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--
-- Table structure for table `GO`
--

CREATE TABLE `GO` (
  `GO_NO` int(11) NOT NULL AUTO_INCREMENT,
  `GOID` int(11) NOT NULL,
  `GO_TERM` varchar(240) NOT NULL,
  `GO_ASPECT` varchar(40) NOT NULL,
  `GO_DEFINITION` varchar(2000) DEFAULT NULL,
  `DATE_CREATED` date NOT NULL,
  `CREATED_BY` varchar(12) NOT NULL,
  PRIMARY KEY (`GO_NO`)
) ENGINE=InnoDB AUTO_INCREMENT=40186 DEFAULT CHARSET=utf8;

--
-- Dumping data for table `GO`
--

INSERT INTO `GO` VALUES (1,1,'mitochondrion inheritance','P','The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton.','2013-10-27','NSRP'),(2,2,'mitochondrial genome maintenance','P','The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.','2013-10-27','NSRP'),(3,3,'reproduction','P','The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism.','2013-10-27','NSRP'),(4,5,'ribosomal chaperone activity','F','OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function.','2013-10-27','NSRP'),(5,6,'high affinity zinc uptake transmembrane transporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.','2013-10-27','NSRP'),(6,7,'low-affinity zinc ion transmembrane transporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.','2013-10-27','NSRP'),(7,8,'thioredoxin','F','OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol.','2013-10-27','NSRP'),(8,9,'alpha-1,6-mannosyltransferase activity','F','Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage.','2013-10-27','NSRP'),(9,10,'trans-hexaprenyltranstransferase activity','F','Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate.','2013-10-27','NSRP'),(10,11,'vacuole inheritance','P','The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.','2013-10-27','NSRP'),(11,12,'single strand break repair','P','The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.','2013-10-27','NSRP'),(12,14,'single-stranded DNA endodeoxyribonuclease activity','F','Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.','2013-10-27','NSRP'),(13,15,'phosphopyruvate hydratase complex','C','A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water.','2013-10-27','NSRP'),(14,16,'lactase activity','F','Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose.','2013-10-27','NSRP'),(15,17,'alpha-glucoside transport','P','The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration.','2013-10-27','NSRP'),(16,18,'regulation of DNA recombination','P','Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.','2013-10-27','NSRP'),(17,19,'regulation of mitotic recombination','P','Any process that modulates the frequency, rate or extent of DNA recombination during mitosis.','2013-10-27','NSRP'),(18,20,'negative regulation of recombination within rDNA repeats','P','OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA.','2013-10-27','NSRP'),(19,22,'mitotic spindle elongation','P','Lengthening of the distance between poles of the mitotic spindle.','2013-10-27','NSRP'),(20,23,'maltose metabolic process','P','The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch.','2013-10-27','NSRP'),(21,24,'maltose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).','2013-10-27','NSRP'),(22,25,'maltose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose).','2013-10-27','NSRP'),(23,26,'alpha-1,2-mannosyltransferase activity','F','Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage.','2013-10-27','NSRP'),(24,27,'ribosomal large subunit assembly','P','The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit.','2013-10-27','NSRP'),(25,28,'ribosomal small subunit assembly','P','The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit.','2013-10-27','NSRP'),(26,30,'mannosyltransferase activity','F','Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid.','2013-10-27','NSRP'),(27,31,'mannosylphosphate transferase activity','F','Catalysis of the transfer of a mannosylphosphate group from one compound to another.','2013-10-27','NSRP'),(28,32,'cell wall mannoprotein biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.','2013-10-27','NSRP'),(29,33,'alpha-1,3-mannosyltransferase activity','F','Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage.','2013-10-27','NSRP'),(30,34,'adenine deaminase activity','F','Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3.','2013-10-27','NSRP'),(31,35,'acyl binding','F','Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.','2013-10-27','NSRP'),(32,36,'ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process','F','Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP) as part of the process of fatty acid biosynthesis.','2013-10-27','NSRP'),(33,38,'very long-chain fatty acid metabolic process','P','The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.','2013-10-27','NSRP'),(34,39,'plasma membrane long-chain fatty acid transporter','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(35,40,'low-affinity iron ion transport','P','The directed, low-affinity movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations.','2013-10-27','NSRP'),(36,41,'transition metal ion transport','P','The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.','2013-10-27','NSRP'),(37,42,'protein targeting to Golgi','P','The process of directing proteins towards the Golgi; usually uses signals contained within the protein.','2013-10-27','NSRP'),(38,44,'ascorbate stabilization','P','OBSOLETE. The reduction of the ascorbate free radical to a stable form.','2013-10-27','NSRP'),(39,45,'autophagic vacuole assembly','P','The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.','2013-10-27','NSRP'),(40,46,'autophagic vacuole fusion','P','The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole.','2013-10-27','NSRP'),(41,47,'Rieske iron-sulfur protein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(42,48,'peptidyltransferase activity','F','Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2).','2013-10-27','NSRP'),(43,49,'tRNA binding','F','Interacting selectively and non-covalently with transfer RNA.','2013-10-27','NSRP'),(44,50,'urea cycle','P','The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.','2013-10-27','NSRP'),(45,51,'urea cycle intermediate metabolic process','P','OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea.','2013-10-27','NSRP'),(46,52,'citrulline metabolic process','P','The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.','2013-10-27','NSRP'),(47,53,'argininosuccinate metabolic process','P','The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate.','2013-10-27','NSRP'),(48,54,'ribosomal subunit export from nucleus','P','The directed movement of a ribosomal subunit from the nucleus into the cytoplasm.','2013-10-27','NSRP'),(49,55,'ribosomal large subunit export from nucleus','P','The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm.','2013-10-27','NSRP'),(50,56,'ribosomal small subunit export from nucleus','P','The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm.','2013-10-27','NSRP'),(51,59,'protein import into nucleus, docking','P','A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex.','2013-10-27','NSRP'),(52,60,'protein import into nucleus, translocation','P','A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.','2013-10-27','NSRP'),(53,61,'protein import into nucleus, substrate release','P','A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex.','2013-10-27','NSRP'),(54,62,'fatty-acyl-CoA binding','F','Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group.','2013-10-27','NSRP'),(55,64,'L-ornithine transmembrane transporter activity','F','Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid.','2013-10-27','NSRP'),(56,66,'mitochondrial ornithine transport','P','The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion.','2013-10-27','NSRP'),(57,67,'DNA replication and chromosome cycle','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(58,70,'mitotic sister chromatid segregation','P','The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.','2013-10-27','NSRP'),(59,72,'M phase specific microtubule process','P','OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle.','2013-10-27','NSRP'),(60,73,'spindle pole body separation','P','A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble.','2013-10-27','NSRP'),(61,75,'cell cycle checkpoint','P','A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.','2013-10-27','NSRP'),(62,76,'DNA replication checkpoint','P','A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.','2013-10-27','NSRP'),(63,77,'DNA damage checkpoint','P','A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.','2013-10-27','NSRP'),(64,78,'cytokinesis after mitosis checkpoint','P','A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis.','2013-10-27','NSRP'),(65,79,'regulation of cyclin-dependent protein serine/threonine kinase activity','P','Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.','2013-10-27','NSRP'),(66,80,'mitotic G1 phase','P','The cell cycle \'gap\' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis.','2013-10-27','NSRP'),(67,82,'G1/S transition of mitotic cell cycle','P','The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.','2013-10-27','NSRP'),(68,83,'regulation of transcription involved in G1/S transition of mitotic cell cycle','P','Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.','2013-10-27','NSRP'),(69,84,'mitotic S phase','P','The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.','2013-10-27','NSRP'),(70,85,'mitotic G2 phase','P','The cell cycle \'gap\' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis.','2013-10-27','NSRP'),(71,86,'G2/M transition of mitotic cell cycle','P','The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.','2013-10-27','NSRP'),(72,87,'mitotic M phase','P','A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle.','2013-10-27','NSRP'),(73,88,'mitotic prophase','P','The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.','2013-10-27','NSRP'),(74,89,'mitotic metaphase','P','The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle.','2013-10-27','NSRP'),(75,90,'mitotic anaphase','P','The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle.','2013-10-27','NSRP'),(76,91,'mitotic anaphase A','P','The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis.','2013-10-27','NSRP'),(77,92,'mitotic anaphase B','P','The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis.','2013-10-27','NSRP'),(78,93,'mitotic telophase','P','The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.','2013-10-27','NSRP'),(79,94,'septin assembly and septum formation','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(80,95,'S-adenosyl-L-methionine transmembrane transporter activity','F','Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5\'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism.','2013-10-27','NSRP'),(81,96,'sulfur amino acid metabolic process','P','The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.','2013-10-27','NSRP'),(82,97,'sulfur amino acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.','2013-10-27','NSRP'),(83,98,'sulfur amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine.','2013-10-27','NSRP'),(84,99,'sulfur amino acid transmembrane transporter activity','F','Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives.','2013-10-27','NSRP'),(85,100,'S-methylmethionine transmembrane transporter activity','F','Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other.','2013-10-27','NSRP'),(86,101,'sulfur amino acid transport','P','The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(87,102,'L-methionine secondary active transmembrane transporter activity','F','Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.','2013-10-27','NSRP'),(88,103,'sulfate assimilation','P','The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds.','2013-10-27','NSRP'),(89,104,'succinate dehydrogenase activity','F','Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor.','2013-10-27','NSRP'),(90,105,'histidine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.','2013-10-27','NSRP'),(91,107,'imidazoleglycerol-phosphate synthase activity','F','Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+).','2013-10-27','NSRP'),(92,108,'repairosome','C','OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage.','2013-10-27','NSRP'),(93,109,'nucleotide-excision repair complex','C','Any complex formed of proteins that act in nucleotide-excision repair.','2013-10-27','NSRP'),(94,110,'nucleotide-excision repair factor 1 complex','C','One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively.','2013-10-27','NSRP'),(95,111,'nucleotide-excision repair factor 2 complex','C','One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p.','2013-10-27','NSRP'),(96,112,'nucleotide-excision repair factor 3 complex','C','One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p).','2013-10-27','NSRP'),(97,113,'nucleotide-excision repair factor 4 complex','C','One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p.','2013-10-27','NSRP'),(98,114,'regulation of transcription involved in G1 phase of mitotic cell cycle','P','OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle.','2013-10-27','NSRP'),(99,115,'regulation of transcription involved in S phase of mitotic cell cycle','P','OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle.','2013-10-27','NSRP'),(100,116,'regulation of transcription involved in G2-phase of mitotic cell cycle','P','OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle.','2013-10-27','NSRP'),(101,117,'regulation of transcription involved in G2/M transition of mitotic cell cycle','P','Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle.','2013-10-27','NSRP'),(102,118,'histone deacetylase complex','C','A protein complex that possesses histone deacetylase activity.','2013-10-27','NSRP'),(103,120,'RNA polymerase I transcription factor complex','C','A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I.','2013-10-27','NSRP'),(104,121,'glycerol-1-phosphatase activity','F','Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate.','2013-10-27','NSRP'),(105,122,'negative regulation of transcription from RNA polymerase II promoter','P','Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(106,123,'histone acetyltransferase complex','C','A protein complex that possesses histone acetyltransferase activity.','2013-10-27','NSRP'),(107,124,'SAGA complex','C','A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery.','2013-10-27','NSRP'),(108,125,'PCAF complex','C','A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs.','2013-10-27','NSRP'),(109,126,'transcription factor TFIIIB complex','C','A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B\'\' and BRF.','2013-10-27','NSRP'),(110,127,'transcription factor TFIIIC complex','C','A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions.','2013-10-27','NSRP'),(111,128,'flocculation','P','The reversible, calcium-dependent non-sexual aggregation of single-celled organisms.','2013-10-27','NSRP'),(112,131,'incipient cellular bud site','C','The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.','2013-10-27','NSRP'),(113,132,'establishment of mitotic spindle orientation','P','A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.','2013-10-27','NSRP'),(114,133,'polarisome','C','Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p.','2013-10-27','NSRP'),(115,135,'septin checkpoint','P','A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic cyclin-dependent kinase (CDK). In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed.','2013-05-06','NSRP'),(116,136,'alpha-1,6-mannosyltransferase complex','C','A large, multiprotein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins.','2013-10-27','NSRP'),(117,137,'Golgi cis cisterna','C','The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER.','2013-10-27','NSRP'),(118,138,'Golgi trans cisterna','C','The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed.','2013-10-27','NSRP'),(119,139,'Golgi membrane','C','The lipid bilayer surrounding any of the compartments of the Golgi apparatus.','2013-10-27','NSRP'),(120,140,'acylglycerone-phosphate reductase activity','F','Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+).','2013-10-27','NSRP'),(121,142,'cellular bud neck contractile ring','C','A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(122,144,'cellular bud neck septin ring','C','A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange.','2013-10-27','NSRP'),(123,145,'exocyst','C','A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals.','2013-10-27','NSRP'),(124,146,'microfilament motor activity','F','Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).','2013-10-27','NSRP'),(125,147,'actin cortical patch assembly','P','Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.','2013-10-27','NSRP'),(126,148,'1,3-beta-D-glucan synthase complex','C','A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain.','2013-10-27','NSRP'),(127,149,'SNARE binding','F','Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.','2013-10-27','NSRP'),(128,150,'recombinase activity','F','Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.','2013-10-27','NSRP'),(129,151,'ubiquitin ligase complex','C','A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex.','2013-10-27','NSRP'),(130,152,'nuclear ubiquitin ligase complex','C','A ubiquitin ligase complex found in the nucleus.','2013-10-27','NSRP'),(131,153,'cytoplasmic ubiquitin ligase complex','C','A ubiquitin ligase complex found in the cytoplasm.','2013-10-27','NSRP'),(132,154,'rRNA modification','P','The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.','2013-10-27','NSRP'),(133,155,'phosphorelay sensor kinase activity','F','Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response.','2013-10-27','NSRP'),(134,156,'phosphorelay response regulator activity','F','Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response.','2013-10-27','NSRP'),(135,159,'protein phosphatase type 2A complex','C','A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit.','2013-10-27','NSRP'),(136,160,'phosphorelay signal transduction system','P','A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.','2013-10-27','NSRP'),(137,161,'MAPK cascade involved in osmosensory signaling pathway','P','A MAPK cascade involved in signal transduction in response to change in osmotic conditions.','2013-10-27','NSRP'),(138,162,'tryptophan biosynthetic process','P','The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.','2013-10-27','NSRP'),(139,164,'protein phosphatase type 1 complex','C','A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase\'s substrate specificity, function, and activity.','2013-10-27','NSRP'),(140,165,'MAPK cascade','P','An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.','2013-10-27','NSRP'),(141,166,'nucleotide binding','F','Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.','2013-10-27','NSRP'),(142,167,'activation of MAPKKK activity involved in osmosensory signaling pathway','P','Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing.','2013-10-27','NSRP'),(143,168,'activation of MAPKK activity involved in osmosensory signaling pathway','P','Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing.','2013-10-27','NSRP'),(144,169,'activation of MAPK activity involved in osmosensory signaling pathway','P','Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing.','2013-10-27','NSRP'),(145,170,'sphingosine hydroxylase activity','F','Catalysis of the hydroxylation of sphingolipid long chain bases.','2013-10-27','NSRP'),(146,171,'ribonuclease MRP activity','F','Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA.','2013-10-27','NSRP'),(147,172,'ribonuclease MRP complex','C','A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication.','2013-10-27','NSRP'),(148,173,'inactivation of MAPK activity involved in osmosensory signaling pathway','P','Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing.','2013-10-27','NSRP'),(149,174,'inactivation of MAPK (mating sensu Saccharomyces)','P','OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces.','2013-10-27','NSRP'),(150,175,'3\'-5\'-exoribonuclease activity','F','Catalysis of the sequential cleavage of mononucleotides from a free 3\' terminus of an RNA molecule.','2013-10-27','NSRP'),(151,176,'nuclear exosome (RNase complex)','C','Complex of 3\'-5\' exoribonucleases found in the nucleus.','2013-10-27','NSRP'),(152,177,'cytoplasmic exosome (RNase complex)','C','Complex of 3\'-5\' exoribonucleases found in the cytoplasm.','2013-10-27','NSRP'),(153,178,'exosome (RNase complex)','C','Complex of 3\'-5\' exoribonucleases.','2013-10-27','NSRP'),(154,179,'rRNA (adenine-N6,N6-)-dimethyltransferase activity','F','Catalysis of the dimethylation two adjacent A residues in the loop closing the 3\'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor.','2013-10-27','NSRP'),(155,180,'cytosolic large ribosomal subunit','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(156,181,'cytosolic small ribosomal subunit','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(157,182,'rDNA binding','F','Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA.','2013-10-27','NSRP'),(158,183,'chromatin silencing at rDNA','P','Repression of transcription of ribosomal DNA by altering the structure of chromatin.','2013-10-27','NSRP'),(159,184,'nuclear-transcribed mRNA catabolic process, nonsense-mediated decay','P','The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.','2013-10-27','NSRP'),(160,185,'activation of MAPKKK activity','P','Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).','2013-10-27','NSRP'),(161,186,'activation of MAPKK activity','P','The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).','2013-10-27','NSRP'),(162,187,'activation of MAPK activity','P','The initiation of the