(20487,42785,'active evasion of host immune response via regulation of host cytokine network','P','Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(20488,42786,'active evasion of host immune response via regulation of host antigen processing and presentation','P','Any mechanism of active immune avoidance which works by regulating the host\'s antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(20489,42787,'protein ubiquitination involved in ubiquitin-dependent protein catabolic process','P','The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein.','2013-10-27','NSRP'),(20490,42788,'polysomal ribosome','C','A ribosome bound to mRNA that forms part of a polysome.','2013-10-27','NSRP'),(20491,42789,'mRNA transcription from RNA polymerase II promoter','P','The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter.','2013-10-27','NSRP'),(20492,42790,'transcription of nuclear large rRNA transcript from RNA polymerase I promoter','P','The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I.','2013-10-27','NSRP'),(20493,42791,'5S class rRNA transcription from RNA polymerase III type 1 promoter','P','The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter.','2013-10-27','NSRP'),(20494,42792,'rRNA transcription from mitochondrial promoter','P','The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template.','2013-10-27','NSRP'),(20495,42793,'transcription from plastid promoter','P','The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase.','2013-10-27','NSRP'),(20496,42794,'rRNA transcription from plastid promoter','P','The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase.','2013-10-27','NSRP'),(20497,42795,'snRNA transcription from RNA polymerase II promoter','P','The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.','2013-10-27','NSRP'),(20498,42796,'snRNA transcription from RNA polymerase III promoter','P','The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter.','2013-10-27','NSRP'),(20499,42797,'tRNA transcription from RNA polymerase III promoter','P','The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter.','2013-10-27','NSRP'),(20500,42798,'protein neddylation during NEDD8 class-dependent protein catabolic process','P','OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism.','2013-10-27','NSRP'),(20501,42799,'histone methyltransferase activity (H4-K20 specific)','F','Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein.','2013-10-27','NSRP'),(20502,42800,'histone methyltransferase activity (H3-K4 specific)','F','Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein.','2013-10-27','NSRP'),(20503,42801,'polo kinase kinase activity','F','Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins.','2013-10-27','NSRP'),(20504,42802,'identical protein binding','F','Interacting selectively and non-covalently with an identical protein or proteins.','2013-10-27','NSRP'),(20505,42803,'protein homodimerization activity','F','Interacting selectively and non-covalently with an identical protein to form a homodimer.','2013-10-27','NSRP'),(20506,42804,'protein homooligomerization activity','F','OBSOLETE. Interacting selectively with identical proteins to form a homooligomer.','2013-10-27','NSRP'),(20507,42805,'actinin binding','F','Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin.','2013-10-27','NSRP'),(20508,42806,'fucose binding','F','Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose.','2013-10-27','NSRP'),(20509,42807,'central vacuole','C','A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination.','2013-10-27','NSRP'),(20510,42808,'neuronal Cdc2-like kinase binding','F','OBSOLETE. Interacting selectively and non-covalently with neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics.','2013-10-27','NSRP'),(20511,42809,'vitamin D receptor binding','F','Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.','2013-10-27','NSRP'),(20512,42810,'pheromone metabolic process','P','The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process.','2013-10-27','NSRP'),(20513,42811,'pheromone biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process.','2013-10-27','NSRP'),(20514,42812,'pheromone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process.','2013-10-27','NSRP'),(20515,42813,'Wnt-activated receptor activity','F','Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.','2013-10-27','NSRP'),(20516,42814,'monopolar cell growth','P','Polarized growth from one end of a cell.','2013-10-27','NSRP'),(20517,42815,'bipolar cell growth','P','The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell.','2013-10-27','NSRP'),(20518,42816,'vitamin B6 metabolic process','P','The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.','2013-10-27','NSRP'),(20519,42817,'pyridoxal metabolic process','P','The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.','2013-10-27','NSRP'),(20520,42818,'pyridoxamine metabolic process','P','The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.','2013-10-27','NSRP'),(20521,42819,'vitamin B6 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.','2013-10-27','NSRP'),(20522,42820,'vitamin B6 catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate.','2013-10-27','NSRP'),(20523,42821,'pyridoxal biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds.','2013-10-27','NSRP'),(20524,42822,'pyridoxal phosphate metabolic process','P','The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.','2013-10-27','NSRP'),(20525,42823,'pyridoxal phosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.','2013-10-27','NSRP'),(20526,42824,'MHC class I peptide loading complex','C','A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules.','2013-10-27','NSRP'),(20527,42825,'TAP complex','C','A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum.','2013-10-27','NSRP'),(20528,42826,'histone deacetylase binding','F','Interacting selectively and non-covalently with the enzyme histone deacetylase.','2013-10-27','NSRP'),(20529,42827,'platelet dense granule','C','Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins.','2013-10-27','NSRP'),(20530,42832,'defense response to protozoan','P','Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism.','2013-10-27','NSRP'),(20531,42834,'peptidoglycan binding','F','Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.','2013-10-27','NSRP'),(20532,42835,'BRE binding','F','Interacting selectively and non-covalently with the RNA element BRE (Bruno response element).','2013-10-27','NSRP'),(20533,42836,'D-glucarate metabolic process','P','The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose.','2013-10-27','NSRP'),(20534,42837,'D-glucarate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate.','2013-10-27','NSRP'),(20535,42838,'D-glucarate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate.','2013-10-27','NSRP'),(20536,42839,'D-glucuronate metabolic process','P','The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate.','2013-10-27','NSRP'),(20537,42840,'D-glucuronate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate.','2013-10-27','NSRP'),(20538,42841,'D-glucuronate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate.','2013-10-27','NSRP'),(20539,42842,'D-xylose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide.','2013-10-27','NSRP'),(20540,42843,'D-xylose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide.','2013-10-27','NSRP'),(20541,42844,'glycol metabolic process','P','The chemical reactions and pathways involving glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent.','2013-10-27','NSRP'),(20542,42845,'glycol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent.','2013-10-27','NSRP'),(20543,42846,'glycol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent.','2013-10-27','NSRP'),(20544,42847,'sorbose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid.','2013-10-27','NSRP'),(20545,42848,'sorbose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid.','2013-10-27','NSRP'),(20546,42849,'L-sorbose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol.','2013-10-27','NSRP'),(20547,42850,'L-sorbose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose.','2013-10-27','NSRP'),(20548,42851,'L-alanine metabolic process','P','The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.','2013-10-27','NSRP'),(20549,42852,'L-alanine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.','2013-10-27','NSRP'),(20550,42853,'L-alanine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid.','2013-10-27','NSRP'),(20551,42854,'eugenol metabolic process','P','The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil.','2013-10-27','NSRP'),(20552,42855,'eugenol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil.','2013-10-27','NSRP'),(20553,42856,'eugenol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil.','2013-10-27','NSRP'),(20554,42857,'chrysobactin metabolic process','P','The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine).','2013-10-27','NSRP'),(20555,42858,'chrysobactin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine).','2013-10-27','NSRP'),(20556,42859,'chrysobactin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine).','2013-10-27','NSRP'),(20557,42860,'achromobactin metabolic process','P','The chemical reactions and pathways involving achromobactin, a citrate siderophore.','2013-10-27','NSRP'),(20558,42861,'achromobactin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore.','2013-10-27','NSRP'),(20559,42862,'achromobactin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore.','2013-10-27','NSRP'),(20560,42863,'pyochelin metabolic process','P','The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid).','2013-10-27','NSRP'),(20561,42864,'pyochelin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid).','2013-10-27','NSRP'),(20562,42865,'pyochelin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid).','2013-10-27','NSRP'),(20563,42866,'pyruvate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.','2013-10-27','NSRP'),(20564,42867,'pyruvate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate.','2013-10-27','NSRP'),(20565,42868,'antisense RNA metabolic process','P','The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis.','2013-10-27','NSRP'),(20566,42869,'aldarate transport','P','The directed movement of aldarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20567,42870,'D-glucarate transport','P','The directed movement of D-glucarate, the D-enantiomer of glucarate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20568,42871,'D-galactarate transport','P','The directed movement of D-galactarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. D-galactarate is the D-enantiomer of galactarate, the anion of galactaric acid.','2013-07-14','NSRP'),(20569,42872,'D-galactarate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of D-galactarate, the D-enantiomer of the anion of galactaric acid.','2013-07-14','NSRP'),(20570,42873,'aldonate transport','P','The directed movement of aldonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20571,42874,'D-glucuronate transport','P','The directed movement of D-glucuronate, the D-enantiomer of glucuronate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20572,42875,'D-galactonate transport','P','The directed movement of D-galactonate, the D-enantiomer of galactonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20573,42876,'aldarate transmembrane transporter activity','F','Catalysis of the transfer of aldarate from one side of the membrane to the other.','2013-10-27','NSRP'),(20574,42877,'D-galactarate transmembrane transporter activity','F','Catalysis of the transfer of D-galactarate, the D-enantiomer of the anion of galactaric acid, from one side of the membrane to the other.','2013-07-14','NSRP'),(20575,42878,'D-glucarate transmembrane transporter activity','F','Catalysis of the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of the membrane to the other.','2013-10-27','NSRP'),(20576,42879,'aldonate transmembrane transporter activity','F','Catalysis of the transfer of aldonate from one side of the membrane to the other.','2013-10-27','NSRP'),(20577,42880,'D-glucuronate transmembrane transporter activity','F','Catalysis of the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of the membrane to the other.','2013-10-27','NSRP'),(20578,42881,'D-galactonate transmembrane transporter activity','F','Catalysis of the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of the membrane to the other.','2013-10-27','NSRP'),(20579,42882,'L-arabinose transport','P','The directed movement of L-arabinose, the L-enantiomer of arabinose, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20580,42883,'cysteine