(1200,1807,'regulation of type IV hypersensitivity','P','Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1201,1808,'negative regulation of type IV hypersensitivity','P','Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1202,1809,'positive regulation of type IV hypersensitivity','P','Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1203,1810,'regulation of type I hypersensitivity','P','Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1204,1811,'negative regulation of type I hypersensitivity','P','Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1205,1812,'positive regulation of type I hypersensitivity','P','Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.','2013-10-27','NSRP'),(1206,1813,'regulation of antibody-dependent cellular cytotoxicity','P','Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity.','2013-10-27','NSRP'),(1207,1814,'negative regulation of antibody-dependent cellular cytotoxicity','P','Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity.','2013-10-27','NSRP'),(1208,1815,'positive regulation of antibody-dependent cellular cytotoxicity','P','Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity.','2013-10-27','NSRP'),(1209,1816,'cytokine production','P','The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1210,1817,'regulation of cytokine production','P','Any process that modulates the frequency, rate, or extent of production of a cytokine.','2013-10-27','NSRP'),(1211,1818,'negative regulation of cytokine production','P','Any process that stops, prevents, or reduces the rate of production of a cytokine.','2013-10-27','NSRP'),(1212,1819,'positive regulation of cytokine production','P','Any process that activates or increases the frequency, rate or extent of production of a cytokine.','2013-10-27','NSRP'),(1213,1820,'serotonin secretion','P','The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.','2013-10-27','NSRP'),(1214,1821,'histamine secretion','P','The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.','2013-10-27','NSRP'),(1215,1822,'kidney development','P','The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.','2013-10-27','NSRP'),(1216,1823,'mesonephros development','P','The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.','2013-10-27','NSRP'),(1217,1824,'blastocyst development','P','The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm.','2013-10-27','NSRP'),(1218,1825,'blastocyst formation','P','The initial formation of a blastocyst from a solid ball of cells known as a morula.','2013-10-27','NSRP'),(1219,1826,'inner cell mass cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.','2013-10-27','NSRP'),(1220,1827,'inner cell mass cell fate commitment','P','The cell fate commitment of precursor cells that will become inner cell mass cells.','2013-10-27','NSRP'),(1221,1828,'inner cell mass cellular morphogenesis','P','The morphogenesis of cells in the inner cell mass.','2013-10-27','NSRP'),(1222,1829,'trophectodermal cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.','2013-10-27','NSRP'),(1223,1830,'trophectodermal cell fate commitment','P','The cell fate commitment of precursor cells that will become trophectoderm cells.','2013-10-27','NSRP'),(1224,1831,'trophectodermal cellular morphogenesis','P','The morphogenesis of trophectoderm cells.','2013-10-27','NSRP'),(1225,1832,'blastocyst growth','P','An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.','2013-10-27','NSRP'),(1226,1833,'inner cell mass cell proliferation','P','The proliferation of cells in the inner cell mass.','2013-10-27','NSRP'),(1227,1834,'trophectodermal cell proliferation','P','The proliferation of cells in the trophectoderm.','2013-10-27','NSRP'),(1228,1835,'blastocyst hatching','P','The hatching of the cellular blastocyst from the zona pellucida.','2013-10-27','NSRP'),(1229,1836,'release of cytochrome c from mitochondria','P','The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.','2013-10-27','NSRP'),(1230,1837,'epithelial to mesenchymal transition','P','A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.','2013-10-27','NSRP'),(1231,1838,'embryonic epithelial tube formation','P','The morphogenesis of an embryonic epithelium into a tube-shaped structure.','2013-10-27','NSRP'),(1232,1839,'neural plate morphogenesis','P','The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue.','2013-10-27','NSRP'),(1233,1840,'neural plate development','P','The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.','2013-10-27','NSRP'),(1234,1841,'neural tube formation','P','The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.','2013-10-27','NSRP'),(1235,1842,'neural fold formation','P','The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove.','2013-10-27','NSRP'),(1236,1843,'neural tube closure','P','The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.','2013-10-27','NSRP'),(1237,1844,'protein insertion into mitochondrial membrane involved in apoptotic signaling pathway','P','The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway.','2013-10-27','NSRP'),(1238,1845,'phagolysosome assembly','P','The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome.','2013-10-27','NSRP'),(1239,1846,'opsonin binding','F','Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material.','2013-10-27','NSRP'),(1240,1847,'opsonin receptor activity','F','Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1241,1848,'complement binding','F','Interacting selectively and non-covalently with any component or product of the complement cascade.','2013-10-27','NSRP'),(1242,1849,'complement component C1q binding','F','Interacting selectively and non-covalently with the C1q component of the classical complement cascade.','2013-10-27','NSRP'),(1243,1850,'complement component C3a binding','F','Interacting selectively and non-covalently with the C3a product of the complement cascade.','2013-10-27','NSRP'),(1244,1851,'complement component C3b binding','F','Interacting selectively and non-covalently with the C3b product of the complement cascade.','2013-10-27','NSRP'),(1245,1852,'complement component iC3b binding','F','Interacting selectively and non-covalently with the iC3b product of the complement cascade.','2013-10-27','NSRP'),(1246,1853,'complement component C3dg binding','F','Interacting selectively and non-covalently with the C3dg product of the complement cascade.','2013-10-27','NSRP'),(1247,1854,'complement component C3d binding','F','Interacting selectively and non-covalently with the C3d product of the complement cascade.','2013-10-27','NSRP'),(1248,1855,'complement component C4b binding','F','Interacting selectively and non-covalently with the C4b product of the classical complement cascade.','2013-10-27','NSRP'),(1249,1856,'complement component C5a binding','F','Interacting selectively and non-covalently with the C5a product of the complement cascade.','2013-10-27','NSRP'),(1250,1857,'complement component C1q receptor activity','F','Combining with the C1q component of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1251,1858,'complement component iC3b receptor activity','F','Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1252,1859,'complement component C3dg receptor activity','F','Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1253,1860,'complement component C3d receptor activity','F','Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1254,1861,'complement component C4b receptor activity','F','Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1255,1862,'collectin binding','F','Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus.','2013-10-27','NSRP'),(1256,1863,'collectin receptor activity','F','Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1257,1864,'pentraxin binding','F','Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array.','2013-10-27','NSRP'),(1258,1865,'NK T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a NK T cell.','2013-10-27','NSRP'),(1259,1866,'NK T cell proliferation','P','The expansion of a NK T cell population by cell division.','2013-10-27','NSRP'),(1260,1867,'complement activation, lectin pathway','P','Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.','2013-10-27','NSRP'),(1261,1868,'regulation of complement activation, lectin pathway','P','Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation.','2013-10-27','NSRP'),(1262,1869,'negative regulation of complement activation, lectin pathway','P','Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway.','2013-10-27','NSRP'),(1263,1870,'positive regulation of complement activation, lectin pathway','P','Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway.','2013-10-27','NSRP'),(1264,1871,'pattern binding','F','Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan.','2013-10-27','NSRP'),(1265,1872,'(1->3)-beta-D-glucan binding','F','Interacting selectively and non-covalently with (1->3)-beta-D-glucans.','2013-10-27','NSRP'),(1266,1873,'polysaccharide receptor activity','F','Combining with a polysaccharide and transmitting the signal to initiate a change in cell activity. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.','2013-10-27','NSRP'),(1267,1874,'(1->3)-beta-D-glucan receptor activity','F','Combining with (1->3)-beta-D-glucans to initiate a change in cell activity.','2013-10-27','NSRP'),(1268,1875,'lipopolysaccharide receptor activity','F','Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.','2013-10-27','NSRP'),(1269,1876,'lipoarabinomannan binding','F','Interacting selectively and non-covalently with lipoarabinomannan.','2013-10-27','NSRP'),(1270,1877,'lipoarabinomannan receptor activity','F','Combining with lipoarabinomannan and transmitting the signal to initiate a change in cell activity.','2013-10-27','NSRP'),(1271,1878,'response to yeast','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species.','2013-10-27','NSRP'),(1272,1879,'detection of yeast','P','The series of events in which a stimulus from a yeast is received and converted into a molecular signal.','2013-10-27','NSRP'),(1273,1880,'Mullerian duct regression','P','The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos.','2013-10-27','NSRP'),(1274,1881,'receptor recycling','P','The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.','2013-10-27','NSRP'),(1275,1882,'nucleoside binding','F','Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.','2013-10-27','NSRP'),(1276,1883,'purine nucleoside binding','F','Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.','2013-10-27','NSRP'),(1277,1884,'pyrimidine nucleoside binding','F','Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose.','2013-10-27','NSRP'),(1278,1885,'endothelial cell development','P','The progression of an endothelial cell over time, from its formation to the mature structure.','2013-10-27','NSRP'),(1279,1886,'endothelial cell morphogenesis','P','The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.','2013-10-27','NSRP'),(1280,1887,'selenium compound metabolic process','P','The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine.','2013-10-27','NSRP'),(1281,1888,'glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan.','2013-10-27','NSRP'),(1282,1889,'liver development','P','The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.','2013-10-27','NSRP'),(1283,1890,'placenta development','P','The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.','2013-10-27','NSRP'),(1284,1891,'phagocytic cup','C','An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.','2013-10-27','NSRP'),(1285,1892,'embryonic placenta development','P','The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.','2013-10-27','NSRP'),(1286,1893,'maternal placenta development','P','Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.','2013-10-27','NSRP'),(1287,1894,'tissue homeostasis','P','A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.','2013-10-27','NSRP'),(1288,1895,'retina homeostasis','P','A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function.','2013-10-27','NSRP'),(1289,1896,'autolysis','P','The spontaneous death by lysis of bacteria in response to environmental conditions.','2013-10-27','NSRP'),(1290,1897,'cytolysis by symbiont of host cells','P','The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(1291,1898,'regulation of cytolysis by symbiont of host cells','P','Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(1292,1899,'negative regulation of cytolysis by symbiont of host cells','P','Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(1293,1900,'positive regulation of cytolysis by symbiont of host cells','P','Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(1294,1905,'activation of membrane attack complex','P','The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis.','2013-10-27','NSRP'),(1295,1906,'cell killing','P','Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.','2013-10-27','NSRP'),(1296,1907,'killing by symbiont of host cells','P','Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(1297,1909,'leukocyte mediated cytotoxicity','P','The directed killing of a target cell by a leukocyte.','2013-10-27','NSRP'),(1298,1910,'regulation of leukocyte mediated cytotoxicity','P','Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity.','2013-10-27','NSRP'),(1299,1911,'negative regulation of leukocyte mediated cytotoxicity','P','Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity.','2013-10-27','NSRP'),(1300,1912,'positive regulation of leukocyte mediated cytotoxicity','P','Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity.','2013-10-27','NSRP'),(1301,1913,'T cell mediated cytotoxicity','P','The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.','2013-10-27','NSRP'),(1302,1914,'regulation of T cell mediated cytotoxicity','P','Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity.','2013-10-27','NSRP'),(1303,1915,'negative regulation of T cell mediated cytotoxicity','P','Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.','2013-10-27','NSRP'),(1304,1916,'positive regulation of T cell mediated cytotoxicity','P','Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity.','2013-10-27','NSRP'),(1305,1917,'photoreceptor inner segment','C','The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.','2013-10-27','NSRP'),(1306,1918,'farnesylated protein binding','F','Interacting selectively and non-covalently with a farnesylated protein.','2013-10-27','NSRP'),(1307,1919,'regulation of receptor recycling','P','Any process that modulates the frequency, rate, or extent of receptor recycling.','2013-10-27','NSRP'),(1308,1920,'negative regulation of receptor recycling','P','Any process that stops, prevents, or reduces the rate of receptor recycling.','2013-10-27','NSRP'),(1309,1921,'positive regulation of receptor recycling','P','Any process that activates or increases the frequency, rate or extent of receptor recycling.','2013-10-27','NSRP'),(1310,1922,'B-1 B cell homeostasis','P','The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.','2013-10-27','NSRP'),(1311,1923,'B-1 B cell differentiation','P','The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.','2013-10-27','NSRP'),(1312,1924,'regulation of B-1 B cell differentiation','P','Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.','2013-10-27','NSRP'),(1313,1925,'negative regulation of B-1 B cell differentiation','P','Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation.','2013-10-27','NSRP'),(1314,1926,'positive regulation of B-1 B cell differentiation','P','Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation.','2013-10-27','NSRP'),(1315,1927,'exocyst assembly','P','The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex.','2013-10-27','NSRP'),(1316,1928,'regulation of exocyst assembly','P','Any process that modulates the frequency, rate or extent of exocyst assembly.','2013-10-27','NSRP'),(1317,1929,'negative regulation of exocyst assembly','P','Any process that stops, prevents, or reduces the rate or extent of exocyst assembly.','2013-10-27','NSRP'),(1318,1930,'positive regulation of exocyst assembly','P','Any process that increases the rate or extent of exocyst assembly.','2013-10-27','NSRP'),(1319,1931,'uropod','C','A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.','2013-10-27','NSRP'),(1320,1932,'regulation of protein phosphorylation','P','Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.','2013-10-27','NSRP'),(1321,1933,'negative regulation of protein phosphorylation','P','Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.','2013-10-27','NSRP'),(1322,1934,'positive regulation of protein phosphorylation','P','Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.','2013-10-27','NSRP'),(1323,1935,'endothelial cell proliferation','P','The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.','2013-10-27','NSRP'),(1324,1936,'regulation of endothelial cell proliferation','P','Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.','2013-10-27','NSRP'),(1325,1937,'negative regulation of endothelial cell proliferation','P','Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.','2013-10-27','NSRP'),(1326,1938,'positive regulation of endothelial cell proliferation','P','Any process that activates or increases the rate or extent of endothelial cell proliferation.','2013-10-27','NSRP'),(1327,1939,'female pronucleus','C','The pronucleus originating from the ovum that is being fertilized.','2013-10-27','NSRP'),(1328,1940,'male pronucleus','C','The pronucleus originating from the spermatozoa that was involved in fertilization.','2013-10-27','NSRP'),(1329,1941,'postsynaptic membrane organization','P','The maintenance of membrane composition in a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).','2013-10-27','NSRP'),(1330,1942,'hair follicle development','P','The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.','2013-10-27','NSRP'),(1331,1944,'vasculature development','P','The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.','2013-10-27','NSRP'),(1332,1945,'lymph vessel development','P','The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.','2013-10-27','NSRP'),(1333,1946,'lymphangiogenesis','P','Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.','2013-10-27','NSRP'),(1334,1947,'heart looping','P','The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.','2013-10-27','NSRP'),(1335,1948,'glycoprotein binding','F','Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans.','2013-10-27','NSRP'),(1336,1949,'sebaceous gland cell differentiation','P','The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell.','2013-10-27','NSRP'),(1337,1950,'plasma membrane enriched fraction','C','OBSOLETE: The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes.','2013-10-27','NSRP'),(1338,1951,'intestinal D-glucose absorption','P','Uptake of D-glucose into the blood by absorption from the small intestine.','2013-10-27','NSRP'),(1339,1952,'regulation of cell-matrix adhesion','P','Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.','2013-10-27','NSRP'),(1340,1953,'negative regulation of cell-matrix adhesion','P','Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix.','2013-10-27','NSRP'),(1341,1954,'positive regulation of cell-matrix adhesion','P','Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.','2013-10-27','NSRP'),(1342,1955,'blood vessel maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.','2013-10-27','NSRP'),(1343,1956,'positive regulation of neurotransmitter secretion','P','Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.','2013-10-27','NSRP'),(1344,1957,'intramembranous ossification','P','Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.','2013-10-27','NSRP'),(1345,1958,'endochondral ossification','P','Replacement ossification wherein bone tissue replaces cartilage.','2013-10-27','NSRP'),(1346,1959,'regulation of cytokine-mediated signaling pathway','P','Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway.','2013-10-27','NSRP'),(1347,1960,'negative regulation of cytokine-mediated signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.','2013-10-27','NSRP'),(1348,1961,'positive regulation of cytokine-mediated signaling pathway','P','Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway.','2013-10-27','NSRP'),(1349,1962,'alpha-1,3-galactosyltransferase activity','F','Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage.','2013-10-27','NSRP'),(1350,1963,'synaptic transmission, dopaminergic','P','The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.','2013-10-27','NSRP'),(1351,1964,'startle response','P','An action or movement due to the application of a sudden unexpected stimulus.','2013-10-27','NSRP'),(1352,1965,'G-protein alpha-subunit binding','F','Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.','2013-10-27','NSRP'),(1353,1966,'thigmotaxis','P','The directed movement of a motile cell or organism in response to touch.','2013-10-27','NSRP'),(1354,1967,'suckling behavior','P','Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast.','2013-10-27','NSRP'),(1355,1968,'fibronectin binding','F','Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.','2013-10-27','NSRP'),(1356,1969,'regulation of activation of membrane attack complex','P','Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.','2013-10-27','NSRP'),(1357,1970,'positive regulation of activation of membrane attack complex','P','Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.','2013-10-27','NSRP'),(1358,1971,'negative regulation of activation of membrane attack complex','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade.','2013-10-27','NSRP'),(1359,1972,'retinoic acid binding','F','Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid.','2013-10-27','NSRP'),(1360,1973,'adenosine receptor signaling pathway','P','The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.','2013-10-27','NSRP'),(1361,1974,'blood vessel remodeling','P','The reorganization or renovation of existing blood vessels.','2013-10-27','NSRP'),(1362,1975,'response to amphetamine','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine.','2013-10-27','NSRP'),(1363,1976,'neurological system process involved in regulation of systemic arterial blood pressure','P','The regulation of blood pressure mediated by detection of stimuli and a neurological response.','2013-10-27','NSRP'),(1364,1977,'renal system process involved in regulation of blood volume','P','A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system.','2013-10-27','NSRP'),(1365,1978,'regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback','P','The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control.','2013-10-27','NSRP'),(1366,1979,'regulation of systemic arterial blood pressure by chemoreceptor signaling','P','The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.','2013-10-27','NSRP'),(1367,1980,'regulation of systemic arterial blood pressure by ischemic conditions','P','The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system.','2013-10-27','NSRP'),(1368,1981,'baroreceptor detection of arterial stretch','P','The series of events by which the change in diameter of an artery is detected and converted to a molecular signal.','2013-10-27','NSRP'),(1369,1982,'baroreceptor response to decreased systemic arterial blood pressure','P','The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels.','2013-10-27','NSRP'),(1370,1983,'baroreceptor response to increased systemic arterial blood pressure','P','The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels.','2013-10-27','NSRP'),(1371,1984,'vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure','P','An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure.','2013-10-27','NSRP'),(1372,1985,'negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure','P','Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure.','2013-10-27','NSRP'),(1373,1986,'negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure','P','Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure.','2013-10-27','NSRP'),(1374,1987,'vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure','P','A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure.','2013-10-27','NSRP'),(1375,1988,'positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure','P','Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure.','2013-10-27','NSRP'),(1376,1989,'positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure','P','Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure.','2013-10-27','NSRP'),(1377,1990,'regulation of systemic arterial blood pressure by hormone','P','The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.','2013-10-27','NSRP'),(1378,1991,'regulation of systemic arterial blood pressure by circulatory renin-angiotensin','P','The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen.','2013-10-27','NSRP'),(1379,1992,'regulation of systemic arterial blood pressure by vasopressin','P','The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport.','2013-10-27','NSRP'),(1380,1993,'regulation of systemic arterial blood pressure by norepinephrine-epinephrine','P','The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system.','2013-10-27','NSRP'),(1381,1994,'norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure','P','A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure.','2013-10-27','NSRP'),(1382,1995,'norepinephrine-epinephrine catabolic process in blood stream','P','The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream.','2013-10-27','NSRP'),(1383,1996,'positive regulation of heart rate by epinephrine-norepinephrine','P','The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.','2013-10-27','NSRP'),(1384,1997,'positive regulation of the force of heart contraction by epinephrine-norepinephrine','P','Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings.','2013-10-27','NSRP'),(1385,1998,'angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure','P','The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream.','2013-10-27','NSRP'),(1386,1999,'renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure','P','The physiological response of the kidneys to a decrease in blood flow.','2013-10-27','NSRP'),(1387,2000,'detection of renal blood flow','P','The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal.','2013-10-27','NSRP'),(1388,2001,'renin secretion into blood stream','P','The regulated release of renin into the blood stream by juxtoglomerular cells.','2013-10-27','NSRP'),(1389,2002,'regulation of angiotensin levels in blood','P','The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin.','2013-10-27','NSRP'),(1390,2003,'angiotensin maturation','P','The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood.','2013-10-27','NSRP'),(1391,2004,'secretion of vasopressin involved in fast regulation of systemic arterial blood pressure','P','The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure.','2013-10-27','NSRP'),(1392,2005,'angiotensin catabolic process in blood','P','The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood.','2013-10-27','NSRP'),(1393,2006,'vasoconstriction by vasopressin involved in systemic arterial blood pressure control','P','The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream.','2013-10-27','NSRP'),(1394,2007,'detection of hypoxic conditions in blood by chemoreceptor signaling','P','The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.','2013-10-27','NSRP'),(1395,2008,'excitation of vasomotor center by chemoreceptor signaling','P','The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure.','2013-10-27','NSRP'),(1396,2009,'morphogenesis of an epithelium','P','The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.','2013-10-27','NSRP'),(1397,2010,'excitation of vasomotor center by baroreceptor signaling','P','The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure.','2013-10-27','NSRP'),(1398,2011,'morphogenesis of an epithelial sheet','P','The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.','2013-10-27','NSRP'),(1399,2012,'vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure','P','A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.','2013-10-27','NSRP'),(1400,2013,'detection of carbon dioxide by vasomotor center','P','The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system.','2013-10-27','NSRP'),(1401,2014,'vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure','P','The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system.','2013-10-27','NSRP'),(1402,2015,'regulation of systemic arterial blood pressure by atrial baroreceptor feedback','P','A process that controls blood pressure by sensing the amount of stretch occurring in the atria.','2013-10-27','NSRP'),(1403,2016,'regulation of blood volume by renin-angiotensin','P','The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood.','2013-10-27','NSRP'),(1404,2017,'regulation of blood volume by renal aldosterone','P','The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume.','2013-10-27','NSRP'),(1405,2018,'renin-angiotensin regulation of aldosterone production','P','The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone.','2013-10-27','NSRP'),(1406,2019,'regulation of renal output by angiotensin','P','The process in which angiotensin directly modulates the rate of urine output by the kidney.','2013-10-27','NSRP'),(1407,2020,'protease binding','F','Interacting selectively and non-covalently with any protease or peptidase.','2013-10-27','NSRP'),(1408,2021,'response to dietary excess','P','The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.','2013-10-27','NSRP'),(1409,2022,'detection of dietary excess','P','The neurological process in which the brain senses excessive caloric intake.','2013-10-27','NSRP'),(1410,2023,'reduction of food intake in response to dietary excess','P','The specific actions of an organism that are triggered by the detection of dietary excess and result in a decreased intake of food.','2013-10-27','NSRP'),(1411,2024,'diet induced thermogenesis','P','The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system.','2013-10-27','NSRP'),(1412,2025,'vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure','P','A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change.','2013-10-27','NSRP'),(1413,2026,'regulation of the force of heart contraction','P','Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.','2013-10-27','NSRP'),(1414,2027,'regulation of heart rate','P','Any process that modulates the frequency or rate of heart contraction.','2013-10-27','NSRP'),(1415,2028,'regulation of sodium ion transport','P','Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(1416,2029,'desensitization of G-protein coupled receptor protein signaling pathway','P','The process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway.','2013-10-27','NSRP'),(1417,2030,'inhibitory G-protein coupled receptor phosphorylation','P','The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site.','2013-10-27','NSRP'),(1418,2031,'G-protein coupled receptor internalization','P','The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle.','2013-10-27','NSRP'),(1419,2032,'desensitization of G-protein coupled receptor protein signaling pathway by arrestin','P','The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins.','2013-10-27','NSRP'),(1420,2033,'vasodilation by angiotensin involved in regulation of systemic arterial blood pressure','P','The process that increases the size of a blood vessel via the renin-angiotensin system.','2013-10-27','NSRP'),(1421,2034,'regulation of blood vessel size by renin-angiotensin','P','The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system.','2013-10-27','NSRP'),(1422,2035,'brain renin-angiotensin system','P','The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system.','2013-10-27','NSRP'),(1423,2036,'regulation of L-glutamate transport','P','Any process that modulates the frequency, rate or extent of L-glutamate transport.','2013-10-27','NSRP'),(1424,2037,'negative regulation of L-glutamate transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate transport.','2013-10-27','NSRP'),(1425,2038,'positive regulation of L-glutamate transport','P','Any process that activates or increases the frequency, rate or extent of L-glutamate transport.','2013-10-27','NSRP'),(1426,2039,'p53 binding','F','Interacting selectively and non-covalently with one of the p53 family of proteins.','2013-10-27','NSRP'),(1427,2040,'sprouting angiogenesis','P','The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells.','2013-10-27','NSRP'),(1428,2041,'intussusceptive angiogenesis','P','The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars.','2013-10-27','NSRP'),(1429,2042,'cell migration involved in sprouting angiogenesis','P','The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.','2013-10-27','NSRP'),(1430,2043,'blood vessel endothelial cell proliferation involved in sprouting angiogenesis','P','The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.','2013-10-27','NSRP'),(1431,2044,'blood vessel endothelial cell migration involved in intussusceptive angiogenesis','P','The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis.','2013-10-27','NSRP'),(1432,2045,'regulation of cell adhesion involved in intussusceptive angiogenesis','P','The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis.','2013-10-27','NSRP'),(1433,2046,'opsin binding','F','Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception.','2013-10-27','NSRP'),(1434,2047,'phenazine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring.','2013-10-27','NSRP'),(1435,2048,'pyoverdine metabolic process','P','The chemical reactions and pathways involving the siderochrome pyoverdine.','2013-10-27','NSRP'),(1436,2049,'pyoverdine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine.','2013-10-27','NSRP'),(1437,2050,'pyoverdine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine.','2013-10-27','NSRP'),(1438,2051,'osteoblast fate commitment','P','The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone.','2013-10-27','NSRP'),(1439,2052,'positive regulation of neuroblast proliferation','P','Any process that activates or increases the rate of neuroblast proliferation.','2013-10-27','NSRP'),(1440,2053,'positive regulation of mesenchymal cell proliferation','P','The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.','2013-10-27','NSRP'),(1441,2054,'nucleobase binding','F','Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases.','2013-10-27','NSRP'),(1442,2055,'adenine binding','F','Interacting selectively and non-covalently with adenine, a purine base.','2013-10-27','NSRP'),(1443,2056,'cytosine binding','F','Interacting selectively and non-covalently with cytosine.','2013-10-27','NSRP'),(1444,2057,'guanine binding','F','Interacting selectively and non-covalently with guanine.','2013-10-27','NSRP'),(1445,2058,'uracil binding','F','Interacting selectively and non-covalently with uracil.','2013-10-27','NSRP'),(1446,2059,'thymine binding','F','Interacting selectively and non-covalently with thymine.','2013-10-27','NSRP'),(1447,2060,'purine nucleobase binding','F','Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton.','2013-10-27','NSRP'),(1448,2061,'pyrimidine nucleobase binding','F','Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton.','2013-10-27','NSRP'),(1449,2062,'chondrocyte differentiation','P','The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.','2013-10-27','NSRP'),(1450,2063,'chondrocyte development','P','The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.','2013-10-27','NSRP'),(1451,2064,'epithelial cell development','P','The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.','2013-10-27','NSRP'),(1452,2065,'columnar/cuboidal epithelial cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.','2013-10-27','NSRP'),(1453,2066,'columnar/cuboidal epithelial cell development','P','The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.','2013-10-27','NSRP'),(1454,2067,'glandular epithelial cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.','2013-10-27','NSRP'),(1455,2068,'glandular epithelial cell development','P','The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.','2013-10-27','NSRP'),(1456,2069,'columnar/cuboidal epithelial cell maturation','P','The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.','2013-10-27','NSRP'),(1457,2070,'epithelial cell maturation','P','The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.','2013-10-27','NSRP'),(1458,2071,'glandular epithelial cell maturation','P','The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.','2013-10-27','NSRP'),(1459,2072,'optic cup morphogenesis involved in camera-type eye development','P','The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(1460,2074,'extraocular skeletal muscle development','P','The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(1461,2075,'somitomeric trunk muscle development','P','The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(1462,2076,'osteoblast development','P','The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.','2013-10-27','NSRP'),(1463,2077,'acrosome matrix dispersal','P','The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg.','2013-10-27','NSRP'),(1464,2078,'membrane fusion involved in acrosome reaction','P','The fusion of the plasma membrane of the sperm with the outer acrosomal membrane.','2013-10-27','NSRP'),(1465,2079,'inner acrosomal membrane','C','The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane.','2013-10-27','NSRP'),(1466,2080,'acrosomal membrane','C','The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.','2013-10-27','NSRP'),(1467,2081,'outer acrosomal membrane','C','The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction.','2013-10-27','NSRP'),(1468,2082,'regulation of oxidative phosphorylation','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.','2013-10-27','NSRP'),(1469,2083,'4-hydroxybenzoate decaprenyltransferase activity','F','Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate.','2013-10-27','NSRP'),(1470,2084,'protein depalmitoylation','P','The removal of palymitoyl groups from a lipoprotein.','2013-10-27','NSRP'),(1471,2085,'inhibition of neuroepithelial cell differentiation','P','Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.','2013-10-27','NSRP'),(1472,2086,'diaphragm contraction','P','A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange.','2013-10-27','NSRP'),(1473,2087,'regulation of respiratory gaseous exchange by neurological system process','P','A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.','2013-10-27','NSRP'),(1474,2088,'lens development in camera-type eye','P','The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(1475,2089,'lens morphogenesis in camera-type eye','P','The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(1476,2090,'regulation of receptor internalization','P','Any process that modulates the frequency, rate or extent of receptor internalization.','2013-10-27','NSRP'),(1477,2091,'negative regulation of receptor internalization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization.','2013-10-27','NSRP'),(1478,2092,'positive regulation of receptor internalization','P','Any process that activates or increases the frequency, rate or extent of receptor internalization.','2013-10-27','NSRP'),(1479,2093,'auditory receptor cell morphogenesis','P','Any process that alters the size or shape of an auditory receptor cell.','2013-10-27','NSRP'),(1480,2094,'polyprenyltransferase activity','F','Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor).','2013-10-27','NSRP'),(1481,2095,'caveolar macromolecular signaling complex','C','A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3).','2013-10-27','NSRP'),(1482,2096,'polkadots','C','A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals.','2013-10-27','NSRP'),(1483,2097,'tRNA wobble base modification','P','The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified.','2013-10-27','NSRP'),(1484,2098,'tRNA wobble uridine modification','P','The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified.','2013-10-27','NSRP'),(1485,2099,'tRNA wobble guanine modification','P','The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified.','2013-10-27','NSRP'),(1486,2100,'tRNA wobble adenosine to inosine editing','P','The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine.','2013-10-27','NSRP'),(1487,2101,'tRNA wobble cytosine