(12009,18872,'arsonoacetate metabolic process','P','The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides.','2013-10-27','NSRP'),(12010,18873,'atrazine metabolic process','P','The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide.','2013-10-27','NSRP'),(12011,18874,'benzoate metabolic process','P','The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid.','2013-10-27','NSRP'),(12012,18875,'anaerobic benzoate metabolic process','P','The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen.','2013-10-27','NSRP'),(12013,18876,'benzonitrile metabolic process','P','The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin.','2013-10-27','NSRP'),(12014,18877,'beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process','P','The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health.','2013-10-27','NSRP'),(12015,18878,'aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process','P','The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen.','2013-10-27','NSRP'),(12016,18879,'biphenyl metabolic process','P','The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs).','2013-10-27','NSRP'),(12017,18880,'4-chlorobiphenyl metabolic process','P','The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation.','2013-10-27','NSRP'),(12018,18881,'bromoxynil metabolic process','P','The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants.','2013-10-27','NSRP'),(12019,18882,'(+)-camphor metabolic process','P','The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed.','2013-10-27','NSRP'),(12020,18883,'caprolactam metabolic process','P','The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation.','2013-10-27','NSRP'),(12021,18884,'carbazole metabolic process','P','The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen.','2013-10-27','NSRP'),(12022,18885,'carbon tetrachloride metabolic process','P','The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants.','2013-10-27','NSRP'),(12023,18886,'anaerobic carbon tetrachloride metabolic process','P','The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen.','2013-10-27','NSRP'),(12024,18887,'4-carboxy-4\'-sulfoazobenzene metabolic process','P','The chemical reactions and pathways involving 4-carboxy-4\'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid.','2013-10-27','NSRP'),(12025,18888,'3-chloroacrylic acid metabolic process','P','The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid.','2013-10-27','NSRP'),(12026,18889,'2-chloro-N-isopropylacetanilide metabolic process','P','The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants.','2013-10-27','NSRP'),(12027,18890,'cyanamide metabolic process','P','The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism.','2013-10-27','NSRP'),(12028,18891,'cyclohexanol metabolic process','P','The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent.','2013-10-27','NSRP'),(12029,18892,'cyclohexylsulfamate metabolic process','P','The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide.','2013-10-27','NSRP'),(12030,18893,'dibenzofuran metabolic process','P','The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals.','2013-10-27','NSRP'),(12031,18894,'dibenzo-p-dioxin metabolic process','P','The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern.','2013-10-27','NSRP'),(12032,18895,'dibenzothiophene metabolic process','P','The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion.','2013-10-27','NSRP'),(12033,18896,'dibenzothiophene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond.','2013-10-27','NSRP'),(12034,18897,'dibenzothiophene desulfurization','P','The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond.','2013-10-27','NSRP'),(12035,18898,'2,4-dichlorobenzoate metabolic process','P','The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs).','2013-10-27','NSRP'),(12036,18899,'1,2-dichloroethane metabolic process','P','The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride.','2013-10-27','NSRP'),(12037,18900,'dichloromethane metabolic process','P','The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover.','2013-10-27','NSRP'),(12038,18901,'2,4-dichlorophenoxyacetic acid metabolic process','P','The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds.','2013-10-27','NSRP'),(12039,18902,'1,3-dichloro-2-propanol metabolic process','P','The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers.','2013-10-27','NSRP'),(12040,18903,'1,3-dichloropropene metabolic process','P','The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes.','2013-10-27','NSRP'),(12041,18904,'ether metabolic process','P','The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds.','2013-10-27','NSRP'),(12042,18905,'dimethyl ether metabolic process','P','The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications.','2013-10-27','NSRP'),(12043,18906,'methyl tert-butyl ether metabolic process','P','The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent.','2013-10-27','NSRP'),(12044,18907,'dimethyl sulfoxide metabolic process','P','The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing.','2013-10-27','NSRP'),(12045,18908,'organosulfide cycle','P','A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle.','2013-10-27','NSRP'),(12046,18909,'dodecyl sulfate metabolic process','P','The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants.','2013-10-27','NSRP'),(12047,18910,'benzene metabolic process','P','The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation.','2013-10-27','NSRP'),(12048,18911,'1,2,4-trichlorobenzene metabolic process','P','The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides.','2013-10-27','NSRP'),(12049,18912,'1,4-dichlorobenzene metabolic process','P','The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs.','2013-10-27','NSRP'),(12050,18913,'anaerobic ethylbenzene metabolic process','P','The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen.','2013-10-27','NSRP'),(12051,18914,'chlorobenzene metabolic process','P','The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone.','2013-10-27','NSRP'),(12052,18915,'ethylbenzene metabolic process','P','The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels.','2013-10-27','NSRP'),(12053,18916,'nitrobenzene metabolic process','P','The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline.','2013-10-27','NSRP'),(12054,18917,'fluorene metabolic process','P','The chemical reactions and pathways involving fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents.','2013-10-27','NSRP'),(12055,18918,'gallate metabolic process','P','The chemical reactions and pathways involving gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). The esters and polyesters are widely distributed in angiosperms.','2013-10-27','NSRP'),(12056,18919,'gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process','P','The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health.','2013-10-27','NSRP'),(12057,18920,'glyphosate metabolic process','P','The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond.','2013-10-27','NSRP'),(12058,18921,'3-hydroxybenzyl alcohol metabolic process','P','The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum.','2013-10-27','NSRP'),(12059,18922,'iprodione metabolic process','P','The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium).','2013-10-27','NSRP'),(12060,18923,'limonene metabolic process','P','The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene.','2013-10-27','NSRP'),(12061,18924,'mandelate metabolic process','P','The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic.','2013-10-27','NSRP'),(12062,18925,'m-cresol metabolic process','P','The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes.','2013-10-27','NSRP'),(12063,18926,'methanesulfonic acid metabolic process','P','The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide.','2013-10-27','NSRP'),(12064,18927,'methionine and threonine metabolic process','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12065,18928,'methyl ethyl ketone metabolic process','P','The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints.','2013-10-27','NSRP'),(12066,18929,'methyl fluoride metabolic process','P','The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils.','2013-10-27','NSRP'),(12067,18930,'3-methylquinoline metabolic process','P','The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring.','2013-10-27','NSRP'),(12068,18931,'naphthalene metabolic process','P','The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide.','2013-10-27','NSRP'),(12069,18933,'nicotine metabolic process','P','The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine.','2013-10-27','NSRP'),(12070,18934,'nitrilotriacetate metabolic process','P','The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment.','2013-10-27','NSRP'),(12071,18935,'aerobic nitrilotriacetate metabolic process','P','The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen.','2013-10-27','NSRP'),(12072,18936,'anaerobic nitrilotriacetate metabolic process','P','The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen.','2013-10-27','NSRP'),(12073,18937,'nitroglycerin metabolic process','P','The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates.','2013-10-27','NSRP'),(12074,18938,'2-nitropropane metabolic process','P','The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol.','2013-10-27','NSRP'),(12075,18939,'n-octane metabolic process','P','The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System.','2013-10-27','NSRP'),(12076,18940,'orcinol metabolic process','P','The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants.','2013-10-27','NSRP'),(12077,18941,'organomercury metabolic process','P','The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom.','2013-10-27','NSRP'),(12078,18942,'organometal metabolic process','P','The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms.','2013-10-27','NSRP'),(12079,18943,'organotin metabolic process','P','The chemical reactions and pathways involving organotin, an organic compound containing a tin atom.','2013-10-27','NSRP'),(12080,18944,'tri-n-butyltin metabolic process','P','The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms.','2013-10-27','NSRP'),(12081,18945,'organosilicon metabolic process','P','The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon.','2013-10-27','NSRP'),(12082,18946,'aerobic organosilicon metabolic process','P','The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen.','2013-10-27','NSRP'),(12083,18947,'anaerobic organosilicon metabolic process','P','The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen.','2013-10-27','NSRP'),(12084,18948,'xylene metabolic process','P','The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene.','2013-10-27','NSRP'),(12085,18949,'m-xylene metabolic process','P','The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon.','2013-10-27','NSRP'),(12086,18950,'o-xylene metabolic process','P','The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon.','2013-10-27','NSRP'),(12087,18951,'p-xylene metabolic process','P','The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon.','2013-10-27','NSRP'),(12088,18952,'parathion metabolic process','P','The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.','2013-10-27','NSRP'),(12089,18953,'p-cymene metabolic process','P','The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants.','2013-10-27','NSRP'),(12090,18954,'pentaerythritol tetranitrate metabolic process','P','The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator.','2013-10-27','NSRP'),(12091,18955,'phenanthrene metabolic process','P','The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish.','2013-10-27','NSRP'),(12092,18956,'phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene','P','The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite.','2013-10-27','NSRP'),(12093,18957,'phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene','P','The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite.','2013-10-27','NSRP'),(12094,18958,'phenol-containing compound metabolic process','P','The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.','2013-10-27','NSRP'),(12095,18959,'aerobic phenol-containing compound metabolic process','P','The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen.','2013-10-27','NSRP'),(12096,18960,'4-nitrophenol metabolic process','P','The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion.','2013-10-27','NSRP'),(12097,18961,'pentachlorophenol metabolic process','P','The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms.','2013-10-27','NSRP'),(12098,18962,'3-phenylpropionate metabolic process','P','The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins.','2013-10-27','NSRP'),(12099,18963,'phthalate metabolic process','P','The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses.','2013-10-27','NSRP'),(12100,18964,'propylene metabolic process','P','The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals.','2013-10-27','NSRP'),(12101,18965,'s-triazine compound metabolic process','P','The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms.','2013-10-27','NSRP'),(12102,18966,'styrene metabolic process','P','The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen.','2013-10-27','NSRP'),(12103,18967,'tetrachloroethylene metabolic process','P','The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent.','2013-10-27','NSRP'),(12104,18968,'tetrahydrofuran metabolic process','P','The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems.','2013-10-27','NSRP'),(12105,18969,'thiocyanate metabolic process','P','The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries.','2013-10-27','NSRP'),(12106,18970,'toluene metabolic process','P','The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications.','2013-10-27','NSRP'),(12107,18971,'anaerobic toluene metabolic process','P','The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen.','2013-10-27','NSRP'),(12108,18972,'toluene-4-sulfonate metabolic process','P','The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water.','2013-10-27','NSRP'),(12109,18973,'trinitrotoluene metabolic process','P','The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene.','2013-10-27','NSRP'),(12110,18974,'2,4,6-trinitrotoluene metabolic process','P','The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives.','2013-10-27','NSRP'),(12111,18975,'anaerobic 2,4,6-trinitrotoluene metabolic process','P','The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen.','2013-10-27','NSRP'),(12112,18976,'1,2,3-tribromopropane metabolic process','P','The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture.','2013-10-27','NSRP'),(12113,18977,'1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process','P','The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide.','2013-10-27','NSRP'),(12114,18978,'anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process','P','The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen.','2013-10-27','NSRP'),(12115,18979,'trichloroethylene metabolic process','P','The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent.','2013-10-27','NSRP'),(12116,18980,'2,4,5-trichlorophenoxyacetic acid metabolic process','P','The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns.','2013-10-27','NSRP'),(12117,18981,'triethanolamine metabolic process','P','The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent.','2013-10-27','NSRP'),(12118,18982,'vanillin metabolic process','P','The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin.','2013-10-27','NSRP'),(12119,18983,'Z-phenylacetaldoxime metabolic process','P','The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants.','2013-10-27','NSRP'),(12120,18984,'naphthalenesulfonate metabolic process','P','The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene.','2013-10-27','NSRP'),(12121,18985,'pronuclear envelope synthesis','P','Synthesis and ordering of the envelope of pronuclei.','2013-10-27','NSRP'),(12122,18988,'molting cycle, protein-based cuticle','P','OBSOLETE. The periodic shedding of part or all of a protein-based cuticle, which is then replaced by a new protein-based cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss.','2013-10-27','NSRP'),(12123,18989,'apolysis','P','The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells.','2013-10-27','NSRP'),(12124,18990,'ecdysis, chitin-based cuticle','P','The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(12125,18991,'oviposition','P','The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.','2013-10-27','NSRP'),(12126,18992,'germ-line sex determination','P','The determination of sex and sexual phenotype in an organism\'s germ line.','2013-10-27','NSRP'),(12127,18993,'somatic sex determination','P','The determination of sex and sexual phenotypes in an organism\'s soma.','2013-10-27','NSRP'),(12128,18995,'host','C','Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection.','2013-10-27','NSRP'),(12129,18996,'molting cycle, collagen and cuticulin-based cuticle','P','The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans.','2013-10-27','NSRP'),(12130,18997,'electron transfer carrier','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12131,18998,'metaxin','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12132,19000,'endonuclease G activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12133,19001,'guanyl nucleotide binding','F','Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate.','2013-10-27','NSRP'),(12134,19002,'GMP binding','F','Interacting selectively and non-covalently with GMP, guanosine monophosphate.','2013-10-27','NSRP'),(12135,19003,'GDP binding','F','Interacting selectively and non-covalently with GDP, guanosine 5\'-diphosphate.','2013-10-27','NSRP'),(12136,19005,'SCF ubiquitin ligase complex','C','A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).','2013-10-27','NSRP'),(12137,19008,'molybdopterin synthase complex','C','A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits.','2013-10-27','NSRP'),(12138,19010,'farnesoic acid O-methyltransferase activity','F','Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(12139,19011,'DNA replication accessory factor','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12140,19012,'virion','C','The complete fully infectious extracellular virus particle.','2013-10-27','NSRP'),(12141,19013,'viral nucleocapsid','C','The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle.','2013-10-27','NSRP'),(12142,19015,'viral genome','C','The whole of the genetic information of a virus, contained as either DNA or RNA.','2013-10-27','NSRP'),(12143,19016,'non-segmented viral genome','C','A viral genome that consists of one continuous nucleic acid molecule.','2013-10-27','NSRP'),(12144,19017,'segmented viral genome','C','A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion.','2013-10-27','NSRP'),(12145,19018,'bipartite viral genome','C','A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion.','2013-10-27','NSRP'),(12146,19019,'tripartite viral genome','C','A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion.','2013-10-27','NSRP'),(12147,19020,'multipartite viral genome','C','A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion.','2013-10-27','NSRP'),(12148,19021,'DNA viral genome','C','A viral genome composed of deoxyribonucleic acid.','2013-10-27','NSRP'),(12149,19022,'RNA viral genome','C','A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked.','2013-10-27','NSRP'),(12150,19023,'dsRNA viral genome','C','A viral genome composed of double stranded RNA.','2013-10-27','NSRP'),(12151,19024,'ssRNA viral genome','C','A viral genome composed of single stranded RNA of either positive or negative sense.','2013-10-27','NSRP'),(12152,19025,'positive sense viral genome','C','A single stranded RNA genome with the same nucleotide polarity as mRNA.','2013-10-27','NSRP'),(12153,19026,'negative sense viral genome','C','A single stranded RNA genome with the opposite nucleotide polarity as mRNA.','2013-10-27','NSRP'),(12154,19027,'ambisense viral genome','C','A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule.','2013-10-27','NSRP'),(12155,19028,'viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres.','2013-10-27','NSRP'),(12156,19029,'helical viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure.','2013-10-27','NSRP'),(12157,19030,'icosahedral viral capsid','C','The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. Tobacco satellite necrosis virus has such a capsid structure.','2013-10-27','NSRP'),(12158,19031,'viral envelope','C','The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins.','2013-10-27','NSRP'),(12159,19032,'viral glycoprotein','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12160,19033,'viral tegument','C','A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically.','2013-10-27','NSRP'),(12161,19034,'viral replication complex','C','Specific locations and structures in the virus infected cell involved in replicating the viral genome.','2013-10-27','NSRP'),(12162,19035,'viral integration complex','C','A nucleoprotein complex containing viral genetic material and associated viral and host proteins, which is capable of inserting a viral genome into a host genome.','2013-10-27','NSRP'),(12163,19036,'viral transcriptional complex','C','Specific locations and structures in the virus infected cell involved in transcribing the viral genome.','2013-10-27','NSRP'),(12164,19037,'viral assembly intermediate','C','Specific locations and structures in the virus infected cell involved in assembling new virions.','2013-10-27','NSRP'),(12165,19038,'provirus','C','The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle.','2013-10-27','NSRP'),(12166,19039,'viral-cell fusion molecule activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12167,19040,'viral host shutoff protein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12168,19042,'viral latency','P','The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate.','2013-10-27','NSRP'),(12169,19043,'establishment of viral latency','P','A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects.','2013-10-27','NSRP'),(12170,19044,'maintenance of viral latency','P','The perpetuation of a latent state, generally by repressing the viruses own lytic genes expression and ensuring expression of viral genes which function to keep the viral genome from being detected by the host defense mechanisms.','2013-10-27','NSRP'),(12171,19045,'latent virus replication','P','Any process required for latent viral replication in a cell.','2013-10-27','NSRP'),(12172,19046,'release from viral latency','P','The process by which a virus switches from latency and begins to replicate. It may be effected by various endogenous and exogenous stimuli, including B-cell lipopolysaccharides, glucocorticoid hormones, halogenated pyrimidines, ionizing radiation, ultraviolet light, various chemicals and super-infecting viruses.','2013-10-27','NSRP'),(12173,19047,'provirus integration','P','The molecular events that lead to the integration of a viral genome into the host genome.','2012-03-14','NSRP'),(12174,19048,'modulation by virus of host morphology or physiology','P','The process in which a virus effects a change in the structure or processes of its host organism.','2013-10-27','NSRP'),(12175,19049,'evasion or tolerance of host defenses by virus','P','Any process, either active or passive, by which a virus avoids or tolerates the effects of its host organism\'s defense(s). Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(12176,19050,'suppression by virus of host apoptotic process','P','Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication.','2013-10-27','NSRP'),(12177,19051,'induction by virus of host apoptotic process','P','The set of viral processes that induce an apoptotic process in infected host cells, facilitating release and spread of progeny virions.','2013-10-27','NSRP'),(12178,19052,'suppression by virus of host intracellular antiviral response','P','Any viral process that results in the inhibition of intracellular (innate immune response) antiviral mechanisms, thereby facilitating viral replication.','2013-10-27','NSRP'),(12179,19053,'suppression by virus of host extracellular antiviral response','P','Any viral process that results in the inhibition of extracellular (adaptive immune response) antiviral mechanisms, thereby facilitating viral replication.','2013-10-27','NSRP'),(12180,19054,'modulation by virus of host process','P','The process in which a virus effects a change in the processes and activities of its host organism.','2013-10-27','NSRP'),(12181,19055,'modification by virus of host cell cycle regulation','P','Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication.','2013-10-27','NSRP'),(12182,19056,'modulation by virus of host transcription','P','The modulation by viral gene products of host RNA polymerase II facilitated transcription.','2013-10-27','NSRP'),(12183,19057,'modulation by virus of host translation','P','Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA.','2013-10-27','NSRP'),(12184,19058,'viral life cycle','P','A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.','2013-10-27','NSRP'),(12185,19059,'initiation of viral infection','P','OBSOLETE. The set of processes involved in the start of virus infection of cells.','2013-10-27','NSRP'),(12186,19060,'intracellular transport of viral proteins in host cell','P','The directed movement of viral proteins within the host cell.','2013-10-27','NSRP'),(12187,19061,'uncoating of virus','P','The process by which an incoming virion is disassembled in the host cell to release a replication-competent viral genome.','2013-10-27','NSRP'),(12188,19062,'viral attachment to host cell','P','The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection.','2013-10-27','NSRP'),(12189,19063,'virion penetration into host cell','P','Any process required for the introduction of virus particles into the cell.','2012-03-14','NSRP'),(12190,19064,'fusion of virus membrane with host plasma membrane','P','Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm.','2013-10-27','NSRP'),(12191,19065,'receptor-mediated endocytosis of virus by host cell','P','Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell.','2013-10-27','NSRP'),(12192,19066,'translocation of virus into host cell','P','OBSOLETE. The translocation of an entire virus particle across the host cell plasma membrane.','2013-10-27','NSRP'),(12193,19067,'viral assembly, maturation, egress, and release','P','Any process involved in the assembly, maturation, egress, and release of progeny virions.','2013-09-22','NSRP'),(12194,19068,'virion assembly','P','A late phase of viral replication during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed.','2013-10-27','NSRP'),(12195,19069,'viral capsid assembly','P','The assembly of a virus capsid from its protein subunits.','2013-10-27','NSRP'),(12196,19070,'viral genome maturation','P','Any viral process that occurs on newly synthesized viral genomes.','2013-10-27','NSRP'),(12197,19071,'viral DNA cleavage involved in viral genome maturation','P','The cleavage of viral DNA into singular functional units.','2013-10-27','NSRP'),(12198,19072,'viral genome packaging','P','The encapsulation of the viral genome within the capsid.','2013-10-27','NSRP'),(12199,19073,'viral DNA genome packaging','P','The packing of viral DNA into a capsid.','2013-10-27','NSRP'),(12200,19074,'viral RNA genome packaging','P','The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid.','2013-10-27','NSRP'),(12201,19075,'virus maturation','P','The assembly of the component viral parts into an infectious virion.','2013-10-27','NSRP'),(12202,19076,'viral release from host cell','P','The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane.','2013-10-27','NSRP'),(12203,19077,'lytic viral release','P','Disruption of host cellular membranes, leading to cell death and the release of cytoplasmic compounds, including cytoplasmic viral particles, into the extracellular space.','2013-09-22','NSRP'),(12204,19078,'lytic viral budding','P','OBSOLETE. A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment.','2013-10-27','NSRP'),(12205,19079,'viral genome replication','P','Any process involved directly in viral genome replication, including viral nucleotide metabolism.','2013-10-27','NSRP'),(12206,19080,'viral gene expression','P','A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation.','2013-10-27','NSRP'),(12207,19081,'viral translation','P','A process by which viral mRNA is translated into viral protein, using the host cellular machinery.','2013-10-27','NSRP'),(12208,19082,'viral protein processing','P','Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein.','2013-10-27','NSRP'),(12209,19083,'viral transcription','P','The process by which a viral genome is transcribed into messenger RNA (mRNA) within the host cell.','2013-10-27','NSRP'),(12210,19084,'(delayed) early viral mRNA transcription','P','The second round of viral gene transcription; most genes transcribed in this round are necessary for genome replication.','2013-10-27','NSRP'),(12211,19085,'immediate early viral mRNA transcription','P','The transcriptional period of the earliest expressed viral genes, mainly encoding transcriptional regulators.','2013-10-27','NSRP'),(12212,19086,'late viral mRNA transcription','P','The last group of viral genes to be transcribed during the viral life cycle; genes consist mainly of those encoding structural proteins.','2013-10-27','NSRP'),(12213,19087,'transformation of host cell by virus','P','Any virus-induced change in the morphological, biochemical, or growth parameters of a cell.','2013-10-27','NSRP'),(12214,19088,'immortalization of host cell by virus','P','A virus-induced cellular transformation arising in immortalized cells, or cells capable of indefinite replication, due to their ability to produce their own telomerase.','2013-10-27','NSRP'),(12215,19089,'transmission of virus','P','The transfer of virions in order to create new infection.','2013-10-27','NSRP'),(12216,19090,'mitochondrial rRNA export from mitochondrion','P','The directed movement of mitochondrial rRNA out of a mitochondrion.','2013-10-27','NSRP'),(12217,19091,'mitochondrial lrRNA export from mitochondrion','P','The directed movement of mitochondrial lrRNA out of a mitochondrion.','2013-10-27','NSRP'),(12218,19092,'mitochondrial srRNA export from mitochondrion','P','The directed movement of mitochondrial srRNA out of a mitochondrion.','2013-10-27','NSRP'),(12219,19093,'mitochondrial RNA localization','P','Any process in which mitochondrial RNA is transported to, or maintained in, a specific location.','2013-10-27','NSRP'),(12220,19094,'pole plasm mRNA localization','P','Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(12221,19095,'pole plasm mitochondrial rRNA localization','P','Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(12222,19096,'pole plasm mitochondrial lrRNA localization','P','Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(12223,19097,'pole plasm mitochondrial srRNA localization','P','Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(12224,19098,'reproductive behavior','P','The specific behavior of an organism that is associated with reproduction.','2013-10-27','NSRP'),(12225,19099,'female germ-line sex determination','P','The determination of sex and sexual phenotype in a female organism\'s germ line.','2013-10-27','NSRP'),(12226,19100,'male germ-line sex determination','P','The determination of sex and sexual phenotype in a male organism\'s germ line.','2013-10-27','NSRP'),(12227,19101,'female somatic sex determination','P','The determination of sex and sexual phenotypes in a female organism\'s soma.','2013-10-27','NSRP'),(12228,19102,'male somatic sex determination','P','The determination of sex and sexual phenotypes in a male organism\'s soma.','2013-10-27','NSRP'),(12229,19103,'pyrimidine nucleotide binding','F','Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate.','2013-10-27','NSRP'),(12230,19104,'DNA N-glycosylase activity','F','Catalysis of the removal of damaged bases by cleaving the N-C1\' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.','2013-10-27','NSRP'),(12231,19105,'N-palmitoyltransferase activity','F','Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule.','2013-10-27','NSRP'),(12232,19107,'myristoyltransferase activity','F','Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule.','2013-10-27','NSRP'),(12233,19108,'aryl-aldehyde dehydrogenase (NAD) activity','F','Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+.','2013-10-27','NSRP'),(12234,19111,'phenanthrol sulfotransferase activity','F','Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate.','2013-10-27','NSRP'),(12235,19112,'phenanthrol