transport','P','The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20581,42884,'microcin transport','P','The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20582,42885,'microcin B17 transport','P','The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20583,42886,'amide transport','P','The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20584,42887,'amide transmembrane transporter activity','F','Enables the directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other.','2013-10-27','NSRP'),(20585,42888,'molybdenum ion transmembrane transporter activity','F','Catalysis of the transfer of molybdenum (Mo) ions from one side of a membrane to the other.','2013-10-27','NSRP'),(20586,42889,'3-phenylpropionic acid transport','P','The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20587,42890,'3-phenylpropionic acid transmembrane transporter activity','F','Catalysis of the transfer of 3-phenylpropionic acid from one side of the membrane to the other.','2013-10-27','NSRP'),(20588,42891,'antibiotic transport','P','The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20589,42892,'chloramphenicol transport','P','The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20590,42893,'polymyxin transport','P','The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20591,42894,'fosmidomycin transport','P','The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20592,42895,'antibiotic transporter activity','F','Enables the directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20593,42896,'chloramphenicol transporter activity','F','Enables the directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20594,42897,'polymyxin transporter activity','F','Enables the directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20595,42898,'fosmidomycin transporter activity','F','Enables the directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20596,42899,'arabinan transport','P','The directed movement of arabinan, a polysaccharide composed of arabinose residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20597,42900,'arabinose transmembrane transporter activity','F','Catalysis of the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of the membrane to the other.','2013-10-27','NSRP'),(20598,42901,'arabinan transmembrane transporter activity','F','Catalysis of the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of the membrane to the other.','2013-10-27','NSRP'),(20599,42902,'peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein','P','The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan.','2013-10-27','NSRP'),(20600,42903,'tubulin deacetylase activity','F','Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate.','2013-10-27','NSRP'),(20601,42904,'9-cis-retinoic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative.','2013-10-27','NSRP'),(20602,42905,'9-cis-retinoic acid metabolic process','P','The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative.','2013-10-27','NSRP'),(20603,42906,'xanthine transport','P','The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids.','2013-10-27','NSRP'),(20604,42907,'xanthine transmembrane transporter activity','F','Catalysis of the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids.','2013-10-27','NSRP'),(20605,42908,'xenobiotic transport','P','The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20606,42909,'acridine transport','P','The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20607,42910,'xenobiotic transporter activity','F','Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20608,42911,'acridine transporter activity','F','Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20609,42912,'colicin transmembrane transporter activity','F','Catalysis of the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1.','2013-10-27','NSRP'),(20610,42913,'group A colicin transmembrane transporter activity','F','Catalysis of the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other.','2013-10-27','NSRP'),(20611,42914,'colicin transport','P','The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1.','2013-10-27','NSRP'),(20612,42915,'group A colicin transport','P','The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20613,42916,'alkylphosphonate transport','P','The directed movement of an alkylphosphonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20614,42917,'alkylphosphonate transmembrane transporter activity','F','Catalysis of the transfer of an alkylphosphonate from one side of a membrane to the other.','2013-10-27','NSRP'),(20615,42918,'alkanesulfonate transport','P','The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical.','2013-10-27','NSRP'),(20616,42919,'benzoate transport','P','The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20617,42920,'3-hydroxyphenylpropionic acid transport','P','The directed movement of 3-hydroxyphenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20618,42921,'glucocorticoid receptor signaling pathway','P','Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor.','2013-10-27','NSRP'),(20619,42922,'neuromedin U receptor binding','F','Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor.','2013-10-27','NSRP'),(20620,42923,'neuropeptide binding','F','Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators).','2013-10-27','NSRP'),(20621,42924,'neuromedin U binding','F','Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses.','2013-10-27','NSRP'),(20622,42925,'benzoate transporter activity','F','Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20623,42926,'3-hydroxyphenylpropionic acid transporter activity','F','Enables the directed movement of 3-hydroxyphenylpropionic acid into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20624,42927,'siderophore transporter activity','F','Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20625,42928,'ferrichrome transport','P','The directed movement of a ferrichrome into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N\'acyl-N4-hydroxy-L-ornithine.','2013-10-27','NSRP'),(20626,42929,'ferrichrome transporter activity','F','Enables the directed movement of a ferrichrome into, out of or within a cell, or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N\'acyl-N4-hydroxy-L-ornithine.','2013-10-27','NSRP'),(20627,42930,'enterobactin transport','P','The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20628,42931,'enterobactin transporter activity','F','Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20629,42932,'chrysobactin transport','P','The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20630,42933,'chrysobactin transporter activity','F','Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20631,42934,'achromobactin transporter activity','F','Enables the directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20632,42935,'achromobactin transport','P','The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20633,42936,'dipeptide transporter activity','F','Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20634,42937,'tripeptide transporter activity','F','Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20635,42938,'dipeptide transport','P','The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20636,42939,'tripeptide transport','P','The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20637,42940,'D-amino acid transport','P','The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20638,42941,'D-alanine transport','P','The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20639,42942,'D-serine transport','P','The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20640,42943,'D-amino acid transmembrane transporter activity','F','Catalysis of the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids.','2013-10-27','NSRP'),(20641,42944,'D-alanine transmembrane transporter activity','F','Catalysis of the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid.','2013-10-27','NSRP'),(20642,42945,'D-serine transmembrane transporter activity','F','Catalysis of the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid.','2013-10-27','NSRP'),(20643,42946,'glucoside transport','P','The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue.','2013-10-27','NSRP'),(20644,42947,'glucoside transmembrane transporter activity','F','Catalysis of the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue.','2013-10-27','NSRP'),(20645,42948,'salicin transport','P','The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20646,42949,'arbutin transport','P','The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20647,42950,'salicin transmembrane transporter activity','F','Catalysis of the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of the membrane to the other.','2013-10-27','NSRP'),(20648,42951,'arbutin transmembrane transporter activity','F','Catalysis of the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of the membrane to the other.','2013-10-27','NSRP'),(20649,42952,'beta-ketoadipate pathway','P','A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates.','2013-10-27','NSRP'),(20650,42953,'lipoprotein transport','P','The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20651,42954,'lipoprotein transporter activity','F','Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20652,42955,'dextrin transport','P','The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20653,42956,'maltodextrin transport','P','The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20654,42957,'dextrin transmembrane transporter activity','F','Catalysis of the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of the membrane to the other.','2013-10-27','NSRP'),(20655,42958,'maltodextrin transmembrane transporter activity','F','Catalysis of the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of the membrane to the other.','2013-10-27','NSRP'),(20656,42959,'alkanesulfonate transporter activity','F','Enables the directed movement of alkanesulfonate into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(20657,42960,'antimonite secondary active transmembrane transporter activity','F','Catalysis of the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.','2013-10-27','NSRP'),(20658,42961,'antimonite-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out).','2013-10-27','NSRP'),(20659,42962,'acridine:hydrogen antiporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out).','2013-10-27','NSRP'),(20660,42963,'phage assembly','P','A late phase of bacteriophage replication during which all the components necessary for the formation of a mature virion collect at a particular site in the bacterial cell and the basic structure of the virus particle is formed.','2012-03-14','NSRP'),(20661,42964,'thioredoxin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase.','2013-10-27','NSRP'),(20662,42965,'glutaredoxin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase.','2013-10-27','NSRP'),(20663,42966,'biotin carboxyl carrier protein biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase.','2013-10-27','NSRP'),(20664,42967,'acyl-carrier-protein biosynthetic process','P','The chemical reactions and pathways resulting in the formation of acyl-carrier protein.','2013-10-27','NSRP'),(20665,42968,'homoserine transport','P','The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20666,42969,'lactone transport','P','The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.','2013-10-27','NSRP'),(20667,42970,'homoserine transmembrane transporter activity','F','Catalysis of the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine.','2013-10-27','NSRP'),(20668,42971,'lactone transmembrane transporter activity','F','Enables the directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.','2013-10-27','NSRP'),(20669,42972,'licheninase activity','F','Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds.','2013-10-27','NSRP'),(20670,42973,'glucan endo-1,3-beta-D-glucosidase activity','F','Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans.','2013-10-27','NSRP'),(20671,42974,'retinoic acid receptor binding','F','Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.','2013-10-27','NSRP'),(20672,42975,'peroxisome proliferator activated receptor binding','F','Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma.','2013-10-27','NSRP'),(20673,42976,'activation of Janus kinase activity','P','The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.','2013-10-27','NSRP'),(20674,42977,'activation of JAK2 kinase activity','P','The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it.','2013-10-27','NSRP'),(20675,42978,'ornithine decarboxylase activator activity','F','Upregulation of the activity of the enzyme ornithine decarboxylase.','2013-10-27','NSRP'),(20676,42979,'ornithine