activity of the inactive enzyme MAP kinase (MAPK).','2013-10-27','NSRP'),(163,188,'inactivation of MAPK activity','P','Any process that terminates the activity of the active enzyme MAP kinase.','2013-10-27','NSRP'),(164,189,'MAPK import into nucleus','P','The directed movement of a MAP kinase to the nucleus upon activation.','2013-10-27','NSRP'),(165,190,'MAPKKK cascade (pseudohyphal growth)','P','OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth.','2013-10-27','NSRP'),(166,191,'activation of MAPKKK (pseudohyphal growth)','P','OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth.','2013-10-27','NSRP'),(167,192,'activation of MAPKK (pseudohyphal growth)','P','OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth.','2013-10-27','NSRP'),(168,193,'activation of MAPK (pseudohyphal growth)','P','OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.','2013-10-27','NSRP'),(169,194,'inactivation of MAPK (pseudohyphal growth)','P','OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth.','2013-10-27','NSRP'),(170,195,'nuclear translocation of MAPK (pseudohyphal growth)','P','OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth.','2013-10-27','NSRP'),(171,196,'MAPK cascade involved in cell wall biogenesis','P','A MAPK cascade that contributes to cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.','2013-10-27','NSRP'),(172,197,'activation of MAPKKK activity involved in cell wall biogenesis','P','Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.','2013-10-27','NSRP'),(173,198,'activation of MAPKK activity involved in cell wall biogenesis','P','Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.','2013-10-27','NSRP'),(174,199,'activation of MAPK activity involved in cell wall biogenesis','P','Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.','2013-10-27','NSRP'),(175,200,'inactivation of MAPK activity involved in cell wall biogenesis','P','Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.','2013-10-27','NSRP'),(176,201,'MAPK import into nucleus involved in cell wall biogenesis','P','The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells.','2013-10-27','NSRP'),(177,202,'MAPKKK cascade during sporulation (sensu Saccharomyces)','P','OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).','2013-10-27','NSRP'),(178,203,'activation of MAPKKK during sporulation (sensu Saccharomyces)','P','OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).','2013-10-27','NSRP'),(179,204,'activation of MAPKK during sporulation (sensu Saccharomyces)','P','OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).','2013-10-27','NSRP'),(180,205,'activation of MAPK during sporulation (sensu Saccharomyces)','P','OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).','2013-10-27','NSRP'),(181,206,'inactivation of MAPK during sporulation (sensu Saccharomyces)','P','OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).','2013-10-27','NSRP'),(182,207,'nuclear translocation of MAPK during sporulation (sensu Saccharomyces)','P','OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930).','2013-10-27','NSRP'),(183,208,'MAPK import into nucleus involved in osmosensory signaling pathway','P','The directed movement of a MAP kinase to the nucleus during osmolarity sensing.','2013-10-27','NSRP'),(184,209,'protein polyubiquitination','P','Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.','2013-10-27','NSRP'),(185,210,'NAD+ diphosphatase activity','F','Catalysis of the reaction: NAD+ + H2O = AMP + NMN.','2013-10-27','NSRP'),(186,211,'protein degradation tagging activity','F','OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction.','2013-10-27','NSRP'),(187,212,'meiotic spindle organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.','2013-10-27','NSRP'),(188,213,'tRNA-intron endonuclease activity','F','Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5\'-hydroxyl and 2\',3\'-cyclic phosphate termini, and specifically removing the intron.','2013-10-27','NSRP'),(189,214,'tRNA-intron endonuclease complex','C','A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5\'-hydroxyl and 2\',3\'-cyclic phosphate termini, and specifically removing the intron.','2013-10-27','NSRP'),(190,215,'tRNA 2\'-phosphotransferase activity','F','Catalysis of the reaction: 2\'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1\'\',2\'\'-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1\'-2\' cyclic phosphate.','2013-10-27','NSRP'),(191,216,'M/G1 transition of mitotic cell cycle','P','OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle.','2013-10-27','NSRP'),(192,217,'DNA secondary structure binding','F','Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions.','2013-10-27','NSRP'),(193,219,'vacuolar hydrogen-transporting ATPase','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(194,220,'vacuolar proton-transporting V-type ATPase, V0 domain','C','The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.','2013-10-27','NSRP'),(195,221,'vacuolar proton-transporting V-type ATPase, V1 domain','C','The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane.','2013-10-27','NSRP'),(196,222,'plasma membrane proton-transporting V-type ATPase, V0 domain','C','The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane.','2013-10-27','NSRP'),(197,223,'plasma membrane proton-transporting V-type ATPase, V1 domain','C','The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane.','2013-10-27','NSRP'),(198,224,'peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity','F','Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue.','2013-10-27','NSRP'),(199,225,'N-acetylglucosaminylphosphatidylinositol deacetylase activity','F','Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane.','2013-10-27','NSRP'),(200,226,'microtubule cytoskeleton organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.','2013-10-27','NSRP'),(201,227,'oxaloacetate secondary active transmembrane transporter activity','F','Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.','2013-10-27','NSRP'),(202,228,'nuclear chromosome','C','A chromosome found in the nucleus of a eukaryotic cell.','2013-10-27','NSRP'),(203,229,'cytoplasmic chromosome','C','A chromosome found in the cytoplasm.','2013-10-27','NSRP'),(204,230,'nuclear mitotic chromosome','C','OBSOLETE. A chromosome found in the nucleus during mitosis.','2013-10-27','NSRP'),(205,231,'cytoplasmic mitotic chromosome','C','OBSOLETE. A chromosome found in the cytoplasm during mitosis.','2013-10-27','NSRP'),(206,232,'nuclear interphase chromosome','C','OBSOLETE. A chromosome found in the nucleus during interphase.','2013-10-27','NSRP'),(207,233,'cytoplasmic interphase chromosome','C','OBSOLETE. A chromosome found in the cytoplasm during interphase.','2013-10-27','NSRP'),(208,234,'phosphoethanolamine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate.','2013-10-27','NSRP'),(209,235,'astral microtubule','C','Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell.','2013-10-27','NSRP'),(210,236,'mitotic prometaphase','P','The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles.','2013-10-27','NSRP'),(211,237,'leptotene','P','The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible.','2013-10-27','NSRP'),(212,238,'zygotene','P','The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.','2013-10-27','NSRP'),(213,239,'pachytene','P','The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome.','2013-10-27','NSRP'),(214,240,'diplotene','P','The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves.','2013-10-27','NSRP'),(215,241,'diakinesis','P','The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred.','2013-10-27','NSRP'),(216,242,'pericentriolar material','C','A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome.','2013-10-27','NSRP'),(217,243,'commitment complex','C','A spliceosomal complex that is formed by association of the U1 snRNP with the 5\' splice site of an unspliced intron in an RNA transcript.','2013-10-27','NSRP'),(218,244,'assembly of spliceosomal tri-snRNP','P','The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex.','2013-10-27','NSRP'),(219,245,'spliceosomal complex assembly','P','The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.','2013-10-27','NSRP'),(220,246,'delta24(24-1) sterol reductase activity','F','Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH.','2013-10-27','NSRP'),(221,247,'C-8 sterol isomerase activity','F','Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols.','2013-10-27','NSRP'),(222,248,'C-5 sterol desaturase activity','F','Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.','2013-10-27','NSRP'),(223,249,'C-22 sterol desaturase activity','F','Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+.','2013-10-27','NSRP'),(224,250,'lanosterol synthase activity','F','Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus.','2013-10-27','NSRP'),(225,252,'C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity','F','Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H.','2013-10-27','NSRP'),(226,253,'3-keto sterol reductase activity','F','Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+).','2013-10-27','NSRP'),(227,254,'C-4 methylsterol oxidase activity','F','Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O.','2013-10-27','NSRP'),(228,255,'allantoin metabolic process','P','The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism.','2013-10-27','NSRP'),(229,256,'allantoin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea.','2013-10-27','NSRP'),(230,257,'nitrilase activity','F','Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides.','2013-10-27','NSRP'),(231,258,'isoleucine/valine:sodium symporter activity','F','OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in).','2013-10-27','NSRP'),(232,259,'intracellular nucleoside transmembrane transporter activity','F','OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell.','2013-10-27','NSRP'),(233,260,'hydrogen-translocating V-type ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria.','2013-10-27','NSRP'),(234,261,'sodium-translocating V-type ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria.','2013-10-27','NSRP'),(235,262,'mitochondrial chromosome','C','A chromosome found in the mitochondrion of a eukaryotic cell.','2013-10-27','NSRP'),(236,263,'heterotrimeric G-protein GTPase, alpha-subunit','F','OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity.','2013-10-27','NSRP'),(237,264,'heterotrimeric G-protein GTPase, beta-subunit','F','OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit.','2013-10-27','NSRP'),(238,265,'heterotrimeric G-protein GTPase, gamma-subunit','F','OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit.','2013-10-27','NSRP'),(239,266,'mitochondrial fission','P','The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.','2013-10-27','NSRP'),(240,267,'cell fraction','C','OBSOLETE: A generic term for parts of cells prepared by disruptive biochemical techniques.','2013-10-27','NSRP'),(241,268,'peroxisome targeting sequence binding','F','Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome.','2013-10-27','NSRP'),(242,269,'toxin export channel activity','F','Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.','2013-10-27','NSRP'),(243,270,'peptidoglycan metabolic process','P','The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network.','2013-10-27','NSRP'),(244,271,'polysaccharide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.','2013-10-27','NSRP'),(245,272,'polysaccharide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.','2013-10-27','NSRP'),(246,274,'mitochondrial proton-transporting ATP synthase, stator stalk','C','One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core.','2013-10-27','NSRP'),(247,275,'mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)','C','The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled.','2013-10-27','NSRP'),(248,276,'mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)','C','All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins.','2013-10-27','NSRP'),(249,277,'[cytochrome c]-lysine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c.','2013-10-27','NSRP'),(250,278,'mitotic cell cycle','P','Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.','2013-10-27','NSRP'),(251,279,'M phase','P','A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase.','2013-10-27','NSRP'),(252,280,'nuclear division','P','The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.','2013-10-27','NSRP'),(253,281,'mitotic cytokinesis','P','A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.','2013-10-27','NSRP'),(254,282,'cellular bud site selection','P','The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(255,284,'shmoo orientation','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(256,285,'1-phosphatidylinositol-3-phosphate 5-kinase activity','F','Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(257,286,'alanine dehydrogenase activity','F','Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+).','2013-10-27','NSRP'),(258,287,'magnesium ion binding','F','Interacting selectively and non-covalently with magnesium (Mg) ions.','2013-10-27','NSRP'),(259,288,'nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay','P','A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.','2013-10-27','NSRP'),(260,289,'nuclear-transcribed mRNA poly(A) tail shortening','P','Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.','2013-10-27','NSRP'),(261,290,'deadenylation-dependent decapping of nuclear-transcribed mRNA','P','Cleavage of the 5\'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.','2013-10-27','NSRP'),(262,291,'nuclear-transcribed mRNA catabolic process, exonucleolytic','P','The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5\'-cap or the 3\'-poly(A) tail.','2013-10-27','NSRP'),(263,292,'RNA fragment catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing.','2013-10-27','NSRP'),(264,293,'ferric-chelate reductase activity','F','Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+).','2013-10-27','NSRP'),(265,294,'nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay','P','A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends.','2013-10-27','NSRP'),(266,295,'adenine nucleotide transmembrane transporter activity','F','Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other.','2013-10-27','NSRP'),(267,296,'spermine transport','P','The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(268,297,'spermine transmembrane transporter activity','F','Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.','2013-10-27','NSRP'),(269,298,'endopolyphosphatase activity','F','Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues.','2013-10-27','NSRP'),(270,299,'integral to membrane of membrane fraction','C','OBSOLETE: Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes.','2013-10-27','NSRP'),(271,300,'peripheral to membrane of membrane fraction','C','OBSOLETE: Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH.','2013-10-27','NSRP'),(272,301,'retrograde transport, vesicle recycling within Golgi','P','The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi.','2013-10-27','NSRP'),(273,302,'response to reactive oxygen species','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.','2013-10-27','NSRP'),(274,303,'response to superoxide','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.','2013-10-27','NSRP'),(275,304,'response to singlet oxygen','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst.','2013-10-27','NSRP'),(276,305,'response to oxygen radical','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion.','2013-10-27','NSRP'),(277,306,'extrinsic to vacuolar membrane','C','Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(278,307,'cyclin-dependent protein kinase holoenzyme complex','C','Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner.','2013-10-27','NSRP'),(279,308,'cytoplasmic cyclin-dependent protein kinase holoenzyme complex','C','Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.','2013-10-27','NSRP'),(280,309,'nicotinamide-nucleotide adenylyltransferase activity','F','Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+.','2013-10-27','NSRP'),(281,310,'xanthine phosphoribosyltransferase activity','F','Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5\'-phosphate + diphosphate.','2013-10-27','NSRP'),(282,311,'plastid large ribosomal subunit','C','The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).','2013-10-27','NSRP'),(283,312,'plastid small ribosomal subunit','C','The smaller of the two subunits of a plastid ribosome.','2013-10-27','NSRP'),(284,313,'organellar ribosome','C','A ribosome contained within a subcellular membrane-bounded organelle.','2013-10-27','NSRP'),(285,314,'organellar small ribosomal subunit','C','The smaller of the two subunits of an organellar ribosome.','2013-10-27','NSRP'),(286,315,'organellar large ribosomal subunit','C','The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site).','2013-10-27','NSRP'),(287,316,'sulfite transport','P','The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(288,318,'protein-methionine-R-oxide reductase activity','F','Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.','2012-03-14','NSRP'),(289,319,'sulfite transmembrane transporter activity','F','Catalysis of the transfer of sulfite ions from one side of a membrane to the other.','2013-10-27','NSRP'),(290,320,'re-entry into mitotic cell cycle','P','The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state.','2013-10-27','NSRP'),(291,321,'re-entry into mitotic cell cycle after pheromone arrest','P','The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(292,322,'storage vacuole','C','A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules.','2013-10-27','NSRP'),(293,323,'lytic vacuole','C','A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.','2013-10-27','NSRP'),(294,324,'fungal-type vacuole','C','A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure.','2013-10-27','NSRP'),(295,325,'plant-type vacuole','C','A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(296,326,'protein storage vacuole','C','A storage vacuole that contains a lytic vacuole; identified in plants.','2013-10-27','NSRP'),(297,327,'lytic vacuole within protein storage vacuole','C','A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole.','2013-10-27','NSRP'),(298,328,'fungal-type vacuole lumen','C','The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(299,329,'fungal-type vacuole membrane','C','The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(300,330,'plant-type vacuole lumen','C','The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(301,331,'contractile vacuole','C','A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory.','2013-10-27','NSRP'),(302,332,'template for synthesis of G-rich strand of telomere DNA activity','F','Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA.','2013-10-27','NSRP'),(303,333,'telomerase catalytic core complex','C','The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition.','2013-10-27','NSRP'),(304,334,'3-hydroxyanthranilate 3,4-dioxygenase activity','F','Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+).','2013-10-27','NSRP'),(305,335,'negative regulation of transposition, DNA-mediated','P','Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition.','2013-10-27','NSRP'),(306,336,'positive regulation of transposition, DNA-mediated','P','Any process that activates or increases the frequency, rate or extent of DNA transposition.','2013-10-27','NSRP'),(307,337,'regulation of transposition, DNA-mediated','P','Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule.','2013-10-27','NSRP'),(308,338,'protein deneddylation','P','The removal of a ubiquitin-like protein of the NEDD8 type from a protein.','2013-10-27','NSRP'),(309,339,'RNA cap binding','F','Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5\' end of an RNA molecule.','2013-10-27','NSRP'),(310,340,'RNA 7-methylguanosine cap binding','F','Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5\' end of RNA molecules transcribed by polymerase II.','2013-10-27','NSRP'),(311,341,'RNA trimethylguanosine cap binding','F','Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5\' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans.','2013-10-27','NSRP'),(312,342,'RNA cap 4 binding','F','Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2\'-O-trimethyladenosine-p-2\'-O-methyladenosine-p-2\'-O-methylcytosine-p-N3, 2\'-O-dimethyluridine Such caps are known to be found at the 5\' ends of SL RNAs of trypanosomatid protozoa.','2013-10-27','NSRP'),(313,343,'plastid-encoded plastid RNA polymerase complex A','C','A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex.','2013-10-27','NSRP'),(314,344,'plastid-encoded plastid RNA polymerase complex B','C','A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation.','2013-10-27','NSRP'),(315,345,'cytosolic DNA-directed RNA polymerase complex','C','The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity.','2013-10-27','NSRP'),(316,346,'transcription export complex','C','The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans.','2013-10-27','NSRP'),(317,347,'THO complex','C','The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits.','2013-10-27','NSRP'),(318,348,'mRNA branch site recognition','P','Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome.','2013-10-27','NSRP'),(319,349,'generation of catalytic spliceosome for first transesterification step','P','Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome.','2013-10-27','NSRP'),(320,350,'generation of catalytic spliceosome for second transesterification step','P','Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.','2013-10-27','NSRP'),(321,352,'trans assembly of SL-containing