glycosyltransferase activity','F','Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O.','2013-10-27','NSRP'),(12236,19113,'limonene monooxygenase activity','F','Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene.','2013-10-27','NSRP'),(12237,19114,'catechol dioxygenase activity','F','Catalysis of the reaction: catechol + O2 = a muconate.','2013-10-27','NSRP'),(12238,19115,'benzaldehyde dehydrogenase activity','F','Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+.','2013-10-27','NSRP'),(12239,19116,'hydroxy-nicotine oxidase activity','F','Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide.','2013-10-27','NSRP'),(12240,19117,'dihydroxyfluorene dioxygenase activity','F','Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid.','2013-10-27','NSRP'),(12241,19118,'phenanthrene-epoxide hydrolase activity','F','Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene.','2013-10-27','NSRP'),(12242,19119,'phenanthrene-9,10-epoxide hydrolase activity','F','Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene.','2013-10-27','NSRP'),(12243,19120,'hydrolase activity, acting on acid halide bonds, in C-halide compounds','F','Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage.','2013-10-27','NSRP'),(12244,19121,'peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine','P','The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan.','2013-10-27','NSRP'),(12245,19122,'peptidyl-D-alanine racemization','P','The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine.','2013-10-27','NSRP'),(12246,19123,'peptidyl-methionine racemization','P','The racemization of peptidyl-methionine.','2013-10-27','NSRP'),(12247,19124,'peptidyl-isoleucine racemization','P','The racemization of peptidyl-isoleucine.','2013-10-27','NSRP'),(12248,19125,'peptidyl-phenylalanine racemization','P','The racemization of peptidyl-phenylalanine.','2013-10-27','NSRP'),(12249,19126,'peptidyl-serine racemization','P','The racemization of peptidyl-serine.','2013-10-27','NSRP'),(12250,19128,'peptidyl-tryptophan racemization','P','The racemization of peptidyl-tryptophan.','2013-10-27','NSRP'),(12251,19129,'peptidyl-leucine racemization','P','The racemization of peptidyl-leucine.','2013-10-27','NSRP'),(12252,19131,'tripeptidyl-peptidase I activity','F','OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH.','2013-10-27','NSRP'),(12253,19132,'C-terminal processing peptidase activity','F','OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala.','2013-10-27','NSRP'),(12254,19133,'choline monooxygenase activity','F','Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O.','2013-10-27','NSRP'),(12255,19134,'glucosamine-1-phosphate N-acetyltransferase activity','F','Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+).','2013-10-27','NSRP'),(12256,19135,'deoxyhypusine monooxygenase activity','F','Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O.','2013-10-27','NSRP'),(12257,19136,'deoxynucleoside kinase activity','F','Catalysis of the reaction: ATP + 2\'-deoxynucleoside = ADP + 2\'-deoxynucleoside 5\'-phosphate.','2013-10-27','NSRP'),(12258,19137,'thioglucosidase activity','F','Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar.','2013-10-27','NSRP'),(12259,19139,'cytokinin dehydrogenase activity','F','Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor.','2013-10-27','NSRP'),(12260,19140,'inositol 3-kinase activity','F','Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate.','2013-10-27','NSRP'),(12261,19141,'2-dehydropantolactone reductase (B-specific) activity','F','Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+.','2013-10-27','NSRP'),(12262,19142,'2-hydroxyglutarate synthase activity','F','Catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+).','2013-10-27','NSRP'),(12263,19143,'3-deoxy-manno-octulosonate-8-phosphatase activity','F','Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate.','2013-10-27','NSRP'),(12264,19144,'ADP-sugar diphosphatase activity','F','Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate.','2013-10-27','NSRP'),(12265,19145,'aminobutyraldehyde dehydrogenase activity','F','Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+.','2013-10-27','NSRP'),(12266,19146,'arabinose-5-phosphate isomerase activity','F','Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+).','2013-10-27','NSRP'),(12267,19147,'(R)-aminopropanol dehydrogenase activity','F','Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH.','2013-10-27','NSRP'),(12268,19148,'D-cysteine desulfhydrase activity','F','Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate.','2013-10-27','NSRP'),(12269,19149,'3-chloro-D-alanine dehydrochlorinase activity','F','Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3.','2013-10-27','NSRP'),(12270,19150,'D-ribulokinase activity','F','Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate.','2013-10-27','NSRP'),(12271,19151,'galactose 1-dehydrogenase activity','F','Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+.','2013-10-27','NSRP'),(12272,19152,'acetoin dehydrogenase activity','F','Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+.','2013-10-27','NSRP'),(12273,19153,'protein-disulfide reductase (glutathione) activity','F','Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol.','2013-10-27','NSRP'),(12274,19154,'glycolate dehydrogenase activity','F','Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate.','2013-10-27','NSRP'),(12275,19155,'3-(imidazol-5-yl)lactate dehydrogenase activity','F','Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+.','2013-10-27','NSRP'),(12276,19156,'isoamylase activity','F','Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins.','2013-10-27','NSRP'),(12277,19157,'malate oxidase activity','F','Catalysis of the reaction: (S)-malate + O(2) = H(2)O(2) + oxaloacetate.','2013-10-27','NSRP'),(12278,19158,'mannokinase activity','F','Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate.','2013-10-27','NSRP'),(12279,19159,'nicotinamide-nucleotide amidase activity','F','Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3.','2013-10-27','NSRP'),(12280,19160,'NMN nucleosidase activity','F','Catalysis of the reaction: H(2)O + nicotinamide mononucleotide = D-ribose 5-phosphate + H(+) + nicotinamide.','2013-10-27','NSRP'),(12281,19161,'diamine transaminase activity','F','Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate.','2013-10-27','NSRP'),(12282,19162,'pyridoxamine-oxaloacetate transaminase activity','F','Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal.','2013-10-27','NSRP'),(12283,19163,'pyridoxamine-phosphate transaminase activity','F','Catalysis of the reaction: pyridoxamine 5\'-phosphate + 2-oxoglutarate = pyridoxal 5\'-phosphate + D-glutamate.','2013-10-27','NSRP'),(12284,19164,'pyruvate synthase activity','F','Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+.','2013-10-27','NSRP'),(12285,19165,'thiamine kinase activity','F','Catalysis of the reaction: ATP + thiamine = ADP + 2 H(+) + thiamine phosphate.','2013-10-27','NSRP'),(12286,19166,'trans-2-enoyl-CoA reductase (NADPH) activity','F','Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+.','2013-10-27','NSRP'),(12287,19168,'2-octaprenylphenol hydroxylase activity','F','Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O.','2013-10-27','NSRP'),(12288,19170,'methylglyoxal reductase (NADH-dependent) activity','F','Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+.','2013-10-27','NSRP'),(12289,19171,'3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity','F','Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein].','2013-10-27','NSRP'),(12290,19172,'glyoxalase III activity','F','Catalysis of the reaction: methylglyoxal + H2O = D-lactate.','2013-10-27','NSRP'),(12291,19174,'tetrahydrothiophene 1-oxide reductase activity','F','Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor.','2013-10-27','NSRP'),(12292,19176,'dihydroneopterin monophosphate phosphatase activity','F','Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate.','2013-10-27','NSRP'),(12293,19177,'dihydroneopterin triphosphate pyrophosphohydrolase activity','F','Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate.','2013-10-27','NSRP'),(12294,19178,'NADP phosphatase activity','F','Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate.','2013-10-27','NSRP'),(12295,19179,'dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity','F','Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate.','2013-10-27','NSRP'),(12296,19180,'dTDP-4-amino-4,6-dideoxygalactose transaminase activity','F','Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose.','2013-10-27','NSRP'),(12297,19181,'halohydrin hydrogen-halide-lyase activity','F','Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide.','2013-10-27','NSRP'),(12298,19182,'histamine-gated chloride channel activity','F','Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(12299,19183,'histamine-gated chloride channel complex','C','A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(12300,19184,'nonribosomal peptide biosynthetic process','P','The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione.','2013-10-27','NSRP'),(12301,19185,'snRNA-activating protein complex','C','A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters.','2013-10-27','NSRP'),(12302,19186,'acyl-CoA N-acyltransferase activity','F','Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule.','2013-10-27','NSRP'),(12303,19187,'beta-1,4-mannosyltransferase activity','F','Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage.','2013-10-27','NSRP'),(12304,19191,'cellobiose transmembrane transporter activity','F','Catalysis of the transfer of cellobiose from one side of the membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose.','2013-10-27','NSRP'),(12305,19194,'sorbose transmembrane transporter activity','F','Catalysis of the transfer of sorbose from one side of the membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid.','2013-10-27','NSRP'),(12306,19196,'galactosamine transmembrane transporter activity','F','Catalysis of the transfer of galactosamine from one side of the membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative.','2013-10-27','NSRP'),(12307,19197,'phosphoenolpyruvate-dependent sugar phosphotransferase complex','C','Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system).','2013-10-27','NSRP'),(12308,19198,'transmembrane receptor protein phosphatase activity','F','Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate.','2013-10-27','NSRP'),(12309,19199,'transmembrane receptor protein kinase activity','F','Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP.','2013-10-27','NSRP'),(12310,19200,'carbohydrate kinase activity','F','Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule.','2013-10-27','NSRP'),(12311,19201,'nucleotide kinase activity','F','Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate.','2013-10-27','NSRP'),(12312,19202,'amino acid kinase activity','F','Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate.','2013-10-27','NSRP'),(12313,19203,'carbohydrate phosphatase activity','F','Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate.','2013-10-27','NSRP'),(12314,19204,'nucleotide phosphatase activity','F','OBSOLETE: Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate.','2013-10-27','NSRP'),(12315,19205,'nucleobase-containing compound kinase activity','F','Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate.','2013-10-27','NSRP'),(12316,19206,'nucleoside kinase activity','F','Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate.','2013-10-27','NSRP'),(12317,19207,'kinase regulator activity','F','Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.','2013-10-27','NSRP'),(12318,19208,'phosphatase regulator activity','F','Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.','2013-10-27','NSRP'),(12319,19209,'kinase activator activity','F','Increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.','2013-10-27','NSRP'),(12320,19210,'kinase inhibitor activity','F','Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.','2013-10-27','NSRP'),(12321,19211,'phosphatase activator activity','F','Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.','2013-10-27','NSRP'),(12322,19212,'phosphatase inhibitor activity','F','Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule.','2013-10-27','NSRP'),(12323,19213,'deacetylase activity','F','Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.','2013-10-27','NSRP'),(12324,19214,'surfactant activity','F','OBSOLETE. The action of reducing the surface tension of a liquid.','2013-10-27','NSRP'),(12325,19215,'intermediate filament binding','F','Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space.','2013-10-27','NSRP'),(12326,19216,'regulation of lipid metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.','2013-10-27','NSRP'),(12327,19217,'regulation of fatty acid metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.','2013-10-27','NSRP'),(12328,19218,'regulation of steroid metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids.','2013-10-27','NSRP'),(12329,19219,'regulation of nucleobase-containing compound metabolic process','P','Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids.','2013-10-27','NSRP'),(12330,19220,'regulation of phosphate metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates.','2013-10-27','NSRP'),(12331,19221,'cytokine-mediated signaling pathway','P','A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(12332,19222,'regulation of metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.','2013-10-27','NSRP'),(12333,19226,'transmission of nerve impulse','P','The neurological system process in which a signal is transmitted through the nervous system by synaptic transmission and the sequential electrochemical polarization and depolarization that travels across the membrane of a nerve cell (neuron) in response to stimulation.','2013-10-27','NSRP'),(12334,19227,'neuronal action potential propagation','P','A neurological process that causes the sequential depolarization of a neuron\'s cell membrane along an axon.','2013-10-27','NSRP'),(12335,19228,'regulation of action potential in neuron','P','The process that modulates the membrane potential involved in the propagation of a signal in a neuron.','2013-10-27','NSRP'),(12336,19229,'regulation of vasoconstriction','P','Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels.','2013-10-27','NSRP'),(12337,19230,'proprioception','P','The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors.','2013-10-27','NSRP'),(12338,19231,'perception of static position','P','The perception of the orientation of different parts of the body with respect to one another.','2013-10-27','NSRP'),(12339,19232,'perception of rate of movement','P','The series of events by which an organism senses the speed and direction of movement of the body and its parts.','2013-10-27','NSRP'),(12340,19233,'sensory perception of pain','P','The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process.','2013-10-27','NSRP'),(12341,19234,'sensory perception of fast pain','P','The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds.','2013-10-27','NSRP'),(12342,19235,'sensory perception of slow pain','P','The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction.','2013-10-27','NSRP'),(12343,19236,'response to pheromone','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus.','2013-10-27','NSRP'),(12344,19237,'centromeric DNA binding','F','Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis.','2013-10-27','NSRP'),(12345,19238,'cyclohydrolase activity','F','Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring.','2013-10-27','NSRP'),(12346,19239,'deaminase activity','F','Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3).','2013-10-27','NSRP'),(12347,19240,'citrulline biosynthetic process','P','The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.','2013-10-27','NSRP'),(12348,19241,'citrulline catabolic process','P','The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.','2013-10-27','NSRP'),(12349,19242,'methylglyoxal biosynthetic process','P','The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.','2013-10-27','NSRP'),(12350,19243,'methylglyoxal catabolic process to D-lactate','P','The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.','2013-10-27','NSRP'),(12351,19244,'lactate biosynthetic process from pyruvate','P','The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate.','2013-10-27','NSRP'),(12352,19245,'D(-)-lactate biosynthetic process from pyruvate','P','The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate.','2013-10-27','NSRP'),(12353,19246,'L(+)-lactate biosynthetic process from pyruvate','P','The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate.','2013-10-27','NSRP'),(12354,19247,'lactate racemization','P','Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture.','2013-10-27','NSRP'),(12355,19248,'D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde','P','The chemical reactions and pathways resulting in the formation of D-lactate from other compounds, including methylglyoxal, via the intermediate (R)-lactaldehyde.','2013-10-27','NSRP'),(12356,19249,'lactate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid.','2013-10-27','NSRP'),(12357,19250,'aerobic cobalamin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen.','2013-10-27','NSRP'),(12358,19251,'anaerobic cobalamin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen.','2013-10-27','NSRP'),(12359,19252,'starch biosynthetic process','P','The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants.','2013-10-27','NSRP'),(12360,19253,'reductive pentose-phosphate cycle','P','The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate.','2013-10-27','NSRP'),(12361,19254,'carnitine metabolic process, CoA-linked','P','The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA.','2013-10-27','NSRP'),(12362,19255,'glucose 1-phosphate metabolic process','P','The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1.','2013-10-27','NSRP'),(12363,19256,'acrylonitrile catabolic process','P','The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers.','2013-10-27','NSRP'),(12364,19257,'4-nitrotoluene metabolic process','P','The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor.','2013-10-27','NSRP'),(12365,19258,'4-nitrotoluene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene.','2013-10-27','NSRP'),(12366,19260,'1,2-dichloroethane catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride.','2013-10-27','NSRP'),(12367,19261,'1,4-dichlorobenzene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring.','2013-10-27','NSRP'),(12368,19262,'N-acetylneuraminate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid.','2013-10-27','NSRP'),(12369,19263,'adamantanone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists.','2013-10-27','NSRP'),(12370,19264,'glycine biosynthetic process from serine','P','The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.','2013-10-27','NSRP'),(12371,19265,'glycine biosynthetic process, by transamination of glyoxylate','P','The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate.','2013-10-27','NSRP'),(12372,19266,'asparagine biosynthetic process from oxaloacetate','P','The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate.','2013-10-27','NSRP'),(12373,19267,'asparagine biosynthetic process from cysteine','P','The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine.','2013-10-27','NSRP'),(12374,19268,'glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)','P','OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+).','2013-10-27','NSRP'),(12375,19269,'glutamate biosynthetic process, using glutamate synthase (NADPH)','P','OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH).','2013-10-27','NSRP'),(12376,19270,'aerobactin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid.','2013-10-27','NSRP'),(12377,19271,'aerobactin transport','P','The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid.','2013-10-27','NSRP'),(12378,19272,'L-alanine biosynthetic process from pyruvate','P','The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate.','2013-10-27','NSRP'),(12379,19273,'L-alanine biosynthetic process via ornithine','P','The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine.','2013-10-27','NSRP'),(12380,19276,'UDP-N-acetylgalactosamine metabolic process','P','The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.','2013-10-27','NSRP'),(12381,19277,'UDP-N-acetylgalactosamine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.','2013-10-27','NSRP'),(12382,19278,'UDP-N-acetylgalactosamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate.','2013-10-27','NSRP'),(12383,19279,'L-methionine biosynthetic process from L-homoserine via cystathionine','P','The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine.','2013-10-27','NSRP'),(12384,19280,'L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine','P','The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine.','2013-10-27','NSRP'),(12385,19281,'L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine','P','The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine.','2013-10-27','NSRP'),(12386,19282,'L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine','P','The direct chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-acetyl-L-homoserine.','2012-03-14','NSRP'),(12387,19283,'L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine','P','The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine.','2013-10-27','NSRP'),(12388,19284,'L-methionine biosynthetic process from S-adenosylmethionine','P','The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including S-adenosylmethionine.','2013-10-27','NSRP'),(12389,19285,'glycine betaine biosynthetic process from choline','P','The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline.','2013-10-27','NSRP'),(12390,19286,'glycine betaine biosynthetic process from glycine','P','The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine.','2013-10-27','NSRP'),(12391,19287,'isopentenyl diphosphate biosynthetic process, mevalonate pathway','P','The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates.','2013-10-27','NSRP'),(12392,19288,'isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway','P','The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.','2013-10-27','NSRP'),(12393,19289,'rhizobactin 1021 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti.','2013-10-27','NSRP'),(12394,19290,'siderophore biosynthetic process','P','The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.','2013-10-27','NSRP'),(12395,19292,'tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate','P','The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate.','2013-10-27','NSRP'),(12396,19293,'tyrosine biosynthetic process, by oxidation of phenylalanine','P','The chemical reactions and pathways resulting in the formation of tyrosine by the oxidation of phenylalanine.','2013-10-27','NSRP'),(12397,19294,'keto-3-deoxy-D-manno-octulosonic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria.','2013-10-27','NSRP'),(12398,19295,'coenzyme M biosynthetic process','P','The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.','2013-10-27','NSRP'),(12399,19296,'coenzyme M metabolic process','P','The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.','2013-10-27','NSRP'),(12400,19297,'coenzyme B metabolic process','P','The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.','2013-10-27','NSRP'),(12401,19298,'coenzyme B biosynthetic process','P','The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes.','2013-10-27','NSRP'),(12402,19299,'rhamnose metabolic process','P','The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids.','2013-10-27','NSRP'),(12403,19300,'rhamnose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose.','2013-10-27','NSRP'),(12404,19301,'rhamnose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose.','2013-10-27','NSRP'),(12405,19302,'D-ribose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose).','2013-10-27','NSRP'),(12406,19303,'D-ribose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose).','2013-10-27','NSRP'),(12407,19304,'anaerobic rhamnose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen.','2013-10-27','NSRP'),(12408,19305,'dTDP-rhamnose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate.','2013-10-27','NSRP'),(12409,19306,'GDP-D-rhamnose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate.','2013-10-27','NSRP'),(12410,19307,'mannose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose.','2013-10-27','NSRP'),(12411,19308,'dTDP-mannose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate.','2013-10-27','NSRP'),(12412,19309,'mannose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose.','2013-10-27','NSRP'),(12413,19310,'inositol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms.','2013-10-27','NSRP'),(12414,19311,'sorbose metabolic process','P','The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid.','2013-10-27','NSRP'),(12415,19312,'L-sorbose metabolic process','P','The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol.','2013-10-27','NSRP'),(12416,19313,'allose metabolic process','P','The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3.','2013-10-27','NSRP'),(12417,19314,'D-allose metabolic process','P','The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose.','2013-10-27','NSRP'),(12418,19315,'D-allose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose.','2013-10-27','NSRP'),(12419,19316,'D-allose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose.','2013-10-27','NSRP'),(12420,19317,'fucose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose).','2013-10-27','NSRP'),(12421,19318,'hexose metabolic process','P','The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule.','2013-10-27','NSRP'),(12422,19319,'hexose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.','2013-10-27','NSRP'),(12423,19320,'hexose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule.','2013-10-27','NSRP'),(12424,19321,'pentose metabolic process','P','The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.','2013-10-27','NSRP'),(12425,19322,'pentose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.','2013-10-27','NSRP'),(12426,19323,'pentose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule.','2013-10-27','NSRP'),(12427,19324,'L-lyxose metabolic process','P','The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose.','2013-10-27','NSRP'),(12428,19325,'anaerobic fructose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen.','2013-10-27','NSRP'),(12429,19326,'nitrotoluene metabolic process','P','The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached.','2013-10-27','NSRP'),(12430,19327,'lead sulfide oxidation','P','The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate.','2013-10-27','NSRP'),(12431,19328,'anaerobic gallate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen.','2013-10-27','NSRP'),(12432,19329,'ammonia oxidation','P','The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons.','2013-10-27','NSRP'),(12433,19330,'aldoxime metabolic process','P','The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH.','2013-10-27','NSRP'),(12434,19331,'anaerobic respiration, using ammonium as electron donor','P','The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2.','2013-10-27','NSRP'),(12435,19332,'aerobic respiration, using nitrite as electron donor','P','The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species.','2013-10-27','NSRP'),(12436,19333,'denitrification pathway','P','The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen.','2013-10-27','NSRP'),(12437,19334,'p-cymene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants.','2013-10-27','NSRP'),(12438,19335,'3-methylquinoline catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring.','2013-10-27','NSRP'),(12439,19336,'phenol-containing compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring.','2013-10-27','NSRP'),(12440,19337,'tetrachloroethylene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines.','2013-10-27','NSRP'),(12441,19338,'pentachlorophenol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms.','2013-10-27','NSRP'),(12442,19339,'parathion catabolic process','P','The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition.','2013-10-27','NSRP'),(12443,19340,'dibenzofuran catabolic process','P','The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond.','2013-10-27','NSRP'),(12444,19341,'dibenzo-p-dioxin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds.','2013-10-27','NSRP'),(12445,19342,'trypanothione biosynthetic process','P','The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress.','2013-10-27','NSRP'),(12446,19343,'cysteine biosynthetic process via cystathionine','P','The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine.','2013-10-27','NSRP'),(12447,19344,'cysteine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid.','2013-10-27','NSRP'),(12448,19345,'cysteine biosynthetic process via S-sulfo-L-cysteine','P','The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine.','2013-10-27','NSRP'),(12449,19346,'transsulfuration','P','The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes.','2013-10-27','NSRP'),(12450,19347,'GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate.','2013-10-27','NSRP'),(12451,19348,'dolichol metabolic process','P','The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.','2013-10-27','NSRP'),(12452,19349,'ribitol metabolic process','P','The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin.','2013-10-27','NSRP'),(12453,19350,'teichoic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues.','2013-10-27','NSRP'),(12454,19351,'dethiobiotin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms.','2013-10-27','NSRP'),(12455,19352,'protoporphyrinogen IX biosynthetic process from glycine','P','The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine.','2013-10-27','NSRP'),(12456,19353,'protoporphyrinogen IX biosynthetic process from glutamate','P','The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate.','2013-10-27','NSRP'),(12457,19354,'siroheme biosynthetic process','P','The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings.','2013-10-27','NSRP'),(12458,19355,'nicotinamide nucleotide biosynthetic process from aspartate','P','The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate.','2013-10-27','NSRP'),(12459,19356,'nicotinate nucleotide biosynthetic process from tryptophan','P','The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan.','2013-10-27','NSRP'),(12460,19357,'nicotinate nucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid).','2013-10-27','NSRP'),(12461,19358,'nicotinate nucleotide salvage','P','The generation of nicotinate nucleotide without de novo synthesis.','2013-10-27','NSRP'),(12462,19359,'nicotinamide nucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.','2013-10-27','NSRP'),(12463,19360,'nicotinamide nucleotide biosynthetic process from niacinamide','P','The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide.','2013-10-27','NSRP'),(12464,19361,'2\'-(5\'\'-triphosphoribosyl)-3\'-dephospho-CoA biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 2\'-(5\'\'-triphosphoribosyl)-3\'-dephospho-CoA, a derivative of coenzyme A.','2013-10-27','NSRP'),(12465,19362,'pyridine nucleotide metabolic process','P','The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.','2013-10-27','NSRP'),(12466,19363,'pyridine nucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.','2013-10-27','NSRP'),(12467,19364,'pyridine nucleotide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base.','2013-10-27','NSRP'),(12468,19365,'pyridine nucleotide salvage','P','Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis.','2013-10-27','NSRP'),(12469,19367,'fatty acid elongation, saturated fatty acid','P','Elongation of a saturated fatty acid chain.','2013-10-27','NSRP'),(12470,19368,'fatty acid elongation, unsaturated fatty acid','P','Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced.','2013-10-27','NSRP'),(12471,19369,'arachidonic acid metabolic process','P','The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.','2013-10-27','NSRP'),(12472,19370,'leukotriene biosynthetic process','P','The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.','2013-10-27','NSRP'),(12473,19371,'cyclooxygenase pathway','P','The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.','2013-10-27','NSRP'),(12474,19372,'lipoxygenase pathway','P','The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase.','2013-10-27','NSRP'),(12475,19373,'epoxygenase P450 