decarboxylase regulator activity','F','Modulation of the activity of the enzyme ornithine decarboxylase.','2013-10-27','NSRP'),(20677,42980,'cystic fibrosis transmembrane conductance regulator binding','F','OBSOLETE. Interacting selectively and non-covalently with the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein.','2013-10-27','NSRP'),(20678,42981,'regulation of apoptotic process','P','Any process that modulates the occurrence or rate of cell death by apoptotic process.','2013-10-27','NSRP'),(20679,42982,'amyloid precursor protein metabolic process','P','The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer\'s disease.','2013-10-27','NSRP'),(20680,42983,'amyloid precursor protein biosynthetic process','P','The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer\'s disease.','2013-10-27','NSRP'),(20681,42984,'regulation of amyloid precursor protein biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.','2013-10-27','NSRP'),(20682,42985,'negative regulation of amyloid precursor protein biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.','2013-10-27','NSRP'),(20683,42986,'positive regulation of amyloid precursor protein biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.','2013-10-27','NSRP'),(20684,42987,'amyloid precursor protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer\'s disease.','2013-10-27','NSRP'),(20685,42988,'X11-like protein binding','F','Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein.','2013-10-27','NSRP'),(20686,42989,'sequestering of actin monomers','P','The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers.','2013-10-27','NSRP'),(20687,42990,'regulation of transcription factor import into nucleus','P','Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.','2013-10-27','NSRP'),(20688,42991,'transcription factor import into nucleus','P','The directed movement of a transcription factor from the cytoplasm to the nucleus.','2013-10-27','NSRP'),(20689,42992,'negative regulation of transcription factor import into nucleus','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.','2013-10-27','NSRP'),(20690,42993,'positive regulation of transcription factor import into nucleus','P','Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.','2013-10-27','NSRP'),(20691,42994,'cytoplasmic sequestering of transcription factor','P','The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.','2013-10-27','NSRP'),(20692,42995,'cell projection','C','A prolongation or process extending from a cell, e.g. a flagellum or axon.','2013-10-27','NSRP'),(20693,42996,'regulation of Golgi to plasma membrane protein transport','P','Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.','2013-10-27','NSRP'),(20694,42997,'negative regulation of Golgi to plasma membrane protein transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.','2013-10-27','NSRP'),(20695,42998,'positive regulation of Golgi to plasma membrane protein transport','P','Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane.','2013-10-27','NSRP'),(20696,42999,'regulation of Golgi to plasma membrane CFTR protein transport','P','Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.','2013-10-27','NSRP'),(20697,43000,'Golgi to plasma membrane CFTR protein transport','P','The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.','2013-10-27','NSRP'),(20698,43001,'Golgi to plasma membrane protein transport','P','The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.','2013-10-27','NSRP'),(20699,43002,'negative regulation of Golgi to plasma membrane CFTR protein transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.','2013-10-27','NSRP'),(20700,43003,'positive regulation of Golgi to plasma membrane CFTR protein transport','P','Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane.','2013-10-27','NSRP'),(20701,43004,'cytoplasmic sequestering of CFTR protein','P','The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane.','2013-10-27','NSRP'),(20702,43005,'neuron projection','C','A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.','2013-10-27','NSRP'),(20703,43006,'activation of phospholipase A2 activity by calcium-mediated signaling','P','A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal.','2013-10-27','NSRP'),(20704,43007,'maintenance of rDNA','P','Any process involved in sustaining the fidelity and copy number of rDNA repeats.','2013-10-27','NSRP'),(20705,43008,'ATP-dependent protein binding','F','Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP.','2013-10-27','NSRP'),(20706,43009,'chordate embryonic development','P','The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.','2013-10-27','NSRP'),(20707,43010,'camera-type eye development','P','The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.','2013-10-27','NSRP'),(20708,43011,'myeloid dendritic cell differentiation','P','The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin.','2013-10-27','NSRP'),(20709,43012,'regulation of fusion of sperm to egg plasma membrane','P','Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane.','2013-10-27','NSRP'),(20710,43013,'negative regulation of fusion of sperm to egg plasma membrane','P','Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane.','2013-10-27','NSRP'),(20711,43014,'alpha-tubulin binding','F','Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.','2013-10-27','NSRP'),(20712,43015,'gamma-tubulin binding','F','Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin.','2013-10-27','NSRP'),(20713,43016,'regulation of lymphotoxin A biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A.','2013-10-27','NSRP'),(20714,43017,'positive regulation of lymphotoxin A biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A.','2013-10-27','NSRP'),(20715,43018,'negative regulation of lymphotoxin A biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A.','2013-10-27','NSRP'),(20716,43020,'NADPH oxidase complex','C','A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.','2013-10-27','NSRP'),(20717,43021,'ribonucleoprotein complex binding','F','Interacting selectively and non-covalently with any complex of RNA and protein.','2013-10-27','NSRP'),(20718,43022,'ribosome binding','F','Interacting selectively and non-covalently with any part of a ribosome.','2013-10-27','NSRP'),(20719,43023,'ribosomal large subunit binding','F','Interacting selectively and non-covalently with any part of the larger ribosomal subunit.','2013-10-27','NSRP'),(20720,43024,'ribosomal small subunit binding','F','Interacting selectively and non-covalently with any part of the small ribosomal subunit.','2013-10-27','NSRP'),(20721,43025,'neuronal cell body','C','The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.','2013-10-27','NSRP'),(20722,43027,'cysteine-type endopeptidase inhibitor activity involved in apoptotic process','F','Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.','2013-10-27','NSRP'),(20723,43028,'cysteine-type endopeptidase regulator activity involved in apoptotic process','F','Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process.','2013-10-27','NSRP'),(20724,43029,'T cell homeostasis','P','The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.','2013-10-27','NSRP'),(20725,43030,'regulation of macrophage activation','P','Any process that modulates the frequency or rate of macrophage activation.','2013-10-27','NSRP'),(20726,43031,'negative regulation of macrophage activation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.','2013-10-27','NSRP'),(20727,43032,'positive regulation of macrophage activation','P','Any process that stimulates, induces or increases the rate of macrophage activation.','2013-10-27','NSRP'),(20728,43033,'isoamylase complex','C','A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages.','2013-10-27','NSRP'),(20729,43034,'costamere','C','Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix.','2013-10-27','NSRP'),(20730,43035,'chromatin insulator sequence binding','F','Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription.','2013-10-27','NSRP'),(20731,43036,'starch grain','C','Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped.','2013-10-27','NSRP'),(20732,43038,'amino acid activation','P','The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule.','2013-10-27','NSRP'),(20733,43039,'tRNA aminoacylation','P','The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3\'-hydroxyl group of the most 3\' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.','2013-10-27','NSRP'),(20734,43040,'tRNA aminoacylation for nonribosomal peptide biosynthetic process','P','The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3\'-hydroxyl group of the most 3\' adenosine of the tRNA, to be used in nonribosomal peptide synthesis.','2013-10-27','NSRP'),(20735,43041,'amino acid activation for nonribosomal peptide biosynthetic process','P','Activation of an amino acid for incorporation into a peptide by a nonribosomal process.','2013-10-27','NSRP'),(20736,43042,'amino acid adenylylation by nonribosomal peptide synthase','P','Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor.','2013-10-27','NSRP'),(20737,43043,'peptide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide.','2013-10-27','NSRP'),(20738,43044,'ATP-dependent chromatin remodeling','P','Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors.','2013-10-27','NSRP'),(20739,43045,'DNA methylation involved in embryo development','P','The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression.','2013-10-27','NSRP'),(20740,43046,'DNA methylation involved in gamete generation','P','The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.','2013-10-27','NSRP'),(20741,43047,'single-stranded telomeric DNA binding','F','Interacting selectively and non-covalently with single-stranded telomere-associated DNA.','2013-10-27','NSRP'),(20742,43048,'dolichyl monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative.','2013-10-27','NSRP'),(20743,43049,'otic placode formation','P','The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain.','2013-10-27','NSRP'),(20744,43050,'pharyngeal pumping','P','The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes.','2013-10-27','NSRP'),(20745,43051,'regulation of pharyngeal pumping','P','Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes.','2013-10-27','NSRP'),(20746,43052,'thermotaxis','P','The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.','2013-10-27','NSRP'),(20747,43053,'dauer entry','P','Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development.','2013-10-27','NSRP'),(20748,43054,'dauer exit','P','Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development.','2013-10-27','NSRP'),(20749,43055,'maintenance of dauer','P','Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development.','2013-10-27','NSRP'),(20750,43056,'forward locomotion','P','Anterior movement of an organism, following the direction of the head of the animal.','2013-10-27','NSRP'),(20751,43057,'backward locomotion','P','Posterior movement of an organism, e.g. following the direction of the tail of an animal.','2013-10-27','NSRP'),(20752,43058,'regulation of backward locomotion','P','Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism.','2013-10-27','NSRP'),(20753,43059,'regulation of forward locomotion','P','Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism.','2013-10-27','NSRP'),(20754,43060,'meiotic metaphase I plate congression','P','The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I.','2013-10-27','NSRP'),(20755,43061,'meiotic metaphase II plate congression','P','The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II.','2013-10-27','NSRP'),(20756,43062,'extracellular structure organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite.','2013-10-27','NSRP'),(20757,43063,'intercellular bridge organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another.','2013-10-27','NSRP'),(20758,43064,'flagellum organization','P','OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement.','2013-10-27','NSRP'),(20759,43065,'positive regulation of apoptotic process','P','Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.','2013-10-27','NSRP'),(20760,43066,'negative regulation of apoptotic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.','2013-10-27','NSRP'),(20761,43067,'regulation of programmed cell death','P','Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.','2013-10-27','NSRP'),(20762,43068,'positive regulation of programmed cell death','P','Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.','2013-10-27','NSRP'),(20763,43069,'negative regulation of programmed cell death','P','Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.','2013-10-27','NSRP'),(20764,43073,'germ cell nucleus','C','The nucleus of a germ cell, a reproductive cell in multicellular organisms.','2013-10-27','NSRP'),(20765,43075,'sperm cell nucleus (sensu Magnoliophyta)','C','OBSOLETE. The nucleus of a plant pollen cell, the male gamete, and its descendents.','2013-10-27','NSRP'),(20766,43076,'megasporocyte nucleus','C','The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents.','2013-10-27','NSRP'),(20767,43077,'initiation of acetate catabolic process','P','The activation of the chemical reactions and pathways resulting in the breakdown of acetate.','2013-10-27','NSRP'),(20768,43078,'polar nucleus','C','Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus.','2013-10-27','NSRP'),(20769,43079,'antipodal cell nucleus','C','The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents.','2013-10-27','NSRP'),(20770,43082,'megagametophyte egg cell nucleus','C','The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo.','2013-10-27','NSRP'),(20771,43083,'synaptic cleft','C','The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released.','2013-10-27','NSRP'),(20772,43084,'penile erection','P','The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow.','2013-10-27','NSRP'),(20773,43085,'positive regulation of catalytic activity','P','Any process that activates or increases the activity of an enzyme.','2013-10-27','NSRP'),(20774,43086,'negative regulation of catalytic activity','P','Any process that stops or reduces the activity of an enzyme.','2013-10-27','NSRP'),(20775,43087,'regulation of GTPase activity','P','Any process that modulates the rate of GTP hydrolysis by a GTPase.','2013-10-27','NSRP'),(20776,43088,'regulation of Cdc42 GTPase activity','P','Any process that modulates the activity of the GTPase Cdc42.','2013-10-27','NSRP'),(20777,43089,'positive regulation of Cdc42 GTPase activity','P','Any process that activates or increases the activity of the GTPase Cdc42.','2013-10-27','NSRP'),(20778,43090,'amino acid import','P','The directed movement of amino acids into a cell or organelle.','2013-10-27','NSRP'),(20779,43091,'L-arginine import','P','The directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle.','2013-10-27','NSRP'),(20780,43092,'L-amino acid import','P','The directed movement of L-enantiomer amino acids into a cell or organelle.','2013-10-27','NSRP'),(20781,43093,'cytokinesis by binary fission','P','A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells; the process in which prokaryotic cells divide.','2013-10-27','NSRP'),(20782,43094,'cellular metabolic compound salvage','P','Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells.','2013-10-27','NSRP'),(20783,43095,'regulation of GTP cyclohydrolase I activity','P','Any process that modulates the activity of the enzyme GTP cyclohydrolase I.','2013-10-27','NSRP'),(20784,43096,'purine nucleobase salvage','P','Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis.','2013-10-27','NSRP'),(20785,43097,'pyrimidine nucleoside salvage','P','Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(20786,43098,'purine deoxyribonucleoside salvage','P','Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(20787,43099,'pyrimidine deoxyribonucleoside salvage','P','Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(20788,43100,'pyrimidine nucleobase salvage','P','Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis.','2013-10-27','NSRP'),(20789,43101,'purine-containing compound salvage','P','Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis.','2013-10-27','NSRP'),(20790,43102,'amino acid salvage','P','Any process which produces an amino acid from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(20791,43103,'hypoxanthine salvage','P','Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis.','2013-10-27','NSRP'),(20792,43104,'positive regulation of GTP cyclohydrolase I activity','P','Any process that activates or increases the activity of the enzyme GTP cyclohydrolase I.','2013-10-27','NSRP'),(20793,43105,'negative regulation of GTP cyclohydrolase I activity','P','Any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I.','2013-10-27','NSRP'),(20794,43106,'GTP cyclohydrolase I binding','F','Interacting selectively and non-covalently with the enzyme GTP cyclohydrolase I.','2012-03-14','NSRP'),(20795,43107,'type IV pilus-dependent motility','P','Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility.','2013-10-27','NSRP'),(20796,43108,'pilus retraction','P','The process of withdrawing a pilus back into a cell.','2013-10-27','NSRP'),(20797,43110,'rDNA spacer replication fork barrier binding','F','Interacting selectively and non-covalently with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription.','2013-10-27','NSRP'),(20798,43111,'replication fork arrest','P','Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork.','2013-10-27','NSRP'),(20799,43112,'receptor metabolic process','P','The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.','2013-10-27','NSRP'),(20800,43113,'receptor clustering','P','The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.','2013-10-27','NSRP'),(20801,43114,'regulation of vascular permeability','P','Any process that modulates the extent to which blood vessels can be pervaded by fluid.','2013-10-27','NSRP'),(20802,43115,'precorrin-2 dehydrogenase activity','F','Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin.','2013-10-27','NSRP'),(20803,43116,'negative regulation of vascular permeability','P','Any process that reduces the extent to which blood vessels can be pervaded by fluid.','2013-10-27','NSRP'),(20804,43117,'positive regulation of vascular permeability','P','Any process that increases the extent to which blood vessels can be pervaded by fluid.','2013-10-27','NSRP'),(20805,43120,'tumor necrosis factor binding','F','Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages.','2013-10-27','NSRP'),(20806,43121,'neurotrophin binding','F','Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.','2013-10-27','NSRP'),(20807,43122,'regulation of I-kappaB kinase/NF-kappaB cascade','P','Any process that modulates an I-kappaB kinase/NF-kappaB induced cascade.','2013-10-27','NSRP'),(20808,43123,'positive regulation of I-kappaB kinase/NF-kappaB cascade','P','Any process that activates or increases the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.','2013-10-27','NSRP'),(20809,43124,'negative regulation of I-kappaB kinase/NF-kappaB cascade','P','Any process that stops, prevents, or reduces the frequency, rate or extent of an I-kappaB kinase/NF-kappaB induced cascade.','2013-10-27','NSRP'),(20810,43125,'ErbB-3 class receptor binding','F','Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3.','2013-10-27','NSRP'),(20811,43126,'regulation of 1-phosphatidylinositol 4-kinase activity','P','Any process that modulates the activity of the enzyme 1-phosphatidylinositol 4-kinase.','2013-10-27','NSRP'),(20812,43127,'negative regulation of 1-phosphatidylinositol 4-kinase activity','P','Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase.','2013-10-27','NSRP'),(20813,43128,'positive regulation of 1-phosphatidylinositol 4-kinase activity','P','Any process that activates or increases the activity of 1-phosphatidylinositol 4-kinase.','2013-10-27','NSRP'),(20814,43129,'surfactant homeostasis','P','Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.','2013-10-27','NSRP'),(20815,43130,'ubiquitin binding','F','Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.','2013-10-27','NSRP'),(20816,43131,'enucleation','P','The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation.','2013-10-27','NSRP'),(20817,43132,'NAD transport','P','The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH.','2013-10-27','NSRP'),(20818,43133,'hindgut contraction','P','A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine.','2013-10-27','NSRP'),(20819,43134,'regulation of hindgut contraction','P','Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine.','2013-10-27','NSRP'),(20820,43135,'5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity','F','Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+.','2013-10-27','NSRP'),(20821,43136,'glycerol-3-phosphatase activity','F','Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.','2013-10-27','NSRP'),(20822,43137,'DNA replication, removal of RNA primer','P','Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease.','2013-10-27','NSRP'),(20823,43138,'3\'-5\' DNA helicase activity','F','Catalysis of the unwinding of the DNA helix in the direction 3\' to 5\'.','2013-10-27','NSRP'),(20824,43139,'5\'-3\' DNA helicase activity','F','Catalysis of the unwinding of the DNA helix in the direction 5\' to 3\'.','2013-10-27','NSRP'),(20825,43140,'ATP-dependent 3\'-5\' DNA helicase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3\' to 5\'.','2013-10-27','NSRP'),(20826,43141,'ATP-dependent 5\'-3\' DNA helicase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5\' to 3\'.','2013-10-27','NSRP'),(20827,43142,'single-stranded DNA-dependent ATPase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction.','2013-10-27','NSRP'),(20828,43143,'regulation of translation by machinery localization','P','Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location.','2013-10-27','NSRP'),(20829,43144,'snoRNA processing','P','Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA.','2013-10-27','NSRP'),(20830,43145,'snoRNA 3\'-end cleavage','P','The endonucleolytic cleavage of snoRNA 3\' ends, which is required for mature snoRNAs to be functional.','2013-10-27','NSRP'),(20831,43146,'spindle stabilization','P','Any process involved in maintaining the structure and integrity of the spindle.','2013-10-27','NSRP'),(20832,43147,'meiotic spindle stabilization','P','The cell cycle process in which spindle integrity is maintained during M phase of meiosis.','2013-10-27','NSRP'),(20833,43148,'mitotic spindle stabilization','P','The cell cycle process in which spindle integrity is maintained during M phase of mitosis.','2013-10-27','NSRP'),(20834,43149,'stress fiber assembly','P','The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity.','2013-10-27','NSRP'),(20835,43150,'DNA synthesis involved in double-strand break repair via homologous recombination','P','The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination.','2013-10-27','NSRP'),(20836,43151,'DNA synthesis involved in double-strand break repair via single-strand annealing','P','The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing.','2013-10-27','NSRP'),(20837,43152,'induction of bacterial agglutination','P','Any process in which infecting bacteria are clumped together by a host organism.','2013-10-27','NSRP'),(20838,43153,'entrainment of circadian clock by photoperiod','P','The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night).','2013-10-27','NSRP'),(20839,43154,'negative regulation of cysteine-type endopeptidase activity involved in apoptotic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.','2013-10-27','NSRP'),(20840,43155,'negative regulation of photosynthesis, light reaction','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis.','2013-10-27','NSRP'),(20841,43156,'chromatin remodeling in response to cation stress','P','Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment.','2013-10-27','NSRP'),(20842,43157,'response to cation stress','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment.','2013-10-27','NSRP'),(20843,43158,'heterocyst differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen.','2013-10-27','NSRP'),(20844,43159,'acrosomal matrix','C','A structural framework, or \'dense core\' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction.','2013-10-27','NSRP'),(20845,43160,'acrosomal lumen','C','The volume enclosed within the acrosome membrane.','2013-10-27','NSRP'),(20846,43161,'proteasomal ubiquitin-dependent protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.','2013-10-27','NSRP'),(20847,43162,'ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway','P','The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.','2013-10-27','NSRP'),(20848,43163,'cell envelope organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present.','2013-10-27','NSRP'),(20849,43164,'Gram-negative-bacterium-type cell wall biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane.','2013-10-27','NSRP'),(20850,43165,'Gram-negative-bacterium-type cell outer membrane assembly','P','The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.','2013-10-27','NSRP'),(20851,43167,'ion binding','F','Interacting selectively and non-covalently with ions, charged atoms or groups of