modification','P','The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified.','2013-10-27','NSRP'),(1488,2102,'podosome','C','An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm.','2013-10-27','NSRP'),(1489,2103,'endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)','P','Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5\' to 3\' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.','2013-10-27','NSRP'),(1490,2104,'endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)','P','Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5\' to 3\' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.','2013-10-27','NSRP'),(1491,2105,'endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)','P','Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5\' to 3\' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.','2013-10-27','NSRP'),(1492,2106,'endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)','P','Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5\' to 3\' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript.','2013-10-27','NSRP'),(1493,2107,'generation of mature 3\'-end of 5S rRNA generated by RNA polymerase III','P','The removal of extra uridine residues from the 3\' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3\'-end.','2013-10-27','NSRP'),(1494,2108,'maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)','P','Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(1495,2109,'maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)','P','Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5\' to 3\' along the primary transcript.','2013-10-27','NSRP'),(1496,2110,'cotranscriptional mitochondrial rRNA nucleotide insertion','P','The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis.','2013-10-27','NSRP'),(1497,2111,'BRCA2-BRAF35 complex','C','A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis.','2013-10-27','NSRP'),(1498,2112,'interleukin-33 receptor binding','F','Interacting selectively and non-covalently with the interleukin-33 receptor.','2013-10-27','NSRP'),(1499,2113,'interleukin-33 binding','F','Interacting selectively and non-covalently with interleukin-33.','2013-10-27','NSRP'),(1500,2114,'interleukin-33 receptor activity','F','Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1501,2115,'store-operated calcium entry','P','A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum.','2013-10-27','NSRP'),(1502,2116,'semaphorin receptor complex','C','A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor.','2013-10-27','NSRP'),(1503,2117,'amphibian larval development','P','The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form.','2013-10-27','NSRP'),(1504,2118,'aggressive behavior','P','A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.','2013-10-27','NSRP'),(1505,2119,'nematode larval development','P','The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.','2013-10-27','NSRP'),(1506,2120,'predatory behavior','P','Aggressive behavior involving attack on prey by a predator.','2013-10-27','NSRP'),(1507,2121,'inter-male aggressive behavior','P','Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.','2013-10-27','NSRP'),(1508,2122,'fear-induced aggressive behavior','P','Aggressive behavior associated with attempts to flee from a threat.','2013-10-27','NSRP'),(1509,2123,'irritable aggressive behavior','P','Aggressive behavior induced by frustration and directed against an available target.','2013-10-27','NSRP'),(1510,2124,'territorial aggressive behavior','P','Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics.','2013-10-27','NSRP'),(1511,2125,'maternal aggressive behavior','P','Aggressive behavior of a female to protect her offspring from a threat.','2013-10-27','NSRP'),(1512,2126,'instrumental aggressive behavior','P','Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation.','2013-10-27','NSRP'),(1513,2127,'wobble base cytosine methylation','P','The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position.','2013-10-27','NSRP'),(1514,2128,'tRNA nucleoside ribose methylation','P','The process that results in the modification of the sugar of a nucleoside in tRNA at the 2\'O position.','2013-10-27','NSRP'),(1515,2129,'wobble position guanine ribose methylation','P','The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2\'-O position.','2013-10-27','NSRP'),(1516,2130,'wobble position ribose methylation','P','The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2\'O position.','2013-10-27','NSRP'),(1517,2131,'wobble position cytosine ribose methylation','P','The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2\'-O position.','2013-10-27','NSRP'),(1518,2132,'wobble position uridine ribose methylation','P','The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2\'-O position.','2013-10-27','NSRP'),(1519,2133,'polycystin complex','C','A stable heterodimeric complex composed of polycystin-1 and polycystin-2.','2013-10-27','NSRP'),(1520,2134,'UTP binding','F','Interacting selectively and non-covalently with UTP, uridine 5\'-triphosphate.','2013-10-27','NSRP'),(1521,2135,'CTP binding','F','Interacting selectively and non-covalently with CTP, cytidine 5\'-triphosphate.','2013-10-27','NSRP'),(1522,2136,'wobble base lysidine biosynthesis','P','The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine.','2013-10-27','NSRP'),(1523,2137,'nuclear cluster','C','Discrete hetero-chromatin-containing foci in interphase nuclei, which comprise clusters of centromeric DNA (as defined by gamma-satellite sequences and the abundance of heterochromatin protein 1 (HP-1).','2013-10-27','NSRP'),(1524,2138,'retinoic acid biosynthetic process','P','The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A.','2013-10-27','NSRP'),(1525,2139,'stereocilia coupling link','C','A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle.','2013-10-27','NSRP'),(1526,2140,'stereocilia tip link','C','A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia.','2013-10-27','NSRP'),(1527,2141,'stereocilia ankle link','C','A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia.','2013-10-27','NSRP'),(1528,2142,'stereocilia ankle link complex','C','A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin.','2013-10-27','NSRP'),(1529,2143,'tRNA wobble position uridine thiolation','P','The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps.','2013-10-27','NSRP'),(1530,2144,'cytosolic tRNA wobble base thiouridylase complex','C','A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes.','2013-10-27','NSRP'),(1531,2145,'4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity','F','Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+).','2013-10-27','NSRP'),(1532,2146,'steroid hormone receptor import into nucleus','P','The directed movement of a steroid hormone receptor into the nucleus.','2013-10-27','NSRP'),(1533,2147,'glucocorticoid receptor import into nucleus','P','The directed movement of a glucocorticoid receptor into the nucleus.','2013-10-27','NSRP'),(1534,2148,'hypochlorous acid metabolic process','P','The chemical reactions and pathways involving hypochlorous acid.','2013-10-27','NSRP'),(1535,2149,'hypochlorous acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of hypochlorous acid.','2013-10-27','NSRP'),(1536,2150,'hypochlorous acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of hypochlorous acid.','2013-10-27','NSRP'),(1537,2151,'G-quadruplex RNA binding','F','Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad.','2013-10-27','NSRP'),(1538,2152,'bile acid conjugation','P','The process in which bile acids are covalently linked to taurine or glycine.','2013-10-27','NSRP'),(1539,2153,'steroid receptor RNA activator RNA binding','F','Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding.','2013-10-27','NSRP'),(1540,2154,'thyroid hormone mediated signaling pathway','P','A series of molecular signals mediated by the detection of a thyroid hormone.','2013-10-27','NSRP'),(1541,2155,'regulation of thyroid hormone mediated signaling pathway','P','Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway.','2013-10-27','NSRP'),(1542,2156,'negative regulation of thyroid hormone mediated signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway.','2013-10-27','NSRP'),(1543,2157,'positive regulation of thyroid hormone mediated signaling pathway','P','Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway.','2013-10-27','NSRP'),(1544,2158,'osteoclast proliferation','P','The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.','2013-10-27','NSRP'),(1545,2159,'desmosome assembly','P','A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.','2013-10-27','NSRP'),(1546,2160,'desmosome maintenance','P','The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.','2013-10-27','NSRP'),(1547,2161,'aminoacyl-tRNA editing activity','F','The hydrolysis of an incorrectly aminoacylated tRNA.','2013-10-27','NSRP'),(1548,2162,'dystroglycan binding','F','Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal).','2013-10-27','NSRP'),(1549,2163,'alpha-dystroglycan binding','F','Interacting selectively and non-covalently with alpha-dystroglycan. Alpha-dystroglycan is extracellular protein derived from cleavage of dystroglycan.','2012-03-14','NSRP'),(1550,2164,'larval development','P','The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters.','2013-10-27','NSRP'),(1551,2165,'instar larval or pupal development','P','The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(1552,2166,'beta-dystroglycan binding','F','Interacting selectively and non-covalently with beta-dystroglycan. Beta-dystroglycan is a transmembrane protein derived from cleavage of dystroglycan.','2012-03-14','NSRP'),(1553,2167,'VRK3/VHR/ERK complex','C','A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway.','2013-10-27','NSRP'),(1554,2168,'instar larval development','P','The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(1555,2169,'3-methylcrotonyl-CoA carboxylase complex, mitochondrial','C','A heterodimeric complex having 3-methylcrotonyl-CoA carboxylase activity. The alpha subunit has a covalently bound biotin essential for the ATP-dependent carboxylation. The beta subunit possess carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA.','2013-10-27','NSRP'),(1556,2170,'high affinity IgA receptor activity','F','Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1557,2171,'low affinity IgA receptor activity','F','Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1558,2172,'high affinity IgM receptor activity','F','Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1559,2173,'low affinity IgM receptor activity','F','Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(1560,2174,'mammary stem cell proliferation','P','The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ.','2013-10-27','NSRP'),(1561,2175,'protein localization to paranode region of axon','P','A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon.','2013-10-27','NSRP'),(1562,2176,'male germ cell proliferation','P','The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(1563,2177,'manchette','C','A conical shaped array of microtubules that completely covers the nucleus of a spermatid, thought to be involved in sperm head elongation.','2013-10-27','NSRP'),(1564,2178,'palmitoyltransferase complex','C','A protein complex with palmitoyltransferase activity.','2013-10-27','NSRP'),(1565,2179,'homodimeric serine palmitoyltransferase complex','C','A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine.','2013-10-27','NSRP'),(1566,2180,'5-lipoxygenase complex','C','An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity.','2013-10-27','NSRP'),(1567,2181,'cytoplasmic translation','P','The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.','2013-10-27','NSRP'),(1568,2182,'cytoplasmic translational elongation','P','The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.','2013-10-27','NSRP'),(1569,2183,'cytoplasmic translational initiation','P','The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.','2013-10-27','NSRP'),(1570,2184,'cytoplasmic translational termination','P','The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon.','2013-10-27','NSRP'),(1571,2185,'creatine kinase complex','C','A protein complex having creatine kinase activity.','2013-10-27','NSRP'),(1572,2186,'cytosolic creatine kinase complex','C','A dimeric protein complex having creatine kinase activity.','2013-10-27','NSRP'),(1573,2187,'mitochondrial creatine kinase complex','C','An octomeric protein complex having creatine kinase activity.','2013-10-27','NSRP'),(1574,2188,'translation reinitiation','P','A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon.','2013-10-27','NSRP'),(1575,2189,'ribose phosphate diphosphokinase complex','C','A protein complex having ribose phosphate diphosphokinase activity.','2013-10-27','NSRP'),(1576,2190,'cap-independent translational initiation','P','The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5\' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.','2013-10-27','NSRP'),(1577,2191,'cap-dependent translational initiation','P','The process where the \"Cap structure\" (composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins) located at the 5\' end of an mRNA molecule, which serves as a \"molecular tag\" that marks the spot where the 40S ribosomal subunit is recruited and will then scan in a 5\' to 3\' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.','2013-10-27','NSRP'),(1578,2192,'IRES-dependent translational initiation','P','The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation.','2013-10-27','NSRP'),(1579,2193,'MAML1-RBP-Jkappa- ICN1 complex','C','A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling.','2013-10-27','NSRP'),(1580,2194,'hepatocyte cell migration','P','The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes.','2013-10-27','NSRP'),(1581,2200,'somatic diversification of immune receptors','P','The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences.','2013-10-27','NSRP'),(1582,2201,'somatic diversification of DSCAM-based immune receptors','P','The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects.','2013-10-27','NSRP'),(1583,2202,'somatic diversification of variable lymphocyte receptors of jawless fish','P','The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish.','2013-10-27','NSRP'),(1584,2203,'proteolysis by cytosolic proteases associated with antigen processing and presentation','P','The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation.','2013-10-27','NSRP'),(1585,2204,'somatic recombination of immunoglobulin genes involved in immune response','P','The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response.','2013-10-27','NSRP'),(1586,2205,'somatic hypermutation of immunoglobulin genes involved in immune response','P','Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response.','2013-10-27','NSRP'),(1587,2206,'gene conversion of immunoglobulin genes','P','The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion.','2013-10-27','NSRP'),(1588,2207,'gene conversion of immunoglobulin genes involved in immune response','P','The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response.','2013-10-27','NSRP'),(1589,2208,'somatic diversification of immunoglobulins involved in immune response','P','The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response.','2013-10-27','NSRP'),(1590,2209,'behavioral defense response','P','A behavioral response seeking to protect an organism from an a perceived external threat to that organism.','2013-10-27','NSRP'),(1591,2210,'behavioral response to wounding','P','A behavioral response resulting from wounding.','2013-10-27','NSRP'),(1592,2211,'behavioral defense response to insect','P','A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism.','2013-10-27','NSRP'),(1593,2212,'behavioral defense response to nematode','P','A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism.','2013-10-27','NSRP'),(1594,2213,'defense response to insect','P','A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism.','2013-10-27','NSRP'),(1595,2215,'defense response to nematode','P','A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.','2013-10-27','NSRP'),(1596,2218,'activation of innate immune response','P','Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species.','2013-10-27','NSRP'),(1597,2220,'innate immune response activating cell surface receptor signaling pathway','P','Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor.','2013-10-27','NSRP'),(1598,2221,'pattern recognition receptor signaling pathway','P','Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.','2013-10-27','NSRP'),(1599,2222,'stimulatory killer cell immunoglobulin-like receptor signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation.','2013-10-27','NSRP'),(1600,2223,'stimulatory C-type lectin receptor signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation.','2013-10-27','NSRP'),(1601,2224,'toll-like receptor signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.','2013-10-27','NSRP'),(1602,2225,'positive regulation of antimicrobial peptide production','P','Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production.','2013-10-27','NSRP'),(1603,2227,'innate immune response in mucosa','P','Any process of the innate immune response that takes place in the mucosal tissues.','2013-10-27','NSRP'),(1604,2228,'natural killer cell mediated immunity','P','The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines.','2013-10-27','NSRP'),(1605,2229,'defense response to oomycetes','P','Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism.','2013-10-27','NSRP'),(1606,2230,'positive regulation of defense response to virus by host','P','Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.','2013-10-27','NSRP'),(1607,2231,'detection of oomycetes','P','The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal.','2013-10-27','NSRP'),(1608,2232,'leukocyte chemotaxis involved in inflammatory response','P','The movement of an immune cell in response to an external stimulus contributing to an inflammatory response.','2013-10-27','NSRP'),(1609,2233,'leukocyte chemotaxis involved in immune response','P','The movement of an immune cell in response to an external stimulus a part of an immune response.','2013-10-27','NSRP'),(1610,2234,'detection of endoplasmic reticulum overloading','P','The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal.','2013-10-27','NSRP'),(1611,2235,'detection of unfolded protein','P','The series of events in which an unfolded protein stimulus is received and converted into a molecular signal.','2013-10-27','NSRP'),(1612,2236,'detection of misfolded protein','P','The series of events in which a misfolded protein stimulus is received and converted into a molecular signal.','2013-10-27','NSRP'),(1613,2237,'response to molecule of bacterial origin','P','Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.','2013-10-27','NSRP'),(1614,2238,'response to molecule of fungal origin','P','Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide.','2013-10-27','NSRP'),(1615,2239,'response to oomycetes','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes.','2013-10-27','NSRP'),(1616,2240,'response to molecule of oomycetes origin','P','Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin.','2013-10-27','NSRP'),(1617,2241,'response to parasitic plant','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant.','2013-10-27','NSRP'),(1618,2242,'defense response to parasitic plant','P','Reactions triggered in response to the presence of a parasitic plant that act to protect an organism.','2013-10-27','NSRP'),(1619,2243,'detection of parasitic plant','P','The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal.','2013-10-27','NSRP'),(1620,2244,'hematopoietic progenitor cell differentiation','P','The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.','2013-10-27','NSRP'),(1621,2246,'wound healing involved in inflammatory response','P','The series of events that restore integrity to damaged tissue that contribute to an inflammatory response.','2013-10-27','NSRP'),(1622,2247,'clearance of damaged tissue involved in inflammatory response wound healing','P','The series of events leading to removal of necrotic debris that contribute to an inflammatory response.','2013-10-27','NSRP'),(1623,2248,'connective tissue replacement involved in inflammatory response wound healing','P','The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response.','2013-10-27','NSRP'),(1624,2249,'lymphocyte anergy','P','Any process contributing to lymphocyte anergy, a state of functional inactivation.','2013-10-27','NSRP'),(1625,2250,'adaptive immune response','P','An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).','2013-10-27','NSRP'),(1626,2251,'organ or tissue specific immune response','P','An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues.','2013-10-27','NSRP'),(1627,2252,'immune effector process','P','Any process of the immune system that can potentially contribute to an immune response.','2013-10-27','NSRP'),(1628,2253,'activation of immune response','P','Any process that initiates an immune response.','2013-10-27','NSRP'),(1629,2254,'kinin cascade','P','A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.','2013-10-27','NSRP'),(1630,2255,'tissue kallikrein-kinin cascade','P','A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.','2013-10-27','NSRP'),(1631,2256,'regulation of kinin cascade','P','Any process that modulates the frequency, rate, or extent of the kinin cascade.','2013-10-27','NSRP'),(1632,2257,'negative regulation of kinin cascade','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade.','2013-10-27','NSRP'),(1633,2258,'positive regulation of kinin cascade','P','Any process that activates or increases the frequency, rate, or extent of the kinin cascade.','2013-10-27','NSRP'),(1634,2259,'endothelial cell activation within high endothelial venule involved in immune response','P','A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1635,2260,'lymphocyte homeostasis','P','The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.','2013-10-27','NSRP'),(1636,2261,'mucosal lymphocyte homeostasis','P','The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus.','2013-10-27','NSRP'),(1637,2262,'myeloid cell homeostasis','P','The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.','2013-10-27','NSRP'),(1638,2263,'cell activation involved in immune response','P','A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1639,2264,'endothelial cell activation involved in immune response','P','A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1640,2265,'astrocyte activation involved in immune response','P','A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1641,2266,'follicular dendritic cell activation','P','A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.','2013-10-27','NSRP'),(1642,2267,'follicular dendritic cell activation involved in immune response','P','A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1643,2268,'follicular dendritic cell differentiation','P','The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell.','2013-10-27','NSRP'),(1644,2269,'leukocyte activation involved in inflammatory response','P','A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response.','2013-10-27','NSRP'),(1645,2270,'plasmacytoid dendritic cell activation','P','A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand.','2013-10-27','NSRP'),(1646,2271,'plasmacytoid dendritic cell activation involved in immune response','P','A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1647,2272,'plasmacytoid dendritic cell differentiation involved in immune response','P','The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response.','2013-10-27','NSRP'),(1648,2273,'plasmacytoid dendritic cell differentiation','P','The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell.','2013-10-27','NSRP'),(1649,2274,'myeloid leukocyte activation','P','A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand.','2013-10-27','NSRP'),(1650,2275,'myeloid cell activation involved in immune response','P','A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1651,2276,'basophil activation involved in immune response','P','A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1652,2277,'myeloid dendritic cell activation involved in immune response','P','The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1653,2278,'eosinophil activation involved in immune response','P','The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1654,2279,'mast cell activation involved in immune response','P','The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1655,2280,'monocyte activation involved in immune response','P','The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1656,2281,'macrophage activation involved in immune response','P','A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1657,2282,'microglial cell activation involved in immune response','P','The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1658,2283,'neutrophil activation involved in immune response','P','The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1659,2284,'myeloid dendritic cell differentiation involved in immune response','P','The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.','2013-10-27','NSRP'),(1660,2285,'lymphocyte activation involved in immune response','P','A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1661,2286,'T cell activation involved in immune response','P','The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1662,2287,'alpha-beta T cell activation involved in immune response','P','The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1663,2288,'NK T cell activation involved in immune response','P','The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1664,2289,'NK T cell proliferation involved in immune response','P','The expansion of a NK T cell population by cell division as part of an immune response.','2013-10-27','NSRP'),(1665,2290,'gamma-delta T cell activation involved in immune response','P','The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1666,2291,'T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell','P','The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1667,2292,'T cell differentiation involved in immune response','P','The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.','2013-10-27','NSRP'),(1668,2293,'alpha-beta T cell differentiation involved in immune response','P','The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.','2013-10-27','NSRP'),(1669,2294,'CD4-positive, alpha-beta T cell differentiation involved in immune response','P','The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.','2013-10-27','NSRP'),(1670,2295,'T-helper cell lineage commitment','P','The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes.','2013-10-27','NSRP'),(1671,2296,'T-helper 1 cell lineage commitment','P','The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis.','2013-10-27','NSRP'),(1672,2297,'T-helper 2 cell lineage commitment','P','The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy.','2013-10-27','NSRP'),(1673,2298,'CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response','P','The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response.','2013-10-27','NSRP'),(1674,2299,'alpha-beta intraepithelial T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.','2013-10-27','NSRP'),(1675,2300,'CD8-positive, alpha-beta intraepithelial T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.','2013-10-27','NSRP'),(1676,2301,'CD4-positive, alpha-beta intraepithelial T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.','2013-10-27','NSRP'),(1677,2302,'CD8-positive, alpha-beta T cell differentiation involved in immune response','P','The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.','2013-10-27','NSRP'),(1678,2303,'gamma-delta T cell differentiation involved in immune response','P','The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.','2013-10-27','NSRP'),(1679,2304,'gamma-delta intraepithelial T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.','2013-10-27','NSRP'),(1680,2305,'CD8-positive, gamma-delta intraepithelial T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.','2013-10-27','NSRP'),(1681,2306,'CD4-positive gamma-delta intraepithelial T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways.','2013-10-27','NSRP'),(1682,2307,'CD8-positive, alpha-beta regulatory T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell.','2013-10-27','NSRP'),(1683,2308,'CD8-positive, alpha-beta cytotoxic T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell.','2013-10-27','NSRP'),(1684,2309,'T cell proliferation involved in immune response','P','The expansion of a T cell population by cell division as part of an immune response.','2013-10-27','NSRP'),(1685,2310,'alpha-beta T cell proliferation involved in immune response','P','The expansion of an alpha-beta T cell population by cell division as part of an immune response.','2013-10-27','NSRP'),(1686,2311,'gamma-delta T cell proliferation involved in immune response','P','The expansion of a gamma-delta T cell population by cell division as part of an immune response.','2013-10-27','NSRP'),(1687,2312,'B cell activation involved in immune response','P','The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.','2013-10-27','NSRP'),(1688,2313,'mature B cell differentiation involved in immune response','P','The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.','2013-10-27','NSRP'),(1689,2314,'germinal center B cell differentiation','P','The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).','2013-10-27','NSRP'),(1690,2315,'marginal zone B cell differentiation','P','The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL).','2013-10-27','NSRP'),(1691,2316,'follicular B cell differentiation','P','The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.','2013-10-27','NSRP'),(1692,2317,'plasma cell differentiation','P','The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.','2013-10-27','NSRP'),(1693,2318,'myeloid progenitor cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.','2013-10-27','NSRP'),(1694,2319,'memory B cell differentiation','P','The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.','2013-10-27','NSRP'),(1695,2320,'lymphoid progenitor cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.','2013-10-27','NSRP'),(1696,2321,'natural killer cell progenitor differentiation','P','The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor.','2013-10-27','NSRP'),(1697,2322,'B cell proliferation involved in immune response','P','The expansion of a B cell population by cell division following B cell activation during an immune response.','2013-10-27','NSRP'),(1698,2323,'natural killer cell activation involved in immune response','P','The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1699,2324,'natural killer cell proliferation involved in immune response','P','The expansion of a natural killer cell population by cell division as part of an immune response.','2013-10-27','NSRP'),(1700,2325,'natural killer cell differentiation involved in immune response','P','The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response.','2013-10-27','NSRP'),(1701,2326,'B cell lineage commitment','P','The process in which a lymphoid progenitor cell becomes committed to become any type of B cell.','2013-10-27','NSRP'),(1702,2327,'immature B cell differentiation','P','The process in which a precursor cell type acquires the specialized features of an immature B cell.','2013-10-27','NSRP'),(1703,2328,'pro-B cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.','2013-10-27','NSRP'),(1704,2329,'pre-B cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.','2013-10-27','NSRP'),(1705,2330,'pre-B cell receptor expression','P','The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface.','2013-10-27','NSRP'),(1706,2331,'pre-B cell allelic exclusion','P','Expression of a single heavy chain allele during pre-B cell differentiation.','2013-10-27','NSRP'),(1707,2332,'transitional stage B cell differentiation','P','The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent.','2013-10-27','NSRP'),(1708,2333,'transitional one stage B cell differentiation','P','The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21.','2013-10-27','NSRP'),(1709,2334,'transitional two stage B cell differentiation','P','The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21.','2013-10-27','NSRP'),(1710,2335,'mature B cell differentiation','P','The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.','2013-10-27','NSRP'),(1711,2336,'B-1 B cell lineage commitment','P','The process in which an immature B cell becomes committed to become a B-1 B cell.','2013-10-27','NSRP'),(1712,2337,'B-1a B cell differentiation','P','The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.','2013-10-27','NSRP'),(1713,2338,'B-1b B cell differentiation','P','The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5.','2013-10-27','NSRP'),(1714,2339,'B cell selection','P','The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.','2013-10-27','NSRP'),(1715,2340,'central B cell selection','P','Any B cell selection process that occurs in the bone marrow.','2013-10-27','NSRP'),(1716,2341,'central B cell anergy','P','Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow.','2013-10-27','NSRP'),(1717,2342,'central B cell deletion','P','The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection.','2013-10-27','NSRP'),(1718,2343,'peripheral B cell selection','P','Any B cell selection process that occurs in the periphery.','2013-10-27','NSRP'),(1719,2344,'B cell affinity maturation','P','The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.','2013-10-27','NSRP'),(1720,2345,'peripheral B cell receptor editing','P','The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation.','2013-10-27','NSRP'),(1721,2346,'B cell positive selection','P','Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor.','2013-10-27','NSRP'),(1722,2347,'response to tumor cell','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell.','2013-10-27','NSRP'),(1723,2348,'central B cell positive selection','P','Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.','2013-10-27','NSRP'),(1724,2349,'histamine production involved in inflammatory response','P','The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1725,2350,'peripheral B cell positive selection','P','Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors.','2013-10-27','NSRP'),(1726,2351,'serotonin production involved in inflammatory response','P','The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1727,2352,'B cell negative selection','P','Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.','2013-10-27','NSRP'),(1728,2353,'plasma kallikrein-kinin cascade','P','A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.','2013-10-27','NSRP'),(1729,2354,'central B cell negative selection','P','Any process leading to negative selection of B cells in the bone marrow.','2013-10-27','NSRP'),(1730,2355,'detection of tumor cell','P','The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal.','2013-10-27','NSRP'),(1731,2356,'peripheral B cell negative selection','P','Any process leading to negative selection of B cells in the periphery.','2013-10-27','NSRP'),(1732,2357,'defense response to tumor cell','P','Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism.','2013-10-27','NSRP'),(1733,2358,'B cell homeostatic proliferation','P','The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.','2013-10-27','NSRP'),(1734,2359,'B-1 B cell proliferation','P','The expansion of a B-1 B cell by cell division. Follows B cell activation.','2013-10-27','NSRP'),(1735,2360,'T cell lineage commitment','P','The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell.','2013-10-27','NSRP'),(1736,2361,'CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell.','2013-10-27','NSRP'),(1737,2362,'CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment','P','The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell.','2013-10-27','NSRP'),(1738,2363,'alpha-beta T cell lineage commitment','P','The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell.','2013-10-27','NSRP'),(1739,2364,'NK T cell lineage commitment','P','The process in which a pro-T cell becomes committed to becoming an NK T cell.','2013-10-27','NSRP'),(1740,2365,'gamma-delta T cell lineage commitment','P','The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell.','2013-10-27','NSRP'),(1741,2366,'leukocyte activation involved in immune response','P','A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.','2013-10-27','NSRP'),(1742,2367,'cytokine production involved in immune response','P','The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1743,2368,'B cell cytokine production','P','Any process that contributes to cytokine production by a B cell.','2013-10-27','NSRP'),(1744,2369,'T cell cytokine production','P','Any process that contributes to cytokine production by a T cell.','2013-10-27','NSRP'),(1745,2370,'natural killer cell cytokine production','P','Any process that contributes to cytokine production by a natural killer cell.','2013-10-27','NSRP'),(1746,2371,'dendritic cell cytokine production','P','Any process that contributes to cytokine production by a dendritic cell.','2013-10-27','NSRP'),(1747,2372,'myeloid dendritic cell cytokine production','P','Any process that contributes to cytokine production by a myeloid dendritic cell.','2013-10-27','NSRP'),(1748,2373,'plasmacytoid dendritic cell cytokine production','P','Any process that contributes to cytokine production by a plasmacytoid dendritic cell.','2013-10-27','NSRP'),(1749,2374,'cytokine secretion involved in immune response','P','The regulated release of cytokines from a cell that contributes to an immune response.','2013-10-27','NSRP'),(1750,2375,'cytokine biosynthetic process involved in immune response','P','The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response.','2013-10-27','NSRP'),(1751,2376,'immune system process','P','Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.','2013-10-27','NSRP'),(1752,2377,'immunoglobulin production','P','The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1753,2378,'immunoglobulin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of immunoglobulin.','2013-10-27','NSRP'),(1754,2379,'immunoglobulin biosynthetic process involved in immune response','P','The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response.','2013-10-27','NSRP'),(1755,2380,'immunoglobulin secretion involved in immune response','P','The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response.','2013-10-27','NSRP'),(1756,2381,'immunoglobulin production involved in immunoglobulin mediated immune response','P','The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1757,2382,'regulation of tissue kallikrein-kinin cascade','P','Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade.','2013-10-27','NSRP'),(1758,2383,'immune response in brain or nervous system','P','An immune response taking place in the brain or nervous system.','2013-10-27','NSRP'),(1759,2384,'hepatic immune response','P','An immune response taking place in the liver.','2013-10-27','NSRP'),(1760,2385,'mucosal immune response','P','An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.','2013-10-27','NSRP'),(1761,2386,'immune response in mucosal-associated lymphoid tissue','P','Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes.','2013-10-27','NSRP'),(1762,2387,'immune response in gut-associated lymphoid tissue','P','Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer\'s patches, appendix, and solitary lymph nodules.','2013-10-27','NSRP'),(1763,2388,'immune response in Peyer\'s patch','P','Immune response taking place in the Peyer\'s patch, nodular lymphoid structures on the serosal surface of the small intestine.','2013-10-27','NSRP'),(1764,2389,'tolerance induction in Peyer\'s patch','P','Tolerance induction taking place in the Peyer\'s patches.','2013-10-27','NSRP'),(1765,2390,'platelet activating factor production','P','The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1766,2391,'platelet activating factor production involved in inflammatory response','P','The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1767,2392,'platelet activating factor secretion','P','The regulated release