pathway','P','The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids.','2013-10-27','NSRP'),(12476,19374,'galactolipid metabolic process','P','The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine.','2013-10-27','NSRP'),(12477,19375,'galactolipid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine.','2013-10-27','NSRP'),(12478,19376,'galactolipid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine.','2013-10-27','NSRP'),(12479,19377,'glycolipid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).','2013-10-27','NSRP'),(12480,19379,'sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)','P','The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8).','2013-10-27','NSRP'),(12481,19380,'3-phenylpropionate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid.','2013-10-27','NSRP'),(12482,19381,'atrazine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide.','2013-10-27','NSRP'),(12483,19382,'carbon tetrachloride catabolic process','P','The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants.','2013-10-27','NSRP'),(12484,19383,'(+)-camphor catabolic process','P','The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone.','2013-10-27','NSRP'),(12485,19384,'caprolactam catabolic process','P','The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid.','2013-10-27','NSRP'),(12486,19385,'methanogenesis, from acetate','P','The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate.','2013-10-27','NSRP'),(12487,19386,'methanogenesis, from carbon dioxide','P','The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2).','2013-10-27','NSRP'),(12488,19387,'methanogenesis, from methanol','P','The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol.','2013-10-27','NSRP'),(12489,19388,'galactose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose.','2013-10-27','NSRP'),(12490,19389,'glucuronoside metabolic process','P','The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate.','2013-10-27','NSRP'),(12491,19390,'glucuronoside biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue.','2013-10-27','NSRP'),(12492,19391,'glucuronoside catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue.','2013-10-27','NSRP'),(12493,19392,'glucarate metabolic process','P','The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate.','2013-10-27','NSRP'),(12494,19393,'glucarate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid.','2013-10-27','NSRP'),(12495,19394,'glucarate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid.','2013-10-27','NSRP'),(12496,19395,'fatty acid oxidation','P','The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.','2013-10-27','NSRP'),(12497,19396,'gallate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid).','2013-10-27','NSRP'),(12498,19397,'gallate catabolic process via 2-pyrone-4,6-dicarboxylate','P','The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate.','2013-10-27','NSRP'),(12499,19398,'gallate catabolic process via gallate dioxygenase activity','P','The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, where the first step is the conversion of gallate to (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate catalyzed by gallate dioxygenase.','2013-10-27','NSRP'),(12500,19399,'cyclohexanol oxidation','P','The cyclohexanol metabolic process in which cyclohexanol is converted to adipate.','2013-10-27','NSRP'),(12501,19400,'alditol metabolic process','P','The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group.','2013-10-27','NSRP'),(12502,19401,'alditol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group.','2013-10-27','NSRP'),(12503,19402,'galactitol metabolic process','P','The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose.','2013-10-27','NSRP'),(12504,19403,'galactitol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose.','2013-10-27','NSRP'),(12505,19404,'galactitol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose.','2013-10-27','NSRP'),(12506,19405,'alditol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group.','2013-10-27','NSRP'),(12507,19406,'hexitol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule.','2013-10-27','NSRP'),(12508,19407,'hexitol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule.','2013-10-27','NSRP'),(12509,19408,'dolichol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units.','2013-10-27','NSRP'),(12510,19409,'aerobic respiration, using ammonia as electron donor','P','The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite.','2013-10-27','NSRP'),(12511,19410,'aerobic respiration, using carbon monoxide as electron donor','P','The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation.','2013-10-27','NSRP'),(12512,19411,'aerobic respiration, using ferrous ions as electron donor','P','The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide.','2013-10-27','NSRP'),(12513,19412,'aerobic respiration, using hydrogen as electron donor','P','The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water.','2013-10-27','NSRP'),(12514,19413,'acetate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid.','2013-10-27','NSRP'),(12515,19414,'aerobic respiration, using sulfur or sulfate as electron donor','P','An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized.','2013-10-27','NSRP'),(12516,19415,'acetate biosynthetic process from carbon monoxide','P','The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide.','2013-10-27','NSRP'),(12517,19416,'polythionate oxidation','P','The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor.','2013-10-27','NSRP'),(12518,19417,'sulfur oxidation','P','The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur.','2013-10-27','NSRP'),(12519,19418,'sulfide oxidation','P','The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate.','2013-10-27','NSRP'),(12520,19419,'sulfate reduction','P','The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate.','2013-10-27','NSRP'),(12521,19420,'dissimilatory sulfate reduction','P','The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide.','2013-10-27','NSRP'),(12522,19422,'disproportionation of elemental sulfur','P','The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2.','2013-10-27','NSRP'),(12523,19423,'sulfur oxidation, ferric ion-dependent','P','A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+).','2013-10-27','NSRP'),(12524,19424,'sulfide oxidation, using siroheme sulfite reductase','P','A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase.','2013-10-27','NSRP'),(12525,19426,'bisulfite reduction','P','The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite.','2013-10-27','NSRP'),(12526,19427,'acetyl-CoA biosynthetic process from acetate','P','The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.','2013-10-27','NSRP'),(12527,19428,'allantoin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.','2013-10-27','NSRP'),(12528,19429,'fluorene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents.','2013-10-27','NSRP'),(12529,19430,'removal of superoxide radicals','P','Any process involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).','2013-10-27','NSRP'),(12530,19431,'acetyl-CoA biosynthetic process from ethanol','P','The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde.','2013-10-27','NSRP'),(12531,19432,'triglyceride biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol.','2013-10-27','NSRP'),(12532,19433,'triglyceride catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.','2013-10-27','NSRP'),(12533,19434,'sophorosyloxydocosanoate metabolic process','P','The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6\',6\'\'-diacetate, an aromatic hydrocarbon.','2013-10-27','NSRP'),(12534,19435,'sophorosyloxydocosanoate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6\',6\'\'-diacetate.','2013-10-27','NSRP'),(12535,19436,'sophorosyloxydocosanoate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6\',6\'\'-diacetate.','2013-10-27','NSRP'),(12536,19438,'aromatic compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring.','2013-10-27','NSRP'),(12537,19439,'aromatic compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.','2013-10-27','NSRP'),(12538,19440,'tryptophan catabolic process to indole-3-acetate','P','The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate.','2013-10-27','NSRP'),(12539,19441,'tryptophan catabolic process to kynurenine','P','The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine.','2013-10-27','NSRP'),(12540,19442,'tryptophan catabolic process to acetyl-CoA','P','The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA.','2013-10-27','NSRP'),(12541,19443,'tryptophan catabolic process, using tryptophanase','P','OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1).','2013-10-27','NSRP'),(12542,19444,'tryptophan catabolic process to catechol','P','The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol.','2013-10-27','NSRP'),(12543,19445,'tyrosine catabolic process to fumarate','P','The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate.','2013-10-27','NSRP'),(12544,19446,'tyrosine catabolic process to phosphoenolpyruvate','P','The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate.','2013-10-27','NSRP'),(12545,19447,'D-cysteine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin.','2013-10-27','NSRP'),(12546,19448,'L-cysteine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid.','2013-10-27','NSRP'),(12547,19449,'L-cysteine catabolic process to hypotaurine','P','The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine.','2013-10-27','NSRP'),(12548,19450,'L-cysteine catabolic process to pyruvate','P','The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate.','2013-10-27','NSRP'),(12549,19451,'L-cysteine catabolic process to pyruvate, using cysteine dioxygenase','P','The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20).','2013-10-27','NSRP'),(12550,19452,'L-cysteine catabolic process to taurine','P','The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine.','2013-10-27','NSRP'),(12551,19453,'L-cysteine catabolic process via cystine','P','The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine.','2013-10-27','NSRP'),(12552,19454,'L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase','P','The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase (EC:1.8.4.4).','2013-10-27','NSRP'),(12553,19455,'L-cysteine catabolic process via cystine, using cystine reductase','P','The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase (EC:1.8.1.6).','2013-10-27','NSRP'),(12554,19456,'L-cysteine catabolic process via cystine, using cysteine transaminase','P','The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase (EC:2.6.1.3).','2013-10-27','NSRP'),(12555,19457,'methionine catabolic process to succinyl-CoA','P','The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA.','2013-10-27','NSRP'),(12556,19458,'methionine catabolic process via 2-oxobutanoate','P','The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate.','2013-10-27','NSRP'),(12557,19460,'glutamine catabolic process to fumarate','P','The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate.','2013-10-27','NSRP'),(12558,19461,'glutamine catabolic process to fumarate, using glutamate synthase (NADPH)','P','The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13).','2013-10-27','NSRP'),(12559,19462,'glutamine catabolic process to fumarate, using glutaminase','P','The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2).','2013-10-27','NSRP'),(12560,19463,'glycine catabolic process to creatine','P','The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine.','2013-10-27','NSRP'),(12561,19464,'glycine decarboxylation via glycine cleavage system','P','The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.','2013-10-27','NSRP'),(12562,19465,'aspartate transamidation','P','The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group.','2013-10-27','NSRP'),(12563,19466,'ornithine catabolic process via proline','P','The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline.','2013-10-27','NSRP'),(12564,19467,'ornithine catabolic process, by decarboxylation','P','The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation.','2013-10-27','NSRP'),(12565,19468,'nopaline catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative.','2013-10-27','NSRP'),(12566,19469,'octopine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine.','2013-10-27','NSRP'),(12567,19470,'4-hydroxyproline catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline.','2013-10-27','NSRP'),(12568,19471,'4-hydroxyproline metabolic process','P','The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls.','2013-10-27','NSRP'),(12569,19472,'4-hydroxyproline biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline.','2013-10-27','NSRP'),(12570,19473,'L-lysine catabolic process to glutarate, by acetylation','P','The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation.','2013-10-27','NSRP'),(12571,19474,'L-lysine catabolic process to acetyl-CoA','P','The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA.','2013-10-27','NSRP'),(12572,19475,'L-lysine catabolic process to acetate','P','The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate.','2013-10-27','NSRP'),(12573,19476,'D-lysine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid.','2013-10-27','NSRP'),(12574,19477,'L-lysine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid.','2013-10-27','NSRP'),(12575,19478,'D-amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids.','2013-10-27','NSRP'),(12576,19479,'L-alanine oxidation to D-lactate and ammonia','P','The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia.','2013-10-27','NSRP'),(12577,19480,'L-alanine oxidation to pyruvate via D-alanine','P','The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate.','2013-10-27','NSRP'),(12578,19481,'L-alanine catabolic process, by transamination','P','The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination.','2013-10-27','NSRP'),(12579,19482,'beta-alanine metabolic process','P','The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.','2013-10-27','NSRP'),(12580,19483,'beta-alanine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.','2013-10-27','NSRP'),(12581,19484,'beta-alanine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins.','2013-10-27','NSRP'),(12582,19485,'beta-alanine catabolic process to L-alanine','P','The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine.','2013-10-27','NSRP'),(12583,19486,'beta-alanine catabolic process to mevalonate semialdehyde, by transamination','P','The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination.','2013-10-27','NSRP'),(12584,19487,'anaerobic acetylene catabolic process','P','The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen.','2013-10-27','NSRP'),(12585,19488,'ribitol catabolic process to xylulose 5-phosphate','P','The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate.','2013-10-27','NSRP'),(12586,19489,'methylgallate metabolic process','P','The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid.','2013-10-27','NSRP'),(12587,19490,'2-aminobenzenesulfonate desulfonation','P','The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines.','2013-10-27','NSRP'),(12588,19491,'ectoine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria.','2013-10-27','NSRP'),(12589,19492,'proline salvage','P','Any process which produces the amino acid proline from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(12590,19493,'arginine catabolic process to proline','P','The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline.','2013-10-27','NSRP'),(12591,19495,'proline catabolic process to 2-oxoglutarate','P','The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate.','2013-10-27','NSRP'),(12592,19496,'serine-isocitrate lyase pathway','P','A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide.','2013-10-27','NSRP'),(12593,19497,'hexachlorocyclohexane metabolic process','P','The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution.','2013-10-27','NSRP'),(12594,19498,'n-octane oxidation','P','The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA.','2013-10-27','NSRP'),(12595,19499,'cyanide metabolic process','P','The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain.','2013-10-27','NSRP'),(12596,19500,'cyanide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration.','2013-10-27','NSRP'),(12597,19501,'arsonoacetate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom.','2013-10-27','NSRP'),(12598,19502,'stachydrine metabolic process','P','The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants.','2013-10-27','NSRP'),(12599,19503,'stachydrine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline.','2013-10-27','NSRP'),(12600,19504,'stachydrine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline.','2013-10-27','NSRP'),(12601,19505,'resorcinol metabolic process','P','The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic.','2013-10-27','NSRP'),(12602,19506,'phenylmercury acetate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group.','2013-10-27','NSRP'),(12603,19507,'pyridine metabolic process','P','The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor.','2013-10-27','NSRP'),(12604,19508,'2,5-dihydroxypyridine catabolic process to fumarate','P','The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate.','2013-10-27','NSRP'),(12605,19509,'L-methionine salvage from methylthioadenosine','P','The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine.','2013-10-27','NSRP'),(12606,19510,'S-adenosylhomocysteine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine.','2013-10-27','NSRP'),(12607,19511,'peptidyl-proline hydroxylation','P','The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline.','2013-10-27','NSRP'),(12608,19512,'lactose catabolic process via tagatose-6-phosphate','P','The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate.','2013-10-27','NSRP'),(12609,19513,'lactose catabolic process, using glucoside 3-dehydrogenase','P','The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13).','2013-10-27','NSRP'),(12610,19514,'lactose hydrolysis','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12611,19515,'lactose catabolic process via UDP-galactose','P','The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose.','2013-10-27','NSRP'),(12612,19516,'lactate oxidation','P','The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons.','2013-10-27','NSRP'),(12613,19517,'L-threonine catabolic process to D-lactate','P','The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate.','2013-10-27','NSRP'),(12614,19518,'L-threonine catabolic process to glycine','P','The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine.','2013-10-27','NSRP'),(12615,19519,'pentitol metabolic process','P','The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule.','2013-10-27','NSRP'),(12616,19520,'aldonic acid metabolic process','P','The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group.','2013-10-27','NSRP'),(12617,19521,'D-gluconate metabolic process','P','The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose.','2013-10-27','NSRP'),(12618,19522,'ketogluconate metabolic process','P','The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group.','2013-10-27','NSRP'),(12619,19523,'L-idonate metabolic process','P','The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose.','2013-10-27','NSRP'),(12620,19524,'keto-D-gluconate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose.','2013-10-27','NSRP'),(12621,19525,'keto-D-gluconate metabolic process','P','The chemical reactions and pathways involving keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose.','2013-10-27','NSRP'),(12622,19526,'pentitol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule.','2013-10-27','NSRP'),(12623,19527,'pentitol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule.','2013-10-27','NSRP'),(12624,19528,'D-arabitol catabolic process to xylulose 5-phosphate','P','The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate.','2013-10-27','NSRP'),(12625,19529,'taurine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.','2013-10-27','NSRP'),(12626,19530,'taurine metabolic process','P','The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.','2013-10-27','NSRP'),(12627,19531,'oxalate transmembrane transporter activity','F','Catalysis of the transfer of oxalate from one side of the membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.','2013-10-27','NSRP'),(12628,19532,'oxalate transport','P','The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.','2013-10-27','NSRP'),(12629,19533,'cellobiose transport','P','The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose.','2013-10-27','NSRP'),(12630,19534,'toxin transporter activity','F','Enables the directed movement of a toxin into, out of or within a cell, or between cells. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.','2013-10-27','NSRP'),(12631,19535,'ferric-vibriobactin transmembrane transporter activity','F','Catalysis of the transfer of ferric-vibriobactin ions from one side of a membrane to the other.','2013-10-27','NSRP'),(12632,19536,'vibriobactin metabolic process','P','The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae.','2013-10-27','NSRP'),(12633,19537,'vibriobactin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae.','2013-10-27','NSRP'),(12634,19538,'protein metabolic process','P','The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification.','2013-10-27','NSRP'),(12635,19539,'siderophore biosynthetic process from hydroxamic acid','P','The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid.','2013-10-27','NSRP'),(12636,19540,'siderophore biosynthetic process from catechol','P','The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol.','2013-10-27','NSRP'),(12637,19541,'propionate metabolic process','P','The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants.','2013-10-27','NSRP'),(12638,19542,'propionate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid.','2013-10-27','NSRP'),(12639,19543,'propionate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.','2013-10-27','NSRP'),(12640,19544,'arginine catabolic process to glutamate','P','The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate.','2013-10-27','NSRP'),(12641,19545,'arginine catabolic process to succinate','P','The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate.','2013-10-27','NSRP'),(12642,19546,'arginine deiminase pathway','P','The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase.','2013-10-27','NSRP'),(12643,19547,'arginine catabolic process to ornithine','P','The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine.','2013-10-27','NSRP'),(12644,19548,'arginine catabolic process to spermine','P','The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine.','2013-10-27','NSRP'),(12645,19549,'glutamate catabolic process to succinate via succinate semialdehyde','P','The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase.','2013-10-27','NSRP'),(12646,19550,'glutamate catabolic process to aspartate','P','The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate.','2013-10-27','NSRP'),(12647,19551,'glutamate catabolic process to 2-oxoglutarate','P','The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate.','2013-10-27','NSRP'),(12648,19552,'glutamate catabolic process via 2-hydroxyglutarate','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12649,19553,'glutamate catabolic process via L-citramalate','P','The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate.','2013-10-27','NSRP'),(12650,19554,'glutamate catabolic process to oxaloacetate','P','The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate.','2013-10-27','NSRP'),(12651,19555,'glutamate catabolic process to ornithine','P','The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine.','2013-10-27','NSRP'),(12652,19556,'histidine catabolic process to glutamate and formamide','P','The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide.','2013-10-27','NSRP'),(12653,19557,'histidine catabolic process to glutamate and formate','P','The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate.','2013-10-27','NSRP'),(12654,19558,'histidine catabolic process to 2-oxoglutarate','P','The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate.','2013-10-27','NSRP'),(12655,19559,'histidine catabolic process to imidazol-5-yl-lactate','P','The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate.','2013-10-27','NSRP'),(12656,19560,'histidine catabolic process to hydantoin-5-propionate','P','The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate.','2013-10-27','NSRP'),(12657,19561,'anaerobic phenylalanine oxidation','P','The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde.','2013-10-27','NSRP'),(12658,19562,'phenylalanine catabolic process to phosphoenolpyruvate','P','The chemical reactions and pathways resulting in the breakdown of phenylalanine into other compounds, including phosphoenolpyruvate.','2013-10-27','NSRP'),(12659,19563,'glycerol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.','2013-10-27','NSRP'),(12660,19564,'aerobic glycerol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen.','2013-10-27','NSRP'),(12661,19566,'arabinose metabolic process','P','The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides.','2013-10-27','NSRP'),(12662,19567,'arabinose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose.','2013-10-27','NSRP'),(12663,19568,'arabinose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose.','2013-10-27','NSRP'),(12664,19569,'L-arabinose catabolic process to xylulose 5-phosphate','P','The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate.','2013-10-27','NSRP'),(12665,19570,'L-arabinose catabolic process to 2-oxoglutarate','P','The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate.','2013-10-27','NSRP'),(12666,19571,'D-arabinose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose.','2013-10-27','NSRP'),(12667,19572,'L-arabinose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose.','2013-10-27','NSRP'),(12668,19573,'D-arabinose catabolic process to xylulose 5-phosphate','P','The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate.','2013-10-27','NSRP'),(12669,19574,'sucrose catabolic process via 3\'-ketosucrose','P','The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3\'-ketosucrose. 3\'-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose can then be converted to glucose.','2013-10-27','NSRP'),(12670,19575,'sucrose catabolic process, using beta-fructofuranosidase','P','OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26).','2013-10-27','NSRP'),(12671,19576,'aerobic fructose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen.','2013-10-27','NSRP'),(12672,19577,'aldaric acid metabolic process','P','The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group.','2013-10-27','NSRP'),(12673,19578,'aldaric acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group.','2013-10-27','NSRP'),(12674,19579,'aldaric acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group.','2013-10-27','NSRP'),(12675,19580,'galactarate metabolic process','P','The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose.','2013-10-27','NSRP'),(12676,19582,'D-galactarate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-galactarate, the D-enantiomer of the anion of galactaric acid.','2013-07-14','NSRP'),(12677,19583,'galactonate metabolic process','P','The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose.','2013-10-27','NSRP'),(12678,19584,'galactonate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid.','2013-10-27','NSRP'),(12679,19585,'glucuronate metabolic process','P','The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.','2013-10-27','NSRP'),(12680,19586,'galacturonate metabolic process','P','The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group.','2013-10-27','NSRP'),(12681,19588,'anaerobic glycerol catabolic process','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP.','2013-10-27','NSRP');