atoms.','2013-10-27','NSRP'),(20852,43168,'anion binding','F','Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge.','2013-10-27','NSRP'),(20853,43169,'cation binding','F','Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge.','2013-10-27','NSRP'),(20854,43170,'macromolecule metabolic process','P','The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.','2013-10-27','NSRP'),(20855,43171,'peptide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.','2013-10-27','NSRP'),(20856,43172,'ferredoxin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each.','2013-10-27','NSRP'),(20857,43173,'nucleotide salvage','P','Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis.','2013-10-27','NSRP'),(20858,43174,'nucleoside salvage','P','Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis.','2013-10-27','NSRP'),(20859,43175,'RNA polymerase core enzyme binding','F','Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme.','2013-10-27','NSRP'),(20860,43176,'amine binding','F','Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group.','2013-10-27','NSRP'),(20861,43177,'organic acid binding','F','Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage.','2013-10-27','NSRP'),(20862,43178,'alcohol binding','F','Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group.','2013-10-27','NSRP'),(20863,43179,'rhythmic excitation','P','Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit.','2013-10-27','NSRP'),(20864,43180,'rhythmic inhibition','P','Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit.','2013-10-27','NSRP'),(20865,43181,'vacuolar sequestering','P','The process of transporting a substance into, and confining within, a vacuole.','2013-10-27','NSRP'),(20866,43182,'vacuolar sequestering of sodium ion','P','The process of transporting sodium ions into, and confining within, a vacuole.','2013-10-27','NSRP'),(20867,43183,'vascular endothelial growth factor receptor 1 binding','F','Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1.','2013-10-27','NSRP'),(20868,43184,'vascular endothelial growth factor receptor 2 binding','F','Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2.','2013-10-27','NSRP'),(20869,43185,'vascular endothelial growth factor receptor 3 binding','F','Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3.','2013-10-27','NSRP'),(20870,43186,'P granule','C','A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.','2013-10-27','NSRP'),(20871,43187,'cell septum surface','C','The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe.','2013-10-27','NSRP'),(20872,43188,'cell septum edging','C','The cell wall material that surrounds the septum in fungal cells.','2013-10-27','NSRP'),(20873,43189,'H4/H2A histone acetyltransferase complex','C','A multisubunit complex that catalyzes the acetylation of histones H4 and H2A.','2013-10-27','NSRP'),(20874,43190,'ATP-binding cassette (ABC) transporter complex','C','A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.','2013-10-27','NSRP'),(20875,43194,'axon initial segment','C','Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.','2013-10-27','NSRP'),(20876,43195,'terminal bouton','C','Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.','2013-10-27','NSRP'),(20877,43196,'varicosity','C','Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters.','2013-10-27','NSRP'),(20878,43197,'dendritic spine','C','Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.','2013-10-27','NSRP'),(20879,43198,'dendritic shaft','C','Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.','2013-10-27','NSRP'),(20880,43199,'sulfate binding','F','Interacting selectively and non-covalently with sulfate, SO4(2-), a negatively charged small molecule.','2013-10-27','NSRP'),(20881,43200,'response to amino acid stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.','2013-10-27','NSRP'),(20882,43201,'response to leucine','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.','2013-10-27','NSRP'),(20883,43202,'lysosomal lumen','C','The volume enclosed within the lysosomal membrane.','2013-10-27','NSRP'),(20884,43203,'axon hillock','C','Portion of the neuronal cell soma from which the axon originates.','2013-10-27','NSRP'),(20885,43204,'perikaryon','C','The portion of the cell soma (cell body) that excludes the nucleus.','2013-10-27','NSRP'),(20886,43205,'fibril','C','Extracellular matrix material consisting of polysaccharides and protein.','2013-10-27','NSRP'),(20887,43206,'extracellular fibril organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins.','2013-10-27','NSRP'),(20888,43207,'response to external biotic stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things.','2013-10-27','NSRP'),(20889,43208,'glycosphingolipid binding','F','Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.','2013-10-27','NSRP'),(20890,43209,'myelin sheath','C','An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.','2013-10-27','NSRP'),(20891,43210,'alkanesulfonate binding','F','Interacting selectively and non-covalently with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group.','2013-10-27','NSRP'),(20892,43211,'carbohydrate-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane.','2013-10-27','NSRP'),(20893,43212,'carbohydrate-exporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out).','2013-10-27','NSRP'),(20894,43213,'bacteriocin transport','P','The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain.','2013-10-27','NSRP'),(20895,43214,'bacteriocin-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of bacteriocins across a membrane.','2013-10-27','NSRP'),(20896,43215,'daunorubicin transport','P','The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20897,43216,'daunorubicin-transporting ATPase activity','F','Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out).','2013-10-27','NSRP'),(20898,43217,'myelin maintenance','P','The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath.','2013-10-27','NSRP'),(20899,43218,'compact myelin','C','The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.','2013-10-27','NSRP'),(20900,43219,'lateral loop','C','Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.','2013-10-27','NSRP'),(20901,43220,'Schmidt-Lanterman incisure','C','Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier.','2013-10-27','NSRP'),(20902,43221,'SMC family protein binding','F','Interacting selectively and non-covalently with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization.','2013-10-27','NSRP'),(20903,43223,'cytoplasmic SCF ubiquitin ligase complex','C','A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).','2013-10-27','NSRP'),(20904,43224,'nuclear SCF ubiquitin ligase complex','C','A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).','2013-10-27','NSRP'),(20905,43225,'anion transmembrane-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in).','2013-10-27','NSRP'),(20906,43226,'organelle','C','Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.','2013-10-27','NSRP'),(20907,43227,'membrane-bounded organelle','C','Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.','2013-10-27','NSRP'),(20908,43228,'non-membrane-bounded organelle','C','Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes.','2013-10-27','NSRP'),(20909,43229,'intracellular organelle','C','Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.','2013-10-27','NSRP'),(20910,43230,'extracellular organelle','C','Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.','2013-10-27','NSRP'),(20911,43231,'intracellular membrane-bounded organelle','C','Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.','2013-10-27','NSRP'),(20912,43232,'intracellular non-membrane-bounded organelle','C','Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes.','2013-10-27','NSRP'),(20913,43233,'organelle lumen','C','The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen.','2013-10-27','NSRP'),(20914,43234,'protein complex','C','Any macromolecular complex composed of two or more polypeptide subunits, which may or may not be identical. Protein complexes may have other associated non-protein prosthetic groups, such as nucleotides, metal ions or other small molecules.','2013-10-27','NSRP'),(20915,43235,'receptor complex','C','Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.','2013-10-27','NSRP'),(20916,43236,'laminin binding','F','Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.','2013-10-27','NSRP'),(20917,43237,'laminin-1 binding','F','Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1.','2013-10-27','NSRP'),(20918,43238,'laminin-2 binding','F','Interacting selectively and non-covalently with laminin-2, a glycoprotein trimer with the subunit composition alpha2, beta1, gamma 1.','2012-03-14','NSRP'),(20919,43239,'laminin-4 binding','F','Interacting selectively and non-covalently with laminin-4, a glycoprotein trimer with the subunit composition alpha2, beta2, gamma 1.','2012-03-14','NSRP'),(20920,43240,'Fanconi anaemia nuclear complex','C','A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage.','2013-10-27','NSRP'),(20921,43241,'protein complex disassembly','P','The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.','2013-10-27','NSRP'),(20922,43242,'negative regulation of protein complex disassembly','P','Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.','2013-10-27','NSRP'),(20923,43243,'positive regulation of protein complex disassembly','P','Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.','2013-10-27','NSRP'),(20924,43244,'regulation of protein complex disassembly','P','Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.','2013-10-27','NSRP'),(20925,43245,'extraorganismal space','C','The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms.','2013-10-27','NSRP'),(20926,43246,'megasome','C','Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex.','2013-10-27','NSRP'),(20927,43247,'telomere maintenance in response to DNA damage','P','Any process that occur in response to the presence of critically short telomeres.','2013-10-27','NSRP'),(20928,43248,'proteasome assembly','P','The aggregation, arrangement and bonding together of a mature, active proteasome complex.','2013-10-27','NSRP'),(20929,43249,'erythrocyte maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state.','2013-10-27','NSRP'),(20930,43250,'sodium-dependent organic anion transmembrane transporter activity','F','Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner.','2013-10-27','NSRP'),(20931,43251,'sodium-dependent organic anion transport','P','The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20932,43252,'sodium-independent organic anion transport','P','The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20933,43253,'chloroplast ribosome','C','A ribosome contained within a chloroplast.','2013-10-27','NSRP'),(20934,43254,'regulation of protein complex assembly','P','Any process that modulates the frequency, rate or extent of protein complex assembly.','2013-10-27','NSRP'),(20935,43255,'regulation of carbohydrate biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates.','2013-10-27','NSRP'),(20936,43256,'laminin complex','C','A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes.','2013-10-27','NSRP'),(20937,43257,'laminin-8 complex','C','A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains.','2013-10-27','NSRP'),(20938,43258,'laminin-9 complex','C','A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains.','2013-10-27','NSRP'),(20939,43259,'laminin-10 complex','C','A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains.','2013-10-27','NSRP'),(20940,43260,'laminin-11 complex','C','A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains.','2013-10-27','NSRP'),(20941,43261,'laminin-12 complex','C','A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains.','2013-10-27','NSRP'),(20942,43262,'adenosine-diphosphatase activity','F','Catalysis of the reaction: ADP + H2O = AMP + phosphate.','2013-10-27','NSRP'),(20943,43263,'cellulosome','C','An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose.','2013-10-27','NSRP'),(20944,43264,'extracellular non-membrane-bounded organelle','C','Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell.','2013-10-27','NSRP'),(20945,43265,'ectoplasm','C','Granule free cytoplasm, lying immediately below the plasma membrane.','2013-10-27','NSRP'),(20946,43266,'regulation of potassium ion transport','P','Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20947,43267,'negative regulation of potassium ion transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20948,43268,'positive regulation of potassium ion transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20949,43269,'regulation of ion