of platelet activating factor by a cell.','2013-10-27','NSRP'),(1768,2393,'lysosomal enzyme production involved in inflammatory response','P','The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels.','2013-10-27','NSRP'),(1769,2394,'tolerance induction in gut-associated lymphoid tissue','P','Tolerance induction taking place in the gut-associated lymphoid tissue (GALT).','2013-10-27','NSRP'),(1770,2395,'immune response in nasopharyngeal-associated lymphoid tissue','P','An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids.','2013-10-27','NSRP'),(1771,2396,'MHC protein complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.','2013-10-27','NSRP'),(1772,2397,'MHC class I protein complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(1773,2398,'MHC class Ib protein complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules.','2013-10-27','NSRP'),(1774,2399,'MHC class II protein complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.','2013-10-27','NSRP'),(1775,2400,'tolerance induction in nasopharyngeal-associated lymphoid tissue','P','Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT).','2013-10-27','NSRP'),(1776,2401,'tolerance induction in mucosal-associated lymphoid tissue','P','Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT).','2013-10-27','NSRP'),(1777,2402,'B cell tolerance induction in mucosal-associated lymphoid tissue','P','Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells.','2013-10-27','NSRP'),(1778,2403,'T cell tolerance induction in mucosal-associated lymphoid tissue','P','Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells.','2013-10-27','NSRP'),(1779,2404,'antigen sampling in mucosal-associated lymphoid tissue','P','The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue.','2013-10-27','NSRP'),(1780,2405,'antigen sampling by dendritic cells in mucosal-associated lymphoid tissue','P','The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue.','2013-10-27','NSRP'),(1781,2406,'antigen sampling by M cells in mucosal-associated lymphoid tissue','P','The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue.','2013-10-27','NSRP'),(1782,2407,'dendritic cell chemotaxis','P','The movement of a dendritic cell in response to an external stimulus.','2013-10-27','NSRP'),(1783,2408,'myeloid dendritic cell chemotaxis','P','The movement of a myeloid dendritic cell in response to an external stimulus.','2013-10-27','NSRP'),(1784,2409,'Langerhans cell chemotaxis','P','The movement of a Langerhans cell in response to an external stimulus.','2013-10-27','NSRP'),(1785,2410,'plasmacytoid dendritic cell chemotaxis','P','The movement of a plasmacytoid dendritic cell in response to an external stimulus.','2013-10-27','NSRP'),(1786,2411,'T cell tolerance induction to tumor cell','P','A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor.','2013-10-27','NSRP'),(1787,2412,'antigen transcytosis by M cells in mucosal-associated lymphoid tissue','P','The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT.','2013-10-27','NSRP'),(1788,2413,'tolerance induction to tumor cell','P','A process of tolerance induction which leads to immunological tolerance of a tumor.','2013-10-27','NSRP'),(1789,2414,'immunoglobulin transcytosis in epithelial cells','P','The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.','2013-10-27','NSRP'),(1790,2415,'immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor','P','The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa.','2013-10-27','NSRP'),(1791,2416,'IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor','P','The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals.','2013-10-27','NSRP'),(1792,2417,'B cell antigen processing and presentation mediated by B cell receptor uptake of antigen','P','B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor.','2013-10-27','NSRP'),(1793,2418,'immune response to tumor cell','P','An immune system process that functions in the response of an organism to a tumor cell.','2013-10-27','NSRP'),(1794,2419,'T cell mediated cytotoxicity directed against tumor cell target','P','The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.','2013-10-27','NSRP'),(1795,2420,'natural killer cell mediated cytotoxicity directed against tumor cell target','P','The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.','2013-10-27','NSRP'),(1796,2421,'B cell antigen processing and presentation following pinocytosis','P','B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.','2013-10-27','NSRP'),(1797,2422,'immune response in urogenital tract','P','An immune response taking place in the urogenital tract. The urogenital tract.','2013-10-27','NSRP'),(1798,2423,'natural killer cell mediated immune response to tumor cell','P','An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell.','2013-10-27','NSRP'),(1799,2424,'T cell mediated immune response to tumor cell','P','An immune response mediated by a T cell triggered in response to the presence of a tumor cell.','2013-10-27','NSRP'),(1800,2425,'tolerance induction in urogenital tract','P','Tolerance induction taking place in the urogenital tract.','2013-10-27','NSRP'),(1801,2426,'immunoglobulin production in mucosal tissue','P','The synthesis and release of immunoglobulin in the mucosal tissue.','2013-10-27','NSRP'),(1802,2427,'mucosal tolerance induction','P','Tolerance induction taking place in the mucosal tissues.','2013-10-27','NSRP'),(1803,2428,'antigen processing and presentation of peptide antigen via MHC class Ib','P','The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family.','2013-10-27','NSRP'),(1804,2429,'immune response-activating cell surface receptor signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response.','2013-10-27','NSRP'),(1805,2430,'complement receptor mediated signaling pathway','P','A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.','2013-10-27','NSRP'),(1806,2431,'Fc receptor mediated stimulatory signaling pathway','P','A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.','2013-10-27','NSRP'),(1807,2432,'granuloma formation','P','The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.','2013-10-27','NSRP'),(1808,2433,'immune response-regulating cell surface receptor signaling pathway involved in phagocytosis','P','An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.','2013-10-27','NSRP'),(1809,2434,'immune complex clearance','P','A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution.','2013-10-27','NSRP'),(1810,2435,'immune complex clearance by erythrocytes','P','The process of immune complex clearance by erythrocytes.','2013-10-27','NSRP'),(1811,2436,'immune complex clearance by monocytes and macrophages','P','The process of immune complex clearance by monocytes or macrophages.','2013-10-27','NSRP'),(1812,2437,'inflammatory response to antigenic stimulus','P','An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.','2013-10-27','NSRP'),(1813,2438,'acute inflammatory response to antigenic stimulus','P','An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.','2013-10-27','NSRP'),(1814,2439,'chronic inflammatory response to antigenic stimulus','P','A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual.','2013-10-27','NSRP'),(1815,2440,'production of molecular mediator of immune response','P','The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1816,2441,'histamine secretion involved in inflammatory response','P','The regulated release of histamine by a cell as part of an inflammatory response.','2013-10-27','NSRP'),(1817,2442,'serotonin secretion involved in inflammatory response','P','The regulated release of serotonin by a cell as part of an inflammatory response.','2013-10-27','NSRP'),(1818,2443,'leukocyte mediated immunity','P','Any process involved in the carrying out of an immune response by a leukocyte.','2013-10-27','NSRP'),(1819,2444,'myeloid leukocyte mediated immunity','P','Any process involved in the carrying out of an immune response by a myeloid leukocyte.','2013-10-27','NSRP'),(1820,2445,'type II hypersensitivity','P','An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.','2013-10-27','NSRP'),(1821,2446,'neutrophil mediated immunity','P','Any process involved in the carrying out of an immune response by a neutrophil.','2013-10-27','NSRP'),(1822,2447,'eosinophil mediated immunity','P','Any process involved in the carrying out of an immune response by an eosinophil.','2013-10-27','NSRP'),(1823,2448,'mast cell mediated immunity','P','Any process involved in the carrying out of an immune response by a mast cell.','2013-10-27','NSRP'),(1824,2449,'lymphocyte mediated immunity','P','Any process involved in the carrying out of an immune response by a lymphocyte.','2013-10-27','NSRP'),(1825,2450,'B cell antigen processing and presentation','P','The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(1826,2451,'peripheral B cell tolerance induction','P','Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue.','2013-10-27','NSRP'),(1827,2452,'B cell receptor editing','P','The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor.','2013-10-27','NSRP'),(1828,2453,'peripheral B cell anergy','P','Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells.','2013-10-27','NSRP'),(1829,2454,'peripheral B cell deletion','P','The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection.','2013-10-27','NSRP'),(1830,2455,'humoral immune response mediated by circulating immunoglobulin','P','An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(1831,2456,'T cell mediated immunity','P','Any process involved in the carrying out of an immune response by a T cell.','2013-10-27','NSRP'),(1832,2457,'T cell antigen processing and presentation','P','The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(1833,2458,'peripheral T cell tolerance induction','P','Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus.','2013-10-27','NSRP'),(1834,2459,'adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains','P','An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae).','2013-10-27','NSRP'),(1835,2460,'adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains','P','An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus.','2013-10-27','NSRP'),(1836,2461,'tolerance induction dependent upon immune response','P','Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation.','2013-10-27','NSRP'),(1837,2462,'tolerance induction to nonself antigen','P','Tolerance induction in response to nonself antigens.','2013-10-27','NSRP'),(1838,2463,'central tolerance induction to nonself antigen','P','Tolerance induction to nonself antigens in the central lymphoid organs.','2013-10-27','NSRP'),(1839,2464,'peripheral tolerance induction to nonself antigen','P','Tolerance induction to nonself antigens in the periphery.','2013-10-27','NSRP'),(1840,2465,'peripheral tolerance induction','P','Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.','2013-10-27','NSRP'),(1841,2466,'peripheral tolerance induction to self antigen','P','Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues.','2013-10-27','NSRP'),(1842,2467,'germinal center formation','P','The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.','2013-10-27','NSRP'),(1843,2468,'dendritic cell antigen processing and presentation','P','The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(1844,2469,'myeloid dendritic cell antigen processing and presentation','P','The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(1845,2470,'plasmacytoid dendritic cell antigen processing and presentation','P','The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(1846,2471,'monocyte antigen processing and presentation','P','The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(1847,2472,'macrophage antigen processing and presentation','P','The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.','2013-10-27','NSRP'),(1848,2473,'non-professional antigen presenting cell antigen processing and presentation','P','The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils.','2013-10-27','NSRP'),(1849,2474,'antigen processing and presentation of peptide antigen via MHC class I','P','The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(1850,2475,'antigen processing and presentation via MHC class Ib','P','The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.','2013-10-27','NSRP'),(1851,2476,'antigen processing and presentation of endogenous peptide antigen via MHC class Ib','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.','2013-10-27','NSRP'),(1852,2477,'antigen processing and presentation of exogenous peptide antigen via MHC class Ib','P','The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.','2013-10-27','NSRP'),(1853,2478,'antigen processing and presentation of exogenous peptide antigen','P','The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell.','2013-10-27','NSRP'),(1854,2479,'antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent','P','The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(1855,2480,'antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent','P','The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(1856,2481,'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent','P','The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.','2013-10-27','NSRP'),(1857,2482,'antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent','P','The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.','2013-10-27','NSRP'),(1858,2483,'antigen processing and presentation of endogenous peptide antigen','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell.','2013-10-27','NSRP'),(1859,2484,'antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(1860,2485,'antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(1861,2486,'antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(1862,2487,'antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(1863,2488,'antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.','2013-10-27','NSRP'),(1864,2489,'antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.','2013-10-27','NSRP'),(1865,2490,'antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.','2013-10-27','NSRP'),(1866,2491,'antigen processing and presentation of endogenous peptide antigen via MHC class II','P','The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.','2013-10-27','NSRP'),(1867,2492,'peptide antigen assembly with MHC class Ib protein complex','P','The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family.','2013-10-27','NSRP'),(1868,2493,'lipid antigen assembly with MHC class Ib protein complex','P','The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family.','2013-10-27','NSRP'),(1869,2494,'lipid antigen transport','P','The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(1870,2495,'antigen processing and presentation of peptide antigen via MHC class II','P','The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein.','2013-10-27','NSRP'),(1871,2496,'proteolysis associated with antigen processing and presentation','P','The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation.','2013-10-27','NSRP'),(1872,2497,'proteasomal proteolysis associated with antigen processing and presentation','P','The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation.','2013-10-27','NSRP'),(1873,2498,'proteolysis within endoplasmic reticulum associated with antigen processing and presentation','P','The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation.','2013-10-27','NSRP'),(1874,2499,'proteolysis within endosome associated with antigen processing and presentation','P','The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation.','2013-10-27','NSRP'),(1875,2500,'proteolysis within lysosome associated with antigen processing and presentation','P','The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation.','2013-10-27','NSRP'),(1876,2501,'peptide antigen assembly with MHC protein complex','P','The binding of a peptide to the antigen binding groove of an MHC protein complex.','2013-10-27','NSRP'),(1877,2502,'peptide antigen assembly with MHC class I protein complex','P','The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(1878,2503,'peptide antigen assembly with MHC class II protein complex','P','The binding of a peptide to the antigen binding groove of an MHC class II protein complex.','2013-10-27','NSRP'),(1879,2504,'antigen processing and presentation of peptide or polysaccharide antigen via MHC class II','P','The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex.','2013-10-27','NSRP'),(1880,2505,'antigen processing and presentation of polysaccharide antigen via MHC class II','P','The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex.','2013-10-27','NSRP'),(1881,2506,'polysaccharide assembly with MHC class II protein complex','P','The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex.','2013-10-27','NSRP'),(1882,2507,'tolerance induction','P','A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it.','2013-10-27','NSRP'),(1883,2508,'central tolerance induction','P','Tolerance induction in the central lymphoid organs: the thymus and bone marrow.','2013-10-27','NSRP'),(1884,2509,'central tolerance induction to self antigen','P','Tolerance induction in the central lymphoid organs directed at self antigens.','2013-10-27','NSRP'),(1885,2510,'central B cell tolerance induction','P','Tolerance induction of B cells in the bone marrow.','2013-10-27','NSRP'),(1886,2511,'central B cell receptor editing','P','Receptor editing occurring in B cells in the bone marrow.','2013-10-27','NSRP'),(1887,2512,'central T cell tolerance induction','P','Tolerance induction of T cells in the thymus.','2013-10-27','NSRP'),(1888,2513,'tolerance induction to self antigen','P','Tolerance induction directed at self antigens.','2013-10-27','NSRP'),(1889,2514,'B cell tolerance induction','P','A process involving any mechanism for tolerance induction in B cells.','2013-10-27','NSRP'),(1890,2515,'B cell anergy','P','Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction.','2013-10-27','NSRP'),(1891,2516,'B cell deletion','P','The apoptotic death of B cells which is part of B cell tolerance induction.','2013-10-27','NSRP'),(1892,2517,'T cell tolerance induction','P','A process involving any mechanism for tolerance induction in T cells.','2013-10-27','NSRP'),(1893,2518,'lymphocyte chemotaxis across high endothelial venule','P','The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus.','2013-10-27','NSRP'),(1894,2519,'natural killer cell tolerance induction','P','Tolerance induction of natural killer cells.','2013-10-27','NSRP'),(1895,2520,'immune system development','P','The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.','2013-10-27','NSRP'),(1896,2521,'leukocyte differentiation','P','The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.','2013-10-27','NSRP'),(1897,2522,'leukocyte migration involved in immune response','P','The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response.','2013-10-27','NSRP'),(1898,2523,'leukocyte migration involved in inflammatory response','P','The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response.','2013-10-27','NSRP'),(1899,2524,'hypersensitivity','P','An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.','2013-10-27','NSRP'),(1900,2525,'acute inflammatory response to non-antigenic stimulus','P','An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma.','2013-10-27','NSRP'),(1901,2526,'acute inflammatory response','P','Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.','2013-10-27','NSRP'),(1902,2527,'vasodilation involved in acute inflammatory response','P','An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response.','2013-10-27','NSRP'),(1903,2528,'regulation of vascular permeability involved in acute inflammatory response','P','Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response.','2013-10-27','NSRP'),(1904,2529,'regulation of plasma kallikrein-kinin cascade','P','Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade.','2013-10-27','NSRP'),(1905,2530,'regulation of systemic arterial blood pressure involved in acute-phase response','P','Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein.','2013-10-27','NSRP'),(1906,2531,'regulation of heart contraction involved in acute-phase response','P','Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein.','2013-10-27','NSRP'),(1907,2532,'production of molecular mediator involved in inflammatory response','P','The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1908,2533,'lysosomal enzyme secretion involved in inflammatory response','P','The regulated release of lysosomal enzymes by a cell as part of an inflammatory response.','2013-10-27','NSRP'),(1909,2534,'cytokine production involved in inflammatory response','P','The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1910,2535,'platelet activating factor secretion involved in inflammatory response','P','The regulated release of platelet activating factor by a cell as part of an inflammatory response.','2013-10-27','NSRP'),(1911,2536,'respiratory burst involved in inflammatory response','P','A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.','2013-10-27','NSRP'),(1912,2537,'nitric oxide production involved in inflammatory response','P','The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1913,2538,'arachidonic acid metabolite production involved in inflammatory response','P','The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels.','2013-10-27','NSRP'),(1914,2539,'prostaglandin production involved in inflammatory response','P','The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1915,2540,'leukotriene production involved in inflammatory response','P','The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(1916,2541,'activation of plasma proteins involved in acute inflammatory response','P','Any process activating plasma proteins by proteolysis as part of an acute inflammatory response.','2013-10-27','NSRP'),(1917,2542,'Factor XII activation','P','Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.','2013-10-27','NSRP'),(1918,2543,'activation of blood coagulation via clotting cascade','P','Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot.','2013-10-27','NSRP'),(1919,2544,'chronic inflammatory response','P','Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.','2013-10-27','NSRP'),(1920,2545,'chronic inflammatory response to non-antigenic stimulus','P','A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma.','2013-10-27','NSRP'),(1921,2546,'negative regulation of tissue kallikrein-kinin cascade','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade.','2013-10-27','NSRP'),(1922,2547,'positive regulation of tissue kallikrein-kinin cascade','P','Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade.','2013-10-27','NSRP'),(1923,2548,'monocyte chemotaxis','P','The movement of a monocyte in response to an external stimulus.','2013-10-27','NSRP'),(1924,2549,'negative regulation of plasma kallikrein-kinin cascade','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade.','2013-10-27','NSRP'),(1925,2550,'positive regulation of plasma kallikrein-kinin cascade','P','Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade.','2013-10-27','NSRP'),(1926,2551,'mast cell chemotaxis','P','The movement of a mast cell in response to an external stimulus.','2013-10-27','NSRP'),(1927,2552,'serotonin secretion by mast cell','P','The regulated release of serotonin by a mast cell or group of mast cells.','2013-10-27','NSRP'),(1928,2553,'histamine secretion by mast cell','P','The regulated release of histamine by a mast cell or group of mast cells.','2013-10-27','NSRP'),(1929,2554,'serotonin secretion by platelet','P','The regulated release of serotonin by a platelet or group of platelets.','2013-10-27','NSRP'),(1930,2555,'histamine secretion by platelet','P','The regulated release of histamine by a platelet or group of platelets.','2013-10-27','NSRP'),(1931,2556,'serotonin secretion by basophil','P','The regulated release of serotonin by a basophil or group of basophils.','2013-10-27','NSRP'),(1932,2557,'histamine secretion by basophil','P','The regulated release of histamine by a basophil or group of basophils.','2013-10-27','NSRP'),(1933,2558,'type I hypersensitivity mediated by mast cells','P','An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.','2013-10-27','NSRP'),(1934,2559,'type I hypersensitivity mediated by basophils','P','An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.','2013-10-27','NSRP'),(1935,2560,'basophil mediated immunity','P','Any process involved in the carrying out of an immune response by a basophil.','2013-10-27','NSRP'),(1936,2561,'basophil degranulation','P','The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil.','2013-10-27','NSRP'),(1937,2562,'somatic diversification of immune receptors via germline recombination within a single locus','P','The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus.','2013-10-27','NSRP'),(1938,2563,'somatic diversification of immune receptors via alternate splicing','P','The process in which immune receptor genes are diversified through alternate splicing.','2013-10-27','NSRP'),(1939,2564,'alternate splicing of immunoglobulin genes','P','The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons.','2013-10-27','NSRP'),(1940,2565,'somatic diversification of immune receptors via gene conversion','P','The process in which immune receptor genes are diversified through gene conversion.','2013-10-27','NSRP'),(1941,2566,'somatic diversification of immune receptors via somatic mutation','P','The process in which immune receptor genes are diversified through somatic mutation.','2013-10-27','NSRP'),(1942,2567,'somatic diversification of FREP-based immune receptors','P','The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails.','2013-10-27','NSRP'),(1943,2568,'somatic diversification of T cell receptor genes','P','The somatic process that results in the generation of sequence diversity of T cell receptor genes.','2013-10-27','NSRP'),(1944,2569,'somatic diversification of immune receptors by N region addition','P','The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene.','2013-10-27','NSRP'),(1945,2570,'somatic diversification of immunoglobulin genes by N region addition','P','The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions.','2013-10-27','NSRP'),(1946,2571,'somatic diversification of T cell receptor genes by N region addition','P','The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene.','2013-10-27','NSRP'),(1947,2572,'pro-T cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed.','2013-10-27','NSRP'),(1948,2573,'myeloid leukocyte differentiation','P','The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.','2013-10-27','NSRP'),(1949,2574,'thrombocyte differentiation','P','The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.','2013-10-27','NSRP'),(1950,2575,'basophil chemotaxis','P','The movement of a basophil in response to an external stimulus.','2013-10-27','NSRP'),(1951,2576,'platelet degranulation','P','The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.','2013-10-27','NSRP'),(1952,2577,'regulation of antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of antigen processing and presentation.','2013-10-27','NSRP'),(1953,2578,'negative regulation of antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.','2013-10-27','NSRP'),(1954,2579,'positive regulation of antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation.','2013-10-27','NSRP'),(1955,2580,'regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II','P','Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.','2013-10-27','NSRP'),(1956,2581,'negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.','2013-10-27','NSRP'),(1957,2582,'positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II','P','Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II.','2013-10-27','NSRP'),(1958,2583,'regulation of antigen processing and presentation of peptide antigen','P','Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen.','2013-10-27','NSRP'),(1959,2584,'negative regulation of antigen processing and presentation of peptide antigen','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen.','2013-10-27','NSRP'),(1960,2585,'positive regulation of antigen processing and presentation of peptide antigen','P','Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen.','2013-10-27','NSRP'),(1961,2586,'regulation of antigen processing and presentation of peptide antigen via MHC class II','P','Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.','2013-10-27','NSRP'),(1962,2587,'negative regulation of antigen processing and presentation of peptide antigen via MHC class II','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.','2013-10-27','NSRP'),(1963,2588,'positive regulation of antigen processing and presentation of peptide antigen via MHC class II','P','Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.','2013-10-27','NSRP'),(1964,2589,'regulation of antigen processing and presentation of peptide antigen via MHC class I','P','Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.','2013-10-27','NSRP'),(1965,2590,'negative regulation of antigen processing and presentation of peptide antigen via MHC class I','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.','2013-10-27','NSRP'),(1966,2591,'positive regulation of antigen processing and presentation of peptide antigen via MHC class I','P','Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I.','2013-10-27','NSRP'),(1967,2592,'regulation of antigen processing and presentation via MHC class Ib','P','Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.','2013-10-27','NSRP'),(1968,2593,'negative regulation of antigen processing and presentation via MHC class Ib','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.','2013-10-27','NSRP'),(1969,2594,'positive regulation of antigen processing and presentation via MHC class Ib','P','Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib.','2013-10-27','NSRP'),(1970,2595,'regulation of antigen processing and presentation of peptide antigen via MHC class Ib','P','Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.','2013-10-27','NSRP'),(1971,2596,'negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.','2013-10-27','NSRP'),(1972,2597,'positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib','P','Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib.','2013-10-27','NSRP'),(1973,2598,'regulation of antigen processing and presentation of lipid antigen via MHC class Ib','P','Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.','2013-10-27','NSRP'),(1974,2599,'negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.','2013-10-27','NSRP'),(1975,2600,'positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib','P','Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib.','2013-10-27','NSRP'),(1976,2601,'regulation of antigen processing and presentation of polysaccharide antigen via MHC class II','P','Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.','2013-10-27','NSRP'),(1977,2602,'negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.','2013-10-27','NSRP'),(1978,2603,'positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II','P','Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II.','2013-10-27','NSRP'),(1979,2604,'regulation of dendritic cell antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation.','2013-10-27','NSRP'),(1980,2605,'negative regulation of dendritic cell antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation.','2013-10-27','NSRP'),(1981,2606,'positive regulation of dendritic cell antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation.','2013-10-27','NSRP'),(1982,2607,'regulation of myeloid dendritic cell antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.','2013-10-27','NSRP'),(1983,2608,'negative regulation of myeloid dendritic cell antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.','2013-10-27','NSRP'),(1984,2609,'positive regulation of myeloid dendritic cell antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation.','2013-10-27','NSRP'),(1985,2610,'regulation of plasmacytoid dendritic cell antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.','2013-10-27','NSRP'),(1986,2611,'negative regulation of plasmacytoid dendritic cell antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.','2013-10-27','NSRP'),(1987,2612,'positive regulation of plasmacytoid dendritic cell antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation.','2013-10-27','NSRP'),(1988,2613,'regulation of monocyte antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation.','2013-10-27','NSRP'),(1989,2614,'negative regulation of monocyte antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation.','2013-10-27','NSRP'),(1990,2615,'positive regulation of monocyte antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation.','2013-10-27','NSRP'),(1991,2616,'regulation of macrophage antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation.','2013-10-27','NSRP'),(1992,2617,'negative regulation of macrophage antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation.','2013-10-27','NSRP'),(1993,2618,'positive regulation of macrophage antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation.','2013-10-27','NSRP'),(1994,2619,'regulation of non-professional antigen presenting cell antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.','2013-10-27','NSRP'),(1995,2620,'negative regulation of non-professional antigen presenting cell antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.','2013-10-27','NSRP'),(1996,2621,'positive regulation of non-professional antigen presenting cell antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation.','2013-10-27','NSRP'),(1997,2622,'regulation of B cell antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation.','2013-10-27','NSRP'),(1998,2623,'negative regulation of B cell antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation.','2013-10-27','NSRP'),(1999,2624,'positive regulation of B cell antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation.','2013-10-27','NSRP'),(2000,2625,'regulation of T cell antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation.','2013-10-27','NSRP'),(2001,2626,'negative regulation of T cell antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation.','2013-10-27','NSRP'),(2002,2627,'positive regulation of T cell antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation.','2013-10-27','NSRP'),(2003,2628,'regulation of proteolysis associated with antigen processing and presentation','P','Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.','2013-10-27','NSRP'),(2004,2629,'negative regulation of proteolysis associated with antigen processing and presentation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.','2013-10-27','NSRP'),(2005,2630,'positive regulation of proteolysis associated with antigen processing and presentation','P','Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation.','2013-10-27','NSRP'),(2006,2631,'regulation of granuloma formation','P','Any process that modulates the frequency, rate, or extent of granuloma formation.','2013-10-27','NSRP'),(2007,2632,'negative regulation of granuloma formation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation.','2013-10-27','NSRP'),(2008,2633,'positive regulation of granuloma formation','P','Any process that activates or increases the frequency, rate, or extent of granuloma formation.','2013-10-27','NSRP'),(2009,2634,'regulation of germinal center formation','P','Any process that modulates the frequency, rate, or extent of germinal center formation.','2013-10-27','NSRP'),(2010,2635,'negative regulation of germinal center formation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation.','2013-10-27','NSRP'),(2011,2636,'positive regulation of germinal center formation','P','Any process that activates or increases the frequency, rate, or extent of germinal center formation.','2013-10-27','NSRP'),(2012,2637,'regulation of immunoglobulin production','P','Any process that modulates the frequency, rate, or extent of immunoglobulin production.','2013-10-27','NSRP'),(2013,2638,'negative regulation of immunoglobulin production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production.','2013-10-27','NSRP'),(2014,2639,'positive regulation of immunoglobulin production','P','Any process that activates or increases the frequency, rate, or extent of immunoglobulin production.','2013-10-27','NSRP'),(2015,2640,'regulation of immunoglobulin biosynthetic process','P','Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis.','2013-10-27','NSRP'),(2016,2641,'negative regulation of immunoglobulin biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis.','2013-10-27','NSRP'),(2017,2642,'positive regulation of immunoglobulin biosynthetic process','P','Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis.','2013-10-27','NSRP'),(2018,2643,'regulation of tolerance induction','P','Any process that modulates the frequency, rate, or extent of tolerance induction.','2013-10-27','NSRP'),(2019,2644,'negative regulation of tolerance induction','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction.','2013-10-27','NSRP'),(2020,2645,'positive regulation of tolerance induction','P','Any process that activates or increases the frequency, rate, or extent of tolerance induction.','2013-10-27','NSRP'),(2021,2646,'regulation of central tolerance induction','P','Any process that modulates the frequency, rate, or extent of central tolerance induction.','2013-10-27','NSRP'),(2022,2647,'negative regulation of central tolerance induction','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction.','2013-10-27','NSRP'),(2023,2648,'positive regulation of central tolerance induction','P','Any process that activates or increases the frequency, rate, or extent of central tolerance induction.','2013-10-27','NSRP'),(2024,2649,'regulation of tolerance induction to self antigen','P','Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen.','2013-10-27','NSRP'),(2025,2650,'negative regulation of tolerance induction to self antigen','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen.','2013-10-27','NSRP'),(2026,2651,'positive regulation of tolerance induction to self antigen','P','Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen.','2013-10-27','NSRP'),(2027,2652,'regulation of tolerance induction dependent upon immune response','P','Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response.','2013-10-27','NSRP'),(2028,2653,'negative regulation of tolerance induction dependent upon immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response.','2013-10-27','NSRP'),(2029,2654,'positive regulation of tolerance induction dependent upon immune response','P','Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response.','2013-10-27','NSRP'),(2030,2655,'regulation of tolerance induction to nonself antigen','P','Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen.','2013-10-27','NSRP'),(2031,2656,'negative regulation of tolerance induction to nonself antigen','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen.','2013-10-27','NSRP'),(2032,2657,'positive regulation of tolerance induction to nonself antigen','P','Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen.','2013-10-27','NSRP'),(2033,2658,'regulation of peripheral tolerance induction','P','Any process that modulates the frequency, rate, or extent of peripheral tolerance induction.','2013-10-27','NSRP'),(2034,2659,'negative regulation of peripheral tolerance induction','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction.','2013-10-27','NSRP'),(2035,2660,'positive regulation of peripheral tolerance induction','P','Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction.','2013-10-27','NSRP'),(2036,2661,'regulation of B cell tolerance induction','P','Any process that modulates the frequency, rate, or extent of B cell tolerance induction.','2013-10-27','NSRP'),(2037,2662,'negative regulation of B cell tolerance induction','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction.','2013-10-27','NSRP'),(2038,2663,'positive regulation of B cell tolerance induction','P','Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction.','2013-10-27','NSRP'),(2039,2664,'regulation