INSERT INTO `GO` VALUES (12682,19589,'anaerobic glycerol catabolic process to propane-1,3-diol','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water.','2013-10-27','NSRP'),(12683,19590,'L-arabitol catabolic process to xylulose 5-phosphate','P','The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate.','2013-10-27','NSRP'),(12684,19592,'mannitol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group.','2013-10-27','NSRP'),(12685,19593,'mannitol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group.','2013-10-27','NSRP'),(12686,19594,'mannitol metabolic process','P','The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group.','2013-10-27','NSRP'),(12687,19595,'non-phosphorylated glucose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose.','2013-10-27','NSRP'),(12688,19596,'mandelate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic.','2013-10-27','NSRP'),(12689,19597,'(R)-mandelate catabolic process to benzoate','P','The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate.','2013-10-27','NSRP'),(12690,19598,'(R)-mandelate catabolic process to catechol','P','The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol.','2013-10-27','NSRP'),(12691,19599,'(R)-4-hydroxymandelate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid.','2013-10-27','NSRP'),(12692,19600,'toluene oxidation','P','The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene.','2013-10-27','NSRP'),(12693,19601,'toluene oxidation via 2-hydroxytoluene','P','The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol).','2013-10-27','NSRP'),(12694,19602,'toluene oxidation via 3-hydroxytoluene','P','The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol).','2013-10-27','NSRP'),(12695,19603,'toluene oxidation via 4-hydroxytoluene','P','The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol).','2013-10-27','NSRP'),(12696,19604,'toluene oxidation to catechol','P','The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2).','2013-10-27','NSRP'),(12697,19605,'butyrate metabolic process','P','The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid.','2013-10-27','NSRP'),(12698,19606,'2-oxobutyrate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2.','2013-10-27','NSRP'),(12699,19607,'phenylethylamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds.','2013-10-27','NSRP'),(12700,19608,'nicotine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine.','2013-10-27','NSRP'),(12701,19609,'3-hydroxyphenylacetate metabolic process','P','The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate.','2013-10-27','NSRP'),(12702,19610,'3-hydroxyphenylacetate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate.','2013-10-27','NSRP'),(12703,19611,'4-toluenecarboxylate metabolic process','P','The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule.','2013-10-27','NSRP'),(12704,19612,'4-toluenecarboxylate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule.','2013-10-27','NSRP'),(12705,19614,'catechol-containing compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.','2013-10-27','NSRP'),(12706,19615,'catechol catabolic process, ortho-cleavage','P','The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups.','2013-10-27','NSRP'),(12707,19616,'catechol catabolic process, meta-cleavage','P','The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom.','2013-10-27','NSRP'),(12708,19617,'protocatechuate catabolic process, meta-cleavage','P','The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate.','2013-10-27','NSRP'),(12709,19618,'protocatechuate catabolic process, ortho-cleavage','P','The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate.','2013-10-27','NSRP'),(12710,19619,'protocatechuate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid.','2013-10-27','NSRP'),(12711,19620,'aerobic benzoate metabolic process','P','The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen.','2013-10-27','NSRP'),(12712,19621,'creatinine catabolic process to formate','P','The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate.','2013-10-27','NSRP'),(12713,19622,'3-(3-hydroxy)phenylpropionate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate.','2013-10-27','NSRP'),(12714,19623,'atrazine catabolic process to urea','P','The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea.','2013-10-27','NSRP'),(12715,19624,'atrazine catabolic process to isopropylamine','P','The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine.','2013-10-27','NSRP'),(12716,19625,'atrazine catabolic process to cyanuric acid','P','The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid.','2013-10-27','NSRP'),(12717,19626,'short-chain fatty acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6.','2013-10-27','NSRP'),(12718,19627,'urea metabolic process','P','The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2.','2013-10-27','NSRP'),(12719,19628,'urate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine.','2013-10-27','NSRP'),(12720,19629,'propionate catabolic process, 2-methylcitrate cycle','P','The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.','2013-10-27','NSRP'),(12721,19630,'quinate metabolic process','P','The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine.','2013-10-27','NSRP'),(12722,19631,'quinate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid.','2013-10-27','NSRP'),(12723,19632,'shikimate metabolic process','P','The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.','2013-10-27','NSRP'),(12724,19633,'shikimate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid.','2013-10-27','NSRP'),(12725,19634,'organic phosphonate metabolic process','P','The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.','2013-10-27','NSRP'),(12726,19635,'2-aminoethylphosphonate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine.','2013-10-27','NSRP'),(12727,19636,'phosphonoacetate metabolic process','P','The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue.','2013-10-27','NSRP'),(12728,19637,'organophosphate metabolic process','P','The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound.','2013-10-27','NSRP'),(12729,19638,'6-hydroxycineole metabolic process','P','The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2.','2013-10-27','NSRP'),(12730,19639,'6-hydroxycineole catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2.','2013-10-27','NSRP'),(12731,19640,'glucuronate catabolic process to xylulose 5-phosphate','P','The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate.','2013-10-27','NSRP'),(12732,19643,'reductive tricarboxylic acid cycle','P','A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.','2013-10-27','NSRP'),(12733,19645,'anaerobic electron transport chain','P','A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient.','2013-10-27','NSRP'),(12734,19646,'aerobic electron transport chain','P','A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient.','2013-10-27','NSRP'),(12735,19647,'formaldehyde assimilation via ribulose monophosphate cycle','P','The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde.','2013-10-27','NSRP'),(12736,19648,'formaldehyde assimilation via xylulose monophosphate cycle','P','The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds.','2013-10-27','NSRP'),(12737,19649,'formaldehyde assimilation','P','The pathways in which formaldehyde is processed and used as a carbon source for the cell.','2013-10-27','NSRP'),(12738,19650,'glucose catabolic process to butanediol','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into 2,3-butanediol and other substances; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia.','2013-10-27','NSRP'),(12739,19651,'citrate catabolic process to diacetyl','P','The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12740,19652,'lactate fermentation to propionate and acetate','P','The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP).','2013-10-27','NSRP'),(12741,19653,'anaerobic purine nucleobase catabolic process','P','The anaerobic chemical reactions and pathways resulting in the breakdown of purine nucleobases, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12742,19654,'acetate fermentation','P','The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12743,19655,'glucose catabolic process to ethanol','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose.','2013-10-27','NSRP'),(12744,19656,'glucose catabolic process to D-lactate and ethanol','P','The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule.','2013-10-27','NSRP'),(12745,19657,'pyruvate fermentation to propionate','P','The anaerobic conversion of pyruvate to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate.','2013-10-27','NSRP'),(12746,19658,'glucose catabolic process to lactate and acetate','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12747,19659,'glucose catabolic process to lactate','P','The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP).','2013-10-27','NSRP'),(12748,19660,'glycolytic fermentation','P','Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway.','2013-10-27','NSRP'),(12749,19661,'glucose catabolic process to lactate via pyruvate','P','The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via pyruvate, yielding energy in the form of adenosine triphosphate (ATP).','2013-10-27','NSRP'),(12750,19662,'non-glycolytic fermentation','P','Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway.','2013-10-27','NSRP'),(12751,19664,'glucose catabolic process to mixed acids','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12752,19665,'anaerobic amino acid catabolic process','P','The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12753,19666,'nitrogenous compound fermentation','P','The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12754,19667,'anaerobic L-alanine catabolic process','P','The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12755,19668,'anaerobic catabolism of pairs of amino acids','P','The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP.','2013-10-27','NSRP'),(12756,19669,'anaerobic glycine catabolic process','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12757,19670,'anaerobic glutamate catabolic process','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12758,19671,'glutamate catabolic process via mesaconate and citramalate','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12759,19672,'ethanol-acetate fermentation to butyrate and caproate','P','The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP.','2013-10-27','NSRP'),(12760,19673,'GDP-mannose metabolic process','P','The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.','2013-10-27','NSRP'),(12761,19674,'NAD metabolic process','P','The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.','2013-10-27','NSRP'),(12762,19675,'NAD phosphorylation and dephosphorylation','P','OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid.','2013-10-27','NSRP'),(12763,19676,'ammonia assimilation cycle','P','The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.','2013-10-27','NSRP'),(12764,19677,'NAD catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH.','2013-10-27','NSRP'),(12765,19678,'propionate metabolic process, methylmalonyl pathway','P','The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway.','2013-10-27','NSRP'),(12766,19679,'propionate metabolic process, methylcitrate cycle','P','The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.','2013-10-27','NSRP'),(12767,19680,'L-methylmalonyl-CoA biosynthetic process','P','The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA.','2013-10-27','NSRP'),(12768,19681,'acetyl-CoA assimilation pathway','P','The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell.','2013-10-27','NSRP'),(12769,19682,'glyceraldehyde-3-phosphate metabolic process','P','The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis.','2013-10-27','NSRP'),(12770,19683,'glyceraldehyde-3-phosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis.','2013-10-27','NSRP'),(12771,19684,'photosynthesis, light reaction','P','The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I.','2013-10-27','NSRP'),(12772,19685,'photosynthesis, dark reaction','P','A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the \'light\' reactions.','2013-10-27','NSRP'),(12773,19686,'purine nucleoside interconversion','P','The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside.','2013-10-27','NSRP'),(12774,19687,'pyruvate biosynthetic process from acetate','P','The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate.','2013-10-27','NSRP'),(12775,19688,'purine deoxyribonucleoside interconversion','P','The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside.','2013-10-27','NSRP'),(12776,19689,'pyrimidine nucleoside interconversion','P','The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside.','2013-10-27','NSRP'),(12777,19690,'pyrimidine deoxyribonucleoside interconversion','P','The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside.','2013-10-27','NSRP'),(12778,19692,'deoxyribose phosphate metabolic process','P','The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose.','2013-10-27','NSRP'),(12779,19693,'ribose phosphate metabolic process','P','The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar.','2013-10-27','NSRP'),(12780,19694,'alkanesulfonate metabolic process','P','The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.','2013-10-27','NSRP'),(12781,19695,'choline metabolic process','P','The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.','2013-10-27','NSRP'),(12782,19696,'toluene oxidation via toluene-cis-1,2-dihydrodiol','P','The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol.','2013-10-27','NSRP'),(12783,19697,'L-xylitol catabolic process to xylulose 5-phosphate','P','The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate.','2013-10-27','NSRP'),(12784,19698,'D-galacturonate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid.','2013-10-27','NSRP'),(12785,19700,'organic phosphonate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.','2013-10-27','NSRP'),(12786,19701,'peptidyl-arginine N5-methylation','P','The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine.','2013-10-27','NSRP'),(12787,19702,'protein-arginine N5-methyltransferase activity','F','Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues.','2013-10-27','NSRP'),(12788,19703,'coenzyme A-peptidyl-cysteine covalent linking','P','The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide.','2013-10-27','NSRP'),(12789,19704,'peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine','P','The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine.','2013-10-27','NSRP'),(12790,19705,'protein-cysteine S-myristoyltransferase activity','F','Catalysis of the transfer of a myristoyl group to a sulfur atom on a cysteine residue of a protein molecule.','2013-10-27','NSRP'),(12791,19706,'protein-cysteine S-palmitoyltransferase activity','F','Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule.','2013-10-27','NSRP'),(12792,19707,'protein-cysteine S-acyltransferase activity','F','Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule.','2013-10-27','NSRP'),(12793,19708,'peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine','P','The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins.','2013-10-27','NSRP'),(12794,19709,'iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide','P','The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase.','2013-10-27','NSRP'),(12795,19710,'peptidyl-asparagine methylation','P','The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine.','2013-10-27','NSRP'),(12796,19711,'peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid','P','The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid.','2013-10-27','NSRP'),(12797,19712,'peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid','P','The methyl esterification of peptidyl-glutamic acid.','2013-10-27','NSRP'),(12798,19713,'peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine','P','The coupled methyl esterification and deamidation of peptidyl-glutamine.','2013-10-27','NSRP'),(12799,19714,'peptidyl-glutamine esterification','P','The addition of an ester group to a glutamine residue in a protein.','2013-10-27','NSRP'),(12800,19715,'peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid','P','The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16).','2013-10-27','NSRP'),(12801,19716,'N-terminal peptidyl-alanine monomethylation','P','The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine.','2013-10-27','NSRP'),(12802,19717,'synaptosome','C','OBSOLETE: Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma.','2013-10-27','NSRP'),(12803,19718,'rough microsome','C','OBSOLETE: Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside.','2013-10-27','NSRP'),(12804,19719,'smooth microsome','C','OBSOLETE: Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes.','2013-10-27','NSRP'),(12805,19720,'Mo-molybdopterin cofactor metabolic process','P','The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.','2013-10-27','NSRP'),(12806,19722,'calcium-mediated signaling','P','Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.','2013-10-27','NSRP'),(12807,19724,'B cell mediated immunity','P','Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells.','2013-10-27','NSRP'),(12808,19725,'cellular homeostasis','P','Any process involved in the maintenance of an internal steady state at the level of the cell.','2013-10-27','NSRP'),(12809,19726,'mevaldate reductase (NADPH) activity','F','Catalysis of the reaction: (R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH.','2013-10-27','NSRP'),(12810,19727,'mevaldate reductase (NAD+) activity','F','Catalysis of the reaction: (R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH.','2013-10-27','NSRP'),(12811,19728,'peptidyl-allysine oxidation to 2-aminoadipic acid','P','The oxidation of allysine to 2-aminoadipic acid.','2013-10-27','NSRP'),(12812,19729,'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine','P','The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons.','2013-10-27','NSRP'),(12813,19730,'antimicrobial humoral response','P','An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.','2013-10-27','NSRP'),(12814,19731,'antibacterial humoral response','P','An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.','2013-10-27','NSRP'),(12815,19732,'antifungal humoral response','P','An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster.','2013-10-27','NSRP'),(12816,19736,'peptidyl-sarcosine incorporation','P','The incorporation of sarcosine (N-methylglycine) into non-coded peptides.','2013-10-27','NSRP'),(12817,19740,'nitrogen utilization','P','A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism\'s metabolism.','2013-10-27','NSRP'),(12818,19741,'pentacyclic triterpenoid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings.','2013-10-27','NSRP'),(12819,19742,'pentacyclic triterpenoid metabolic process','P','The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings.','2013-10-27','NSRP'),(12820,19743,'hopanoid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus.','2013-10-27','NSRP'),(12821,19744,'hopanoid metabolic process','P','The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus.','2013-10-27','NSRP'),(12822,19745,'pentacyclic triterpenoid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings.','2013-10-27','NSRP'),(12823,19746,'hopanoid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus.','2013-10-27','NSRP'),(12824,19747,'regulation of isoprenoid metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids.','2013-10-27','NSRP'),(12825,19748,'secondary metabolic process','P','The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients.','2013-10-27','NSRP'),(12826,19749,'cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte','P','The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte.','2013-10-27','NSRP'),(12827,19750,'chloroplast localization','P','Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants.','2013-10-27','NSRP'),(12828,19751,'polyol metabolic process','P','The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms.','2013-10-27','NSRP'),(12829,19752,'carboxylic acid metabolic process','P','The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).','2013-10-27','NSRP'),(12830,19755,'one-carbon compound transport','P','The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(12831,19756,'cyanogenic glycoside biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits.','2013-10-27','NSRP'),(12832,19757,'glycosinolate metabolic process','P','The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae.','2013-10-27','NSRP'),(12833,19758,'glycosinolate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae.','2013-10-27','NSRP'),(12834,19759,'glycosinolate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae.','2013-10-27','NSRP'),(12835,19760,'glucosinolate metabolic process','P','The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans.','2013-10-27','NSRP'),(12836,19761,'glucosinolate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.','2013-10-27','NSRP'),(12837,19762,'glucosinolate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae.','2013-10-27','NSRP'),(12838,19763,'immunoglobulin receptor activity','F','Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(12839,19764,'high affinity Fc receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12840,19765,'low affinity Fc receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12841,19766,'IgA receptor activity','F','Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(12842,19767,'IgE receptor activity','F','Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(12843,19768,'high affinity IgE receptor activity','F','Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(12844,19769,'low affinity IgE receptor activity','F','Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(12845,19770,'IgG receptor activity','F','Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(12846,19771,'high affinity IgG receptor activity','F','Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(12847,19772,'low affinity IgG receptor activity','F','Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(12848,19773,'proteasome core complex, alpha-subunit complex','C','The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus.','2013-10-27','NSRP'),(12849,19774,'proteasome core complex, beta-subunit complex','C','The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus.','2013-10-27','NSRP'),(12850,19775,'FAT10 ligase activity','F','Catalysis of the covalent attachment of the ubiquitin-like protein FAT10 to other proteins.','2013-10-27','NSRP'),(12851,19776,'Atg8 ligase activity','F','Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate.','2013-10-27','NSRP'),(12852,19777,'Atg12 ligase activity','F','Catalysis of the covalent attachment of the ubiquitin-like protein Atg12 to other proteins.','2013-10-27','NSRP'),(12853,19778,'APG12 activating enzyme activity','F','Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond.','2013-10-27','NSRP'),(12854,19779,'APG8 activating enzyme activity','F','Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond.','2013-10-27','NSRP'),(12855,19780,'FAT10 activating enzyme activity','F','Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond.','2013-10-27','NSRP'),(12856,19781,'NEDD8 activating enzyme activity','F','Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade.','2013-10-27','NSRP'),(12857,19782,'ISG15 activating enzyme activity','F','Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond.','2013-10-27','NSRP'),(12858,19783,'small conjugating protein-specific protease activity','F','Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated.','2013-10-27','NSRP'),(12859,19784,'NEDD8-specific protease activity','F','Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates.','2013-10-27','NSRP'),(12860,19785,'ISG15-specific protease activity','F','Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates.','2013-10-27','NSRP'),(12861,19786,'APG8-specific protease activity','F','Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier.','2013-10-27','NSRP'),(12862,19787,'small conjugating protein ligase activity','F','Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase.','2013-10-27','NSRP'),(12863,19788,'NEDD8 ligase activity','F','Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of the small ubiquitin-related modifier NEDD8 and a substrate lysine residue.','2013-10-27','NSRP'),(12864,19789,'SUMO ligase activity','F','Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal glycine residues of the small ubiquitin-related modifier SUMO and a substrate lysine residue, leading to the formation of predominately monosumoylated proteins with modified function.','2013-10-27','NSRP'),(12865,19790,'ubiquitin-like hydrolase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12866,19791,'FAT10 hydrolase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12867,19792,'APG12 hydrolase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12868,19793,'ISG15 carrier activity','F','Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other.','2013-10-27','NSRP'),(12869,19794,'nonprotein amino acid metabolic process','P','OBSOLETE. The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins.','2013-10-27','NSRP'),(12870,19795,'nonprotein amino acid biosynthetic process','P','OBSOLETE. The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins.','2013-10-27','NSRP'),(12871,19796,'nonprotein amino acid catabolic process','P','OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins.','2013-10-27','NSRP'),(12872,19797,'procollagen-proline 3-dioxygenase activity','F','Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2.','2013-10-27','NSRP'),(12873,19798,'procollagen-proline dioxygenase activity','F','Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2.','2013-10-27','NSRP'),(12874,19799,'tubulin N-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine.','2013-10-27','NSRP'),(12875,19800,'peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan','P','The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain.','2013-10-27','NSRP'),(12876,19801,'cyclization of asparagine involved in intein-mediated protein splicing','P','The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing.','2013-10-27','NSRP'),(12877,19802,'cyclization of glutamine involved in intein-mediated protein splicing','P','The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing.','2013-10-27','NSRP'),(12878,19803,'peptidyl-aspartic acid carboxylation','P','The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid.','2013-10-27','NSRP'),(12879,19804,'quinolinate synthetase complex','C','OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate.','2013-10-27','NSRP'),(12880,19805,'quinolinate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid.','2013-10-27','NSRP'),(12881,19806,'bromide peroxidase activity','F','Catalysis of the reaction: 2 R-H + 2 bromide + hydrogen peroxide = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide.','2013-10-27','NSRP'),(12882,19807,'aspartoacylase activity','F','Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate.','2013-10-27','NSRP'),(12883,19808,'polyamine binding','F','Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups.','2013-10-27','NSRP'),(12884,19809,'spermidine binding','F','Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane.','2013-10-27','NSRP'),(12885,19810,'putrescine binding','F','Interacting selectively and non-covalently with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.','2013-10-27','NSRP'),(12886,19811,'cocaine binding','F','Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis.','2013-10-27','NSRP'),(12887,19812,'Type I site-specific deoxyribonuclease complex','C','A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell.','2013-10-27','NSRP'),(12888,19813,'Type III site-specific deoxyribonuclease complex','C','A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell.','2013-10-27','NSRP'),(12889,19814,'immunoglobulin complex','C','A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.','2013-10-27','NSRP'),(12890,19815,'B cell receptor complex','C','An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.','2013-10-27','NSRP'),(12891,19816,'B cell receptor accessory molecule complex','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12892,19817,'vesicle fusion with peroxisome','P','The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome.','2013-10-27','NSRP'),(12893,19819,'P1 peroxisome','C','A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms.','2013-10-27','NSRP'),(12894,19820,'P2 peroxisome','C','A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed.','2013-10-27','NSRP'),(12895,19821,'P3 peroxisome','C','A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content.','2013-10-27','NSRP'),(12896,19822,'P4 peroxisome','C','A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content.','2013-10-27','NSRP'),(12897,19823,'P5 peroxisome','C','A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content.','2013-10-27','NSRP'),(12898,19824,'P6 peroxisome','C','A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes.','2013-10-27','NSRP'),(12899,19825,'oxygen binding','F','Interacting selectively and non-covalently with oxygen (O2).','2013-10-27','NSRP'),(12900,19826,'oxygen sensor activity','F','Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2).','2013-10-27','NSRP'),(12901,19827,'stem cell maintenance','P','The process in which an organism retains a population of stem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate.','2013-10-27','NSRP'),(12902,19828,'aspartic-type endopeptidase inhibitor activity','F','Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process.','2013-10-27','NSRP'),(12903,19829,'cation-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).','2013-10-27','NSRP'),(12904,19830,'cadmium sensitivity/resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12905,19831,'chromate sensitivity/resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12906,19832,'mercuric sensitivity/resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12907,19833,'ice nucleation activity','F','OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism\'s cells to freeze and die, and fish use them to protect themselves from intracellular ice formation.','2013-10-27','NSRP'),(12908,19834,'phospholipase A2 inhibitor activity','F','Stops, prevents or reduces the activity of the enzyme phospholipase A2.','2013-10-27','NSRP'),(12909,19835,'cytolysis','P','The rupture of cell membranes and the loss of cytoplasm.','2013-10-27','NSRP'),(12910,19836,'hemolysis by symbiont of host erythrocytes','P','The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(12911,19837,'herbicide susceptibility/resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12912,19838,'growth factor binding','F','Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.','2013-10-27','NSRP'),(12913,19840,'isoprenoid binding','F','Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.','2013-10-27','NSRP'),(12914,19841,'retinol binding','F','Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9\'-hydroxy-3\',7\'-dimethylnona-1\',3\',5\',7\'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation.','2013-10-27','NSRP'),(12915,19842,'vitamin binding','F','Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.','2013-10-27','NSRP'),(12916,19843,'rRNA binding','F','Interacting selectively and non-covalently with ribosomal RNA.','2013-10-27','NSRP'),(12917,19844,'endotoxin activity','F','OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell.','2013-10-27','NSRP'),(12918,19845,'exotoxin activity','F','OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium.','2013-10-27','NSRP'),(12919,19846,'enterotoxin activity','F','OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms.','2013-10-27','NSRP'),(12920,19847,'neurotoxin activity','F','OBSOLETE. Acts to inhibit neural function in another living organism.','2013-10-27','NSRP'),(12921,19848,'conotoxin activity','F','OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species.','2013-10-27','NSRP'),(12922,19849,'cytotoxin activity','F','OBSOLETE. Acts as to cause injury to other living cells.','2013-10-27','NSRP'),(12923,19852,'L-ascorbic acid metabolic process','P','The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.','2013-10-27','NSRP'),(12924,19853,'L-ascorbic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.','2013-10-27','NSRP'),(12925,19854,'L-ascorbic acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.','2013-10-27','NSRP'),(12926,19855,'calcium channel inhibitor activity','F','Stops, prevents, or reduces the activity of a calcium channel.','2013-10-27','NSRP'),(12927,19856,'pyrimidine nucleobase biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases.','2013-10-27','NSRP'),(12928,19857,'5-methylcytosine metabolic process','P','The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA.','2013-10-27','NSRP'),(12929,19858,'cytosine metabolic process','P','The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives.','2013-10-27','NSRP'),(12930,19859,'thymine metabolic process','P','The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base.','2013-10-27','NSRP'),(12931,19860,'uracil metabolic process','P','The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.','2013-10-27','NSRP'),(12932,19861,'flagellum','C','OBSOLETE. Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium.','2013-10-27','NSRP'),(12933,19862,'IgA binding','F','Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype.','2013-10-27','NSRP'),(12934,19863,'IgE binding','F','Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype.','2013-10-27','NSRP'),(12935,19864,'IgG binding','F','Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype.','2013-10-27','NSRP'),(12936,19865,'immunoglobulin binding','F','Interacting selectively and non-covalently with an immunoglobulin.','2013-10-27','NSRP'),(12937,19866,'organelle inner membrane','C','The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites.','2013-10-27','NSRP'),(12938,19867,'outer membrane','C','The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.','2013-10-27','NSRP'),(12939,19869,'chloride channel inhibitor activity','F','Stops, prevents, or reduces the activity of a chloride channel.','2013-10-27','NSRP'),(12940,19870,'potassium channel inhibitor activity','F','Stops, prevents, or reduces the activity of a potassium channel.','2013-10-27','NSRP'),(12941,19871,'sodium channel inhibitor activity','F','Stops, prevents, or reduces the activity of a sodium channel.','2013-10-27','NSRP'),(12942,19872,'streptomycin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome.','2013-10-27','NSRP'),(12943,19873,'tellurium sensitivity/resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12944,19874,'6-aminohexanoate-cyclic-dimer hydrolase activity','F','Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H(2)O = N-(6-aminohexanoyl)-6-aminohexanoate.','2013-10-27','NSRP'),(12945,19875,'6-aminohexanoate-dimer hydrolase activity','F','Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate.','2013-10-27','NSRP'),(12946,19876,'nylon catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids.','2013-10-27','NSRP'),(12947,19877,'diaminopimelate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls.','2013-10-27','NSRP'),(12948,19878,'lysine biosynthetic process via aminoadipic acid','P','The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway.','2013-10-27','NSRP'),(12949,19879,'peptidyl-thyronine biosynthetic process from peptidyl-tyrosine','P','The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine.','2013-10-27','NSRP'),(12950,19880,'bacteriocin susceptibility/resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12951,19881,'streptomycin susceptibility/resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12952,19882,'antigen processing and presentation','P','The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(12953,19883,'antigen processing and presentation of endogenous antigen','P','The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(12954,19884,'antigen processing and presentation of exogenous antigen','P','The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(12955,19885,'antigen processing and presentation of endogenous peptide antigen via MHC class I','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(12956,19886,'antigen processing and presentation of exogenous peptide antigen via MHC class II','P','The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.','2013-10-27','NSRP'),(12957,19887,'protein kinase regulator activity','F','Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein.','2013-10-27','NSRP'),(12958,19888,'protein phosphatase regulator activity','F','Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule.','2013-10-27','NSRP'),(12959,19889,'pteridine metabolic process','P','The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group.','2013-10-27','NSRP'),(12960,19893,'DNA replication inhibitor','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(12961,19894,'kinesin binding','F','Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.','2013-10-27','NSRP'),(12962,19895,'kinesin-associated mitochondrial adaptor activity','F','The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria.','2013-10-27','NSRP'),(12963,19896,'axon transport of mitochondrion','P','The directed movement of mitochondria along microtubules in nerve cell axons.','2013-10-27','NSRP'),(12964,19897,'extrinsic to plasma membrane','C','Loosely bound to one surface of the plasma membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(12965,19898,'extrinsic to membrane','C','Loosely bound to one surface of a membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(12966,19899,'enzyme binding','F','Interacting selectively and non-covalently with any enzyme.','2013-10-27','NSRP'),(12967,19900,'kinase binding','F','Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.','2013-10-27','NSRP'),(12968,19901,'protein kinase binding','F','Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.','2013-10-27','NSRP'),(12969,19902,'phosphatase binding','F','Interacting selectively and non-covalently with any phosphatase.','2013-10-27','NSRP'),(12970,19903,'protein phosphatase binding','F','Interacting selectively and non-covalently with any protein phosphatase.','2013-10-27','NSRP'),(12971,19904,'protein domain specific binding','F','Interacting selectively and non-covalently with a specific domain of a protein.','2013-10-27','NSRP'),(12972,19905,'syntaxin binding','F','Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse.','2013-10-27','NSRP'),(12973,19907,'cyclin-dependent protein kinase activating kinase holoenzyme complex','C','A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.','2013-10-27','NSRP'),(12974,19908,'nuclear cyclin-dependent protein kinase holoenzyme complex','C','Cyclin-dependent protein kinase (CDK) complex found in the nucleus.','2013-10-27','NSRP'),(12975,19909,'[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity','F','Modification of the activity of the enzyme [pyruvate dehydrogenase (lipoamide)] phosphatase.','2013-10-27','NSRP'),(12976,19910,'mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex','C','A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus.','2013-10-27','NSRP'),(12977,19911,'structural constituent of myelin sheath','F','The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve.','2013-10-27','NSRP'),(12978,19912,'cyclin-dependent protein kinase activating kinase activity','F','Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK).','2013-10-27','NSRP'),(12979,19914,'cyclin-dependent protein kinase activating kinase regulator activity','F','Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase.','2013-10-27','NSRP'),(12980,19915,'lipid storage','P','The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.','2013-10-27','NSRP'),(12981,19916,'peptidyl-D-alanine racemization, direct','P','The racemization of peptidyl-alanine.','2013-10-27','NSRP'),(12982,19917,'peptidyl-D-alanine racemization via peptidyl-L-serine','P','The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine.','2013-10-27','NSRP'),(12983,19918,'peptidyl-arginine methylation, to symmetrical-dimethyl arginine','P','The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N\'(omega)-dimethyl-L-arginine.','2013-10-27','NSRP'),(12984,19919,'peptidyl-arginine methylation, to asymmetrical-dimethyl arginine','P','The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine.','2013-10-27','NSRP'),(12985,19920,'peptidyl-1-thioglycine biosynthetic process, internal','P','The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide.','2013-10-27','NSRP'),(12986,19921,'peptidyl-1-thioglycine biosynthetic process, carboxy-terminal','P','The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond.','2013-10-27','NSRP'),(12987,19922,'protein-chromophore linkage via peptidyl-cysteine','P','The covalent linking of a chromophore to a protein via peptidyl-cysteines.','2013-10-27','NSRP'),(12988,19923,'alpha-1-microglobulin-chromophore linkage','P','The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds.','2013-10-27','NSRP'),(12989,19926,'peptidyl-tryptophan oxidation to tryptophyl quinone','P','The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine.','2013-10-27','NSRP'),(12990,19927,'peptide cross-linking via 4\'-(S-L-cysteinyl)-L-tryptophyl quinone','P','The cross-linking of a cysteine residue to tryptophyl quinone to form 4\'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase.','2013-10-27','NSRP'),(12991,19928,'peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid','P','The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid.','2013-10-27','NSRP'),(12992,19929,'peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid','P','The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid.','2013-10-27','NSRP'),(12993,19930,'cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid','P','The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1.','2013-10-27','NSRP'),(12994,19931,'protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine','P','The modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine.','2013-10-27','NSRP'),(12995,19932,'second-messenger-mediated signaling','P','Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.','2013-10-27','NSRP'),(12996,19933,'cAMP-mediated signaling','P','Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell.','2013-10-27','NSRP'),(12997,19934,'cGMP-mediated signaling','P','Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.','2013-10-27','NSRP'),(12998,19935,'cyclic-nucleotide-mediated signaling','P','Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell.','2013-10-27','NSRP'),(12999,19936,'inositol phospholipid-mediated signaling','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13000,19937,'protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic','P','The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid.','2013-10-27','NSRP'),(13001,19938,'peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic','P','The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions.','2013-10-27','NSRP'),(13002,19939,'peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine','P','The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically.','2013-10-27','NSRP'),(13003,19940,'SUMO-dependent protein catabolic process','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13004,19941,'modification-dependent protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein.','2013-10-27','NSRP'),(13005,19942,'NEDD8 class-dependent protein catabolic process','P','OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein.','2013-10-27','NSRP'),(13006,19948,'SUMO activating enzyme activity','F','Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.','2013-10-27','NSRP'),(13007,19950,'SMT3-dependent protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein.','2013-10-27','NSRP'),(13008,19951,'Smt3-protein conjugation','P','The covalent addition to a protein of Smt3, a ubiquitin-like protein.','2013-10-27','NSRP'),(13009,19953,'sexual reproduction','P','The regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times.','2013-10-27','NSRP'),(13010,19954,'asexual reproduction','P','The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process.','2013-10-27','NSRP'),(13011,19955,'cytokine binding','F','Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.','2013-10-27','NSRP'),(13012,19956,'chemokine binding','F','Interacting selectively and non-covalently with a chemokine, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.','2013-10-27','NSRP'),(13013,19957,'C-C chemokine binding','F','Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.','2013-10-27','NSRP'),(13014,19958,'C-X-C chemokine binding','F','Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif.','2013-10-27','NSRP'),(13015,19959,'interleukin-8 binding','F','Interacting selectively and non-covalently with interleukin-8.','2013-10-27','NSRP'),(13016,19960,'C-X3-C chemokine binding','F','Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif.','2013-10-27','NSRP'),(13017,19961,'interferon binding','F','Interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent.','2013-10-27','NSRP'),(13018,19962,'type I interferon binding','F','Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.','2013-10-27','NSRP'),(13019,19964,'interferon-gamma binding','F','Interacting selectively and non-covalently with interferon-gamma. Interferon-gamma is also known as type II interferon.','2013-10-27','NSRP'),(13020,19966,'interleukin-1 binding','F','Interacting selectively and non-covalently with interleukin-1.','2013-10-27','NSRP'),(13021,19969,'interleukin-10 binding','F','Interacting selectively and non-covalently with interleukin-10.','2013-10-27','NSRP'),(13022,19970,'interleukin-11 binding','F','Interacting selectively and non-covalently with interleukin-11.','2013-10-27','NSRP'),(13023,19972,'interleukin-12 binding','F','Interacting selectively and non-covalently with interleukin-12.','2013-10-27','NSRP'),(13024,19973,'interleukin-13 binding','F','Interacting selectively and non-covalently with interleukin-13.','2013-10-27','NSRP'),(13025,19974,'interleukin-14 binding','F','Interacting selectively and non-covalently with interleukin-14.','2013-10-27','NSRP'),(13026,19975,'interleukin-17 binding','F','Interacting selectively and non-covalently with any member of the interleukin-17 family of cytokines.','2013-10-27','NSRP'),(13027,19976,'interleukin-2 binding','F','Interacting selectively and non-covalently with interleukin-2.','2013-10-27','NSRP'),(13028,19977,'interleukin-21 binding','F','Interacting selectively and non-covalently with interleukin-21.','2013-10-27','NSRP'),(13029,19978,'interleukin-3 binding','F','Interacting selectively and non-covalently with interleukin-3.','2013-10-27','NSRP'),(13030,19979,'interleukin-4 binding','F','Interacting selectively and non-covalently with interleukin-4.','2013-10-27','NSRP'),(13031,19980,'interleukin-5 binding','F','Interacting selectively and non-covalently with interleukin-5.','2013-10-27','NSRP'),(13032,19981,'interleukin-6 binding','F','Interacting selectively and non-covalently with interleukin-6.','2013-10-27','NSRP'),(13033,19982,'interleukin-7 binding','F','Interacting selectively and non-covalently with interleukin-7.','2013-10-27','NSRP'),(13034,19983,'interleukin-9 binding','F','Interacting selectively and non-covalently with interleukin-9.','2013-10-27','NSRP'),(13035,19985,'translesion synthesis','P','The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide.','2013-10-27','NSRP'),(13036,19987,'negative regulation of anti-apoptosis','P','OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis.','2013-10-27','NSRP'),(13037,19988,'charged-tRNA amino acid modification','P','The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine.','2013-10-27','NSRP'),(13038,19990,'pteridine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group.','2013-10-27','NSRP'),(13039,19991,'septate junction assembly','P','The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space.','2013-10-27','NSRP'),(13040,19992,'diacylglycerol binding','F','Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids.','2013-10-27','NSRP'),(13041,20002,'host cell plasma membrane','C','The plasma membrane surrounding a host cell.','2013-10-27','NSRP'),(13042,20003,'symbiont-containing vacuole','C','Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont.','2013-10-27','NSRP'),(13043,20004,'symbiont-containing vacuolar space','C','The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane.','2013-10-27','NSRP'),(13044,20005,'symbiont-containing vacuole membrane','C','The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont.','2013-10-27','NSRP'),(13045,20006,'symbiont-containing vacuolar membrane network','C','Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm.','2013-10-27','NSRP'),(13046,20007,'apical complex','C','A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation.','2013-10-27','NSRP'),(13047,20008,'rhoptry','C','A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole.','2013-10-27','NSRP'),(13048,20009,'microneme','C','A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite\'s apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell.','2013-10-27','NSRP'),(13049,20010,'conoid','C','A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules.','2013-10-27','NSRP'),(13050,20011,'apicoplast','C','The plastid organelle found in apicomplexans.','2013-10-27','NSRP'),(13051,20012,'evasion or tolerance of host immune response','P','Any process, either active or passive, by which an organism avoids the effects of the host organism\'s immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(13052,20013,'modulation by symbiont of host erythrocyte aggregation','P','Any process in which a symbiont organism modulates the frequency, rate or extent of erythrocyte aggregation in its host organism, e.g. the binding of parasite-infected erythrocytes to uninfected erythrocytes.','2013-10-27','NSRP'),(13053,20014,'schizogony','P','Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously.','2013-10-27','NSRP'),(13054,20015,'glycosome','C','A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.','2013-10-27','NSRP'),(13055,20016,'flagellar pocket','C','Invagination of the plasma membrane from which a flagellum protrudes.','2013-10-27','NSRP'),(13056,20017,'flagellar membrane','C','The portion of the plasma membrane surrounding the flagellum.','2012-03-14','NSRP'),(13057,20018,'flagellar pocket membrane','C','That part of the plasma membrane found in the flagellar pocket.','2013-10-27','NSRP'),(13058,20020,'food vacuole','C','Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa.','2013-10-27','NSRP'),(13059,20021,'immortalization of host cell','P','The modification of a host cell into an immortal cell line as a consequence of infection. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(13060,20022,'acidocalcisome','C','An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations.','2013-10-27','NSRP'),(13061,20023,'kinetoplast','C','A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum.','2013-10-27','NSRP'),(13062,20025,'subpellicular microtubule','C','Singlet microtubules that lie underneath the inner membrane complex and emanate from the basal ring of the conoid.','2013-10-27','NSRP'),(13063,20026,'merozoite dense granule','C','Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell.','2013-10-27','NSRP'),(13064,20027,'hemoglobin metabolic process','P','The chemical reactions and pathways involving hemoglobin, including its uptake and utilization.','2013-10-27','NSRP'),(13065,20028,'hemoglobin import','P','The directed movement into a tissue, cell or organelle of externally available hemoglobin.','2013-10-27','NSRP'),(13066,20030,'infected host cell surface knob','C','Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species.','2013-10-27','NSRP'),(13067,20031,'polar ring of apical complex','C','An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite.','2013-10-27','NSRP'),(13068,20032,'basal ring of apical complex','C','An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite.','2013-10-27','NSRP'),(13069,20033,'antigenic variation','P','Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism\'s immune system.','2013-10-27','NSRP'),(13070,20035,'cytoadherence to microvasculature, mediated by symbiont protein','P','The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte.','2013-10-27','NSRP'),(13071,20036,'Maurer\'s cleft','C','A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton.','2013-10-27','NSRP'),(13072,20037,'heme binding','F','Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.','2013-10-27','NSRP'),(13073,20038,'subpellicular network','C','A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton.','2013-10-27','NSRP'),(13074,20039,'pellicle','C','The structure enclosing an apicomplexan parasite cell; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles.','2013-10-27','NSRP'),(13075,21501,'prechordal plate formation','P','The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann\'s organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells.','2013-10-27','NSRP'),(13076,21502,'neural fold elevation formation','P','The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm.','2013-10-27','NSRP'),(13077,21503,'neural fold bending','P','The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse.','2013-10-27','NSRP'),(13078,21504,'neural fold hinge point formation','P','The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube.','2013-10-27','NSRP'),(13079,21505,'neural fold folding','P','The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds.','2013-10-27','NSRP'),(13080,21506,'anterior neuropore closure','P','The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete.','2013-10-27','NSRP'),(13081,21507,'posterior neuropore closure','P','The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete.','2013-10-27','NSRP'),(13082,21508,'floor plate formation','P','The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage.','2013-10-27','NSRP'),(13083,21509,'roof plate formation','P','The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells.','2013-10-27','NSRP'),(13084,21510,'spinal cord development','P','The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.','2013-10-27','NSRP'),(13085,21511,'spinal cord patterning','P','The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord.','2013-10-27','NSRP'),(13086,21512,'spinal cord anterior/posterior patterning','P','The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord.','2013-10-27','NSRP'),(13087,21513,'spinal cord dorsal/ventral patterning','P','The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord.','2013-10-27','NSRP'),(13088,21514,'ventral spinal cord interneuron differentiation','P','The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13089,21515,'cell differentiation in spinal cord','P','The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13090,21516,'dorsal spinal cord development','P','The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input.','2013-10-27','NSRP'),(13091,21517,'ventral spinal cord development','P','The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output.','2013-10-27','NSRP'),(13092,21518,'spinal cord commissural neuron specification','P','The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway.','2013-10-27','NSRP'),(13093,21519,'spinal cord association neuron specification','P','The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway.','2013-10-27','NSRP'),(13094,21520,'spinal cord motor neuron cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.','2013-10-27','NSRP'),(13095,21521,'ventral spinal cord interneuron specification','P','The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway.','2013-10-27','NSRP'),(13096,21522,'spinal cord motor neuron differentiation','P','The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13097,21523,'somatic motor neuron differentiation','P','The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13098,21524,'visceral motor neuron differentiation','P','The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13099,21525,'lateral motor column neuron differentiation','P','The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13100,21526,'medial motor column neuron differentiation','P','The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13101,21527,'spinal cord association neuron differentiation','P','The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13102,21528,'commissural neuron differentiation in spinal cord','P','The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13103,21529,'spinal cord oligodendrocyte cell differentiation','P','The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13104,21530,'spinal cord oligodendrocyte cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway.','2013-10-27','NSRP'),(13105,21531,'spinal cord radial glial cell differentiation','P','The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13106,21532,'neural tube patterning','P','The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube.','2013-10-27','NSRP'),(13107,21533,'cell differentiation in hindbrain','P','The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13108,21534,'cell proliferation in hindbrain','P','The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain.','2013-10-27','NSRP'),(13109,21535,'cell migration in hindbrain','P','The orderly movement of a cell that will reside in the hindbrain.','2013-10-27','NSRP'),(13110,21536,'diencephalon development','P','The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.','2013-10-27','NSRP'),(13111,21537,'telencephalon development','P','The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived.','2013-10-27','NSRP'),(13112,21538,'epithalamus development','P','The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle.','2013-10-27','NSRP'),(13113,21539,'subthalamus development','P','The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis.','2013-10-27','NSRP'),(13114,21540,'corpus callosum morphogenesis','P','The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres.','2013-10-27','NSRP'),(13115,21541,'ammon gyrus development','P','The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons.','2013-10-27','NSRP'),(13116,21542,'dentate gyrus development','P','The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus.','2013-10-27','NSRP'),(13117,21543,'pallium development','P','The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon.','2013-10-27','NSRP'),(13118,21544,'subpallium development','P','The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon.','2013-10-27','NSRP'),(13119,21545,'cranial nerve development','P','The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.','2013-10-27','NSRP'),(13120,21546,'rhombomere development','P','The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.','2013-10-27','NSRP'),(13121,21547,'midbrain-hindbrain boundary initiation','P','The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.','2013-10-27','NSRP'),(13122,21548,'pons development','P','The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.','2013-10-27','NSRP'),(13123,21549,'cerebellum development','P','The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.','2013-10-27','NSRP'),(13124,21550,'medulla oblongata development','P','The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.','2013-10-27','NSRP'),(13125,21551,'central nervous system morphogenesis','P','The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.','2013-10-27','NSRP'),(13126,21552,'midbrain-hindbrain boundary structural organization','P','The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.','2013-10-27','NSRP'),(13127,21553,'olfactory nerve development','P','The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.','2013-10-27','NSRP'),(13128,21554,'optic nerve development','P','The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.','2013-10-27','NSRP'),(13129,21555,'midbrain-hindbrain boundary morphogenesis','P','The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.','2013-10-27','NSRP'),(13130,21556,'central nervous system formation','P','The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.','2013-10-27','NSRP'),(13131,21557,'oculomotor nerve development','P','The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.','2013-10-27','NSRP'),(13132,21558,'trochlear nerve development','P','The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.','2013-10-27','NSRP'),(13133,21559,'trigeminal nerve development','P','The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.','2013-10-27','NSRP'),(13134,21560,'abducens nerve development','P','The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.','2013-10-27','NSRP'),(13135,21561,'facial nerve development','P','The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.','2013-10-27','NSRP'),(13136,21562,'vestibulocochlear nerve development','P','The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.','2013-10-27','NSRP'),(13137,21563,'glossopharyngeal nerve development','P','Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.','2013-10-27','NSRP'),(13138,21564,'vagus nerve development','P','The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.','2013-10-27','NSRP'),(13139,21565,'accessory nerve development','P','The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.','2013-10-27','NSRP'),(13140,21566,'hypoglossal nerve development','P','The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.','2013-10-27','NSRP'),(13141,21567,'rhombomere 1 development','P','The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13142,21568,'rhombomere 2 development','P','The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13143,21569,'rhombomere 3 development','P','The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13144,21570,'rhombomere 4 development','P','The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13145,21571,'rhombomere 5 development','P','The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13146,21572,'rhombomere 6 development','P','The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13147,21573,'rhombomere 7 development','P','The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13148,21574,'rhombomere 8 development','P','The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13149,21575,'hindbrain morphogenesis','P','The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.','2013-10-27','NSRP'),(13150,21576,'hindbrain formation','P','The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.','2013-10-27','NSRP'),(13151,21577,'hindbrain structural organization','P','The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.','2013-10-27','NSRP'),(13152,21578,'hindbrain maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions.','2013-10-27','NSRP'),(13153,21579,'medulla oblongata morphogenesis','P','The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.','2013-10-27','NSRP'),(13154,21580,'medulla oblongata formation','P','The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.','2013-10-27','NSRP'),(13155,21581,'medulla oblongata structural organization','P','The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.','2013-10-27','NSRP'),(13156,21582,'medulla oblongata maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate.','2013-10-27','NSRP'),(13157,21583,'pons morphogenesis','P','The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.','2013-10-27','NSRP'),(13158,21584,'pons formation','P','The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.','2013-10-27','NSRP'),(13159,21585,'pons structural organization','P','The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.','2013-10-27','NSRP'),(13160,21586,'pons maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum.','2013-10-27','NSRP'),(13161,21587,'cerebellum morphogenesis','P','The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.','2013-10-27','NSRP'),(13162,21588,'cerebellum formation','P','The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.','2013-10-27','NSRP'),(13163,21589,'cerebellum structural organization','P','The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.','2013-10-27','NSRP'),(13164,21590,'cerebellum maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills.','2013-10-27','NSRP'),(13165,21591,'ventricular system development','P','The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus.','2013-10-27','NSRP'),(13166,21592,'fourth ventricle development','P','The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space.','2013-10-27','NSRP'),(13167,21593,'rhombomere morphogenesis','P','The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.','2013-10-27','NSRP'),(13168,21594,'rhombomere formation','P','The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.','2013-10-27','NSRP'),(13169,21595,'rhombomere structural organization','P','The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates.','2013-10-27','NSRP'),(13170,21597,'central nervous system structural organization','P','The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.','2013-10-27','NSRP'),(13171,21598,'abducens nerve morphogenesis','P','The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.','2013-10-27','NSRP'),(13172,21599,'abducens nerve formation','P','The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.','2013-10-27','NSRP'),(13173,21600,'abducens nerve structural organization','P','The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.','2013-10-27','NSRP'),(13174,21601,'abducens nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.','2013-10-27','NSRP'),(13175,21602,'cranial nerve morphogenesis','P','The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.','2013-10-27','NSRP'),(13176,21603,'cranial nerve formation','P','The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.','2013-10-27','NSRP'),(13177,21604,'cranial nerve structural organization','P','The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.','2013-10-27','NSRP'),(13178,21605,'cranial nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.','2013-10-27','NSRP'),(13179,21606,'accessory nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.','2013-10-27','NSRP'),(13180,21607,'accessory nerve morphogenesis','P','The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.','2013-10-27','NSRP'),(13181,21608,'accessory nerve formation','P','The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.','2013-10-27','NSRP'),(13182,21609,'accessory nerve structural organization','P','The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve.','2013-10-27','NSRP'),(13183,21610,'facial nerve morphogenesis','P','The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.','2013-10-27','NSRP'),(13184,21611,'facial nerve formation','P','The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.','2013-10-27','NSRP'),(13185,21612,'facial nerve structural organization','P','The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.','2013-10-27','NSRP'),(13186,21613,'facial nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.','2013-10-27','NSRP'),(13187,21614,'glossopharyngeal nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.','2013-10-27','NSRP'),(13188,21615,'glossopharyngeal nerve morphogenesis','P','The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.','2013-10-27','NSRP'),(13189,21616,'glossopharyngeal nerve formation','P','The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.','2013-10-27','NSRP'),(13190,21617,'glossopharyngeal nerve structural organization','P','The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.','2013-10-27','NSRP'),(13191,21618,'hypoglossal nerve morphogenesis','P','The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.','2013-10-27','NSRP'),(13192,21619,'hypoglossal nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.','2013-10-27','NSRP'),(13193,21620,'hypoglossal nerve formation','P','The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.','2013-10-27','NSRP'),(13194,21621,'hypoglossal nerve structural organization','P','The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue.','2013-10-27','NSRP'),(13195,21622,'oculomotor nerve morphogenesis','P','The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.','2013-10-27','NSRP'),(13196,21623,'oculomotor nerve formation','P','The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.','2013-10-27','NSRP'),(13197,21624,'oculomotor nerve structural organization','P','The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.','2013-10-27','NSRP'),(13198,21625,'oculomotor nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.','2013-10-27','NSRP'),(13199,21626,'central nervous system maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.','2013-10-27','NSRP'),(13200,21627,'olfactory nerve morphogenesis','P','The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.','2013-10-27','NSRP'),(13201,21628,'olfactory nerve formation','P','The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.','2013-10-27','NSRP'),(13202,21629,'olfactory nerve structural organization','P','The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.','2013-10-27','NSRP'),(13203,21630,'olfactory nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem.','2013-10-27','NSRP'),(13204,21631,'optic nerve morphogenesis','P','The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.','2013-10-27','NSRP'),(13205,21632,'optic nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.','2013-10-27','NSRP'),(13206,21633,'optic nerve structural organization','P','The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.','2013-10-27','NSRP'),(13207,21634,'optic nerve formation','P','The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain.','2013-10-27','NSRP'),(13208,21635,'trigeminal nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.','2013-10-27','NSRP'),(13209,21636,'trigeminal nerve morphogenesis','P','The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.','2013-10-27','NSRP'),(13210,21637,'trigeminal nerve structural organization','P','The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.','2013-10-27','NSRP'),(13211,21638,'trigeminal nerve formation','P','The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae.','2013-10-27','NSRP'),(13212,21639,'trochlear