transport','P','Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20950,43270,'positive regulation of ion transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20951,43271,'negative regulation of ion transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(20952,43272,'ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance','P','The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance.','2013-10-27','NSRP'),(20953,43273,'CTPase activity','F','Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction.','2013-10-27','NSRP'),(20954,43274,'phospholipase binding','F','Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.','2013-10-27','NSRP'),(20955,43275,'glutamate carboxypeptidase II activity','F','OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu.','2013-10-27','NSRP'),(20956,43276,'anoikis','P','Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.','2013-10-27','NSRP'),(20957,43277,'apoptotic cell clearance','P','The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.','2013-10-27','NSRP'),(20958,43278,'response to morphine','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.','2013-10-27','NSRP'),(20959,43279,'response to alkaloid','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active.','2013-10-27','NSRP'),(20960,43280,'positive regulation of cysteine-type endopeptidase activity involved in apoptotic process','P','Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.','2013-10-27','NSRP'),(20961,43281,'regulation of cysteine-type endopeptidase activity involved in apoptotic process','P','Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis.','2013-10-27','NSRP'),(20962,43282,'pharyngeal muscle development','P','The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx.','2013-10-27','NSRP'),(20963,43286,'regulation of poly(3-hydroxyalkanoate) biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria.','2013-10-27','NSRP'),(20964,43287,'poly(3-hydroxyalkanoate) binding','F','Interacting selectively and non-covalently with poly(3-hydroxyalkanoate)s, polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria.','2013-10-27','NSRP'),(20965,43288,'apocarotenoid metabolic process','P','The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid.','2013-10-27','NSRP'),(20966,43289,'apocarotenoid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid.','2013-10-27','NSRP'),(20967,43290,'apocarotenoid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid.','2013-10-27','NSRP'),(20968,43291,'RAVE complex','C','A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme.','2013-10-27','NSRP'),(20969,43292,'contractile fiber','C','Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.','2013-10-27','NSRP'),(20970,43293,'apoptosome','C','A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms.','2013-10-27','NSRP'),(20971,43294,'mitochondrial glutamate synthase complex (NADH)','C','A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.','2013-10-27','NSRP'),(20972,43295,'glutathione binding','F','Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine.','2013-10-27','NSRP'),(20973,43296,'apical junction complex','C','A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.','2013-10-27','NSRP'),(20974,43297,'apical junction assembly','P','The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents.','2013-10-27','NSRP'),(20975,43299,'leukocyte degranulation','P','The regulated exocytosis of secretory granules by a leukocyte.','2013-10-27','NSRP'),(20976,43300,'regulation of leukocyte degranulation','P','Any process that modulates the frequency, rate, or extent of leukocyte degranulation.','2013-10-27','NSRP'),(20977,43301,'negative regulation of leukocyte degranulation','P','Any process that stops, prevents, or reduces the rate of leukocyte degranulation.','2013-10-27','NSRP'),(20978,43302,'positive regulation of leukocyte degranulation','P','Any process that activates or increases the frequency, rate or extent of leukocyte degranulation.','2013-10-27','NSRP'),(20979,43303,'mast cell degranulation','P','The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.','2013-10-27','NSRP'),(20980,43304,'regulation of mast cell degranulation','P','Any process that modulates the frequency, rate, or extent of mast cell degranulation.','2013-10-27','NSRP'),(20981,43305,'negative regulation of mast cell degranulation','P','Any process that stops, prevents, or reduces the rate of mast cell degranulation.','2013-10-27','NSRP'),(20982,43306,'positive regulation of mast cell degranulation','P','Any process that activates or increases the frequency, rate or extent of mast cell degranulation.','2013-10-27','NSRP'),(20983,43307,'eosinophil activation','P','The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(20984,43308,'eosinophil degranulation','P','The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil.','2013-10-27','NSRP'),(20985,43309,'regulation of eosinophil degranulation','P','Any process that modulates the frequency, rate, or extent of eosinophil degranulation.','2013-10-27','NSRP'),(20986,43310,'negative regulation of eosinophil degranulation','P','Any process that stops, prevents, or reduces the rate of eosinophil degranulation.','2013-10-27','NSRP'),(20987,43311,'positive regulation of eosinophil degranulation','P','Any process that activates or increases the frequency, rate or extent of eosinophil degranulation.','2013-10-27','NSRP'),(20988,43312,'neutrophil degranulation','P','The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.','2013-10-27','NSRP'),(20989,43313,'regulation of neutrophil degranulation','P','Any process that modulates the frequency, rate, or extent of neutrophil degranulation.','2013-10-27','NSRP'),(20990,43314,'negative regulation of neutrophil degranulation','P','Any process that stops, prevents, or reduces the rate of neutrophil degranulation.','2013-10-27','NSRP'),(20991,43315,'positive regulation of neutrophil degranulation','P','Any process that activates or increases the frequency, rate or extent of neutrophil degranulation.','2013-10-27','NSRP'),(20992,43316,'cytotoxic T cell degranulation','P','The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell.','2013-10-27','NSRP'),(20993,43317,'regulation of cytotoxic T cell degranulation','P','Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation.','2013-10-27','NSRP'),(20994,43318,'negative regulation of cytotoxic T cell degranulation','P','Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation.','2013-10-27','NSRP'),(20995,43319,'positive regulation of cytotoxic T cell degranulation','P','Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation.','2013-10-27','NSRP'),(20996,43320,'natural killer cell degranulation','P','The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.','2013-10-27','NSRP'),(20997,43321,'regulation of natural killer cell degranulation','P','Any process that modulates the frequency, rate, or extent of natural killer cell degranulation.','2013-10-27','NSRP'),(20998,43322,'negative regulation of natural killer cell degranulation','P','Any process that stops, prevents, or reduces the rate of natural killer cell degranulation.','2013-10-27','NSRP'),(20999,43323,'positive regulation of natural killer cell degranulation','P','Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation.','2013-10-27','NSRP'),(21000,43324,'pigment metabolic process involved in developmental pigmentation','P','The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism.','2013-10-27','NSRP'),(21001,43325,'phosphatidylinositol-3,4-bisphosphate binding','F','Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3\' and 4\' positions.','2013-10-27','NSRP'),(21002,43326,'chemotaxis to folate','P','The directed movement of a motile cell or organism in response to the presence of folate.','2013-10-27','NSRP'),(21003,43327,'chemotaxis to cAMP','P','The directed movement of a motile cell or organism in response to the presence of 3\',5\'-cAMP.','2013-10-27','NSRP'),(21004,43328,'protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway','P','The process of directing proteins towards the vacuole using signals contained within the protein, occurring that contributes to protein catabolism via the multivesicular body (MVB) pathway.','2013-10-27','NSRP'),(21005,43329,'protein targeting to membrane involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway','P','The process of directing proteins towards a membrane using signals contained within the protein, occurring that contributes to ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway.','2013-10-27','NSRP'),(21006,43330,'response to exogenous dsRNA','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.','2013-10-27','NSRP'),(21007,43331,'response to dsRNA','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus.','2013-10-27','NSRP'),(21008,43332,'mating projection tip','C','The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.','2013-10-27','NSRP'),(21009,43333,'2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity','F','Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(21010,43334,'2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity','F','Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(21011,43335,'protein unfolding','P','The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state.','2013-10-27','NSRP'),(21012,43336,'site-specific telomere resolvase activity','F','Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases.','2013-10-27','NSRP'),(21013,43337,'CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity','F','Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol.','2013-10-27','NSRP'),(21014,43338,'CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity','F','Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol.','2013-10-27','NSRP'),(21015,43353,'enucleate erythrocyte differentiation','P','The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(21016,43354,'enucleate erythrocyte maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus.','2013-10-27','NSRP'),(21017,43362,'nucleate erythrocyte maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus.','2013-10-27','NSRP'),(21018,43363,'nucleate erythrocyte differentiation','P','The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds.','2013-10-27','NSRP'),(21019,43364,'catalysis of free radical formation','F','Catalysis of a reaction that generates a free radical, a highly reactive molecule with an unsatisfied electron valence pair.','2013-10-27','NSRP'),(21020,43365,'[formate-C-acetyltransferase]-activating enzyme activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5\'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical.','2013-10-27','NSRP'),(21021,43366,'beta selection','P','The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell.','2013-10-27','NSRP'),(21022,43367,'CD4-positive, alpha-beta T cell differentiation','P','The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell.','2013-10-27','NSRP'),(21023,43368,'positive T cell selection','P','The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.','2013-10-27','NSRP'),(21024,43369,'CD4-positive or CD8-positive, alpha-beta T cell lineage commitment','P','The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells.','2013-10-27','NSRP'),(21025,43370,'regulation of CD4-positive, alpha-beta T cell differentiation','P','Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.','2013-10-27','NSRP'),(21026,43371,'negative regulation of CD4-positive, alpha-beta T cell differentiation','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.','2013-10-27','NSRP'),(21027,43372,'positive regulation of CD4-positive, alpha-beta T cell differentiation','P','Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation.','2013-10-27','NSRP'),(21028,43373,'CD4-positive, alpha-beta T cell lineage commitment','P','The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell.','2013-10-27','NSRP'),(21029,43374,'CD8-positive, alpha-beta T cell differentiation','P','The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell.','2013-10-27','NSRP'),(21030,43375,'CD8-positive, alpha-beta T cell lineage commitment','P','The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell.','2013-10-27','NSRP'),(21031,43376,'regulation of CD8-positive, alpha-beta T cell differentiation','P','Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation.','2013-10-27','NSRP'),(21032,43377,'negative regulation of CD8-positive, alpha-beta T cell differentiation','P','Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation.','2013-10-27','NSRP'),(21033,43378,'positive regulation of CD8-positive, alpha-beta T cell differentiation','P','Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation.','2013-10-27','NSRP'),(21034,43379,'memory