of T cell tolerance induction','P','Any process that modulates the frequency, rate, or extent of T cell tolerance induction.','2013-10-27','NSRP'),(2040,2665,'negative regulation of T cell tolerance induction','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction.','2013-10-27','NSRP'),(2041,2666,'positive regulation of T cell tolerance induction','P','Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.','2013-10-27','NSRP'),(2042,2667,'regulation of T cell anergy','P','Any process that modulates the frequency, rate, or extent of T cell anergy.','2013-10-27','NSRP'),(2043,2668,'negative regulation of T cell anergy','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy.','2013-10-27','NSRP'),(2044,2669,'positive regulation of T cell anergy','P','Any process that activates or increases the frequency, rate, or extent of T cell anergy.','2013-10-27','NSRP'),(2045,2670,'regulation of B cell anergy','P','Any process that modulates the frequency, rate, or extent of B cell anergy.','2013-10-27','NSRP'),(2046,2671,'negative regulation of B cell anergy','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy.','2013-10-27','NSRP'),(2047,2672,'positive regulation of B cell anergy','P','Any process that activates or increases the frequency, rate, or extent of B cell anergy.','2013-10-27','NSRP'),(2048,2673,'regulation of acute inflammatory response','P','Any process that modulates the frequency, rate, or extent of an acute inflammatory response.','2013-10-27','NSRP'),(2049,2674,'negative regulation of acute inflammatory response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response.','2013-10-27','NSRP'),(2050,2675,'positive regulation of acute inflammatory response','P','Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response.','2013-10-27','NSRP'),(2051,2676,'regulation of chronic inflammatory response','P','Any process that modulates the frequency, rate, or extent of a chronic inflammatory response.','2013-10-27','NSRP'),(2052,2677,'negative regulation of chronic inflammatory response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response.','2013-10-27','NSRP'),(2053,2678,'positive regulation of chronic inflammatory response','P','Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response.','2013-10-27','NSRP'),(2054,2679,'respiratory burst involved in defense response','P','A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals.','2013-10-27','NSRP'),(2055,2680,'pro-T cell lineage commitment','P','The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell.','2013-10-27','NSRP'),(2056,2681,'somatic recombination of T cell receptor gene segments','P','The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments.','2013-10-27','NSRP'),(2057,2682,'regulation of immune system process','P','Any process that modulates the frequency, rate, or extent of an immune system process.','2013-10-27','NSRP'),(2058,2683,'negative regulation of immune system process','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process.','2013-10-27','NSRP'),(2059,2684,'positive regulation of immune system process','P','Any process that activates or increases the frequency, rate, or extent of an immune system process.','2013-10-27','NSRP'),(2060,2685,'regulation of leukocyte migration','P','Any process that modulates the frequency, rate, or extent of leukocyte migration.','2013-10-27','NSRP'),(2061,2686,'negative regulation of leukocyte migration','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration.','2013-10-27','NSRP'),(2062,2687,'positive regulation of leukocyte migration','P','Any process that activates or increases the frequency, rate, or extent of leukocyte migration.','2013-10-27','NSRP'),(2063,2688,'regulation of leukocyte chemotaxis','P','Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis.','2013-10-27','NSRP'),(2064,2689,'negative regulation of leukocyte chemotaxis','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis.','2013-10-27','NSRP'),(2065,2690,'positive regulation of leukocyte chemotaxis','P','Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.','2013-10-27','NSRP'),(2066,2691,'regulation of cellular extravasation','P','Any process that modulates the frequency, rate, or extent of cellular extravasation.','2013-10-27','NSRP'),(2067,2692,'negative regulation of cellular extravasation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation.','2013-10-27','NSRP'),(2068,2693,'positive regulation of cellular extravasation','P','Any process that activates or increases the frequency, rate, or extent of cellular extravasation.','2013-10-27','NSRP'),(2069,2694,'regulation of leukocyte activation','P','Any process that modulates the frequency, rate, or extent of leukocyte activation.','2013-10-27','NSRP'),(2070,2695,'negative regulation of leukocyte activation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.','2013-10-27','NSRP'),(2071,2696,'positive regulation of leukocyte activation','P','Any process that activates or increases the frequency, rate, or extent of leukocyte activation.','2013-10-27','NSRP'),(2072,2697,'regulation of immune effector process','P','Any process that modulates the frequency, rate, or extent of an immune effector process.','2013-10-27','NSRP'),(2073,2698,'negative regulation of immune effector process','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process.','2013-10-27','NSRP'),(2074,2699,'positive regulation of immune effector process','P','Any process that activates or increases the frequency, rate, or extent of an immune effector process.','2013-10-27','NSRP'),(2075,2700,'regulation of production of molecular mediator of immune response','P','Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response.','2013-10-27','NSRP'),(2076,2701,'negative regulation of production of molecular mediator of immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response.','2013-10-27','NSRP'),(2077,2702,'positive regulation of production of molecular mediator of immune response','P','Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.','2013-10-27','NSRP'),(2078,2703,'regulation of leukocyte mediated immunity','P','Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity.','2013-10-27','NSRP'),(2079,2704,'negative regulation of leukocyte mediated immunity','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity.','2013-10-27','NSRP'),(2080,2705,'positive regulation of leukocyte mediated immunity','P','Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity.','2013-10-27','NSRP'),(2081,2706,'regulation of lymphocyte mediated immunity','P','Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity.','2013-10-27','NSRP'),(2082,2707,'negative regulation of lymphocyte mediated immunity','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity.','2013-10-27','NSRP'),(2083,2708,'positive regulation of lymphocyte mediated immunity','P','Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity.','2013-10-27','NSRP'),(2084,2709,'regulation of T cell mediated immunity','P','Any process that modulates the frequency, rate, or extent of T cell mediated immunity.','2013-10-27','NSRP'),(2085,2710,'negative regulation of T cell mediated immunity','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity.','2013-10-27','NSRP'),(2086,2711,'positive regulation of T cell mediated immunity','P','Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity.','2013-10-27','NSRP'),(2087,2712,'regulation of B cell mediated immunity','P','Any process that modulates the frequency, rate, or extent of B cell mediated immunity.','2013-10-27','NSRP'),(2088,2713,'negative regulation of B cell mediated immunity','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity.','2013-10-27','NSRP'),(2089,2714,'positive regulation of B cell mediated immunity','P','Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity.','2013-10-27','NSRP'),(2090,2715,'regulation of natural killer cell mediated immunity','P','Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity.','2013-10-27','NSRP'),(2091,2716,'negative regulation of natural killer cell mediated immunity','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity.','2013-10-27','NSRP'),(2092,2717,'positive regulation of natural killer cell mediated immunity','P','Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity.','2013-10-27','NSRP'),(2093,2718,'regulation of cytokine production involved in immune response','P','Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response.','2013-10-27','NSRP'),(2094,2719,'negative regulation of cytokine production involved in immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response.','2013-10-27','NSRP'),(2095,2720,'positive regulation of cytokine production involved in immune response','P','Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.','2013-10-27','NSRP'),(2096,2721,'regulation of B cell cytokine production','P','Any process that modulates the frequency, rate, or extent of B cell cytokine production.','2013-10-27','NSRP'),(2097,2722,'negative regulation of B cell cytokine production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production.','2013-10-27','NSRP'),(2098,2723,'positive regulation of B cell cytokine production','P','Any process that activates or increases the frequency, rate, or extent of B cell cytokine production.','2013-10-27','NSRP'),(2099,2724,'regulation of T cell cytokine production','P','Any process that modulates the frequency, rate, or extent of T cell cytokine production.','2013-10-27','NSRP'),(2100,2725,'negative regulation of T cell cytokine production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.','2013-10-27','NSRP'),(2101,2726,'positive regulation of T cell cytokine production','P','Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.','2013-10-27','NSRP'),(2102,2727,'regulation of natural killer cell cytokine production','P','Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production.','2013-10-27','NSRP'),(2103,2728,'negative regulation of natural killer cell cytokine production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production.','2013-10-27','NSRP'),(2104,2729,'positive regulation of natural killer cell cytokine production','P','Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.','2013-10-27','NSRP'),(2105,2730,'regulation of dendritic cell cytokine production','P','Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.','2013-10-27','NSRP'),(2106,2731,'negative regulation of dendritic cell cytokine production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.','2013-10-27','NSRP'),(2107,2732,'positive regulation of dendritic cell cytokine production','P','Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.','2013-10-27','NSRP'),(2108,2733,'regulation of myeloid dendritic cell cytokine production','P','Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.','2013-10-27','NSRP'),(2109,2734,'negative regulation of myeloid dendritic cell cytokine production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production.','2013-10-27','NSRP'),(2110,2735,'positive regulation of myeloid dendritic cell cytokine production','P','Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.','2013-10-27','NSRP'),(2111,2736,'regulation of plasmacytoid dendritic cell cytokine production','P','Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.','2013-10-27','NSRP'),(2112,2737,'negative regulation of plasmacytoid dendritic cell cytokine production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.','2013-10-27','NSRP'),(2113,2738,'positive regulation of plasmacytoid dendritic cell cytokine production','P','Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.','2013-10-27','NSRP'),(2114,2739,'regulation of cytokine secretion involved in immune response','P','Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response.','2013-10-27','NSRP'),(2115,2740,'negative regulation of cytokine secretion involved in immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response.','2013-10-27','NSRP'),(2116,2741,'positive regulation of cytokine secretion involved in immune response','P','Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response.','2013-10-27','NSRP'),(2117,2742,'regulation of cytokine biosynthetic process involved in immune response','P','Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response.','2013-10-27','NSRP'),(2118,2743,'negative regulation of cytokine biosynthetic process involved in immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response.','2013-10-27','NSRP'),(2119,2744,'positive regulation of cytokine biosynthetic process involved in immune response','P','Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response.','2013-10-27','NSRP'),(2120,2745,'antigen processing and presentation initiated by receptor mediated uptake of antigen','P','Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor.','2013-10-27','NSRP'),(2121,2746,'antigen processing and presentation following pinocytosis','P','Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis.','2013-10-27','NSRP'),(2122,2747,'antigen processing and presentation following phagocytosis','P','Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis.','2013-10-27','NSRP'),(2123,2748,'antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen','P','Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR).','2013-10-27','NSRP'),(2124,2749,'antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen','P','Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR).','2013-10-27','NSRP'),(2125,2750,'antigen processing and presentation following macropinocytosis','P','Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis.','2013-10-27','NSRP'),(2126,2751,'antigen processing and presentation following receptor mediated endocytosis','P','Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis.','2013-10-27','NSRP'),(2127,2752,'cell surface pattern recognition receptor signaling pathway','P','Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.','2013-10-27','NSRP'),(2128,2753,'cytoplasmic pattern recognition receptor signaling pathway','P','Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.','2013-10-27','NSRP'),(2129,2754,'intracellular vesicle pattern recognition receptor signaling pathway','P','Any series of molecular signals generated as a consequence of an intracellular vesicle pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.','2013-10-27','NSRP'),(2130,2755,'MyD88-dependent toll-like receptor signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.','2013-10-27','NSRP'),(2131,2756,'MyD88-independent toll-like receptor signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.','2013-10-27','NSRP'),(2132,2757,'immune response-activating signal transduction','P','The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response.','2013-10-27','NSRP'),(2133,2758,'innate immune response-activating signal transduction','P','The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response.','2013-10-27','NSRP'),(2134,2759,'regulation of antimicrobial humoral response','P','Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.','2013-10-27','NSRP'),(2135,2760,'positive regulation of antimicrobial humoral response','P','Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response.','2013-10-27','NSRP'),(2136,2761,'regulation of myeloid leukocyte differentiation','P','Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.','2013-10-27','NSRP'),(2137,2762,'negative regulation of myeloid leukocyte differentiation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.','2013-10-27','NSRP'),(2138,2763,'positive regulation of myeloid leukocyte differentiation','P','Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.','2013-10-27','NSRP'),(2139,2764,'immune response-regulating signaling pathway','P','The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response.','2013-10-27','NSRP'),(2140,2765,'immune response-inhibiting signal transduction','P','The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response.','2013-10-27','NSRP'),(2141,2766,'innate immune response-inhibiting signal transduction','P','The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response.','2013-10-27','NSRP'),(2142,2767,'immune response-inhibiting cell surface receptor signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.','2013-10-27','NSRP'),(2143,2768,'immune response-regulating cell surface receptor signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.','2013-10-27','NSRP'),(2144,2769,'natural killer cell inhibitory signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response.','2013-10-27','NSRP'),(2145,2770,'T cell inhibitory signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response.','2013-10-27','NSRP'),(2146,2771,'inhibitory killer cell immunoglobulin-like receptor signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response.','2013-10-27','NSRP'),(2147,2772,'inhibitory C-type lectin receptor signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response.','2013-10-27','NSRP'),(2148,2773,'B cell inhibitory signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response.','2013-10-27','NSRP'),(2149,2774,'Fc receptor mediated inhibitory signaling pathway','P','A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.','2013-10-27','NSRP'),(2150,2775,'antimicrobial peptide production','P','The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.','2013-10-27','NSRP'),(2151,2776,'antimicrobial peptide secretion','P','The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.','2013-10-27','NSRP'),(2152,2777,'antimicrobial peptide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.','2013-10-27','NSRP'),(2153,2778,'antibacterial peptide production','P','The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels.','2013-10-27','NSRP'),(2154,2779,'antibacterial peptide secretion','P','The regulated release of an antibacterial peptide from a cell or a tissue.','2013-10-27','NSRP'),(2155,2780,'antibacterial peptide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an antibacterial peptide.','2013-10-27','NSRP'),(2156,2781,'antifungal peptide production','P','The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels.','2013-10-27','NSRP'),(2157,2782,'antifungal peptide secretion','P','The regulated release of an antifungal peptide from a cell or a tissue.','2013-10-27','NSRP'),(2158,2783,'antifungal peptide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an antifungal peptide.','2013-10-27','NSRP'),(2159,2784,'regulation of antimicrobial peptide production','P','Any process that modulates the frequency, rate, or extent of antimicrobial peptide production.','2013-10-27','NSRP'),(2160,2785,'negative regulation of antimicrobial peptide production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.','2013-10-27','NSRP'),(2161,2786,'regulation of antibacterial peptide production','P','Any process that modulates the frequency, rate, or extent of antibacterial peptide production.','2013-10-27','NSRP'),(2162,2787,'negative regulation of antibacterial peptide production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production.','2013-10-27','NSRP'),(2163,2788,'regulation of antifungal peptide production','P','Any process that modulates the frequency, rate, or extent of antifungal peptide production.','2013-10-27','NSRP'),(2164,2789,'negative regulation of antifungal peptide production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production.','2013-10-27','NSRP'),(2165,2790,'peptide secretion','P','The controlled release of a peptide from a cell or a tissue.','2013-10-27','NSRP'),(2166,2791,'regulation of peptide secretion','P','Any process that modulates the frequency, rate, or extent of peptide secretion.','2013-10-27','NSRP'),(2167,2792,'negative regulation of peptide secretion','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.','2013-10-27','NSRP'),(2168,2793,'positive regulation of peptide secretion','P','Any process that activates or increases the frequency, rate, or extent of peptide secretion.','2013-10-27','NSRP'),(2169,2794,'regulation of antimicrobial peptide secretion','P','Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion.','2013-10-27','NSRP'),(2170,2795,'negative regulation of antimicrobial peptide secretion','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion.','2013-10-27','NSRP'),(2171,2796,'positive regulation of antimicrobial peptide secretion','P','Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion.','2013-10-27','NSRP'),(2172,2797,'regulation of antibacterial peptide secretion','P','Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion.','2013-10-27','NSRP'),(2173,2798,'negative regulation of antibacterial peptide secretion','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion.','2013-10-27','NSRP'),(2174,2799,'positive regulation of antibacterial peptide secretion','P','Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion.','2013-10-27','NSRP'),(2175,2800,'regulation of antifungal peptide secretion','P','Any process that modulates the frequency, rate, or extent of antifungal peptide secretion.','2013-10-27','NSRP'),(2176,2801,'negative regulation of antifungal peptide secretion','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion.','2013-10-27','NSRP'),(2177,2802,'positive regulation of antifungal peptide secretion','P','Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion.','2013-10-27','NSRP'),(2178,2803,'positive regulation of antibacterial peptide production','P','Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production.','2013-10-27','NSRP'),(2179,2804,'positive regulation of antifungal peptide production','P','Any process that activates or increases the frequency, rate, or extent of antifungal peptide production.','2013-10-27','NSRP'),(2180,2805,'regulation of antimicrobial peptide biosynthetic process','P','Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis.','2013-10-27','NSRP'),(2181,2806,'negative regulation of antimicrobial peptide biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis.','2013-10-27','NSRP'),(2182,2807,'positive regulation of antimicrobial peptide biosynthetic process','P','Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis.','2013-10-27','NSRP'),(2183,2808,'regulation of antibacterial peptide biosynthetic process','P','Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis.','2013-10-27','NSRP'),(2184,2809,'negative regulation of antibacterial peptide biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis.','2013-10-27','NSRP'),(2185,2810,'regulation of antifungal peptide biosynthetic process','P','Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis.','2013-10-27','NSRP'),(2186,2811,'negative regulation of antifungal peptide biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis.','2013-10-27','NSRP'),(2187,2812,'biosynthetic process of antibacterial peptides active against Gram-negative bacteria','P','The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria.','2013-10-27','NSRP'),(2188,2813,'regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria','P','Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.','2013-10-27','NSRP'),(2189,2814,'negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria.','2013-10-27','NSRP'),(2190,2815,'biosynthetic process of antibacterial peptides active against Gram-positive bacteria','P','The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria.','2013-10-27','NSRP'),(2191,2816,'regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria','P','Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.','2013-10-27','NSRP'),(2192,2817,'negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria.','2013-10-27','NSRP'),(2193,2818,'intracellular defense response','P','A physiological defense response which occurs intracellularly.','2013-10-27','NSRP'),(2194,2819,'regulation of adaptive immune response','P','Any process that modulates the frequency, rate, or extent of an adaptive immune response.','2013-10-27','NSRP'),(2195,2820,'negative regulation of adaptive immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response.','2013-10-27','NSRP'),(2196,2821,'positive regulation of adaptive immune response','P','Any process that activates or increases the frequency, rate, or extent of an adaptive immune response.','2013-10-27','NSRP'),(2197,2822,'regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains','P','Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.','2013-10-27','NSRP'),(2198,2823,'negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.','2013-10-27','NSRP'),(2199,2824,'positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains','P','Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.','2013-10-27','NSRP'),(2200,2825,'regulation of T-helper 1 type immune response','P','Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response.','2013-10-27','NSRP'),(2201,2826,'negative regulation of T-helper 1 type immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.','2013-10-27','NSRP'),(2202,2827,'positive regulation of T-helper 1 type immune response','P','Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response.','2013-10-27','NSRP'),(2203,2828,'regulation of type 2 immune response','P','Any process that modulates the frequency, rate, or extent of a type 2 immune response.','2013-10-27','NSRP'),(2204,2829,'negative regulation of type 2 immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response.','2013-10-27','NSRP'),(2205,2830,'positive regulation of type 2 immune response','P','Any process that activates or increases the frequency, rate, or extent of a type 2 immune response.','2013-10-27','NSRP'),(2206,2831,'regulation of response to biotic stimulus','P','Any process that modulates the frequency, rate, or extent of a response to biotic stimulus.','2013-10-27','NSRP'),(2207,2832,'negative regulation of response to biotic stimulus','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus.','2013-10-27','NSRP'),(2208,2833,'positive regulation of response to biotic stimulus','P','Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus.','2013-10-27','NSRP'),(2209,2834,'regulation of response to tumor cell','P','Any process that modulates the frequency, rate, or extent of a response to tumor cell.','2013-10-27','NSRP'),(2210,2835,'negative regulation of response to tumor cell','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell.','2013-10-27','NSRP'),(2211,2836,'positive regulation of response to tumor cell','P','Any process that activates or increases the frequency, rate, or extent of a response to tumor cell.','2013-10-27','NSRP'),(2212,2837,'regulation of immune response to tumor cell','P','Any process that modulates the frequency, rate, or extent of an immune response to tumor cell.','2013-10-27','NSRP'),(2213,2838,'negative regulation of immune response to tumor cell','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell.','2013-10-27','NSRP'),(2214,2839,'positive regulation of immune response to tumor cell','P','Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell.','2013-10-27','NSRP'),(2215,2840,'regulation of T cell mediated immune response to tumor cell','P','Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell.','2013-10-27','NSRP'),(2216,2841,'negative regulation of T cell mediated immune response to tumor cell','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell.','2013-10-27','NSRP'),(2217,2842,'positive regulation of T cell mediated immune response to tumor cell','P','Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell.','2013-10-27','NSRP'),(2218,2843,'regulation of tolerance induction to tumor cell','P','Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell.','2013-10-27','NSRP'),(2219,2844,'negative regulation of tolerance induction to tumor cell','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell.','2013-10-27','NSRP'),(2220,2845,'positive regulation of tolerance induction to tumor cell','P','Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell.','2013-10-27','NSRP'),(2221,2846,'regulation of T cell tolerance induction to tumor cell','P','Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell.','2013-10-27','NSRP'),(2222,2847,'negative regulation of T cell tolerance induction to tumor cell','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell.','2013-10-27','NSRP'),(2223,2848,'positive regulation of T cell tolerance induction to tumor cell','P','Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell.','2013-10-27','NSRP'),(2224,2849,'regulation of peripheral T cell tolerance induction','P','Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction.','2013-10-27','NSRP'),(2225,2850,'negative regulation of peripheral T cell tolerance induction','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction.','2013-10-27','NSRP'),(2226,2851,'positive regulation of peripheral T cell tolerance induction','P','Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction.','2013-10-27','NSRP'),(2227,2852,'regulation of T cell mediated cytotoxicity directed against tumor cell target','P','Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.','2013-10-27','NSRP'),(2228,2853,'negative regulation of T cell mediated cytotoxicity directed against tumor cell target','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.','2013-10-27','NSRP'),(2229,2854,'positive regulation of T cell mediated cytotoxicity directed against tumor cell target','P','Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target.','2013-10-27','NSRP'),(2230,2855,'regulation of natural killer cell mediated immune response to tumor cell','P','Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.','2013-10-27','NSRP'),(2231,2856,'negative regulation of natural killer cell mediated immune response to tumor cell','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.','2013-10-27','NSRP'),(2232,2857,'positive regulation of natural killer cell mediated immune response to tumor cell','P','Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell.','2013-10-27','NSRP'),(2233,2858,'regulation of natural killer cell mediated cytotoxicity directed against tumor cell target','P','Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.','2013-10-27','NSRP'),(2234,2859,'negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.','2013-10-27','NSRP'),(2235,2860,'positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target','P','Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.','2013-10-27','NSRP'),(2236,2861,'regulation of inflammatory response to antigenic stimulus','P','Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.','2013-10-27','NSRP'),(2237,2862,'negative regulation of inflammatory response to antigenic stimulus','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.','2013-10-27','NSRP'),(2238,2863,'positive regulation of inflammatory response to antigenic stimulus','P','Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus.','2013-10-27','NSRP'),(2239,2864,'regulation of acute inflammatory response to antigenic stimulus','P','Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.','2013-10-27','NSRP'),(2240,2865,'negative regulation of acute inflammatory response to antigenic stimulus','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.','2013-10-27','NSRP'),(2241,2866,'positive regulation of acute inflammatory response to antigenic stimulus','P','Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus.','2013-10-27','NSRP'),(2242,2867,'regulation of B cell deletion','P','Any process that modulates the frequency, rate, or extent of B cell deletion.','2013-10-27','NSRP'),(2243,2868,'negative regulation of B cell deletion','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion.','2013-10-27','NSRP'),(2244,2869,'positive regulation of B cell deletion','P','Any process that activates or increases the frequency, rate, or extent of B cell deletion.','2013-10-27','NSRP'),(2245,2870,'T cell anergy','P','Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction.','2013-10-27','NSRP'),(2246,2871,'regulation of natural killer cell tolerance induction','P','Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction.','2013-10-27','NSRP'),(2247,2872,'negative regulation of natural killer cell tolerance induction','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction.','2013-10-27','NSRP'),(2248,2873,'positive regulation of natural killer cell tolerance induction','P','Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction.','2013-10-27','NSRP'),(2249,2874,'regulation of chronic inflammatory response to antigenic stimulus','P','Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.','2013-10-27','NSRP'),(2250,2875,'negative regulation of chronic inflammatory response to antigenic stimulus','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.','2013-10-27','NSRP'),(2251,2876,'positive regulation of chronic inflammatory response to antigenic stimulus','P','Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus.','2013-10-27','NSRP'),(2252,2877,'regulation of acute inflammatory response to non-antigenic stimulus','P','Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.','2013-10-27','NSRP'),(2253,2878,'negative regulation of acute inflammatory response to non-antigenic stimulus','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.','2013-10-27','NSRP'),(2254,2879,'positive regulation of acute inflammatory response to non-antigenic stimulus','P','Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus.','2013-10-27','NSRP'),(2255,2880,'regulation of chronic inflammatory response to non-antigenic stimulus','P','Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.','2013-10-27','NSRP'),(2256,2881,'negative regulation of chronic inflammatory response to non-antigenic stimulus','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.','2013-10-27','NSRP'),(2257,2882,'positive regulation of chronic inflammatory response to non-antigenic stimulus','P','Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus.','2013-10-27','NSRP'),(2258,2883,'regulation of hypersensitivity','P','Any process that modulates the frequency, rate, or extent of hypersensitivity.','2013-10-27','NSRP'),(2259,2884,'negative regulation of hypersensitivity','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity.','2013-10-27','NSRP'),(2260,2885,'positive regulation of hypersensitivity','P','Any process that activates or increases the frequency, rate, or extent of hypersensitivity.','2013-10-27','NSRP'),(2261,2886,'regulation of myeloid leukocyte mediated immunity','P','Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity.','2013-10-27','NSRP'),(2262,2887,'negative regulation of myeloid leukocyte mediated immunity','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity.','2013-10-27','NSRP'),(2263,2888,'positive regulation of myeloid leukocyte mediated immunity','P','Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity.','2013-10-27','NSRP'),(2264,2889,'regulation of immunoglobulin mediated immune response','P','Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response.','2013-10-27','NSRP'),(2265,2890,'negative regulation of immunoglobulin mediated immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response.','2013-10-27','NSRP'),(2266,2891,'positive regulation of immunoglobulin mediated immune response','P','Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response.','2013-10-27','NSRP'),(2267,2892,'regulation of type II hypersensitivity','P','Any process that modulates the frequency, rate, or extent of type II hypersensitivity.','2013-10-27','NSRP'),(2268,2893,'negative regulation of type II hypersensitivity','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity.','2013-10-27','NSRP'),(2269,2894,'positive regulation of type II hypersensitivity','P','Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity.','2013-10-27','NSRP'),(2270,2895,'regulation of central B cell tolerance induction','P','Any process that modulates the frequency, rate, or extent of central B cell tolerance induction.','2013-10-27','NSRP'),(2271,2896,'negative regulation of central B cell tolerance induction','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction.','2013-10-27','NSRP'),(2272,2897,'positive regulation of central B cell tolerance induction','P','Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction.','2013-10-27','NSRP'),(2273,2898,'regulation of central B cell deletion','P','Any process that modulates the frequency, rate, or extent of central B cell deletion.','2013-10-27','NSRP'),(2274,2899,'negative regulation of central B cell deletion','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion.','2013-10-27','NSRP'),(2275,2900,'positive regulation of central B cell deletion','P','Any process that activates or increases the frequency, rate, or extent of central B cell deletion.','2013-10-27','NSRP'),(2276,2901,'mature B cell apoptotic process','P','Any apoptotic process in a B cell that is mature, having left the bone marrow.','2013-10-27','NSRP'),(2277,2902,'regulation of B cell apoptotic process','P','Any process that modulates the frequency, rate, or extent of B cell apoptotic process.','2013-10-27','NSRP'),(2278,2903,'negative regulation of B cell apoptotic process','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.','2013-10-27','NSRP'),(2279,2904,'positive regulation of B cell apoptotic process','P','Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process.','2013-10-27','NSRP'),(2280,2905,'regulation of mature B cell apoptotic process','P','Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process.','2013-10-27','NSRP'),(2281,2906,'negative regulation of mature B cell apoptotic process','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process.','2013-10-27','NSRP'),(2282,2907,'positive regulation of mature B cell apoptotic process','P','Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process.','2013-10-27','NSRP'),(2283,2908,'regulation of peripheral B cell deletion','P','Any process that modulates the frequency, rate, or extent of peripheral B cell deletion.','2013-10-27','NSRP'),(2284,2909,'negative regulation of peripheral B cell deletion','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion.','2013-10-27','NSRP'),(2285,2910,'positive regulation of peripheral B cell deletion','P','Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion.','2013-10-27','NSRP'),(2286,2911,'regulation of lymphocyte anergy','P','Any process that modulates the frequency, rate, or extent of lymphocyte anergy.','2013-10-27','NSRP'),(2287,2912,'negative regulation of lymphocyte anergy','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy.','2013-10-27','NSRP'),(2288,2913,'positive regulation of lymphocyte anergy','P','Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy.','2013-10-27','NSRP'),(2289,2914,'regulation of central B cell anergy','P','Any process that modulates the frequency, rate, or extent of central B cell anergy.','2013-10-27','NSRP'),(2290,2915,'negative regulation of central B cell anergy','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy.','2013-10-27','NSRP'),(2291,2916,'positive regulation of central B cell anergy','P','Any process that activates or increases the frequency, rate, or extent of central B cell anergy.','2013-10-27','NSRP'),(2292,2917,'regulation of peripheral B cell anergy','P','Any process that modulates the frequency, rate, or extent of peripheral B cell anergy.','2013-10-27','NSRP'),(2293,2918,'negative regulation of peripheral B cell anergy','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy.','2013-10-27','NSRP'),(2294,2919,'positive regulation of peripheral B cell anergy','P','Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy.','2013-10-27','NSRP'),(2295,2920,'regulation of humoral immune response','P','Any process that modulates the frequency, rate, or extent of a humoral immune response.','2013-10-27','NSRP'),(2296,2921,'negative regulation of humoral immune response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.','2013-10-27','NSRP'),(2297,2922,'positive regulation of humoral immune response','P','Any process that activates or increases the frequency, rate, or extent of a humoral immune response.','2013-10-27','NSRP'),(2298,2923,'regulation of humoral immune response mediated by circulating immunoglobulin','P','Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.','2013-10-27','NSRP'),(2299,2924,'negative regulation of humoral immune response mediated by