nerve morphogenesis','P','The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.','2013-10-27','NSRP'),(13213,21640,'trochlear nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.','2013-10-27','NSRP'),(13214,21641,'trochlear nerve structural organization','P','The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.','2013-10-27','NSRP'),(13215,21642,'trochlear nerve formation','P','The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle.','2013-10-27','NSRP'),(13216,21643,'vagus nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.','2013-10-27','NSRP'),(13217,21644,'vagus nerve morphogenesis','P','The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.','2013-10-27','NSRP'),(13218,21645,'vagus nerve structural organization','P','The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.','2013-10-27','NSRP'),(13219,21646,'vagus nerve formation','P','The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis.','2013-10-27','NSRP'),(13220,21647,'vestibulocochlear nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.','2013-10-27','NSRP'),(13221,21648,'vestibulocochlear nerve morphogenesis','P','The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.','2013-10-27','NSRP'),(13222,21649,'vestibulocochlear nerve structural organization','P','The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.','2013-10-27','NSRP'),(13223,21650,'vestibulocochlear nerve formation','P','The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.','2013-10-27','NSRP'),(13224,21651,'rhombomere 1 morphogenesis','P','The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13225,21652,'rhombomere 1 formation','P','The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13226,21653,'rhombomere 1 structural organization','P','The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13227,21654,'rhombomere boundary formation','P','The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13228,21655,'rhombomere 2 morphogenesis','P','The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13229,21656,'rhombomere 2 structural organization','P','The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13230,21657,'rhombomere 2 formation','P','The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13231,21658,'rhombomere 3 morphogenesis','P','The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13232,21659,'rhombomere 3 structural organization','P','The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13233,21660,'rhombomere 3 formation','P','The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13234,21661,'rhombomere 4 morphogenesis','P','The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13235,21662,'rhombomere 4 structural organization','P','The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13236,21663,'rhombomere 4 formation','P','The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13237,21664,'rhombomere 5 morphogenesis','P','The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13238,21665,'rhombomere 5 structural organization','P','The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13239,21666,'rhombomere 5 formation','P','The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13240,21667,'rhombomere 6 morphogenesis','P','The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13241,21668,'rhombomere 6 structural organization','P','The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13242,21669,'rhombomere 6 formation','P','The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13243,21670,'lateral ventricle development','P','The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle.','2013-10-27','NSRP'),(13244,21671,'rhombomere 7 morphogenesis','P','The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13245,21672,'rhombomere 7 structural organization','P','The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13246,21673,'rhombomere 7 formation','P','The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13247,21674,'rhombomere 8 morphogenesis','P','The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13248,21675,'nerve development','P','The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13249,21676,'rhombomere 8 structural organization','P','The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order.','2013-10-27','NSRP'),(13250,21677,'rhombomere 8 formation','P','The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.','2013-10-27','NSRP'),(13251,21678,'third ventricle development','P','The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina.','2013-10-27','NSRP'),(13252,21679,'cerebellar molecular layer development','P','The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.','2013-10-27','NSRP'),(13253,21680,'cerebellar Purkinje cell layer development','P','The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.','2013-10-27','NSRP'),(13254,21681,'cerebellar granular layer development','P','The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.','2013-10-27','NSRP'),(13255,21682,'nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state.','2013-10-27','NSRP'),(13256,21683,'cerebellar granular layer morphogenesis','P','The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.','2013-10-27','NSRP'),(13257,21684,'cerebellar granular layer formation','P','The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.','2013-10-27','NSRP'),(13258,21685,'cerebellar granular layer structural organization','P','The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.','2013-10-27','NSRP'),(13259,21686,'cerebellar granular layer maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer.','2013-10-27','NSRP'),(13260,21687,'cerebellar molecular layer morphogenesis','P','The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.','2013-10-27','NSRP'),(13261,21688,'cerebellar molecular layer formation','P','The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.','2013-10-27','NSRP'),(13262,21689,'cerebellar molecular layer structural organization','P','The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.','2013-10-27','NSRP'),(13263,21690,'cerebellar molecular layer maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells.','2013-10-27','NSRP'),(13264,21691,'cerebellar Purkinje cell layer maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.','2013-10-27','NSRP'),(13265,21692,'cerebellar Purkinje cell layer morphogenesis','P','The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.','2013-10-27','NSRP'),(13266,21693,'cerebellar Purkinje cell layer structural organization','P','The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.','2013-10-27','NSRP'),(13267,21694,'cerebellar Purkinje cell layer formation','P','The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells.','2013-10-27','NSRP'),(13268,21695,'cerebellar cortex development','P','The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.','2013-10-27','NSRP'),(13269,21696,'cerebellar cortex morphogenesis','P','The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.','2013-10-27','NSRP'),(13270,21697,'cerebellar cortex formation','P','The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.','2013-10-27','NSRP'),(13271,21698,'cerebellar cortex structural organization','P','The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.','2013-10-27','NSRP'),(13272,21699,'cerebellar cortex maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.','2013-10-27','NSRP'),(13273,21700,'developmental maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state.','2013-10-27','NSRP'),(13274,21701,'cerebellar Golgi cell differentiation','P','The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13275,21702,'cerebellar Purkinje cell differentiation','P','The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.','2013-10-27','NSRP'),(13276,21703,'locus ceruleus development','P','The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.','2013-10-27','NSRP'),(13277,21704,'locus ceruleus morphogenesis','P','The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.','2013-10-27','NSRP'),(13278,21705,'locus ceruleus formation','P','The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.','2013-10-27','NSRP'),(13279,21706,'locus ceruleus maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.','2013-10-27','NSRP'),(13280,21707,'cerebellar granule cell differentiation','P','The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13281,21708,'Lugaro cell differentiation','P','The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13282,21709,'cerebellar basket cell differentiation','P','The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13283,21710,'cerebellar stellate cell differentiation','P','The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13284,21711,'cerebellar unipolar brush cell differentiation','P','The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13285,21712,'candelabrum cell differentiation','P','The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13286,21713,'inferior olivary nucleus development','P','The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.','2013-10-27','NSRP'),(13287,21714,'inferior olivary nucleus morphogenesis','P','The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.','2013-10-27','NSRP'),(13288,21715,'inferior olivary nucleus formation','P','The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.','2013-10-27','NSRP'),(13289,21716,'inferior olivary nucleus structural organization','P','The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.','2013-10-27','NSRP'),(13290,21717,'inferior olivary nucleus maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.','2013-10-27','NSRP'),(13291,21718,'superior olivary nucleus development','P','The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.','2013-10-27','NSRP'),(13292,21719,'superior olivary nucleus morphogenesis','P','The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.','2013-10-27','NSRP'),(13293,21720,'superior olivary nucleus formation','P','The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.','2013-10-27','NSRP'),(13294,21721,'superior olivary nucleus structural organization','P','The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.','2013-10-27','NSRP'),(13295,21722,'superior olivary nucleus maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound.','2013-10-27','NSRP'),(13296,21723,'medullary reticular formation development','P','The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata.','2013-10-27','NSRP'),(13297,21724,'inferior raphe nucleus development','P','The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13298,21725,'superior raphe nucleus development','P','The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13299,21726,'lateral reticular nucleus development','P','The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13300,21727,'intermediate reticular formation development','P','The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13301,21728,'inferior reticular formation development','P','The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13302,21729,'superior reticular formation development','P','The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13303,21730,'trigeminal sensory nucleus development','P','The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13304,21731,'trigeminal motor nucleus development','P','The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13305,21732,'midbrain-hindbrain boundary maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.','2013-10-27','NSRP'),(13306,21735,'dentate nucleus development','P','The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13307,21736,'globose nucleus development','P','The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13308,21737,'emboliform nucleus development','P','The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13309,21738,'fastigial nucleus development','P','The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13310,21739,'mesencephalic trigeminal nucleus development','P','The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13311,21740,'principal sensory nucleus of trigeminal nerve development','P','The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13312,21741,'spinal trigeminal nucleus development','P','The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13313,21742,'abducens nucleus development','P','The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13314,21743,'hypoglossal nucleus development','P','The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13315,21744,'dorsal motor nucleus of vagus nerve development','P','The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13316,21745,'nucleus ambiguus development','P','The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13317,21746,'solitary nucleus development','P','The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13318,21747,'cochlear nucleus development','P','The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13319,21748,'dorsal cochlear nucleus development','P','The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13320,21749,'ventral cochlear nucleus development','P','The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13321,21750,'vestibular nucleus development','P','The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13322,21751,'salivary nucleus development','P','The process whose specific outcome is the progression of the salivary nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13323,21752,'inferior salivary nucleus development','P','The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13324,21753,'superior salivary nucleus development','P','The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13325,21754,'facial nucleus development','P','The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13326,21755,'eurydendroid cell differentiation','P','The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts.','2013-10-27','NSRP'),(13327,21756,'striatum development','P','The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati.','2013-10-27','NSRP'),(13328,21757,'caudate nucleus development','P','The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain.','2013-10-27','NSRP'),(13329,21758,'putamen development','P','The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain.','2013-10-27','NSRP'),(13330,21759,'globus pallidus development','P','The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain.','2013-10-27','NSRP'),(13331,21761,'limbic system development','P','The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory.','2013-10-27','NSRP'),(13332,21762,'substantia nigra development','P','The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis).','2013-10-27','NSRP'),(13333,21763,'subthalamic nucleus development','P','The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function.','2013-10-27','NSRP'),(13334,21764,'amygdala development','P','The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure.','2013-10-27','NSRP'),(13335,21765,'cingulate gyrus development','P','The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum.','2013-10-27','NSRP'),(13336,21766,'hippocampus development','P','The progression of the hippocampus over time from its initial formation until its mature state.','2013-10-27','NSRP'),(13337,21767,'mammillary body development','P','The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei.','2013-10-27','NSRP'),(13338,21768,'nucleus accumbens development','P','The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia.','2013-10-27','NSRP'),(13339,21769,'orbitofrontal cortex development','P','The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe.','2013-10-27','NSRP'),(13340,21770,'parahippocampal gyrus development','P','The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex.','2013-10-27','NSRP'),(13341,21771,'lateral geniculate nucleus development','P','The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina.','2013-10-27','NSRP'),(13342,21772,'olfactory bulb development','P','The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex.','2013-10-27','NSRP'),(13343,21773,'striatal medium spiny neuron differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum.','2013-10-27','NSRP'),(13344,21774,'retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification','P','The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.','2013-10-27','NSRP'),(13345,21775,'smoothened signaling pathway involved in ventral spinal cord interneuron specification','P','The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate.','2013-10-27','NSRP'),(13346,21776,'smoothened signaling pathway involved in spinal cord motor neuron cell fate specification','P','The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.','2013-10-27','NSRP'),(13347,21777,'BMP signaling pathway involved in spinal cord association neuron specification','P','A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate.','2013-10-27','NSRP'),(13348,21778,'oligodendrocyte cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(13349,21779,'oligodendrocyte cell fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte.','2013-10-27','NSRP'),(13350,21780,'glial cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(13351,21781,'glial cell fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell.','2013-10-27','NSRP'),(13352,21782,'glial cell development','P','The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.','2013-10-27','NSRP'),(13353,21783,'preganglionic parasympathetic nervous system development','P','The process whose specific outcome is the progression of the preganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.','2013-10-27','NSRP'),(13354,21784,'postganglionic parasympathetic nervous system development','P','The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.','2013-10-27','NSRP'),(13355,21785,'branchiomotor neuron axon guidance','P','The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.','2013-10-27','NSRP'),(13356,21786,'branchiomotor neuron axon guidance in neural tube','P','The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.','2013-10-27','NSRP'),(13357,21787,'chemorepulsion of branchiomotor neuron axon in neural tube','P','The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.','2013-10-27','NSRP'),(13358,21788,'chemoattraction of branchiomotor neuron axon in neural tube','P','The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.','2013-10-27','NSRP'),(13359,21789,'branchiomotor neuron axon guidance in branchial arch mesenchyme','P','The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.','2013-10-27','NSRP'),(13360,21790,'chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme','P','The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.','2013-10-27','NSRP'),(13361,21791,'chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme','P','The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.','2013-10-27','NSRP'),(13362,21792,'chemoattraction of branchiomotor axon','P','The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.','2013-10-27','NSRP'),(13363,21793,'chemorepulsion of branchiomotor axon','P','The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx.','2013-10-27','NSRP'),(13364,21794,'thalamus development','P','The process in which the thalamus changes over time, from its initial formation to its mature state.','2013-10-27','NSRP'),(13365,21795,'cerebral cortex cell migration','P','The orderly movement of cells from one site to another in the cerebral cortex.','2013-10-27','NSRP'),(13366,21796,'cerebral cortex regionalization','P','The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops.','2013-10-27','NSRP'),(13367,21797,'forebrain anterior/posterior pattern specification','P','The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain.','2013-10-27','NSRP'),(13368,21798,'forebrain dorsal/ventral pattern formation','P','The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain.','2013-10-27','NSRP'),(13369,21799,'cerebral cortex radially oriented cell migration','P','The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.','2013-10-27','NSRP'),(13370,21800,'cerebral cortex tangential migration','P','The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.','2013-10-27','NSRP'),(13371,21801,'cerebral cortex radial glia guided migration','P','The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex.','2013-10-27','NSRP'),(13372,21802,'somal translocation','P','The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate.','2013-10-27','NSRP'),(13373,21803,'pial surface process extension','P','The extension of a long process to the pial surface as a cell leaves the ventricular zone.','2013-10-27','NSRP'),(13374,21804,'negative regulation of cell adhesion in ventricular zone','P','The process that results in the loss of attachments of a cell in the ventricular zone.','2013-10-27','NSRP'),(13375,21805,'cell movement involved in somal translocation','P','The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface.','2013-10-27','NSRP'),(13376,21806,'initiation of movement involved in cerebral cortex radial glia guided migration','P','The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex.','2013-10-27','NSRP'),(13377,21807,'motogenic signaling initiating cell movement in cerebral cortex','P','The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex.','2013-10-27','NSRP'),(13378,21808,'cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration','P','The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration.','2013-10-27','NSRP'),(13379,21809,'neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration','P','Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration.','2013-10-27','NSRP'),(13380,21810,'neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration','P','Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration.','2013-10-27','NSRP'),(13381,21811,'growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration','P','Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex.','2013-10-27','NSRP'),(13382,21812,'neuronal-glial interaction involved in cerebral cortex radial glia guided migration','P','The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.','2013-10-27','NSRP'),(13383,21813,'cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration','P','The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex.','2013-10-27','NSRP'),(13384,21814,'cell motility involved in cerebral cortex radial glia guided migration','P','The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration.','2013-10-27','NSRP'),(13385,21815,'modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration','P','Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration.','2013-10-27','NSRP'),(13386,21816,'extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration','P','The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells.','2013-10-27','NSRP'),(13387,21817,'nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration','P','The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration.','2013-10-27','NSRP'),(13388,21818,'modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration','P','The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.','2013-10-27','NSRP'),(13389,21819,'layer formation in cerebral cortex','P','The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex.','2013-10-27','NSRP'),(13390,21820,'extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration','P','The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells.','2013-10-27','NSRP'),(13391,21821,'negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination','P','The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration.','2013-10-27','NSRP'),(13392,21822,'negative regulation of cell motility involved in cerebral cortex radial glia guided migration','P','The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex.','2013-10-27','NSRP'),(13393,21823,'cerebral cortex tangential migration using cell-cell interactions','P','The process in which neurons interact with each other to promote migration along a tangential plane.','2013-10-27','NSRP'),(13394,21824,'cerebral cortex tangential migration using cell-axon interactions','P','The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons.','2013-10-27','NSRP'),(13395,21825,'substrate-dependent cerebral cortex tangential migration','P','The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions.','2013-10-27','NSRP'),(13396,21826,'substrate-independent telencephalic tangential migration','P','The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact.','2013-10-27','NSRP'),(13397,21827,'postnatal olfactory bulb interneuron migration','P','The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth.','2013-10-27','NSRP'),(13398,21828,'gonadotrophin-releasing hormone neuronal migration to the hypothalamus','P','The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus.','2013-10-27','NSRP'),(13399,21829,'oligodendrocyte cell migration from the subpallium to the cortex','P','The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development.','2013-10-27','NSRP'),(13400,21830,'interneuron migration from the subpallium to the cortex','P','The directed movement of interneurons from the subpallium to the cortex during forebrain development.','2013-10-27','NSRP'),(13401,21831,'embryonic olfactory bulb interneuron precursor migration','P','The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb.','2013-10-27','NSRP'),(13402,21832,'cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions','P','The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration.','2013-10-27','NSRP'),(13403,21833,'cell-matrix adhesion involved in tangential migration using cell-cell interactions','P','The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex.','2013-10-27','NSRP'),(13404,21834,'chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration','P','The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb.','2013-10-27','NSRP'),(13405,21835,'chemoattraction involved in embryonic olfactory bulb interneuron precursor migration','P','The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb.','2013-10-27','NSRP'),(13406,21836,'chemorepulsion involved in postnatal olfactory bulb interneuron migration','P','The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration.','2013-10-27','NSRP'),(13407,21837,'motogenic signaling involved in postnatal olfactory bulb interneuron migration','P','The signaling that results in the stimulation of cell movement in the rostral migratory stream.','2013-10-27','NSRP'),(13408,21838,'motogenic signaling involved in interneuron migration from the subpallium to the cortex','P','The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex.','2013-10-27','NSRP'),(13409,21839,'interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex','P','The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex.','2013-10-27','NSRP'),(13410,21840,'directional guidance of interneurons involved in migration from the subpallium to the cortex','P','The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex.','2013-10-27','NSRP'),(13411,21841,'chemoattraction involved in interneuron migration from the subpallium to the cortex','P','The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex.','2013-10-27','NSRP'),(13412,21842,'chemorepulsion involved in interneuron migration from the subpallium to the cortex','P','The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.','2013-10-27','NSRP'),(13413,21843,'substrate-independent telencephalic tangential interneuron migration','P','The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates.','2013-10-27','NSRP'),(13414,21844,'interneuron sorting involved in substrate-independent cerebral cortex tangential migration','P','The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures.','2013-10-27','NSRP'),(13415,21845,'neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration','P','The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner.','2013-10-27','NSRP'),(13416,21846,'cell proliferation in forebrain','P','The creation of greater cell numbers in the forebrain due to cell division of progenitor cells.','2013-10-27','NSRP'),(13417,21847,'ventricular zone neuroblast division','P','The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially.','2013-10-27','NSRP'),(13418,21848,'neuroblast division in subpallium','P','The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially.','2013-10-27','NSRP'),(13419,21849,'neuroblast division in subventricular zone','P','The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially.','2013-10-27','NSRP'),(13420,21850,'subpallium glioblast cell division','P','The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes.','2013-10-27','NSRP'),(13421,21851,'neuroblast division in dorsal lateral ganglionic eminence','P','The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb.','2013-10-27','NSRP'),(13422,21852,'pyramidal neuron migration','P','The migration of pyramidal a neuron precursor from the ventricular zone to the correct layer of the cerebral cortex.','2013-10-27','NSRP'),(13423,21853,'cerebral cortex GABAergic interneuron migration','P','The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.','2013-10-27','NSRP'),(13424,21854,'hypothalamus development','P','The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state.','2013-10-27','NSRP'),(13425,21855,'hypothalamus cell migration','P','The directed movement of a cell into the hypothalamus region of the forebrain.','2013-10-27','NSRP'),(13426,21856,'hypothalamic tangential migration using cell-axon interactions','P','The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons.','2013-10-27','NSRP'),(13427,21858,'GABAergic neuron differentiation in basal ganglia','P','The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron.','2013-10-27','NSRP'),(13428,21859,'pyramidal neuron differentiation','P','The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron.','2013-10-27','NSRP'),(13429,21860,'pyramidal neuron development','P','The progression of a pyramidal neuron from its initial formation to its mature state.','2013-10-27','NSRP'),(13430,21861,'forebrain radial glial cell differentiation','P','The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13431,21862,'early neuron differentiation in forebrain','P','The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13432,21863,'forebrain neuroblast differentiation','P','The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate.','2013-10-27','NSRP'),(13433,21864,'radial glial cell division in forebrain','P','The mitotic division of radial glial cells in the developing forebrain.','2013-10-27','NSRP'),(13434,21865,'symmetric radial glial cell division in forebrain','P','The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain.','2013-10-27','NSRP'),(13435,21866,'asymmetric radial glial cell division in forebrain','P','The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type.','2013-10-27','NSRP'),(13436,21867,'neuron-producing asymmetric radial glial cell division in forebrain','P','The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor.','2013-10-27','NSRP'),(13437,21868,'ventricular zone cell-producing asymmetric radial glial cell division in forebrain','P','The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell.','2013-10-27','NSRP'),(13438,21869,'forebrain ventricular zone progenitor cell division','P','The mitotic division of a basal progenitor giving rise to two neurons.','2013-10-27','NSRP'),(13439,21870,'Cajal-Retzius cell differentiation','P','The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene.','2013-10-27','NSRP'),(13440,21871,'forebrain regionalization','P','The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops.','2013-10-27','NSRP'),(13441,21872,'forebrain generation of neurons','P','The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons.','2013-10-27','NSRP'),(13442,21873,'forebrain neuroblast division','P','The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast.','2013-10-27','NSRP'),(13443,21874,'Wnt receptor signaling pathway involved in forebrain neuroblast division','P','The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.','2013-10-27','NSRP'),(13444,21875,'fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division','P','The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain.','2013-10-27','NSRP'),(13445,21876,'Notch signaling pathway involved in forebrain neuroblast division','P','The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain.','2013-10-27','NSRP'),(13446,21877,'forebrain neuron fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain.','2013-10-27','NSRP'),(13447,21878,'forebrain astrocyte fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain.','2013-10-27','NSRP'),(13448,21879,'forebrain neuron differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.','2013-10-27','NSRP'),(13449,21880,'Notch