,44362,'negative regulation of molecular function in other organism','P','Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism.','2013-10-27','NSRP'),(35593,44363,'modulation of potassium channel activity in other organism','P','Any process in which an organism effects a change in the frequency, rate or extent of the activity of a potassium channel in another organism.','2013-10-27','NSRP'),(35594,44364,'disruption of cells of other organism','P','A process in which an organism has a negative effect on the functioning of the second organism\'s cells.','2013-10-27','NSRP'),(35595,44365,'envenomation resulting in modulation of platelet aggregation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism.','2013-10-27','NSRP'),(35596,44366,'feeding on or from other organism','P','The behaviour of consuming the whole or part of another organism for the purposes of nutrition.','2013-10-27','NSRP'),(35597,44367,'feeding from tissue of other organism','P','The behaviour of consuming part of another organism for the purposes of nutrition via a particular tissue e.g. vascular tissue.','2013-10-27','NSRP'),(35598,44368,'feeding from vascular tissue of another organism','P','The behaviour of consuming part of another organism for the purposes of nutrition via a vascular tissue.','2013-10-27','NSRP'),(35599,44369,'feeding on blood of other organism','P','The behaviour of feeding on the blood of another organism via specialized mouth parts and chemical agents used to penetrate vascular structures in the skin of hosts.','2013-10-27','NSRP'),(35600,44370,'injection of substance into other organism during feeding on blood of other organism','P','The process of forcing a substance into the bloodstream of another organism, whilst feeding on blood of other organism. The substance may facilitate the feeding process, e.g. by preventing the blood from clotting.','2013-10-27','NSRP'),(35601,44371,'feeding from phloem of other organism','P','The behaviour of consuming phloem sap, usually by penetration of the phloem wall, for the purposes of nutrition.','2013-10-27','NSRP'),(35602,44372,'feeding from xylem of other organism','P','The behaviour of consuming xylem exudate from plant xylem tissue for the purposes of nutrition.','2013-10-27','NSRP'),(35603,44373,'cytokinin binding','F','Interacting selectively and non-covalently with a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators.','2013-10-27','NSRP'),(35604,44374,'sequence-specific DNA binding, bending','F','The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.','2013-10-27','NSRP'),(35605,44375,'regulation of peroxisome size','P','Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.','2013-10-27','NSRP'),(35606,44376,'RNA polymerase II complex localization to nucleus','P','The directed movement of a RNA polymerase II core complex from the cytoplasm to the nucleus.','2013-10-27','NSRP'),(35607,44377,'RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.','2013-10-27','NSRP'),(35608,44378,'non-sequence-specific DNA binding, bending','F','The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.','2013-10-27','NSRP'),(35609,44379,'protein localization to actin cortical patch','P','A process in which a protein is transported to, or maintained in, an actin cortical patch.','2013-10-27','NSRP'),(35610,44380,'protein localization to cytoskeleton','P','A process in which a protein is transported to, or maintained in, a location within the cytoskeleton.','2013-10-27','NSRP'),(35611,44381,'glucose import in response to insulin stimulus','P','The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus.','2013-10-27','NSRP'),(35612,44382,'CLRC ubiquitin ligase complex localization to heterochromatin','P','The process by which a CLRC ubiquitin ligase complex is transported to, or maintained in, heterochromatin. CLRC ubiquitin ligase complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation.','2013-10-27','NSRP'),(35613,44383,'host chromosome','C','A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell.','2013-10-27','NSRP'),(35614,44384,'host outer membrane','C','The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell.','2013-10-27','NSRP'),(35615,44385,'integral to membrane of host cell','C','Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell.','2013-10-27','NSRP'),(35616,44386,'integral to host endoplasmic reticulum membrane','C','Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell.','2013-10-27','NSRP'),(35617,44387,'negative regulation of protein kinase activity by regulation of protein phosphorylation','P','The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase.','2013-10-27','NSRP'),(35618,44388,'small protein activating enzyme binding','F','Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme.','2013-10-27','NSRP'),(35619,44389,'small conjugating protein ligase binding','F','Interacting selectively and non-covalently with a small protein ligase, such as ubiquitin-ligase.','2013-10-27','NSRP'),(35620,44390,'small protein conjugating enzyme binding','F','Interacting selectively and non-covalently with a small protein conjugating enzyme such as ubiquitin conjugating enzyme.','2013-10-27','NSRP'),(35621,44391,'ribosomal subunit','C','Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit.','2013-10-27','NSRP'),(35622,44392,'peptidyl-lysine malonylation','P','The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine.','2013-10-27','NSRP'),(35623,44393,'microspike','C','A dynamic, actin-rich projection extending from the surface of a migrating animal cell.','2013-10-27','NSRP'),(35624,44394,'protein malonylation','P','The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group.','2013-10-27','NSRP'),(35625,44395,'protein targeting to vacuolar membrane','P','The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein.','2013-10-27','NSRP'),(35626,44396,'actin cortical patch organization','P','A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis.','2013-10-27','NSRP'),(35627,44397,'actin cortical patch internalization','P','A process of actin cortical patch localization in which the patch moves from the cell surface to the inside of the cell.','2013-10-27','NSRP'),(35628,44398,'envenomation resulting in induction of edema in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the swelling of soft tissues of the bitten organism as a result of excess water accumulation.','2013-10-27','NSRP'),(35629,44458,'motile cilium assembly','P','The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function.','2013-10-27','NSRP'),(35630,44465,'modulation of sensory perception of pain in other organism','P','A process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal, in a different organism.','2013-10-27','NSRP'),(35631,44466,'glutaryl-CoA hydrolase activity','F','Catalysis of the reaction: glutaryl-CoA + H2O = CoA + glutarate.','2013-10-27','NSRP'),(35632,44467,'glial cell line-derived neurotrophic factor secretion','P','The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell line-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons.','2013-10-27','NSRP'),(35633,44468,'envenomation resulting in modulation of blood coagulation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism.','2013-10-27','NSRP'),(35634,44469,'envenomation resulting in positive regulation of blood coagulation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism.','2013-10-27','NSRP'),(35635,44470,'envenomation resulting in negative regulation of blood coagulation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of blood coagulation in the bitten organism.','2013-10-27','NSRP'),(35636,44471,'envenomation resulting in pore formation in membrane of other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the aggregation, arrangement and bonding together of a set of components to form a pore complex in a membrane of the bitten organism.','2013-10-27','NSRP'),(35637,44472,'envenomation resulting in modulation of calcium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a calcium channel in the bitten organism.','2013-10-27','NSRP'),(35638,44473,'envenomation resulting in negative regulation of calcium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism.','2013-10-27','NSRP'),(35639,44474,'envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism.','2013-10-27','NSRP'),(35640,44475,'envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a high voltage-gated calcium channel in the bitten organism.','2013-10-27','NSRP'),(35641,44476,'envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a low voltage-gated calcium channel in the bitten organism.','2013-10-27','NSRP'),(35642,44477,'envenomation resulting in negative regulation of platelet aggregation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism.','2013-10-27','NSRP'),(35643,44478,'envenomation resulting in positive regulation of platelet aggregation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of platelet aggregation in the bitten organism.','2013-10-27','NSRP'),(35644,44479,'envenomation resulting in modulation of mast cell degranulation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of blood mast cell degranulation in the bitten organism.','2013-10-27','NSRP'),(35645,44480,'envenomation resulting in positive regulation of mast cell degranulation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of blood mast cell degranulation in the bitten organism.','2013-10-27','NSRP'),(35646,44481,'envenomation resulting in proteolysis in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism.','2013-10-27','NSRP'),(35647,44482,'envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism.','2013-10-27','NSRP'),(35648,44483,'envenomation resulting in impairment of hemostasis in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the process of hemostasis - the stopping of bleeding or the arrest of the circulation to an organ or part - in the bitten organism.','2013-10-27','NSRP'),(35649,44484,'envenomation resulting in fibrinolysis in other organism','P','The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinolysis, a process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, in the bloodstream of the bitten/stung organism.','2013-10-27','NSRP'),(35650,44485,'envenomation resulting in fibrinogenolysis in other organism','P','The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism.','2013-10-27','NSRP'),(35651,44486,'modulation of transmission of nerve impulse in other organism','P','The process in which an organism effects a change in the transmission of a nerve impulse in another organism.','2013-10-27','NSRP'),(35652,44487,'envenomation resulting in modulation of transmission of nerve impulse in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the transmission of nerve impulses in the bitten organism.','2013-10-27','NSRP'),(35653,44488,'modulation of voltage-gated sodium channel activity in other organism','P','Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism.','2013-10-27','NSRP'),(35654,44489,'negative regulation of voltage-gated sodium channel activity in other organism','P','Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism.','2013-10-27','NSRP'),(35655,44490,'positive regulation of voltage-gated sodium channel activity in other organism','P','Any process that activates or increases the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism.','2013-10-27','NSRP'),(35656,44491,'positive regulation of molecular function in other organism','P','Any process that activates or increases the frequency, rate or extent of the function of proteins in a second organism.','2013-10-27','NSRP'),(35657,44492,'envenomation resulting in modulation of voltage-gated sodium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated sodium channel in the bitten organism.','2013-10-27','NSRP'),(35658,44493,'envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated sodium channel in the bitten organism.','2013-10-27','NSRP'),(35659,44494,'envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation or increase in the activity of the activity of a voltage-gated sodium channel in the bitten organism.','2013-10-27','NSRP'),(35660,44495,'modulation of blood pressure in other organism','P','A process by which one organism modulates the force with which blood travels through the circulatory system of another organism.','2013-10-27','NSRP'),(35661,44496,'negative regulation of blood pressure in other organism','P','A process by which one organism decreases the force with which blood travels through the circulatory system of another organism.','2013-10-27','NSRP'),(35662,44497,'positive regulation of blood pressure in other organism','P','A process by which one organism increases the force with which blood travels through the circulatory system of another organism.','2013-10-27','NSRP'),(35663,44498,'envenomation resulting in modulation of blood pressure in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the force with which blood travels through the circulatory system of the bitten/stung organism.','2013-10-27','NSRP'),(35664,44499,'envenomation resulting in positive regulation of blood pressure in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant increase of the force with which blood travels through the circulatory system of the bitten/stung organism.','2013-10-27','NSRP'),(35665,44500,'envenomation resulting in negative regulation of blood pressure in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant decrease of the force with which blood travels through the circulatory system of the bitten/stung organism.','2013-10-27','NSRP'),(35666,44501,'modulation of signal transduction in other organism','P','The process in which an organism effects a change in a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism.','2013-10-27','NSRP'),(35667,44502,'positive regulation of signal transduction in other organism','P','A process in which an organism activates, maintains or increases the frequency, rate or extent of a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism.','2013-10-27','NSRP'),(35668,44503,'modulation of G-protein coupled receptor activity in other organism','P','The process in which an organism effects a change in the activity of a G-protein coupled receptor in a second organism.','2013-10-27','NSRP'),(35669,44504,'modulation of receptor activity in other organism','P','The process in which an organism effects a change in the activity of a receptor in a second organism.','2013-10-27','NSRP'),(35670,44505,'positive regulation of G-protein coupled receptor activity in other organism','P','A process that activates or increases the frequency, rate or extent of the activity of a G-protein coupled receptor in a second organism.','2013-10-27','NSRP'),(35671,44506,'modulation of glucagon-like peptide receptor 1 activity in other organism','P','The process in which an organism effects a change in the activity of a glucagon-like peptide receptor 1 in a second organism.','2013-10-27','NSRP'),(35672,44507,'positive regulation of receptor activity in other organism','P','A process that activates or increases the frequency, rate or extent of the activity of a receptor in a second organism.','2013-10-27','NSRP'),(35673,44508,'glucagon-like peptide 1 receptor activity','F','Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein.','2013-10-27','NSRP'),(35674,44509,'envenomation resulting in modulation of signal transduction in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of signal transduction in the bitten organism.','2013-10-27','NSRP'),(35675,44510,'envenomation resulting in positive regulation of signal transduction in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of signal transduction in the bitten organism.','2013-10-27','NSRP'),(35676,44511,'envenomation resulting in modulation of receptor activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of receptor activity in of the bitten organism.','2013-10-27','NSRP'),(35677,44512,'envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of glucagon-like peptide receptor 1 activity in of the bitten organism.','2013-10-27','NSRP'),(35678,44513,'envenomation resulting in modulation of G-protein coupled receptor activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G-protein coupled receptor activity in of the bitten organism.','2013-10-27','NSRP'),(35679,44514,'envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G-protein coupled receptor activity in of the bitten organism.','2013-10-27','NSRP'),(35680,44515,'envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of glucagon-like peptide receptor 1 activity in of the bitten organism.','2013-10-27','NSRP'),(35681,44516,'positive regulation of glucagon-like peptide receptor 1 activity in other organism','P','A process that activates or increases the frequency, rate or extent of the activity of a glucagon-like peptide receptor 1 in a second organism.','2013-10-27','NSRP'),(35682,44517,'modulation of vasoactive intestinal polypeptide receptor activity in other organism','P','The process in which an organism effects a change in the activity of a vasoactive intestinal polypeptide receptor in a second organism.','2013-10-27','NSRP'),(35683,44518,'positive regulation of vasoactive intestinal polypeptide receptor activity in other organism','P','A process that activates or increases the frequency, rate or extent of the activity of a vasoactive intestinal polypeptide receptor in a second organism.','2013-10-27','NSRP'),(35684,44519,'envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism.','2013-10-27','NSRP'),(35685,44520,'envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism.','2013-10-27','NSRP'),(35686,44521,'envenomation resulting in muscle damage in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant muscle damage in the bitten organism.','2013-10-27','NSRP'),(35687,44522,'envenomation resulting in myocyte killing in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism.','2013-10-27','NSRP'),(35688,44523,'envenomation resulting in damage of muscle extracellular matrix in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism.','2013-10-27','NSRP'),(35689,44524,'protein sulfhydration','P','The modification of a protein amino acid by the addition of sulfur.','2013-10-27','NSRP'),(35690,44525,'peptidyl-cystine sulfhydration','P','The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide.','2013-10-27','NSRP'),(35691,44526,'formation of peptidyl-cystine persulfide by sulphur transfer from free cysteine','P','The modification of a peptidyl-cystine residue in a protein by the transfer of a sulfur atom from a free cysteine (in the process converting the free cysteine to alanine) to the peptidyl-cysteine to form peptidyl-cysteine persulfide.','2013-10-27','NSRP'),(35692,44527,'formation of peptidyl-cystine persulfide by sulphur transfer from H2S','P','The modification of a peptidyl-cystine residue in a protein by the direct addition of H2S, followed by the removal of 2 protons to form peptidyl-cysteine persulfide.','2013-10-27','NSRP'),(35693,44528,'regulation of mitochondrial mRNA stability','P','Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs.','2013-10-27','NSRP'),(35694,44529,'regulation of mitochondrial rRNA stability','P','Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs.','2013-10-27','NSRP'),(35695,44530,'supraspliceosomal complex','C','Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5\'-end capping, 3\'-end cleavage, splicing and editing.','2013-10-27','NSRP'),(35696,44531,'modulation of programmed cell death in other organism','P','A process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism.','2013-10-27','NSRP'),(35697,44532,'modulation of apoptotic process in other organism','P','A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism.','2013-10-27','NSRP'),(35698,44533,'positive regulation of apoptotic process in other organism','P','Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism.','2013-10-27','NSRP'),(35699,44534,'envenomation resulting in modulation of apoptotic process in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism.','2013-10-27','NSRP'),(35700,44535,'very-long-chain fatty acyl-CoA oxidase activity','F','Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.','2013-10-27','NSRP'),(35701,44536,'envenomation resulting in depletion of circulating fibrinogen in other organism','P','The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with a reduction in the quantity of fibrinogen found in the bloodstream of the bitten/stung organism.','2013-10-27','NSRP'),(35702,44537,'regulation of circulating fibrinogen levels','P','Any process that modulates the frequency of a reduction in the quantity of fibrinogen circulating in the bloodstream.','2013-10-27','NSRP'),(35703,44538,'host cell periphery','C','The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell.','2013-10-27','NSRP'),(35704,44539,'long-chain fatty acid import','P','The directed movement of long-chain fatty acids into a cell or organelle. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.','2013-10-27','NSRP'),(35705,44540,'L-cystine L-cysteine-lyase (deaminating)','F','Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide.','2013-10-27','NSRP'),(35706,44541,'zymogen activation in other organism','P','The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism.','2013-10-27','NSRP'),(35707,44542,'plasminogen activation in other organism','P','The chemical reactions and pathways performed by an organism resulting in the processing of inactive plasminogen to active plasmin in another organism.','2013-10-27','NSRP'),(35708,44543,'envenomation resulting in zymogen activation in other organism','P','The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the proteolytic processing of an inactive enzyme to an active form.','2013-10-27','NSRP'),(35709,44544,'envenomation resulting in plasminogen activation in other organism','P','The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.','2013-10-27','NSRP'),(35710,44545,'NSL complex','C','A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1.','2013-10-27','NSRP'),(35711,44546,'NLRP3 inflammasome complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell.','2013-10-27','NSRP'),(35712,44547,'DNA topoisomerase binding','F','Interacting selectively and non-covalently with a DNA topoisomerase.','2013-10-27','NSRP'),(35713,44548,'S100 protein binding','F','Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer\'s disease, Down Syndrome and ALS.','2013-10-27','NSRP'),(35714,44549,'GTP cyclohydrolase binding','F','Interacting selectively and non-covalently with a GTP cyclohydrolase.','2013-10-27','NSRP'),(35715,44550,'secondary metabolite biosynthetic process','P','The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.','2013-10-27','NSRP'),(35716,44551,'envenomation resulting in modulation of vasodilation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant modulation of vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism.','2013-10-27','NSRP'),(35717,44552,'modulation of vasodilation in other organism','P','A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism.','2013-10-27','NSRP'),(35718,44553,'modulation of biological quality in other organism','P','Any process that modulates the frequency, rate or extent of a biological quality in another organism. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc.','2013-10-27','NSRP'),(35719,44554,'modulation of heart rate in other organism','P','Any process that modulates the frequency or rate of heart contraction of another organism.','2013-10-27','NSRP'),(35720,44555,'negative regulation of heart rate in other organism','P','Any process that stops, prevents or reduces the frequency of heart contraction of another organism.','2013-10-27','NSRP'),(35721,44556,'envenomation resulting in negative regulation of heart rate of other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism.','2013-10-27','NSRP'),(35722,44557,'relaxation of smooth muscle','P','A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length.','2013-10-27','NSRP'),(35723,44558,'uterine smooth muscle relaxation','P','A process in which the extent of smooth muscle contraction is reduced in the uterus.','2013-10-27','NSRP'),(35724,44559,'envenomation resulting in modulation of voltage-gated potassium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism.','2013-10-27','NSRP'),(35725,44560,'envenomation resulting in modulation of ion channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an ion channel in the bitten organism.','2013-10-27','NSRP'),(35726,44561,'modulation of ion channel activity in other organism','P','Any process in which an organism effects a change in the frequency, rate or extent of the activity of an ion channel in another organism.','2013-10-27','NSRP'),(35727,44562,'envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism.','2013-10-27','NSRP'),(35728,44563,'envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism.','2013-10-27','NSRP'),(35729,44564,'envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore\'s activity, in the bitten/stung organism.','2013-10-27','NSRP'),(35730,44565,'dendritic cell proliferation','P','The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.','2013-10-27','NSRP'),(35731,44566,'chondrocyte activation','P','A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage.','2013-10-27','NSRP'),(35732,44567,'primary cell wall cellulose synthase complex','C','A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein.','2013-10-27','NSRP'),(35733,44568,'secondary cell wall cellulose synthase complex','C','A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4.','2013-10-27','NSRP'),(35734,44569,'[Ni-Fe] hydrogenase complex','C','A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer.','2013-10-27','NSRP'),(35735,44570,'starch utilization system complex','C','A bacterial cell envelope-associated multiprotein system, which binds and degrades starch.','2013-10-27','NSRP'),(35736,44571,'[2Fe-2S] cluster assembly','P','The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.','2013-10-27','NSRP'),(35737,44572,'[4Fe-4S] cluster assembly','P','The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster.','2013-10-27','NSRP'),(35738,44573,'nitrogenase P cluster assembly','P','The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two [4Fe-4S] sub-clusters sharing a gamma-6-sulfide.','2013-10-27','NSRP'),(35739,44574,'starch utilization system complex assembly','P','The aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan.','2013-10-27','NSRP'),(35740,44575,'cellulosome assembly','P','The assembly of a cellulosome, a macromolecular multi-enzyme complex in bacteria that facilitates the breakdown of cellulase, hemicellulase and pectin in the plant cell wall.','2013-10-27','NSRP'),(35741,44576,'pentose catabolic process to ethanol','P','The anaerobic chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbons, where one of the resulting products is ethanol.','2013-10-27','NSRP'),(35742,44577,'xylose catabolic process to ethanol','P','The anaerobic chemical reactions and pathways resulting in the breakdown of xylose, an aldopentose, where one of the resulting products is ethanol.','2013-10-27','NSRP'),(35743,44578,'butyryl-CoA biosynthetic process','P','The chemical reactions and pathway resulting in the formation of butyryl-CoA.','2013-10-27','NSRP'),(35744,44579,'butyryl-CoA biosynthetic process from acetyl-CoA','P','The chemical reactions and pathway resulting in the formation of butyryl-CoA, starting from acetyl-CoA.','2013-10-27','NSRP'),(35745,44580,'butyryl-CoA catabolic process','P','The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA.','2013-10-27','NSRP'),(35746,44581,'butyryl-CoA catabolic process to butyrate','P','The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate.','2013-10-27','NSRP'),(35747,44582,'butyryl-CoA catabolic process to butanol','P','The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butanol.','2013-10-27','NSRP'),(35748,44583,'cellotriose binding','F','Interacting selectively and non-covalently with cellotriose.','2013-10-27','NSRP'),(35749,44584,'cellodextrin binding','F','Interacting selectively and non-covalently with cellodextrin, a glucose polymer of 2 or more glucose monomers.','2013-10-27','NSRP'),(35750,44585,'cellobiose binding','F','Interacting selectively and non-covalently with cellobiose, a disaccharide that represents the basic repeating unit of cellulose.','2013-10-27','NSRP'),(35751,44586,'cellotetraose binding','F','Interacting selectively and non-covalently with cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose.','2013-10-27','NSRP'),(35752,44587,'cellopentaose binding','F','Interacting selectively and non-covalently with cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose.','2013-10-27','NSRP'),(35753,44588,'laminaribiose binding','F','Interacting selectively and non-covalently with laminaribiose, a disaccharide.','2013-10-27','NSRP'),(35754,44589,'pectin binding','F','Interacting selectively and non-covalently with pectin.','2013-10-27','NSRP'),(35755,44590,'iron-sulfur-molybdenum cofactor binding','F','Interacting selectively and non-covalently with iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase.','2013-10-27','NSRP'),(35756,44591,'response to amylopectin','P','A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of amylopectin stimulus.','2013-10-27','NSRP'),(35757,44592,'response to pullulan','P','A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of pullulan stimulus.','2013-10-27','NSRP'),(35758,44593,'iron-sulfur-molybdenum cofactor assembly','P','The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase.','2013-10-27','NSRP'),(35759,44594,'17-beta-hydroxysteroid dehydrogenase (NAD+) activity','F','Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+.','2013-10-27','NSRP'),(35760,44595,'decaprenyldihydroxybenzoate methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate.','2013-10-27','NSRP'),(35761,44596,'3-demethylubiquinone-10 3-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-10 = S-adenosyl-L-homocysteine + ubiquinone-10.','2013-10-27','NSRP'),(35762,44597,'daunorubicin metabolic process','P','The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer.','2013-10-27','NSRP'),(35763,44598,'doxorubicin metabolic process','P','The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy.','2013-10-27','NSRP'),(35764,44599,'AP-5 adaptor complex','C','An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo.','2013-10-27','NSRP'),(35765,44600,'protein guanylyltransferase activity','F','Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5\'-monophosphate; GMP group) to specific residues of target proteins.','2013-10-27','NSRP'),(35766,44601,'protein denucleotidylation','P','The removal of a nucleotide from a protein amino acid.','2013-10-27','NSRP'),(35767,44602,'protein deadenylylation','P','The removal of an adenylyl group (adenosine 5\'-monophosphate; AMP) from a protein amino acid.','2013-10-27','NSRP'),(35768,44603,'protein adenylylhydrolase activity','F','Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5\'-monophosphate; AMP group) from specific residues of target proteins.','2013-10-27','NSRP'),(35769,44604,'phytochelatin transmembrane transporter ATPase activity','F','Catalysis of the reaction: ATP + H2O + phytochelatin (in) = ADP + phosphate + phytochelatin (out).','2013-10-27','NSRP'),(35770,44605,'phosphocholine transferase activity','F','Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate.','2013-10-27','NSRP'),(35771,44606,'phosphocholine hydrolase activity','F','Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate.','2013-10-27','NSRP'),(35772,44607,'disruption by symbiont of host endothelial cells','P','Any process in which an organism has a negative effect on the functioning of the host\'s endothelial cells.','2013-10-27','NSRP'),(35773,44608,'peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine','P','The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester.','2013-10-27','NSRP'),(35774,44609,'DBIRD complex','C','A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD.','2013-10-27','NSRP'),(35775,44610,'FMN transmembrane transporter activity','F','Enables the directed movement of flavine mononucleotide (FMN) into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(35776,44611,'nuclear pore inner ring','C','A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical \'spokes\' around the central transport channel. A single \'spoke\', can be isolated and is sometimes referred to as the Nup170 complex.','2013-10-27','NSRP'),(35777,44612,'nuclear pore linkers','C','A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical \'spokes\' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p).','2013-10-27','NSRP'),(35778,44613,'nuclear pore central transport channel','C','The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.','2013-10-27','NSRP'),(35779,44614,'nuclear pore cytoplasmic filaments','C','Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component.','2013-10-27','NSRP'),(35780,44615,'nuclear pore nuclear basket','C','A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component.','2013-10-27','NSRP'),(35781,44616,'modulation of relaxation of muscle in other organism','P','The process in which an organism effects a change in the relaxation of muscle in a second organism.','2013-10-27','NSRP'),(35782,44617,'modulation of relaxation of smooth muscle in other organism','P','The process in which an organism effects a change in the relaxation of smooth muscle in a second organism.','2013-10-27','NSRP'),(35783,44618,'modulation of relaxation of uterine smooth muscle in other organism','P','The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism.','2013-10-27','NSRP'),(35784,44619,'positive regulation of relaxation of uterine smooth muscle in other organism','P','The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism.','2013-10-27','NSRP'),(35785,44620,'ACP phosphopantetheine attachment site binding','F','Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP).','2013-10-27','NSRP'),(35786,44621,'modulation of cell migration in other organism','P','The process in which an organism effects a change in the process of cell migration in a second organism.','2013-10-27','NSRP'),(35787,44622,'negative regulation of cell migration in other organism','P','Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism.','2013-10-27','NSRP'),(35788,44623,'positive regulation of cell migration in other organism','P','Any process that activates or increases the frequency, rate or extent of cell migration in a second organism.','2013-10-27','NSRP'),(35789,44624,'envenomation resulting in modulation of cell migration in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of cell migration in the bitten organism.','2013-10-27','NSRP'),(35790,44625,'envenomation resulting in negative regulation of cell migration in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of cell migration in the bitten organism.','2013-10-27','NSRP'),(35791,44626,'envenomation resulting in positive regulation of cell migration in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of cell migration in the bitten organism.','2013-10-27','NSRP'),(35792,44627,'modulation of complement activation, classical pathway in other organism','P','A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism.','2013-10-27','NSRP'),(35793,44628,'positive regulation of complement activation, classical pathway in other organism','P','Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway, in a different organism.','2013-10-27','NSRP'),(35794,44629,'negative regulation of complement activation, classical pathway in other organism','P','Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism.','2013-10-27','NSRP'),(35795,44630,'modulation of complement activation, lectin pathway in other organism','P','A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism.','2013-10-27','NSRP'),(35796,44631,'positive regulation of complement activation, lectin pathway in other organism','P','Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway, in a different organism.','2013-10-27','NSRP'),(35797,44632,'negative regulation of complement activation, lectin pathway in other organism','P','Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism.','2013-10-27','NSRP'),(35798,44633,'modulation of complement activation, alternative pathway in other organism','P','A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism.','2013-10-27','NSRP'),(35799,44634,'negative regulation of complement activation, alternative pathway in other organism','P','Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism.','2013-10-27','NSRP'),(35800,44635,'positive regulation of complement activation, alternative pathway in other organism','P','Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway, in a different organism.','2013-10-27','NSRP'),(35801,44636,'envenomation resulting in modulation of complement activation, classical pathway in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism.','2013-10-27','NSRP'),(35802,44637,'envenomation resulting in negative regulation of complement activation, classical pathway in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of complement activation via the classical pathway of the bitten/stung organism.','2013-10-27','NSRP'),(35803,44638,'envenomation resulting in positive regulation of complement activation, classical pathway in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism.','2013-10-27','NSRP'),(35804,44639,'envenomation resulting in modulation of complement activation, lectin pathway in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism.','2013-10-27','NSRP'),(35805,44640,'envenomation resulting in negative regulation of complement activation, lectin pathway in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the lectin pathway in the bitten/stung organism.','2013-10-27','NSRP'),(35806,44641,'envenomation resulting in positive regulation of complement activation, lectin pathway in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the lectin pathway in the bitten/stung organism.','2013-10-27','NSRP'),(35807,44642,'envenomation resulting in modulation of complement activation, alternative pathway in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the alternative pathway in the bitten/stung organism.','2013-10-27','NSRP'),(35808,44643,'envenomation resulting in positive regulation of complement activation, alternative pathway in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism.','2013-10-27','NSRP'),(35809,44644,'envenomation resulting in negative regulation of complement activation, alternative pathway in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the alternative pathway in the bitten/stung organism.','2013-10-27','NSRP'),(35810,44645,'modulation of complement activation in other organism','P','A process that modulates the frequency, rate or extent of complement activation in a different organism.','2013-10-27','NSRP'),(35811,44646,'envenomation resulting in modulation of complement activation in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation in the bitten/stung organism.','2013-10-27','NSRP'),(35812,44647,'host-symbiont tight junction','C','An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane.','2013-10-27','NSRP'),(35813,44648,'histone H3-K4 dimethylation','P','The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone.','2013-10-27','NSRP'),(35814,44649,'envenomation resulting in cytolysis in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with cytolysis in the bitten organism.','2013-10-27','NSRP'),(35815,44650,'adhesion of symbiont to host cell','P','The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly.','2013-10-27','NSRP'),(35816,44651,'adhesion of symbiont to host epithelial cell','P','The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly.','2013-10-27','NSRP'),(35817,44652,'adhesion of symbiont to host endothelial cell','P','The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly.','2013-10-27','NSRP'),(35818,44653,'dextrin alpha-glucosidase activity','F','Catalysis of the reaction: dextrin + H2O = alpha-D-glucose.','2013-10-27','NSRP'),(35819,44654,'starch alpha-glucosidase activity','F','Catalysis of the reaction: starch + H2O = alpha-D-glucose.','2013-10-27','NSRP'),(35820,44655,'phagosome reneutralization','P','Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation.','2013-10-27','NSRP'),(35821,44656,'regulation of post-lysosomal vacuole size','P','Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis.','2013-10-27','NSRP'),(35822,44657,'pore formation in membrane of other organism during symbiotic interaction','P','The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism, occurring as part of a symbiotic interaction.','2013-10-27','NSRP'),(35823,44658,'pore formation in membrane of host by symbiont','P','The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of a host organism.','2013-10-27','NSRP'),(35824,44659,'cytolysis by virus of host cell','P','The killing by a virus of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm.','2013-10-27','NSRP'),(35825,44660,'cytolysis by virus via pore formation in host cell membrane','P','The killing by a virus of a cell in its host organism by cytolysis, caused by the formation by the virus of pores in its host cell membrane.','2013-10-27','NSRP'),(35826,44661,'disruption by virus of host cell','P','A process by which a virus has a negative effect on the functioning of the host\'s cell.','2013-10-27','NSRP'),(35827,44662,'disruption by virus of host cell membrane','P','A process by which a virus has a negative effect on the functioning of the host\'s cell membrane.','2013-10-27','NSRP'),(35828,44663,'establishment or maintenance of cell type involved in phenotypic switching','P','A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns.','2013-10-27','NSRP'),(35829,44664,'reversion of cell type to default state involved in phenotypic switching','P','The cellular process of the reversion of cells to their original cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns.','2013-10-27','NSRP'),(35830,44665,'MLL1/2 complex','C','A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species.','2013-10-27','NSRP'),(35831,44666,'MLL3/4 complex','C','A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species.','2013-10-27','NSRP'),(35832,44667,'(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out).','2013-10-27','NSRP'),(35833,44668,'sodium:malonate symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in).','2013-10-27','NSRP'),(35834,44669,'sodium:galactoside symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in).','2013-10-27','NSRP'),(35835,44670,'sodium:alanine symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ alanine(out) = sodium(in) + alanine(in).','2013-10-27','NSRP'),(35836,44671,'sorocarp spore cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass).','2013-10-27','NSRP'),(35837,44672,'acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex','C','A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis.','2013-10-27','NSRP'),(35838,44673,'7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex','C','A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420.','2013-10-27','NSRP'),(35839,44674,'methyl coenzyme M reductase complex','C','A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis.','2013-10-27','NSRP'),(35840,44675,'formyl-methanofuran dehydrogenase (tungsten enzyme) complex','C','A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis.','2013-10-27','NSRP'),(35841,44676,'formyl-methanofuran dehydrogenase (molybdenum enzyme) complex','C','A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis.','2013-10-27','NSRP'),(35842,44677,'methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex','C','A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis.','2013-10-27','NSRP'),(35843,44678,'CoB-CoM heterodisulfide reductase complex','C','A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine.','2013-10-27','NSRP'),(35844,44679,'methanophenazine reducing hydrogenase complex','C','A protein complex of three polypeptides which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine.','2013-10-27','NSRP'),(35845,44680,'methylthiol:coenzyme M methyltransferase complex','C','A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis.','2013-10-27','NSRP'),(35846,44681,'sulfopyruvate decarboxylase complex','C','A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis.','2013-10-27','NSRP'),(35847,44682,'archaeal-specific GTP cyclohydrolase activity','F','Catalysis of the reaction: GTP + H2O <=> 7,8-dihydro-D-neopterin 2\',3\'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+.','2013-10-27','NSRP'),(35848,44683,'methylthiol:coenzyme M methyltransferase activity','F','Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM.','2013-10-27','NSRP'),(35849,44684,'dihydromethanopterin reductase activity','F','Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP.','2013-10-27','NSRP'),(35850,44685,'tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity','F','Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O.','2013-10-27','NSRP'),(35851,44686,'cysteate synthase activity','F','Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-.','2013-10-27','NSRP'),(35852,44687,'geranylfarnesyl diphosphate synthase activity','F','Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate.','2013-10-27','NSRP'),(35853,44688,'7,8-dihydro-D-neopterin 2\',3\'-cyclic phosphate phosphodiesterase activity','F','Catalysis of the reaction: 7,8-dihydro-D-neopterin 2\',3\'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3\'-phosphate + H+.','2013-10-27','NSRP'),(35854,44689,'7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity','F','Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + 4-hydroxyphenylpyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 5\'-deoxyadenosine + 2 L-methionine + oxalate + ammonia + 4 H+.','2013-10-27','NSRP'),(35855,44690,'methionine import','P','The directed movement of methionine into a cell or organelle.','2013-10-27','NSRP'),(35856,44691,'tooth eruption','P','The tooth development process in which the teeth enter the mouth and become visible.','2013-10-27','NSRP'),(35857,44692,'exoribonuclease activator activity','F','Increases the activity of an exoribonuclease.','2013-10-27','NSRP'),(35858,44693,'trehalose:hydrogen symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in).','2013-10-27','NSRP'),(35859,44694,'pore-mediated entry of viral genome into host cell','P','Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail.','2013-10-27','NSRP'),(35860,44695,'Dsc E3 ubiquitin ligase complex','C','An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism.','2013-10-27','NSRP'),(35861,44696,'killing by virus of host cell by post-segregational killing','P','The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes.','2013-10-27','NSRP'),(35862,44697,'HICS complex','C','A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins.','2013-10-27','NSRP'),(35863,44698,'morphogenesis of symbiont in host cell','P','The process in which a symbiont undergoes a change in shape or form, within the host\'s cell.','2013-10-27','NSRP'),(35864,44699,'single-organism process','P','A biological process that involves only one organism.','2013-10-27','NSRP'),(35865,44700,'single organism signaling','P','A signaling process occurring within a single organism.','2013-10-27','NSRP'),(35866,44701,'response to stimulus by single organism','P','OBSOLETE. A response to a stimulus that involves only one organism.','2013-10-27','NSRP'),(35867,44702,'single organism reproductive process','P','A biological process that directly contributes to the process of producing new individuals, involving a single organism.','2013-10-27','NSRP'),(35868,44703,'multi-organism reproductive process','P','A biological process that directly contributes to the process of producing new individuals, involving another organism.','2013-10-27','NSRP'),(35869,44704,'single-organism reproductive behavior','P','The specific behavior of an organism that is associated with reproduction involving a single organism.','2013-10-27','NSRP'),(35870,44705,'multi-organism reproductive behavior','P','The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species.','2013-10-27','NSRP'),(35871,44706,'multi-multicellular organism process','P','A multicellular organism process