circulating immunoglobulin','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.','2013-10-27','NSRP'),(2300,2925,'positive regulation of humoral immune response mediated by circulating immunoglobulin','P','Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.','2013-10-27','NSRP'),(2301,3001,'generation of a signal involved in cell-cell signaling','P','The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal.','2013-10-27','NSRP'),(2302,3002,'regionalization','P','The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.','2013-10-27','NSRP'),(2303,3003,'follicular fluid formation in ovarian follicle antrum involved in fused antrum stage','P','The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis.','2013-10-27','NSRP'),(2304,3004,'follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage','P','The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis.','2013-10-27','NSRP'),(2305,3005,'follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage','P','The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis.','2013-10-27','NSRP'),(2306,3006,'developmental process involved in reproduction','P','A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring.','2013-10-27','NSRP'),(2307,3007,'heart morphogenesis','P','The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.','2013-10-27','NSRP'),(2308,3008,'system process','P','A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective.','2013-10-27','NSRP'),(2309,3009,'skeletal muscle contraction','P','A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control.','2013-10-27','NSRP'),(2310,3010,'voluntary skeletal muscle contraction','P','A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control.','2013-10-27','NSRP'),(2311,3011,'involuntary skeletal muscle contraction','P','A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control.','2013-10-27','NSRP'),(2312,3012,'muscle system process','P','A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers.','2013-10-27','NSRP'),(2313,3013,'circulatory system process','P','A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism.','2013-10-27','NSRP'),(2314,3014,'renal system process','P','A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism.','2013-10-27','NSRP'),(2315,3015,'heart process','P','A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.','2013-10-27','NSRP'),(2316,3016,'respiratory system process','P','A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange.','2013-10-27','NSRP'),(2317,3017,'lymph circulation','P','The flow of lymph through the body of an animal.','2013-10-27','NSRP'),(2318,3018,'vascular process in circulatory system','P','A circulatory process that occurs at the level of the vasculature.','2013-10-27','NSRP'),(2319,3019,'central nervous system control of baroreceptor feedback','P','The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris.','2013-10-27','NSRP'),(2320,3020,'detection of reduced oxygen by chemoreceptor signaling','P','The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.','2013-10-27','NSRP'),(2321,3021,'detection of increased carbon dioxide by chemoreceptor signaling','P','The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.','2013-10-27','NSRP'),(2322,3022,'detection of pH by chemoreceptor signaling','P','The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies.','2013-10-27','NSRP'),(2323,3023,'baroreceptor detection of increased arterial stretch','P','The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal.','2013-10-27','NSRP'),(2324,3024,'baroreceptor detection of decreased arterial stretch','P','The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal.','2013-10-27','NSRP'),(2325,3025,'regulation of systemic arterial blood pressure by baroreceptor feedback','P','The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control.','2013-10-27','NSRP'),(2326,3026,'regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback','P','The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control.','2013-10-27','NSRP'),(2327,3027,'regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling','P','The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.','2013-10-27','NSRP'),(2328,3028,'regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling','P','The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions.','2013-10-27','NSRP'),(2329,3029,'detection of hypoxic conditions in blood by carotid body chemoreceptor signaling','P','The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies.','2013-10-27','NSRP'),(2330,3030,'detection of hydrogen ion','P','The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(2331,3031,'detection of carbon dioxide','P','The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(2332,3032,'detection of oxygen','P','The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(2333,3033,'detection of hypoxic conditions in blood by aortic body chemoreceptor signaling','P','The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies.','2013-10-27','NSRP'),(2334,3034,'detection of increased carbon dioxide by aortic body chemoreceptor signaling','P','The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body.','2013-10-27','NSRP'),(2335,3035,'detection of increased carbon dioxide by carotid body chemoreceptor signaling','P','The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body.','2013-10-27','NSRP'),(2336,3036,'detection of pH by aortic body chemoreceptor signaling','P','The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body.','2013-10-27','NSRP'),(2337,3037,'detection of pH by carotid body chemoreceptor signaling','P','The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body.','2013-10-27','NSRP'),(2338,3038,'detection of reduced oxygen by aortic body chemoreceptor signaling','P','The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body.','2013-10-27','NSRP'),(2339,3039,'detection of reduced oxygen by carotid body chemoreceptor signaling','P','The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body.','2013-10-27','NSRP'),(2340,3040,'excitation of vasomotor center by aortic body chemoreceptor signaling','P','The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.','2013-10-27','NSRP'),(2341,3041,'excitation of vasomotor center by carotid body chemoreceptor signaling','P','The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure.','2013-10-27','NSRP'),(2342,3042,'vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure','P','A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.','2013-10-27','NSRP'),(2343,3043,'vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure','P','A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure.','2013-10-27','NSRP'),(2344,3044,'regulation of systemic arterial blood pressure mediated by a chemical signal','P','The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine.','2013-10-27','NSRP'),(2345,3045,'regulation of systemic arterial blood pressure by physical factors','P','The regulation of blood pressure mediated by detection of forces within the circulatory system.','2013-10-27','NSRP'),(2346,3046,'regulation of systemic arterial blood pressure by stress relaxation','P','The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs.','2013-10-27','NSRP'),(2347,3047,'regulation of systemic arterial blood pressure by epinephrine','P','The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine.','2013-10-27','NSRP'),(2348,3048,'regulation of systemic arterial blood pressure by norepinephrine','P','The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine.','2013-10-27','NSRP'),(2349,3049,'regulation of systemic arterial blood pressure by capillary fluid shift','P','The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment.','2013-10-27','NSRP'),(2350,3050,'regulation of systemic arterial blood pressure by atrial natriuretic peptide','P','The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide.','2013-10-27','NSRP'),(2351,3051,'angiotensin-mediated drinking behavior','P','The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst.','2013-10-27','NSRP'),(2352,3052,'circadian regulation of systemic arterial blood pressure','P','Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours.','2013-10-27','NSRP'),(2353,3053,'circadian regulation of heart rate','P','Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours.','2013-10-27','NSRP'),(2354,3054,'circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus','P','The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours.','2013-10-27','NSRP'),(2355,3055,'circadian regulation of heart rate by the suprachiasmatic nucleus','P','The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours.','2013-10-27','NSRP'),(2356,3056,'regulation of vascular smooth muscle contraction','P','Any process that increases the frequency, rate or extent of vascular smooth muscle contraction.','2013-10-27','NSRP'),(2357,3057,'regulation of the force of heart contraction by chemical signal','P','The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.','2013-10-27','NSRP'),(2358,3058,'hormonal regulation of the force of heart contraction','P','The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.','2013-10-27','NSRP'),(2359,3059,'positive regulation of the force of heart contraction by epinephrine','P','The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction.','2013-10-27','NSRP'),(2360,3060,'negative regulation of the force of heart contraction by acetylcholine','P','The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction.','2013-10-27','NSRP'),(2361,3061,'positive regulation of the force of heart contraction by norepinephrine','P','The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction.','2013-10-27','NSRP'),(2362,3062,'regulation of heart rate by chemical signal','P','The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.','2013-10-27','NSRP'),(2363,3063,'negative regulation of heart rate by acetylcholine','P','The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction.','2013-10-27','NSRP'),(2364,3064,'regulation of heart rate by hormone','P','The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.','2013-10-27','NSRP'),(2365,3065,'positive regulation of heart rate by epinephrine','P','The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.','2013-10-27','NSRP'),(2366,3066,'positive regulation of heart rate by norepinephrine','P','The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction.','2013-10-27','NSRP'),(2367,3067,'circadian regulation of systemic arterial blood pressure by hormone','P','The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action.','2013-10-27','NSRP'),(2368,3068,'regulation of systemic arterial blood pressure by acetylcholine','P','The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter.','2013-10-27','NSRP'),(2369,3069,'vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure','P','The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure.','2013-10-27','NSRP'),(2370,3070,'regulation of systemic arterial blood pressure by neurotransmitter','P','The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.','2013-10-27','NSRP'),(2371,3071,'renal system process involved in regulation of systemic arterial blood pressure','P','Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.','2013-10-27','NSRP'),(2372,3072,'renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure','P','The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature.','2013-10-27','NSRP'),(2373,3073,'regulation of systemic arterial blood pressure','P','The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.','2013-10-27','NSRP'),(2374,3074,'regulation of diuresis','P','OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion.','2013-10-27','NSRP'),(2375,3075,'renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure','P','The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system.','2013-10-27','NSRP'),(2376,3077,'negative regulation of diuresis','P','OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion.','2013-10-27','NSRP'),(2377,3078,'regulation of natriuresis','P','OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion.','2013-10-27','NSRP'),(2378,3079,'positive regulation of natriuresis','P','OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis.','2013-10-27','NSRP'),(2379,3080,'negative regulation of natriuresis','P','OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion.','2013-10-27','NSRP'),(2380,3081,'regulation of systemic arterial blood pressure by renin-angiotensin','P','The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.','2013-10-27','NSRP'),(2381,3082,'positive regulation of renal output by angiotensin','P','OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney.','2013-10-27','NSRP'),(2382,3083,'negative regulation of renal output by angiotensin','P','The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney.','2013-10-27','NSRP'),(2383,3084,'positive regulation of systemic arterial blood pressure','P','The process that increases the force with which blood travels through the systemic arterial circulatory system.','2013-10-27','NSRP'),(2384,3085,'negative regulation of systemic arterial blood pressure','P','The process that reduces the force with which blood travels through the systemic arterial circulatory system.','2013-10-27','NSRP'),(2385,3086,'regulation of systemic arterial blood pressure by local renal renin-angiotensin','P','The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen.','2013-10-27','NSRP'),(2386,3087,'positive regulation of the force of heart contraction by neuronal epinephrine','P','The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction.','2013-10-27','NSRP'),(2387,3088,'positive regulation of the force of heart contraction by circulating epinephrine','P','The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction.','2013-10-27','NSRP'),(2388,3089,'positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine','P','Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream.','2013-10-27','NSRP'),(2389,3090,'positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine','P','Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings.','2013-10-27','NSRP'),(2390,3091,'renal water homeostasis','P','Renal process involved in the maintenance of an internal steady state of water in the body.','2013-10-27','NSRP'),(2391,3092,'renal water retention','P','The process in which renal water excretion is decreased.','2013-10-27','NSRP'),(2392,3093,'regulation of glomerular filtration','P','Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule.','2013-10-27','NSRP'),(2393,3094,'glomerular filtration','P','The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.','2013-10-27','NSRP'),(2394,3095,'pressure natriuresis','P','The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis).','2013-10-27','NSRP'),(2395,3096,'renal sodium ion transport','P','The directed movement of sodium ions (Na+) by the kidney.','2013-10-27','NSRP'),(2396,3097,'renal water transport','P','The directed movement of water (H2O) by the kidney.','2013-10-27','NSRP'),(2397,3098,'tubuloglomerular feedback','P','The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus.','2013-10-27','NSRP'),(2398,3099,'positive regulation of the force of heart contraction by chemical signal','P','Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.','2013-10-27','NSRP'),(2399,3100,'regulation of systemic arterial blood pressure by endothelin','P','The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor.','2013-10-27','NSRP'),(2400,3101,'regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine','P','The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system.','2013-10-27','NSRP'),(2401,3102,'positive regulation of diuresis by angiotensin','P','OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis.','2013-10-27','NSRP'),(2402,3103,'positive regulation of diuresis','P','OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion.','2013-10-27','NSRP'),(2403,3104,'positive regulation of glomerular filtration','P','Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.','2013-10-27','NSRP'),(2404,3105,'negative regulation of glomerular filtration','P','Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.','2013-10-27','NSRP'),(2405,3106,'negative regulation of glomerular filtration by angiotensin','P','The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule.','2013-10-27','NSRP'),(2406,3107,'positive regulation of natriuresis by angiotensin','P','OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion.','2013-10-27','NSRP'),(2407,3108,'negative regulation of the force of heart contraction by chemical signal','P','Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.','2013-10-27','NSRP'),(2408,3109,'positive regulation of the force of heart contraction by circulating norepinephrine','P','The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction.','2013-10-27','NSRP'),(2409,3110,'positive regulation of the force of heart contraction by neuronal norepinephrine','P','The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction.','2013-10-27','NSRP'),(2410,3111,'positive regulation of heart rate by circulating epinephrine','P','The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction.','2013-10-27','NSRP'),(2411,3112,'positive regulation of heart rate by neuronal epinephrine','P','The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction.','2013-10-27','NSRP'),(2412,3113,'positive regulation of heart rate by neuronal norepinephrine','P','The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction.','2013-10-27','NSRP'),(2413,3114,'positive regulation of heart rate by circulating norepinephrine','P','The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction.','2013-10-27','NSRP'),(2414,3115,'regulation of vasoconstriction by epinephrine','P','Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings.','2013-10-27','NSRP'),(2415,3116,'regulation of vasoconstriction by norepinephrine','P','Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings.','2013-10-27','NSRP'),(2416,3117,'regulation of vasoconstriction by circulating norepinephrine','P','Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.','2013-10-27','NSRP'),(2417,3118,'regulation of vasoconstriction by neuronal norepinephrine','P','Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings.','2013-10-27','NSRP'),(2418,3119,'regulation of vasoconstriction by neuronal epinephrine','P','Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings.','2013-10-27','NSRP'),(2419,3120,'regulation of vasoconstriction by circulating epinephrine','P','Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream.','2013-10-27','NSRP'),(2420,3121,'regulation of vasodilation by epinephrine','P','Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings.','2013-10-27','NSRP'),(2421,3122,'regulation of vasodilation by norepinephrine','P','Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings.','2013-10-27','NSRP'),(2422,3123,'regulation of vasodilation by circulating epinephrine','P','Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream.','2013-10-27','NSRP'),(2423,3124,'regulation of vasodilation by neuronal epinephrine','P','Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings.','2013-10-27','NSRP'),(2424,3125,'regulation of vasodilation by circulating norepinephrine','P','Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream.','2013-10-27','NSRP'),(2425,3126,'regulation of vasodilation by neuronal norepinephrine','P','Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings.','2013-10-27','NSRP'),(2426,3127,'detection of nodal flow','P','The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry.','2013-10-27','NSRP'),(2427,3128,'heart field specification','P','The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop.','2013-10-27','NSRP'),(2428,3129,'heart induction','P','The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.','2013-10-27','NSRP'),(2429,3130,'BMP signaling pathway involved in heart induction','P','A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction.','2013-10-27','NSRP'),(2430,3131,'mesodermal-endodermal cell signaling','P','Any process that mediates the transfer of information from mesodermal cells to endodermal cells.','2013-10-27','NSRP'),(2431,3132,'mesodermal-endodermal cell signaling involved in heart induction','P','Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction.','2013-10-27','NSRP'),(2432,3133,'endodermal-mesodermal cell signaling','P','Any process that mediates the transfer of information from endodermal cells to mesodermal cells.','2013-10-27','NSRP'),(2433,3134,'endodermal-mesodermal cell signaling involved in heart induction','P','Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction.','2013-10-27','NSRP'),(2434,3135,'fibroblast growth factor receptor signaling pathway involved in heart induction','P','The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction.','2013-10-27','NSRP'),(2435,3136,'negative regulation of heart induction by canonical Wnt receptor signaling pathway','P','Any canonical Wnt receptor signaling that decreases the rate, frequency or extent of heart induction.','2013-10-27','NSRP'),(2436,3137,'Notch signaling pathway involved in heart induction','P','The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.','2013-10-27','NSRP'),(2437,3138,'primary heart field specification','P','The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle.','2013-10-27','NSRP'),(2438,3139,'secondary heart field specification','P','The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract).','2013-10-27','NSRP'),(2439,3140,'determination of left/right asymmetry in lateral mesoderm','P','The establishment of the lateral mesoderm with respect to the left and right halves.','2013-10-27','NSRP'),(2440,3141,'transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry','P','OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination.','2013-10-27','NSRP'),(2441,3142,'cardiogenic plate morphogenesis','P','The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field.','2013-10-27','NSRP'),(2442,3143,'embryonic heart tube morphogenesis','P','The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.','2013-10-27','NSRP'),(2443,3144,'embryonic heart tube formation','P','The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.','2013-10-27','NSRP'),(2444,3145,'embryonic heart tube formation via epithelial folding','P','The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis.','2013-10-27','NSRP'),(2445,3146,'heart jogging','P','The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis.','2013-10-27','NSRP'),(2446,3147,'neural crest cell migration involved in heart formation','P','The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation.','2013-10-27','NSRP'),(2447,3148,'outflow tract septum morphogenesis','P','The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.','2013-10-27','NSRP'),(2448,3149,'membranous septum morphogenesis','P','The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum.','2013-10-27','NSRP'),(2449,3150,'muscular septum morphogenesis','P','The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum.','2013-10-27','NSRP'),(2450,3151,'outflow tract morphogenesis','P','The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.','2013-10-27','NSRP'),(2451,3152,'morphogenesis of an epithelial fold involved in embryonic heart tube formation','P','The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation.','2013-10-27','NSRP'),(2452,3153,'closure of embryonic heart tube','P','Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold.','2013-10-27','NSRP'),(2453,3154,'BMP signaling pathway involved in determination of left/right symmetry','P','A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry.','2013-10-27','NSRP'),(2454,3155,'BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry','P','A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry.','2013-10-27','NSRP'),(2455,3156,'regulation of organ formation','P','Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.','2013-10-27','NSRP'),(2456,3157,'endocardium development','P','The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.','2013-10-27','NSRP'),(2457,3158,'endothelium development','P','The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities,and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.','2013-10-27','NSRP'),(2458,3159,'morphogenesis of an endothelium','P','The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.','2013-10-27','NSRP'),(2459,3160,'endocardium morphogenesis','P','The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.','2013-10-27','NSRP'),(2460,3161,'cardiac conduction system development','P','The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.','2013-10-27','NSRP'),(2461,3162,'atrioventricular node development','P','The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.','2013-10-27','NSRP'),(2462,3163,'sinoatrial node development','P','The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.','2013-10-27','NSRP'),(2463,3164,'His-Purkinje system development','P','The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.','2013-10-27','NSRP'),(2464,3165,'Purkinje myocyte development','P','The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.','2013-10-27','NSRP'),(2465,3166,'bundle of His development','P','The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.','2013-10-27','NSRP'),(2466,3167,'atrioventricular bundle cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers.','2013-10-27','NSRP'),(2467,3168,'Purkinje myocyte differentiation','P','The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.','2013-10-27','NSRP'),(2468,3169,'coronary vein morphogenesis','P','The process in which the anatomical structures of veins of the heart are generated and organized.','2013-10-27','NSRP'),(2469,3170,'heart valve development','P','The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion.','2013-10-27','NSRP'),(2470,3171,'atrioventricular valve development','P','The progression of the atrioventricular valve over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2471,3172,'sinoatrial valve development','P','The progression of the sinoatrial valve over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2472,3173,'ventriculo bulbo valve development','P','The progression of the ventriculo bulbo valve over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2473,3174,'mitral valve development','P','The progression of the mitral valve over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2474,3175,'tricuspid valve development','P','The progression of the tricuspid valve over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2475,3176,'aortic valve development','P','The progression of the aortic valve over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2476,3177,'pulmonary valve development','P','The progression of the pulmonary valve over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2477,3178,'coronary sinus valve development','P','The progression of the valve of the coronary sinus over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2478,3179,'heart valve morphogenesis','P','The process in which the structure of a heart valve is generated and organized.','2013-10-27','NSRP'),(2479,3180,'aortic valve morphogenesis','P','The process in which the structure of the aortic valve is generated and organized.','2013-10-27','NSRP'),(2480,3181,'atrioventricular valve morphogenesis','P','The process in which the structure of the atrioventricular valve is generated and organized.','2013-10-27','NSRP'),(2481,3182,'coronary sinus valve morphogenesis','P','The process in which the structure of the coronary sinus valve is generated and organized.','2013-10-27','NSRP'),(2482,3183,'mitral valve morphogenesis','P','The process in which the structure of the mitral valve is generated and organized.','2013-10-27','NSRP'),(2483,3184,'pulmonary valve morphogenesis','P','The process in which the structure of the pulmonary valve is generated and organized.','2013-10-27','NSRP'),(2484,3185,'sinoatrial valve morphogenesis','P','The process in which the structure of the sinoatrial valve is generated and organized.','2013-10-27','NSRP'),(2485,3186,'tricuspid valve morphogenesis','P','The process in which the structure of the tricuspid valve is generated and organized.','2013-10-27','NSRP'),(2486,3187,'ventriculo bulbo valve morphogenesis','P','The process in which the structure of the ventriculo bulbo valve is generated and organized.','2013-10-27','NSRP'),(2487,3188,'heart valve formation','P','The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.','2013-10-27','NSRP'),(2488,3189,'aortic valve formation','P','The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.','2013-10-27','NSRP'),(2489,3190,'atrioventricular valve formation','P','The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.','2013-10-27','NSRP'),(2490,3191,'coronary sinus valve formation','P','The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.','2013-10-27','NSRP'),(2491,3192,'mitral valve formation','P','The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.','2013-10-27','NSRP'),(2492,3193,'pulmonary valve formation','P','The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.','2013-10-27','NSRP'),(2493,3194,'sinoatrial valve formation','P','The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.','2013-10-27','NSRP'),(2494,3195,'tricuspid valve formation','P','The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.','2013-10-27','NSRP'),(2495,3196,'ventriculo bulbo valve formation','P','The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable.','2013-10-27','NSRP'),(2496,3197,'endocardial cushion development','P','The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.','2013-10-27','NSRP'),(2497,3198,'epithelial to mesenchymal transition involved in endocardial cushion formation','P','A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion.','2013-10-27','NSRP'),(2498,3199,'endocardial cushion to mesenchymal transition involved in heart valve formation','P','A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve.','2013-10-27','NSRP'),(2499,3200,'endocardial cushion to mesenchymal transition involved in heart chamber septation','P','A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum.','2013-10-27','NSRP'),(2500,3201,'epithelial to mesenchymal transition involved in coronary vasculature morphogenesis','P','A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature.','2013-10-27','NSRP'),(2501,3202,'endocardial cushion to mesenchymal transition involved in cardiac skeleton development','P','A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton.','2013-10-27','NSRP'),(2502,3203,'endocardial cushion morphogenesis','P','The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.','2013-10-27','NSRP'),(2503,3204,'cardiac skeleton development','P','The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.','2013-10-27','NSRP'),(2504,3205,'cardiac chamber development','P','The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.','2013-10-27','NSRP'),(2505,3206,'cardiac chamber morphogenesis','P','The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart.','2013-10-27','NSRP'),(2506,3207,'cardiac chamber formation','P','The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart.','2013-10-27','NSRP'),(2507,3208,'cardiac ventricle morphogenesis','P','The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.','2013-10-27','NSRP'),(2508,3209,'cardiac atrium morphogenesis','P','The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.','2013-10-27','NSRP'),(2509,3210,'cardiac atrium formation','P','The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.','2013-10-27','NSRP'),(2510,3211,'cardiac ventricle formation','P','The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.','2013-10-27','NSRP'),(2511,3212,'cardiac left atrium morphogenesis','P','The process in which the left cardiac atrium is generated and organized.','2013-10-27','NSRP'),(2512,3213,'cardiac right atrium morphogenesis','P','The process in which the right cardiac atrium is generated and organized.','2013-10-27','NSRP'),(2513,3214,'cardiac left ventricle morphogenesis','P','The process in which the left cardiac ventricle is generated and organized.','2013-10-27','NSRP'),(2514,3215,'cardiac right ventricle morphogenesis','P','The process in which the right cardiac ventricle is generated and organized.','2013-10-27','NSRP'),(2515,3216,'cardiac left atrium formation','P','The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts.','2013-10-27','NSRP'),(2516,3217,'cardiac right atrium formation','P','The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts.','2013-10-27','NSRP'),(2517,3218,'cardiac left ventricle formation','P','The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts.','2013-10-27','NSRP'),(2518,3219,'cardiac right ventricle formation','P','The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts.','2013-10-27','NSRP'),(2519,3220,'left ventricular cardiac muscle tissue morphogenesis','P','The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized.','2013-10-27','NSRP'),(2520,3221,'right ventricular cardiac muscle tissue morphogenesis','P','The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized.','2013-10-27','NSRP'),(2521,3222,'ventricular trabecula myocardium morphogenesis','P','The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.','2013-10-27','NSRP'),(2522,3223,'ventricular compact myocardium morphogenesis','P','The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized.','2013-10-27','NSRP'),(2523,3224,'left ventricular compact myocardium morphogenesis','P','The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized.','2013-10-27','NSRP'),(2524,3225,'left ventricular trabecular myocardium morphogenesis','P','The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized.','2013-10-27','NSRP'),(2525,3226,'right ventricular compact myocardium morphogenesis','P','The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized.','2013-10-27','NSRP'),(2526,3227,'right ventricular trabecular myocardium morphogenesis','P','The process in which the anatomical structures of the right ventricular myocardium are generated and organized.','2013-10-27','NSRP'),(2527,3228,'atrial cardiac muscle tissue development','P','The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2528,3229,'ventricular cardiac muscle tissue development','P','The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2529,3230,'cardiac atrium development','P','The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle.','2013-10-27','NSRP'),(2530,3231,'cardiac ventricle development','P','The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.','2013-10-27','NSRP'),(2531,3232,'bulbus arteriosus development','P','The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber.','2013-10-27','NSRP'),(2532,3233,'bulbus arteriosus morphogenesis','P','The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber.','2013-10-27','NSRP'),(2533,3234,'bulbus arteriosus formation','P','The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart.','2013-10-27','NSRP'),(2534,3235,'sinus venosus development','P','The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.','2013-10-27','NSRP'),(2535,3236,'sinus venosus morphogenesis','P','The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.','2013-10-27','NSRP'),(2536,3237,'sinus venosus formation','P','The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart.','2013-10-27','NSRP'),(2537,3238,'conus arteriosus development','P','The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.','2013-10-27','NSRP'),(2538,3239,'conus arteriosus morphogenesis','P','The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.','2013-10-27','NSRP'),(2539,3240,'conus arteriosus formation','P','The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk.','2013-10-27','NSRP'),(2540,3241,'growth involved in heart morphogenesis','P','Developmental growth that contributes to the shaping of the heart.','2013-10-27','NSRP'),(2541,3242,'cardiac chamber ballooning','P','The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping.','2013-10-27','NSRP'),(2542,3243,'circumferential growth involved in left ventricle morphogenesis','P','The morphogenetic growth in which the left ventricle grows expanding its external boundary.','2013-10-27','NSRP'),(2543,3244,'radial growth involved in right ventricle morphogenesis','P','The morphogenic growth in which the right ventricle grows along a radial axis.','2013-10-27','NSRP'),(2544,3245,'cardiac muscle tissue growth involved in heart morphogenesis','P','The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart.','2013-10-27','NSRP'),(2545,3246,'embryonic cardiac muscle cell growth involved in heart morphogenesis','P','The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart.','2013-10-27','NSRP'),(2546,3247,'post-embryonic cardiac muscle cell growth involved in heart morphogenesis','P','The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart.','2013-10-27','NSRP'),(2547,3248,'heart capillary growth','P','The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle.','2013-10-27','NSRP'),(2548,3249,'cell proliferation involved in heart valve morphogenesis','P','The multiplication or reproduction of cells that contributes to the shaping of a heart valve.','2013-10-27','NSRP'),(2549,3250,'regulation of cell proliferation involved in heart valve morphogenesis','P','Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.','2013-10-27','NSRP'),(2550,3251,'positive regulation of cell proliferation involved in heart valve morphogenesis','P','Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.','2013-10-27','NSRP'),(2551,3252,'negative regulation of cell proliferation involved in heart valve morphogenesis','P','Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve.','2013-10-27','NSRP'),(2552,3253,'cardiac neural crest cell migration involved in outflow tract morphogenesis','P','The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract.','2013-10-27','NSRP'),(2553,3254,'regulation of membrane depolarization','P','Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive.','2013-10-27','NSRP'),(2554,3255,'endocardial precursor cell differentiation','P','The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate.','2013-10-27','NSRP'),(2555,3256,'regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.','2013-10-27','NSRP'),(2556,3257,'positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell.','2013-10-27','NSRP'),(2557,3258,'regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell.','2013-10-27','NSRP'),(2558,3259,'cardioblast anterior-lateral migration','P','The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(2559,3260,'cardioblast migration','P','The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(2560,3261,'cardiac muscle progenitor cell migration to the midline involved in heart field formation','P','The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart.','2013-10-27','NSRP'),(2561,3262,'endocardial progenitor cell migration to the midline involved in heart field formation','P','The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart.','2013-10-27','NSRP'),(2562,3263,'cardioblast proliferation','P','The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(2563,3264,'regulation of cardioblast proliferation','P','Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(2564,3265,'regulation of primary heart field cardioblast proliferation','P','Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle.','2013-10-27','NSRP'),(2565,3266,'regulation of secondary heart field cardioblast proliferation','P','Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract).','2013-10-27','NSRP'),(2566,3267,'canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation','P','The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell resulting in an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(2567,3268,'fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation','P','The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(2568,3269,'BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation','P','A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(2569,3270,'Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation','P','The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(2570,3271,'smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation','P','The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(2571,3272,'endocardial