T cell differentiation','P','The process in which a newly activated T cell acquires specialized features of a memory T cell.','2013-10-27','NSRP'),(21035,43380,'regulation of memory T cell differentiation','P','Any process that modulates the frequency, rate, or extent of memory T cell differentiation.','2013-10-27','NSRP'),(21036,43381,'negative regulation of memory T cell differentiation','P','Any process that stops, prevents, or reduces the rate of memory T cell differentiation.','2013-10-27','NSRP'),(21037,43382,'positive regulation of memory T cell differentiation','P','Any process that activates or increases the frequency, rate or extent of memory T cell differentiation.','2013-10-27','NSRP'),(21038,43383,'negative T cell selection','P','The process of elimination of immature T cells which react strongly with self-antigens.','2013-10-27','NSRP'),(21039,43384,'pre-T cell receptor complex','C','A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins.','2013-10-27','NSRP'),(21040,43385,'mycotoxin metabolic process','P','The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus.','2013-10-27','NSRP'),(21041,43386,'mycotoxin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus.','2013-10-27','NSRP'),(21042,43387,'mycotoxin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus.','2013-10-27','NSRP'),(21043,43388,'positive regulation of DNA binding','P','Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).','2013-10-27','NSRP'),(21044,43390,'aflatoxin B1 metabolic process','P','The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi.','2013-10-27','NSRP'),(21045,43391,'aflatoxin B2 metabolic process','P','The chemical reactions and pathways involving aflatoxin B2, a mycotoxin produced by the fungal species Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius.','2013-10-27','NSRP'),(21046,43392,'negative regulation of DNA binding','P','Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).','2013-10-27','NSRP'),(21047,43393,'regulation of protein binding','P','Any process that modulates the frequency, rate or extent of protein binding.','2013-10-27','NSRP'),(21048,43394,'proteoglycan binding','F','Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans.','2013-10-27','NSRP'),(21049,43395,'heparan sulfate proteoglycan binding','F','Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.','2013-10-27','NSRP'),(21050,43396,'corticotropin-releasing hormone secretion','P','The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle.','2013-10-27','NSRP'),(21051,43397,'regulation of corticotropin-releasing hormone secretion','P','Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion.','2013-10-27','NSRP'),(21052,43398,'HLH domain binding','F','Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization.','2013-10-27','NSRP'),(21053,43399,'tRNA A64-2\'-O-ribosylphosphate transferase activity','F','Catalysis of the transfer of a phosphoribosyl group from 5\'-phosphoribosyl-1\'-pyrophosphate to position 64 of initiator tRNA.','2013-10-27','NSRP'),(21054,43400,'cortisol secretion','P','The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland.','2013-10-27','NSRP'),(21055,43401,'steroid hormone mediated signaling pathway','P','A series of molecular signals mediated by a steroid hormone binding to a receptor.','2013-10-27','NSRP'),(21056,43402,'glucocorticoid mediated signaling pathway','P','A series of molecular signals mediated by the detection of a glucocorticoid hormone.','2013-10-27','NSRP'),(21057,43403,'skeletal muscle tissue regeneration','P','The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage.','2013-10-27','NSRP'),(21058,43404,'corticotropin-releasing hormone receptor activity','F','Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity.','2013-10-27','NSRP'),(21059,43405,'regulation of MAP kinase activity','P','Any process that modulates the frequency, rate or extent of MAP kinase activity.','2013-10-27','NSRP'),(21060,43406,'positive regulation of MAP kinase activity','P','Any process that activates or increases the frequency, rate or extent of MAP kinase activity.','2013-10-27','NSRP'),(21061,43407,'negative regulation of MAP kinase activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.','2013-10-27','NSRP'),(21062,43408,'regulation of MAPK cascade','P','Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade.','2013-10-27','NSRP'),(21063,43409,'negative regulation of MAPK cascade','P','Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade.','2013-10-27','NSRP'),(21064,43410,'positive regulation of MAPK cascade','P','Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.','2013-10-27','NSRP'),(21065,43411,'myopalladin binding','F','OBSOLETE. Interacting selectively and non-covalently with myopalladin, a myofibrillar protein with titin-like Ig domains.','2013-10-27','NSRP'),(21066,43412,'macromolecule modification','P','The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties.','2013-10-27','NSRP'),(21067,43413,'macromolecule glycosylation','P','The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.','2013-10-27','NSRP'),(21068,43414,'macromolecule methylation','P','The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.','2013-10-27','NSRP'),(21069,43415,'positive regulation of skeletal muscle tissue regeneration','P','Any process that activates or increase the rate of skeletal muscle regeneration.','2013-10-27','NSRP'),(21070,43416,'regulation of skeletal muscle tissue regeneration','P','Any process that modulates the frequency, rate or extent of skeletal muscle.','2013-10-27','NSRP'),(21071,43417,'negative regulation of skeletal muscle tissue regeneration','P','Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration.','2013-10-27','NSRP'),(21072,43418,'homocysteine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid.','2013-10-27','NSRP'),(21073,43419,'urea catabolic process','P','The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2.','2013-10-27','NSRP'),(21074,43420,'anthranilate metabolic process','P','The chemical reactions and pathways involving anthranilate (2-aminobenzoate).','2013-10-27','NSRP'),(21075,43421,'anthranilate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate).','2013-10-27','NSRP'),(21076,43422,'protein kinase B binding','F','Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism.','2013-10-27','NSRP'),(21077,43423,'3-phosphoinositide-dependent protein kinase binding','F','Interacting selectively and non-covalently with a 3-phosphoinositide-dependent protein kinase.','2013-10-27','NSRP'),(21078,43424,'protein histidine kinase binding','F','Interacting selectively and non-covalently with protein histidine kinase.','2013-10-27','NSRP'),(21079,43425,'bHLH transcription factor binding','F','Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways.','2013-10-27','NSRP'),(21080,43426,'MRF binding','F','Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors.','2013-10-27','NSRP'),(21081,43427,'carbon fixation by 3-hydroxypropionate cycle','P','An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product.','2013-10-27','NSRP'),(21082,43428,'2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity','F','Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(21083,43429,'2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity','F','Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(21084,43430,'2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity','F','Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(21085,43431,'2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity','F','Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(21086,43433,'negative regulation of sequence-specific DNA binding transcription factor activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.','2013-10-27','NSRP'),(21087,43434,'response to peptide hormone stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.','2013-10-27','NSRP'),(21088,43435,'response to corticotropin-releasing hormone stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response.','2013-10-27','NSRP'),(21089,43436,'oxoacid metabolic process','P','The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).','2013-10-27','NSRP'),(21090,43438,'acetoacetic acid metabolic process','P','The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH.','2013-10-27','NSRP'),(21091,43441,'acetoacetic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH.','2013-10-27','NSRP'),(21092,43442,'acetoacetic acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH.','2013-10-27','NSRP'),(21093,43443,'acetone metabolic process','P','The chemical reactions and pathways involving acetone, propan-2-one.','2013-10-27','NSRP'),(21094,43444,'acetone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of acetone, propan-2-one.','2013-10-27','NSRP'),(21095,43445,'acetone biosynthetic process','P','The chemical reactions and pathways resulting in the formation of acetone, propan-2-one.','2013-10-27','NSRP'),(21096,43446,'cellular alkane metabolic process','P','The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells.','2013-10-27','NSRP'),(21097,43447,'alkane biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2.','2013-10-27','NSRP'),(21098,43448,'alkane catabolic process','P','The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2.','2013-10-27','NSRP'),(21099,43449,'cellular alkene metabolic process','P','The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells.','2013-10-27','NSRP'),(21100,43450,'alkene biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n.','2013-10-27','NSRP'),(21101,43451,'alkene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n.','2013-10-27','NSRP'),(21102,43452,'cellular alkyne metabolic process','P','The chemical reactions and pathways involving an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells.','2013-10-27','NSRP'),(21103,43453,'alkyne biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2.','2013-10-27','NSRP'),(21104,43454,'alkyne catabolic process','P','The chemical reactions and pathways resulting in the breakdown of an alkyne, any cyclic branched or unbranched hydrocarbons having a carbon-carbon triple bond and the general formula CnH2n-2.','2013-10-27','NSRP'),(21105,43455,'regulation of secondary metabolic process','P','Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.','2013-10-27','NSRP'),(21106,43456,'regulation of pentose-phosphate shunt','P','Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis.','2013-10-27','NSRP'),(21107,43457,'regulation of cellular respiration','P','Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds.','2013-10-27','NSRP'),(21108,43458,'ethanol biosynthetic process involved in glucose fermentation to ethanol','P','The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP.','2013-10-27','NSRP'),(21109,43459,'response to short exposure to lithium ion','P','OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus.','2013-10-27','NSRP'),(21110,43460,'response to long exposure to lithium ion','P','OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus.','2013-10-27','NSRP');