precatalytic spliceosome','P','Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA.','2013-10-27','NSRP'),(322,353,'formation of quadruple SL/U4/U5/U6 snRNP','P','Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5\' splice site within the SL RNA.','2013-10-27','NSRP'),(323,354,'cis assembly of pre-catalytic spliceosome','P','Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner.','2013-10-27','NSRP'),(324,362,'first U2-type spliceosomal transesterification activity','F','OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5\' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3\' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins.','2013-10-27','NSRP'),(325,363,'first U12-type spliceosomal transesterification activity','F','OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5\' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3\' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins.','2013-10-27','NSRP'),(326,364,'second U2-type spliceosomal transesterification activity','F','OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3\'-hydroxyl group of the 5\' exon is the nucleophile attacking the 3\' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins.','2013-10-27','NSRP'),(327,365,'mRNA trans splicing, via spliceosome','P','The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.','2013-10-27','NSRP'),(328,366,'intergenic mRNA trans splicing','P','The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing.','2013-10-27','NSRP'),(329,367,'second U12-type spliceosomal transesterification activity','F','OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3\'-hydroxyl group of the 5\' exon is the nucleophile attacking the 3\' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins.','2013-10-27','NSRP'),(330,372,'Group I intron splicing','P','The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize).','2013-10-27','NSRP'),(331,373,'Group II intron splicing','P','The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat.','2013-10-27','NSRP'),(332,374,'Group III intron splicing','P','The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved.','2013-10-27','NSRP'),(333,375,'RNA splicing, via transesterification reactions','P','Splicing of RNA via a series of two transesterification reactions.','2013-10-27','NSRP'),(334,376,'RNA splicing, via transesterification reactions with guanosine as nucleophile','P','Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile.','2013-10-27','NSRP'),(335,377,'RNA splicing, via transesterification reactions with bulged adenosine as nucleophile','P','Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure.','2013-10-27','NSRP'),(336,378,'RNA exon ligation','P','The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction.','2013-10-27','NSRP'),(337,379,'tRNA-type intron splice site recognition and cleavage','P','RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5\' and 3\' splice sites occurs.','2013-10-27','NSRP'),(338,380,'alternative mRNA splicing, via spliceosome','P','The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition.','2013-10-27','NSRP'),(339,381,'regulation of alternative mRNA splicing, via spliceosome','P','Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.','2013-10-27','NSRP'),(340,384,'first spliceosomal transesterification activity','F','Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5\' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3\' exon.','2013-10-27','NSRP'),(341,386,'second spliceosomal transesterification activity','F','Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3\'-hydroxyl group of the 5\' exon is the nucleophile attacking the 3\' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure.','2013-10-27','NSRP'),(342,387,'spliceosomal snRNP assembly','P','The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome.','2013-10-27','NSRP'),(343,388,'spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)','P','Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11).','2013-10-27','NSRP'),(344,389,'mRNA 3\'-splice site recognition','P','Recognition of the intron 3\'-splice site by components of the assembling U2- or U12-type spliceosome.','2013-10-27','NSRP'),(345,390,'spliceosomal complex disassembly','P','Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure.','2013-10-27','NSRP'),(346,393,'spliceosomal conformational changes to generate catalytic conformation','P','Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation.','2013-10-27','NSRP'),(347,394,'RNA splicing, via endonucleolytic cleavage and ligation','P','Splicing of RNA via recognition of the folded RNA structure that brings the 5\' and 3\' splice sites into proximity and cleavage of the RNA at both the 3\' and 5\' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.','2013-10-27','NSRP'),(348,395,'mRNA 5\'-splice site recognition','P','Recognition of the intron 5\'-splice site by components of the assembling spliceosome.','2013-10-27','NSRP'),(349,398,'mRNA splicing, via spliceosome','P','The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.','2013-10-27','NSRP'),(350,399,'cellular bud neck septin structure','C','Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle.','2013-10-27','NSRP'),(351,400,'four-way junction DNA binding','F','Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices.','2013-10-27','NSRP'),(352,401,'open form four-way junction DNA binding','F','Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over.','2013-10-27','NSRP'),(353,402,'crossed form four-way junction DNA binding','F','Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands.','2013-10-27','NSRP'),(354,403,'Y-form DNA binding','F','Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end.','2013-10-27','NSRP'),(355,404,'loop DNA binding','F','Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration.','2013-10-27','NSRP'),(356,405,'bubble DNA binding','F','Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA.','2013-10-27','NSRP'),(357,406,'double-strand/single-strand DNA junction binding','F','Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA.','2013-10-27','NSRP'),(358,407,'pre-autophagosomal structure','C','A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes.','2013-10-27','NSRP'),(359,408,'EKC/KEOPS complex','C','A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p.','2013-10-27','NSRP'),(360,409,'regulation of transcription by galactose','P','Any process involving galactose that modulates the frequency, rate or extent or transcription.','2013-10-27','NSRP'),(361,410,'negative regulation of transcription by galactose','P','Any process involving galactose that stops, prevents or reduces the rate of transcription.','2013-10-27','NSRP'),(362,411,'positive regulation of transcription by galactose','P','Any process involving galactose that activates or increases the rate of transcription.','2013-10-27','NSRP'),(363,412,'histone peptidyl-prolyl isomerization','P','The modification of a histone by cis-trans isomerization of a proline residue.','2013-10-27','NSRP'),(364,413,'protein peptidyl-prolyl isomerization','P','The modification of a protein by cis-trans isomerization of a proline residue.','2013-10-27','NSRP'),(365,414,'regulation of histone H3-K36 methylation','P','Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.','2013-10-27','NSRP'),(366,415,'negative regulation of histone H3-K36 methylation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.','2013-10-27','NSRP'),(367,416,'positive regulation of histone H3-K36 methylation','P','Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3.','2013-10-27','NSRP'),(368,417,'HIR complex','C','A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p.','2013-10-27','NSRP'),(369,418,'DNA-directed RNA polymerase IV complex','C','RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex.','2013-10-27','NSRP'),(370,419,'DNA-directed RNA polymerase V complex','C','RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits.','2013-10-27','NSRP'),(371,421,'autophagic vacuole membrane','C','The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered.','2013-10-27','NSRP'),(372,422,'mitochondrion degradation','P','The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.','2013-10-27','NSRP'),(373,423,'macromitophagy','P','Degradation of a mitochondrion by macroautophagy.','2013-10-27','NSRP'),(374,424,'micromitophagy','P','Degradation of a mitochondrion by microautophagy.','2013-10-27','NSRP'),(375,425,'macropexophagy','P','Degradation of a peroxisome by macropexophagy.','2013-10-27','NSRP'),(376,426,'micropexophagy','P','Degradation of a peroxisome by micropexophagy.','2013-10-27','NSRP'),(377,427,'plastid-encoded plastid RNA polymerase complex','C','An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition.','2013-10-27','NSRP'),(378,428,'DNA-directed RNA polymerase complex','C','A protein complex that possesses DNA-directed RNA polymerase activity.','2013-10-27','NSRP'),(379,429,'carbon catabolite regulation of transcription from RNA polymerase II promoter','P','A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.','2013-10-27','NSRP'),(380,430,'regulation of transcription from RNA polymerase II promoter by glucose','P','Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(381,431,'regulation of transcription from RNA polymerase II promoter by galactose','P','Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(382,432,'positive regulation of transcription from RNA polymerase II promoter by glucose','P','Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(383,433,'negative regulation of transcription from RNA polymerase II promoter by glucose','P','Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(384,434,'negative regulation of transcription from RNA polymerase II promoter by galactose','P','Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(385,435,'positive regulation of transcription from RNA polymerase II promoter by galactose','P','Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(386,436,'carbon catabolite activation of transcription from RNA polymerase II promoter','P','Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(387,437,'carbon catabolite repression of transcription from RNA polymerase II promoter','P','A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources.','2013-10-27','NSRP'),(388,438,'core TFIIH complex portion of holo TFIIH complex','C','The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34.','2013-10-27','NSRP'),(389,439,'core TFIIH complex','C','The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34.','2013-10-27','NSRP'),(390,440,'core TFIIH complex portion of NEF3 complex','C','The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34.','2013-10-27','NSRP'),(391,441,'SSL2-core TFIIH complex','C','A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.','2013-10-27','NSRP'),(392,442,'SSL2-core TFIIH complex portion of NEF3 complex','C','The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.','2013-10-27','NSRP'),(393,443,'SSL2-core TFIIH complex portion of holo TFIIH complex','C','The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB.','2013-10-27','NSRP'),(394,444,'MIS12/MIND type complex','C','A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1.','2013-10-27','NSRP'),(395,445,'THO complex part of transcription export complex','C','The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.','2013-10-27','NSRP'),(396,446,'nucleoplasmic THO complex','C','The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits.','2013-10-27','NSRP'),(397,447,'endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(398,448,'cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(399,449,'endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)','P','Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5\' to 3\' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.','2013-10-27','NSRP'),(400,450,'cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA)','P','Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5\' to 3\' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species.','2013-10-27','NSRP'),(401,451,'rRNA 2\'-O-methylation','P','The addition of a methyl group to the 2\'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis.','2013-10-27','NSRP'),(402,452,'snoRNA guided rRNA 2\'-O-methylation','P','The posttranscriptional addition of methyl groups to the 2\'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation.','2013-10-27','NSRP'),(403,453,'enzyme-directed rRNA 2\'-O-methylation','P','The addition of methyl groups to the 2\'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA.','2013-10-27','NSRP'),(404,454,'snoRNA guided rRNA pseudouridine synthesis','P','The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation.','2013-10-27','NSRP'),(405,455,'enzyme-directed rRNA pseudouridine synthesis','P','The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.','2013-10-27','NSRP'),(406,456,'dimethylation involved in SSU-rRNA maturation','P','Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3\'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes.','2013-10-27','NSRP'),(407,457,'endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)','P','Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5\' to 3\' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.','2013-10-27','NSRP'),(408,458,'endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S)','P','Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5\' to 3\' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.','2013-10-27','NSRP'),(409,459,'exonucleolytic trimming involved in rRNA processing','P','Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule.','2013-10-27','NSRP'),(410,460,'maturation of 5.8S rRNA','P','Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.','2013-10-27','NSRP'),(411,461,'endonucleolytic cleavage to generate mature 3\'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage at the 3\'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5\' to 3\' along the primary transcript, to produce the mature end of the SSU-rRNA.','2013-10-27','NSRP'),(412,462,'maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(413,463,'maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(414,464,'endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5\' to 3\' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs.','2013-10-27','NSRP'),(415,465,'exonucleolytic trimming to generate mature 5\'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5\'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(416,466,'maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(417,467,'exonucleolytic trimming to generate mature 3\'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3\'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(418,468,'generation of mature 3\'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Any process involved in generating the mature 3\'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(419,469,'cleavage involved in rRNA processing','P','Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule.','2013-10-27','NSRP'),(420,470,'maturation of LSU-rRNA','P','Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule.','2013-10-27','NSRP'),(421,471,'endonucleolytic cleavage in 3\'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage within the 3\'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5\' to 3\' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3\'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events.','2013-10-27','NSRP'),(422,472,'endonucleolytic cleavage to generate mature 5\'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage between the 5\'-External Transcribed Spacer (5\'-ETS) and the 5\' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5\' to 3\' along the primary transcript, to produce the mature end of the SSU-rRNA.','2013-10-27','NSRP'),(423,473,'maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)','P','Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(424,474,'maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)','P','Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(425,475,'maturation of 2S rRNA','P','Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule.','2013-10-27','NSRP'),(426,476,'maturation of 4.5S rRNA','P','Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule.','2013-10-27','NSRP'),(427,477,'generation of mature 5\'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Cleavage within ITS2 to generate the mature 5\'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(428,478,'endonucleolytic cleavage involved in rRNA processing','P','Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA.','2013-10-27','NSRP'),(429,479,'endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae.','2013-10-27','NSRP'),(430,480,'endonucleolytic cleavage in 5\'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage within the 5\'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5\' to 3\' along the primary transcript. Endonucleolytic cleavage within the 5\'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable.','2013-10-27','NSRP'),(431,481,'maturation of 5S rRNA','P','Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule.','2013-10-27','NSRP'),(432,482,'maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)','P','Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(433,483,'endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species.','2013-10-27','NSRP'),(434,484,'cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(435,485,'cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(436,486,'cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)','P','Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(437,487,'maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA)','P','Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(438,488,'maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)','P','Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(439,489,'maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)','P','Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(440,491,'small nucleolar ribonucleoprotein complex assembly','P','The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex.','2013-10-27','NSRP'),(441,492,'box C/D snoRNP assembly','P','The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.','2013-10-27','NSRP'),(442,493,'box H/ACA snoRNP assembly','P','The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex.','2013-10-27','NSRP'),(443,494,'box C/D snoRNA 3\'-end processing','P','Any process involved in forming the mature 3\' end of a box C/D snoRNA molecule.','2013-10-27','NSRP'),(444,495,'box H/ACA snoRNA 3\'-end processing','P','Any process involved in forming the mature 3\' end of a box H/ACA snoRNA molecule.','2013-10-27','NSRP'),(445,496,'base pairing','F','Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule.','2013-10-27','NSRP'),(446,497,'base pairing with DNA','F','Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule.','2013-10-27','NSRP'),(447,498,'base pairing with RNA','F','Interacting selectively and non-covalently with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule.','2013-10-27','NSRP'),(448,499,'base pairing with mRNA','F','Interacting selectively and non-covalently with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule.','2013-10-27','NSRP'),(449,500,'RNA polymerase I upstream activating factor complex','C','A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p.','2013-10-27','NSRP'),(450,501,'flocculation via cell wall protein-carbohydrate interaction','P','The non-sexual aggregation of cells mediated by protein (flocculin)-carbohydrate interaction present in the cell wall. This process is pH- and calcium-dependent and reversible. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(451,502,'proteasome complex','C','A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core.','2013-10-27','NSRP'),(452,504,'proteasome regulatory particle (sensu Bacteria)','C','OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2).','2013-10-27','NSRP'),(453,506,'glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex','C','An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast.','2013-10-27','NSRP'),(454,578,'embryonic axis specification','P','The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.','2013-10-27','NSRP'),(455,700,'mismatch base pair DNA N-glycosylase activity','F','Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1\' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.','2013-10-27','NSRP'),(456,701,'purine-specific mismatch base pair DNA N-glycosylase activity','F','Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1\' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.','2013-10-27','NSRP'),(457,702,'oxidized base lesion DNA N-glycosylase activity','F','Catalysis of the removal of oxidized bases by cleaving the N-C1\' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.','2013-10-27','NSRP'),(458,703,'oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity','F','Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1\' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3\' of the apyrimidinic (AP) site.','2013-10-27','NSRP'),(459,704,'pyrimidine dimer DNA N-glycosylase activity','F','Catalysis of the removal of pyrimidine dimers by removing the 5\' pyrimidine of the dimer by cleaving the N-C1\' glycosidic bond between the 5\' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5\' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3\' of the apyrimidinic (AP) site.','2013-10-27','NSRP'),(460,705,'achiasmate meiosis I','P','The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata.','2013-10-27','NSRP'),(461,706,'meiotic DNA double-strand break processing','P','The cell cycle process in which the 5\' to 3\' exonucleolytic resection of the DNA at the site of the break to form a 3\' single-strand DNA overhang occurs. This takes place during meiosis.','2013-10-27','NSRP'),(462,707,'meiotic DNA recombinase assembly','P','During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA.','2013-10-27','NSRP'),(463,708,'meiotic strand invasion','P','The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis.','2013-10-27','NSRP'),(464,709,'meiotic joint molecule formation','P','The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA.','2013-10-27','NSRP'),(465,710,'meiotic mismatch repair','P','A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis.','2013-10-27','NSRP'),(466,711,'meiotic DNA repair synthesis','P','During meiosis, the synthesis of DNA proceeding from the broken 3\' single-strand DNA end that uses the homologous intact duplex as the template.','2013-10-27','NSRP'),(467,712,'resolution of meiotic recombination intermediates','P','The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged.','2013-10-27','NSRP'),(468,713,'meiotic heteroduplex formation','P','During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.','2013-10-27','NSRP'),(469,714,'meiotic strand displacement','P','The cell cycle process in which the broken 3\' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3\' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis.','2013-10-27','NSRP'),(470,715,'nucleotide-excision repair, DNA damage recognition','P','The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix.','2013-10-27','NSRP'),(471,716,'transcription-coupled nucleotide-excision repair, DNA damage recognition','P','The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway.','2013-10-27','NSRP'),(472,717,'nucleotide-excision repair, DNA duplex unwinding','P','The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage.','2013-10-27','NSRP'),(473,718,'nucleotide-excision repair, DNA damage removal','P','The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage.','2013-10-27','NSRP'),(474,719,'photoreactive repair','P','The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines.','2013-10-27','NSRP'),(475,720,'pyrimidine dimer repair by nucleotide-excision repair','P','The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.','2013-10-27','NSRP'),(476,721,'(R,R)-butanediol dehydrogenase activity','F','Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+).','2013-10-27','NSRP'),(477,722,'telomere maintenance via recombination','P','Any recombinational process that contributes to the maintenance of proper telomeric length.','2013-10-27','NSRP'),(478,723,'telomere maintenance','P','Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences.','2013-10-27','NSRP'),(479,724,'double-strand break repair via homologous recombination','P','The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.','2013-10-27','NSRP'),(480,725,'recombinational repair','P','A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.','2013-10-27','NSRP'),(481,726,'non-recombinational repair','P','A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA.','2013-10-27','NSRP'),(482,727,'double-strand break repair via break-induced replication','P','The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3\' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.','2013-10-27','NSRP'),(483,728,'gene conversion at mating-type locus, DNA double-strand break formation','P','The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another.','2013-10-27','NSRP'),(484,729,'DNA double-strand break processing','P','The 5\' to 3\' exonucleolytic resection of the DNA at the site of the break to form a 3\' single-strand DNA overhang.','2013-10-27','NSRP'),(485,730,'DNA recombinase assembly','P','The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA.','2013-10-27','NSRP'),(486,731,'DNA synthesis involved in DNA repair','P','Synthesis of DNA that proceeds from the broken 3\' single-strand DNA end uses the homologous intact duplex as the template.','2013-10-27','NSRP'),(487,732,'strand displacement','P','The rejection of the broken 3\' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3\' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules.','2013-10-27','NSRP'),(488,733,'DNA strand renaturation','P','The identification and annealing of complementary base pairs in single-strand DNA.','2013-10-27','NSRP'),(489,734,'gene conversion at mating-type locus, DNA repair synthesis','P','Synthesis of DNA that proceeds from the broken 3\' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus.','2013-10-27','NSRP'),(490,735,'removal of nonhomologous ends','P','The removal of nonhomologous sequences at the broken 3\' single-strand DNA end before DNA repair synthesis can occur.','2013-10-27','NSRP'),(491,736,'double-strand break repair via single-strand annealing, removal of nonhomologous ends','P','During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3\' single-strand DNA end before DNA repair synthesis can occur.','2013-10-27','NSRP'),(492,737,'DNA catabolic process, endonucleolytic','P','The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3\',5\'-phosphodiester bonds in one or two strands of deoxyribonucleotides.','2013-10-27','NSRP'),(493,738,'DNA catabolic process, exonucleolytic','P','The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3\',5\'-phosphodiester bonds in one or two strands of deoxyribonucleotides.','2013-10-27','NSRP'),(494,739,'DNA strand annealing activity','F','OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA.','2013-10-27','NSRP'),(495,740,'nuclear membrane fusion','P','The joining of 2 or more lipid bilayer membranes that surround the nucleus.','2013-10-27','NSRP'),(496,741,'karyogamy','P','The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.','2013-10-27','NSRP'),(497,742,'karyogamy involved in conjugation with cellular fusion','P','During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy.','2013-10-27','NSRP'),(498,743,'nuclear migration involved in conjugation with cellular fusion','P','The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion.','2013-10-27','NSRP'),(499,744,'karyogamy involved in conjugation with mutual genetic exchange','P','During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei.','2013-10-27','NSRP'),(500,745,'nuclear migration involved in conjugation with mutual genetic exchange','P','The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion.','2013-10-27','NSRP'),(501,746,'conjugation','P','The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms.','2013-10-27','NSRP'),(502,747,'conjugation with cellular fusion','P','A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(503,748,'conjugation with mutual genetic exchange','P','A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange.','2013-10-27','NSRP'),(504,749,'response to pheromone involved in conjugation with cellular fusion','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(505,750,'pheromone-dependent signal transduction involved in conjugation with cellular fusion','P','A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(506,751,'cell cycle arrest in response to pheromone','P','The cell cycle regulatory process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(507,752,'agglutination involved in conjugation with cellular fusion','P','During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(508,753,'cell morphogenesis involved in conjugation with cellular fusion','P','The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion.','2013-10-27','NSRP'),(509,754,'adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion','P','In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(510,755,'cytogamy','P','During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(511,756,'response to pheromone involved in conjugation with mutual genetic exchange','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion.','2013-10-27','NSRP'),(512,757,'signal transduction involved in conjugation with mutual genetic exchange','P','A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion.','2013-10-27','NSRP'),(513,758,'agglutination involved in conjugation with mutual genetic exchange','P','During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions.','2013-10-27','NSRP'),(514,759,'cell morphogenesis involved in conjugation with mutual genetic exchange','P','The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion.','2013-10-27','NSRP'),(515,760,'adaptation to pheromone involved in conjugation with mutual genetic exchange','P','In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses.','2013-10-27','NSRP'),(516,761,'conjugant formation','P','During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing.','2013-10-27','NSRP'),(517,762,'pheromone-induced unidirectional conjugation','P','The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell (\'male\') is then transferred into the other cell (\'female\'); unidirectional conjugation occurs between cells of different mating types.','2013-10-27','NSRP'),(518,763,'cell morphogenesis involved in unidirectional conjugation','P','OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation.','2013-10-27','NSRP'),(519,764,'cellular morphogenesis involved in pheromone-induced unidirectional conjugation','P','OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation.','2013-10-27','NSRP'),(520,765,'response to pheromone involved in pheromone-induced unidirectional conjugation','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of pheromone-induced unidirectional conjugation.','2013-10-27','NSRP'),(521,766,'negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation','P','In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses.','2013-10-27','NSRP'),(522,767,'cell morphogenesis involved in conjugation','P','The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types.','2013-10-27','NSRP'),(523,768,'syncytium formation by plasma membrane fusion','P','The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.','2013-10-27','NSRP'),(524,769,'syncytium formation by mitosis without cytokinesis','P','The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis.','2013-10-27','NSRP'),(525,770,'peptide pheromone export','P','The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones.','2013-10-27','NSRP'),(526,771,'agglutination involved in conjugation','P','The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation.','2013-10-27','NSRP'),(527,772,'mating pheromone activity','F','The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted.','2013-10-27','NSRP'),(528,773,'phosphatidyl-N-methylethanolamine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine.','2013-10-27','NSRP'),(529,774,'adenyl-nucleotide exchange factor activity','F','Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins.','2013-10-27','NSRP'),(530,775,'chromosome, centromeric region','C','The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.','2013-10-27','NSRP'),(531,776,'kinetochore','C','A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.','2013-10-27','NSRP'),(532,777,'condensed chromosome kinetochore','C','A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules.','2013-10-27','NSRP'),(533,778,'condensed nuclear chromosome kinetochore','C','A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules.','2013-10-27','NSRP'),(534,779,'condensed chromosome, centromeric region','C','The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.','2013-10-27','NSRP'),(535,780,'condensed nuclear chromosome, centromeric region','C','The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.','2013-10-27','NSRP'),(536,781,'chromosome, telomeric region','C','The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins.','2013-10-27','NSRP'),(537,782,'telomere cap complex','C','A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome.','2013-10-27','NSRP'),(538,783,'nuclear telomere cap complex','C','A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome.','2013-10-27','NSRP'),(539,784,'nuclear chromosome, telomeric region','C','The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins.','2013-10-27','NSRP'),(540,785,'chromatin','C','The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.','2013-10-27','NSRP'),(541,786,'nucleosome','C','A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.','2013-10-27','NSRP'),(542,787,'cytoplasmic nucleosome','C','A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures.','2013-10-27','NSRP'),(543,788,'nuclear nucleosome','C','A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures.','2013-10-27','NSRP'),(544,789,'cytoplasmic chromatin','C','The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the cytoplasm.','2013-10-27','NSRP'),(545,790,'nuclear chromatin','C','The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.','2013-10-27','NSRP'),(546,791,'euchromatin','C','A dispersed and relatively uncompacted form of chromatin.','2013-10-27','NSRP'),(547,792,'heterochromatin','C','A compact and highly condensed form of chromatin.','2013-10-27','NSRP'),(548,793,'condensed chromosome','C','A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.','2013-10-27','NSRP'),(549,794,'condensed nuclear chromosome','C','A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus.','2013-10-27','NSRP'),(550,795,'synaptonemal complex','C','A proteinaceous scaffold found between homologous chromosomes during meiosis.','2013-10-27','NSRP'),(551,796,'condensin complex','C','A multisubunit protein complex that plays a central role in chromosome condensation.','2013-10-27','NSRP'),(552,797,'condensin core heterodimer','C','The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation.','2013-10-27','NSRP'),(553,798,'nuclear cohesin complex','C','A cohesin complex required for cohesion between sister chromatids that remain in the nucleus.','2013-10-27','NSRP'),(554,799,'nuclear condensin complex','C','A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus.','2013-10-27','NSRP'),(555,800,'lateral element','C','A proteinaceous core found between sister chromatids during meiotic prophase.','2013-10-27','NSRP'),(556,801,'central element','C','A structural unit of the synaptonemal complex found between the lateral elements.','2013-10-27','NSRP'),(557,802,'transverse filament','C','A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them.','2013-10-27','NSRP'),(558,803,'sex chromosome','C','A chromosome involved in sex determination.','2013-10-27','NSRP'),(559,804,'W chromosome','C','The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females.','2013-10-27','NSRP'),(560,805,'X chromosome','C','The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males.','2013-10-27','NSRP'),(561,806,'Y chromosome','C','The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.','2013-10-27','NSRP'),(562,807,'Z chromosome','C','The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females.','2013-10-27','NSRP'),(563,808,'origin recognition complex','C','A multisubunit complex that is located at the replication origins of a chromosome.','2013-10-27','NSRP'),(564,809,'cytoplasmic origin of replication recognition complex','C','A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm.','2013-10-27','NSRP'),(565,810,'diacylglycerol diphosphate phosphatase activity','F','Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate.','2013-10-27','NSRP'),(566,811,'GINS complex','C','A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks.','2013-10-27','NSRP'),(567,812,'Swr1 complex','C','A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits.','2013-10-27','NSRP'),(568,813,'ESCRT I complex','C','An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.','2013-10-27','NSRP'),(569,814,'ESCRT II complex','C','An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes.','2013-10-27','NSRP'),(570,815,'ESCRT III complex','C','An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes.','2013-10-27','NSRP'),(571,817,'COMA complex','C','A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly.','2013-10-27','NSRP'),(572,818,'nuclear MIS12/MIND complex','C','A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1.','2013-10-27','NSRP'),(573,819,'sister chromatid segregation','P','The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.','2013-10-27','NSRP'),(574,820,'regulation of glutamine family amino acid metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.','2013-10-27','NSRP'),(575,821,'regulation of arginine metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid.','2013-10-27','NSRP'),(576,822,'inositol hexakisphosphate binding','F','Interacting selectively and non-covalently with inositol hexakisphosphate.','2013-10-27','NSRP'),(577,823,'inositol-1,4,5-trisphosphate 6-kinase activity','F','Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(578,824,'inositol tetrakisphosphate 3-kinase activity','F','Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.','2013-10-27','NSRP'),(579,825,'inositol tetrakisphosphate 6-kinase activity','F','Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP.','2013-10-27','NSRP'),(580,826,'inositol pyrophosphate synthase activity','F','OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds.','2013-10-27','NSRP'),(581,827,'inositol-1,3,4,5,6-pentakisphosphate kinase activity','F','Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown.','2013-10-27','NSRP'),(582,828,'inositol hexakisphosphate kinase activity','F','Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown.','2013-10-27','NSRP'),(583,829,'inositol heptakisphosphate kinase activity','F','Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown.','2013-10-27','NSRP'),(584,830,'inositol hexakisphosphate 4-kinase activity','F','Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate.','2013-10-27','NSRP'),(585,831,'inositol hexakisphosphate 6-kinase activity','F','Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate.','2013-10-27','NSRP'),(586,832,'inositol hexakisphosphate 5-kinase activity','F','Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.','2013-10-27','NSRP'),(587,833,'inositol heptakisphosphate 4-kinase activity','F','Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate.','2013-10-27','NSRP'),(588,834,'inositol heptakisphosphate 6-kinase activity','F','Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.','2013-10-27','NSRP'),(589,835,'ER ubiquitin ligase complex','C','A ubiquitin ligase complex found in the ER.','2013-10-27','NSRP'),(590,836,'Hrd1p ubiquitin ligase complex','C','A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.','2013-10-27','NSRP'),(591,837,'Doa10p ubiquitin ligase complex','C','A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p.','2013-10-27','NSRP'),(592,838,'Hrd1p ubiquitin ligase ERAD-M complex','C','A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.','2013-10-27','NSRP'),(593,839,'Hrd1p ubiquitin ligase ERAD-L complex','C','A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p.','2013-10-27','NSRP'),(594,900,'translation repressor activity, nucleic acid binding','F','Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.','2013-10-27','NSRP'),(595,901,'translation repressor activity, non-nucleic acid binding','F','Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid.','2013-10-27','NSRP'),(596,902,'cell morphogenesis','P','The developmental process in which the size or shape of a cell is generated and organized.','2013-10-27','NSRP'),(597,903,'regulation of cell shape during vegetative growth phase','P','Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods.','2013-10-27','NSRP'),(598,904,'cell morphogenesis involved in differentiation','P','The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism\'s life history.','2013-10-27','NSRP'),(599,905,'sporocarp development involved in asexual reproduction','P','The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction.','2013-10-27','NSRP'),(600,906,'6,7-dimethyl-8-ribityllumazine synthase activity','F','Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.','2013-10-27','NSRP'),(601,907,'sulfonate dioxygenase activity','F','Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2.','2013-10-27','NSRP'),(602,908,'taurine dioxygenase activity','F','Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite.','2013-10-27','NSRP'),(603,909,'sporocarp development involved in sexual reproduction','P','The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi.','2013-10-27','NSRP'),(604,910,'cytokinesis','P','The division of the cytoplasm and the plasma membrane of a cell and its separation into two daughter cells.','2013-10-27','NSRP'),(605,911,'cytokinesis by cell plate formation','P','The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(606,912,'assembly of actomyosin apparatus involved in cytokinesis','P','The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis.','2013-10-27','NSRP'),(607,913,'preprophase band assembly','P','The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation.','2013-10-27','NSRP'),(608,914,'phragmoplast assembly','P','The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles).','2013-10-27','NSRP'),(609,915,'cytokinesis, actomyosin contractile ring assembly','P','The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.','2013-10-27','NSRP'),(610,916,'actomyosin contractile ring contraction','P','The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle.','2013-10-27','NSRP'),(611,917,'barrier septum assembly','P','The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material.','2013-10-27','NSRP'),(612,918,'barrier septum site selection','P','The process of marking the site where a barrier septum will form.','2013-10-27','NSRP'),(613,919,'cell plate assembly','P','The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast.','2013-10-27','NSRP'),(614,920,'cytokinetic cell