cushion formation','P','The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.','2013-10-27','NSRP'),(2572,3273,'cell migration involved in endocardial cushion formation','P','The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.','2013-10-27','NSRP'),(2573,3274,'endocardial cushion fusion','P','The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping.','2013-10-27','NSRP'),(2574,3275,'apoptotic process involved in outflow tract morphogenesis','P','Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries.','2013-10-27','NSRP'),(2575,3276,'apoptotic process involved in heart valve morphogenesis','P','Any apoptotic process that contributes to the shaping of a heart valve.','2013-10-27','NSRP'),(2576,3277,'apoptotic process involved in endocardial cushion morphogenesis','P','Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.','2013-10-27','NSRP'),(2577,3278,'apoptotic process involved in heart morphogenesis','P','Any apoptotic process that contributes to the shaping of the heart.','2013-10-27','NSRP'),(2578,3279,'cardiac septum development','P','The progression of a cardiac septum over time, from its initial formation to the mature structure.','2013-10-27','NSRP'),(2579,3281,'ventricular septum development','P','The progression of the ventricular septum over time from its formation to the mature structure.','2013-10-27','NSRP'),(2580,3282,'ventricular septum intermedium development','P','The progression of the ventricular septum intermedium over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2581,3283,'atrial septum development','P','The progression of the atrial septum over time, from its initial formation to the mature structure.','2013-10-27','NSRP'),(2582,3284,'septum primum development','P','The progression of the septum primum over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2583,3285,'septum secundum development','P','The progression of the septum secundum over time, from its initial formation to the mature structure.','2013-10-27','NSRP'),(2584,3286,'atrial septum intermedium development','P','The progression of the atrial septum intermedium over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2585,3288,'ventricular septum intermedium morphogenesis','P','The developmental process in which a ventricular septum intermedium is generated and organized.','2013-10-27','NSRP'),(2586,3289,'atrial septum primum morphogenesis','P','The process in which anatomical structure of an atrial septum primum is generated and organized.','2013-10-27','NSRP'),(2587,3290,'atrial septum secundum morphogenesis','P','The process in which anatomical structure of an atrial septum secundum is generated and organized.','2013-10-27','NSRP'),(2588,3291,'atrial septum intermedium morphogenesis','P','The process in which anatomical structure of an atrial septum intermedium is generated and organized.','2013-10-27','NSRP'),(2589,3292,'cardiac septum cell differentiation','P','The process in which an endocardial cushion cell becomes a cell of a cardiac septum.','2013-10-27','NSRP'),(2590,3293,'heart valve cell differentiation','P','The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve.','2013-10-27','NSRP'),(2591,3294,'atrial ventricular junction remodeling','P','The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle.','2013-10-27','NSRP'),(2592,3295,'cell proliferation involved in atrial ventricular junction remodeling','P','The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.','2013-10-27','NSRP'),(2593,3296,'apoptotic process involved in atrial ventricular junction remodeling','P','Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction.','2013-10-27','NSRP'),(2594,3297,'heart wedging','P','The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart.','2013-10-27','NSRP'),(2595,3298,'physiological muscle hypertrophy','P','The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.','2013-10-27','NSRP'),(2596,3299,'muscle hypertrophy in response to stress','P','The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis.','2013-10-27','NSRP'),(2597,3300,'cardiac muscle hypertrophy','P','The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.','2013-10-27','NSRP'),(2598,3301,'physiological cardiac muscle hypertrophy','P','The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.','2013-10-27','NSRP'),(2599,3302,'transforming growth factor beta receptor signaling pathway involved in heart jogging','P','A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging.','2013-10-27','NSRP'),(2600,3303,'BMP signaling pathway involved in heart jogging','P','A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging.','2013-10-27','NSRP'),(2601,3304,'myocardial epithelial involution involved in heart jogging','P','The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging.','2013-10-27','NSRP'),(2602,3305,'cell migration involved in heart jogging','P','The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging.','2013-10-27','NSRP'),(2603,3306,'Wnt receptor signaling pathway involved in heart development','P','The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.','2013-10-27','NSRP'),(2604,3307,'regulation of Wnt receptor signaling pathway involved in heart development','P','Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.','2013-10-27','NSRP'),(2605,3308,'negative regulation of Wnt receptor signaling pathway involved in heart development','P','Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.','2013-10-27','NSRP'),(2606,3309,'type B pancreatic cell differentiation','P','The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.','2013-10-27','NSRP'),(2607,3310,'pancreatic A cell differentiation','P','The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.','2013-10-27','NSRP'),(2608,3311,'pancreatic D cell differentiation','P','The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.','2013-10-27','NSRP'),(2609,3312,'pancreatic PP cell differentiation','P','The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.','2013-10-27','NSRP'),(2610,3313,'heart rudiment development','P','The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.','2013-10-27','NSRP'),(2611,3314,'heart rudiment morphogenesis','P','The process in which the anatomical structures of the heart rudiment are generated and organized.','2013-10-27','NSRP'),(2612,3315,'heart rudiment formation','P','The developmental process pertaining to the initial formation of the heart rudiment.','2013-10-27','NSRP'),(2613,3316,'establishment of myocardial progenitor cell apical/basal polarity','P','The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment.','2013-10-27','NSRP'),(2614,3317,'cardioblast cell midline fusion','P','The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment.','2013-10-27','NSRP'),(2615,3318,'cell migration to the midline involved in heart development','P','The orderly movement of a cell toward the midline that contributes to the progression of the heart over time.','2013-10-27','NSRP'),(2616,3319,'cardioblast migration to the midline involved in heart rudiment formation','P','The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment.','2013-10-27','NSRP'),(2617,3320,'heart rudiment involution','P','The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube.','2013-10-27','NSRP'),(2618,3321,'positive regulation of blood pressure by epinephrine-norepinephrine','P','Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine.','2013-10-27','NSRP'),(2619,3322,'pancreatic A cell development','P','The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.','2013-10-27','NSRP'),(2620,3323,'type B pancreatic cell development','P','The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.','2013-10-27','NSRP'),(2621,3324,'pancreatic D cell development','P','The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin.','2013-10-27','NSRP'),(2622,3325,'pancreatic PP cell development','P','The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.','2013-10-27','NSRP'),(2623,3326,'pancreatic A cell fate commitment','P','The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon.','2013-10-27','NSRP'),(2624,3327,'type B pancreatic cell fate commitment','P','The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.','2013-10-27','NSRP'),(2625,3328,'pancreatic D cell fate commitment','P','The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin.','2013-10-27','NSRP'),(2626,3329,'pancreatic PP cell fate commitment','P','The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.','2013-10-27','NSRP'),(2627,3330,'regulation of extracellular matrix constituent secretion','P','Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.','2013-10-27','NSRP'),(2628,3331,'positive regulation of extracellular matrix constituent secretion','P','Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.','2013-10-27','NSRP'),(2629,3332,'negative regulation of extracellular matrix constituent secretion','P','Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells.','2013-10-27','NSRP'),(2630,3333,'amino acid transmembrane transport','P','The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(2631,3334,'keratinocyte development','P','The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure.','2013-10-27','NSRP'),(2632,3335,'corneocyte development','P','The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis.','2013-10-27','NSRP'),(2633,3336,'corneocyte desquamation','P','The delamination process that results in the shedding of a corneocyte from the surface of the epidermis.','2013-10-27','NSRP'),(2634,3337,'mesenchymal to epithelial transition involved in metanephros morphogenesis','P','A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.','2013-10-27','NSRP'),(2635,3338,'metanephros morphogenesis','P','The process in which the anatomical structures of the metanephros are generated and organized.','2013-10-27','NSRP'),(2636,3339,'regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis','P','Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.','2013-10-27','NSRP'),(2637,3340,'negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis','P','Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros.','2013-10-27','NSRP'),(2638,3341,'cilium movement','P','The directed, self-propelled movement of a cilium.','2013-10-27','NSRP'),(2639,3342,'proepicardium development','P','The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum.','2013-10-27','NSRP'),(2640,3343,'septum transversum development','P','The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme.','2013-10-27','NSRP'),(2641,3344,'pericardium morphogenesis','P','The process in which the anatomical structure of the pericardium is generated and organized.','2013-10-27','NSRP'),(2642,3345,'proepicardium cell migration involved in pericardium morphogenesis','P','The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart.','2013-10-27','NSRP'),(2643,3346,'epicardium-derived cell migration to the myocardium','P','The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium.','2013-10-27','NSRP'),(2644,3347,'epicardial cell to mesenchymal cell transition','P','A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium.','2013-10-27','NSRP'),(2645,3348,'cardiac endothelial cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.','2013-10-27','NSRP'),(2646,3349,'epicardium-derived cardiac endothelial cell differentiation','P','The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell.','2013-10-27','NSRP'),(2647,3350,'pulmonary myocardium development','P','The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein.','2013-10-27','NSRP'),(2648,3351,'epithelial cilium movement','P','The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid.','2013-10-27','NSRP'),(2649,3352,'regulation of cilium movement','P','Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.','2013-10-27','NSRP'),(2650,3353,'positive regulation of cilium movement','P','Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.','2013-10-27','NSRP'),(2651,3354,'negative regulation of cilium movement','P','Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium.','2013-10-27','NSRP'),(2652,3355,'cilium movement involved in otolith formation','P','The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles.','2013-10-27','NSRP'),(2653,3356,'regulation of cilium beat frequency','P','Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium.','2013-10-27','NSRP'),(2654,3357,'noradrenergic neuron differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline.','2013-10-27','NSRP'),(2655,3358,'noradrenergic neuron development','P','The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.','2013-10-27','NSRP'),(2656,3359,'noradrenergic neuron fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron.','2013-10-27','NSRP'),(2657,3360,'brainstem development','P','The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord.','2013-10-27','NSRP'),(2658,3361,'noradrenergic neuron differentiation involved in brainstem development','P','The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem.','2013-10-27','NSRP'),(2659,3362,'noradrenergic neuron fate commitment involved in brainstem development','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem.','2013-10-27','NSRP'),(2660,3363,'lamellipodium assembly involved in ameboidal cell migration','P','Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell.','2013-10-27','NSRP'),(2661,3364,'lamellipodium assembly involved in mesendodermal cell migration','P','Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell.','2013-10-27','NSRP'),(2662,3365,'establishment of cell polarity involved in ameboidal cell migration','P','The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell.','2013-10-27','NSRP'),(2663,3366,'cell-matrix adhesion involved in ameboidal cell migration','P','The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.','2013-10-27','NSRP'),(2664,3367,'cell-cell adhesion involved in ameboidal cell migration','P','The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells.','2013-10-27','NSRP'),(2665,3368,'cell-matrix adhesion involved in mesendodermal cell migration','P','The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell.','2013-10-27','NSRP'),(2666,3369,'establishment of cell polarity involved in mesendodermal cell migration','P','The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell.','2013-10-27','NSRP'),(2667,3370,'cell-cell adhesion involved in mesendodermal cell migration','P','The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm.','2013-10-27','NSRP'),(2668,3371,'establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration','P','Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.','2013-10-27','NSRP'),(2669,3372,'establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration','P','Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell.','2013-10-27','NSRP'),(2670,3373,'dynamin polymerization involved in membrane fission','P','The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers. Dynamin polymers form around lipid tubes and contribute to membrane fission.','2013-10-27','NSRP'),(2671,3374,'dynamin polymerization involved in mitochondrial fission','P','The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission.','2013-10-27','NSRP'),(2672,3375,'regulation of dynamin polymerization involved in membrane fission','P','Any process that modulates the rate, frequency, or extent of membrane fission.','2013-10-27','NSRP'),(2673,3376,'sphingosine-1-phosphate signaling pathway','P','A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(2674,3377,'regulation of apoptosis by sphingosine-1-phosphate signaling pathway','P','A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis.','2013-10-27','NSRP'),(2675,3378,'regulation of inflammatory response by sphingosine-1-phosphate signaling pathway','P','A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response.','2013-10-27','NSRP'),(2676,3379,'establishment of cell polarity involved in gastrulation cell migration','P','The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation.','2013-10-27','NSRP'),(2677,3380,'establishment or maintenance of cytoskeleton polarity involved in gastrulation','P','Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation.','2013-10-27','NSRP'),(2678,3381,'epithelial cell morphogenesis involved in gastrulation','P','The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation.','2013-10-27','NSRP'),(2679,3382,'epithelial cell morphogenesis','P','The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.','2013-10-27','NSRP'),(2680,3383,'apical constriction','P','The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.','2013-10-27','NSRP'),(2681,3384,'apical constriction involved in gastrulation','P','The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation.','2013-10-27','NSRP'),(2682,3385,'cell-cell signaling involved in amphid sensory organ development','P','Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state.','2013-10-27','NSRP'),(2683,3386,'amphid sensory organ development','P','The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes.','2013-10-27','NSRP'),(2684,3387,'neuron differentiation involved in amphid sensory organ development','P','The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland.','2013-10-27','NSRP'),(2685,3388,'neuron development involved in amphid sensory organ development','P','The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ.','2013-10-27','NSRP'),(2686,3389,'retrograde extension','P','The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point.','2013-10-27','NSRP'),(2687,3390,'dendrite development by retrograde extension','P','The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point.','2013-10-27','NSRP'),(2688,3391,'amphid sensory organ dendrite retrograde extension','P','The progression of an amphid sensory organ\'s neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point.','2013-10-27','NSRP'),(2689,3392,'cell adhesion involved in retrograde extension','P','The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension.','2013-10-27','NSRP'),(2690,3393,'neuron migration involved in retrograde extension','P','The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension.','2013-10-27','NSRP'),(2691,3394,'cell adhesion involved in dendrite retrograde extension','P','The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite.','2013-10-27','NSRP'),(2692,3395,'neuron migration involved in dendrite retrograde extension','P','The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite.','2013-10-27','NSRP'),(2693,3396,'cell adhesion involved in amphid sensory organ dendrite retrograde extension','P','The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ.','2013-10-27','NSRP'),(2694,3397,'neuron migration involved in amphid sensory organ dendrite retrograde extension','P','The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ.','2013-10-27','NSRP'),(2695,3398,'glial cell differentiation involved in amphid sensory organ development','P','The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ.','2013-10-27','NSRP'),(2696,3399,'cytoneme morphogenesis','P','The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell.','2013-10-27','NSRP'),(2697,3400,'regulation of COPII vesicle coating','P','Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat.','2013-10-27','NSRP'),(2698,3401,'axis elongation','P','The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.','2013-10-27','NSRP'),(2699,3402,'planar cell polarity pathway involved in axis elongation','P','The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation.','2013-10-27','NSRP'),(2700,3403,'optic vesicle formation','P','The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.','2013-10-27','NSRP'),(2701,3404,'optic vesicle morphogenesis','P','The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.','2013-10-27','NSRP'),(2702,3405,'optic vesicle elongation','P','The developmental growth that results in the lengthening of the optic vesicle in the posterior direction.','2013-10-27','NSRP'),(2703,3406,'retinal pigment epithelium development','P','The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.','2013-10-27','NSRP'),(2704,3407,'neural retina development','P','The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.','2013-10-27','NSRP'),(2705,3408,'optic cup formation involved in camera-type eye development','P','The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle.','2013-10-27','NSRP'),(2706,3409,'optic cup structural organization','P','The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure.','2013-10-27','NSRP'),(2707,3410,'anterior rotation of the optic cup','P','A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis.','2013-10-27','NSRP'),(2708,3411,'cell motility involved in camera-type eye morphogenesis','P','Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.','2013-10-27','NSRP'),(2709,3412,'establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis','P','The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye.','2013-10-27','NSRP'),(2710,3413,'chondrocyte differentiation involved in endochondral bone morphogenesis','P','The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.','2013-10-27','NSRP'),(2711,3414,'chondrocyte morphogenesis involved in endochondral bone morphogenesis','P','The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.','2013-10-27','NSRP'),(2712,3415,'chondrocyte hypertrophy','P','The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time.','2013-10-27','NSRP'),(2713,3416,'endochondral bone growth','P','The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.','2013-10-27','NSRP'),(2714,3417,'growth plate cartilage development','P','The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow.','2013-10-27','NSRP'),(2715,3418,'growth plate cartilage chondrocyte differentiation','P','The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.','2013-10-27','NSRP'),(2716,3419,'growth plate cartilage chondrocyte proliferation','P','The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(2717,3420,'regulation of growth plate cartilage chondrocyte proliferation','P','Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(2718,3421,'growth plate cartilage axis specification','P','The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth.','2013-10-27','NSRP'),(2719,3422,'growth plate cartilage morphogenesis','P','The process in which the anatomical structures of cartilage are generated and organized.','2013-10-27','NSRP'),(2720,3423,'growth plate cartilage chondrocyte division','P','The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate.','2013-10-27','NSRP'),(2721,3424,'establishment of cell polarity involved in growth plate cartilage chondrocyte division','P','The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte.','2013-10-27','NSRP'),(2722,3425,'establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division','P','A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate.','2013-10-27','NSRP'),(2723,3426,'cytoskeleton polarization involved in growth plate cartilage chondrocyte division','P','A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell.','2013-10-27','NSRP'),(2724,3427,'regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division','P','The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell.','2013-10-27','NSRP'),(2725,3428,'chondrocyte intercalation involved in growth plate cartilage morphogenesis','P','The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone.','2013-10-27','NSRP'),(2726,3429,'growth plate cartilage chondrocyte morphogenesis','P','The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized.','2013-10-27','NSRP'),(2727,3430,'growth plate cartilage chondrocyte growth','P','The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another.','2013-10-27','NSRP'),(2728,3431,'growth plate cartilage chondrocyte development','P','The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell.','2013-10-27','NSRP'),(2729,3432,'cell growth involved in growth plate cartilage chondrocyte morphogenesis','P','The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time.','2013-10-27','NSRP'),(2730,3433,'chondrocyte development involved in endochondral bone morphogenesis','P','The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.','2013-10-27','NSRP'),(2731,3434,'BMP signaling pathway involved in growth plate cartilage chondrocyte development','P','A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time.','2013-10-27','NSRP'),(2732,3435,'smoothened signaling pathway involved in growth plate cartilage chondrocyte development','P','The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time.','2013-10-27','NSRP'),(2733,3436,'regulation of cell adhesion involved in growth plate cartilage morphogenesis','P','Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone.','2013-10-27','NSRP'),(2734,3437,'regulation of cell communication involved in growth plate cartilage morphogenesis','P','Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage.','2013-10-27','NSRP'),(2735,3673,'Gene_Ontology','P','OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes.','2013-10-27','NSRP'),(2736,3674,'molecular_function','F','Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions.','2013-10-27','NSRP'),(2737,3675,'protein','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2738,3676,'nucleic acid binding','F','Interacting selectively and non-covalently with any nucleic acid.','2013-10-27','NSRP'),(2739,3677,'DNA binding','F','Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).','2013-10-27','NSRP'),(2740,3678,'DNA helicase activity','F','Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.','2013-10-27','NSRP'),(2741,3680,'AT DNA binding','F','Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).','2013-10-27','NSRP'),(2742,3681,'bent DNA binding','F','Interacting selectively and non-covalently with DNA in a bent conformation.','2013-10-27','NSRP'),(2743,3682,'chromatin binding','F','Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.','2013-10-27','NSRP'),(2744,3683,'lamin/chromatin binding','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2745,3684,'damaged DNA binding','F','Interacting selectively and non-covalently with damaged DNA.','2013-10-27','NSRP'),(2746,3685,'DNA repair protein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2747,3686,'DNA repair enzyme','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2748,3687,'DNA replication factor','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2749,3688,'DNA replication origin binding','F','Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally.','2013-10-27','NSRP'),(2750,3689,'DNA clamp loader activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex.','2013-10-27','NSRP'),(2751,3690,'double-stranded DNA binding','F','Interacting selectively and non-covalently with double-stranded DNA.','2013-10-27','NSRP'),(2752,3691,'double-stranded telomeric DNA binding','F','Interacting selectively and non-covalently with double-stranded telomere-associated DNA.','2013-10-27','NSRP'),(2753,3692,'left-handed Z-DNA binding','F','Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags.','2013-10-27','NSRP'),(2754,3693,'P-element binding','F','Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis.','2013-10-27','NSRP'),(2755,3694,'plasmid binding','F','OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms.','2013-10-27','NSRP'),(2756,3695,'random coil DNA binding','F','Interacting selectively and non-covalently with DNA in a random coil configuration.','2013-10-27','NSRP'),(2757,3696,'satellite DNA binding','F','Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA.','2013-10-27','NSRP'),(2758,3697,'single-stranded DNA binding','F','Interacting selectively and non-covalently with single-stranded DNA.','2013-10-27','NSRP'),(2759,3700,'sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex.','2013-10-27','NSRP'),(2760,3701,'RNA polymerase I transcription factor activity','F','OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription.','2013-10-27','NSRP'),(2761,3702,'RNA polymerase II transcription factor activity','F','OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription.','2013-10-27','NSRP'),(2762,3704,'specific RNA polymerase II transcription factor activity','F','OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II.','2013-10-27','NSRP'),(2763,3705,'RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity','F','Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II.','2013-10-27','NSRP'),(2764,3706,'ligand-regulated transcription factor activity','F','OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand.','2013-10-27','NSRP'),(2765,3707,'steroid hormone receptor activity','F','Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.','2013-10-27','NSRP'),(2766,3708,'retinoic acid receptor activity','F','Combining with retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. Retinoic acid is one of the forms of vitamin A.','2013-10-27','NSRP'),(2767,3709,'RNA polymerase III transcription factor activity','F','OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription.','2013-10-27','NSRP'),(2768,3711,'transcription elongation regulator activity','F','OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation.','2013-10-27','NSRP'),(2769,3712,'transcription cofactor activity','F','Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.','2013-10-27','NSRP'),(2770,3713,'transcription coactivator activity','F','Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.','2013-10-27','NSRP'),(2771,3714,'transcription corepressor activity','F','Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery.','2013-10-27','NSRP'),(2772,3715,'transcription termination factor activity','F','OBSOLETE. Any activity that brings about termination of transcription.','2013-10-27','NSRP'),(2773,3716,'RNA polymerase I transcription termination factor activity','F','OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I.','2013-10-27','NSRP'),(2774,3717,'RNA polymerase II transcription termination factor activity','F','OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II.','2013-10-27','NSRP'),(2775,3718,'RNA polymerase III transcription termination factor activity','F','OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III.','2013-10-27','NSRP'),(2776,3719,'transcription factor binding, cytoplasmic sequestering','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2777,3720,'telomerase activity','F','Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3\'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.','2013-10-27','NSRP'),(2778,3721,'telomeric template RNA reverse transcriptase activity','F','Catalysis of the extension of the 3\' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template.','2013-10-27','NSRP'),(2779,3723,'RNA binding','F','Interacting selectively and non-covalently with an RNA molecule or a portion thereof.','2013-10-27','NSRP'),(2780,3724,'RNA helicase activity','F','Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix.','2013-10-27','NSRP'),(2781,3725,'double-stranded RNA binding','F','Interacting selectively and non-covalently with double-stranded RNA.','2013-10-27','NSRP'),(2782,3726,'double-stranded RNA adenosine deaminase activity','F','Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule.','2013-10-27','NSRP'),(2783,3727,'single-stranded RNA binding','F','Interacting selectively and non-covalently with single-stranded RNA.','2013-10-27','NSRP'),(2784,3729,'mRNA binding','F','Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.','2013-10-27','NSRP'),(2785,3730,'mRNA 3\'-UTR binding','F','Interacting selectively and non-covalently with the 3\' untranslated region of an mRNA molecule.','2013-10-27','NSRP'),(2786,3731,'mRNA cap binding','F','OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5\' end of a nascent messenger RNA transcript.','2013-10-27','NSRP'),(2787,3732,'snRNA cap binding','F','OBSOLETE. Interacting selectively with the cap structure at the 5\' end of a small nuclear RNA molecule.','2013-10-27','NSRP'),(2788,3733,'ribonucleoprotein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2789,3734,'small nuclear ribonucleoprotein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2790,3735,'structural constituent of ribosome','F','The action of a molecule that contributes to the structural integrity of the ribosome.','2013-10-27','NSRP'),(2791,3743,'translation initiation factor activity','F','Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.','2013-10-27','NSRP'),(2792,3746,'translation elongation factor activity','F','Functions in chain elongation during polypeptide synthesis at the ribosome.','2013-10-27','NSRP'),(2793,3747,'translation release factor activity','F','Involved in catalyzing the release of a nascent polypeptide chain from a ribosome.','2013-10-27','NSRP'),(2794,3750,'cell cycle regulator','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2795,3754,'chaperone activity','F','OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function.','2013-10-27','NSRP'),(2796,3755,'peptidyl-prolyl cis-trans isomerase activity','F','Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).','2013-10-27','NSRP'),(2797,3756,'protein disulfide isomerase activity','F','Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins.','2013-10-27','NSRP'),(2798,3759,'glycoprotein-specific chaperone activity','F','OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins.','2013-10-27','NSRP'),(2799,3762,'histone-specific chaperone activity','F','OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function.','2013-10-27','NSRP'),(2800,3763,'chaperonin ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts.','2013-10-27','NSRP'),(2801,3767,'co-chaperone activity','F','OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity.','2013-10-27','NSRP'),(2802,3772,'co-chaperonin activity','F','OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity.','2013-10-27','NSRP'),(2803,3773,'heat shock protein activity','F','OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones.','2013-10-27','NSRP'),(2804,3774,'motor activity','F','Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate.','2013-10-27','NSRP'),(2805,3775,'axonemal motor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2806,3776,'muscle motor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2807,3777,'microtubule motor activity','F','Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).','2013-10-27','NSRP'),(2808,3778,'dynactin motor','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2809,3779,'actin binding','F','Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.','2013-10-27','NSRP'),(2810,3780,'actin cross-linking activity','F','OBSOLETE. Interacting selectively with two actin filaments to anchor them together.','2013-10-27','NSRP'),(2811,3781,'actin bundling activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2812,3782,'F-actin capping activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2813,3783,'barbed-end actin capping activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2814,3784,'barbed-end actin capping/severing activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2815,3785,'actin monomer binding','F','Interacting selectively and non-covalently with monomeric actin, also known as G-actin.','2013-10-27','NSRP'),(2816,3786,'actin lateral binding','F','Interacting selectively and non-covalently with an actin filament along its length.','2013-10-27','NSRP'),(2817,3787,'actin depolymerizing activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2818,3788,'actin monomer sequestering activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2819,3789,'actin filament severing activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2820,3790,'actin modulating activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2821,3791,'membrane associated actin binding','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2822,3792,'regulation of actin thin filament length activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2823,3793,'defense/immunity protein activity','F','OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease.','2013-10-27','NSRP'),(2824,3794,'acute-phase response protein activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2825,3795,'antimicrobial peptide activity','F','OBSOLETE. Inhibits the growth of, or directly kills, microbial cells.','2013-10-27','NSRP'),(2826,3796,'lysozyme activity','F','Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.','2013-10-27','NSRP'),(2827,3797,'antibacterial peptide activity','F','OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells.','2013-10-27','NSRP'),(2828,3798,'male-specific antibacterial peptide activity','F','OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males.','2013-10-27','NSRP'),(2829,3799,'antifungal peptide activity','F','OBSOLETE. Inhibits the growth of, or directly kills, fungal cells.','2013-10-27','NSRP'),(2830,3800,'antiviral response protein activity','F','OBSOLETE. A protein involved in an antiviral response.','2013-10-27','NSRP'),(2831,3801,'blood coagulation factor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2832,3802,'coagulation factor VIIa activity','F','OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta.','2013-10-27','NSRP'),(2833,3803,'coagulation factor IXa activity','F','OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa.','2013-10-27','NSRP'),(2834,3804,'coagulation factor Xa activity','F','OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa).','2013-10-27','NSRP'),(2835,3805,'coagulation factor XIa activity','F','OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa.','2013-10-27','NSRP'),(2836,3806,'coagulation factor XIIa activity','F','OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.','2013-10-27','NSRP'),(2837,3807,'plasma kallikrein activity','F','OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin.','2013-10-27','NSRP'),(2838,3808,'protein C (activated) activity','F','OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa.','2013-10-27','NSRP'),(2839,3809,'thrombin activity','F','OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.','2013-10-27','NSRP'),(2840,3810,'protein-glutamine gamma-glutamyltransferase activity','F','Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links.','2013-10-27','NSRP'),(2841,3811,'complement activity','F','OBSOLETE. Any of a set of activities involved in the complement cascade.','2013-10-27','NSRP'),(2842,3812,'alternative-complement-pathway C3/C5 convertase activity','F','OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b.','2013-10-27','NSRP'),(2843,3813,'classical-complement-pathway C3/C5 convertase activity','F','OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b.','2013-10-27','NSRP'),(2844,3815,'complement component C1r activity','F','OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42).','2013-10-27','NSRP'),(2845,3816,'complement component C1s activity','F','OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond).','2013-10-27','NSRP'),(2846,3817,'complement factor D activity','F','OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF).','2013-10-27','NSRP'),(2847,3818,'complement factor I activity','F','OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage.','2013-10-27','NSRP'),(2848,3819,'major histocompatibility complex antigen','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2849,3820,'class I major histocompatibility complex antigen','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2850,3821,'class II major histocompatibility complex antigen','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2851,3822,'MHC-interacting protein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2852,3823,'antigen binding','F','Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.','2013-10-27','NSRP'),(2853,3824,'catalytic activity','F','Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.','2013-10-27','NSRP'),(2854,3825,'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity','F','Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate.','2013-10-27','NSRP'),(2855,3826,'alpha-ketoacid dehydrogenase