signaling pathway involved in forebrain neuron fate commitment','P','The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.','2013-10-27','NSRP'),(13450,21881,'Wnt receptor signaling pathway involved in forebrain neuron fate commitment','P','The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain.','2013-10-27','NSRP'),(13451,21882,'regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.','2013-10-27','NSRP'),(13452,21883,'cell cycle arrest of committed forebrain neuronal progenitor cell','P','The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain.','2013-10-27','NSRP'),(13453,21884,'forebrain neuron development','P','The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell.','2013-10-27','NSRP'),(13454,21885,'forebrain cell migration','P','The orderly movement of a cell from one site to another at least one of which is located in the forebrain.','2013-10-27','NSRP'),(13455,21886,'hypothalamus gonadotrophin-releasing hormone neuron differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter.','2013-10-27','NSRP'),(13456,21887,'hypothalamus gonadotrophin-releasing hormone neuron fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone.','2013-10-27','NSRP'),(13457,21888,'hypothalamus gonadotrophin-releasing hormone neuron development','P','The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell.','2013-10-27','NSRP'),(13458,21889,'olfactory bulb interneuron differentiation','P','The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb.','2013-10-27','NSRP'),(13459,21890,'olfactory bulb interneuron fate commitment','P','The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb.','2013-10-27','NSRP'),(13460,21891,'olfactory bulb interneuron development','P','The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell.','2013-10-27','NSRP'),(13461,21892,'cerebral cortex GABAergic interneuron differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex.','2013-10-27','NSRP'),(13462,21893,'cerebral cortex GABAergic interneuron fate commitment','P','The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex.','2013-10-27','NSRP'),(13463,21894,'cerebral cortex GABAergic interneuron development','P','The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell.','2013-10-27','NSRP'),(13464,21895,'cerebral cortex neuron differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex.','2013-10-27','NSRP'),(13465,21896,'forebrain astrocyte differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.','2013-10-27','NSRP'),(13466,21897,'forebrain astrocyte development','P','The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.','2013-10-27','NSRP'),(13467,21898,'commitment of multipotent stem cells to neuronal lineage in forebrain','P','The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain.','2013-10-27','NSRP'),(13468,21899,'fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment','P','The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.','2013-10-27','NSRP'),(13469,21900,'ventricular zone cell fate commitment','P','The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons.','2013-10-27','NSRP'),(13470,21901,'early neuron fate commitment in forebrain','P','The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain.','2013-10-27','NSRP'),(13471,21902,'commitment of neuronal cell to specific neuron type in forebrain','P','The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain.','2013-10-27','NSRP'),(13472,21903,'rostrocaudal neural tube patterning','P','The process in which the neural tube is divided into specific regions along the rostrocaudal axis.','2013-10-27','NSRP'),(13473,21904,'dorsal/ventral neural tube patterning','P','The process in which the neural tube is regionalized in the dorsoventral axis.','2013-10-27','NSRP'),(13474,21905,'forebrain-midbrain boundary formation','P','The process whose specific outcome is the creation of the forebrain-midbrain boundary.','2013-10-27','NSRP'),(13475,21906,'hindbrain-spinal cord boundary formation','P','The process whose specific outcome is the formation of the hindbrain-spinal cord boundary.','2013-10-27','NSRP'),(13476,21907,'fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation','P','The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.','2013-10-27','NSRP'),(13477,21908,'retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation','P','The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.','2013-10-27','NSRP'),(13478,21909,'regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.','2013-10-27','NSRP'),(13479,21910,'smoothened signaling pathway involved in ventral spinal cord patterning','P','The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.','2013-10-27','NSRP'),(13480,21911,'retinoic acid metabolic process in spinal cord anterior-posterior patterning','P','The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord.','2013-10-27','NSRP'),(13481,21912,'regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord.','2013-10-27','NSRP'),(13482,21913,'regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord.','2013-10-27','NSRP'),(13483,21914,'negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning','P','Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord.','2013-10-27','NSRP'),(13484,21915,'neural tube development','P','The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.','2013-10-27','NSRP'),(13485,21916,'inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors','P','Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis.','2013-10-27','NSRP'),(13486,21917,'somatic motor neuron fate commitment','P','The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons.','2013-10-27','NSRP'),(13487,21918,'regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis.','2013-10-27','NSRP'),(13488,21919,'BMP signaling pathway involved in spinal cord dorsal/ventral patterning','P','A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord.','2013-10-27','NSRP'),(13489,21920,'regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord.','2013-10-27','NSRP'),(13490,21921,'regulation of cell proliferation in dorsal spinal cord','P','The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord.','2013-10-27','NSRP'),(13491,21922,'Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord','P','The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division.','2013-10-27','NSRP'),(13492,21923,'cell proliferation in hindbrain ventricular zone','P','The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity.','2013-10-27','NSRP'),(13493,21924,'cell proliferation in external granule layer','P','The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere.','2013-10-27','NSRP'),(13494,21925,'cerebellar Purkinje cell precursor proliferation','P','The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem.','2013-10-27','NSRP'),(13495,21926,'Golgi cell precursor proliferation','P','The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13496,21927,'deep nuclear neuron precursor proliferation','P','The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons.','2013-10-27','NSRP'),(13497,21928,'basket cell precursor proliferation','P','The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13498,21929,'stellate cell precursor proliferation','P','The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13499,21930,'cerebellar granule cell precursor proliferation','P','The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex.','2013-10-27','NSRP'),(13500,21931,'rostral hindbrain neuronal precursor cell proliferation','P','The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus.','2013-10-27','NSRP'),(13501,21932,'hindbrain radial glia guided cell migration','P','The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain.','2013-10-27','NSRP'),(13502,21933,'radial glia guided migration of cerebellar granule cell','P','The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer.','2013-10-27','NSRP'),(13503,21934,'hindbrain tangential cell migration','P','The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration.','2013-10-27','NSRP'),(13504,21935,'cerebellar granule cell precursor tangential migration','P','The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium.','2013-10-27','NSRP'),(13505,21936,'regulation of cerebellar granule cell precursor proliferation','P','The process that modulates the frequency, rate or extent of granule cell precursor proliferation.','2013-10-27','NSRP'),(13506,21937,'cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation','P','The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation.','2013-10-27','NSRP'),(13507,21938,'smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation','P','The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells.','2013-10-27','NSRP'),(13508,21939,'extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation','P','The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation.','2013-10-27','NSRP'),(13509,21940,'positive regulation of cerebellar granule cell precursor proliferation','P','The process that activates or increases the rate or extent of granule cell precursor proliferation.','2013-10-27','NSRP'),(13510,21941,'negative regulation of cerebellar granule cell precursor proliferation','P','The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation.','2013-10-27','NSRP'),(13511,21942,'radial glia guided migration of Purkinje cell','P','The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer.','2013-10-27','NSRP'),(13512,21943,'formation of radial glial scaffolds','P','The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells.','2013-10-27','NSRP'),(13513,21944,'neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration','P','The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration.','2013-10-27','NSRP'),(13514,21945,'positive regulation of cerebellar granule cell migration by calcium','P','The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration.','2013-10-27','NSRP'),(13515,21946,'deep nuclear neuron cell migration','P','The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei.','2013-10-27','NSRP'),(13516,21947,'outward migration of deep nuclear neurons','P','The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate.','2013-10-27','NSRP'),(13517,21948,'inward migration of deep nuclear neurons','P','The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position.','2013-10-27','NSRP'),(13518,21949,'brainstem precerebellar neuron precursor migration','P','The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem.','2013-10-27','NSRP'),(13519,21950,'chemorepulsion involved in precerebellar neuron migration','P','The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration.','2013-10-27','NSRP'),(13520,21951,'chemoattraction involved in precerebellar neuron migration','P','The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration.','2013-10-27','NSRP'),(13521,21952,'central nervous system projection neuron axonogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region.','2013-10-27','NSRP'),(13522,21953,'central nervous system neuron differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system.','2013-10-27','NSRP'),(13523,21954,'central nervous system neuron development','P','The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.','2013-10-27','NSRP'),(13524,21955,'central nervous system neuron axonogenesis','P','Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.','2013-10-27','NSRP'),(13525,21956,'central nervous system interneuron axonogenesis','P','Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region.','2013-10-27','NSRP'),(13526,21957,'corticospinal tract morphogenesis','P','Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract.','2013-10-27','NSRP'),(13527,21958,'gracilis tract morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb.','2013-10-27','NSRP'),(13528,21959,'cuneatus tract morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb.','2013-10-27','NSRP'),(13529,21960,'anterior commissure morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum.','2013-10-27','NSRP'),(13530,21961,'posterior commissure morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon.','2013-10-27','NSRP'),(13531,21962,'vestibulospinal tract morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord.','2013-10-27','NSRP'),(13532,21963,'spinothalamic tract morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling.','2013-10-27','NSRP'),(13533,21964,'rubrospinal tract morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord.','2013-10-27','NSRP'),(13534,21965,'spinal cord ventral commissure morphogenesis','P','The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized.','2013-10-27','NSRP'),(13535,21966,'corticospinal neuron axon guidance','P','The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(13536,21967,'corticospinal neuron axon guidance through the cerebral cortex','P','The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(13537,21968,'corticospinal neuron axon guidance through the internal capsule','P','The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(13538,21969,'corticospinal neuron axon guidance through the cerebral peduncle','P','The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(13539,21970,'corticospinal neuron axon guidance through the basilar pons','P','The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(13540,21971,'corticospinal neuron axon guidance through the medullary pyramid','P','The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(13541,21972,'corticospinal neuron axon guidance through spinal cord','P','The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(13542,21973,'corticospinal neuron axon decussation','P','The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side.','2013-10-27','NSRP'),(13543,21974,'trigeminothalamic tract morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face.','2013-10-27','NSRP'),(13544,21975,'pons reticulospinal tract morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord.','2013-10-27','NSRP'),(13545,21976,'medulla reticulospinal tract morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord.','2013-10-27','NSRP'),(13546,21977,'tectospinal tract morphogenesis','P','Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord.','2013-10-27','NSRP'),(13547,21978,'telencephalon regionalization','P','The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops.','2013-10-27','NSRP'),(13548,21979,'hypothalamus cell differentiation','P','The differentiation of cells that will contribute to the structure and function of the hypothalamus.','2013-10-27','NSRP'),(13549,21980,'subpallium cell migration','P','The orderly movement of cells from one site to another in the subpallium.','2013-10-27','NSRP'),(13550,21981,'subpallium radially oriented migration','P','The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain.','2013-10-27','NSRP'),(13551,21982,'pineal gland development','P','The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms.','2013-10-27','NSRP'),(13552,21983,'pituitary gland development','P','The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands.','2013-10-27','NSRP'),(13553,21984,'adenohypophysis development','P','The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.','2013-10-27','NSRP'),(13554,21985,'neurohypophysis development','P','The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation.','2013-10-27','NSRP'),(13555,21986,'habenula development','P','The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland.','2013-10-27','NSRP'),(13556,21987,'cerebral cortex development','P','The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.','2013-10-27','NSRP'),(13557,21988,'olfactory lobe development','P','The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell.','2013-10-27','NSRP'),(13558,21989,'olfactory cortex development','P','The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors.','2013-10-27','NSRP'),(13559,21990,'neural plate formation','P','The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.','2013-10-27','NSRP'),(13560,21991,'neural plate thickening','P','The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode.','2013-10-27','NSRP'),(13561,21992,'cell proliferation involved in neural plate elongation','P','The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue.','2013-10-27','NSRP'),(13562,21993,'initiation of neural tube closure','P','The process in which closure points are established at multiple points and along the neural rostrocaudal axis.','2013-10-27','NSRP'),(13563,21994,'progression of neural tube closure','P','The process in which the neural folds are fused extending from the initial closure points.','2013-10-27','NSRP'),(13564,21995,'neuropore closure','P','The process of joining together the neural folds at either end of the neural tube.','2013-10-27','NSRP'),(13565,21996,'lamina terminalis formation','P','The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore.','2013-10-27','NSRP'),(13566,21997,'neural plate axis specification','P','The pattern specification process in which the axes of the nervous system are established.','2013-10-27','NSRP'),(13567,21998,'neural plate mediolateral regionalization','P','The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate.','2013-10-27','NSRP'),(13568,21999,'neural plate anterior/posterior regionalization','P','The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate.','2013-10-27','NSRP'),(13569,22000,'forebrain induction by the anterior neural ridge','P','The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate.','2013-10-27','NSRP'),(13570,22001,'negative regulation of anterior neural cell fate commitment of the neural plate','P','Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate.','2013-10-27','NSRP'),(13571,22002,'negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway','P','The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell.','2013-10-27','NSRP'),(13572,22003,'negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway','P','The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.','2013-10-27','NSRP'),(13573,22004,'midbrain-hindbrain boundary maturation during brain development','P','A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.','2013-10-27','NSRP'),(13574,22005,'midbrain-hindbrain boundary maturation during neural plate development','P','A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate.','2013-10-27','NSRP'),(13575,22006,'zona limitans intrathalamica formation','P','The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon.','2013-10-27','NSRP'),(13576,22007,'convergent extension involved in neural plate elongation','P','The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate.','2013-10-27','NSRP'),(13577,22008,'neurogenesis','P','Generation of cells within the nervous system.','2013-10-27','NSRP'),(13578,22009,'central nervous system vasculogenesis','P','The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier.','2013-10-27','NSRP'),(13579,22010,'central nervous system myelination','P','The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.','2013-10-27','NSRP'),(13580,22011,'myelination in peripheral nervous system','P','The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.','2013-10-27','NSRP'),(13581,22012,'subpallium cell proliferation in forebrain','P','The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(13582,22013,'pallium cell proliferation in forebrain','P','The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population.','2013-10-27','NSRP'),(13583,22014,'radial glial cell division in subpallium','P','The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes.','2013-10-27','NSRP'),(13584,22015,'radial glial cell division in pallium','P','The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes.','2013-10-27','NSRP'),(13585,22016,'pallium glioblast division','P','The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells.','2013-10-27','NSRP'),(13586,22017,'neuroblast division in pallium','P','The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons.','2013-10-27','NSRP'),(13587,22018,'lateral ganglionic eminence cell proliferation','P','The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population.','2013-10-27','NSRP'),(13588,22019,'dorsal lateral ganglionic eminence cell proliferation','P','The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population.','2013-10-27','NSRP'),(13589,22020,'medial ganglionic eminence cell proliferation','P','The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(13590,22021,'caudal ganglionic eminence cell proliferation','P','The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(13591,22022,'septal cell proliferation','P','The multiplication or reproduction of septal cells, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(13592,22023,'radial glial cell fate commitment in forebrain','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain.','2013-10-27','NSRP'),(13593,22024,'BMP signaling pathway involved in forebrain neuron fate commitment','P','A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.','2013-10-27','NSRP'),(13594,22025,'leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment','P','Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.','2013-10-27','NSRP'),(13595,22026,'epidermal growth factor signaling pathway involved in forebrain neuron fate commitment','P','The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.','2013-10-27','NSRP'),(13596,22027,'interkinetic nuclear migration','P','The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle.','2013-10-27','NSRP'),(13597,22028,'tangential migration from the subventricular zone to the olfactory bulb','P','The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration.','2013-10-27','NSRP'),(13598,22029,'telencephalon cell migration','P','The orderly movement of a cell from one site to another at least one of which is located in the telencephalon.','2013-10-27','NSRP'),(13599,22030,'telencephalon glial cell migration','P','The orderly movement of glial cells through the telencephalon.','2013-10-27','NSRP'),(13600,22031,'telencephalon astrocyte cell migration','P','The orderly movement of an astrocyte cell through the telencephalon.','2013-10-27','NSRP'),(13601,22032,'telencephalon oligodendrocyte cell migration','P','The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(13602,22033,'telencephalon microglial cell migration','P','The orderly movement of microglial cells through the telencephalon.','2013-10-27','NSRP'),(13603,22034,'rhombomere cell proliferation','P','The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population.','2013-10-27','NSRP'),(13604,22035,'rhombomere cell migration','P','The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere.','2013-10-27','NSRP'),(13605,22036,'rhombomere cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell.','2013-10-27','NSRP'),(13606,22037,'metencephalon development','P','The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13607,22038,'corpus callosum development','P','The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres.','2013-10-27','NSRP'),(13608,22400,'regulation of rhodopsin mediated signaling pathway','P','Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.','2013-10-27','NSRP'),(13609,22401,'negative adaptation of signaling pathway','P','The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.','2013-10-27','NSRP'),(13610,22402,'cell cycle process','P','The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.','2013-10-27','NSRP'),(13611,22403,'cell cycle phase','P','One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events.','2013-10-27','NSRP'),(13612,22404,'molting cycle process','P','A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin.','2013-10-27','NSRP'),(13613,22405,'hair cycle process','P','A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.','2013-10-27','NSRP'),(13614,22406,'membrane docking','P','The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere.','2013-10-27','NSRP'),(13615,22407,'regulation of cell-cell adhesion','P','Any process that modulates the frequency, rate or extent of attachment of a cell to another cell.','2013-10-27','NSRP'),(13616,22408,'negative regulation of cell-cell adhesion','P','Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell.','2013-10-27','NSRP'),(13617,22409,'positive regulation of cell-cell adhesion','P','Any process that activates or increases the rate or extent of cell adhesion to another cell.','2013-10-27','NSRP'),(13618,22410,'circadian sleep/wake cycle process','P','A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.','2013-10-27','NSRP'),(13619,22411,'cellular component disassembly','P','A cellular process that results in the breakdown of a cellular component.','2013-10-27','NSRP'),(13620,22412,'cellular process involved in reproduction in multicellular organism','P','A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism.','2013-10-27','NSRP'),(13621,22413,'reproductive process in single-celled organism','P','A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism.','2013-10-27','NSRP'),(13622,22414,'reproductive process','P','A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.','2013-10-27','NSRP'),(13623,22415,'viral reproductive process','P','A reproductive process involved in viral reproduction. Usually, this is by infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, \'complete\' its life cycle.','2013-05-06','NSRP'),(13624,22416,'chaeta development','P','The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.','2013-10-27','NSRP'),(13625,22417,'protein maturation by protein folding','P','The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein.','2013-10-27','NSRP'),(13626,22600,'digestive system process','P','A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.','2013-10-27','NSRP'),(13627,22601,'menstrual cycle phase','P','The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur.','2013-10-27','NSRP'),(13628,22602,'ovulation cycle process','P','A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.','2013-10-27','NSRP'),(13629,22603,'regulation of anatomical structure morphogenesis','P','Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis.','2013-10-27','NSRP'),(13630,22604,'regulation of cell morphogenesis','P','Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized.','2013-10-27','NSRP'),(13631,22605,'oogenesis stage','P','A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell.','2013-10-27','NSRP'),(13632,22606,'establishment of proximal/distal cell polarity','P','The specification and formation of the polarity of a cell along its proximal/distal axis.','2013-10-27','NSRP'),(13633,22607,'cellular component assembly','P','The aggregation, arrangement and bonding together of a cellular component.','2013-10-27','NSRP'),(13634,22608,'multicellular organism adhesion','P','The attachment of a multicellular organism to a substrate or other organism.','2013-10-27','NSRP'),(13635,22609,'multicellular organism adhesion to substrate','P','The attachment of a multicellular organism to a surface or material.','2013-10-27','NSRP'),(13636,22610,'biological adhesion','P','The attachment of a cell or organism to a substrate or other organism.','2013-10-27','NSRP'),(13637,22611,'dormancy process','P','A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated.','2013-10-27','NSRP'),(13638,22612,'gland morphogenesis','P','The process in which the anatomical structures of a gland are generated and organized.','2013-10-27','NSRP'),(13639,22613,'ribonucleoprotein complex biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex.','2013-10-27','NSRP'),(13640,22614,'membrane to membrane docking','P','The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere.','2013-10-27','NSRP'),(13641,22615,'protein to membrane docking','P','The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere.','2013-10-27','NSRP'),(13642,22616,'DNA strand elongation','P','The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3\' end of an existing DNA stand.','2013-10-27','NSRP'),(13643,22617,'extracellular matrix disassembly','P','A process that results in the breakdown of the extracellular matrix.','2013-10-27','NSRP'),(13644,22618,'ribonucleoprotein complex assembly','P','The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex.','2013-10-27','NSRP'),(13645,22619,'generative cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte.','2013-10-27','NSRP'),(13646,22620,'vegetative cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube.','2013-10-27','NSRP'),(13647,22621,'shoot system development','P','The process whose specific outcome is the progression of the shoot system over time, from its formation to the mature structure.','2012-03-14','NSRP'),(13648,22622,'root system development','P','The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure.','2013-10-27','NSRP'),(13649,22623,'proteasome-activating nucleotidase complex','C','A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner.','2013-10-27','NSRP'),(13650,22624,'proteasome accessory complex','C','A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex.','2013-10-27','NSRP'),(13651,22625,'cytosolic large ribosomal subunit','C','The large subunit of a ribosome located in the cytosol.','2013-10-27','NSRP'),(13652,22626,'cytosolic ribosome','C','A ribosome located in the cytosol.','2013-10-27','NSRP'),(13653,22627,'cytosolic small ribosomal subunit','C','The small subunit of a ribosome located in the cytosol.','2013-10-27','NSRP'),(13654,22628,'chloroplast large ribosomal subunit','C','The large subunit of a ribosome contained within a chloroplast.','2013-10-27','NSRP'),(13655,22629,'chloroplast small ribosomal subunit','C','The small subunit of a ribosome contained within a chloroplast.','2013-10-27','NSRP'),(13656,22803,'passive transmembrane transporter activity','F','Catalysis of the transfer of a solute from one side of the membrane to the other, down the solute\'s concentration gradient.','2013-10-27','NSRP'),(13657,22804,'active transmembrane transporter activity','F','Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute\'s concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.','2013-10-27','NSRP'),(13658,22809,'mobile ion carrier activity','F','This is a type of carrier produced by bacteria. It enables passive transport by shielding the ion that is being transported from the lipid membrane. It carries an ion across the membrane by enclosing the ion and travelling across the membrane. It does not form a fully open pore across the membrane.','2013-10-27','NSRP'),(13659,22810,'membrane potential driven uniporter activity','F','Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.','2013-10-27','NSRP'),(13660,22814,'facilitated diffusion','F','Catalysis of the transfer of a single solute from one side of the membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged.','2013-10-27','NSRP'),(13661,22815,'large uncharged polar molecule transmembrane transporter activity','F','OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other.','2013-10-27','NSRP'),(13662,22818,'sodium ion uniporter activity','F','Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.','2013-10-27','NSRP'),(13663,22819,'potassium ion uniporter activity','F','Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged.','2013-10-27','NSRP'),(13664,22820,'potassium ion symporter activity','F','Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.','2013-10-27','NSRP'),(13665,22821,'potassium ion antiporter activity','F','Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.','2013-10-27','NSRP'),(13666,22824,'transmitter-gated ion channel activity','F','Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(13667,22825,'copper-exporting ATPase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13668,22828,'phosphorylation-gated channel activity','F','Catalysis of the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts.','2013-10-27','NSRP'),(13669,22829,'wide pore channel activity','F','Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts.','2013-10-27','NSRP'),(13670,22831,'narrow pore, gated channel activity','F','Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus.','2013-10-27','NSRP'),(13671,22832,'voltage-gated channel activity','F','Catalysis of the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(13672,22833,'mechanically gated channel activity','F','Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a mechanical stress.','2013-10-27','NSRP'),(13673,22834,'ligand-gated channel activity','F','Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(13674,22835,'transmitter-gated channel activity','F','Catalysis of the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(13675,22836,'gated channel activity','F','Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus.','2013-10-27','NSRP'),(13676,22838,'substrate-specific