separation','P','The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components.','2013-10-27','NSRP'),(615,921,'septin ring assembly','P','The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex.','2013-10-27','NSRP'),(616,922,'spindle pole','C','Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.','2013-10-27','NSRP'),(617,923,'equatorial microtubule organizing center','C','A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.','2013-10-27','NSRP'),(618,924,'gamma-tubulin ring complex, centrosomal','C','A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring.','2013-10-27','NSRP'),(619,927,'gamma-tubulin small complex, centrosomal','C','A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus.','2013-10-27','NSRP'),(620,928,'gamma-tubulin small complex, spindle pole body','C','A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(621,930,'gamma-tubulin complex','C','A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species.','2013-10-27','NSRP'),(622,931,'gamma-tubulin large complex','C','A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe.','2013-10-27','NSRP'),(623,932,'cytoplasmic mRNA processing body','C','A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci.','2013-10-27','NSRP'),(624,933,'adventitious septum','C','A cell septum whose formation is independent of nuclear division.','2013-10-27','NSRP'),(625,934,'porous cell septum','C','A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments.','2013-10-27','NSRP'),(626,935,'barrier septum','C','A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments.','2013-10-27','NSRP'),(627,936,'primary cell septum','C','A cell septum that forms following nuclear division.','2013-10-27','NSRP'),(628,937,'dolipore septum','C','A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome).','2013-10-27','NSRP'),(629,938,'GARP complex','C','A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles.','2013-10-27','NSRP'),(630,939,'condensed chromosome inner kinetochore','C','The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.','2013-10-27','NSRP'),(631,940,'condensed chromosome outer kinetochore','C','The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.','2013-10-27','NSRP'),(632,941,'condensed nuclear chromosome inner kinetochore','C','The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome.','2013-10-27','NSRP'),(633,942,'condensed nuclear chromosome outer kinetochore','C','The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.','2013-10-27','NSRP'),(634,943,'retrotransposon nucleocapsid','C','A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog.','2013-10-27','NSRP'),(635,944,'base pairing with rRNA','F','Interacting selectively and non-covalently with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule.','2013-10-27','NSRP'),(636,945,'base pairing with snRNA','F','Interacting selectively and non-covalently with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule.','2013-10-27','NSRP'),(637,946,'base pairing with tRNA','F','Interacting selectively and non-covalently with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule.','2013-10-27','NSRP'),(638,947,'amino acid catabolic process to alcohol via Ehrlich pathway','P','The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.','2013-10-27','NSRP'),(639,948,'amino acid catabolic process to carboxylic acid via Ehrlich pathway','P','The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.','2013-10-27','NSRP'),(640,949,'aromatic amino acid family catabolic process to alcohol via Ehrlich pathway','P','The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.','2013-10-27','NSRP'),(641,950,'branched-chain amino acid catabolic process to alcohol via Ehrlich pathway','P','The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.','2013-10-27','NSRP'),(642,951,'methionine catabolic process to 3-methylthiopropanol','P','The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols.','2013-10-27','NSRP'),(643,952,'aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway','P','The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.','2013-10-27','NSRP'),(644,953,'branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway','P','The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.','2013-10-27','NSRP'),(645,954,'methionine catabolic process to 3-methylthiopropanoate','P','The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids.','2013-10-27','NSRP'),(646,955,'amino acid catabolic process via Ehrlich pathway','P','The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols.','2013-10-27','NSRP'),(647,956,'nuclear-transcribed mRNA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.','2013-10-27','NSRP'),(648,957,'mitochondrial RNA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.','2013-10-27','NSRP'),(649,958,'mitochondrial mRNA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion.','2013-10-27','NSRP'),(650,959,'mitochondrial RNA metabolic process','P','The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.','2013-10-27','NSRP'),(651,960,'regulation of mitochondrial RNA catabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.','2013-10-27','NSRP'),(652,961,'negative regulation of mitochondrial RNA catabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.','2013-10-27','NSRP'),(653,962,'positive regulation of mitochondrial RNA catabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome.','2013-10-27','NSRP'),(654,963,'mitochondrial RNA processing','P','The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion.','2013-10-27','NSRP'),(655,964,'mitochondrial RNA 5\'-end processing','P','Any process involved in forming the mature 5\' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.','2013-10-27','NSRP'),(656,965,'mitochondrial RNA 3\'-end processing','P','Any process involved in forming the mature 3\' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.','2013-10-27','NSRP'),(657,966,'RNA 5\'-end processing','P','Any process involved in forming the mature 5\' end of an RNA molecule.','2013-10-27','NSRP'),(658,967,'rRNA 5\'-end processing','P','Any process involved in forming the mature 5\' end of an rRNA molecule.','2013-10-27','NSRP'),(659,968,'tRNA exon ligation','P','An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed.','2013-10-27','NSRP'),(660,969,'tRNA exon ligation utilizing ATP as source of linkage phosphate','P','A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5\' and 3\' exons of a tRNA is observed in vertebrate species.','2013-10-27','NSRP'),(661,970,'tRNA exon ligation utilizing GTP as source of linkage phosphate','P','A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5\' and 3\' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2\'-phosphate at the splice junction which is subsequently removed as part of the ligation process.','2013-10-27','NSRP'),(662,971,'tRNA exon ligation utilizing 2\',3\' cyclic phosphate of 5\'-exon as source of linkage phosphate','P','A tRNA exon ligation process in which the splice junction phosphate is derived from the 2\',3\' cyclic phosphate at the 3\'-end of the 5\'-exon. This type of ligation to rejoin the 5\' and 3\' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans.','2013-10-27','NSRP'),(663,972,'transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery','P','The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3\'-UTR of the transcript.','2013-10-27','NSRP'),(664,973,'posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery','P','The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed.','2013-10-27','NSRP'),(665,974,'Prp19 complex','C','A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.','2013-10-27','NSRP'),(666,975,'regulatory region DNA binding','F','Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair.','2013-10-27','NSRP'),(667,976,'transcription regulatory region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.','2013-10-27','NSRP'),(668,977,'RNA polymerase II regulatory region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.','2013-10-27','NSRP'),(669,978,'RNA polymerase II core promoter proximal region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II.','2013-10-27','NSRP'),(670,979,'RNA polymerase II core promoter sequence-specific DNA binding','F','Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase II basal transcription machinery.','2013-10-27','NSRP'),(671,980,'RNA polymerase II distal enhancer sequence-specific DNA binding','F','Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.','2013-10-27','NSRP'),(672,981,'sequence-specific DNA binding RNA polymerase II transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(673,982,'RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.','2013-10-27','NSRP'),(674,983,'RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to modulate transcription by Pol II. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(675,984,'bacterial-type RNA polymerase regulatory region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase.','2013-10-27','NSRP'),(676,985,'bacterial-type RNA polymerase core promoter sequence-specific DNA binding','F','Interacting selectively and non-covalently with a specific DNA sequence in a bacterial-type RNA polymerase core promoter, the region composed of the transcription start site and binding sites for transcription factors of the basal transcription machinery, in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(677,986,'bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase.','2013-10-27','NSRP'),(678,987,'core promoter proximal region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon.','2013-10-27','NSRP'),(679,988,'protein binding transcription factor activity','F','Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(680,989,'transcription factor binding transcription factor activity','F','Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(681,990,'core RNA polymerase binding transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(682,991,'core RNA polymerase II binding transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(683,992,'polymerase III regulatory region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes.','2013-10-27','NSRP'),(684,993,'RNA polymerase II core binding','F','Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.','2013-10-27','NSRP'),(685,994,'RNA polymerase III core binding','F','Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.','2013-10-27','NSRP'),(686,995,'core RNA polymerase III binding transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(687,996,'core DNA-dependent RNA polymerase binding promoter specificity activity','F','Interacting selectively and non-covalently with a DNA-dependent core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of promoter DNA sequence motifs.','2013-10-27','NSRP'),(688,997,'mitochondrial RNA polymerase core promoter sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is part of the core promoter for the mitochondrial RNA polymerase.','2013-10-27','NSRP'),(689,999,'RNA polymerase III type 1 promoter transcriptional preinitiation complex assembly','P','The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 1 promoters require TFIIIA for promoter recognition, which then recruits TFIIIC. TFIIIC in turn recruits TFIIIB, which recruits Pol III to the promoter.','2013-10-27','NSRP'),(690,1000,'bacterial-type RNA polymerase core enzyme binding','F','Interacting selectively and non-covalently with the bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit.','2013-10-27','NSRP'),(691,1001,'mitochondrial single-subunit type RNA polymerase binding','F','Interacting selectively and non-covalently with a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.','2013-10-27','NSRP'),(692,1002,'RNA polymerase III type 1 promoter sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.','2013-10-27','NSRP'),(693,1003,'RNA polymerase III type 2 promoter sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.','2013-10-27','NSRP'),(694,1004,'RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity','F','The function of binding to a specific DNA sequence motif in an RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter.','2013-10-27','NSRP'),(695,1005,'RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity','F','The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC.','2013-10-27','NSRP'),(696,1006,'RNA polymerase III type 3 promoter sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.','2013-10-27','NSRP'),(697,1007,'RNA polymerase III transcription factor binding transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(698,1008,'RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence motif in a type 2 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 2 Pol III promoters, this requires TFIIIC activity.','2013-10-27','NSRP'),(699,1009,'transcription from RNA polymerase III type 2 promoter','P','The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 2 RNAP III promoter. Type 2 RNAP III promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.','2013-10-27','NSRP'),(700,1010,'sequence-specific DNA binding transcription factor recruiting transcription factor activity','F','The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions.','2013-10-27','NSRP'),(701,1011,'sequence-specific DNA binding RNA polymerase recruiting transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC).','2013-10-27','NSRP'),(702,1012,'RNA polymerase II regulatory region DNA binding','F','Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.','2013-10-27','NSRP'),(703,1013,'RNA polymerase I regulatory region DNA binding','F','Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.','2013-10-27','NSRP'),(704,1014,'snoRNA transcription from a type 2 RNA polymerase III promoter','P','The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter.','2013-10-27','NSRP'),(705,1015,'snoRNA transcription from an RNA polymerase II promoter','P','The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.','2013-10-27','NSRP'),(706,1016,'RNA polymerase III regulatory region DNA binding','F','Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.','2013-10-27','NSRP'),(707,1017,'bacterial-type RNA polymerase regulatory region DNA binding','F','Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.','2013-10-27','NSRP'),(708,1018,'mitochondrial RNA polymerase regulatory region DNA binding','F','Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by mitochondrial RNA polymerase. Binding may occur as a high affinity and sequence specific interaction or as a lower affinity interaction observed once a factor has been recruited to the DNA by other factors.','2013-10-27','NSRP'),(709,1019,'plastid RNA polymerase regulatory region DNA binding','F','Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.','2013-10-27','NSRP'),(710,1020,'RNA polymerase III type 3 promoter transcriptional preinitiation complex assembly','P','The aggregation, arrangement and bonding together of proteins on a type 1 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription.','2013-10-27','NSRP'),(711,1021,'RNA polymerase III type 2 promoter transcriptional preinitiation complex assembly','P','The aggregation, arrangement and bonding together of proteins on a type 2 RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Type 2 promoters require TFIIIC for promoter recognition, which then recruits TFIIIB, which in turn which recruits Pol III to the promoter.','2013-10-27','NSRP'),(712,1022,'transcription initiation from RNA polymerase III type 1 promoter','P','A transcription initiation process on a type 1 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.','2013-10-27','NSRP'),(713,1023,'transcription initiation from RNA polymerase III type 2 promoter','P','A transcription initiation process on a type 2 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.','2013-10-27','NSRP'),(714,1024,'transcription initiation from RNA polymerase III type 3 promoter','P','A transcription initiation process on a type 3 RNA polymerase III (Pol III) that results in RNA synthesis by Pol III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.','2013-10-27','NSRP'),(715,1025,'RNA polymerase III transcription factor binding','F','Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III.','2013-10-27','NSRP'),(716,1026,'TFIIIB-type transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.','2013-10-27','NSRP'),(717,1027,'RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.','2013-10-27','NSRP'),(718,1028,'RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.','2013-10-27','NSRP'),(719,1029,'RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.','2013-10-27','NSRP'),(720,1030,'RNA polymerase III type 1 promoter DNA binding','F','Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.','2013-10-27','NSRP'),(721,1031,'RNA polymerase III type 2 promoter DNA binding','F','Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.','2013-10-27','NSRP'),(722,1032,'RNA polymerase III type 3 promoter DNA binding','F','Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.','2013-10-27','NSRP'),(723,1033,'RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity','F','The function of binding to a specific DNA sequence motif in a type 3 RNA polymerase III (Pol III) promoter in order to recruit TFIIIB to the promoter. For type 3 Pol III promoters, this requires SNAPc activity.','2013-10-27','NSRP'),(724,1034,'sequence-specific DNA binding RNA polymerase III transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase III. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(725,1035,'transcription from RNA polymerase III type 3 promoter','P','The synthesis of RNA from a DNA template by RNA polymerase III (RNAP III), originating at a type 3 RNAP III promoter. A type 3 RNAP III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.','2013-10-27','NSRP'),(726,1036,'transcription initiation from RNA polymerase III hybrid type promoter','P','A transcription initiation process on a hybrid type RNA polymerase III (Pol III) that results in RNA synthesis by Pol III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.','2013-10-27','NSRP'),(727,1037,'RNA polymerase III hybrid type promoter DNA binding','F','Interacting selectively and non-covalently with a region of DNA that is a part of a hybrid promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.','2013-10-27','NSRP'),(728,1038,'RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity','F','Once recruited to an RNA polymerase III hybrid type promoter by sequence-specific DNA binding transcription factors, direct DNA binding, or a combination of both, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.','2013-10-27','NSRP'),(729,1039,'RNA polymerase III hybrid type promoter sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.','2013-10-27','NSRP'),(730,1040,'RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex.','2013-10-27','NSRP'),(731,1041,'transcription from a RNA polymerase III hybrid type promoter','P','The synthesis of RNA from a DNA template by RNA polymerase III, originating at a hybrid type RNA polymerase III (RNAP III) promoter. A hybrid RNAP III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene.','2013-10-27','NSRP'),(732,1042,'RNA polymerase I core binding','F','Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits.','2013-10-27','NSRP'),(733,1043,'RNA polymerase III hybrid type promoter transcriptional preinitiation complex assembly','P','The aggregation, arrangement and bonding together of proteins on a hybrid type RNA polymerase III (Pol III) promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is the first step of transcription. Hybrid type promoters contain both gene-internal and upstream elements. An example of a hybrid promoter is the U6 snRNA gene.','2013-10-27','NSRP'),(734,1044,'mitochondrial RNA polymerase regulatory region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a specific sequence of DNA that controls the transcription of a region of DNA by mitochondrial RNA polymerase.','2013-10-27','NSRP'),(735,1045,'mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase.','2013-10-27','NSRP'),(736,1046,'core promoter sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.','2013-10-27','NSRP'),(737,1047,'core promoter binding','F','Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.','2013-10-27','NSRP'),(738,1048,'RNA polymerase IV core binding','F','Interacting selectively and non-covalently with RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production.','2013-10-27','NSRP'),(739,1049,'RNA polymerase V core binding','F','Interacting selectively and non-covalently with RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing.','2013-10-27','NSRP'),(740,1050,'single-subunit type RNA polymerase binding','F','Interacting selectively and non-covalently with a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.','2013-10-27','NSRP'),(741,1051,'plastid single-subunit type RNA polymerase binding','F','Interacting selectively and non-covalently with a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.','2013-10-27','NSRP'),(742,1052,'plastid PEP RNA polymerase core enzyme binding','F','Interacting selectively and non-covalently with the bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit.','2013-10-27','NSRP'),(743,1053,'plastid sigma factor activity','F','Interacting selectively and non-covalently with a plastid PEP core RNA polymerase to form a holoenzyme complex and also, while present in the holoenzyme, interacting with promoter sequences in order to confer sequence specific recognition of plastid PEP core promoter DNA sequence motifs.','2013-10-27','NSRP'),(744,1054,'RNA polymerase I activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(745,1055,'RNA polymerase II activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(746,1056,'RNA