activity','F','Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid.','2013-10-27','NSRP'),(2856,3827,'alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP.','2013-10-27','NSRP'),(2857,3828,'alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity','F','Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.','2013-10-27','NSRP'),(2858,3829,'beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R.','2013-10-27','NSRP'),(2859,3830,'beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R.','2013-10-27','NSRP'),(2860,3831,'beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity','F','Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide.','2013-10-27','NSRP'),(2861,3832,'beta-alanyl-dopamine hydrolase activity','F','Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine.','2013-10-27','NSRP'),(2862,3833,'beta-alanyl-dopamine synthase activity','F','Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine).','2013-10-27','NSRP'),(2863,3834,'beta-carotene 15,15\'-monooxygenase activity','F','Catalysis of the reaction: beta-carotene + O(2) = 2 retinal.','2013-10-27','NSRP'),(2864,3835,'beta-galactoside alpha-2,6-sialyltransferase activity','F','Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine.','2013-10-27','NSRP'),(2865,3836,'beta-galactoside (CMP) alpha-2,3-sialyltransferase activity','F','Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.','2013-10-27','NSRP'),(2866,3837,'beta-ureidopropionase activity','F','Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3.','2013-10-27','NSRP'),(2867,3838,'sterol 24-C-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.','2013-10-27','NSRP'),(2868,3839,'gamma-glutamylcyclotransferase activity','F','Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.','2013-10-27','NSRP'),(2869,3840,'gamma-glutamyltransferase activity','F','Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid.','2013-10-27','NSRP'),(2870,3841,'1-acylglycerol-3-phosphate O-acyltransferase activity','F','Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate.','2013-10-27','NSRP'),(2871,3842,'1-pyrroline-5-carboxylate dehydrogenase activity','F','Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).','2013-10-27','NSRP'),(2872,3843,'1,3-beta-D-glucan synthase activity','F','Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1).','2013-10-27','NSRP'),(2873,3844,'1,4-alpha-glucan branching enzyme activity','F','Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain.','2013-10-27','NSRP'),(2874,3845,'11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity','F','Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+).','2013-10-27','NSRP'),(2875,3846,'2-acylglycerol O-acyltransferase activity','F','Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol.','2013-10-27','NSRP'),(2876,3847,'1-alkyl-2-acetylglycerophosphocholine esterase activity','F','Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.','2013-10-27','NSRP'),(2877,3848,'2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity','F','Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+).','2013-10-27','NSRP'),(2878,3849,'3-deoxy-7-phosphoheptulonate synthase activity','F','Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate.','2013-10-27','NSRP'),(2879,3850,'2-deoxyglucose-6-phosphatase activity','F','Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate.','2013-10-27','NSRP'),(2880,3851,'2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity','F','Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine.','2013-10-27','NSRP'),(2881,3852,'2-isopropylmalate synthase activity','F','Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+).','2013-10-27','NSRP'),(2882,3853,'2-methylacyl-CoA dehydrogenase activity','F','Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor.','2013-10-27','NSRP'),(2883,3854,'3-beta-hydroxy-delta5-steroid dehydrogenase activity','F','Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+).','2013-10-27','NSRP'),(2884,3855,'3-dehydroquinate dehydratase activity','F','Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.','2013-10-27','NSRP'),(2885,3856,'3-dehydroquinate synthase activity','F','Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate.','2013-10-27','NSRP'),(2886,3857,'3-hydroxyacyl-CoA dehydrogenase activity','F','Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+).','2013-10-27','NSRP'),(2887,3858,'3-hydroxybutyrate dehydrogenase activity','F','Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH.','2013-10-27','NSRP'),(2888,3859,'3-hydroxybutyryl-CoA dehydratase activity','F','Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O.','2013-10-27','NSRP'),(2889,3860,'3-hydroxyisobutyryl-CoA hydrolase activity','F','Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.','2013-10-27','NSRP'),(2890,3861,'3-isopropylmalate dehydratase activity','F','Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O.','2013-10-27','NSRP'),(2891,3862,'3-isopropylmalate dehydrogenase activity','F','Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.','2013-10-27','NSRP'),(2892,3863,'3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity','F','Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2.','2013-10-27','NSRP'),(2893,3864,'3-methyl-2-oxobutanoate hydroxymethyltransferase activity','F','Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate.','2013-10-27','NSRP'),(2894,3865,'3-oxo-5-alpha-steroid 4-dehydrogenase activity','F','Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor.','2013-10-27','NSRP'),(2895,3866,'3-phosphoshikimate 1-carboxyvinyltransferase activity','F','Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate.','2013-10-27','NSRP'),(2896,3867,'4-aminobutyrate transaminase activity','F','Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid.','2013-10-27','NSRP'),(2897,3868,'4-hydroxyphenylpyruvate dioxygenase activity','F','Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.','2013-10-27','NSRP'),(2898,3869,'4-nitrophenylphosphatase activity','F','Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate.','2013-10-27','NSRP'),(2899,3870,'5-aminolevulinate synthase activity','F','Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA.','2013-10-27','NSRP'),(2900,3871,'5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity','F','Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.','2013-10-27','NSRP'),(2901,3872,'6-phosphofructokinase activity','F','Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate.','2013-10-27','NSRP'),(2902,3873,'6-phosphofructo-2-kinase activity','F','Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(2903,3874,'6-pyruvoyltetrahydropterin synthase activity','F','Catalysis of the reaction: 7,8-dihydroneopterin 3\'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate.','2013-10-27','NSRP'),(2904,3875,'ADP-ribosylarginine hydrolase activity','F','Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose.','2013-10-27','NSRP'),(2905,3876,'AMP deaminase activity','F','Catalysis of the reaction: AMP + H2O = IMP + NH3.','2013-10-27','NSRP'),(2906,3877,'ATP adenylyltransferase activity','F','Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5\'-adenosyl)tetraphosphate.','2013-10-27','NSRP'),(2907,3878,'ATP citrate synthase activity','F','Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA.','2013-10-27','NSRP'),(2908,3879,'ATP phosphoribosyltransferase activity','F','Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.','2013-10-27','NSRP'),(2909,3880,'protein C-terminal carboxyl O-methyltransferase activity','F','Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein.','2013-10-27','NSRP'),(2910,3881,'CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity','F','Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+).','2013-10-27','NSRP'),(2911,3882,'CDP-diacylglycerol-serine O-phosphatidyltransferase activity','F','Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine.','2013-10-27','NSRP'),(2912,3883,'CTP synthase activity','F','Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP.','2013-10-27','NSRP'),(2913,3884,'D-amino-acid oxidase activity','F','Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide.','2013-10-27','NSRP'),(2914,3885,'D-arabinono-1,4-lactone oxidase activity','F','Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+).','2013-10-27','NSRP'),(2915,3886,'DNA (cytosine-5-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.','2013-10-27','NSRP'),(2916,3887,'DNA-directed DNA polymerase activity','F','Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer.','2013-10-27','NSRP'),(2917,3892,'proliferating cell nuclear antigen','F','OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair.','2013-10-27','NSRP'),(2918,3896,'DNA primase activity','F','Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3\'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase.','2013-10-27','NSRP'),(2919,3899,'DNA-directed RNA polymerase activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3\'-end of an RNA strand by one nucleotide at a time. Can initiate a chain \'de novo\'.','2013-10-27','NSRP'),(2920,3900,'DNA-directed RNA polymerase I activity','F','OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).','2013-10-27','NSRP'),(2921,3901,'DNA-directed RNA polymerase II activity','F','OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).','2013-10-27','NSRP'),(2922,3902,'DNA-directed RNA polymerase III activity','F','OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).','2013-10-27','NSRP'),(2923,3904,'deoxyribodipyrimidine photo-lyase activity','F','Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light.','2013-10-27','NSRP'),(2924,3905,'alkylbase DNA N-glycosylase activity','F','Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1\' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site.','2013-10-27','NSRP'),(2925,3906,'DNA-(apurinic or apyrimidinic site) lyase activity','F','Catalysis of the cleavage of the C-O-P bond 3\' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3\'-terminal unsaturated sugar and a product with a terminal 5\'-phosphate.','2013-10-27','NSRP'),(2926,3908,'methylated-DNA-[protein]-cysteine S-methyltransferase activity','F','Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.','2013-10-27','NSRP'),(2927,3909,'DNA ligase activity','F','Catalysis of the formation of a phosphodiester bond between the 3\'-hydroxyl group at the end of one DNA chain and the 5\'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+.','2013-10-27','NSRP'),(2928,3910,'DNA ligase (ATP) activity','F','Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m).','2013-10-27','NSRP'),(2929,3911,'DNA ligase (NAD+) activity','F','Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).','2013-10-27','NSRP'),(2930,3912,'DNA nucleotidylexotransferase activity','F','Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).','2013-10-27','NSRP'),(2931,3913,'DNA photolyase activity','F','Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA.','2013-10-27','NSRP'),(2932,3914,'DNA (6-4) photolyase activity','F','Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA.','2013-10-27','NSRP'),(2933,3916,'DNA topoisomerase activity','F','Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA.','2013-10-27','NSRP'),(2934,3917,'DNA topoisomerase type I activity','F','Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle.','2013-10-27','NSRP'),(2935,3918,'DNA topoisomerase type II (ATP-hydrolyzing) activity','F','Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.','2013-10-27','NSRP'),(2936,3919,'FMN adenylyltransferase activity','F','Catalysis of the reaction: ATP + FMN = diphosphate + FAD.','2013-10-27','NSRP'),(2937,3920,'GMP reductase activity','F','Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH.','2013-10-27','NSRP'),(2938,3921,'GMP synthase activity','F','Catalysis of the reaction: ATP + xanthosine 5\'-phosphate + NH3 = AMP + diphosphate + GMP.','2013-10-27','NSRP'),(2939,3922,'GMP synthase (glutamine-hydrolyzing) activity','F','Catalysis of the reaction: ATP + xanthosine 5\'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.','2013-10-27','NSRP'),(2940,3923,'GPI-anchor transamidase activity','F','Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor.','2013-10-27','NSRP'),(2941,3924,'GTPase activity','F','Catalysis of the reaction: GTP + H2O = GDP + phosphate.','2013-10-27','NSRP'),(2942,3925,'small monomeric GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).','2013-10-27','NSRP'),(2943,3926,'ARF small monomeric GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.','2013-10-27','NSRP'),(2944,3927,'heterotrimeric G-protein GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase.','2013-10-27','NSRP'),(2945,3928,'RAB small monomeric GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.','2013-10-27','NSRP'),(2946,3929,'RAN small monomeric GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.','2013-10-27','NSRP'),(2947,3930,'RAS small monomeric GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.','2013-10-27','NSRP'),(2948,3931,'Rho small monomeric GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.','2013-10-27','NSRP'),(2949,3932,'SAR small monomeric GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.','2013-10-27','NSRP'),(2950,3933,'GTP cyclohydrolase activity','F','Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized.','2013-10-27','NSRP'),(2951,3934,'GTP cyclohydrolase I activity','F','Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3\'-triphosphate.','2013-10-27','NSRP'),(2952,3935,'GTP cyclohydrolase II activity','F','Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+).','2013-10-27','NSRP'),(2953,3936,'hydrogen-transporting two-sector ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out).','2013-10-27','NSRP'),(2954,3937,'IMP cyclohydrolase activity','F','Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide.','2013-10-27','NSRP'),(2955,3938,'IMP dehydrogenase activity','F','Catalysis of the reaction: inosine 5\'-phosphate + NAD+ + H2O = xanthosine 5\'-phosphate + NADH + H+.','2013-10-27','NSRP'),(2956,3939,'L-iditol 2-dehydrogenase activity','F','Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+.','2013-10-27','NSRP'),(2957,3940,'L-iduronidase activity','F','Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate.','2013-10-27','NSRP'),(2958,3941,'L-serine ammonia-lyase activity','F','Catalysis of the reaction: L-serine = pyruvate + NH3.','2013-10-27','NSRP'),(2959,3942,'N-acetyl-gamma-glutamyl-phosphate reductase activity','F','Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.','2013-10-27','NSRP'),(2960,3943,'N-acetylgalactosamine-4-sulfatase activity','F','Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate.','2013-10-27','NSRP'),(2961,3944,'N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity','F','Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose.','2013-10-27','NSRP'),(2962,3945,'N-acetyllactosamine synthase activity','F','Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine.','2013-10-27','NSRP'),(2963,3947,'(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide.','2013-10-27','NSRP'),(2964,3948,'N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity','F','Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+).','2013-10-27','NSRP'),(2965,3949,'1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity','F','Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.','2013-10-27','NSRP'),(2966,3950,'NAD+ ADP-ribosyltransferase activity','F','Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.','2013-10-27','NSRP'),(2967,3951,'NAD+ kinase activity','F','Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+).','2013-10-27','NSRP'),(2968,3952,'NAD+ synthase (glutamine-hydrolyzing) activity','F','Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate.','2013-10-27','NSRP'),(2969,3953,'NAD+ nucleosidase activity','F','Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose.','2013-10-27','NSRP'),(2970,3954,'NADH dehydrogenase activity','F','Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor.','2013-10-27','NSRP'),(2971,3955,'NAD(P)H dehydrogenase (quinone) activity','F','Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone.','2013-10-27','NSRP'),(2972,3956,'NAD(P)+-protein-arginine ADP-ribosyltransferase activity','F','Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine.','2013-10-27','NSRP'),(2973,3957,'NAD(P)+ transhydrogenase (B-specific) activity','F','Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+.','2013-10-27','NSRP'),(2974,3958,'NADPH-hemoprotein reductase activity','F','Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein.','2013-10-27','NSRP'),(2975,3959,'NADPH dehydrogenase activity','F','Catalysis of the reaction: NADPH + H+ + quinone acceptor = NADP+ + hydroquinone.','2013-10-27','NSRP'),(2976,3960,'NADPH:quinone reductase activity','F','Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone.','2013-10-27','NSRP'),(2977,3961,'O-acetylhomoserine aminocarboxypropyltransferase activity','F','Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers.','2013-10-27','NSRP'),(2978,3962,'cystathionine gamma-synthase activity','F','Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate.','2013-10-27','NSRP'),(2979,3963,'RNA-3\'-phosphate cyclase activity','F','Catalysis of the reaction: ATP + RNA 3\'-terminal-phosphate = AMP + diphosphate + RNA terminal-2\',3\'-cyclic-phosphate.','2013-10-27','NSRP'),(2980,3964,'RNA-directed DNA polymerase activity','F','Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3\'- end of a DNA strand by one deoxynucleotide at a time.','2013-10-27','NSRP'),(2981,3966,'RNA-directed DNA polymerase, transposon encoded','F','OBSOLETE. Catalysis of RNA-template-directed extension of the 3\'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo.','2013-10-27','NSRP'),(2982,3967,'RNA-directed DNA polymerase, group II intron encoded','F','OBSOLETE. Catalysis of RNA-template-directed extension of the 3\'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo.','2013-10-27','NSRP'),(2983,3968,'RNA-directed RNA polymerase activity','F','Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template.','2013-10-27','NSRP'),(2984,3969,'RNA editase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(2985,3972,'RNA ligase (ATP) activity','F','Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m).','2013-10-27','NSRP'),(2986,3973,'(S)-2-hydroxy-acid oxidase activity','F','Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide.','2013-10-27','NSRP'),(2987,3974,'UDP-N-acetylglucosamine 4-epimerase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine.','2013-10-27','NSRP'),(2988,3975,'UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.','2013-10-27','NSRP'),(2989,3976,'UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose.','2013-10-27','NSRP'),(2990,3977,'UDP-N-acetylglucosamine diphosphorylase activity','F','Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine.','2013-10-27','NSRP'),(2991,3978,'UDP-glucose 4-epimerase activity','F','Catalysis of the reaction: UDP-glucose = UDP-galactose.','2013-10-27','NSRP'),(2992,3979,'UDP-glucose 6-dehydrogenase activity','F','Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.','2013-10-27','NSRP'),(2993,3980,'UDP-glucose:glycoprotein glucosyltransferase activity','F','Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins.','2013-10-27','NSRP'),(2994,3983,'UTP:glucose-1-phosphate uridylyltransferase activity','F','Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose.','2013-10-27','NSRP'),(2995,3984,'acetolactate synthase activity','F','Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2.','2013-10-27','NSRP'),(2996,3985,'acetyl-CoA C-acetyltransferase activity','F','Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA.','2013-10-27','NSRP'),(2997,3986,'acetyl-CoA hydrolase activity','F','Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).','2013-10-27','NSRP'),(2998,3987,'acetate-CoA ligase activity','F','Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.','2013-10-27','NSRP'),(2999,3988,'acetyl-CoA C-acyltransferase activity','F','Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.','2013-10-27','NSRP'),(3000,3989,'acetyl-CoA carboxylase activity','F','Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.','2013-10-27','NSRP'),(3001,3990,'acetylcholinesterase activity','F','Catalysis of the reaction: acetylcholine + H2O = choline + acetate.','2013-10-27','NSRP'),(3002,3991,'acetylglutamate kinase activity','F','Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate.','2013-10-27','NSRP'),(3003,3992,'N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity','F','Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.','2013-10-27','NSRP'),(3004,3993,'acid phosphatase activity','F','Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.','2013-10-27','NSRP'),(3005,3994,'aconitate hydratase activity','F','Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.','2013-10-27','NSRP'),(3006,3995,'acyl-CoA dehydrogenase activity','F','Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor.','2013-10-27','NSRP'),(3007,3996,'acyl-CoA ligase activity','F','Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C13 to C22.','2013-10-27','NSRP'),(3008,3997,'acyl-CoA oxidase activity','F','Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide.','2013-10-27','NSRP'),(3009,3998,'acylphosphatase activity','F','Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate.','2013-10-27','NSRP'),(3010,3999,'adenine phosphoribosyltransferase activity','F','Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate.','2013-10-27','NSRP'),(3011,4000,'adenosine deaminase activity','F','Catalysis of the reaction: adenosine + H2O = inosine + NH3.','2013-10-27','NSRP'),(3012,4001,'adenosine kinase activity','F','Catalysis of the reaction: ATP + adenosine = ADP + AMP.','2013-10-27','NSRP'),(3013,4003,'ATP-dependent DNA helicase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.','2013-10-27','NSRP'),(3014,4004,'ATP-dependent RNA helicase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix.','2013-10-27','NSRP'),(3015,4005,'plasma membrane cation-transporting ATPase','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3016,4007,'heavy metal-exporting ATPase activity','F','OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate.','2013-10-27','NSRP'),(3017,4008,'copper-exporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out).','2013-10-27','NSRP'),(3018,4009,'ATP-binding cassette (ABC) transporter activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3019,4012,'phospholipid-translocating ATPase activity','F','Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other (phospolipid \'flippase\' activity), driven by the hydrolysis of ATP.','2013-10-27','NSRP'),(3020,4013,'adenosylhomocysteinase activity','F','Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine.','2013-10-27','NSRP'),(3021,4014,'adenosylmethionine decarboxylase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2).','2013-10-27','NSRP'),(3022,4015,'adenosylmethionine-8-amino-7-oxononanoate transaminase activity','F','Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate.','2013-10-27','NSRP'),(3023,4016,'adenylate cyclase activity','F','Catalysis of the reaction: ATP = 3\',5\'-cyclic AMP + diphosphate.','2013-10-27','NSRP'),(3024,4017,'adenylate kinase activity','F','Catalysis of the reaction: ATP + AMP = 2 ADP.','2013-10-27','NSRP'),(3025,4018,'N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity','F','Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.','2013-10-27','NSRP'),(3026,4019,'adenylosuccinate synthase activity','F','Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.','2013-10-27','NSRP'),(3027,4020,'adenylylsulfate kinase activity','F','Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3\'-phosphoadenosine 5\'-phosphosulfate.','2013-10-27','NSRP'),(3028,4021,'L-alanine:2-oxoglutarate aminotransferase activity','F','Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.','2013-10-27','NSRP'),(3029,4022,'alcohol dehydrogenase (NAD) activity','F','Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.','2013-10-27','NSRP'),(3030,4023,'alcohol dehydrogenase activity, metal ion-independent','F','Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion.','2013-10-27','NSRP'),(3031,4024,'alcohol dehydrogenase activity, zinc-dependent','F','Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc.','2013-10-27','NSRP'),(3032,4025,'alcohol dehydrogenase activity, iron-dependent','F','Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron.','2013-10-27','NSRP'),(3033,4026,'alcohol O-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester.','2013-10-27','NSRP'),(3034,4027,'alcohol sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + an alcohol = adenosine 3\',5\'-bisphosphate + an alkyl sulfate.','2013-10-27','NSRP'),(3035,4028,'3-chloroallyl aldehyde dehydrogenase activity','F','Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid.','2013-10-27','NSRP'),(3036,4029,'aldehyde dehydrogenase (NAD) activity','F','Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+.','2013-10-27','NSRP'),(3037,4030,'aldehyde dehydrogenase [NAD(P)+] activity','F','Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.','2013-10-27','NSRP'),(3038,4031,'aldehyde oxidase activity','F','Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide.','2013-10-27','NSRP'),(3039,4032,'alditol:NADP+ 1-oxidoreductase activity','F','Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.','2013-10-27','NSRP'),(3040,4033,'aldo-keto reductase (NADP) activity','F','Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.','2013-10-27','NSRP'),(3041,4034,'aldose 1-epimerase activity','F','Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose.','2013-10-27','NSRP'),(3042,4035,'alkaline phosphatase activity','F','Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.','2013-10-27','NSRP'),(3043,4037,'allantoicase activity','F','Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea.','2013-10-27','NSRP'),(3044,4038,'allantoinase activity','F','Catalysis of the reaction: allantoin + H2O = allantoate.','2013-10-27','NSRP'),(3045,4039,'allophanate hydrolase activity','F','Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+).','2013-10-27','NSRP'),(3046,4040,'amidase activity','F','Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3.','2013-10-27','NSRP'),(3047,4042,'acetyl-CoA:L-glutamate N-acetyltransferase activity','F','Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+).','2013-10-27','NSRP'),(3048,4043,'L-aminoadipate-semialdehyde dehydrogenase activity','F','Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.','2013-10-27','NSRP'),(3049,4044,'amidophosphoribosyltransferase activity','F','Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O.','2013-10-27','NSRP'),(3050,4045,'aminoacyl-tRNA hydrolase activity','F','Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA.','2013-10-27','NSRP'),(3051,4046,'aminoacylase activity','F','Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid.','2013-10-27','NSRP'),(3052,4047,'aminomethyltransferase activity','F','Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein.','2013-10-27','NSRP'),(3053,4048,'anthranilate phosphoribosyltransferase activity','F','Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate.','2013-10-27','NSRP'),(3054,4049,'anthranilate synthase activity','F','Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.','2013-10-27','NSRP'),(3055,4050,'apyrase activity','F','OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate.','2013-10-27','NSRP'),(3056,4051,'arachidonate 5-lipoxygenase activity','F','Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate.','2013-10-27','NSRP'),(3057,4052,'arachidonate 12-lipoxygenase activity','F','Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate.','2013-10-27','NSRP'),(3058,4053,'arginase activity','F','Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea.','2013-10-27','NSRP'),(3059,4054,'arginine kinase activity','F','Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+).','2013-10-27','NSRP'),(3060,4055,'argininosuccinate synthase activity','F','Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate.','2013-10-27','NSRP'),(3061,4056,'argininosuccinate lyase activity','F','Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.','2013-10-27','NSRP'),(3062,4057,'arginyltransferase activity','F','Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.','2013-10-27','NSRP'),(3063,4058,'aromatic-L-amino-acid decarboxylase activity','F','Catalysis of the reaction: L-tryptophan = tryptamine + CO2.','2013-10-27','NSRP'),(3064,4059,'aralkylamine N-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine.','2013-10-27','NSRP'),(3065,4060,'arylamine N-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.','2013-10-27','NSRP'),(3066,4061,'arylformamidase activity','F','Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine.','2013-10-27','NSRP'),(3067,4062,'aryl sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + a phenol = adenosine 3\',5\'-bisphosphate + an aryl sulfate.','2013-10-27','NSRP'),(3068,4063,'aryldialkylphosphatase activity','F','Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol.','2013-10-27','NSRP'),(3069,4064,'arylesterase activity','F','Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate.','2013-10-27','NSRP'),(3070,4065,'arylsulfatase activity','F','Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate.','2013-10-27','NSRP'),(3071,4066,'asparagine synthase (glutamine-hydrolyzing) activity','F','Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.','2013-10-27','NSRP'),(3072,4067,'asparaginase activity','F','Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3.','2013-10-27','NSRP'),(3073,4068,'aspartate 1-decarboxylase activity','F','Catalysis of the reaction: L-aspartate = beta-alanine + CO2.','2013-10-27','NSRP'),(3074,4069,'L-aspartate:2-oxoglutarate aminotransferase activity','F','Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.','2013-10-27','NSRP'),(3075,4070,'aspartate carbamoyltransferase activity','F','Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.','2013-10-27','NSRP'),(3076,4071,'aspartate-ammonia ligase activity','F','Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine.','2013-10-27','NSRP'),(3077,4072,'aspartate kinase activity','F','Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+).','2013-10-27','NSRP'),(3078,4073,'aspartate-semialdehyde dehydrogenase activity','F','Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH.','2013-10-27','NSRP'),(3079,4074,'biliverdin reductase activity','F','Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+.','2013-10-27','NSRP'),(3080,4075,'biotin carboxylase activity','F','Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein.','2013-10-27','NSRP'),(3081,4076,'biotin synthase activity','F','Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5\'-deoxyadenosine + 2 L-methionine + biotin + H(+).','2013-10-27','NSRP'),(3082,4077,'biotin-[acetyl-CoA-carboxylase] ligase activity','F','Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming)).','2013-10-27','NSRP'),(3083,4078,'biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity','F','Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)).','2013-10-27','NSRP'),(3084,4079,'biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity','F','Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase).','2013-10-27','NSRP'),(3085,4080,'biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity','F','Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming)).','2013-10-27','NSRP'),(3086,4081,'bis(5\'-nucleosyl)-tetraphosphatase (asymmetrical) activity','F','Catalysis of the reaction: P(1),P(4)-bis(5\'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5\'-guanosyl)-, bis(5\'-xanthosyl)-, bis(5\'-adenosyl)- and bis(5\'-uridyl)-tetraphosphate.','2013-10-27','NSRP'),(3087,4082,'bisphosphoglycerate mutase activity','F','Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate.','2013-10-27','NSRP'),(3088,4083,'bisphosphoglycerate 2-phosphatase activity','F','Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate.','2013-10-27','NSRP'),(3089,4084,'branched-chain-amino-acid transaminase activity','F','Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid.','2013-10-27','NSRP'),(3090,4085,'butyryl-CoA dehydrogenase activity','F','Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein.','2013-10-27','NSRP'),(3091,4086,'carbamoyl-phosphate synthase activity','F','OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate.','2013-10-27','NSRP'),(3092,4087,'carbamoyl-phosphate synthase (ammonia) activity','F','Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate.','2013-10-27','NSRP'),(3093,4088,'carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity','F','Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.','2013-10-27','NSRP'),(3094,4089,'carbonate dehydratase activity','F','Catalysis of the reaction: H2CO3 = CO2 + H2O.','2013-10-27','NSRP'),(3095,4090,'carbonyl reductase (NADPH) activity','F','Catalysis of the reaction: R-CHOH-R\' + NADP+ = R-CO-R\' + NADPH + H+.','2013-10-27','NSRP'),(3096,4091,'carboxylesterase activity','F','Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion.','2013-10-27','NSRP'),(3097,4092,'carnitine O-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA.','2013-10-27','NSRP'),(3098,4095,'carnitine O-palmitoyltransferase activity','F','Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.','2013-10-27','NSRP'),(3099,4096,'catalase activity','F','Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O.','2013-10-27','NSRP'),(3100,4097,'catechol oxidase activity','F','Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O.','2013-10-27','NSRP'),(3101,4098,'cerebroside-sulfatase activity','F','Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate.','2013-10-27','NSRP'),(3102,4099,'chitin deacetylase activity','F','Catalysis of the reaction: chitin + H2O = chitosan + acetate.','2013-10-27','NSRP'),(3103,4100,'chitin synthase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1).','2013-10-27','NSRP'),(3104,4102,'choline O-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA.','2013-10-27','NSRP'),(3105,4103,'choline kinase activity','F','Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+).','2013-10-27','NSRP'),(3106,4104,'cholinesterase activity','F','Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion.','2013-10-27','NSRP'),(3107,4105,'choline-phosphate cytidylyltransferase activity','F','Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline.','2013-10-27','NSRP'),(3108,4106,'chorismate mutase activity','F','Catalysis of the reaction: chorismate = prephenate.','2013-10-27','NSRP'),(3109,4107,'chorismate synthase activity','F','Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate.','2013-10-27','NSRP'),(3110,4108,'citrate (Si)-synthase activity','F','Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group.','2013-10-27','NSRP'),(3111,4109,'coproporphyrinogen oxidase activity','F','Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX.','2013-10-27','NSRP'),(3112,4110,'corticosteroid side-chain-isomerase activity','F','Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al.','2013-10-27','NSRP'),(3113,4111,'creatine kinase activity','F','Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+).','2013-10-27','NSRP'),(3114,4112,'cyclic-nucleotide phosphodiesterase activity','F','Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate.','2013-10-27','NSRP'),(3115,4113,'2\',3\'-cyclic-nucleotide 3\'-phosphodiesterase activity','F','Catalysis of the reaction: nucleoside 2\',3\'-cyclic phosphate + H2O = nucleoside 2\'-phosphate.','2013-10-27','NSRP'),(3116,4114,'3\',5\'-cyclic-nucleotide phosphodiesterase activity','F','Catalysis of the reaction: nucleoside 3\',5\'-cyclic phosphate + H2O = nucleoside 5\'-phosphate.','2013-10-27','NSRP'),(3117,4115,'3\',5\'-cyclic-AMP phosphodiesterase activity','F','Catalysis of the reaction: adenosine 3\',5\'-cyclic phosphate + H2O = adenosine 5\'-phosphate.','2013-10-27','NSRP'),(3118,4117,'calmodulin-dependent cyclic-nucleotide phosphodiesterase activity','F','Catalysis of the reaction: nucleoside 3\',5\'-cyclic phosphate + H2O = nucleoside 5\'-phosphate; catalytic activity is regulated by calmodulin.','2013-10-27','NSRP'),(3119,4118,'cGMP-stimulated cyclic-nucleotide phosphodiesterase activity','F','Catalysis of the reaction: nucleoside 3\',5\'-cyclic phosphate + H2O = nucleoside 5\'-phosphate; catalytic activity is increased in the presence of cGMP.','2013-10-27','NSRP'),(3120,4119,'cGMP-inhibited cyclic-nucleotide phosphodiesterase activity','F','Catalysis of the reaction: nucleoside 3\',5\'-cyclic phosphate + H2O = nucleoside 5\'-phosphate; catalytic activity is decreased in the presence of cGMP.','2013-10-27','NSRP'),(3121,4120,'photoreceptor cyclic-nucleotide phosphodiesterase activity','F','Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide.','2013-10-27','NSRP'),(3122,4121,'cystathionine beta-lyase activity','F','Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate.','2013-10-27','NSRP'),(3123,4122,'cystathionine beta-synthase activity','F','Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O.','2013-10-27','NSRP'),(3124,4123,'cystathionine gamma-lyase activity','F','Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+.','2013-10-27','NSRP'),(3125,4124,'cysteine synthase activity','F','Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate.','2013-10-27','NSRP'),(3126,4125,'L-seryl-tRNASec selenium transferase activity','F','Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate.','2013-10-27','NSRP'),(3127,4126,'cytidine deaminase activity','F','Catalysis of the reaction: cytidine + H2O = uridine + NH3.','2013-10-27','NSRP'),(3128,4127,'cytidylate kinase activity','F','Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.','2013-10-27','NSRP'),(3129,4128,'cytochrome-b5 reductase activity, acting on NAD(P)H','F','Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5).','2013-10-27','NSRP'),(3130,4129,'cytochrome-c oxidase activity','F','Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.','2013-10-27','NSRP'),(3131,4130,'cytochrome-c peroxidase activity','F','Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O.','2013-10-27','NSRP'),(3132,4131,'cytosine deaminase activity','F','Catalysis of the reaction: cytosine + H2O = uracil + NH3.','2013-10-27','NSRP'),(3133,4132,'dCMP deaminase activity','F','Catalysis of the reaction: dCMP + H2O = dUMP + NH3.','2013-10-27','NSRP'),(3134,4133,'glycogen debranching enzyme activity','F','Catalysis of the cleavage of branch points in branched glycogen polymers.','2013-10-27','NSRP'),(3135,4134,'4-alpha-glucanotransferase activity','F','Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan.','2013-10-27','NSRP'),(3136,4135,'amylo-alpha-1,6-glucosidase activity','F','Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present.','2013-10-27','NSRP'),(3137,4136,'deoxyadenosine kinase activity','F','Catalysis of the reaction: 2\'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+).','2013-10-27','NSRP'),(3138,4137,'deoxycytidine kinase activity','F','Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP.','2013-10-27','NSRP'),(3139,4138,'deoxyguanosine kinase activity','F','Catalysis of the reaction: 2\'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).','2013-10-27','NSRP'),(3140,4139,'deoxyribose-phosphate aldolase activity','F','Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.','2013-10-27','NSRP'),(3141,4140,'dephospho-CoA kinase activity','F','Catalysis of the reaction: 3\'-dephospho-CoA + ATP = ADP + CoA + 2 H(+).','2013-10-27','NSRP'),(3142,4141,'dethiobiotin synthase activity','F','Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate.','2013-10-27','NSRP'),(3143,4142,'diacylglycerol cholinephosphotransferase activity','F','Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine.','2013-10-27','NSRP'),(3144,4143,'diacylglycerol kinase activity','F','Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.','2013-10-27','NSRP'),(3145,4144,'diacylglycerol O-acyltransferase activity','F','Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.','2013-10-27','NSRP'),(3146,4145,'diamine N-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.','2013-10-27','NSRP'),(3147,4146,'dihydrofolate reductase activity','F','Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.','2013-10-27','NSRP'),(3148,4147,'dihydrolipoamide branched chain acyltransferase activity','F','Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain.','2013-10-27','NSRP'),(3149,4148,'dihydrolipoyl