which involves another multicellular organism of the same or different species.','2013-10-27','NSRP'),(35872,44707,'single-multicellular organism process','P','A biological process occurring within a single, multicellular organism.','2013-10-27','NSRP'),(35873,44708,'single-organism behavior','P','The specific behavior of a single organism in response to external or internal stimuli.','2013-10-27','NSRP'),(35874,44710,'single-organism metabolic process','P','A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism.','2013-10-27','NSRP'),(35875,44711,'single-organism biosynthetic process','P','A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism.','2013-10-27','NSRP'),(35876,44712,'single-organism catabolic process','P','A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism.','2013-10-27','NSRP'),(35877,44713,'2-hydroxy-adenosine triphosphate pyrophosphatase activity','F','Catalysis of the reaction: 2-hydroxy-adenosine-triphosphate + H2O = 2-hydroxy-adenosine phosphate + diphosphate.','2013-10-27','NSRP'),(35878,44714,'2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity','F','Catalysis of the reaction: 2-hydroxy-(deoxy)adenosine-triphosphate + H2O = 2-hydroxy-(deoxy)adenosine phosphate + diphosphate.','2013-10-27','NSRP'),(35879,44715,'8-oxo-dGDP phosphatase activity','F','Catalysis of the reaction 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate.','2013-10-27','NSRP'),(35880,44716,'8-oxo-GDP phosphatase activity','F','Catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate.','2013-10-27','NSRP'),(35881,44717,'8-hydroxy-dADP phosphatase activity','F','Catalysis of the reaction8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate.','2013-10-27','NSRP'),(35882,44718,'siderophore transmembrane transport','P','The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(35883,44719,'regulation of imaginal disc-derived wing size','P','Any process that modulates the size of an imaginal disc-derived wing.','2013-10-27','NSRP'),(35884,44720,'negative regulation of imaginal disc-derived wing size','P','Any process that reduces the size of an imaginal disc-derived wing.','2013-10-27','NSRP'),(35885,44721,'protein import into peroxisome matrix, substrate release','P','The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane.','2013-10-27','NSRP'),(35886,44722,'renal phosphate excretion','P','The elimination by an organism of phosphate ions in the urine.','2013-10-27','NSRP'),(35887,44723,'single-organism carbohydrate metabolic process','P','The chemical reactions and pathways involving carbohydrates, occurring within a single organism.','2013-10-27','NSRP'),(35888,44724,'single-organism carbohydrate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of carbohydrates, occurring within a single organism.','2013-10-27','NSRP'),(35889,44725,'chromatin reprogramming in the zygote','P','The global reprogramming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process.','2013-10-27','NSRP'),(35890,44726,'protection of DNA demethylation of female pronucleus','P','The protection of the maternal genome from DNA demethylation in the zygote following fertilization.','2013-10-27','NSRP'),(35891,44727,'DNA demethylation of male pronucleus','P','The active DNA demethylation of the paternal genome that takes place before the first cell division.','2013-10-27','NSRP'),(35892,44728,'DNA methylation or demethylation','P','The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule.','2013-10-27','NSRP'),(35893,44729,'hemi-methylated DNA-binding','F','Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Cytosine methylation in DNA is an important mechanism for establishing stable heritable epigenetic marks.','2013-10-27','NSRP'),(35894,44730,'bone sialoprotein binding','F','Interacting selectively and non-covalently with a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin.','2013-10-27','NSRP'),(35895,44731,'Ost-alpha/Ost-beta complex','C','A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity.','2013-10-27','NSRP'),(35896,44732,'mitotic spindle pole body','C','The microtubule organizing center on a spindle that forms as part of mitosis; functionally homologous to the animal cell centrosome.','2013-10-27','NSRP'),(35897,44733,'envenomation resulting in modulation of acid-sensing ion channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an acid-sensing ion channel (ASIC) in the bitten organism.','2013-10-27','NSRP'),(35898,44734,'envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism.','2013-10-27','NSRP'),(35899,44735,'envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism.','2013-10-27','NSRP'),(35900,44736,'acid-sensing ion channel activity','F','Catalysis of the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when a an extracellular proton has been bound by the channel complex.','2013-10-27','NSRP'),(35901,44737,'modulation of acid-sensing ion channel in other organism','P','Any process in which an organism effects a change in the frequency, rate or extent of the activity of an acid-sensing ion channel (ASIC) in another organism.','2013-10-27','NSRP'),(35902,44738,'negative regulation of acid-sensing ion channel in other organism','P','Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism.','2013-10-27','NSRP'),(35903,44739,'positive regulation of acid-sensing ion channel in other organism','P','Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism.','2013-10-27','NSRP'),(35904,44740,'negative regulation of sensory perception of pain in other organism','P','A process that negatively regulates the sensory perception of pain in a different organism.','2013-10-27','NSRP'),(35905,44741,'envenomation resulting in negative regulation of sensory perception of pain in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism.','2013-10-27','NSRP'),(35906,44742,'envenomation resulting in modulation of sensory perception of pain in other organism','P','A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism.','2013-10-27','NSRP'),(35907,44743,'intracellular protein transmembrane import','P','The directed movement of proteins into an intracellular organelle, across a membrane.','2013-10-27','NSRP'),(35908,44744,'protein targeting to nucleus','P','The process of directing proteins towards the nucleus, usually using signals contained within the protein.','2013-10-27','NSRP'),(35909,44745,'amino acid transmembrane import','P','The directed movement of amino acids into a cell or organelle, across a membrane.','2013-10-27','NSRP'),(35910,44746,'amino acid transmembrane export','P','The directed movement of amino acids out of a cell or organelle across a membrane.','2013-10-27','NSRP'),(35911,44747,'mature miRNA 3\'-end processing','P','Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3\'-ends.','2013-10-27','NSRP'),(35912,44748,'3\'-5\'-exoribonuclease activity involved in mature miRNA 3\'-end processing','F','Catalysis of the sequential cleavage of mononucleotides from a free 3\' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA.','2013-10-27','NSRP'),(35913,44749,'high-affinity zinc ion transmembrane import','P','The directed, high-affinity movement of zinc (Zn) ions across a membrane into a cell or organelle. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.','2013-10-27','NSRP'),(35914,44750,'high-affinity nickel cation transmembrane transporter activity','F','Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.','2013-10-27','NSRP'),(35915,44751,'cellular response to human chorionic gonadotropin stimulus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus.','2013-10-27','NSRP'),(35916,44752,'response to human chorionic gonadotropin stimulus','P','Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus.','2013-10-27','NSRP'),(35917,44753,'amphisome','C','An autophagic vacuole formed upon fusion between autophagosomes and endosomes.','2013-10-27','NSRP'),(35918,44754,'autolysosome','C','A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases.','2013-10-27','NSRP'),(35919,44755,'pantothenate import into cell','P','The directed movement of pantothenate into a cell.','2013-10-27','NSRP'),(35920,44756,'biotin import into cell','P','The directed movement of biotin into a cell.','2013-10-27','NSRP'),(35921,44757,'dethiobiotin import into cell','P','The directed movement of dethiobiotin into a cell.','2013-10-27','NSRP'),(35922,44758,'modulation by symbiont of host synaptic transmission','P','Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism.','2013-10-27','NSRP'),(35923,44759,'negative regulation by symbiont of host synaptic transmission','P','Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism.','2013-10-27','NSRP'),(35924,44760,'modulation by symbiont of host cholinergic synaptic transmission','P','Any process in which a symbiont organism modulates the frequency, rate or extent of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism.','2013-10-27','NSRP'),(35925,44761,'negative regulation by symbiont of host cholinergic synaptic transmission','P','Any process in which a symbiont organism negatively regulates cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism.','2013-10-27','NSRP'),(35926,44762,'negative regulation by symbiont of host neurotransmitter secretion','P','Any process in which a symbiont organism negatively regulates the regulated release of a neurotransmitter from a cell in its host organism.','2013-10-27','NSRP'),(35927,44763,'single-organism cellular process','P','Any process that is carried out at the cellular level, occurring within a single organism.','2013-10-27','NSRP'),(35928,44764,'multi-organism cellular process','P','Any process that is carried out at the cellular level which involves another organism of the same or different species.','2013-10-27','NSRP'),(35929,44765,'single-organism transport','P','The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism.','2013-10-27','NSRP'),(35930,44766,'multi-organism transport','P','The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism.','2013-10-27','NSRP'),(35931,44767,'single-organism developmental process','P','A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism.','2013-10-27','NSRP'),(35932,44768,'NMS complex interaction involved in chromosome segregation','P','The interaction and association of NMS complexes required for kinetochore-spindle binding and chromosome segregation to occur.','2013-10-27','NSRP'),(35933,44769,'ATPase activity, coupled to transmembrane movement of ions, rotational mechanism','F','Catalysis of the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism.','2013-10-27','NSRP'),(35934,44770,'cell cycle phase transition','P','The cell cycle process by which a cell commits to entering the next cell cycle phase.','2013-10-27','NSRP'),(35935,44771,'meiotic cell cycle phase transition','P','The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase.','2013-10-27','NSRP'),(35936,44772,'mitotic cell cycle phase transition','P','The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.','2013-10-27','NSRP'),(35937,44773,'mitotic DNA damage checkpoint','P','A mitotic cell cycle checkpoint that detects and negatively regulates progression through the cell cycle in response to DNA damage.','2013-10-27','NSRP'),(35938,44774,'mitotic DNA integrity checkpoint','P','A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.','2013-10-27','NSRP'),(35939,44775,'DNA polymerase III, beta sliding clamp processivity factor complex','C','A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species.','2013-10-27','NSRP'),(35940,44776,'DNA polymerase III, core complex','C','The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3\'-5\' exonuclease proofreading activities.','2013-10-27','NSRP'),(35941,44777,'single-stranded DNA-binding protein complex','C','A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair.','2013-10-27','NSRP'),(35942,44778,'meiotic DNA integrity checkpoint','P','A meiotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction.','2013-10-27','NSRP'),(35943,44779,'meiotic spindle checkpoint','P','A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic nuclear division until the spindle is correctly assembled and that the chromosomes are attached to the spindle.','2013-10-27','NSRP'),(35944,52739,'phosphatidylserine 1-acylhydrolase activity','F','Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid.','2013-10-27','NSRP'),(35945,52740,'1-acyl-2-lysophosphatidylserine acylhydrolase activity','F','Catalysis of the reaction: 1-acyl-2-lysophosphatidylserine + H2O = sn-glycerol-phosphoserine + a carboxylate.','2013-10-27','NSRP'),(35946,52741,'(R)-limonene 6-monooxygenase activity','F','Catalysis of the reaction: (4R)-limonene + H+ + NADPH + O2 = (1R,5S)-carveol + H2O + NADP+.','2013-10-27','NSRP'),(35947,52742,'phosphatidylinositol kinase activity','F','Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.','2013-10-27','NSRP'),(35948,52743,'inositol tetrakisphosphate phosphatase activity','F','Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate.','2013-10-27','NSRP'),(35949,52744,'phosphatidylinositol monophosphate phosphatase activity','F','Catalysis of the reaction: phosphatidylinositol monophosphate + H2O = phosphatidylinositol + phosphate.','2013-10-27','NSRP'),(35950,52745,'inositol phosphate phosphatase activity','F','Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate.','2013-10-27','NSRP'),(35951,52746,'inositol phosphorylation','P','The process of introducing one or more phosphate groups into inositol. Inositol is the cyclic alcohol 1,2,3,4,5,6-cyclohexanehexol, which is widely distributed in nature and acts as a growth factor in animals and microorganisms.','2013-10-27','NSRP'),(35952,52747,'sinapyl alcohol dehydrogenase activity','F','Catalysis of the reaction: sinapaldehyde + NADPH + H+ = sinapyl-alcohol + NADP+.','2013-10-27','NSRP'),(35953,52748,'baicalin beta-D-glucuronidase activity','F','Catalysis of the reaction: baicalin + H2O = baicalein + D-glucuronate.','2013-10-27','NSRP'),(35954,52749,'glucose-6-phosphate dehydrogenase (coenzyme F420) activity','F','Catalysis of the reaction: beta-D-glucose 6-phosphate + coenzyme F420 + H+ = 6-O-phosphono-D-glucono-1,5-lactone + reduced coenzyme F420.','2013-10-27','NSRP'),(35955,52750,'reactive-black-5:hydrogen-peroxide oxidoreductase activity','F','Catalysis of the reaction: reactive black 5 + hydrogen peroxide = oxidized reactive black 5 + 2 H2O.','2013-10-27','NSRP'),(35956,52751,'GDP-mannose hydrolase activity','F','Catalysis of the reaction: GDP-mannose + H2O = GMP + mannose-1-phosphate.','2013-10-27','NSRP'),(35957,52752,'reduced coenzyme F420:heterodisulfide oxidoreductase activity','F','Catalysis of the reaction: reduced coenzyme F420 + CoB-S-S-CoM = coenzyme F420 + CoM-SH + CoB-SH.','2013-10-27','NSRP'),(35958,52753,'propan-2-ol:coenzyme F420 oxidoreductase activity','F','Catalysis of the reaction: propan-2-ol + coenzyme F420 = acetone + reduced coenzyme F420.','2013-10-27','NSRP'),(35959,52754,'GTP:coenzyme F420 guanyltransferase activity','F','Catalysis of the reaction: GTP + factor gamma-F420-2 + H+ = coenzyme F390-G + diphosphate.','2013-10-27','NSRP'),(35960,52755,'reduced coenzyme F420:quinone oxidoreductase activity','F','Catalysis of the reaction: reduced coenzyme F420 + 2,3-dimethyl-1,4-naphthoquinone = coenzyme F420 + reduced 2,3-dimethyl-1,4-naphthoquinone. Reduced 2,3-dimethyl-1,4-naphthoquinone is also known as 2,3-dimethyl-1,4-hydronaphthoquinone.','2013-10-27','NSRP'),(35961,52756,'chitobiose phosphorylase activity','F','Catalysis of the reaction: chitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate. This reaction is the phosphorolysis of chitobiose, (GlcNAc)2, a dimer of beta-(1->4) linked glucosamine units.','2013-10-27','NSRP'),(35962,52757,'chondroitin hydrolase activity','F','Catalysis of the hydrolysis of hexosaminic linkages in chondroitin, a linear polymer structure composed of the repeating disaccharide unit [->4)-D-glucuronic acid-(1->3)-N-acetyl-D-galactosamine-(1-], also written as [->4GlcUA1->3GalNAc1-].','2013-10-27','NSRP'),(35963,52758,'coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity','F','Catalysis of the reaction: 2,4,6-trinitrophenol + H- = 2,4,6-trinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction.','2013-10-27','NSRP'),(35964,52759,'coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity','F','Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex + H- = trinitrophenol dihydride Meisenheimer complex (aci form). Coenzyme F420 supplies the hydride (H-) in the reaction.','2013-10-27','NSRP'),(35965,52760,'coenzyme F420-dependent 2,4-dinitrophenol reductase activity','F','Catalysis of the reaction: 2,4-dinitrophenol + H- = 2,4-dinitrophenol hydride Meisenheimer complex. Coenzyme F420 supplies the hydride (H-) in the reaction.','2013-10-27','NSRP'),(35966,52761,'exo-1,4-beta-D-glucosaminidase activity','F','Catalysis of the reaction: [beta-(1->4)-D-glucosamine]n-[N-acetyl-D-glucosamine]m = D-glucosamine + [beta-(1->4)-D-glucosamine](n-1)-[N-acetyl-D-glucosamine]m. This reaction is the hydrolysis of chitosan or chitosan oligosaccharides to remove a D-glucosamine residue from the non-reducing termini; chitosan is a linear polysaccharide composed of randomly distributed beta-(1->4)-linked D-glucosamine and N-acetyl-D-glucosamine units.','2013-10-27','NSRP'),(35967,52762,'gellan lyase activity','F','Catalysis of the reaction: gellan = n beta-D-4-deoxy-delta4,5-GlcAp-(1->4)-beta-D-Glcp-(1->4)-alpha-L-Rhap-(1->3)-beta-D-Glcp. This reaction is the eliminative cleavage of beta-D-glucopyranosyl-(1->4)-beta-D-glucopyranosyluronate bonds of gellan backbone, releasing tetrasaccharides containing a 4-deoxy-4,5-unsaturated D-glucopyranosyluronic acid at the non-reducing end; in the product, the abbreviations are D-glucose (Glc), D-glucuronic acid (GlcA), and L-rhamnose (Rha).','2013-10-27','NSRP'),(35968,52763,'ulvan lyase activity','F','Catalysis of the cleavage of a carbon-oxygen bond in ulvan, a carbohydrate composed of a repeating structure of [->4)-beta-D-GlcA-(1,4)-alpha-L-Rha 3S-(1->4)-alpha-L-IdoA-(1->4)-alpha-L-Rha 3S-(1-]n. Continued digest of ulvan with an enzyme that can catalyze this reaction results in ulvanobiouronic acid A 3-sulfate [->4)-beta-D-GlcpA-(1->4)-alpha-L-Rhap 3-sulfate-(1-]n with 4-deoxy-L-threo-hex-4-enopyranosiduronic acid at the non-reducing end.','2013-10-27','NSRP'),(35969,52764,'exo-oligoalginate lyase activity','F','Catalysis of the cleavage of glycosidic bonds through a beta-elimination reaction on alginate, a linear polysaccharide consisting of guluronate (G) and mannuronate (M) as the monomer constituents. An oligoalginate is a linear polymer of two, three or four units of (1->4)-alpha-L-guluronic acid and beta-D-mannuronic acid, releasing monosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends.','2013-10-27','NSRP'),(35970,52765,'reduced coenzyme F420 oxidase activity','F','Catalysis of the reaction: 2 reduced coenzyme F420 + O2 = 2 coenzyme F420 + 2 H2O.','2013-10-27','NSRP'),(35971,52766,'mannoside alpha-1,4-mannosidase activity','F','Catalysis of the hydrolysis of the alpha-(1->4) linkage of the terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.','2013-10-27','NSRP'),(35972,52767,'mannosyl-oligosaccharide 1,6-alpha-mannosidase activity','F','Catalysis of the hydrolysis of the alpha-(1->6) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide.','2013-10-27','NSRP'),(35973,52768,'mannosyl-oligosaccharide 1,3-alpha-mannosidase activity','F','Catalysis of the hydrolysis of the alpha-(1->3) bonds of alpha-D-mannose residues in mannosyl-oligosaccharide.','2013-10-27','NSRP'),(35974,52769,'beta-6-sulfate-N-acetylglucosaminidase activity','F','Catalysis of the glycosidic cleavage of the terminal 2-acetamido-2-deoxy-beta-D-glucopyranoside 6-sulfate (6-SO3-GlcNAc) residue from sulfomucin, a sulfated mucin derivative.','2013-10-27','NSRP'),(35975,52770,'coenzyme F390-A hydrolase activity','F','Catalysis of the reaction: coenzyme F390-A = AMP + coenzyme F420.','2013-10-27','NSRP'),(35976,52771,'coenzyme F390-G hydrolase activity','F','Catalysis of the reaction: coenzyme F390-G = GMP + coenzyme F420.','2013-10-27','NSRP'),(35977,52772,'brefeldin A esterase activity','F','Catalysis of the hydrolysis of brefeldin A to produce brefeldin A acid. Brefeldin A is also known as gamma,4-dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid lambda-lactone.','2013-10-27','NSRP'),(35978,52773,'diacetylchitobiose deacetylase activity','F','Catalysis of the reaction: N,N\'-diacetylchitobiose (GlcNac2) + H2O = acetate + 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose (GlcN-GlcNAc).','2013-10-27','NSRP'),(35979,52774,'glucosyl-N-acetylglucosamine glucosaminidase activity','F','Catalysis of the reaction: glucosyl-N-acetylglucosamine + H2O = glucosamine + N-acetylglucosamine.','2013-10-27','NSRP'),(35980,52775,'endo-1,3-alpha-L-rhamnosidase activity','F','Catalysis of the reaction: R1-L-rhamnose-(1->3)-alpha-L-rhamnose-R2 + H2O = R1-L-rhamnose + L-rhamnose-R2. This reaction is the hydrolysis of an alpha-(1->3) linkage between two rhamnose residues in a polysaccharide chain.','2013-10-27','NSRP'),(35981,52776,'diacetylchitobiose catabolic process to glucosamine and acetate','P','The pathway resulting in the breakdown of diacetylchitobiose into simpler products, including glucosamine and glucosamine. The catabolism proceeds by the deacetylation of diacetylchitobiose, producing acetate and GlcN-GlcNAc; the latter is cleaved to produce glucosamine (GlcN) and N-acetylglucosamine (GlcNAc). The N-acetylglucosamine (GlcNAc) is then deacetylated to produce glucosamine (GlcN) and acetate.','2013-10-27','NSRP'),(35982,52777,'diacetylchitobiose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of diacetylchitobiose into simpler products.','2013-10-27','NSRP'),(35983,52778,'diacetylchitobiose metabolic process','P','The chemical reactions and pathways involving diacetylchitobiose, the N,N\'-diacetylated derivative of chitobiose.','2013-10-27','NSRP'),(35984,52779,'amino disaccharide metabolic process','P','The chemical reactions and pathways involving any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.','2013-10-27','NSRP'),(35985,52780,'chitobiose metabolic process','P','The chemical reactions and pathways involving chitobioses, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine.','2013-10-27','NSRP'),(35986,52781,'chitobiose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any chitobiose, a family of compounds derived from chitin and based on the structure of D-glucosaminyl-(1->4)-D-glucosamine.','2013-10-27','NSRP'),(35987,52782,'amino disaccharide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any amino disaccharide, a disaccharide having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.','2013-10-27','NSRP'),(35988,52783,'reuteran metabolic process','P','The chemical reactions and pathways involving reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages.','2013-10-27','NSRP'),(35989,52784,'reuteran biosynthetic process','P','The chemical reactions and pathways resulting in the formation of reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages.','2013-10-27','NSRP'),(35990,52785,'cellulose catabolism by endo-processive cellulases','P','The breakdown into simpler components of cellulose. Catabolism is initiated by endohydrolytic attacks on the cellulose chain, and the resulting pieces are further degraded by cellulase enzymes to produce smaller and smaller fragments.','2013-10-27','NSRP'),(35991,52786,'alpha-linked polysaccharide catabolism to maltotriose','P','The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltotriose.','2013-10-27','NSRP'),(35992,52787,'alpha-linked polysaccharide catabolism to maltopentaose','P','The breakdown of large alpha-linked polysaccharides by hydrolysis of (1->4)-alpha-D-glucosidic linkages to yield maltopentaose.','2013-10-27','NSRP'),(35993,52788,'d-4,5 unsaturated beta-glucuronyl hydrolase activity','F','Catalysis of the hydrolysis of the glycosidic bond in an unsaturated saccharide between the unsaturated glucuronyl residue at the nonreducing terminus and the saccharide linked to the residue.','2013-10-27','NSRP'),(35994,52789,'mannan 