polymerase III activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(747,1057,'RNA polymerase IV activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(748,1058,'RNA polymerase V activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(749,1059,'transcription from RNA polymerase IV promoter','P','The synthesis of RNA from a DNA template by RNA polymerase IV (Pol III), originating at a Pol IV-specific promoter.','2013-10-27','NSRP'),(750,1060,'transcription from RNA polymerase V promoter','P','The synthesis of RNA from a DNA template by RNA polymerase V (Pol III), originating at a Pol V-specific promoter.','2013-10-27','NSRP'),(751,1061,'bacterial-type RNA polymerase activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(752,1062,'plastid PEP-A RNA polymerase activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(753,1063,'plastid PEP-B RNA polymerase activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(754,1064,'single subunit type RNA polymerase activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(755,1065,'mitochondrial single subunit type RNA polymerase activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type mitochondrial RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(756,1066,'plastid single subunit type RNA polymerase activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(757,1067,'regulatory region nucleic acid binding','F','Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.','2013-10-27','NSRP'),(758,1068,'transcription regulatory region RNA binding','F','Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon.','2013-10-27','NSRP'),(759,1069,'regulatory region RNA binding','F','Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.','2013-10-27','NSRP'),(760,1070,'RNA binding transcription factor activity','F','Interacting selectively and non-covalently with an RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(761,1071,'nucleic acid binding transcription factor activity','F','Interacting selectively and non-covalently with a DNA or RNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(762,1072,'RNA binding transcription antitermination factor activity','F','Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein.','2013-10-27','NSRP'),(763,1073,'DNA binding transcription antitermination factor activity','F','Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein.','2013-10-27','NSRP'),(764,1074,'RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(765,1075,'RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly','F','Interacting selectively and non-covalently with a specific DNA sequence in an RNA polymerase II (Pol II) core promoter, the region composed of the transcription start site and binding sites for transcription factors of the Pol II basal transcription machinery, in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(766,1076,'RNA polymerase II transcription factor binding transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(767,1077,'RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.','2013-10-27','NSRP'),(768,1078,'RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(769,1079,'nitrogen catabolite regulation of transcription from RNA polymerase II promoter','P','A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.','2013-10-27','NSRP'),(770,1080,'nitrogen catabolite activation of transcription from RNA polymerase II promoter','P','A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.','2013-10-27','NSRP'),(771,1081,'nitrogen catabolite repression of transcription from RNA polymerase II promoter','P','A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.','2013-10-27','NSRP'),(772,1082,'RNA polymerase I transcription factor binding transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(773,1083,'RNA polymerase II basal transcription factor binding transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(774,1084,'TFIID-class binding transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.','2013-10-27','NSRP'),(775,1085,'RNA polymerase II transcription factor binding','F','Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.','2013-10-27','NSRP'),(776,1086,'TFIIA-class binding transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.','2013-10-27','NSRP'),(777,1087,'TFIIB-class binding transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.','2013-10-27','NSRP'),(778,1088,'TFIIE-class binding transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.','2013-10-27','NSRP'),(779,1089,'TFIIF-class binding transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.','2013-10-27','NSRP'),(780,1090,'TFIIH-class binding transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.','2013-10-27','NSRP'),(781,1091,'RNA polymerase II basal transcription factor binding','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.','2013-10-27','NSRP'),(782,1092,'TFIIA-class transcription factor binding','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.','2013-10-27','NSRP'),(783,1093,'TFIIB-class transcription factor binding','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.','2013-10-27','NSRP'),(784,1094,'TFIID-class transcription factor binding','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.','2013-10-27','NSRP'),(785,1095,'TFIIE-class transcription factor binding','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.','2013-10-27','NSRP'),(786,1096,'TFIIF-class transcription factor binding','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.','2013-10-27','NSRP'),(787,1097,'TFIIH-class transcription factor binding','F','Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.','2013-10-27','NSRP'),(788,1098,'basal transcription machinery binding','F','Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.','2013-10-27','NSRP'),(789,1099,'basal RNA polymerase II transcription machinery binding','F','Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.','2013-10-27','NSRP'),(790,1100,'negative regulation of exit from mitosis','P','Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).','2013-10-27','NSRP'),(791,1101,'response to acid','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus.','2013-10-27','NSRP'),(792,1102,'RNA polymerase II activating transcription factor binding','F','Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription.','2013-10-27','NSRP'),(793,1103,'RNA polymerase II repressing transcription factor binding','F','Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription.','2013-10-27','NSRP'),(794,1104,'RNA polymerase II transcription cofactor activity','F','Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal RNAP II transcription machinery.','2013-10-27','NSRP'),(795,1105,'RNA polymerase II transcription coactivator activity','F','Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.','2013-10-27','NSRP'),(796,1106,'RNA polymerase II transcription corepressor activity','F','Interacting selectively and non-covalently with an RNA polymerase II repressing transcription factor and also with the RNA polymerase II basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.','2013-10-27','NSRP'),(797,1108,'bacterial-type RNA polymerase holo enzyme binding','F','Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase.','2013-10-27','NSRP'),(798,1109,'promoter clearance during DNA-dependent transcription','P','Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.','2013-10-27','NSRP'),(799,1110,'promoter clearance from RNA polymerase III promoter','P','Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase.','2013-10-27','NSRP'),(800,1111,'promoter clearance from RNA polymerase II promoter','P','Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.','2013-10-27','NSRP'),(801,1112,'DNA-dependent transcriptional open complex formation','P','Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.','2013-10-27','NSRP'),(802,1113,'transcriptional open complex formation at RNA polymerase II promoter','P','Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.','2013-10-27','NSRP'),(803,1114,'protein-DNA-RNA complex','C','A macromolecular complex containing protein, DNA, and RNA molecules.','2013-10-27','NSRP'),(804,1115,'protein-DNA-RNA complex subunit organization','P','Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex.','2013-10-27','NSRP'),(805,1116,'protein-DNA-RNA complex assembly','P','The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex.','2013-10-27','NSRP'),(806,1117,'protein-DNA-RNA complex disassembly','P','The disaggregation of a protein-DNA-RNA complex into its constituent components.','2013-10-27','NSRP'),(807,1118,'transcription ternary complex disassembly','P','The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components.','2013-10-27','NSRP'),(808,1119,'protein-DNA-RNA complex remodeling','P','The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex.','2013-10-27','NSRP'),(809,1120,'protein-DNA complex remodeling','P','The acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex.','2013-10-27','NSRP'),(810,1121,'transcription from bacterial-type RNA polymerase promoter','P','The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter.','2013-10-27','NSRP'),(811,1122,'promoter clearance from bacterial-type RNA polymerase promoter','P','Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor.','2013-10-27','NSRP'),(812,1123,'transcription initiation from bacterial-type RNA polymerase promoter','P','Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription.','2013-10-27','NSRP'),(813,1124,'transcription elongation from bacterial-type RNA polymerase promoter','P','The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase.','2013-10-27','NSRP'),(814,1125,'transcription termination from bacterial-type RNA polymerase promoter','P','The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed.','2013-10-27','NSRP'),(815,1126,'bacterial-type RNA polymerase preinitiation complex assembly','P','The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.','2013-10-27','NSRP'),(816,1127,'transcriptional open complex formation at bacterial-type RNA polymerase promoter','P','Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.','2013-10-27','NSRP'),(817,1128,'RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly','F','Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery.','2013-10-27','NSRP'),(818,1129,'TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly','F','Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.','2013-10-27','NSRP'),(819,1130,'sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(820,1131,'bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(821,1132,'TBP-class protein binding RNA polymerase II transcription factor activity','F','Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.','2013-10-27','NSRP'),(822,1133,'sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity','F','Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA by RNA polymerase II and recruiting another transcription factor to the DNA in order to modulate transcription by RNAP II.','2013-10-27','NSRP'),(823,1134,'transcription factor recruiting transcription factor activity','F','Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, and with another protein, macromolecule, or complex, recruiting that specific transcription factor to the transcription machinery complex and thus permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(824,1135,'RNA polymerase II transcription factor recruiting transcription factor activity','F','The function of binding to an RNA polymerase II (RNAP II) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP II.','2013-10-27','NSRP'),(825,1136,'TFIIE-class transcription factor recruiting transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIE-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II.','2013-10-27','NSRP'),(826,1137,'TFIIF-class transcription factor recruiting transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIF-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II.','2013-10-27','NSRP'),(827,1138,'TFIIH-class transcription factor recruiting transcription factor activity','F','Interacting selectively and non-covalently with a basal RNA polymerase II (RNAP II) transcription factor of the TFIIH-class in order to recruit it to the RNAP II preinitiation complex (PIC) in order to modulate transcription by RNAP II.','2013-10-27','NSRP'),(828,1139,'core RNA polymerase II recruiting transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase.','2013-10-27','NSRP'),(829,1140,'bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to modulate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(830,1141,'bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a bacterial-type RNA polymerase in order to stop, prevent, or reduce the frequency, rate or extent of transcription from a bacterial-type RNA polymerase promoter.','2013-10-27','NSRP'),(831,1142,'sequence-specific DNA binding mitochondrial RNA polymerase transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(832,1143,'mitochondrial RNA polymerase core promoter sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence that is part of the core promoter for mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(833,1144,'mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for a mitochondrial RNA polymerase in order to modulate transcription by mitochondrial RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(834,1145,'mitochondrial RNA polymerase termination site sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase.','2013-10-27','NSRP'),(835,1146,'mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a sequence of DNA that is a terminator for mitochondrial RNA polymerase in order to promote transcription termination by mitochondrial RNA polymerase.','2013-10-27','NSRP'),(836,1147,'transcription termination site sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.','2013-10-27','NSRP'),(837,1148,'bacterial-type RNA polymerase termination site sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is a terminator for bacterial-type RNA polymerase.','2013-10-27','NSRP'),(838,1149,'bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase.','2013-10-27','NSRP'),(839,1150,'bacterial-type RNA polymerase enhancer sequence-specific DNA binding','F','Interacting selectively and non-covalently with a sequence of DNA that is an enhancer region that helps activate transcription of a gene or operon by a bacterial-type RNA polymerase. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site, although they can be further away or may be downstream of the promoter. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences.','2013-10-27','NSRP'),(840,1151,'bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a sequence of DNA that is a bacterial-type enhancer region in order to activate transcription by bacterial-type RNA polymerase. The transcription factor may or may not also interact selectively with a protein or macromolecular complex. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences.','2013-10-27','NSRP'),(841,1152,'RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity','F','The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter.','2013-10-27','NSRP'),(842,1153,'RNA polymerase III transcription factor recruiting transcription factor activity','F','The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III.','2013-10-27','NSRP'),(843,1154,'TFIIIB-class transcription factor binding','F','Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.','2013-10-27','NSRP'),(844,1155,'TFIIIA-class transcription factor binding','F','Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at type 1 promoters (5S genes) by RNA polymerase III.','2013-10-27','NSRP'),(845,1156,'TFIIIC-class transcription factor binding','F','Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIC class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.','2013-10-27','NSRP'),(846,1157,'RNA polymerase III type 1 promoter TFIIIB recruiting transcription factor activity','F','The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the Pol III recruiting factor TFIIIB to the promoter. For type 1 Pol III promoters, this requires both TFIIIA and TFIIIC.','2013-10-27','NSRP'),(847,1158,'enhancer sequence-specific DNA binding','F','Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.','2013-10-27','NSRP'),(848,1159,'core promoter proximal region DNA binding','F','Interacting selectively and non-covalently with a region of DNA that is in cis with and relatively close to the core promoter. The transcribed region might be described as a gene, cistron, or operon.','2013-10-27','NSRP'),(849,1160,'transcription termination site DNA binding','F','Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon.','2013-10-27','NSRP'),(850,1161,'intronic transcription regulatory region sequence-specific DNA binding','F','Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within.','2013-10-27','NSRP'),(851,1162,'RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding','F','Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within.','2013-10-27','NSRP'),(852,1163,'RNA polymerase I regulatory region sequence-specific DNA binding','F','Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I.','2013-10-27','NSRP'),(853,1164,'RNA polymerase I CORE element sequence-specific DNA binding','F','Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE.','2013-10-27','NSRP'),(854,1165,'RNA polymerase I upstream control element sequence-specific DNA binding','F','Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I.','2013-10-27','NSRP'),(855,1166,'RNA polymerase I enhancer sequence-specific DNA binding','F','Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.','2013-10-27','NSRP'),(856,1167,'sequence-specific DNA binding RNA polymerase I transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(857,1168,'RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I.','2013-10-27','NSRP'),(858,1169,'RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I.','2013-10-27','NSRP'),(859,1170,'RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I.','2013-10-27','NSRP'),(860,1171,'reverse transcription','P','A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis.','2013-10-27','NSRP'),(861,1172,'transcription, RNA-dependent','P','The cellular synthesis of RNA on a template of RNA.','2013-10-27','NSRP'),(862,1173,'DNA-dependent transcriptional start site selection','P','Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.','2013-10-27','NSRP'),(863,1174,'transcriptional start site selection at RNA polymerase II promoter','P','Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.','2013-10-27','NSRP'),(864,1175,'transcriptional start site selection at RNA polymerase III promoter','P','Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.','2013-10-27','NSRP'),(865,1176,'transcriptional start site selection at bacterial-type RNA polymerase promoter','P','Any process involved in the selection of the specific location within the template strand of a bacterial-type RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.','2013-10-27','NSRP'),(866,1177,'regulation of transcriptional open complex formation at RNA polymerase II promoter','P','Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.','2013-10-27','NSRP'),(867,1178,'regulation of transcriptional start site selection at RNA polymerase II promoter','P','Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.','2013-10-27','NSRP'),(868,1179,'RNA polymerase I transcription factor binding','F','Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I.','2013-10-27','NSRP'),(869,1180,'transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript','P','Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript, resulting in the subsequent synthesis of rRNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.','2013-10-27','NSRP'),(870,1181,'core RNA polymerase I binding transcription factor activity','F','Interacting selectively and non-covalently with an RNA polymerase I (RNAP I) complex, typically composed of fourteen subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(871,1182,'promoter clearance from RNA polymerase I promoter','P','Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.','2013-10-27','NSRP'),(872,1183,'transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript','P','The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I.','2013-10-27','NSRP'),(873,1184,'promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript','P','Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.','2013-10-27','NSRP'),(874,1185,'termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript','P','The process in which the synthesis of an rRNA molecule from a promoter for the nuclear large ribosomal RNA (rRNA) transcript by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit.','2013-10-27','NSRP'),(875,1186,'RNA polymerase I transcription factor recruiting transcription factor activity','F','The function of binding to an RNA polymerase I (RNAP I) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP I.','2013-10-27','NSRP'),(876,1187,'RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity','F','Interacting selectively and non-covalently with the CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery and also binding to an RNA polymerase I (RNAP I) transcription factor to recruit it to the transcription machinery complex in order to modulate transcription by RNA polymerase I.','2013-10-27','NSRP'),(877,1188,'RNA polymerase I transcriptional preinitiation complex assembly','P','The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter.','2013-10-27','NSRP'),(878,1189,'RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript','P','The aggregation, arrangement and