dehydrogenase activity','F','Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+.','2013-10-27','NSRP'),(3150,4149,'dihydrolipoyllysine-residue succinyltransferase activity','F','Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide.','2013-10-27','NSRP'),(3151,4150,'dihydroneopterin aldolase activity','F','Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde.','2013-10-27','NSRP'),(3152,4151,'dihydroorotase activity','F','Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+).','2013-10-27','NSRP'),(3153,4152,'dihydroorotate dehydrogenase activity','F','Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate.','2013-10-27','NSRP'),(3154,4153,'dihydropterin deaminase activity','F','Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3.','2013-10-27','NSRP'),(3155,4154,'dihydropterin oxidase activity','F','Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide.','2013-10-27','NSRP'),(3156,4155,'6,7-dihydropteridine reductase activity','F','Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine.','2013-10-27','NSRP'),(3157,4156,'dihydropteroate synthase activity','F','Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.','2013-10-27','NSRP'),(3158,4157,'dihydropyrimidinase activity','F','Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate.','2013-10-27','NSRP'),(3159,4158,'dihydroorotate oxidase activity','F','Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate.','2013-10-27','NSRP'),(3160,4159,'dihydrouracil dehydrogenase (NAD+) activity','F','Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+.','2013-10-27','NSRP'),(3161,4160,'dihydroxy-acid dehydratase activity','F','Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O.','2013-10-27','NSRP'),(3162,4161,'dimethylallyltranstransferase activity','F','Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.','2013-10-27','NSRP'),(3163,4162,'dimethylnitrosamine demethylase activity','F','Catalysis of the removal of a methyl group from N-nitrosodimethylamine.','2013-10-27','NSRP'),(3164,4163,'diphosphomevalonate decarboxylase activity','F','Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate.','2013-10-27','NSRP'),(3165,4164,'diphthine synthase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine.','2013-10-27','NSRP'),(3166,4165,'dodecenoyl-CoA delta-isomerase activity','F','Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA.','2013-10-27','NSRP'),(3167,4166,'dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate.','2013-10-27','NSRP'),(3168,4167,'dopachrome isomerase activity','F','Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.','2013-10-27','NSRP'),(3169,4168,'dolichol kinase activity','F','Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate.','2013-10-27','NSRP'),(3170,4169,'dolichyl-phosphate-mannose-protein mannosyltransferase activity','F','Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.','2013-10-27','NSRP'),(3171,4170,'dUTP diphosphatase activity','F','Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate.','2013-10-27','NSRP'),(3172,4171,'deoxyhypusine synthase activity','F','OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine.','2013-10-27','NSRP'),(3173,4172,'ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3174,4173,'ecdysone O-acyltransferase activity','F','Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate.','2013-10-27','NSRP'),(3175,4174,'electron-transferring-flavoprotein dehydrogenase activity','F','Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol.','2013-10-27','NSRP'),(3176,4175,'endopeptidase activity','F','Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.','2013-10-27','NSRP'),(3177,4176,'ATP-dependent peptidase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds.','2013-10-27','NSRP'),(3178,4177,'aminopeptidase activity','F','Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain.','2013-10-27','NSRP'),(3179,4178,'leucyl aminopeptidase activity','F','OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro.','2013-10-27','NSRP'),(3180,4179,'membrane alanyl aminopeptidase activity','F','OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.','2013-10-27','NSRP'),(3181,4180,'carboxypeptidase activity','F','Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide.','2013-10-27','NSRP'),(3182,4181,'metallocarboxypeptidase activity','F','Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.','2013-10-27','NSRP'),(3183,4182,'carboxypeptidase A activity','F','OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.','2013-10-27','NSRP'),(3184,4183,'carboxypeptidase E activity','F','OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents.','2013-10-27','NSRP'),(3185,4184,'lysine carboxypeptidase activity','F','OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma.','2013-10-27','NSRP'),(3186,4185,'serine-type carboxypeptidase activity','F','Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).','2013-10-27','NSRP'),(3187,4186,'carboxypeptidase C activity','F','OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.','2013-10-27','NSRP'),(3188,4187,'carboxypeptidase D activity','F','OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents.','2013-10-27','NSRP'),(3189,4188,'serine-type Pro-X carboxypeptidase activity','F','OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid.','2013-10-27','NSRP'),(3190,4189,'tubulinyl-Tyr carboxypeptidase activity','F','OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr.','2013-10-27','NSRP'),(3191,4190,'aspartic-type endopeptidase activity','F','Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.','2013-10-27','NSRP'),(3192,4191,'barrierpepsin activity','F','OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor.','2013-10-27','NSRP'),(3193,4192,'cathepsin D activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin.','2013-10-27','NSRP'),(3194,4193,'cathepsin E activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity.','2013-10-27','NSRP'),(3195,4194,'pepsin A activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1\' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin.','2013-10-27','NSRP'),(3196,4195,'renin activity','F','OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I.','2013-10-27','NSRP'),(3197,4196,'saccharopepsin activity','F','OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24.','2013-10-27','NSRP'),(3198,4197,'cysteine-type endopeptidase activity','F','Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.','2013-10-27','NSRP'),(3199,4198,'calcium-dependent cysteine-type endopeptidase activity','F','Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium.','2013-10-27','NSRP'),(3200,4200,'signaling (initiator) caspase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3201,4201,'caspase-1 activity','F','OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec.','2013-10-27','NSRP'),(3202,4202,'caspase-2 activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3203,4203,'caspase-4 activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3204,4204,'caspase-5 activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3205,4205,'caspase-8 activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3206,4206,'caspase-10 activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3207,4207,'effector caspase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3208,4208,'caspase-3 activity','F','OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis.','2013-10-27','NSRP'),(3209,4209,'caspase-6 activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3210,4210,'caspase-7 activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3211,4211,'caspase-9 activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3212,4212,'lysosomal cysteine-type endopeptidase','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3213,4213,'cathepsin B activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.','2013-10-27','NSRP'),(3214,4214,'dipeptidyl-peptidase I activity','F','OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro.','2013-10-27','NSRP'),(3215,4215,'cathepsin H activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase.','2013-10-27','NSRP'),(3216,4216,'cathepsin K activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg.','2013-10-27','NSRP'),(3217,4217,'cathepsin L activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.','2013-10-27','NSRP'),(3218,4218,'cathepsin S activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds.','2013-10-27','NSRP'),(3219,4219,'pyroglutamyl-peptidase I activity','F','OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide.','2013-10-27','NSRP'),(3220,4221,'ubiquitin thiolesterase activity','F','Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.','2013-10-27','NSRP'),(3221,4222,'metalloendopeptidase activity','F','Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.','2013-10-27','NSRP'),(3222,4226,'Gly-X carboxypeptidase activity','F','OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa.','2013-10-27','NSRP'),(3223,4228,'gelatinase A activity','F','OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond.','2013-10-27','NSRP'),(3224,4229,'gelatinase B activity','F','OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V.','2013-10-27','NSRP'),(3225,4230,'glutamyl aminopeptidase activity','F','OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide.','2013-10-27','NSRP'),(3226,4231,'insulysin activity','F','OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins.','2013-10-27','NSRP'),(3227,4232,'interstitial collagenase activity','F','OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1\' is a hydrophobic residue.','2013-10-27','NSRP'),(3228,4234,'macrophage elastase activity','F','OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin.','2013-10-27','NSRP'),(3229,4235,'matrilysin activity','F','OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).','2013-10-27','NSRP'),(3230,4237,'membrane dipeptidase activity','F','OBSOLETE. Catalysis of the hydrolysis of dipeptides.','2013-10-27','NSRP'),(3231,4238,'meprin A activity','F','OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues.','2013-10-27','NSRP'),(3232,4239,'methionyl aminopeptidase activity','F','OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.','2013-10-27','NSRP'),(3233,4240,'mitochondrial processing peptidase activity','F','OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.','2013-10-27','NSRP'),(3234,4241,'alpha-mitochondrial processing peptidase','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3235,4242,'beta-mitochondrial processing peptidase','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(3236,4243,'mitochondrial intermediate peptidase activity','F','OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion.','2013-10-27','NSRP'),(3237,4244,'mitochondrial inner membrane peptidase activity','F','OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space.','2013-10-27','NSRP'),(3238,4245,'neprilysin activity','F','OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides.','2013-10-27','NSRP'),(3239,4246,'peptidyl-dipeptidase A activity','F','OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.','2013-10-27','NSRP'),(3240,4247,'saccharolysin activity','F','OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds.','2013-10-27','NSRP'),(3241,4248,'stromelysin 1 activity','F','OBSOLETE. Catalysis of the preferential cleavage where P1\', P2\' and P3\' are hydrophobic residues.','2013-10-27','NSRP'),(3242,4249,'stromelysin 3 activity','F','OBSOLETE. Was not defined before being made obsolete.','2013-10-27','NSRP'),(3243,4250,'aminopeptidase I activity','F','OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.','2013-10-27','NSRP'),(3244,4251,'X-Pro dipeptidase activity','F','OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.','2013-10-27','NSRP'),(3245,4252,'serine-type endopeptidase activity','F','Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).','2013-10-27','NSRP'),(3246,4253,'gamma-renin activity','F','OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide.','2013-10-27','NSRP'),(3247,4254,'acylaminoacyl-peptidase activity','F','OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide.','2013-10-27','NSRP'),(3248,4258,'vacuolar carboxypeptidase Y','F','OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity.','2013-10-27','NSRP'),(3249,4261,'cathepsin G activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C.','2013-10-27','NSRP'),(3250,4262,'cerevisin activity','F','OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides.','2013-10-27','NSRP'),(3251,4263,'chymotrypsin activity','F','OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa.','2013-10-27','NSRP'),(3252,4274,'dipeptidyl-peptidase IV activity','F','OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline.','2013-10-27','NSRP'),(3253,4275,'enteropeptidase activity','F','OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen.','2013-10-27','NSRP'),(3254,4276,'furin activity','F','OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.','2013-10-27','NSRP'),(3255,4277,'granzyme A activity','F','OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates.','2013-10-27','NSRP'),(3256,4278,'granzyme B activity','F','OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa.','2013-10-27','NSRP'),(3257,4281,'pancreatic elastase II activity','F','OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin.','2013-10-27','NSRP'),(3258,4283,'plasmin activity','F','OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.','2013-10-27','NSRP'),(3259,4284,'acrosin activity','F','OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa.','2013-10-27','NSRP'),(3260,4285,'proprotein convertase 1 activity','F','OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.','2013-10-27','NSRP'),(3261,4286,'proprotein convertase 2 activity','F','OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond.','2013-10-27','NSRP'),(3262,4287,'prolyl oligopeptidase activity','F','OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides.','2013-10-27','NSRP'),(3263,4289,'subtilase activity','F','OBSOLETE. Was not defined before being made obsolete.','2013-10-27','NSRP'),(3264,4290,'kexin activity','F','OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors.','2013-10-27','NSRP'),(3265,4291,'subtilisin activity','F','OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.','2013-10-27','NSRP'),(3266,4293,'tissue kallikrein activity','F','OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds.','2013-10-27','NSRP'),(3267,4294,'tripeptidyl-peptidase II activity','F','OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH.','2013-10-27','NSRP'),(3268,4295,'trypsin activity','F','OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa.','2013-10-27','NSRP'),(3269,4298,'threonine-type endopeptidase activity','F','Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile.','2013-10-27','NSRP'),(3270,4299,'proteasome endopeptidase activity','F','OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity.','2013-10-27','NSRP'),(3271,4300,'enoyl-CoA hydratase activity','F','Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O.','2013-10-27','NSRP'),(3272,4301,'epoxide hydrolase activity','F','Catalysis of the reaction: an epoxide + H2O = a glycol.','2013-10-27','NSRP'),(3273,4303,'estradiol 17-beta-dehydrogenase activity','F','Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+.','2013-10-27','NSRP'),(3274,4304,'estrone sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + estrone = adenosine 3\',5\'-bisphosphate + estrone 3-sulfate.','2013-10-27','NSRP'),(3275,4305,'ethanolamine kinase activity','F','Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine.','2013-10-27','NSRP'),(3276,4306,'ethanolamine-phosphate cytidylyltransferase activity','F','Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.','2013-10-27','NSRP'),(3277,4307,'ethanolaminephosphotransferase activity','F','Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine.','2013-10-27','NSRP'),(3278,4308,'exo-alpha-sialidase activity','F','Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.','2013-10-27','NSRP'),(3279,4309,'exopolyphosphatase activity','F','Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate.','2013-10-27','NSRP'),(3280,4310,'farnesyl-diphosphate farnesyltransferase activity','F','Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate.','2013-10-27','NSRP'),(3281,4311,'farnesyltranstransferase activity','F','Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.','2013-10-27','NSRP'),(3282,4312,'fatty acid synthase activity','F','Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+.','2013-10-27','NSRP'),(3283,4313,'[acyl-carrier-protein] S-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein].','2013-10-27','NSRP'),(3284,4314,'[acyl-carrier-protein] S-malonyltransferase activity','F','Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein].','2013-10-27','NSRP'),(3285,4315,'3-oxoacyl-[acyl-carrier-protein] synthase activity','F','Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein].','2013-10-27','NSRP'),(3286,4316,'3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity','F','Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+.','2013-10-27','NSRP'),(3287,4317,'3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity','F','Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O.','2013-10-27','NSRP'),(3288,4318,'enoyl-[acyl-carrier-protein] reductase (NADH) activity','F','Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+.','2013-10-27','NSRP'),(3289,4319,'enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity','F','Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+.','2013-10-27','NSRP'),(3290,4320,'oleoyl-[acyl-carrier-protein] hydrolase activity','F','Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate.','2013-10-27','NSRP'),(3291,4321,'fatty-acyl-CoA synthase activity','F','Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+.','2013-10-27','NSRP'),(3292,4322,'ferroxidase activity','F','Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.','2013-10-27','NSRP'),(3293,4323,'multicopper ferroxidase iron transport mediator activity','F','OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.','2013-10-27','NSRP'),(3294,4324,'ferredoxin-NADP+ reductase activity','F','Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+.','2013-10-27','NSRP'),(3295,4325,'ferrochelatase activity','F','Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX.','2013-10-27','NSRP'),(3296,4326,'tetrahydrofolylpolyglutamate synthase activity','F','Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1).','2013-10-27','NSRP'),(3297,4327,'formaldehyde dehydrogenase (glutathione) activity','F','OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+.','2013-10-27','NSRP'),(3298,4328,'formamidase activity','F','Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+).','2013-10-27','NSRP'),(3299,4329,'formate-tetrahydrofolate ligase activity','F','Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.','2013-10-27','NSRP'),(3300,4331,'fructose-2,6-bisphosphate 2-phosphatase activity','F','Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate.','2013-10-27','NSRP'),(3301,4332,'fructose-bisphosphate aldolase activity','F','Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate.','2013-10-27','NSRP'),(3302,4333,'fumarate hydratase activity','F','Catalysis of the reaction: (S)-malate = fumarate + H(2)O.','2013-10-27','NSRP'),(3303,4334,'fumarylacetoacetase activity','F','Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+).','2013-10-27','NSRP'),(3304,4335,'galactokinase activity','F','Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(3305,4336,'galactosylceramidase activity','F','Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine.','2013-10-27','NSRP'),(3306,4337,'geranyltranstransferase activity','F','Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate.','2013-10-27','NSRP'),(3307,4338,'glucan exo-1,3-beta-glucosidase activity','F','Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.','2013-10-27','NSRP'),(3308,4339,'glucan 1,4-alpha-glucosidase activity','F','Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.','2013-10-27','NSRP'),(3309,4340,'glucokinase activity','F','Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate.','2013-10-27','NSRP'),(3310,4341,'gluconolactonase activity','F','Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate.','2013-10-27','NSRP'),(3311,4342,'glucosamine-6-phosphate deaminase activity','F','Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+).','2013-10-27','NSRP'),(3312,4343,'glucosamine 6-phosphate N-acetyltransferase activity','F','Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+).','2013-10-27','NSRP'),(3313,4344,'glucose dehydrogenase activity','F','Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor.','2013-10-27','NSRP'),(3314,4345,'glucose-6-phosphate dehydrogenase activity','F','Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+.','2013-10-27','NSRP'),(3315,4346,'glucose-6-phosphatase activity','F','Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate.','2013-10-27','NSRP'),(3316,4347,'glucose-6-phosphate isomerase activity','F','Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate.','2013-10-27','NSRP'),(3317,4348,'glucosylceramidase activity','F','Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine.','2013-10-27','NSRP'),(3318,4349,'glutamate 5-kinase activity','F','Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+).','2013-10-27','NSRP'),(3319,4350,'glutamate-5-semialdehyde dehydrogenase activity','F','Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH.','2013-10-27','NSRP'),(3320,4351,'glutamate decarboxylase activity','F','Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.','2013-10-27','NSRP'),(3321,4352,'glutamate dehydrogenase (NAD+) activity','F','Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+.','2013-10-27','NSRP'),(3322,4353,'glutamate dehydrogenase [NAD(P)+] activity','F','Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+.','2013-10-27','NSRP'),(3323,4354,'glutamate dehydrogenase (NADP+) activity','F','Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.','2013-10-27','NSRP'),(3324,4355,'glutamate synthase (NADPH) activity','F','Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+.','2013-10-27','NSRP'),(3325,4356,'glutamate-ammonia ligase activity','F','Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate.','2013-10-27','NSRP'),(3326,4357,'glutamate-cysteine ligase activity','F','Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate.','2013-10-27','NSRP'),(3327,4358,'glutamate N-acetyltransferase activity','F','Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine.','2013-10-27','NSRP'),(3328,4359,'glutaminase activity','F','Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.','2013-10-27','NSRP'),(3329,4360,'glutamine-fructose-6-phosphate transaminase (isomerizing) activity','F','Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate.','2013-10-27','NSRP'),(3330,4361,'glutaryl-CoA dehydrogenase activity','F','Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor.','2013-10-27','NSRP'),(3331,4362,'glutathione-disulfide reductase activity','F','Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.','2013-10-27','NSRP'),(3332,4363,'glutathione synthase activity','F','Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate.','2013-10-27','NSRP'),(3333,4364,'glutathione transferase activity','F','Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.','2013-10-27','NSRP'),(3334,4365,'glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity','F','Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+.','2013-10-27','NSRP'),(3335,4366,'glycerol-3-phosphate O-acyltransferase activity','F','Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.','2013-10-27','NSRP'),(3336,4367,'glycerol-3-phosphate dehydrogenase [NAD+] activity','F','Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+.','2013-10-27','NSRP'),(3337,4368,'glycerol-3-phosphate dehydrogenase activity','F','Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.','2013-10-27','NSRP'),(3338,4369,'glycerol-3-phosphate oxidase activity','F','Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2).','2013-10-27','NSRP'),(3339,4370,'glycerol kinase activity','F','Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(3340,4371,'glycerone kinase activity','F','Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+).','2013-10-27','NSRP'),(3341,4372,'glycine hydroxymethyltransferase activity','F','Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.','2013-10-27','NSRP'),(3342,4373,'glycogen (starch) synthase activity','F','Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1).','2013-10-27','NSRP'),(3343,4374,'glycine cleavage system','F','OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating).','2013-10-27','NSRP'),(3344,4375,'glycine dehydrogenase (decarboxylating) activity','F','Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.','2013-10-27','NSRP'),(3345,4376,'glycolipid mannosyltransferase activity','F','Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage.','2013-10-27','NSRP'),(3346,4377,'GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity','F','Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage.','2013-10-27','NSRP'),(3347,4378,'GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity','F','Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage.','2013-10-27','NSRP'),(3348,4379,'glycylpeptide N-tetradecanoyltransferase activity','F','Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide.','2013-10-27','NSRP'),(3349,4380,'glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.','2013-10-27','NSRP'),(3350,4381,'fucosylgalactoside 3-alpha-galactosyltransferase activity','F','Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose.','2013-10-27','NSRP'),(3351,4382,'guanosine-diphosphatase activity','F','Catalysis of the reaction: GDP + H2O = GMP + phosphate.','2013-10-27','NSRP'),(3352,4383,'guanylate cyclase activity','F','Catalysis of the reaction: GTP = 3\',5\'-cyclic GMP + diphosphate.','2013-10-27','NSRP'),(3353,4384,'membrane-associated guanylate kinase','F','OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane.','2013-10-27','NSRP'),(3354,4385,'guanylate kinase activity','F','Catalysis of the reaction: ATP + GMP = ADP + GDP.','2013-10-27','NSRP'),(3355,4386,'helicase activity','F','Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix.','2013-10-27','NSRP'),(3356,4392,'heme oxygenase (decyclizing) activity','F','Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O.','2013-10-27','NSRP'),(3357,4394,'heparan sulfate 2-O-sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + heparan sulfate = adenosine 3\',5\'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate.','2013-10-27','NSRP'),(3358,4395,'hexaprenyldihydroxybenzoate methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate.','2013-10-27','NSRP'),(3359,4396,'hexokinase activity','F','Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.','2013-10-27','NSRP'),(3360,4397,'histidine ammonia-lyase activity','F','Catalysis of the reaction: L-histidine = urocanate + NH3.','2013-10-27','NSRP'),(3361,4398,'histidine decarboxylase activity','F','Catalysis of the reaction: L-histidine = histamine + CO2.','2013-10-27','NSRP'),(3362,4399,'histidinol dehydrogenase activity','F','Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+.','2013-10-27','NSRP'),(3363,4400,'histidinol-phosphate transaminase activity','F','Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.','2013-10-27','NSRP'),(3364,4401,'histidinol-phosphatase activity','F','Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate.','2013-10-27','NSRP'),(3365,4402,'histone acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone.','2013-10-27','NSRP'),(3366,4407,'histone deacetylase activity','F','Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.','2013-10-27','NSRP'),(3367,4408,'holocytochrome-c synthase activity','F','Catalysis of the reaction: holocytochrome c = apocytochrome c + heme.','2013-10-27','NSRP'),(3368,4409,'homoaconitate hydratase activity','F','Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O.','2013-10-27','NSRP'),(3369,4410,'homocitrate synthase activity','F','Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate.','2013-10-27','NSRP'),(3370,4411,'homogentisate 1,2-dioxygenase activity','F','Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).','2013-10-27','NSRP'),(3371,4412,'homoserine dehydrogenase activity','F','Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+.','2013-10-27','NSRP'),(3372,4413,'homoserine kinase activity','F','Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+).','2013-10-27','NSRP'),(3373,4414,'homoserine O-acetyltransferase activity','F','Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA.','2013-10-27','NSRP'),(3374,4415,'hyalurononglucosaminidase activity','F','Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.','2013-10-27','NSRP'),(3375,4416,'hydroxyacylglutathione hydrolase activity','F','Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.','2013-10-27','NSRP'),(3376,4417,'hydroxyethylthiazole kinase activity','F','Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+).','2013-10-27','NSRP'),(3377,4418,'hydroxymethylbilane synthase activity','F','Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+).','2013-10-27','NSRP'),(3378,4419,'hydroxymethylglutaryl-CoA lyase activity','F','Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA.','2013-10-27','NSRP'),(3379,4420,'hydroxymethylglutaryl-CoA reductase (NADPH) activity','F','Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH.','2013-10-27','NSRP'),(3380,4421,'hydroxymethylglutaryl-CoA synthase activity','F','Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+).','2013-10-27','NSRP'),(3381,4422,'hypoxanthine phosphoribosyltransferase activity','F','Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.','2013-10-27','NSRP'),(3382,4423,'iduronate-2-sulfatase activity','F','Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.','2013-10-27','NSRP'),(3383,4424,'imidazoleglycerol-phosphate dehydratase activity','F','Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O.','2013-10-27','NSRP'),(3384,4425,'indole-3-glycerol-phosphate synthase activity','F','Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O.','2013-10-27','NSRP'),(3385,4427,'inorganic diphosphatase activity','F','Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate.','2013-10-27','NSRP'),(3386,4428,'inositol or phosphatidylinositol kinase activity','F','OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.','2013-10-27','NSRP'),(3387,4430,'1-phosphatidylinositol 4-kinase activity','F','Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(3388,4432,'1-phosphatidylinositol-4-phosphate kinase, class IA','F','OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events.','2013-10-27','NSRP'),(3389,4433,'1-phosphatidylinositol-4-phosphate kinase, class IB','F','OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins.','2013-10-27','NSRP'),(3390,4435,'phosphatidylinositol phospholipase C activity','F','Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+).','2013-10-27','NSRP'),(3391,4436,'phosphatidylinositol diacylglycerol-lyase activity','F','Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol.','2013-10-27','NSRP'),(3392,4437,'inositol or phosphatidylinositol phosphatase activity','F','OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol.','2013-10-27','NSRP'),(3393,4438,'phosphatidylinositol-3-phosphatase activity','F','Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.','2013-10-27','NSRP'),(3394,4439,'phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity','F','Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.','2013-10-27','NSRP'),(3395,4441,'inositol-1,4-bisphosphate 1-phosphatase activity','F','Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.','2013-10-27','NSRP'),(3396,4442,'inositol-1,4,-bisphosphate 3-phosphatase','F','OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate.','2013-10-27','NSRP'),(3397,4443,'inositol-1,4,-bisphosphate 4-phosphatase','F','OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate.','2013-10-27','NSRP'),(3398,4444,'inositol-1,4,5-trisphosphate 1-phosphatase','F','OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate.','2013-10-27','NSRP'),(3399,4445,'inositol-polyphosphate 5-phosphatase activity','F','Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.','2013-10-27','NSRP'),(3400,4446,'inositol-hexakisphosphate phosphatase activity','F','Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.','2013-10-27','NSRP'),(3401,4447,'iodide peroxidase activity','F','Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O.','2013-10-27','NSRP'),(3402,4448,'isocitrate dehydrogenase activity','F','Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor.','2013-10-27','NSRP'),(3403,4449,'isocitrate dehydrogenase (NAD+) activity','F','Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+.','2013-10-27','NSRP'),(3404,4450,'isocitrate dehydrogenase (NADP+) activity','F','Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+.','2013-10-27','NSRP'),(3405,4451,'isocitrate lyase activity','F','Catalysis of the reaction: isocitrate = glyoxylate + succinate.','2013-10-27','NSRP'),(3406,4452,'isopentenyl-diphosphate delta-isomerase activity','F','Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate.','2013-10-27','NSRP'),(3407,4453,'juvenile-hormone esterase activity','F','Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone.','2013-10-27','NSRP'),(3408,4454,'ketohexokinase activity','F','Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate.','2013-10-27','NSRP'),(3409,4455,'ketol-acid reductoisomerase activity','F','Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+.','2013-10-27','NSRP'),(3410,4456,'phosphogluconate dehydratase activity','F','Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O.','2013-10-27','NSRP'),(3411,4457,'lactate dehydrogenase activity','F','Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate.','2013-10-27','NSRP'),(3412,4458,'D-lactate dehydrogenase (cytochrome) activity','F','Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.','2013-10-27','NSRP'),(3413,4459,'L-lactate dehydrogenase activity','F','Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+.','2013-10-27','NSRP'),(3414,4460,'L-lactate dehydrogenase (cytochrome) activity','F','Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.','2013-10-27','NSRP'),(3415,4461,'lactose synthase activity','F','Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.','2013-10-27','NSRP'),(3416,4462,'lactoylglutathione lyase activity','F','Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.','2013-10-27','NSRP'),(3417,4463,'leukotriene-A4 hydrolase activity','F','Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4).','2013-10-27','NSRP'),(3418,4464,'leukotriene-C4 synthase activity','F','Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4).','2013-10-27','NSRP'),(3419,4465,'lipoprotein lipase activity','F','Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.','2013-10-27','NSRP'),(3420,4466,'long-chain-acyl-CoA dehydrogenase activity','F','Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF.','2013-10-27','NSRP'),(3421,4467,'long-chain fatty acid-CoA ligase activity','F','Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.','2013-10-27','NSRP'),(3422,4468,'lysine N-acetyltransferase activity','F','Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine.','2013-10-27','NSRP'),(3423,4470,'malic enzyme activity','F','Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.','2013-10-27','NSRP'),(3424,4471,'malate dehydrogenase (decarboxylating) activity','F','Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate.','2013-10-27','NSRP'),(3425,4473,'malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity','F','Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate.','2013-10-27','NSRP'),(3426,4474,'malate synthase activity','F','Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+).','2013-10-27','NSRP'),(3427,4475,'mannose-1-phosphate guanylyltransferase activity','F','Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose.','2013-10-27','NSRP'),(3428,4476,'mannose-6-phosphate isomerase activity','F','Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.','2013-10-27','NSRP'),(3429,4477,'methenyltetrahydrofolate cyclohydrolase activity','F','Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.','2013-10-27','NSRP'),(3430,4478,'methionine adenosyltransferase activity','F','Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine.','2013-10-27','NSRP'),(3431,4479,'methionyl-tRNA formyltransferase activity','F','Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA.','2013-10-27','NSRP'),(3432,4481,'methylene-fatty-acyl-phospholipid synthase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid.','2013-10-27','NSRP'),(3433,4482,'mRNA (guanine-N7-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + G(5\')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5\')pppR-RNA. m7G(5\')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine.','2013-10-27','NSRP'),(3434,4483,'mRNA (nucleoside-2\'-O-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5\')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5\')pppRm-RNA. R may be guanosine or adenosine.','2013-10-27','NSRP'),(3435,4484,'mRNA guanylyltransferase activity','F','Catalysis of the reaction: GTP + (5\')pp-Pur-mRNA = diphosphate + G(5\')ppp-Pur-mRNA; G(5\')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5\' through three phosphates to the 5\' position of the terminal residue.','2013-10-27','NSRP'),(3436,4485,'methylcrotonoyl-CoA carboxylase activity','F','Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate.','2013-10-27','NSRP'),(3437,4486,'methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity','F','Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+.','2013-10-27','NSRP'),(3438,4487,'methylenetetrahydrofolate dehydrogenase (NAD+) activity','F','Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH.','2013-10-27','NSRP'),(3439,4488,'methylenetetrahydrofolate dehydrogenase (NADP+) activity','F','Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.','2013-10-27','NSRP'),(3440,4489,'methylenetetrahydrofolate reductase (NAD(P)H) activity','F','Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+.','2013-10-27','NSRP'),(3441,4490,'methylglutaconyl-CoA hydratase activity','F','Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O.','2013-10-27','NSRP'),(3442,4491,'methylmalonate-semialdehyde dehydrogenase (acylating) activity','F','Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+.','2013-10-27','NSRP'),(3443,4492,'methylmalonyl-CoA decarboxylase activity','F','Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2.','2013-10-27','NSRP'),(3444,4493,'methylmalonyl-CoA epimerase activity','F','Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA.','2013-10-27','NSRP'),(3445,4494,'methylmalonyl-CoA mutase activity','F','Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA.','2013-10-27','NSRP'),(3446,4495,'mevaldate reductase activity','F','Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor.','2013-10-27','NSRP'),(3447,4496,'mevalonate kinase activity','F','Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+).','2013-10-27','NSRP'),(3448,4497,'monooxygenase activity','F','Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water.','2013-10-27','NSRP'),(3449,4498,'calcidiol 1-monooxygenase activity','F','Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+).','2013-10-27','NSRP'),(3450,4499,'N,N-dimethylaniline monooxygenase activity','F','Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O.','2013-10-27','NSRP'),(3451,4500,'dopamine beta-monooxygenase activity','F','Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O.','2013-10-27','NSRP'),(3452,4501,'ecdysone 20-monooxygenase activity','F','Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O.','2013-10-27','NSRP'),(3453,4502,'kynurenine 3-monooxygenase activity','F','Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+).','2013-10-27','NSRP'),(3454,4503,'monophenol monooxygenase activity','F','Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O.','2013-10-27','NSRP'),(3455,4504,'peptidylglycine monooxygenase activity','F','Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O.','2013-10-27','NSRP'),