1,3-beta-mannosidase activity','F','Catalysis of the hydrolysis of (1->3)-beta-D-mannosidic linkages in mannans, releasing mannose.','2013-10-27','NSRP'),(35995,52790,'chitooligosaccharide deacetylase activity','F','Catalysis of the reaction: chitooligosaccharide with N-acetylglucosamine at nonreducing terminal + H2O = chitooligosaccharide with glucosamine at nonreducing terminal + acetate. This reaction is the deacetylation of a chitooligosaccharide at the nonreducing N-acetylglucosamine residue; chitooligosaccharide are composed of (1->4)-linked D-glucosamine (GlcN) and N-acetyl-D-glucosamine (GlcNAc) in varying proportions.','2013-10-27','NSRP'),(35996,52791,'3-deoxy-D-glycero-D-galacto-2-nonulosonic acid hydrolase activity','F','Catalysis of the reaction: (2-keto-3-deoxynononic acid)n + H2O = (2-keto-3-deoxynononic acid)n-1 + 2-keto-3-deoxynononic acid. This reaction is the hydrolysis of a 2-keto-3-deoxynononic acid residue from a poly-2-keto-3-deoxynononic acid chain.','2013-10-27','NSRP'),(35997,52792,'endo-xylogalacturonan hydrolase activity','F','Catalysis of the endohydrolysis of xylogalacturonate by cleavage of the alpha-(1,4)-linkage. Xylogalacturonate (XGA) is composed of a chain of alpha-(1,4)-linked D-galacturonic acid residues with beta-D-xylose substituted at the O3 position.','2013-10-27','NSRP'),(35998,52793,'pectin acetylesterase activity','F','Catalysis of the reaction: pectin + H2O = pectate + acetate. This reaction is the hydrolysis of acetyl esters of pectin, producing pectate, partially esterified pectin.','2013-10-27','NSRP'),(35999,52794,'exo-alpha-(2->3)-sialidase activity','F','Catalysis of the hydrolysis of alpha-(2->3)-glycosidic linkages of terminal sialic residues in substrates.','2013-10-27','NSRP'),(36000,52795,'exo-alpha-(2->6)-sialidase activity','F','Catalysis of the hydrolysis of alpha-(2->6)-glycosidic linkages of terminal sialic residues in substrates.','2013-10-27','NSRP'),(36001,52796,'exo-alpha-(2->8)-sialidase activity','F','Catalysis of the hydrolysis of alpha-(2->8)-glycosidic linkages of terminal sialic residues in substrates.','2013-10-27','NSRP'),(36002,52797,'4-O-methyl-glucuronoyl methylesterase activity','F','Catalysis of the reaction: [X]-4-O-methyl-D-glucuronic acid + H2O = [X]-OH + methyl-D-glucuronic acid. This reaction is the hydrolysis of the ester linkage between 4-O-methyl-D-glucuronic acid (MeGlcA) and an alcohol (-OH) group attached to a molecule, denoted here as [X].','2013-10-27','NSRP'),(36003,52798,'beta-galactoside alpha-2,3-sialyltransferase activity','F','Catalysis of the transfer of sialyl residues alpha-2,3-linked to a beta galactosyl residue on the donor to form an alpha-2,3 linkage to a terminal beta galactosyl residue on the acceptor.','2013-10-27','NSRP'),(36004,52799,'coenzyme F420-dependent bicyclic nitroimidazole catabolic process','P','The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates.','2013-10-27','NSRP'),(36005,52800,'bicyclic nitroimidazole catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a bicyclic nitroimidazole.','2013-10-27','NSRP'),(36006,52801,'bicyclic nitroimidazole metabolic process','P','The chemical reactions and pathways involving bicyclic nitroimidazoles, imidazole derivatives with two rings and a nitro group attached to one ring.','2013-10-27','NSRP'),(36007,52802,'nitroimidazole metabolic process','P','The chemical reactions and pathways involving nitroimidazoles, imidazole derivatives with a nitro group attached to one ring.','2013-10-27','NSRP'),(36008,52803,'imidazole-containing compound metabolic process','P','The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.','2013-10-27','NSRP'),(36009,52804,'nitroimidazole catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nitroimidazoles, imidazole derivatives with a nitro group attached to one ring.','2013-10-27','NSRP'),(36010,52805,'imidazole-containing compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton.','2013-10-27','NSRP'),(36011,52806,'sulfite reductase (coenzyme F420) activity','F','Catalysis of the reaction: sulfite + 3 1,5-dihydrocoenzyme F420 = hydrogen sulfide + 3 H2O + 3 coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420.','2013-10-27','NSRP'),(36012,52807,'aflatoxin reductase (coenzyme F420) activity','F','Catalysis of the reaction: aflatoxin + 1,5-dihydrocoenzyme F420 = aflatoxin with reduced furanocoumarin moiety + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420.','2013-10-27','NSRP'),(36013,52808,'reduced coenzyme F420:NADP+ oxidoreductase activity','F','Catalysis of the reaction: NADP+ + 1,5-dihydrocoenzyme F420 = NADPH + H+ + coenzyme F420. 1,5-dihydrocoenzyme F420 is also known as reduced coenzyme F420.','2013-10-27','NSRP'),(36014,52809,'acharan sulfate lyase activity','F','Catalysis of the cleavage of a carbon-oxygen bond in acharan sulfate, a glycosaminoglycan with a uniformly repeating disaccharide structure of alpha-D-N-acetylglucosaminyl-2-O-sulfo-alpha-L-iduronic acid.','2013-10-27','NSRP'),(36015,52810,'1-phosphatidylinositol-5-kinase activity','F','Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 5-phosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(36016,52811,'1-phosphatidylinositol-3-phosphate 4-kinase activity','F','Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(36017,52812,'phosphatidylinositol-3,4-bisphosphate 5-kinase activity','F','Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(36018,52813,'phosphatidylinositol bisphosphate kinase activity','F','Catalysis of the reaction: ATP + a phosphatidylinositol bisphosphate = ADP + a phosphatidylinositol trisphosphate.','2013-10-27','NSRP'),(36019,52814,'medium-chain-aldehyde dehydrogenase activity','F','Catalysis of the reaction: a medium-chain aldehyde + NAD+ = a medium-chain carboxylate + NADH + H+. Medium-chain aldehydes have a chain length of between 8 and 12 carbons.','2013-10-27','NSRP'),(36020,52815,'medium-chain acyl-CoA hydrolase activity','F','Catalysis of the reaction: H2O + a medium-chain acyl-CoA = a medium-chain carboxylate + CoA. A medium chain is a chain of between eight and twelve carbons in length.','2013-10-27','NSRP'),(36021,52816,'long-chain acyl-CoA hydrolase activity','F','Catalysis of the reaction: H2O + a long-chain acyl-CoA = a long-chain carboxylate + CoA. A long chain is a chain of greater than 12 carbons in length.','2013-10-27','NSRP'),(36022,52817,'very long chain acyl-CoA hydrolase activity','F','Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18.','2013-10-27','NSRP'),(36023,52818,'heteroglycan 3-alpha-mannosyltransferase activity','F','Catalysis of the reaction: heteroglycan + GDP-mannose = (1->3)-alpha-D-mannosylheteroglycan + GDP.','2013-10-27','NSRP'),(36024,52819,'heteroglycan 2-alpha-mannosyltransferase activity','F','Catalysis of the reaction: heteroglycan + GDP-mannose = (1->2)-alpha-D-mannosylheteroglycan + GDP.','2013-10-27','NSRP'),(36025,52820,'DNA-1,N6-ethenoadenine N-glycosylase activity','F','Catalysis of the reaction: DNA with 1-N6-ethenoadenine + H2O = DNA with abasic site + 1-N6-ethenoadenine. This reaction is the removal of 1,N6-ethenoadenine by cleaving the N-C1\' glycosidic bond between the target damaged DNA base and the deoxyribose sugar.','2013-10-27','NSRP'),(36026,52821,'DNA-7-methyladenine glycosylase activity','F','Catalysis of the reaction: DNA containing 7-methyladenine + H2O = DNA with abasic site + 7-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1\' glycosidic bond between the damaged DNA 7-methyladenine and the deoxyribose sugar to remove the 7-methyladenine, leaving an abasic site.','2013-10-27','NSRP'),(36027,52822,'DNA-3-methylguanine glycosylase activity','F','Catalysis of the reaction: DNA containing 3-methylguanine + H2O = DNA with abasic site + 3-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1\' glycosidic bond between the damaged DNA 3-methylguanine and the deoxyribose sugar to remove the 3-methylguanine, leaving an abasic site.','2013-10-27','NSRP'),(36028,52823,'2-hydroxy-6-oxonona-2,4,7-trienedioate hydrolase activity','F','Catalysis of the reaction: (2E,4Z,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + fumarate + H+.','2013-10-27','NSRP'),(36029,52824,'dolichyl-pyrophosphate Man7GlcNAc2 alpha-1,6-mannosyltransferase activity','F','Catalysis of the addition of mannose to dolichyl-pyrophosphate Man7GlcNAc2 (also written as Man7GlcNAc2-PP-Dol) in alpha-(1->6) linkage, producing Man8GlcNAc2-PP-Dol.','2013-10-27','NSRP'),(36030,52825,'inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity','F','Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-3,4,5,6-tetrakisphosphate + phosphate.','2013-10-27','NSRP'),(36031,52826,'inositol hexakisphosphate 2-phosphatase activity','F','Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol 1,3,4,5,6-pentakisphosphate + phosphate.','2013-10-27','NSRP'),(36032,52827,'inositol pentakisphosphate phosphatase activity','F','Catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate.','2013-10-27','NSRP'),(36033,52828,'inositol-3,4-bisphosphate 4-phosphatase activity','F','Catalysis of the reaction: 1D-myo-inositol 3,4-bisphosphate + H2O = 1D-myo-inositol 3-phosphate + phosphate.','2013-10-27','NSRP'),(36034,52829,'inositol-1,3,4-trisphosphate 1-phosphatase activity','F','Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate.','2013-10-27','NSRP'),(36035,52830,'inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity','F','Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate.','2013-10-27','NSRP'),(36036,52831,'inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity','F','Catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-3,4,6-trisphosphate + phosphate.','2013-10-27','NSRP'),(36037,52832,'inositol monophosphate 3-phosphatase activity','F','Catalysis of the reaction: myo-inositol 3-phosphate + H2O = myo-inositol + phosphate.','2013-10-27','NSRP'),(36038,52833,'inositol monophosphate 4-phosphatase activity','F','Catalysis of the reaction: myo-inositol 4-phosphate + H2O = myo-inositol + phosphate.','2013-10-27','NSRP'),(36039,52834,'inositol monophosphate phosphatase activity','F','Catalysis of the reaction: myo-inositol phosphate + H2O = myo-inositol + phosphate.','2013-10-27','NSRP'),(36040,52835,'inositol-3,4,6-trisphosphate 1-kinase activity','F','Catalysis of the reaction: 1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(36041,52836,'inositol 5-diphosphate pentakisphosphate 5-kinase activity','F','Catalysis of the reaction: ATP + inositol 5-diphosphate pentakisphosphate = ADP + inositol 5-triphosphate pentakisphosphate.','2013-10-27','NSRP'),(36042,52837,'thiazole biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position.','2013-10-27','NSRP'),(36043,52838,'thiazole metabolic process','P','The chemical reactions and pathways involving oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position.','2013-10-27','NSRP'),(36044,52839,'inositol diphosphate tetrakisphosphate kinase activity','F','Catalysis of the reaction: Catalysis of the reaction: ATP + inositol diphosphate tetrakisphosphate = ADP + inositol bisdiphosphate trisphosphate.','2013-10-27','NSRP'),(36045,52840,'inositol diphosphate tetrakisphosphate diphosphatase activity','F','Catalysis of the reaction: inositol diphosphate tetrakisphosphate + H2O = inositol 1,3,4,5,6-pentakisphosphate + phosphate.','2013-10-27','NSRP'),(36046,52841,'inositol bisdiphosphate tetrakisphosphate diphosphatase activity','F','Catalysis of the reaction: inositol bisdiphosphate tetrakisphosphate + H2O = inositol diphosphate pentakisphosphate + phosphate.','2013-10-27','NSRP'),(36047,52842,'inositol diphosphate pentakisphosphate diphosphatase activity','F','Catalysis of the reaction: inositol diphosphate pentakisphosphate + H2O = inositol hexakisphosphate + phosphate.','2013-10-27','NSRP'),(36048,52843,'inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity','F','Catalysis of the reaction: inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.','2013-10-27','NSRP'),(36049,52844,'inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity','F','Catalysis of the reaction: inositol 3-diphosphate 1,2,4,5,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.','2013-10-27','NSRP'),(36050,52845,'inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity','F','Catalysis of the reaction: inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate + H2O = inositol 1,2,3,4,5,6-hexakisphosphate + phosphate + 2 H+.','2013-10-27','NSRP'),(36051,52846,'inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity','F','Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + phosphate + H+.','2013-10-27','NSRP'),(36052,52847,'inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity','F','Catalysis of the reaction: 1,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + H+.','2013-10-27','NSRP'),(36053,52848,'inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity','F','Catalysis of the reaction: 3,5-bisdiphosphoinositol-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + H+.','2013-10-27','NSRP'),(36054,52849,'NADPH-dependent curcumin reductase activity','F','Catalysis of the reaction: curcumin + NADPH + H+ = dihydrocurcumin + NADP+.','2013-10-27','NSRP'),(36055,52850,'NADPH-dependent dihydrocurcumin reductase activity','F','Catalysis of the reaction: dihydrocurcumin + NADPH+ + H+ = tetrahydrocurcumin + NADP+.','2013-10-27','NSRP'),(36056,52851,'ferric-chelate reductase (NADPH) activity','F','Catalysis of the reaction: 2 Fe3+ + NADPH = 2 Fe2+ + H+ + NADP+ .','2013-10-27','NSRP'),(36057,52852,'very-long-chain-(S)-2-hydroxy-acid oxidase activity','F','Catalysis of the reaction: very-long-chain (S)-2-hydroxy-acid + O2 = very-long-chain 2-oxo acid + hydrogen peroxide. Very long chain refers to a chain length of greater than 18 carbons.','2013-10-27','NSRP'),(36058,52853,'long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity','F','Catalysis of the reaction: long-chain-(S)-2-hydroxy-acid + O2 = long-chain-2-oxo acid + hydrogen peroxide. Long chain refers to a chain length of 14 to 18 carbons.','2013-10-27','NSRP'),(36059,52854,'medium-chain-(S)-2-hydroxy-acid oxidase activity','F','Catalysis of the reaction: medium-chain-(S)-2-hydroxy-acid + O2 = medium-chain-2-oxo acid + hydrogen peroxide. Medium chain refers to a chain length of between 8 and 12 carbons.','2013-10-27','NSRP'),(36060,52855,'ADP-dependent NAD(P)H-hydrate dehydratase activity','F','Catalysis of the reaction: (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide adenine dinucleotide + ADP = AMP + 3 H(+) + NADH + phosphate.','2013-10-27','NSRP'),(36061,52856,'NADHX epimerase activity','F','Catalysis of the reaction: (R)-NADHX = (S)-NADHX.','2013-10-27','NSRP'),(36062,52857,'NADPHX epimerase activity','F','Catalysis of the reaction: (R)-NADPHX = (S)-NADPHX.','2013-10-27','NSRP'),(36063,52858,'peptidyl-lysine N-acetyltransferase activity','F','Catalysis of the reaction: acetyl phosphate + peptidyl-L-lysine = phosphate + peptidyl-N6-acetyl-L-lysine.','2013-10-27','NSRP'),(36064,52859,'glucan endo-1,4-beta-glucosidase activity','F','Catalysis of the random hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans.','2013-10-27','NSRP'),(36065,52860,'2\'-deoxymugineic-acid 3-dioxygenase activity','F','Catalysis of the reaction: 2\'-deoxymugineic acid + 2-oxoglutarate + O2 = 3-epihydroxy-2\'-deoxymugineic acid + succinate + CO2.','2013-10-27','NSRP'),(36066,52861,'glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group','F','Catalysis of the endohydrolysis of (1->3)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3.','2013-10-27','NSRP'),(36067,52862,'glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group','F','Catalysis of the endohydrolysis of (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolysed is itself substituted at C-3.','2013-10-27','NSRP'),(36068,52863,'1-deoxy-D-xylulose 5-phosphate metabolic process','P','The chemical reactions and pathways involving 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.','2013-10-27','NSRP'),(36069,52864,'1-deoxy-D-xylulose 5-phosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.','2013-10-27','NSRP'),(36070,52865,'1-deoxy-D-xylulose 5-phosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.','2013-10-27','NSRP'),(36071,52866,'phosphatidylinositol phosphate phosphatase activity','F','Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate.','2013-10-27','NSRP'),(36072,52867,'phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity','F','Catalysis of the reaction: phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate + phosphate.','2013-10-27','NSRP'),(36073,52868,'protein-lysine lysyltransferase activity','F','Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine.','2013-10-27','NSRP'),(36074,52869,'arachidonic acid omega-hydroxylase activity','F','Catalysis of the reaction: arachidonic acid + O2 + NADPH + H+ = 20-HETE + NADP+ + H2O. Arachidonic acid is also known as (5Z,8Z,11Z,14Z)-icosatetraenoic acid, and 20-HETE is also known as (5Z,8Z,11Z,14Z)-20-hydroxyicosa-5,8,11,14-tetraenoic acid.','2013-10-27','NSRP'),(36075,52870,'tocopherol omega-hydroxylase activity','F','Catalysis of the reaction: tocopherol + O2 + NADPH + H+ = 13\'-hydroxy-tocopherol + NADP+ + H2O .','2013-10-27','NSRP'),(36076,52871,'alpha-tocopherol omega-hydroxylase activity','F','Catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13\'-hydroxy-alpha-tocopherol + NADP+ + H2O .','2013-10-27','NSRP'),(36077,52872,'tocotrienol omega-hydroxylase activity','F','Catalysis of the reaction: tocotrienol + O2 + NADPH + H+ = 13\'-hydroxy-tocotrienol + NADP+ + H2O .','2013-10-27','NSRP'),(36078,52873,'FMN reductase (NADPH) activity','F','Catalysis of the reaction: FMNH2 + NADP+ = FMN + NADPH + 2 H+.','2013-10-27','NSRP'),(36079,52874,'FMN reductase (NADH) activity','F','Catalysis of the reaction: FMNH2 + NAD+ = FMN + NADH + 2 H+.','2013-10-27','NSRP'),(36080,52875,'riboflavin reductase (NADH) activity','F','Catalysis of the reaction: reduced riboflavin + NAD+ = riboflavin + NADH + 2 H+.','2013-10-27','NSRP'),(36081,52876,'methylamine dehydrogenase (amicyanin) activity','F','Catalysis of the reaction: methylamine + H2O + amicyanin = formaldehyde + ammonia + reduced amicyanin.','2013-10-27','NSRP'),(36082,52877,'oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor','F','Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and a copper protein is the acceptor.','2013-10-27','NSRP'),(36083,52878,'linoleate 8R-lipoxygenase activity','F','Catalysis of the reaction: O(2) + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate.','2013-10-27','NSRP'),(36084,52879,'9,12-octadecadienoate 8-hydroperoxide 8S-isomerase activity','F','Catalysis of the reaction: (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate = (7S,8S,9Z,12Z)-7,8-dihydroxyoctadeca-9,12-dienoate.','2013-10-27','NSRP'),(36085,52880,'oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor','F','Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a copper protein.','2013-10-27','NSRP'),(36086,52881,'4-hydroxyphenylacetate 3-monooxygenase activity','F','Catalysis of the reaction: (4-hydroxyphenyl)acetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(+) + H(2)O.','2013-10-27','NSRP'),(36087,52882,'oxidoreductase activity, acting on phosphorus or arsenic in donors, with a copper protein as acceptor','F','Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a copper protein.','2013-10-27','NSRP'),(36088,52883,'tyrosine ammonia-lyase activity','F','Catalysis of the reaction: L-tyrosine = NH(4)(+) + trans-4-coumarate.','2013-10-27','NSRP'),(36089,52884,'all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity','F','Catalysis of the reaction: H(2)O + all-trans-retinyl palmitate = 11-cis-retinol + H(+) + palmitate.','2013-10-27','NSRP'),(36090,52885,'all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity','F','Catalysis of the reaction: H(2)O + all-trans-retinyl ester = 11-cis-retinol + fatty acid.','2013-10-27','NSRP'),(36091,52886,'9,9\'-dicis-carotene:quinone oxidoreductase activity','F','Catalysis of the reaction: 9,9\'-di-cis-zeta-carotene + a quinone = 7,9,9\'-tri-cis-neurosporene + a quinol.','2013-10-27','NSRP'),(36092,52887,'7,9,9\'-tricis-neurosporene:quinone oxidoreductase activity','F','Catalysis of the reaction: 7,9,9\'-tri-cis-neurosporene + a quinone = 7,9,7\',9\'-tetra-cis-lycopene + a quinol.','2013-10-27','NSRP'),(36093,52888,'dihydroorotate oxidase (fumarate) activity','F','Catalysis of the reaction: (S)-dihydroorotate + fumarate = orotate + succinate.','2013-10-27','NSRP'),(36094,52889,'9,9\'-di-cis-zeta-carotene desaturation to 7,9,7\',9\'-tetra-cis-lycopene','P','The series of reactions in which 9,9\'-di-cis-zeta-carotene is desaturated to 7,9,9\'-tri-cis-neurosporene, and then 7,9,7\',9\'-tetra-cis-lycopene. The overall reaction for this process is: 9,9\'-di-cis-zeta-carotene + 2 quinone = 2 quinol + 7,9,7\',9\'-tetra-cis-lycopene.','2013-10-27','NSRP'),(36095,52890,'oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor','F','Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin.','2013-10-27','NSRP'),(36096,52891,'aliphatic (S)-hydroxynitrile lyase activity','F','Catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide.','2013-10-27','NSRP'),(36097,52892,'aromatic (S)-hydroxynitrile lyase activity','F','Catalysis of the reaction: an aromatic (S)-hydroxynitrile = an aromatic aldehyde + cyanide.','2013-10-27','NSRP'),(36098,52893,'N1-acetylspermine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity','F','Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N-(3-acetamidopropyl)-4-aminobutanal + propane-1,3-diamine + hydrogen peroxide.','2013-10-27','NSRP'),(36099,52894,'norspermine:oxygen oxidoreductase activity','F','Catalysis of the reaction: norspermine + oxygen + H2O = norspermidine + 3-aminopropanal + hydrogen peroxide.','2013-10-27','NSRP'),(36100,52895,'N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity','F','Catalysis of the reaction: N1-acetylspermine + oxygen + H2O = N1-acetylspermidine + 3-aminopropanal + hydrogen peroxide.','2013-10-27','NSRP'),(36101,52896,'spermidine oxidase (propane-1,3-diamine-forming) activity','F','Catalysis of the reaction: H(2)O + O(2) + spermidine = 1,3-diaminopropane + 4-aminobutanal + H(2)O(2).','2013-10-27','NSRP'),(36102,52897,'N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity','F','Catalysis of the reaction: H(2)O + N(8)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2).','2013-10-27','NSRP'),(36103,52898,'N1-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity','F','Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 1,3-diaminopropane + 4-acetamidobutanal + H(2)O(2).','2013-10-27','NSRP'),(36104,52899,'N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity','F','Catalysis of the reaction: H(2)O + N(1),N(12)-diacetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + N(1)-acetylspermidine.','2013-10-27','NSRP'),(36105,52900,'spermine oxidase (propane-1,3-diamine-forming) activity','F','Catalysis of the reaction: H(2)O + O(2) + spermine = 1,3-diaminopropane + H(2)O(2) + N-(3-aminopropyl)-4-aminobutanal.','2013-10-27','NSRP'),(36106,52901,'spermine:oxygen oxidoreductase (spermidine-forming) activity','F','Catalysis of the reaction: H(2)O + O(2) + spermine = 3-aminopropanal + H(2)O(2) + spermidine.','2013-10-27','NSRP'),(36107,52902,'spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity','F','Catalysis of the reaction: H(2)O + O(2) + spermidine = 3-aminopropanal + H(2)O(2) + putrescine.','2013-10-27','NSRP'),(36108,52903,'N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity','F','Catalysis of the reaction: H(2)O + N(1)-acetylspermine + O(2) = 3-acetamidopropanal + H(2)O(2) + spermidine.','2013-10-27','NSRP'),(36109,52904,'N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity','F','Catalysis of the reaction: H(2)O + N(1)-acetylspermidine + O(2) = 3-acetamidopropanal + H(2)O(2) + putrescine.','2013-10-27','NSRP'),(36110,52905,'tRNA (guanine(9)-N(1))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(36111,52906,'tRNA (guanine(37)-N(1))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanine(37) in tRNA = N(1)-methylguanine(37) in tRNA + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(36112,52907,'23S rRNA (adenine(1618)-N(6))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA.','2013-10-27','NSRP'),(36113,52908,'16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity','F','Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.','2013-10-27','NSRP'),(36114,52909,'18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity','F','Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.','2013-10-27','NSRP'),(36115,52910,'23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity','F','Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA.','2013-10-27','NSRP'),(36116,52911,'23S rRNA (guanine(745)-N(1))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanine(745) in 23S rRNA = N(1)-methylguanine(745) in 23S rRNA + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(36117,52912,'23S rRNA (guanine(748)-N(1))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanine(748) in 23S rRNA = N(1)-methylguanine(748) in 23S rRNA + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(36118,52913,'16S rRNA (guanine(966)-N(2))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(966) in 16S rRNA = N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(36119,52914,'16S rRNA (guanine(1207)-N(2))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = N(2)-methylguanosine(1207) in 16S rRNA + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(36120,52915,'23S rRNA (guanine(2445)-N(2))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(36121,52916,'23S rRNA (guanine(1835)-N(2))-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1835) in 23S rRNA = N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(36122,52917,'dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity','F','Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.','2013-10-27','NSRP'),(36123,52918,'dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity','F','Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.','2013-10-27','NSRP'),(36124,52919,'aliphatic (R)-hydroxynitrile lyase activity','F','Catalysis of the reaction: an aliphatic (R)-hydroxynitrile = an aliphatic aldehyde or ketone + hydrogen cyanide.','2013-10-27','NSRP'),(36125,52920,'(2R)-2-hydroxy-2-methylbutanenitrile lyase activity','F','Catalysis of the reaction: (2R)-2-hydroxy-2-methylbutanenitrile = butan-2-one + hydrogen cyanide.','2013-10-27','NSRP'),(36126,52921,'acetone-cyanohydrin acetone-lyase (cyanide-forming) activity','F','Catalysis of the reaction: acetone cyanohydrin = hydrogen cyanide + acetone.','2013-10-27','NSRP'),(36127,52922,'hexaprenyl diphosphate synthase (geranylgeranyl-diphosphate specific) activity','F','Catalysis of the reaction: geranylgeranyl diphosphate + 2 isopentenyl diphosphate = 2 diphosphate + all-trans-hexaprenyl diphosphate.','2013-10-27','NSRP'),(36128,52923,'all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity','F','Catalysis of the reaction: geranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-nonaprenyl diphosphate.','2013-10-27','NSRP'),(36129,52924,'all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity','F','Catalysis of the reaction: geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate.','2013-10-27','NSRP'),(36130,52925,'dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity','F','Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.','2013-10-27','NSRP'),(36131,52926,'dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity','F','Catalysis of the reaction: alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.','2013-10-27','NSRP'),(36132,52927,'CTP:tRNA cytidylyltransferase activity','F','Catalysis of the reaction: a tRNA precursor + CTP = a tRNA with a 3\' cytidine end + diphosphate.','2013-10-27','NSRP'),(36133,52928,'CTP:3\'-cytidine-tRNA cytidylyltransferase activity','F','Catalysis of the reaction: a tRNA with a 3\' cytidine + CTP = a tRNA with a 3\' CC end + diphosphate.','2013-10-27','NSRP'),(36134,52929,'ATP:3\'-cytidine-cytidine-tRNA adenylyltransferase activity','F','Catalysis of the reaction: a tRNA with a 3\' CC end + ATP = a tRNA with a 3\' CCA end + diphosphate.','2013-10-27','NSRP'),(36135,52930,'methanol ferricytochrome-c oxidoreductase activity','F','Catalysis of the reaction: methanol + 2 ferricytochrome c = formaldehyde + 2 ferrocytochrome c + 2 H+.','2013-10-27','NSRP'),(36136,52931,'ethanol cytochrome-c oxidoreductase activity','F','Catalysis of the reaction: ethanol + 2 cytochrome c(L) = acetaldehyde + 2 reduced cytochrome c(L) + 2 H+.','2013-10-27','NSRP'),(36137,52932,'2-chloroethanol cytochrome-c oxidoreductase activity','F','Catalysis of the reaction: 2-chloroethanol + 2 cytochrome c(L) = chloroacetaldehyde + 2 reduced cytochrome c(L).','2013-10-27','NSRP'),(36138,52933,'alcohol dehydrogenase (cytochrome c(L)) activity','F','Catalysis of the reaction: primary alcohol + 2 cytochrome c(L) = 2 reduced cytochrome c(L) + an aldehyde + 2 H+.','2013-10-27','NSRP'),(36139,52934,'alcohol dehydrogenase (cytochrome c) activity','F','Catalysis of the reaction: primary alcohol + 2 cytochrome c = 2 reduced cytochrome c + an aldehyde + 2 H+.','2013-10-27','NSRP'),(36140,52935,'ethanol:cytochrome c oxidoreductase activity','F','Catalysis of the reaction: ethanol + 2 cytochrome c = 2 reduced cytochrome c + acetaldehyde.','2013-10-27','NSRP'),(36141,52936,'2-chloroethanol:cytochrome c oxidoreductase activity','F','Catalysis of the reaction: 2-chloroethanol + 2 cytochrome c = chloroacetaldehyde + 2 reduced cytochrome c.','2013-10-27','NSRP'),(36142,61392,'regulation of transcription from RNA polymerase II promoter in response to osmotic stress','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.','2013-10-27','NSRP'),(36143,61393,'positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.','2013-10-27','NSRP'),(36144,61394,'regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance','P','Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.','2013-10-27','NSRP'),(36145,61395,'positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.','2013-10-27','NSRP'),(36146,61396,'regulation of transcription from RNA polymerase II promoter in response to copper ion','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus.','2013-10-27','NSRP'),(36147,61397,'positive regulation of transcription from RNA polymerase II promoter in response to copper ion','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus.','2013-10-27','NSRP'),(36148,61398,'negative regulation of transcription from RNA polymerase II promoter in response to copper ion','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an copper ion stimulus.','2013-10-27','NSRP'),(36149,61399,'positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus.','2013-10-27','NSRP'),(36150,61400,'positive regulation of transcription from RNA polymerase II promoter in response to calcium ion','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a calcium ion stimulus.','2013-10-27','NSRP'),(36151,61401,'positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.','2013-10-27','NSRP'),(36152,61402,'positive regulation of transcription from RNA polymerase II promoter in response to acidity','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH stimulus with pH < 7.','2013-10-27','NSRP'),(36153,61403,'positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.','2013-10-27','NSRP'),(36154,61404,'positive regulation of transcription from RNA polymerase II promoter in response to increased salt','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.','2013-10-27','NSRP'),(36155,61405,'positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it.','2013-10-27','NSRP'),(36156,61406,'positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of glucose.','2013-10-27','NSRP'),(36157,61407,'positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus.','2013-10-27','NSRP'),(36158,61408,'positive regulation of transcription from RNA polymerase II promoter in response to heat stress','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.','2013-10-27','NSRP'),(36159,61409,'positive regulation of transcription from RNA polymerase II promoter in response to freezing','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a freezing stimulus, temperatures below 0 degrees Celsius.','2013-10-27','NSRP'),(36160,61410,'positive regulation of transcription from RNA polymerase II promoter in response to ethanol','P','Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an ethanol stimulus.','2013-10-27','NSRP'),(36161,61411,'positive regulation of transcription from RNA polymerase II promoter in response to cold','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.','2013-10-27','NSRP'),(36162,61412,'positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of amino acids.','2013-10-27','NSRP'),(36163,61413,'regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source','P','A transcription regulation process in which the presence of a nonfermentable carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.','2013-10-27','NSRP'),(36164,61414,'positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source','P','A transcription regulation process in which the presence of a nonfermentable carbon source leads to an increase of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.','2013-10-27','NSRP'),(36165,61415,'negative regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source','P','A transcription regulation process in which the presence of a nonfermentable carbon source leads to a decrease of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.','2013-10-27','NSRP'),(36166,61416,'regulation of transcription from RNA polymerase II promoter in response to salt stress','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.','2013-10-27','NSRP'),(36167,61417,'negative regulation of transcription from RNA polymerase II promoter in response to oxidative stress','P','Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.','2013-10-27','NSRP'),(36168,61418,'regulation of transcription from RNA polymerase II promoter in response to hypoxia','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.','2013-10-27','NSRP'),(36169,61419,'positive regulation of transcription from RNA polymerase II promoter in response to hypoxia','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.','2013-10-27','NSRP'),(36170,61420,'regulation of transcription from RNA polymerase II promoter in response to biotin starvation','P','Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of biotin.','2013-10-27','NSRP'),(36171,61421,'positive regulation of transcription by oleic acid','P','Any process involving oleic acid that activates or increases the rate of transcription.','2013-10-27','NSRP'),(36172,61422,'positive regulation of transcription from RNA polymerase II promoter in response to alkalinity','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a pH >7.0.','2013-10-27','NSRP'),(36173,61423,'positive regulation of sodium ion transport by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter resulting in the increased frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(36174,61424,'positive regulation of peroxisome organization by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of peroxisome organization.','2013-10-27','NSRP'),(36175,61425,'positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of an ethanol catabolic process.','2013-10-27','NSRP'),(36176,61426,'positive regulation of sulfite transport by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter and activates or increases the frequency, rate or extent of sulfite transport.','2013-10-27','NSRP'),(36177,61427,'negative regulation of ceramide biosynthetic process by negative regulation of transcription from RNA Polymerase II promoter','P','Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter and stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.','2013-10-27','NSRP'),(36178,61428,'negative regulation of transcription from RNA polymerase II promoter in response to hypoxia','P','Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hypoxia stimulus.','2013-10-27','NSRP'),(36179,61429,'positive regulation of transcription from RNA polymerase II promoter by oleic acid','P','Any process involving oleic acid that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(36180,61430,'bone trabecula morphogenesis','P','The process of shaping a trabecula in bone. A trabecula is a tissue element in the form of a small beam, strut or rod.','2013-10-27','NSRP'),(36181,61431,'cellular response to methionine','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methionine stimulus.','2013-10-27','NSRP'),(36182,61432,'regulation of transcription from RNA polymerase II promoter in response to methionine','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a methionine stimulus.','2013-10-27','NSRP'),(36183,61433,'cellular response to caloric restriction','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a of caloric restriction, insufficient food energy intake.','2013-10-27','NSRP'),(36184,61434,'regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction','P','Any process that modulates the frequency, rate or extent of replicative cell aging through a mechanism that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a caloric restriction stimulus.','2013-10-27','NSRP'),(36185,61435,'positive regulation of transcription from a mobile element promoter','P','Any process that activates or increases the frequency, rate or extent of transcription from a mobile element promoter.','2013-10-27','NSRP'),(36186,61436,'establishment of skin barrier','P','Establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.','2013-10-27','NSRP'),(36187,61437,'renal system vasculature development','P','The process whose specific outcome is the progression of vasculature of the renal system over time, from its formation to the mature structure.','2013-10-27','NSRP'),(36188,61438,'renal system vasculature morphogenesis','P','The process in which the renal system vasculature is generated and organized. Morphogenesis pertains to the creation of form.','2013-10-27','NSRP'),(36189,61439,'kidney vasculature morphogenesis','P','The process in which the kidney vasculature is generated and organized. Morphogenesis pertains to the creation of form.','2013-10-27','NSRP'),(36190,61440,'kidney vasculature development','P','The process whose specific outcome is the progression of the vasculature of the kidney over time, from its formation to the mature structure.','2013-10-27','NSRP'),(36191,61441,'renal artery morphogenesis','P','The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood.','2013-10-27','NSRP'),(36192,61442,'cardiac muscle cell fate determination','P','The process involved in cardiac muscle cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.','2013-10-27','NSRP'),(36193,61443,'endocardial cushion cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cushion cell.','2013-10-27','NSRP'),(36194,61444,'endocardial cushion cell development','P','The process whose specific outcome is the progression of an endocardial cushion cell over time, from its formation to the mature state.','2013-10-27','NSRP'),(36195,61445,'endocardial cushion cell fate commitment','P','The commitment of a cell to an endocardial cushion cell fate and its capacity to differentiate into an endocardial cushion cell.','2013-10-27','NSRP'),(36196,61446,'endocardial cushion cell fate determination','P','The process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.','2013-10-27','NSRP'),(36197,61447,'endocardial cushion cell fate specification','P','The process involved in the specification of endocardial cushion cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.','2013-10-27','NSRP'),(36198,61448,'connective tissue development','P','The progression of a connective tissue over time, from its formation to the mature structure.','2013-10-27','NSRP'),(36199,61449,'olfactory bulb tufted cell development','P','The process whose specific outcome is the progression of an olfactory bulb tufted cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.','2013-10-27','NSRP'),(36200,61450,'trophoblast cell migration','P','Trophoblast cell migration that is accomplished by extension and retraction of a pseudopodium. Trophoblast cells line the outside of the blastocyst.','2013-10-27','NSRP'),(36201,61451,'retrotrapezoid nucleus development','P','The progression of the retrotrapezoid nucleus (RTN) over time from it\'s initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration.','2013-10-27','NSRP'),(36202,61452,'retrotrapezoid nucleus neuron differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the retrotrapezoid nucleus.','2013-10-27','NSRP'),(36203,61453,'interstitial cell of Cajal differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction.','2013-10-27','NSRP'),(36204,61454,'Golgi calcium ion export','P','The directed movement of calcium ions (Ca2+) out of the Golgi apparatus into the cytosol.','2013-10-27','NSRP'),(36205,61455,'integral to muscle cell projection membrane','C','Penetrating at least one phospholipid bilayer of a muscle cell projection membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(36206,61456,'mesenchymal stem cell migration involved in uteric bud morphogenesis','P','The orderly movement of a mesenchymal stem cell from one site to another contributing to the shaping of the ureteric bud. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.','2013-10-27','NSRP'),(36207,61457,'mesonephric cell migration involved in male gonad development','P','The orderly movement of a cell from the mesonephros to the male gonad, contributing to its development.','2013-10-27','NSRP'),(36208,61458,'reproductive system development','P','The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.','2013-10-27','NSRP'),(36209,61459,'L-arginine transmembrane transporter activity','F','Catalysis of the stereospecific transfer of L-arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane.','2013-10-27','NSRP'),(36210,61460,'L-histidine import','P','The directed movement of L-histidine into a cell or organelle.','2013-10-27','NSRP'),(36211,61461,'L-lysine import','P','The directed movement of L-lysine into a cell or organelle.','2013-10-27','NSRP'),(36212,61462,'protein localization to lysosome','P','A process in which a protein is transported to, or maintained in, a location within a lysosome.','2013-10-27','NSRP'),(36213,61463,'O-acetyl-ADP-ribose deacetylase activity','F','Catalysis of the reaction O-acetyl-ADP-ribose + H2O = ADP-ribose + acetate.','2013-10-27','NSRP'),(36214,61464,'plasma membrane part of cell-substrate junction.','C','The part of the plasma membrane that contributes to the structure of a cell-substrate junction.','2013-10-27','NSRP'),(36215,61465,'plasma membrane part of hemidesmosome','C','The part of the plasma membrane that contributes to the structure of a hemidesmosome.','2013-10-27','NSRP'),(36216,61466,'plasma membrane part of cell junction','C','The part of the plasma membrane that contributes to the structure of a cell junction.','2013-10-27','NSRP'),(36217,61467,'basolateral protein localization','P','Any process in which a protein is transported to, or maintained in, basolateral regions of the cell.','2013-10-27','NSRP'),(36218,61468,'karyomere','C','A membrane-bound intermediate cleavage-stage structure of individual or groups of chromosomes that coalesces and fuses with other karyomeres to form a nucleus during interphase. Karyomere formation occurs in blastomeres undergoing rapid cell division.','2013-10-27','NSRP'),(36219,61469,'regulation of type B pancreatic cell proliferation','P','Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.','2013-10-27','NSRP'),(36220,61470,'T follicular helper cell differentiation','P','The process in which a relatively unspecialized T cell acquires specialized features of a mature T follicular helper cell.','2013-10-27','NSRP'),(36221,61471,'karyomere assembly','P','The process where the nuclear membrane engulfs condensed chromosomes to form karyomeres during M phase of the mitotic cell cycle.','2013-10-27','NSRP'),(36222,61472,'karyomere membrane fusion','P','Process whereby karyomere membranes fuse during interphase to form a single lobed nucleus.','2013-10-27','NSRP'),(36223,61473,'murein tripeptide carboxypeptidase activity','F','Catalysis of the reaction L-Ala-gamma;-D-Glu-meso-Dap (murein tripeptide) + H2O = L-Ala-&gamma;-D-Glu + meso-diaminopimelate.','2013-10-27','NSRP'),(36224,61474,'phagolysosome membrane','C','The lipid bilayer surrounding a phagolysosome.','2013-10-27','NSRP'),(36225,61475,'cytosolic valyl-tRNA aminoacylation','P','The process of coupling valine to valyl-tRNA in the cytosol, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2\'- or the 3\'-hydroxyl group of the 3\'-adenosine residue of the tRNA.','2013-10-27','NSRP'),(36226,61476,'response to anticoagulant','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticoagulant stimulus.','2013-10-27','NSRP'),(36227,61477,'response to aromatase inhibitor','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aromatase inhibitor stimulus.','2013-10-27','NSRP'),(36228,61478,'response to platelet aggregation inhibitor','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet aggregation inhibitor stimulus.','2013-10-27','NSRP'),(36229,61479,'response to reverse transcriptase inhibitor','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reverse transcriptase inhibitor stimulus.','2013-10-27','NSRP'),(36230,61480,'response to asparaginase','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an asparaginase stimulus.','2013-10-27','NSRP'),(36231,61481,'response to TNF agonist','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a TNF agonist stimulus.','2013-10-27','NSRP'),(36232,61482,'response to irinotecan','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an irinotecan stimulus.','2013-10-27','NSRP'),(36233,61483,'sulfinylpropanyl adenylate synthase','F','Catalysis of the reaction: cysteine sulfanate + GTP + IMP = sulfinylpropanyl adenylate + GDP + 3 H(+) + phosphate.','2013-10-27','NSRP'),(36234,61484,'hematopoietic stem cell homeostasis','P','Any biological process involved in the maintenance of the steady-state number of hematopoietic stem cells within a population of cells.','2013-10-27','NSRP'),(36235,61485,'memory T cell proliferation','P','The expansion of a memory T cell population by cell division.','2013-10-27','NSRP'),(36236,61486,'high affinity fructose transmembrane transporter activity','F','Catalysis of the transfer of fructose from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.','2013-10-27','NSRP'),(36237,61487,'DNA replication initiation from late origin','P','The process in which DNA-dependent DNA replication is started at a late origin of replication. A late origin of replication refers to an origin that is activated late in S phase.','2013-10-27','NSRP'),(36238,61488,'adenine import into cell','P','The directed movement of adenine into a cell.','2013-10-27','NSRP'),(36239,61489,'guanine import into cell','P','The directed movement of guanine into a cell.','2013-10-27','NSRP'),(36240,61490,'glucose import into cell','P','The directed movement of glucose into a cell.','2013-10-27','NSRP'),(36241,61491,'serine import into cell','P','The directed movement of serine into a cell.','2013-10-27','NSRP'),(36242,61492,'asymmetric protein localization to old or new spindle pole body','P','Any process in which a protein is transported to, or maintained to either the old or new spindle pole body resulting in its being distributed asymmetrically.','2013-10-27','NSRP'),(36243,61493,'central plaque of mitotic spindle pole body','C','One of three laminate structures that form the mitotic spindle pole body; the central plaque is embedded in the nuclear envelope.','2013-10-27','NSRP'),(36244,61494,'gamma-tubulin large complex, mitotic spindle pole body','C','A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes located in the mitotic spindle pole body.','2013-10-27','NSRP'),(36245,61495,'gamma-tubulin small complex, mitotic spindle pole body','C','A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the mitotic spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(36246,61496,'half bridge of mitotic spindle pole body','C','Structure adjacent to the plaques of the mitotic spindle pole body.','2013-10-27','NSRP'),(36247,61497,'inner plaque of mitotic spindle pole body','C','One of three laminate structures that form the mitotic spindle pole body; the inner plaque is in the nucleus.','2013-10-27','NSRP'),(36248,61498,'intermediate layer of mitotic spindle pole body','C','Structure between the central and outer plaques of the mitotic spindle pole body.','2013-10-27','NSRP'),(36249,61499,'outer plaque of mitotic spindle pole body','C','One of three laminate structures that form the mitotic spindle pole body; the outer plaque is in the cytoplasm.','2013-10-27','NSRP'),(36250,61500,'gene conversion at mating-type locus, termination of copy-synthesis','P','A DNA replication termination process that is part of gene conversion at a mating-type locus and takes place at a specific termination site.','2013-10-27','NSRP'),(36251,61501,'cyclic-GMP-AMP synthase activity','F','Catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP.','2013-10-27','NSRP'),(36252,61502,'early endosome to recycling endosome transport','P','The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes.','2013-10-27','NSRP'),(36253,61503,'tRNA threonylcarbamoyladenosine dehydratase','F','Catalysis of the ATP-dependent dehydration of t6A to form cyclic t6A.','2013-10-27','NSRP'),(36254,61504,'cyclic threonylcarbamoyladenosine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cyclic threonylcarbamoyladenosine, a modified nucleoside found in some tRNA molecules.','2013-10-27','NSRP'),(36255,61505,'DNA topoisomerase II activity','F','Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; changes the linking number in multiples of 2.','2013-10-27','NSRP'),(36256,61506,'DNA topoisomerase type II (ATP-independent) activity','F','Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is not coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.','2013-10-27','NSRP'),(36257,61507,'cyclic-GMP-AMP binding','F','Interacting selectively and non-covalently with cyclic-GMP-AMP (cGAMP) cyclic nucleotide.','2013-10-27','NSRP'),(36258,61508,'CDP phosphorylation','P','The process of introducing a phosphate group into CDP to produce a CTP.','2013-10-27','NSRP'),(36259,61509,'asymmetric protein localization to old mitotic spindle pole body','P','Any process in which a protein is transported to, or maintained to the old mitotic spindle pole body resulting in its being distributed asymmetrically.','2013-10-27','NSRP'),(36260,61510,'asymmetric protein localization to new mitotic spindle pole body','P','Any process in which a protein is transported to, or maintained to the new mitotic spindle pole body resulting in its being distributed asymmetrically.','2013-10-27','NSRP'),(36261,61511,'centriole elongation','P','The centrosome organization process by which a centriole increases in length as part of the process of replication.','2013-10-27','NSRP'),(36262,61512,'protein localization to cilium','P','A process in which a protein is transported to, or maintained in, a location within a cilium.','2013-10-27','NSRP'),(36263,72692,'chromatin silencing at centromere central core','P','Repression of transcription of DNA at the central core of a regional centromere by altering the structure of chromatin.','2013-10-27','NSRP'),(36264,72693,'protein targeting to prospore membrane','P','The process of directing proteins towards the prospore membrane; usually uses signals contained within the protein.','2013-10-27','NSRP'),(36265,72694,'cell cycle arrest in response to caffeine','P','The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a caffeine stimulus.','2013-10-27','NSRP'),(36266,72695,'regulation of DNA recombination at telomere','P','Any process that modulates the frequency, rate or extent of DNA recombination within the telomere.','2013-10-27','NSRP'),(36267,72696,'positive regulation of DNA recombination at telomere','P','Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the telomere.','2013-10-27','NSRP'),(36268,72697,'protein localization to cell cortex','P','A process in which a protein is transported to, or maintained in, the cell cortex.','2013-10-27','NSRP'),(36269,72698,'protein localization to microtubule cytoskeleton','P','A cellular protein localization process in which a protein is transported to, or maintained at, a location within the microtubule cytoskeleton.','2013-10-27','NSRP'),(36270,72699,'protein localization to cortical microtubule cytoskeleton','P','A process in which a protein is transported to, or maintained at, a location within the cortical microtubule cytoskeleton.','2013-10-27','NSRP'),(36271,72700,'response to bismuth','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus.','2013-10-27','NSRP'),(36272,72701,'cellular response to bismuth','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bismuth (Bi) stimulus.','2013-10-27','NSRP'),(36273,72702,'response to methyl methanesulfonate','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus.','2013-10-27','NSRP'),(36274,72703,'cellular response to methyl methanesulfonate','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methyl methanesulfonate (MMS) stimulus.','2013-10-27','NSRP'),(36275,72704,'response to mercaptoethanol','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus.','2013-10-27','NSRP'),(36276,72705,'cellular response to mercaptoethanol','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercaptoethanol stimulus.','2013-10-27','NSRP'),(36277,72706,'response to sodium dodecyl sulfate','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus.','2013-10-27','NSRP'),(36278,72707,'cellular response to sodium dodecyl sulfate','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium dodecyl sulfate (SDS) stimulus.','2013-10-27','NSRP'),(36279,72708,'response to sorbitol','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus.','2013-10-27','NSRP'),(36280,72709,'cellular response to sorbitol','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus.','2013-10-27','NSRP'),(36281,72710,'response to hydroxyurea','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.','2013-10-27','NSRP'),(36282,72711,'cellular response to hydroxyurea','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroxyurea stimulus.','2013-10-27','NSRP'),(36283,72712,'response to thiabendazole','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus.','2013-10-27','NSRP'),(36284,72713,'cellular response to thiabendazole','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thiabendazole stimulus.','2013-10-27','NSRP'),(36285,72714,'response to selenite ion','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus.','2013-10-27','NSRP'),(36286,72715,'cellular response to selenite ion','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a selenite ion stimulus.','2013-10-27','NSRP'),(36287,72716,'response to actinomycin D','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus.','2013-10-27','NSRP'),(36288,72717,'cellular response to actinomycin D','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an actinomycin D stimulus.','2013-10-27','NSRP'),(36289,72718,'response to cisplatin','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.','2013-10-27','NSRP'),(36290,72719,'cellular response to cisplatin','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.','2013-10-27','NSRP'),(36291,72720,'response to dithiothreitol','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus.','2013-10-27','NSRP'),(36292,72721,'cellular response to dithiothreitol','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dithiothreitol stimulus.','2013-10-27','NSRP'),(36293,72722,'response to amitrole','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus.','2013-10-27','NSRP'),(36294,72723,'cellular response to amitrole','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amitrole stimulus.','2013-10-27','NSRP'),(36295,72724,'response to 4-nitroquinoline N-oxide','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus.','2013-10-27','NSRP'),(36296,72725,'cellular response to 4-nitroquinoline N-oxide','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 4-nitroquinoline N-oxide stimulus.','2013-10-27','NSRP'),(36297,72726,'response to CCCP','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus.','2013-10-27','NSRP'),(36298,72727,'cellular response to CCCP','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a CCCP stimulus.','2013-10-27','NSRP'),(36299,72728,'response to Gentian violet','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus.','2013-10-27','NSRP'),(36300,72729,'cellular response to Gentian violet','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a Gentian violet stimulus.','2013-10-27','NSRP'),(36301,72730,'response to papulacandin B','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus.','2013-10-27','NSRP'),(36302,72731,'cellular response to papulacandin B','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a papulacandin B stimulus.','2013-10-27','NSRP'),(36303,72732,'cellular response to calcium ion starvation','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of calcium ions.','2013-10-27','NSRP'),(36304,72733,'response to staurosporine','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus.','2013-10-27','NSRP'),(36305,72734,'cellular response to staurosporine','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus.','2013-10-27','NSRP'),(36306,72735,'response to t-BOOH','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus.','2013-10-27','NSRP'),(36307,72736,'cellular response to t-BOOH','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tert-butyl hydroperoxide (t-BOOH) stimulus.','2013-10-27','NSRP'),(36308,72737,'response to diamide','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N\',N\'-tetramethyldiazene-1,2-dicarboxamide) stimulus.','2013-10-27','NSRP'),(36309,72738,'cellular response to diamide','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diamide (N,N,N\',N\'-tetramethyldiazene-1,2-dicarboxamide) stimulus.','2013-10-27','NSRP'),(36310,72739,'response to anisomycin','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus.','2013-10-27','NSRP'),(36311,72740,'cellular response to anisomycin','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus.','2013-10-27','NSRP'),(36312,72741,'protein localization to cell division site','P','A cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division.','2013-10-27','NSRP'),(36313,72742,'SAGA complex localization to transcription regulatory region','P','Any process in which a SAGA complex is transported to, or maintained in, a specific location in the transcription regulatory region of a gene.','2013-10-27','NSRP'),(36314,72743,'cellular response to erythromycin','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythromycin stimulus.','2013-10-27','NSRP'),(36315,72744,'cellular response to trichodermin','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus.','2013-10-27','NSRP'),(36316,72745,'cellular response to antimycin A','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimycin A stimulus.','2013-10-27','NSRP'),(36317,72746,'cellular response to tetracycline','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tetracycline stimulus.','2013-10-27','NSRP'),(36318,72747,'cellular response to chloramphenicol','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chloramphenicol stimulus.','2013-10-27','NSRP'),(36319,72748,'cellular response to tacrolimus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus.','2013-10-27','NSRP'),(36320,72749,'cellular response to cytochalasin B','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytochalasin B stimulus.','2013-10-27','NSRP'),(36321,72750,'cellular response to leptomycin B','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptomycin B stimulus.','2013-10-27','NSRP'),(36322,72751,'cellular response to L-thialysine','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-thialysine stimulus.','2013-10-27','NSRP'),(36323,72752,'cellular response to rapamycin','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rapamycin stimulus.','2013-10-27','NSRP'),(36324,72753,'cellular response to glutathione','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glutathione stimulus.','2013-10-27','NSRP'),(36325,72754,'cellular response to purvalanol A','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purvalanol A stimulus.','2013-10-27','NSRP'),(36326,72755,'cellular response to benomyl','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus.','2013-10-27','NSRP'),(36327,72756,'cellular response to paraquat','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a paraquat stimulus.','2013-10-27','NSRP'),(36328,72757,'cellular response to camptothecin','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a camptothecin stimulus.','2013-10-27','NSRP'),(36329,72758,'response to topoisomerase inhibitor','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus.','2013-10-27','NSRP'),(36330,72759,'cellular response to topoisomerase inhibitor','P','Any process that results in a change in state or activity of a (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a topoisomerase inhibitor stimulus.','2013-10-27','NSRP'),(36331,72760,'cellular response to GW 7647','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a GW 7647 stimulus.','2013-10-27','NSRP'),(36332,72761,'cellular response to capsazepine','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus.','2013-10-27','NSRP'),(36333,72762,'cellular response to carbendazim','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbendazim stimulus.','2013-10-27','NSRP'),(36334,72763,'cellular response to hesperadin','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hesperadin stimulus.','2013-10-27','NSRP'),(36335,72764,'cellular response to reversine','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reversine stimulus.','2013-10-27','NSRP'),(36336,72765,'kinetochore localization','P','A cellular localization process in which a kinetochore is transported to, or maintained in, a specific location.','2013-10-27','NSRP'),(36337,72766,'centromere clustering at the nuclear periphery','P','A cellular localization process in which kinetochores/centromeres are transported to or maintained in the nuclear periphery. This process is responsible for the Rabl-like configuration of chromosomes in the interphase nuclei. In fission yeast this occurs at a location near the old mitotic spindle pole body.','2013-10-27','NSRP'),(36338,75501,'viral entry into host cell via caveolin-mediated endocytosis followed by membrane fusion with the endosome membrane','P','The uptake of a virus into a host cell that begins when material is taken up into plasma membrane caveolae which then pinch off to form endocytic caveolar carriers containing the virus. The caveolar carriers then deliver their viral content to early endosomes, and ends when the viral nucleic acid is released into the host cytoplasm when the viral membrane fuses with the endosomal membrane.','2013-09-22','NSRP'),(36339,75502,'endosome membrane permeabilization involved in viral entry into host cell','P','Induction of endosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus through the endosomal pathway, and results in delivery of the virus contents into the host cell cytoplasm.','2013-10-27','NSRP'),(36340,75503,'fusion of virus membrane with host macropinosome membrane','P','Fusion of a viral membrane with a host macropinosome membrane, that occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents into the host cell cytoplasm.','2013-10-27','NSRP'),(36341,75504,'macropinosomal membrane permeabilization involved in viral entry into host cell','P','Induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm.','2013-10-27','NSRP'),(36342,75505,'entry of intact viral capsid into host nucleus through nuclear pore complex','P','Viral penetration into the host nucleus where a viral capsid passes intact through the host nuclear pore complex (NPC).','2013-10-27','NSRP'),(36343,75506,'entry of viral genome into host nucleus through nuclear pore complex via importin','P','Viral penetration into the host nucleus where the viral genome passes through the nuclear pore complex (NPC) using the cellular importin transport machinery.','2013-10-27','NSRP'),(36344,75507,'entry of viral genome into host nucleus via docking of viral capsid to the nuclear pore complex and injection of viral genome','P','Viral penetration into the host nucleus where the where a viral capsid docks on the cytoplasmic side of the nuclear pore complex (NPC) and ejects the viral genome through the pore into the nucleoplasm.','2013-10-27','NSRP'),(36345,75508,'entry of viral genome into host nucleus via retainment of capsid in nuclear pore complex and release of genome into nucleoplasm','P','Viral penetration into the host nucleus where a viral capsid enters the host nuclear pore complex (NPC) but remains attached to the pore on the nuclear side. The capsid then disassembles, releasing the viral genome into the nucleoplasm.','2013-10-27','NSRP'),(36346,75509,'endocytosis involved in viral entry into host cell','P','Any endocytosis that is involved in the uptake of a virus into a host cell.','2013-10-27','NSRP'),(36347,75510,'macropinocytosis involved in viral entry into host cell','P','Any macropinocytosis that is involved in the uptake of a virus into a host cell.','2013-10-27','NSRP'),(36348,75511,'macropinosome lysis involved in viral entry into host cell','P','Viral-induced lysis of the macropinosome involved in the uptake of a virus into a host cell. Occurs after internalization of the virus in a macropinosome, and results in the release of viral contents from the macropinosome into the host cell cytoplasm.','2013-10-27','NSRP'),(36349,75512,'clathrin-mediated endocytosis of virus by host cell','P','Any clathrin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicle containing the virus.','2013-10-27','NSRP'),(36350,75513,'caveolin-mediated endocytosis of virus by host cell','P','Any caveolin-mediated endocytosis that is involved in the uptake of a virus into a host cell. Begins when material is taken up into plasma membrane caveolae - specialized lipid rafts that form 50-70 nm flask-shaped invaginations of the plasma membrane - which then pinch off to form endocytic caveolar carriers containing the virus.','2013-10-27','NSRP'),(36351,75514,'endosome lysis involved in viral entry into host cell','P','Viral-induced lysis of the endosome involved in uptake of a virus into a host cell. Occurs after internalization of the virus through the endosomal pathway, and results in release of the viral contents from the endosome into the host cell cytoplasm.','2013-10-27','NSRP'),(36352,75515,'viral entry into host cell via caveolin-mediated endocytosis followed by genetic injection through the endosome membrane','P','OBSOLETE. The uptake of a virus into a host cell that begins when material is taken up into plasma membrane caveolae which then pinch off to form endocytic caveolar carriers containing the virus. The caveolar carriers then deliver their viral content to early endosomes, and the process ends when viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane.','2013-10-27','NSRP'),(36353,75516,'viral entry into host cell via clathrin-mediated endocytosis followed by endosome lysis','P','The uptake of a virus into a host cell that begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicles containing the virus. The vesicle then delivers its viral content to early endosomes, and the process ends when viral nucleic acid is released into the host cytoplasm by viral-induced lysis of the endosome.','2013-09-22','NSRP'),(36354,75517,'viral entry into host cell via clathrin-mediated endocytosis followed by membrane fusion with the endosome membrane','P','The uptake of a virus into a host cell that begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicles containing the virus. The vesicle then delivers its viral content to early endosomes, and ends when the viral nucleic acid is released into the host cytoplasm when the viral membrane fuses with the endosomal membrane.','2013-09-22','NSRP'),(36355,75518,'viral entry into host cell via clathrin-mediated endocytosis followed by endosome membrane permeabilization','P','The uptake of a virus into a host cell that begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicles containing the virus. The vesicle then delivers its viral content to early endosomes, and the process ends when viral nucleic acid is released into the host cytoplasm by induction of endosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid.','2013-09-22','NSRP'),(36356,75519,'microtubule-dependent intracellular transport of viral material','P','The directed movement of the viral genome or viral particle within the host cell cytoplasm along host microtubules. Microtubule-dependent transport involves motor proteins like dynein and kinesin and is mostly used by viruses that target their genomes to the nucleus.','2013-10-27','NSRP'),(36357,75520,'actin-dependent intracellular transport of viral material','P','The directed movement of the viral genome or viral particle within the host cell cytoplasm via the host\'s actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions.','2013-10-27','NSRP'),(36358,75521,'microtubule-dependent intracellular transport of viral material towards nucleus','P','The directed movement of the viral genome or a viral particle towards the host cell nucleus using host microtubules.','2013-10-27','NSRP'),(36359,75529,'establishment of latency as a circular episome','P','A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a circular structure.','2013-10-27','NSRP'),(36360,75530,'establishment of latency as a linear episome','P','A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as linear structure.','2013-10-27','NSRP'),(36361,75606,'transport of viral material towards nucleus','P','The directed movement of the viral genome or a viral particle towards the host cell nucleus. The process begins after viral entry, and ends when the viral material is at the nuclear membrane.','2013-10-27','NSRP'),(36362,75705,'viral entry into host cell via clathrin-mediated endocytosis followed by genetic injection through the endosome membrane','P','OBSOLETE. The uptake of a virus into a host cell that begins by invagination of a specific region of the host cell plasma membrane around the bound virus to form a clathrin-coated pit, which then pinches off to form a clathrin-coated endocytic vesicles containing the virus. The vesicle then delivers its viral content to early endosomes, and the process ends when the viral nucleic acid is released into the host cytoplasm by its injection through the endosome membrane.','2013-10-27','NSRP'),(36363,75713,'establishment of integrated proviral latency','P','A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.','2013-10-27','NSRP'),(36364,75720,'establishment of episomal latency','P','A process by which a virus establishes a latent state within its host as an episome, where the viral genome remains silent in the cytoplasm or nucleus as a distinct genetic entity.','2013-10-27','NSRP'),(36365,75732,'viral penetration into host nucleus','P','The crossing by the virus of the host nuclear membrane, either as naked viral genome or for small viruses as an intact capsid.','2013-10-27','NSRP'),(36366,75733,'intracellular transport of viral material','P','The directed movement of the viral genome or the intact virus within the host cell.','2013-10-27','NSRP'),(36367,80187,'floral organ senescence','P','An organ senescence that has as a participant a floral organ.','2013-10-27','NSRP'),(36368,80188,'RNA-directed DNA methylation','P','An epigenetic RNA-based gene silencing process first elucidated in plants whereby 24-nt small interfering RNAs (siRNAs) guide DNA methyltransferases to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci.','2013-10-27','NSRP'),(36369,80189,'primary growth','P','Growth of a plant structure from the time of its initiation by an apical meristem until its expansion is completed.','2013-10-27','NSRP'),(36370,80190,'lateral growth','P','Growth of a plant axis (shoot axis or root) that originates from a lateral meristem.','2013-10-27','NSRP'),(36371,80191,'secondary thickening','P','Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from formation of tissue from a secondary thickening meristem.','2013-10-27','NSRP'),(36372,80192,'primary thickening','P','Lateral growth of a plant axis (shoot axis or root) that is an increase in thickness resulting from the activity of a primary thickening meristem.','2013-10-27','NSRP'),(36373,80193,'diffuse secondary thickening','P','Lateral growth of the older parts of a stem that occurs when the central parenchyma cells and the not yet fully differentiated fiber cells of the bundle sheaths continue to undergo cell division and expansion for a long period of time, leading to an increase in girth of the stem.','2013-10-27','NSRP'),(36374,86001,'regulation of cardiac muscle cell action potential','P','Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.','2013-10-27','NSRP'),(36375,86002,'regulation of cardiac muscle cell action potential involved in contraction','P','Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell contributing to the regulation of its contraction. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.','2013-10-27','NSRP'),(36376,86003,'cardiac muscle cell contraction','P','The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a cardiac muscle cell.','2013-10-27','NSRP'),(36377,86004,'regulation of cardiac muscle cell contraction','P','Any process that modulates the frequency, rate or extent of cardiac muscle cell contraction.','2013-10-27','NSRP'),(36378,86005,'regulation of ventricular cardiac muscle cell action potential','P','Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a ventricular cardiac muscle cell contributing to the regulation of its contraction. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.','2013-10-27','NSRP'),(36379,86006,'voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential','F','Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36380,86007,'voltage-gated calcium channel activity involved in regulation of cardiac muscle cell action potential','F','Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36381,86008,'voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization','F','Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36382,86009,'membrane repolarization','P','The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the resting potential. For example, the repolarization during an action potential is in the direction from the positive membrane potential towards the negative resting potential.','2013-10-27','NSRP'),(36383,86010,'membrane depolarization involved in regulation of action potential','P','The process in which membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.','2013-10-27','NSRP'),(36384,86011,'membrane repolarization involved in regulation of action potential','P','The process in which ions are transported across a membrane such that the membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.','2013-10-27','NSRP'),(36385,86012,'membrane depolarization involved in regulation of cardiac muscle cell action potential','P','The process in which cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.','2013-10-27','NSRP'),(36386,86013,'membrane repolarization involved in regulation of cardiac muscle cell action potential','P','The process in which ions are transported across a membrane such that the cardiac muscle cell plasma membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.','2013-10-27','NSRP'),(36387,86014,'regulation of atrial cardiac muscle cell action potential','P','Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrial cardiac muscle cell contributing to the regulation of its contraction. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.','2013-10-27','NSRP'),(36388,86015,'regulation of SA node cell action potential','P','Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an SA node cardiac myocyte. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.','2013-10-27','NSRP'),(36389,86016,'regulation of AV node cell action potential','P','Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in an atrioventricular node myocyte. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.','2013-10-27','NSRP'),(36390,86017,'regulation of Purkinje myocyte action potential','P','Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a Purkinje myocyte. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.','2013-10-27','NSRP'),(36391,86018,'SA node cell to atrial cardiac muscle cell signalling','P','Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte.','2013-10-27','NSRP'),(36392,86019,'cell-cell signaling involved in cardiac conduction','P','Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.','2013-10-27','NSRP'),(36393,86020,'gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling','F','A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.','2013-10-27','NSRP'),(36394,86021,'SA node cell to atrial cardiac muscle cell communication by electrical coupling','P','The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels.','2013-10-27','NSRP'),(36395,86022,'SA node cell-atrial cardiac muscle cell adhesion involved in cell communication','P','The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.','2013-10-27','NSRP'),(36396,86023,'adrenergic receptor signaling pathway involved in heart process','P','A series of molecular signals beginning with a G-protein coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, which contributes to a circulatory system process carried out by the heart.','2013-10-27','NSRP'),(36397,86024,'adrenergic receptor signaling pathway involved in positive regulation of heart rate','P','An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate.','2013-10-27','NSRP'),(36398,86026,'atrial cardiac muscle cell to AV node cell signaling','P','Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell.','2013-10-27','NSRP'),(36399,86027,'AV node cell to bundle of His cell signaling','P','Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.','2013-10-27','NSRP'),(36400,86028,'bundle of His cell to Purkinje myocyte signaling','P','Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte.','2013-10-27','NSRP'),(36401,86029,'Purkinje myocyte to ventricular cardiac muscle cell signaling','P','Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.','2013-10-27','NSRP'),(36402,86030,'adrenergic receptor signaling pathway involved in cardiac muscle relaxation','P','An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.','2013-10-27','NSRP'),(36403,86033,'G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate','P','A G-protein coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G-protein coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate.','2013-10-27','NSRP'),(36404,86036,'regulation of cardiac muscle cell membrane potential','P','Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.','2013-10-27','NSRP'),(36405,86037,'sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell.','2013-10-27','NSRP'),(36406,86038,'calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell.','2013-10-27','NSRP'),(36407,86039,'calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential','F','Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell plasma membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans). The transfer contributes to the regulation of the plasma membrane potential.','2013-10-27','NSRP'),(36408,86040,'sodium:hydrogen antiporter activity involved in regulation of cardiac muscle cell membrane potential','F','Catalysis of the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential.','2013-10-27','NSRP'),(36409,86041,'voltage-gated potassium channel activity involved in SA node cell action potential depolarization','F','Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36410,86042,'cardiac muscle cell-cardiac muscle cell adhesion','P','The attachment of one cardiomyocyte to another cardiomyocyte via adhesion molecules.','2013-10-27','NSRP'),(36411,86043,'regulation of bundle of His cell action potential','P','Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell of the bundle of His. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.','2013-10-27','NSRP'),(36412,86044,'atrial cardiac muscle cell to AV node cell communication by electrical coupling','P','The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.','2013-10-27','NSRP'),(36413,86045,'membrane depolarization involved in regulation of AV node cell action potential','P','The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.','2013-10-27','NSRP'),(36414,86046,'membrane depolarization involved in regulation of SA node cell action potential','P','The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.','2013-10-27','NSRP'),(36415,86047,'membrane depolarization involved in regulation of Purkinje myocyte cell action potential','P','The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.','2013-10-27','NSRP'),(36416,86048,'membrane depolarization involved in regulation of bundle of His cell action potential','P','The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.','2013-10-27','NSRP'),(36417,86049,'membrane repolarization involved in regulation of AV node cell action potential','P','The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.','2013-10-27','NSRP'),(36418,86050,'membrane repolarization involved in regulation of bundle of His cell action potential','P','The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.','2013-10-27','NSRP'),(36419,86051,'membrane repolarization involved in regulation of Purkinje myocyte action potential','P','The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.','2013-10-27','NSRP'),(36420,86052,'membrane repolarization involved in regulation of SA node cell action potential','P','The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.','2013-10-27','NSRP'),(36421,86053,'AV node cell to bundle of His cell communication by electrical coupling','P','The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.','2013-10-27','NSRP'),(36422,86054,'bundle of His cell to Purkinje myocyte communication by electrical coupling','P','The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels.','2013-10-27','NSRP'),(36423,86055,'Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling','P','The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.','2013-10-27','NSRP'),(36424,86056,'voltage-gated calcium channel activity involved in regulation of AV node cell action potential','F','Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36425,86057,'voltage-gated calcium channel activity involved in regulation of bundle of His cell action potential','F','Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36426,86058,'voltage-gated calcium channel activity involved in regulation of Purkinje myocyte cell action potential','F','Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36427,86059,'voltage-gated calcium channel activity involved in regulation of SA node cell action potential','F','Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36428,86060,'voltage-gated sodium channel activity involved in regulation of AV node cell action potential','F','Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36429,86061,'voltage-gated sodium channel activity involved in regulation of bundle of His cell action potential','F','Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36430,86062,'voltage-gated sodium channel activity involved in regulation of Purkinje myocyte action potential','F','Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36431,86063,'voltage-gated sodium channel activity involved in regulation of SA node cell action potential','F','Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36432,86064,'cell communication by electrical coupling involved in cardiac conduction','P','The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.','2013-10-27','NSRP'),(36433,86065,'cell communication involved in cardiac conduction','P','Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.','2013-10-27','NSRP'),(36434,86066,'atrial cardiac muscle cell to AV node cell communication','P','The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.','2013-10-27','NSRP'),(36435,86067,'AV node cell to bundle of His cell communication','P','The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.','2013-10-27','NSRP'),(36436,86068,'Purkinje myocyte to ventricular cardiac muscle cell communication','P','The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.','2013-10-27','NSRP'),(36437,86069,'bundle of His cell to Purkinje myocyte communication','P','The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.','2013-10-27','NSRP'),(36438,86070,'SA node cell to atrial cardiac muscle cell communication','P','The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.','2013-10-27','NSRP'),(36439,86071,'atrial cardiac muscle cell-AV node cell adhesion involved in cell communication','P','The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.','2013-10-27','NSRP'),(36440,86072,'AV node cell-bundle of His cell adhesion involved in cell communication','P','The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.','2013-10-27','NSRP'),(36441,86073,'bundle of His cell-Purkinje myocyte adhesion involved in cell communication','P','The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.','2013-10-27','NSRP'),(36442,86074,'Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication','P','The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.','2013-10-27','NSRP'),(36443,86075,'gap junction channel activity involved in cardiac conduction electrical coupling','F','A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.','2013-10-27','NSRP'),(36444,86076,'gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling','F','A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.','2013-10-27','NSRP'),(36445,86077,'gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling','F','A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.','2013-10-27','NSRP'),(36446,86078,'gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling','F','A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.','2013-10-27','NSRP'),(36447,86079,'gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling','F','A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.','2013-10-27','NSRP'),(36448,86080,'protein binding involved in heterotypic cell-cell adhesion','F','Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells.','2013-10-27','NSRP'),(36449,86081,'cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication','F','Interacting selectively and non-covalently with any protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells.','2013-10-27','NSRP'),(36450,86082,'cell adhesive protein binding involved in AV node cell-bundle of His cell communication','F','Interacting selectively and non-covalently with any protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells.','2013-10-27','NSRP'),(36451,86083,'cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication','F','Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.','2013-10-27','NSRP'),(36452,86084,'cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication','F','Interacting selectively and non-covalently with any protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells.','2013-10-27','NSRP'),(36453,86085,'cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication','F','Interacting selectively and non-covalently with any protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells.','2013-10-27','NSRP'),(36454,86086,'voltage-gated potassium channel activity involved in AV node cell action potential repolarization','F','Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36455,86087,'voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization','F','Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36456,86088,'voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization','F','Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36457,86089,'voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization','F','Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36458,86090,'voltage-gated potassium channel activity involved in SA node cell action potential repolarization','F','Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(36459,86091,'regulation of heart rate by cardiac conduction','P','A cardiac conduction process that modulates the frequency or rate of heart contraction.','2013-10-27','NSRP'),(36460,86092,'regulation of the force of heart contraction by cardiac conduction','P','A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled.','2013-10-27','NSRP'),(36461,86093,'G-protein coupled acetylcholine receptor signaling pathway involved in involved in heart process','P','A G-protein coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart.','2013-10-27','NSRP'),(36462,86094,'positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction','P','An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction.','2013-10-27','NSRP'),(36463,86095,'positive regulation of IKACh channel activity by G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate','P','A G-protein coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G-protein coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate.','2013-10-27','NSRP'),(36464,86096,'adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process','P','An adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart, where the activated adrenergic receptor transmits the signal by Gi-mediated inhibition of adenylate cyclase activity.','2013-10-27','NSRP'),(36465,86097,'phospholipase C-activating angiotensin-mediated signaling pathway','P','An angiotensin-mediated signaling pathway where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores.','2013-10-27','NSRP'),(36466,86098,'angiotensin-mediated signaling pathway involved in heart process','P','An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.','2013-10-27','NSRP'),(36467,86099,'phospholipase C-activating angiotensin-mediated signaling pathway involved in heart process','P','An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores.','2013-10-27','NSRP'),(36468,86100,'endothelin receptor signaling pathway','P','A series of molecular signals initiated by an endothelin receptor binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(36469,86101,'endothelin receptor signaling pathway involved in heart process','P','An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.','2013-10-27','NSRP'),(36470,86102,'adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate','P','A G-protein coupled acetylcholine receptor signaling pathway that contributes to an decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G-protein coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate.','2013-10-27','NSRP'),(36471,86103,'G-protein coupled receptor signaling pathway involved in heart process','P','An G-protein coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart.','2013-10-27','NSRP'),(36472,90412,'positive regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process','P','Any positive regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process.','2013-10-27','NSRP'),(36473,90413,'negative regulation of transcription from RNA polymerase II promoter involved in fatty acid biosynthetic process','P','Any negative regulation of transcription from RNA polymerase II promoter that is involved in fatty acid biosynthetic process.','2013-10-27','NSRP'),(36474,90414,'molybdate ion export from vacuole','P','The directed movement of molybdate ions out of the vacuole.','2013-10-27','NSRP'),(36475,90415,'7-hydroxymethyl chlorophyll a reductase activity','F','Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O.','2013-10-27','NSRP'),(36476,90416,'nicotinate transporter activity','F','Enables the directed movement of nicotinate into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(36477,90417,'N-methylnicotinate transporter activity','F','Enables the directed movement of N-methylnicotinate into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(36478,90418,'positive regulation of transcription involved in S-phase of mitotic cell cycle','P','OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the S phase of the mitotic cell cycle.','2013-10-27','NSRP'),(36479,90419,'negative regulation of transcription involved in G2/M transition of mitotic cell cycle','P','Any process that inhibits or decreases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle.','2013-10-27','NSRP'),(36480,90420,'naphthalene-containing compound metabolic process','P','The chemical reactions and pathways involving naphthalene-containing compounds.','2013-10-27','NSRP'),(36481,90421,'embryonic meristem initiation','P','Initiation of a region of tissue in a plant embryo that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation.','2013-10-27','NSRP'),(36482,90422,'thiamine pyrophosphate transporter activity','F','Enables the directed movement of thiamine pyrophosphate into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(36483,90423,'phytochelatin-metal complex formation','P','A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex.','2013-10-27','NSRP'),(36484,90424,'phytochelatin-metal-sulfur complex formation','P','A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex.','2013-10-27','NSRP'),(36485,90425,'acinar cell differentiation','P','The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini.','2013-10-27','NSRP'),(36486,90426,'actin filament bundle convergence','P','A process of actin filament bundle distribution that results in the compaction of actin filaments.','2013-10-27','NSRP'),(36487,90427,'activation of meiosis','P','Any process that starts the inactive process of meiosis.','2013-10-27','NSRP'),(36488,90428,'perianth development','P','The process whose specific outcome is the progression of the perianth over time, from its formation to the mature structure. The perianth is a collective phyllome structure composed of two or more petals, sepals, or tepals.','2013-10-27','NSRP'),(36489,90429,'detection of endogenous biotic stimulus','P','The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(36490,90430,'caffeoyl-CoA: alcohol caffeoyl transferase activity','F','Catalysis of the reaction: caffeoyl-CoA + a saturated primary alcohol = an alkyl caffeate + CoA.','2013-10-27','NSRP'),(36491,90431,'alkyl caffeate ester biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate.','2013-10-27','NSRP'),(36492,90432,'myristoyl-CoA ligase activity','F','Catalysis of the reaction: ATP + myristic acid + CoA = AMP + diphosphate + myristoyl-CoA.','2013-10-27','NSRP'),(36493,90433,'palmitoyl-CoA ligase activity','F','Catalysis of the reaction: ATP + palmitic acid + CoA = AMP + diphosphate + palmitoyl-CoA.','2013-10-27','NSRP'),(36494,90434,'oleoyl-CoA ligase activity','F','Catalysis of the reaction: ATP + oleic acid + CoA = AMP + diphosphate + oleoyl-CoA.','2013-10-27','NSRP'),(36495,90435,'protein localization to nuclear envelope','P','A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.','2013-10-27','NSRP'),(36496,90436,'leaf pavement cell development','P','The process whose specific outcome is the progression of an leaf pavement cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a leaf pavement cell fate.','2013-10-27','NSRP'),(36497,90437,'socket cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support.','2013-10-27','NSRP'),(36498,90438,'camelliol C synthase activity','F','Catalyzes the reaction: (3S)-2,3-epoxy-2,3-dihydrosqualene = camelliol C.','2013-10-27','NSRP'),(36499,90439,'tetraketide alpha-pyrone synthase activity','F','Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A .','2013-10-27','NSRP'),(36500,90440,'abscisic acid transporter activity','F','Enables the directed movement of abscisic acid into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(36501,90441,'trehalose biosynthesis in response to heat stress','P','The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.','2013-10-27','NSRP'),(36502,90442,'trehalose catabolism in response to heat