channel activity','F','Catalysis of energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.','2013-10-27','NSRP'),(13677,22839,'ion gated channel activity','F','Catalysis of the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus.','2013-10-27','NSRP'),(13678,22840,'leak channel activity','F','Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or \'resting\' state.','2013-10-27','NSRP'),(13679,22841,'potassium ion leak channel activity','F','Catalysis of the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or \'resting\' state.','2013-10-27','NSRP'),(13680,22842,'narrow pore channel activity','F','Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated.','2013-10-27','NSRP'),(13681,22843,'voltage-gated cation channel activity','F','Catalysis of the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(13682,22848,'acetylcholine-gated cation channel activity','F','Catalysis of the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(13683,22849,'glutamate-gated calcium ion channel activity','F','Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(13684,22850,'serotonin-gated cation channel activity','F','Catalysis of the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(13685,22851,'GABA-gated chloride ion channel activity','F','Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(13686,22852,'glycine-gated chloride ion channel activity','F','Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(13687,22853,'active ion transmembrane transporter activity','F','Catalysis of the transfer of an ion from one side of a membrane to the other up the solute\'s concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction.','2013-10-27','NSRP'),(13688,22854,'active large uncharged polar molecule transmembrane transporter activity','F','OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute\'s concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction.','2013-10-27','NSRP'),(13689,22855,'protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13690,22856,'protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13691,22857,'transmembrane transporter activity','F','Enables the transfer of a substance from one side of a membrane to the other.','2013-10-27','NSRP'),(13692,22858,'alanine transmembrane transporter activity','F','Catalysis of the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid.','2013-10-27','NSRP'),(13693,22859,'dephosphorylation-gated channel activity','F','Catalysis of the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts.','2013-10-27','NSRP'),(13694,22865,'transmembrane electron transfer carrier','F','Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics.','2013-10-27','NSRP'),(13695,22866,'transmembrane 1-electron transfer carrier','F','Enables transfer of one electron across a membrane.','2013-10-27','NSRP'),(13696,22867,'transmembrane 2-electron transfer carrier','F','Enables transfer of two electrons across a membrane.','2013-10-27','NSRP'),(13697,22869,'protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13698,22870,'protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13699,22871,'protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13700,22872,'protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13701,22873,'protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13702,22874,'protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13703,22875,'protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13704,22876,'protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13705,22877,'protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13706,22878,'protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13707,22879,'protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13708,22880,'protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13709,22881,'protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13710,22882,'protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(13711,22883,'zinc efflux transmembrane transporter activity','F','Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane.','2013-10-27','NSRP'),(13712,22884,'macromolecule transmembrane transporter activity','F','Catalysis of the transfer of a macromolecule from one side of the membrane to the other.','2013-10-27','NSRP'),(13713,22885,'bacteriocin transmembrane transporter activity','F','Catalysis of the transfer of a bacteriocin from one side of the membrane to the other.','2013-10-27','NSRP'),(13714,22886,'channel-forming ionophore activity','F','Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive.','2013-10-27','NSRP'),(13715,22889,'serine transmembrane transporter activity','F','Catalysis of the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid.','2013-10-27','NSRP'),(13716,22890,'inorganic cation transmembrane transporter activity','F','Catalysis of the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage.','2013-10-27','NSRP'),(13717,22891,'substrate-specific transmembrane transporter activity','F','Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other.','2013-10-27','NSRP'),(13718,22892,'substrate-specific transporter activity','F','Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(13719,22893,'low-affinity tryptophan transmembrane transporter activity','F','Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid.','2013-10-27','NSRP'),(13720,22894,'Intermediate conductance calcium-activated potassium channel activity','F','Catalysis of the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism.','2013-10-27','NSRP'),(13721,22897,'proton-dependent peptide secondary active transmembrane transporter activity','F','Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement.','2013-10-27','NSRP'),(13722,22898,'regulation of transmembrane transporter activity','P','Any process that modulates the frequency, rate or extent of transmembrane transporter activity.','2013-10-27','NSRP'),(13723,22900,'electron transport chain','P','A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.','2013-10-27','NSRP'),(13724,22904,'respiratory electron transport chain','P','A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.','2013-10-27','NSRP'),(13725,23002,'nuclear migration to embryo sac poles','P','Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell.','2013-10-27','NSRP'),(13726,23003,'nuclear migration to the embryo sac center','P','Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell.','2013-10-27','NSRP'),(13727,23004,'activation of dopamine receptor signaling pathway','P','OBSOLETE. Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor.','2013-10-27','NSRP'),(13728,23005,'signal initiation by neurotransmitter','P','OBSOLETE. The process in which a neurotransmitter signal causes activation of a receptor.','2013-10-27','NSRP'),(13729,23006,'signal initiation by amino acid','P','OBSOLETE. The process in which an amino acid signal causes activation of a receptor.','2013-10-27','NSRP'),(13730,23007,'ligand binding to T cell receptor','P','OBSOLETE. Binding of a diffusible ligand to a T cell receptor as part of a signaling process.','2013-10-27','NSRP'),(13731,23009,'initiation of T cell receptor signaling','P','OBSOLETE. The process in which a signal causes activation of T cell receptor signaling.','2013-10-27','NSRP'),(13732,23010,'regulation of initiation of T cell receptor signaling','P','OBSOLETE. Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling.','2013-10-27','NSRP'),(13733,23011,'positive regulation of initiation of T cell receptor signaling','P','OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling.','2013-10-27','NSRP'),(13734,23012,'initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor','P','OBSOLETE. The process in which binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling.','2013-10-27','NSRP'),(13735,23014,'signal transduction by phosphorylation','P','A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate.','2013-10-27','NSRP'),(13736,23015,'signal transduction by cis-phosphorylation','P','A process in which the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule transmits a signal. For example, ligand-binding can induce autophosphorylation of the activated receptor, creating binding sites for intracellular signaling molecules.','2013-10-27','NSRP'),(13737,23016,'signal transduction by trans-phosphorylation','P','A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different molecule transmits a signal.','2013-10-27','NSRP'),(13738,23017,'signal transmission via diffusible molecule','P','OBSOLETE. The process in which a signal is conveyed via a diffusible molecule.','2013-10-27','NSRP'),(13739,23018,'T cell activation of signal transmission via diffusible molecule','P','OBSOLETE. The process in which signal transmission via a diffusible molecule is initiated by a T cell.','2013-10-27','NSRP'),(13740,23019,'signal transduction involved in regulation of gene expression','P','Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another.','2013-10-27','NSRP'),(13741,23020,'regulation of gene expression as a consequence of T cell signal transmission','P','OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a T cell signal is released and/or conveyed from one location to another.','2013-10-27','NSRP'),(13742,23021,'termination of signal transduction','P','The signaling process in which signal transduction is brought to an end rather than being reversibly modulated.','2013-10-27','NSRP'),(13743,23022,'termination of T cell signal transduction','P','The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated.','2013-10-27','NSRP'),(13744,23023,'MHC protein complex binding','F','Interacting selectively and non-covalently with the major histocompatibility complex.','2013-10-27','NSRP'),(13745,23024,'MHC class I protein complex binding','F','Interacting selectively and non-covalently with the class I major histocompatibility complex.','2013-10-27','NSRP'),(13746,23025,'MHC class Ib protein complex binding','F','Interacting selectively and non-covalently with the class Ib major histocompatibility complex.','2013-10-27','NSRP'),(13747,23026,'MHC class II protein complex binding','F','Interacting selectively and non-covalently with the class II major histocompatibility complex.','2013-10-27','NSRP'),(13748,23027,'MHC class I protein binding, via antigen binding groove','F','Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the antigen binding groove.','2013-10-27','NSRP'),(13749,23028,'MHC class I protein binding, via lateral surface','F','Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the lateral surface.','2013-10-27','NSRP'),(13750,23029,'MHC class Ib protein binding','F','Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules.','2013-10-27','NSRP'),(13751,23030,'MHC class Ib protein binding, via antigen binding groove','F','Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the antigen binding groove.','2013-10-27','NSRP'),(13752,23031,'MHC class Ib protein binding, via lateral surface','F','Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the lateral surface.','2013-10-27','NSRP'),(13753,23035,'CD40 signaling pathway','P','A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(13754,23036,'initiation of signal transduction','P','OBSOLETE. The process in which a signal causes activation of a receptor, for example, via a conformation change.','2013-10-27','NSRP'),(13755,23037,'signal initiation by light','P','OBSOLETE. The process in which a light signal causes activation of a receptor.','2013-10-27','NSRP'),(13756,23038,'signal initiation by diffusible mediator','P','OBSOLETE. The process in which a diffusible signal causes activation of a receptor.','2013-10-27','NSRP'),(13757,23039,'signal initiation by physical damage','P','OBSOLETE. The process in which a physical damage signal causes activation of a receptor.','2013-10-27','NSRP'),(13758,23040,'signaling via ionic flux','P','OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via ionic flux.','2013-10-27','NSRP'),(13759,23041,'neuronal signal transduction','P','The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular.','2013-10-27','NSRP'),(13760,23042,'signaling via protein/peptide mediator','P','OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator.','2013-10-27','NSRP'),(13761,23043,'signaling via lipid mediator','P','OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator.','2013-10-27','NSRP'),(13762,23044,'signaling via chemical mediator','P','OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator.','2013-10-27','NSRP'),(13763,23045,'signal transduction by conformational transition','P','A process where induction of a conformational change in a molecule transmits a signal to that molecule.','2013-10-27','NSRP'),(13764,23047,'signal initiation by chemical mediator','P','OBSOLETE. The process in which a chemical signal causes activation of a receptor.','2013-10-27','NSRP'),(13765,23048,'signal initiation by lipid mediator','P','OBSOLETE. The process in which a lipid signal causes activation of a receptor.','2013-10-27','NSRP'),(13766,23049,'signal initiation by protein/peptide mediator','P','OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor.','2013-10-27','NSRP'),(13767,23050,'consequence of signal transmission','P','OBSOLETE. The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state.','2013-10-27','NSRP'),(13768,23051,'regulation of signaling','P','Any process that modulates the frequency, rate or extent of a signaling process.','2013-10-27','NSRP'),(13769,23052,'signaling','P','The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.','2013-10-27','NSRP'),(13770,23053,'signal initiation by mechanical effect','P','OBSOLETE. The process in which a mechanical signal causes activation of a receptor.','2013-10-27','NSRP'),(13771,23054,'signal initiation by stretch effect','P','OBSOLETE. The process in which a stretch signal causes activation of a receptor.','2013-10-27','NSRP'),(13772,23055,'signal initiation by peptide hormone','P','OBSOLETE. The process in which a signal is initiated by a peptide hormone.','2013-10-27','NSRP'),(13773,23056,'positive regulation of signaling','P','Any process that activates, maintains or increases the frequency, rate or extent of a signaling process.','2013-10-27','NSRP'),(13774,23057,'negative regulation of signaling','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.','2013-10-27','NSRP'),(13775,23058,'adaptation of signaling pathway','P','The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.','2013-10-27','NSRP'),(13776,23059,'positive adaptation of signaling pathway','P','The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.','2013-10-27','NSRP'),(13777,23060,'signal transmission','P','OBSOLETE. The process in which a signal is released and/or conveyed from one location to another.','2013-10-27','NSRP'),(13778,23061,'signal release','P','The process in which a signal is secreted or discharged into the extracellular medium from a cellular source.','2013-10-27','NSRP'),(13779,23062,'signal transmission via transcytosis','P','OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.','2013-10-27','NSRP'),(13780,23065,'signal transmission via blood','P','OBSOLETE. The process in which a signal is conveyed via blood.','2013-10-27','NSRP'),(13781,23066,'signal transmission via vascular system','P','OBSOLETE. The process in which a signal is conveyed via the vascular system.','2013-10-27','NSRP'),(13782,23067,'signal transmission via lymphatic system','P','OBSOLETE. The process in which a signal is conveyed via the lymphatic system.','2013-10-27','NSRP'),(13783,23068,'signal transmission via phloem','P','OBSOLETE. The process in which a signal is conveyed via the phloem.','2013-10-27','NSRP'),(13784,23069,'signal transmission via xylem','P','OBSOLETE. The process in which a signal is conveyed via the xylem.','2013-10-27','NSRP'),(13785,23070,'signal transmission via air','P','OBSOLETE. The process in which a signal is conveyed via the air.','2013-10-27','NSRP'),(13786,30001,'metal ion transport','P','The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(13787,30002,'cellular anion homeostasis','P','Any process involved in the maintenance of an internal steady state of anions at the level of a cell.','2013-10-27','NSRP'),(13788,30003,'cellular cation homeostasis','P','Any process involved in the maintenance of an internal steady state of cations at the level of a cell.','2013-10-27','NSRP'),(13789,30004,'cellular monovalent inorganic cation homeostasis','P','Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell.','2013-10-27','NSRP'),(13790,30005,'cellular di-, tri-valent inorganic cation homeostasis','P','Any process involved in the maintenance of an internal steady state of divalent or trivalent cations at the level of a cell.','2013-10-27','NSRP'),(13791,30006,'heavy cellular metal ion homeostasis','P','OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn.','2013-10-27','NSRP'),(13792,30007,'cellular potassium ion homeostasis','P','Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.','2013-10-27','NSRP'),(13793,30008,'TRAPP complex','C','A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active.','2013-10-27','NSRP'),(13794,30009,'complement factor H activity','F','OBSOLETE. A cofactor for the serine protease complement factor I.','2013-10-27','NSRP'),(13795,30010,'establishment of cell polarity','P','The specification and formation of anisotropic intracellular organization or cell growth patterns.','2013-10-27','NSRP'),(13796,30011,'maintenance of cell polarity','P','The maintenance of established anisotropic intracellular organization or cell growth patterns.','2013-10-27','NSRP'),(13797,30014,'CCR4-NOT complex','C','The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.','2013-10-27','NSRP'),(13798,30015,'CCR4-NOT core complex','C','The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.','2013-10-27','NSRP'),(13799,30016,'myofibril','C','The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism.','2013-10-27','NSRP'),(13800,30017,'sarcomere','C','The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.','2013-10-27','NSRP'),(13801,30018,'Z disc','C','Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.','2013-10-27','NSRP'),(13802,30019,'tryptase activity','F','OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin.','2013-10-27','NSRP'),(13803,30020,'extracellular matrix structural constituent conferring tensile strength','F','A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress.','2013-10-27','NSRP'),(13804,30021,'extracellular matrix structural constituent conferring compression resistance','F','A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.','2013-10-27','NSRP'),(13805,30022,'adhesive extracellular matrix constituent','F','OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix.','2013-10-27','NSRP'),(13806,30023,'extracellular matrix constituent conferring elasticity','F','A component of the extracellular matrix that enables the matrix to recoil after transient stretching.','2013-10-27','NSRP'),(13807,30026,'cellular manganese ion homeostasis','P','Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell.','2013-10-27','NSRP'),(13808,30027,'lamellipodium','C','A thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.','2013-10-27','NSRP'),(13809,30029,'actin filament-based process','P','Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins.','2013-10-27','NSRP'),(13810,30030,'cell projection organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.','2013-10-27','NSRP'),(13811,30031,'cell projection assembly','P','Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.','2013-10-27','NSRP'),(13812,30032,'lamellipodium assembly','P','Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.','2013-10-27','NSRP'),(13813,30033,'microvillus assembly','P','Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.','2013-10-27','NSRP'),(13814,30034,'microvillar actin bundle assembly','P','Assembly of the parallel bundle of actin filaments at the core of a microvillus.','2013-10-27','NSRP'),(13815,30035,'microspike assembly','P','Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell.','2013-10-27','NSRP'),(13816,30036,'actin cytoskeleton organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.','2013-10-27','NSRP'),(13817,30037,'actin filament reorganization involved in cell cycle','P','The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs.','2013-10-27','NSRP'),(13818,30038,'contractile actin filament bundle assembly','P','Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle.','2013-10-27','NSRP'),(13819,30039,'DNA unwinding factor','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13820,30041,'actin filament polymerization','P','Assembly of actin filaments by the addition of actin monomers to a filament.','2013-10-27','NSRP'),(13821,30042,'actin filament depolymerization','P','Disassembly of actin filaments by the removal of actin monomers from a filament.','2013-10-27','NSRP'),(13822,30043,'actin filament fragmentation','P','The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins.','2013-10-27','NSRP'),(13823,30046,'parallel actin filament bundle assembly','P','Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity.','2013-10-27','NSRP'),(13824,30047,'actin modification','P','Covalent modification of an actin molecule.','2013-10-27','NSRP'),(13825,30048,'actin filament-based movement','P','Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins.','2013-10-27','NSRP'),(13826,30049,'muscle filament sliding','P','The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated.','2013-10-27','NSRP'),(13827,30050,'vesicle transport along actin filament','P','Movement of a vesicle along an actin filament, mediated by motor proteins.','2013-10-27','NSRP'),(13828,30051,'FK506-sensitive peptidyl-prolyl cis-trans isomerase','F','OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0)).','2013-10-27','NSRP'),(13829,30052,'parvulin','F','OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin.','2013-10-27','NSRP'),(13830,30053,'immunophilin','F','OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin.','2013-10-27','NSRP'),(13831,30054,'cell junction','C','A cellular component that forms a specialized region of connection between two cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.','2013-10-27','NSRP'),(13832,30055,'cell-substrate junction','C','A cell junction that forms a connection between a cell and the extracellular matrix.','2013-10-27','NSRP'),(13833,30056,'hemidesmosome','C','A cell-substrate junction that forms a point of contact between the basal surface of epithelial cells and the basal lamina. Morphologically resembles desmosomes; attached to intermediate filaments.','2013-10-27','NSRP'),(13834,30057,'desmosome','C','A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism.','2013-10-27','NSRP'),(13835,30058,'amine dehydrogenase activity','F','Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor.','2013-10-27','NSRP'),(13836,30059,'aralkylamine dehydrogenase (azurin) activity','F','Catalysis of the reaction: H(2)O + arCH(2)NH(2) + 2 azurin = 2 reduced azurin + ArCHO + NH(3). The symbol arCH(2)NH(2) represents an aralkylamine and ArCHO is an aryl aldehyde.','2013-10-27','NSRP'),(13837,30060,'L-malate dehydrogenase activity','F','Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.','2013-10-27','NSRP'),(13838,30061,'mitochondrial crista','C','Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.','2013-10-27','NSRP'),(13839,30062,'mitochondrial tricarboxylic acid cycle enzyme complex','C','Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle.','2013-10-27','NSRP'),(13840,30063,'murein sacculus','C','OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall.','2013-10-27','NSRP'),(13841,30064,'cell wall inner membrane','C','OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria.','2013-10-27','NSRP'),(13842,30066,'cytochrome b6','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13843,30067,'respiratory chain cytochrome b6','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13844,30068,'lytic viral life cycle','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13845,30069,'lysogeny','P','The incorporation of a bacteriophage genome into the genome of its bacterial host organism.','2012-03-14','NSRP'),(13846,30070,'insulin processing','P','The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges.','2013-10-27','NSRP'),(13847,30071,'regulation of mitotic metaphase/anaphase transition','P','Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle.','2013-10-27','NSRP'),(13848,30072,'peptide hormone secretion','P','The regulated release of a peptide hormone from a cell.','2013-10-27','NSRP'),(13849,30073,'insulin secretion','P','The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin.','2013-10-27','NSRP'),(13850,30074,'thylakoid (sensu Proteobacteria)','C','OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224).','2013-10-27','NSRP'),(13851,30075,'bacterial thylakoid','C','A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria.','2013-10-27','NSRP'),(13852,30076,'light-harvesting complex','C','A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center.','2013-10-27','NSRP'),(13853,30077,'plasma membrane light-harvesting complex','C','A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species.','2013-10-27','NSRP'),(13854,30078,'light-harvesting complex, core complex','C','Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria.','2013-10-27','NSRP'),(13855,30079,'light-harvesting complex, peripheral complex','C','Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center.','2013-10-27','NSRP'),(13856,30080,'B875 antenna complex','C','Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm.','2013-10-27','NSRP'),(13857,30081,'B800-820 antenna complex','C','Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.','2013-10-27','NSRP'),(13858,30082,'B800-850 antenna complex','C','Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex.','2013-10-27','NSRP'),(13859,30083,'PSI associated light-harvesting complex I, LHCIa subcomplex','C','A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm.','2013-10-27','NSRP'),(13860,30084,'PSI associated light-harvesting complex I, LHCIb subcomplex','C','A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm.','2013-10-27','NSRP'),(13861,30085,'PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex','C','A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides.','2013-10-27','NSRP'),(13862,30086,'PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13863,30087,'PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13864,30088,'PSII associated light-harvesting complex II, core complex, LHCIId subcomplex','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(13865,30089,'phycobilisome','C','Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II.','2013-10-27','NSRP'),(13866,30091,'protein repair','P','The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues.','2013-10-27','NSRP'),(13867,30092,'regulation of flagellum assembly','P','OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum.','2013-10-27','NSRP'),(13868,30093,'chloroplast photosystem I','C','Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(13869,30094,'plasma membrane-derived photosystem I','C','A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species.','2013-10-27','NSRP'),(13870,30095,'chloroplast photosystem II','C','An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.','2013-10-27','NSRP'),(13871,30096,'plasma membrane-derived thylakoid photosystem II','C','A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone.','2013-10-27','NSRP'),(13872,30097,'hemopoiesis','P','The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.','2013-10-27','NSRP'),(13873,30098,'lymphocyte differentiation','P','The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.','2013-10-27','NSRP'),(13874,30099,'myeloid cell differentiation','P','The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.','2013-10-27','NSRP'),(13875,30100,'regulation of endocytosis','P','Any process that modulates the frequency, rate or extent of endocytosis.','2013-10-27','NSRP'),(13876,30101,'natural killer cell activation','P','The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(13877,30103,'vasopressin secretion','P','The regulated release of vasopressin from secretory granules into the blood.','2013-10-27','NSRP'),(13878,30104,'water homeostasis','P','Any process involved in the maintenance of an internal steady state of water within an organism or cell.','2013-10-27','NSRP'),(13879,30105,'anaphylaxis','P','OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances.','2013-10-27','NSRP'),(13880,30106,'MHC class I receptor activity','F','OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells).','2013-10-27','NSRP'),(13881,30107,'HLA-A specific inhibitory MHC class I receptor activity','F','Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.','2013-10-27','NSRP'),(13882,30108,'HLA-A specific activating MHC class I receptor activity','F','Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte.','2013-10-27','NSRP'),(13883,30109,'HLA-B specific inhibitory MHC class I receptor activity','F','Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte.','2013-10-27','NSRP'),(13884,30110,'HLA-C specific inhibitory MHC class I receptor activity','F','Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte.','2013-10-27','NSRP'),(13885,30111,'regulation of Wnt receptor signaling pathway','P','Any process that modulates the frequency, rate or extent of the activity of the Wnt receptor mediated signal transduction pathway.','2013-10-27','NSRP'),(13886,30112,'glycocalyx','C','A viscous, carbohydrate rich layer at the outermost periphery of a cell.','2013-10-27','NSRP'),(13887,30114,'slime layer','C','A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids.','2013-10-27','NSRP'),(13888,30115,'S-layer','C','A crystalline protein layer surrounding some bacteria.','2013-10-27','NSRP'),(13889,30116,'glial cell line-derived neurotrophic factor receptor binding','F','A growth factor that binds selectively and non-covalently to glial cell line-derived neurotrophic factor receptors.','2013-10-27','NSRP'),(13890,30117,'membrane coat','C','Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.','2013-10-27','NSRP'),(13891,30118,'clathrin coat','C','A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.','2013-10-27','NSRP'),(13892,30119,'AP-type membrane coat adaptor complex','C','Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa).','2013-10-27','NSRP'),(13893,30120,'vesicle coat','C','A membrane coat found on a coated vesicle.','2013-10-27','NSRP'),(13894,30121,'AP-1 adaptor complex','C','A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).','2013-10-27','NSRP'),(13895,30122,'AP-2 adaptor complex','C','A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).','2013-10-27','NSRP'),(13896,30123,'AP-3 adaptor complex','C','A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).','2013-10-27','NSRP'),(13897,30124,'AP-4 adaptor complex','C','An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo.','2013-10-27','NSRP'),(13898,30125,'clathrin vesicle coat','C','A clathrin coat found on a vesicle.','2013-10-27','NSRP'),(13899,30126,'COPI vesicle coat','C','One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta\'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.','2013-10-27','NSRP'),(13900,30127,'COPII vesicle coat','C','One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state.','2013-10-27','NSRP'),(13901,30128,'clathrin coat of endocytic vesicle','C','A clathrin coat found on an endocytic vesicle.','2013-10-27','NSRP'),(13902,30129,'clathrin coat of synaptic vesicle','C','A clathrin coat found on a synaptic vesicle.','2013-10-27','NSRP'),(13903,30130,'clathrin coat of trans-Golgi network vesicle','C','A clathrin coat found on a vesicle of the trans-Golgi network.','2013-10-27','NSRP'),(13904,30131,'clathrin adaptor complex','C','A membrane coat adaptor complex that links clathrin to a membrane.','2013-10-27','NSRP'),(13905,30132,'clathrin coat of coated pit','C','The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.','2013-10-27','NSRP'),(13906,30133,'transport vesicle','C','Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, or to destinations within or outside the cell.','2013-10-27','NSRP'),(13907,30134,'ER to Golgi transport vesicle','C','A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport.','2013-10-27','NSRP'),(13908,30135,'coated vesicle','C','Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.','2013-10-27','NSRP'),(13909,30136,'clathrin-coated vesicle','C','A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.','2013-10-27','NSRP'),