bonding together of proteins on CORE promoter element DNA of the nuclear large ribosomal RNA (rRNA) transcript to form a transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from the large rRNA promoter, resulting in the subsequent synthesis of the large rRNA transcript.','2013-10-27','NSRP'),(879,1190,'RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription','F','Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(880,1191,'RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription','F','Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.','2013-10-27','NSRP'),(881,1300,'chronological cell aging','P','The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.','2013-10-27','NSRP'),(882,1301,'progressive alteration of chromatin involved in cell aging','P','The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype.','2013-10-27','NSRP'),(883,1302,'replicative cell aging','P','The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division.','2013-10-27','NSRP'),(884,1303,'nucleolar fragmentation involved in replicative aging','P','A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells.','2013-10-27','NSRP'),(885,1304,'progressive alteration of chromatin involved in replicative cell aging','P','A process that results in changes in chromatin structure contributing to replicative cell aging.','2013-10-27','NSRP'),(886,1305,'progressive alteration of chromatin involved in chronological cell aging','P','A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells.','2013-10-27','NSRP'),(887,1306,'age-dependent response to oxidative stress','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism.','2013-10-27','NSRP'),(888,1307,'extrachromosomal circular DNA accumulation involved in replicative cell aging','P','Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.','2013-10-27','NSRP'),(889,1308,'negative regulation of chromatin silencing involved in replicative cell aging','P','The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins.','2013-10-27','NSRP'),(890,1309,'age-dependent telomere shortening','P','Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process.','2013-10-27','NSRP'),(891,1310,'extrachromosomal rDNA circle accumulation involved in replicative cell aging','P','Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication.','2013-10-27','NSRP'),(892,1311,'formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging','P','Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age.','2013-10-27','NSRP'),(893,1312,'replication of extrachromosomal rDNA circles involved in replicative cell aging','P','Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication.','2013-10-27','NSRP'),(894,1313,'formation of extrachromosomal circular DNA involved in replicative cell aging','P','Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age.','2013-10-27','NSRP'),(895,1314,'replication of extrachromosomal circular DNA involved in replicative cell aging','P','Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication.','2013-10-27','NSRP'),(896,1315,'age-dependent response to reactive oxygen species','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.','2013-10-27','NSRP'),(897,1316,'age-dependent response to reactive oxygen species involved in replicative cell aging','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.','2013-10-27','NSRP'),(898,1317,'accumulation of oxidatively modified proteins involved in replicative cell aging','P','Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking.','2013-10-27','NSRP'),(899,1318,'formation of oxidatively modified proteins involved in replicative cell aging','P','Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking.','2013-10-27','NSRP'),(900,1319,'inheritance of oxidatively modified proteins involved in replicative cell aging','P','A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells.','2013-10-27','NSRP'),(901,1320,'age-dependent response to reactive oxygen species involved in chronological cell aging','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism.','2013-10-27','NSRP'),(902,1321,'age-dependent general metabolic decline involved in replicative cell aging','P','A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function.','2013-10-27','NSRP'),(903,1322,'age-dependent response to oxidative stress involved in replicative cell aging','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.','2013-10-27','NSRP'),(904,1323,'age-dependent general metabolic decline involved in chronological cell aging','P','A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function.','2013-10-27','NSRP'),(905,1324,'age-dependent response to oxidative stress involved in chronological cell aging','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism.','2013-10-27','NSRP'),(906,1325,'formation of extrachromosomal circular DNA','P','Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats.','2013-10-27','NSRP'),(907,1326,'replication of extrachromosomal circular DNA','P','Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication.','2013-10-27','NSRP'),(908,1400,'mating projection base','C','The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone.','2013-10-27','NSRP'),(909,1401,'mitochondrial sorting and assembly machinery complex','C','A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex.','2013-10-27','NSRP'),(910,1402,'signal transduction involved in filamentous growth','P','Relaying of environmental signals promoting filamentous growth.','2013-10-27','NSRP'),(911,1403,'invasive growth in response to glucose limitation','P','A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(912,1404,'invasive growth','P','OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue.','2013-10-27','NSRP'),(913,1405,'presequence translocase-associated import motor','C','Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix.','2013-10-27','NSRP'),(914,1406,'glycerophosphodiester transmembrane transporter activity','F','Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.','2013-10-27','NSRP'),(915,1407,'glycerophosphodiester transport','P','The directed movement of glycerophosphodiesters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol.','2013-10-27','NSRP'),(916,1408,'guanine nucleotide transport','P','The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(917,1409,'guanine nucleotide transmembrane transporter activity','F','Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other.','2013-10-27','NSRP'),(918,1410,'chlamydospore formation','P','The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans.','2013-10-27','NSRP'),(919,1411,'hyphal tip','C','The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.','2013-10-27','NSRP'),(920,1501,'skeletal system development','P','The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).','2013-10-27','NSRP'),(921,1502,'cartilage condensation','P','The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes.','2013-10-27','NSRP'),(922,1503,'ossification','P','The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.','2013-10-27','NSRP'),(923,1504,'neurotransmitter uptake','P','The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft.','2013-10-27','NSRP'),(924,1505,'regulation of neurotransmitter levels','P','Any process that modulates levels of neurotransmitter.','2013-10-27','NSRP'),(925,1506,'neurotransmitter biosynthetic process and storage','P','OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules.','2013-10-27','NSRP'),(926,1507,'acetylcholine catabolic process in synaptic cleft','P','The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission.','2013-10-27','NSRP'),(927,1508,'regulation of action potential','P','Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell.','2013-10-27','NSRP'),(928,1509,'legumain activity','F','OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds.','2013-10-27','NSRP'),(929,1510,'RNA methylation','P','Posttranscriptional addition of a methyl group to either a nucleotide or 2\'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.','2013-10-27','NSRP'),(930,1511,'fibrillin','F','OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome.','2013-10-27','NSRP'),(931,1512,'dihydronicotinamide riboside quinone reductase activity','F','Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone.','2013-10-27','NSRP'),(932,1514,'selenocysteine incorporation','P','The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine.','2013-10-27','NSRP'),(933,1515,'opioid peptide activity','F','Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect.','2013-10-27','NSRP'),(934,1516,'prostaglandin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.','2013-10-27','NSRP'),(935,1517,'N-acetylglucosamine 6-O-sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3\',5\'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate.','2013-10-27','NSRP'),(936,1518,'voltage-gated sodium channel complex','C','A sodium channel in a cell membrane whose opening is governed by the membrane potential.','2013-10-27','NSRP'),(937,1519,'peptide amidation','P','The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions.','2013-10-27','NSRP'),(938,1520,'outer dense fiber','C','Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile.','2013-10-27','NSRP'),(939,1522,'pseudouridine synthesis','P','The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs.','2013-10-27','NSRP'),(940,1523,'retinoid metabolic process','P','The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.','2013-10-27','NSRP'),(941,1524,'globin','F','OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins.','2013-10-27','NSRP'),(942,1525,'angiogenesis','P','Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.','2013-10-27','NSRP'),(943,1526,'proteoglycan sulfate transfer','P','OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3\'-phosphoadenyl sulfate.','2013-10-27','NSRP'),(944,1527,'microfibril','C','Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins.','2013-10-27','NSRP'),(945,1528,'elastin','F','OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues.','2013-10-27','NSRP'),(946,1529,'elastin','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(947,1530,'lipopolysaccharide binding','F','Interacting selectively and non-covalently with lipopolysaccharide.','2013-10-27','NSRP'),(948,1531,'interleukin-21 receptor binding','F','Interacting selectively and non-covalently with the interleukin-21 receptor.','2013-10-27','NSRP'),(949,1532,'interleukin-21 receptor activity','F','Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(950,1533,'cornified envelope','C','An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells.','2013-10-27','NSRP'),(951,1534,'radial spoke','C','Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.','2013-10-27','NSRP'),(952,1535,'radial spokehead','C','Protein complex forming part of eukaryotic flagellar apparatus.','2013-10-27','NSRP'),(953,1536,'radial spoke stalk','C','Globular portion of the radial spoke that projects towards the central pair of microtubules.','2013-10-27','NSRP'),(954,1537,'N-acetylgalactosamine 4-O-sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3\',5\'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate.','2013-10-27','NSRP'),(955,1539,'ciliary or bacterial-type flagellar motility','P','Cell motility due to movement of cilia or flagella.','2013-10-27','NSRP'),(956,1540,'beta-amyloid binding','F','Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor.','2013-10-27','NSRP'),(957,1541,'ovarian follicle development','P','The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.','2013-10-27','NSRP'),(958,1542,'ovulation from ovarian follicle','P','The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus.','2013-10-27','NSRP'),(959,1543,'ovarian follicle rupture','P','Disruption of theca cell layer releasing follicular fluid and/or the oocyte.','2013-10-27','NSRP'),(960,1544,'initiation of primordial ovarian follicle growth','P','Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle).','2013-10-27','NSRP'),(961,1545,'primary ovarian follicle growth','P','Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle).','2013-10-27','NSRP'),(962,1546,'preantral ovarian follicle growth','P','Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation.','2013-10-27','NSRP'),(963,1547,'antral ovarian follicle growth','P','Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.','2013-10-27','NSRP'),(964,1548,'follicular fluid formation in ovarian follicle antrum','P','The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis.','2013-10-27','NSRP'),(965,1549,'cumulus cell differentiation','P','The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell.','2013-10-27','NSRP'),(966,1550,'ovarian cumulus expansion','P','Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.','2013-10-27','NSRP'),(967,1551,'ovarian follicle endowment','P','Association of oocytes with supporting epithelial granulosa cells to form primordial follicles.','2013-10-27','NSRP'),(968,1552,'ovarian follicle atresia','P','A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed.','2013-10-27','NSRP'),(969,1553,'luteinization','P','The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.','2013-10-27','NSRP'),(970,1554,'luteolysis','P','The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy.','2013-10-27','NSRP'),(971,1555,'oocyte growth','P','The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.','2013-10-27','NSRP'),(972,1556,'oocyte maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.','2013-10-27','NSRP'),(973,1557,'metabolic process resulting in cell growth','P','OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell.','2013-10-27','NSRP'),(974,1558,'regulation of cell growth','P','Any process that modulates the frequency, rate, extent or direction of cell growth.','2013-10-27','NSRP'),(975,1559,'regulation of cell growth by detection of nuclear:cytoplasmic ratio','P','Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.','2013-10-27','NSRP'),(976,1560,'regulation of cell growth by extracellular stimulus','P','Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.','2013-10-27','NSRP'),(977,1561,'fatty acid alpha-oxidation','P','A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway.','2013-10-27','NSRP'),(978,1562,'response to protozoan','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan.','2013-10-27','NSRP'),(979,1563,'detection of protozoan','P','The series of events in which a stimulus from a protozoan is received and converted into a molecular signal.','2013-10-27','NSRP'),(980,1564,'resistance to pathogenic protozoa','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(981,1565,'phorbol ester receptor activity','F','Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity.','2013-10-27','NSRP'),(982,1566,'non-kinase phorbol ester receptor activity','F','Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity.','2013-10-27','NSRP'),(983,1567,'cholesterol 25-hydroxylase activity','F','Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O.','2013-10-27','NSRP'),(984,1568,'blood vessel development','P','The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.','2013-10-27','NSRP'),(985,1569,'patterning of blood vessels','P','The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.','2013-10-27','NSRP'),(986,1570,'vasculogenesis','P','The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.','2013-10-27','NSRP'),(987,1571,'non-tyrosine kinase fibroblast growth factor receptor activity','F','Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity.','2013-10-27','NSRP'),(988,1572,'lactosylceramide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1\') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides.','2013-10-27','NSRP'),(989,1573,'ganglioside metabolic process','P','The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.','2013-10-27','NSRP'),(990,1574,'ganglioside biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues.','2013-10-27','NSRP'),(991,1575,'globoside metabolic process','P','The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes.','2013-10-27','NSRP'),(992,1576,'globoside biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I).','2013-10-27','NSRP'),(993,1577,'galectin','F','OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars.','2013-10-27','NSRP'),(994,1578,'microtubule bundle formation','P','A process that results in a parallel arrangement of microtubules.','2013-10-27','NSRP'),(995,1579,'medium-chain fatty acid transport','P','The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.','2013-10-27','NSRP'),(996,1580,'detection of chemical stimulus involved in sensory perception of bitter taste','P','The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.','2013-10-27','NSRP'),(997,1581,'detection of chemical stimulus involved in sensory perception of sour taste','P','The series of events required for a sour taste stimulus to be received and converted to a molecular signal.','2013-10-27','NSRP'),(998,1582,'detection of chemical stimulus involved in sensory perception of sweet taste','P','The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.','2013-10-27','NSRP'),(999,1583,'detection of chemical stimulus involved in sensory perception of salty taste','P','The series of events required for a salty taste stimulus to be received and converted to a molecular signal.','2013-10-27','NSRP'),(1000,1584,'rhodopsin-like receptor activity','F','OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor.','2013-10-27','NSRP'),(1001,1586,'Gi/o-coupled serotonin receptor activity','F','Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels.','2013-10-27','NSRP'),(1002,1587,'Gq/11-coupled serotonin receptor activity','F','Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.','2013-10-27','NSRP'),(1003,1588,'dopamine neurotransmitter receptor activity, coupled via Gs','F','Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity.','2013-10-27','NSRP'),(1004,1589,'dopamine D5 receptor activity','F','A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D5 receptors.','2012-03-14','NSRP'),(1005,1590,'dopamine D1 receptor activity','F','A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D1 receptors.','2012-03-14','NSRP'),(1006,1591,'dopamine neurotransmitter receptor activity, coupled via Gi/Go','F','Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity.','2013-10-27','NSRP'),(1007,1592,'dopamine D3 receptor activity','F','A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D3 receptors.','2012-03-14','NSRP'),(1008,1593,'dopamine D4 receptor activity','F','A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D4 receptors.','2012-03-14','NSRP'),(1009,1594,'trace-amine receptor activity','F','Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals.','2013-10-27','NSRP'),(1010,1595,'angiotensin receptor activity','F','Combining with angiotensin to initiate a change in cell activity.','2013-10-27','NSRP'),(1011,1596,'angiotensin type I receptor activity','F','An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms.','2013-10-27','NSRP'),(1012,1597,'apelin-like receptor','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1013,1598,'chemokine receptor-like receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1014,1599,'endothelin-A receptor activity','F','A G-protein coupled receptor that preferentially binds endothelin 1.','2012-03-14','NSRP'),(1015,1600,'endothelin-B receptor activity','F','A G-protein coupled receptor that binds all endothelin molecules with approximately equal affinity.','2012-03-14','NSRP'),(1016,1601,'peptide YY receptor activity','F','Combining with gut peptide YY to initiate a change in cell activity.','2013-10-27','NSRP'),(1017,1602,'pancreatic polypeptide receptor activity','F','Combining with pancreatic polypeptide PP to initiate a change in cell activity.','2013-10-27','NSRP'),(1018,1603,'vasopressin-like receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1019,1604,'urotensin II receptor activity','F','Combining with urotensin II to initiate a change in cell activity.','2013-10-27','NSRP'),(1020,1605,'adrenomedullin receptor activity','F','Combining with adrenomedullin to initiate a change in cell activity.','2013-10-27','NSRP'),(1021,1606,'GPR37/endothelin B-like receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1022,1607,'neuromedin U receptor activity','F','Combining with neuromedin U to initiate a change in cell activity.','2013-10-27','NSRP'),(1023,1608,'G-protein coupled nucleotide receptor activity','F','Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(1024,1609,'G-protein coupled adenosine receptor activity','F','Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(1025,1614,'purinergic nucleotide receptor activity','F','Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1026,1615,'thyrotropin releasing hormone and secretagogue-like receptors activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1027,1616,'growth hormone secretagogue receptor activity','F','Combining with ghrelin to initiate a change in cell activity.','2013-10-27','NSRP'),(1028,1617,'growth hormone secretagogue-like receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1029,1618,'virus receptor activity','F','Combining with a virus component and mediating entry of the virus into the cell.','2013-10-27','NSRP'),(1030,1619,'lysosphingolipid and lysophosphatidic acid receptor activity','F','Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity.','2013-10-27','NSRP'),(1031,1621,'ADP receptor activity','F','Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1032,1626,'nociceptin receptor activity','F','Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.','2013-10-27','NSRP'),(1033,1627,'leucine-rich G-protein receptor-like receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1034,1628,'gastropyloric receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1035,1629,'G-protein receptor 45-like receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1036,1630,'GP40-like receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1037,1631,'cysteinyl leukotriene receptor activity','F','Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine.','2013-10-27','NSRP'),(1038,1632,'leukotriene B4 receptor activity','F','Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate.','2013-10-27','NSRP'),(1039,1633,'secretin-like receptor activity','F','OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor.','2013-10-27','NSRP'),(1040,1634,'pituitary adenylate cyclase-activating polypeptide receptor activity','F','A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide.','2013-10-27','NSRP'),(1041,1635,'calcitonin gene-related polypeptide receptor activity','F','Combining with a calcitonin gene-related polypeptide to initiate a change in cell activity.','2013-10-27','NSRP'),(1042,1636,'corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1043,1637,'G-protein coupled chemoattractant receptor activity','F','Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(1044,1639,'PLC activating G-protein coupled glutamate receptor activity','F','A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system.','2013-10-27','NSRP'),(1045,1640,'adenylate cyclase inhibiting G-protein coupled glutamate receptor activity','F','Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.','2013-10-27','NSRP'),(1046,1641,'group II metabotropic glutamate receptor activity','F','A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.','2013-10-27','NSRP'),(1047,1642,'group III metabotropic glutamate receptor activity','F','A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity.','2013-10-27','NSRP'),(1048,1646,'cAMP receptor activity','F','Combining with cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1049,1647,'G-protein coupled cytokinin receptor activity','F','Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(1050,1648,'proteinase activated receptor activity','F','A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.','2013-10-27','NSRP'),(1051,1649,'osteoblast differentiation','P','The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.','2013-10-27','NSRP'),(1052,1650,'fibrillar center','C','A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.','2013-10-27','NSRP'),(1053,1651,'dense fibrillar component','C','A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins.','2013-10-27','NSRP'),(1054,1652,'granular component','C','A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm.','2013-10-27','NSRP'),(1055,1653,'peptide receptor activity','F','Combining with an extracellular or intracellular peptide to initiate a change in cell activity.','2013-10-27','NSRP'),(1056,1654,'eye development','P','The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.','2013-10-27','NSRP'),(1057,1655,'urogenital system development','P','The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.','2013-10-27','NSRP'),(1058,1656,'metanephros development','P','The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.','2013-10-27','NSRP'),(1059,1657,'ureteric bud development','P','The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.','2013-10-27','NSRP'),(1060,1658,'branching involved in ureteric bud morphogenesis','P','The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.','2013-10-27','NSRP'),(1061,1659,'temperature homeostasis','P','A homeostatic process in which an organism modulates its internal body temperature.','2013-10-27','NSRP'),(1062,1660,'fever generation','P','The heat generation process that results in a rise in body temperature above the normal, often as a response to infection.','2013-10-27','NSRP'),(1063,1661,'conditioned taste aversion','P','A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus.','2013-10-27','NSRP'),(1064,1662,'behavioral fear response','P','An acute behavioral change resulting from a perceived external threat.','2013-10-27','NSRP'),(1065,1664,'G-protein coupled receptor binding','F','Interacting selectively and non-covalently with a G-protein coupled receptor.','2013-10-27','NSRP'),(1066,1665,'alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity','F','Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein.','2013-10-27','NSRP'),(1067,1666,'response to hypoxia','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.','2013-10-27','NSRP'),(1068,1667,'ameboidal cell migration','P','Cell migration that is accomplished by extension and retraction of a pseudopodium.','2013-10-27','NSRP'),(1069,1669,'acrosomal vesicle','C','A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.','2013-10-27','NSRP'),(1070,1670,'dopamine D2 receptor activity','F','A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D2 receptors.','2012-03-14','NSRP'),(1071,1671,'ATPase activator activity','F','Functions to increase the rate of ATP hydrolysis.','2013-10-27','NSRP'),(1072,1672,'regulation of chromatin assembly or disassembly','P','Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly.','2013-10-27','NSRP'),(1073,1673,'male germ cell nucleus','C','The nucleus of a male germ cell, a reproductive cell in males.','2013-10-27','NSRP'),(1074,1674,'female germ cell nucleus','C','The nucleus of the female germ cell, a reproductive cell in females.','2013-10-27','NSRP'),(1075,1675,'acrosome assembly','P','The formation of the acrosome from the spermatid Golgi.','2013-10-27','NSRP'),(1076,1676,'long-chain fatty acid metabolic process','P','The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.','2013-10-27','NSRP'),(1077,1677,'formation of translation initiation ternary complex','P','Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).','2013-10-27','NSRP'),(1078,1678,'cellular glucose homeostasis','P','A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment.','2013-10-27','NSRP'),(1079,1680,'tRNA 3\'-terminal CCA addition','P','Post-transcriptional addition of the terminal 3\' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3\' end of the tRNA, yielding a diphosphate with each nucleotide addition.','2013-10-27','NSRP'),(1080,1681,'sialate O-acetylesterase activity','F','Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate.','2013-10-27','NSRP'),(1081,1682,'tRNA 5\'-leader removal','P','Generation of the mature 5\'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P.','2013-10-27','NSRP'),(1082,1683,'axonemal dynein heavy chain','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1083,1684,'axonemal dynein intermediate chain','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1084,1685,'axonemal dynein intermediate light chain','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1085,1686,'axonemal dynein light chain','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1086,1687,'cytoplasmic dynein heavy chain','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1087,1688,'cytoplasmic dynein intermediate chain','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1088,1689,'cytoplasmic dynein intermediate light chain','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1089,1690,'cytoplasmic dynein light chain','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(1090,1691,'pseudophosphatase activity','F','Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues.','2013-10-27','NSRP'),(1091,1692,'histamine metabolic process','P','The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.','2013-10-27','NSRP'),(1092,1694,'histamine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.','2013-10-27','NSRP'),(1093,1695,'histamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.','2013-10-27','NSRP'),(1094,1696,'gastric acid secretion','P','The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.','2013-10-27','NSRP'),(1095,1697,'histamine-induced gastric acid secretion','P','The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP.','2013-10-27','NSRP'),(1096,1698,'gastrin-induced gastric acid secretion','P','The regulated release of gastric acid induced by the interaction of gastrin with its receptor.','2013-10-27','NSRP'),(1097,1699,'acetylcholine-induced gastric acid secretion','P','The regulated release of gastric acid by parietal cells in response to acetylcholine.','2013-10-27','NSRP'),(1098,1700,'embryonic development via the syncytial blastoderm','P','The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(1099,1701,'in utero embryonic development','P','The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(1100,1702,'gastrulation with mouth forming second','P','A gastrulation process in which the initial invagination becomes the anus and the mouth forms second.','2013-10-27','NSRP'),(1101,1703,'gastrulation with mouth forming first','P','A gastrulation process in which the initial invagination becomes the mouth and the anus forms second.','2013-10-27','NSRP'),(1102,1704,'formation of primary germ layer','P','The formation of the ectoderm, mesoderm and endoderm during gastrulation.','2013-10-27','NSRP'),(1103,1705,'ectoderm formation','P','The formation of ectoderm during gastrulation.','2013-10-27','NSRP'),(1104,1706,'endoderm formation','P','The formation of the endoderm during gastrulation.','2013-10-27','NSRP'),(1105,1707,'mesoderm formation','P','The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts.','2013-10-27','NSRP'),(1106,1708,'cell fate specification','P','The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.','2013-10-27','NSRP'),(1107,1709,'cell fate determination','P','A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.','2013-10-27','NSRP'),(1108,1710,'mesodermal cell fate commitment','P','The cell differentiation process that results in commitment of a cell to become part of the mesoderm.','2013-10-27','NSRP'),(1109,1711,'endodermal cell fate commitment','P','The cell differentiation process that results in commitment of a cell to become part of the endoderm.','2013-10-27','NSRP'),(1110,1712,'ectodermal cell fate commitment','P','The cell differentiation process that results in commitment of a cell to become part of the ectoderm.','2013-10-27','NSRP'),(1111,1713,'ectodermal cell fate determination','P','The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(1112,1714,'endodermal cell fate specification','P','The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(1113,1715,'ectodermal cell fate specification','P','The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(1114,1716,'L-amino-acid oxidase activity','F','Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.','2013-10-27','NSRP'),(1115,1717,'conversion of seryl-tRNAsec to selenocys-tRNAsec','P','The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine.','2013-10-27','NSRP'),(1116,1720,'conversion of lysyl-tRNA to pyrrolysyl-tRNA','P','The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate).','2013-10-27','NSRP'),(1117,1721,'intermediate filament associated protein','C','OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks.','2013-10-27','NSRP'),(1118,1722,'type I intermediate filament associated protein','C','OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates.','2013-10-27','NSRP'),(1119,1723,'type II intermediate filament associated protein','C','OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks.','2013-10-27','NSRP'),(1120,1724,'type III intermediate filament associated protein','C','OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane.','2013-10-27','NSRP'),(1121,1725,'stress fiber','C','A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.','2013-10-27','NSRP'),(1122,1726,'ruffle','C','Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.','2013-10-27','NSRP'),(1123,1727,'lipid kinase activity','F','Catalysis of the phosphorylation of a simple or complex lipid.','2013-10-27','NSRP'),(1124,1729,'ceramide kinase activity','F','Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate.','2013-10-27','NSRP'),(1125,1730,'2\'-5\'-oligoadenylate synthetase activity','F','Catalysis of the reaction: ATP = pppA(2\'p5\'A)n oligomers. This reaction requires the binding of double-stranded RNA.','2013-10-27','NSRP'),(1126,1731,'formation of translation preinitiation complex','P','The joining of the small ribosomal subunit, ternary complex, and mRNA.','2013-10-27','NSRP'),(1127,1732,'formation of translation initiation complex','P','Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site.','2013-10-27','NSRP'),(1128,1733,'galactosylceramide sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + a galactosylceramide = adenosine 3\',5\'-bisphosphate + a galactosylceramidesulfate.','2013-10-27','NSRP'),(1129,1734,'mRNA (N6-adenosine)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U.','2013-10-27','NSRP'),(1130,1735,'prenylcysteine oxidase activity','F','Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2.','2013-10-27','NSRP'),(1131,1736,'establishment of planar polarity','P','Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.','2013-10-27','NSRP'),(1132,1737,'establishment of imaginal disc-derived wing hair orientation','P','Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.','2013-10-27','NSRP'),(1133,1738,'morphogenesis of a polarized epithelium','P','The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.','2013-10-27','NSRP'),(1134,1739,'sex chromatin','C','A condensed mass of compacted chromatin that represents an inactivated X chromosome.','2013-10-27','NSRP'),(1135,1740,'Barr body','C','A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.','2013-10-27','NSRP'),(1136,1741,'XY body','C','A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.','2013-10-27','NSRP'),(1137,1742,'oenocyte differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.','2013-10-27','NSRP'),(1138,1743,'optic placode formation','P','The initial developmental process that will lead to the formation of an eye.','2013-10-27','NSRP'),(1139,1744,'optic lobe placode formation','P','Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system.','2013-10-27','NSRP'),(1140,1745,'compound eye morphogenesis','P','The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.','2013-10-27','NSRP'),(1141,1746,'Bolwig\'s organ morphogenesis','P','The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig\'s organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain.','2013-10-27','NSRP'),(1142,1748,'optic lobe placode development','P','The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig\'s organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(1143,1750,'photoreceptor outer segment','C','The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes.','2013-10-27','NSRP'),(1144,1751,'compound eye photoreceptor cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.','2013-10-27','NSRP'),(1145,1752,'compound eye photoreceptor fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.','2013-10-27','NSRP'),(1146,1753,'adult eye photoreceptor development (sensu Drosophila)','P','OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye.','2013-10-27','NSRP'),(1147,1754,'eye photoreceptor cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.','2013-10-27','NSRP'),(1148,1755,'neural crest cell migration','P','The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.','2013-10-27','NSRP'),(1149,1756,'somitogenesis','P','The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.','2013-10-27','NSRP'),(1150,1757,'somite specification','P','The process in which individual somites establish identity during embryogenesis.','2013-10-27','NSRP'),(1151,1758,'retinal dehydrogenase activity','F','Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal.','2013-10-27','NSRP'),(1152,1759,'organ induction','P','The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.','2013-10-27','NSRP'),(1153,1760,'aminocarboxymuconate-semialdehyde decarboxylase activity','F','Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2).','2013-10-27','NSRP'),(1154,1761,'beta-alanine transmembrane transporter activity','F','Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid.','2013-10-27','NSRP'),(1155,1762,'beta-alanine transport','P','The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(1156,1763,'morphogenesis of a branching structure','P','The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.','2013-10-27','NSRP'),(1157,1764,'neuron migration','P','The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.','2013-10-27','NSRP'),(1158,1765,'membrane raft assembly','P','The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes.','2013-10-27','NSRP'),(1159,1766,'membrane raft polarization','P','The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes.','2013-10-27','NSRP'),(1160,1767,'establishment of lymphocyte polarity','P','The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.','2013-10-27','NSRP'),(1161,1768,'establishment of T cell polarity','P','The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.','2013-10-27','NSRP'),(1162,1769,'establishment of B cell polarity','P','The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell.','2013-10-27','NSRP'),(1163,1770,'establishment of natural killer cell polarity','P','The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands.','2013-10-27','NSRP'),(1164,1771,'immunological synapse formation','P','The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.','2013-10-27','NSRP'),(1165,1772,'immunological synapse','C','An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.','2013-10-27','NSRP'),(1166,1773,'myeloid dendritic cell activation','P','The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(1167,1774,'microglial cell activation','P','The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(1168,1775,'cell activation','P','A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.','2013-10-27','NSRP'),(1169,1776,'leukocyte homeostasis','P','The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.','2013-10-27','NSRP'),(1170,1777,'T cell homeostatic proliferation','P','The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.','2013-10-27','NSRP'),(1171,1778,'plasma membrane repair','P','The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress.','2013-10-27','NSRP'),(1172,1779,'natural killer cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.','2013-10-27','NSRP'),(1173,1780,'neutrophil homeostasis','P','The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.','2013-10-27','NSRP'),(1174,1781,'neutrophil apoptotic process','P','Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.','2013-10-27','NSRP'),(1175,1782,'B cell homeostasis','P','The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.','2013-10-27','NSRP'),(1176,1783,'B cell apoptotic process','P','Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.','2013-10-27','NSRP'),(1177,1784,'phosphotyrosine binding','F','Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.','2013-10-27','NSRP'),(1178,1785,'prostaglandin J receptor activity','F','Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity.','2013-10-27','NSRP'),(1179,1786,'phosphatidylserine binding','F','Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine.','2013-10-27','NSRP'),(1180,1787,'natural killer cell proliferation','P','The expansion of a natural killer cell population by cell division.','2013-10-27','NSRP'),(1181,1788,'antibody-dependent cellular cytotoxicity','P','Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.','2013-10-27','NSRP'),(1182,1789,'G-protein coupled receptor signaling pathway, coupled to S1P second messenger','P','The series of molecular signals generated as a consequence of an adrenergic receptor binding to its physiological ligand, where the pathway proceeds with activation of sphingosine kinase and a subsequent increase in cellular levels of sphingosine-1-phosphate (S1P).','2013-10-27','NSRP'),(1183,1790,'polymeric immunoglobulin binding','F','Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes.','2013-10-27','NSRP'),(1184,1791,'IgM binding','F','Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype.','2013-10-27','NSRP'),(1185,1792,'polymeric immunoglobulin receptor activity','F','Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1186,1793,'IgM receptor activity','F','Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1187,1794,'type IIa hypersensitivity','P','An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell.','2013-10-27','NSRP'),(1188,1795,'type IIb hypersensitivity','P','An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors.','2013-10-27','NSRP'),(1189,1796,'regulation of type IIa hypersensitivity','P','Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1190,1797,'negative regulation of type IIa hypersensitivity','P','Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1191,1798,'positive regulation of type IIa hypersensitivity','P','Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1192,1799,'regulation of type IIb hypersensitivity','P','Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1193,1800,'negative regulation of type IIb hypersensitivity','P','Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1194,1801,'positive regulation of type IIb hypersensitivity','P','Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1195,1802,'type III hypersensitivity','P','An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue.','2013-10-27','NSRP'),(1196,1803,'regulation of type III hypersensitivity','P','Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1197,1804,'negative regulation of type III hypersensitivity','P','Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1198,1805,'positive regulation of type III hypersensitivity','P','Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1199,1806,'type IV hypersensitivity','P','An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation.','2013-10-27','NSRP'),