stress','P','The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.','2013-10-27','NSRP'),(36503,90443,'FAR/SIN/STRIPAK complex','C','A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body.','2013-10-27','NSRP'),(36504,90444,'regulation of nematode larval development, heterochronic','P','Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached.','2013-10-27','NSRP'),(36505,90445,'positive regulation of nematode larval development, heterochronic','P','Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and increases the rate at which this time point is reached.','2013-10-27','NSRP'),(36506,90446,'negative regulation of nematode larval development, heterochronic','P','Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and decreases the rate at which this time point is reached.','2013-10-27','NSRP'),(36507,90447,'glycerol-3-phosphate 2-O-acyltransferase activity','F','Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate.','2013-10-27','NSRP'),(36508,90448,'glucosinolate:hydrogen symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in).','2013-10-27','NSRP'),(36509,90449,'phloem glucosinolate loading','P','The process of loading glucosinolates into the sieve tube or companion cell of the phloem for long distance transport from source to sink.','2013-10-27','NSRP'),(36510,90450,'inosine-diphosphatase activity','F','Catalysis of the reaction: IDP + H2O = IMP + phosphate.','2013-10-27','NSRP'),(36511,90451,'cotyledon boundary formation','P','The process in which boundaries between a cotyledon and the surrounding tissue are established and maintained.','2013-10-27','NSRP'),(36512,90452,'lithium ion import','P','The directed movement of lithium ions into a cell or organelle.','2013-10-27','NSRP'),(36513,90453,'aspartate transmembrane import into vacuole','P','The directed movement of aspartate into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36514,90454,'glutamate transmembrane import into vacuole','P','The directed movement of glutamate into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36515,90455,'ornithine transmembrane import into vacuole','P','The directed movement of ornithine into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36516,90456,'lysine transmembrane import into vacuole','P','The directed movement of lysine into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36517,90457,'histidine transmembrane import into vacuole','P','The directed movement of histidine into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36518,90458,'arginine transmembrane import into vacuole','P','The directed movement of arginine into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36519,90459,'aspartate homeostasis','P','Any process involved in the maintenance of an internal steady state of aspartate within an organism or cell.','2013-10-27','NSRP'),(36520,90460,'threonine homeostasis','P','Any process involved in the maintenance of an internal steady state of threonine within an organism or cell.','2013-10-27','NSRP'),(36521,90461,'glutamate homeostasis','P','Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell.','2013-10-27','NSRP'),(36522,90462,'ornithine homeostasis','P','Any process involved in the maintenance of an internal steady state of ornithine within an organism or cell.','2013-10-27','NSRP'),(36523,90463,'lysine homeostasis','P','Any process involved in the maintenance of an internal steady state of lysine within an organism or cell.','2013-10-27','NSRP'),(36524,90464,'histidine homeostasis','P','Any process involved in the maintenance of an internal steady state of histidine within an organism or cell.','2013-10-27','NSRP'),(36525,90465,'arginine homeostasis','P','Any process involved in the maintenance of an internal steady state of arginine within an organism or cell.','2013-10-27','NSRP'),(36526,90466,'histidine import','P','The directed movement of histidine into a cell or organelle.','2013-10-27','NSRP'),(36527,90467,'arginine import','P','The directed movement of arginine into a cell or organelle.','2013-10-27','NSRP'),(36528,90468,'valine import','P','The directed movement of valine into a cell or organelle.','2013-10-27','NSRP'),(36529,90469,'asparagine import','P','The directed movement of asparagine into a cell or organelle.','2013-10-27','NSRP'),(36530,90470,'shoot organ boundary specification','P','The process in which the basal boundary between the stem and both vegetative and reproductive organs are established and maintained.','2013-10-27','NSRP'),(36531,90471,'9,15,9\'-tri-cis-zeta-carotene isomerase activity','F','Catalysis of the reaction: 9,15,9\'-tricis-zeta-carotene = 9,9\'-dicis-zeta-carotene.','2013-10-27','NSRP'),(36532,90472,'dibasic protein processing','P','Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein.','2013-10-27','NSRP'),(36533,90473,'lys-arg specific dibasic protein processing','P','Any protein processing achieved by the cleavage of a peptide bond after a lysine-arginine amino acid residue combination within a protein.','2013-10-27','NSRP'),(36534,90474,'arg-arg specific dibasic protein processing','P','Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein.','2013-10-27','NSRP'),(36535,90475,'lys-lys specific dibasic protein processing','P','Any protein processing achieved by the cleavage of a peptide bond after two consecutive lysine amino acid residues within a protein.','2013-10-27','NSRP'),(36536,90476,'isoleucine import','P','The directed movement of isoleucine into a cell or organelle.','2013-10-27','NSRP'),(36537,90477,'L-isoleucine import','P','The directed movement of L-isoleucine, the L-enantiomer of isoleucine, into a cell or organelle.','2013-10-27','NSRP'),(36538,90478,'serine import','P','The directed movement of serine into a cell or organelle.','2013-10-27','NSRP'),(36539,90479,'L-serine import','P','The directed movement of L-serine, the L-enantiomer of serine, into a cell or organelle.','2013-10-27','NSRP'),(36540,90480,'purine nucleotide-sugar transmembrane transport','P','The directed movement of a purine nucleotide-sugar across a membrane. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.','2013-10-27','NSRP'),(36541,90481,'pyrimidine nucleotide-sugar transmembrane transport','P','The directed movement of pyrimidine nucleotide-sugars across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.','2013-10-27','NSRP'),(36542,90482,'vitamin transmembrane transporter activity','F','Enables the transfer of a vitamin from one side of a membrane to the other.','2013-10-27','NSRP'),(36543,90483,'phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity','F','Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine.','2013-10-27','NSRP'),(36544,90484,'drug transporter activity','F','Enables the directed movement of a drug into, out of or within a cell, or between cells. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.','2013-10-27','NSRP'),(36545,90485,'chromosome number maintenance','P','The maintenance of the standard number of chromosomes in a cell.','2013-10-27','NSRP'),(36546,90486,'small RNA 2\'-O-methyltransferase','F','Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in an small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA <=> S-adenosyl-L-homocysteine + small RNA containing a 3\'-terminal 2\'-O-methylnucleotide.','2013-10-27','NSRP'),(36547,90487,'secondary metabolite catabolic process','P','The chemical reactions and pathways resulting in the breakdown of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.','2013-10-27','NSRP'),(36548,90488,'polo box domain specific binding','F','Interacting selectively and non-covalently with a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases.','2013-10-27','NSRP'),(36549,90489,'L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)','F','Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O.','2013-10-27','NSRP'),(36550,90490,'L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)','F','Catalyzes the reaction: L-Tryptophan + Oxygen + NADPH + H+ = N-Hydroxy-L-tryptophan + NADP+ + H2O.','2013-10-27','NSRP'),(36551,90491,'N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)','F','Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O.','2013-10-27','NSRP'),(36552,90492,'N,N-Dihydroxy-L-tryptophan decarboxylase activity','F','Catalyzes the reaction: N,N-Dihydroxy-L-tryptophan = Indole-3-acetaldehyde oxime + CO2 + H2O.','2013-10-27','NSRP'),(36553,90493,'catecholamine uptake','P','The directed movement of catecholamine into a cell.','2013-10-27','NSRP'),(36554,90494,'dopamine uptake','P','The directed movement of dopamine into a cell.','2013-10-27','NSRP'),(36555,90495,'low-density lipoprotein particle disassembly','P','The disaggregation of a low-density lipoprotein particle into its constituent components.','2013-10-27','NSRP'),(36556,90496,'mesenchyme migration involved in limb bud formation','P','The migration of mesenchymal tissue that contributes to the formation of a limb bud.','2013-10-27','NSRP'),(36557,90497,'mesenchymal cell migration','P','The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism.','2013-10-27','NSRP'),(36558,90498,'extrinsic to Golgi membrane','C','Loosely bound to one surface of the Golgi membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(36559,90499,'pimelyl-[acyl-carrier protein] methyl ester esterase activity','F','Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol.','2013-10-27','NSRP'),(36560,90500,'endocardial cushion to mesenchymal transition','P','A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.','2013-10-27','NSRP'),(36561,90501,'RNA phosphodiester bond hydrolysis','P','The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis.','2013-10-27','NSRP'),(36562,90502,'RNA phosphodiester bond hydrolysis, endonucleolytic','P','The chemical reactions and pathways involving the hydrolysis of internal 3\',5\'-phosphodiester bonds in one or two strands of ribonucleotides.','2013-10-27','NSRP'),(36563,90503,'RNA phosphodiester bond hydrolysis, exonucleolytic','P','The chemical reactions and pathways involving the hydrolysis of terminal 3\',5\'-phosphodiester bonds in one or two strands of ribonucleotides.','2013-10-27','NSRP'),(36564,90504,'epiboly','P','The expansion of one cell sheet over other cells or yolk.','2013-10-27','NSRP'),(36565,90505,'epiboly involved in wound healing','P','The expansion of one cell sheet over other cells involved in wound healing.','2013-10-27','NSRP'),(36566,90506,'axillary shoot meristem initiation','P','A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf.','2013-10-27','NSRP'),(36567,90507,'phenylethylamine metabolic process involved in synaptic transmission','P','The chemical reactions and pathways involving phenylethylamine that contribute to synaptic transmission.','2013-10-27','NSRP'),(36568,90508,'phenylethylamine biosynthetic process involved in synaptic transmission','P','The chemical reactions and pathways resulting in the formation of phenylethylamine that contribute to synaptic transmission.','2013-10-27','NSRP'),(36569,90509,'nickel cation import into cell','P','The directed movement of nickel (Ni) cations into a cell.','2013-10-27','NSRP'),(36570,90510,'anticlinal cell division','P','A cell division process where the division plane is perpendicular to the surface of the organ. It adds cells to the existing cell layer or cell file.','2013-10-27','NSRP'),(36571,90511,'periclinal cell division','P','A cell division process where the division plane is parallel to the surface of the organ. It creates a new cell layer or cell file.','2013-10-27','NSRP'),(36572,90512,'eisosome membrane domain/MCC','C','A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins.','2013-10-27','NSRP'),(36573,90513,'L-histidine transmembrane import into vacuole','P','The directed movement of L-histidine into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36574,90514,'L-tyrosine transmembrane import into vacuole','P','The directed movement of L-tyrosine into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36575,90515,'L-glutamate transmembrane import into vacuole','P','The directed movement of L-glutamate into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36576,90516,'L-serine transmembrane import into vacuole','P','The directed movement of L-serine into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36577,90517,'L-lysine transmembrane import into vacuole','P','The directed movement of L-lysine into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36578,90518,'L-arginine transmembrane import into vacuole','P','The directed movement of L-arginine into the vacuole across the vacuolar membrane.','2013-10-27','NSRP'),(36579,90519,'anoxia protection','P','Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia.','2013-10-27','NSRP'),(36580,90520,'sphingolipid mediated signaling pathway','P','A series of molecular signals mediated by a sphingolipid.','2013-10-27','NSRP'),(36581,90521,'glomerular visceral epithelial cell migration','P','The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.','2013-10-27','NSRP'),(36582,90522,'vesicle tethering involved in exocytosis','P','The initial long-distance interaction between secretory vesicles and exocytotic sites on target membranes resulting in the capture and stabilization of vesicles prior to SNARE-mediated docking and fusion.','2013-10-27','NSRP'),(36583,90523,'cytochrome-b5 reductase activity, acting on NADPH','F','Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome b(5) = NADP+ + 2 ferrocytochrome b(5).','2013-10-27','NSRP'),(36584,90524,'cytochrome-b5 reductase activity, acting on NADH','F','Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5).','2013-10-27','NSRP'),(36585,90525,'regulation of glycolysis involved in cellular glucose homeostasis','P','Any process that modulates the frequency, rate or extent of glycolysis as an integral part of cellular glucose homeostasis.','2013-10-27','NSRP'),(36586,90526,'regulation of gluconeogenesis involved in cellular glucose homeostasis','P','Any process that modulates the frequency, rate or extent of gluconeogenesis as an integral part of cellular glucose homeostasis.','2013-10-27','NSRP'),(36587,90527,'actin filament reorganization','P','A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments.','2013-10-27','NSRP'),(36588,90528,'smooth septate junction assembly','P','The assembly of a smooth septate junction, a septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions.','2013-10-27','NSRP'),(36589,90529,'cell septum assembly','P','The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.','2013-10-27','NSRP'),(36590,90530,'cell septum assembly involved in cell cycle cytokinesis','P','A cell septum assembly process that occurs during, and contributes to, cytokinesis that occurs in the context of cell cycle progression.','2013-04-22','NSRP'),(36591,90531,'L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose','P','The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose.','2013-10-27','NSRP'),(36592,90532,'L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate','P','The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate.','2013-10-27','NSRP'),(36593,90533,'cation-transporting ATPase complex','C','Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).','2013-10-27','NSRP'),(36594,90534,'calcium ion-transporting ATPase complex','C','Protein complex that carries out the reaction: ATP + H2O + Ca2+(out) = ADP + phosphate + Ca2+(in).','2013-10-27','NSRP'),(36595,90535,'WICH complex','C','An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair.','2013-10-27','NSRP'),(36596,90536,'NoRC complex','C','An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters.','2013-10-27','NSRP'),(36597,90537,'CERF complex','C','An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters.','2013-10-27','NSRP'),(36598,90538,'peptide pheromone secretion','P','The regulated release of a peptide pheromone from a cell.','2013-10-27','NSRP'),(36599,90539,'peptide pheromone export by transmembrane transport','P','The directed movement of a peptide pheromone across a membrane and out of a cell.','2013-10-27','NSRP'),(36600,90540,'bacterial cellulose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria.','2013-10-27','NSRP'),(36601,90541,'MIT domain binding','F','Interacting selectively and non-covalently with the MIT domain of a protein. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.','2013-10-27','NSRP'),(36602,90542,'ELYC domain binding','F','Interacting selectively and non-covalently with the ELYC domain of a protein. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC.','2013-10-27','NSRP'),(36603,90543,'Flemming body','C','A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.','2013-10-27','NSRP'),(36604,90544,'BAF-type complex','C','A SWI/SNF-type complex that contains a subunit from the BAF (Brahma-Associated Factor) family.','2013-10-27','NSRP'),(36605,90545,'CHD-type complex','C','A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure.','2013-10-27','NSRP'),(36606,97152,'mesenchymal cell apoptotic process','P','Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.','2013-10-27','NSRP'),(36607,97153,'cysteine-type endopeptidase activity involved in apoptotic process','F','Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process.','2013-10-27','NSRP'),(36608,97154,'GABAergic neuron differentiation','P','The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron.','2013-10-27','NSRP'),(36609,97155,'fasciculation of sensory neuron axon','P','The collection of sensory neuron axons into a bundle of rods, known as a fascicle.','2013-10-27','NSRP'),(36610,97156,'fasciculation of motor neuron axon','P','The collection of motor neuron axons into a bundle of rods, known as a fascicle.','2013-10-27','NSRP'),(36611,97157,'pre-mRNA intronic binding','F','Interacting selectively and non-covalently with an intronic sequence of a pre-messenger RNA (pre-mRNA).','2013-10-27','NSRP'),(36612,97158,'pre-mRNA intronic pyrimidine-rich binding','F','Interacting selectively and non-covalently with a pyrimidine-rich (CU-rich) intronic sequence of a pre-messenger RNA (pre-mRNA).','2013-10-27','NSRP'),(36613,97159,'organic cyclic compound binding','F','Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.','2013-10-27','NSRP'),(36614,97160,'polychlorinated biphenyl binding','F','Interacting selectively and non-covalently with a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings.','2013-10-27','NSRP'),(36615,97161,'DH domain binding','F','Interacting selectively and non-covalently with a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.','2013-10-27','NSRP'),(36616,97162,'MADS box domain binding','F','Interacting selectively and non-covalently with a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs.','2013-10-27','NSRP'),(36617,97163,'sulfur carrier activity','F','Enables the directed movement of sulfur into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(36618,97164,'ammonium ion metabolic process','P','The chemical reactions and pathways involving the ammonium ion.','2013-10-27','NSRP'),(36619,97165,'nuclear stress granule','C','A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.','2013-10-27','NSRP'),(36620,97166,'lens epithelial cell proliferation','P','The multiplication or reproduction of lens epithelial cells, resulting in the expansion of a cell population. Lens epithelial cells make up the lens epithelium, which is located in the anterior portion of the lens between the lens capsule and the lens fibers and is a simple cuboidal epithelium. The epithelial cells of the lens regulate most of the homeostatic functions of the lens such as osmolarity and liquid volume. The lens epithelial cells also serve as the progenitors for new lens fibers. The lens epithelium constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.','2013-10-27','NSRP'),(36621,97167,'circadian regulation of translation','P','Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours.','2013-10-27','NSRP'),(36622,97168,'mesenchymal stem cell proliferation','P','The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.','2013-10-27','NSRP'),(36623,97169,'AIM2 inflammasome complex','C','A protein complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA.','2013-10-27','NSRP'),(36624,97170,'ADP-L-glycero-beta-D-manno-heptose metabolic process','P','The chemical reactions and pathways involving ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate.','2013-10-27','NSRP'),(36625,97171,'ADP-L-glycero-beta-D-manno-heptose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate.','2013-10-27','NSRP'),(36626,97172,'N-acetylmuramic acid metabolic process','P','The chemical reactions and pathways involving N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine.','2013-10-27','NSRP'),(36627,97173,'N-acetylmuramic acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine.','2013-10-27','NSRP'),(36628,97174,'1,6-anhydro-N-acetyl-beta-muramic acid metabolic process','P','The chemical reactions and pathways involving 1,6-anhydro-N-acetyl-beta-muramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid.','2013-10-27','NSRP'),(36629,97175,'1,6-anhydro-N-acetyl-beta-muramic acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 1,6-anhydro-N-acetylmuramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid.','2013-10-27','NSRP'),(36630,97176,'epoxide metabolic process','P','The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers.','2013-10-27','NSRP'),(36631,97177,'mitochondrial ribosome binding','F','Interacting selectively and non-covalently with any part of a mitochondrial ribosome, a ribosome found in the mitochondrion of a eukaryotic cell.','2013-10-27','NSRP'),(36632,97178,'ruffle assembly','P','The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.','2013-10-27','NSRP'),(36633,97179,'protease inhibitor complex','C','A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity.','2013-10-27','NSRP'),(36634,97180,'serine protease inhibitor complex','C','A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity.','2013-10-27','NSRP'),(36635,97181,'protein C inhibitor-coagulation factor V complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V.','2013-10-27','NSRP'),(36636,97182,'protein C inhibitor-coagulation factor Xa complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa.','2013-10-27','NSRP'),(36637,97183,'protein C inhibitor-coagulation factor XI complex','C','A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI.','2013-10-27','NSRP'),(36638,97184,'response to azide','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus.','2013-10-27','NSRP'),(36639,97185,'cellular response to azide','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus.','2013-10-27','NSRP'),(36640,97186,'amelogenesis','P','The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.','2013-10-27','NSRP'),(36641,97187,'dentinogenesis','P','The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin.','2013-10-27','NSRP'),(36642,97188,'dentin mineralization','P','The process in which calcium salts are deposited into the calcareous tooth structure known as dentin.','2013-10-27','NSRP'),(36643,97189,'apoptotic body','C','A fragment containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell\'s cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled.','2013-10-27','NSRP'),(36644,97190,'apoptotic signaling pathway','P','A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.','2013-10-27','NSRP'),(36645,97191,'extrinsic apoptotic signaling pathway','P','A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.','2013-10-27','NSRP'),(36646,97192,'extrinsic apoptotic signaling pathway in absence of ligand','P','A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.','2013-10-27','NSRP'),(36647,97193,'intrinsic apoptotic signaling pathway','P','A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).','2013-10-27','NSRP'),(36648,97194,'execution phase of apoptosis','P','A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The execution phase ends when the cell has died.','2013-10-27','NSRP'),(36649,97195,'pilomotor reflex','P','The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect.','2013-10-27','NSRP'),(36650,97196,'Shu complex','C','A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p.','2013-10-27','NSRP'),