INSERT INTO `GO` VALUES (21111,43461,'proton-transporting ATP synthase complex assembly','P','The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes.','2013-10-27','NSRP'),(21112,43462,'regulation of ATPase activity','P','Any process that modulates the rate of ATP hydrolysis by an ATPase.','2013-10-27','NSRP'),(21113,43463,'regulation of rhamnose catabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose.','2013-10-27','NSRP'),(21114,43464,'malolactic fermentation','P','The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP.','2013-10-27','NSRP'),(21115,43465,'regulation of fermentation','P','Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP).','2013-10-27','NSRP'),(21116,43466,'pyrimidine nucleobase fermentation','P','The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP.','2013-10-27','NSRP'),(21117,43467,'regulation of generation of precursor metabolites and energy','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances.','2013-10-27','NSRP'),(21118,43468,'regulation of fucose catabolic process','P','Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose.','2013-10-27','NSRP'),(21119,43469,'regulation of D-xylose catabolic process','P','Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose.','2013-10-27','NSRP'),(21120,43470,'regulation of carbohydrate catabolic process','P','Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates.','2013-10-27','NSRP'),(21121,43471,'regulation of cellular carbohydrate catabolic process','P','Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells.','2013-10-27','NSRP'),(21122,43472,'IgD binding','F','Interacting selectively and non-covalently with an immunoglobulin of a D isotype.','2013-10-27','NSRP'),(21123,43473,'pigmentation','P','The deposition or aggregation of coloring matter in an organism, tissue or cell.','2013-10-27','NSRP'),(21124,43474,'pigment metabolic process involved in pigmentation','P','The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell.','2013-10-27','NSRP'),(21125,43475,'pigment metabolic process involved in pigment accumulation','P','The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, as part of the accumulation of pigment.','2013-10-27','NSRP'),(21126,43476,'pigment accumulation','P','The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus.','2013-10-27','NSRP'),(21127,43477,'pigment biosynthetic process involved in pigment accumulation','P','The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, resulting in pigment accumulation.','2013-10-27','NSRP'),(21128,43478,'pigment accumulation in response to UV light','P','The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus.','2013-10-27','NSRP'),(21129,43479,'pigment accumulation in tissues in response to UV light','P','The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus.','2013-10-27','NSRP'),(21130,43480,'pigment accumulation in tissues','P','The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus.','2013-10-27','NSRP'),(21131,43481,'anthocyanin accumulation in tissues in response to UV light','P','The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus.','2013-10-27','NSRP'),(21132,43482,'cellular pigment accumulation','P','The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus.','2013-10-27','NSRP'),(21133,43483,'anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light','P','The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus.','2013-10-27','NSRP'),(21134,43484,'regulation of RNA splicing','P','Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.','2013-10-27','NSRP'),(21135,43485,'endosome to pigment granule transport','P','The directed movement of substances from endosomes to pigment granules.','2013-10-27','NSRP'),(21136,43486,'histone exchange','P','The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.','2013-10-27','NSRP'),(21137,43487,'regulation of RNA stability','P','Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs.','2013-10-27','NSRP'),(21138,43488,'regulation of mRNA stability','P','Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.','2013-10-27','NSRP'),(21139,43489,'RNA stabilization','P','Prevention of degradation of RNA molecules.','2013-10-27','NSRP'),(21140,43490,'malate-aspartate shuttle','P','The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle.','2013-10-27','NSRP'),(21141,43491,'protein kinase B signaling cascade','P','A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B, which occurs as a result of a single trigger reaction or compound.','2013-10-27','NSRP'),(21142,43492,'ATPase activity, coupled to movement of substances','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance.','2013-10-27','NSRP'),(21143,43493,'viral terminase complex','C','A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides.','2013-10-27','NSRP'),(21144,43494,'CLRC ubiquitin ligase complex','C','An active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation.','2013-10-27','NSRP'),(21145,43495,'protein anchor','F','Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane.','2013-10-27','NSRP'),(21146,43496,'regulation of protein homodimerization activity','P','Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.','2013-10-27','NSRP'),(21147,43497,'regulation of protein heterodimerization activity','P','Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.','2013-10-27','NSRP'),(21148,43498,'cell surface binding','F','OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a cell.','2013-10-27','NSRP'),(21149,43499,'eukaryotic cell surface binding','F','OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a eukaryotic cell.','2013-10-27','NSRP'),(21150,43500,'muscle adaptation','P','A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.','2013-10-27','NSRP'),(21151,43501,'skeletal muscle adaptation','P','Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals.','2013-10-27','NSRP'),(21152,43502,'regulation of muscle adaptation','P','Any process that modulates the frequency, rate or extent of muscle adaptation.','2013-10-27','NSRP'),(21153,43503,'skeletal muscle fiber adaptation','P','Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.','2013-10-27','NSRP'),(21154,43504,'mitochondrial DNA repair','P','The process of restoring mitochondrial DNA after damage.','2013-10-27','NSRP'),(21155,43505,'centromere-specific nucleosome','C','A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3).','2013-10-27','NSRP'),(21156,43506,'regulation of JUN kinase activity','P','Any process that modulates the frequency, rate or extent of JUN kinase activity.','2013-10-27','NSRP'),(21157,43507,'positive regulation of JUN kinase activity','P','Any process that activates or increases the frequency, rate or extent of JUN kinase activity.','2013-10-27','NSRP'),(21158,43508,'negative regulation of JUN kinase activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.','2013-10-27','NSRP'),(21159,43509,'activin A complex','C','A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A).','2013-10-27','NSRP'),(21160,43510,'activin B complex','C','A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B).','2013-10-27','NSRP'),(21161,43511,'inhibin complex','C','Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B.','2013-10-27','NSRP'),(21162,43512,'inhibin A complex','C','Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit.','2013-10-27','NSRP'),(21163,43513,'inhibin B complex','C','Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit.','2013-10-27','NSRP'),(21164,43514,'interleukin-12 complex','C','A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space.','2013-10-27','NSRP'),(21165,43515,'kinetochore binding','F','Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached.','2013-10-27','NSRP'),(21166,43516,'regulation of DNA damage response, signal transduction by p53 class mediator','P','Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.','2013-10-27','NSRP'),(21167,43517,'positive regulation of DNA damage response, signal transduction by p53 class mediator','P','Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.','2013-10-27','NSRP'),(21168,43518,'negative regulation of DNA damage response, signal transduction by p53 class mediator','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.','2013-10-27','NSRP'),(21169,43519,'regulation of myosin II filament organization','P','Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules.','2013-10-27','NSRP'),(21170,43520,'regulation of myosin II filament assembly','P','Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules.','2013-10-27','NSRP'),(21171,43521,'regulation of myosin II filament disassembly','P','Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules.','2013-10-27','NSRP'),(21172,43522,'leucine zipper domain binding','F','Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns.','2013-10-27','NSRP'),(21173,43523,'regulation of neuron apoptotic process','P','Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.','2013-10-27','NSRP'),(21174,43524,'negative regulation of neuron apoptotic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.','2013-10-27','NSRP'),(21175,43525,'positive regulation of neuron apoptotic process','P','Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process.','2013-10-27','NSRP'),(21176,43526,'neuroprotection','P','OBSOLETE. Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss.','2013-10-27','NSRP'),(21177,43527,'tRNA methyltransferase complex','C','A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.','2013-10-27','NSRP'),(21178,43528,'tRNA (m2G10) methyltransferase complex','C','A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p.','2013-10-27','NSRP'),(21179,43529,'GET complex','C','A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins.','2013-10-27','NSRP'),(21180,43530,'adenosine 5\'-monophosphoramidase activity','F','Catalysis of the reaction: adenosine 5\'-monophosphoramidate = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester.','2013-10-27','NSRP'),(21181,43531,'ADP binding','F','Interacting selectively and non-covalently with ADP, adenosine 5\'-diphosphate.','2013-10-27','NSRP'),(21182,43532,'angiostatin binding','F','Interacting selectively and non-covalently with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis.','2013-10-27','NSRP'),(21183,43533,'inositol 1,3,4,5 tetrakisphosphate binding','F','Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate.','2013-10-27','NSRP'),(21184,43534,'blood vessel endothelial cell migration','P','The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis.','2013-10-27','NSRP'),(21185,43535,'regulation of blood vessel endothelial cell migration','P','Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels.','2013-10-27','NSRP'),(21186,43536,'positive regulation of blood vessel endothelial cell migration','P','Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.','2013-10-27','NSRP'),(21187,43537,'negative regulation of blood vessel endothelial cell migration','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels.','2013-10-27','NSRP'),(21188,43538,'regulation of actin phosphorylation','P','Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule.','2013-10-27','NSRP'),(21189,43539,'protein serine/threonine kinase activator activity','F','Increases the activity of a protein serine/threonine kinase.','2013-10-27','NSRP'),(21190,43540,'6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex','C','A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis.','2013-10-27','NSRP'),(21191,43541,'UDP-N-acetylglucosamine transferase complex','C','A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis.','2013-10-27','NSRP'),(21192,43542,'endothelial cell migration','P','The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.','2013-10-27','NSRP'),(21193,43543,'protein acylation','P','The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid.','2013-10-27','NSRP'),(21194,43544,'lipoamide binding','F','Interacting selectively and non-covalently with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group.','2013-10-27','NSRP'),(21195,43545,'molybdopterin cofactor metabolic process','P','The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.','2013-10-27','NSRP'),(21196,43546,'molybdopterin cofactor binding','F','Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.','2013-10-27','NSRP'),(21197,43547,'positive regulation of GTPase activity','P','Any process that activates or increases the activity of a GTPase.','2013-10-27','NSRP'),(21198,43548,'phosphatidylinositol 3-kinase binding','F','Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3\' position of the inositol ring.','2013-10-27','NSRP'),(21199,43549,'regulation of kinase activity','P','Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.','2013-10-27','NSRP'),(21200,43550,'regulation of lipid kinase activity','P','Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.','2013-10-27','NSRP'),(21201,43551,'regulation of phosphatidylinositol 3-kinase activity','P','Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3\' position of the inositol ring.','2013-10-27','NSRP'),(21202,43552,'positive regulation of phosphatidylinositol 3-kinase activity','P','Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.','2013-10-27','NSRP'),(21203,43553,'negative regulation of phosphatidylinositol 3-kinase activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity.','2013-10-27','NSRP'),(21204,43554,'aerobic respiration, using arsenite as electron donor','P','The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems.','2013-10-27','NSRP'),(21205,43555,'regulation of translation in response to stress','P','Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).','2013-10-27','NSRP'),(21206,43556,'regulation of translation in response to oxidative stress','P','Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.','2013-10-27','NSRP'),(21207,43557,'regulation of translation in response to osmotic stress','P','Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.','2013-10-27','NSRP'),(21208,43558,'regulation of translational initiation in response to stress','P','Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress.','2013-10-27','NSRP'),(21209,43559,'insulin binding','F','Interacting selectively and non-covalently with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.','2013-10-27','NSRP'),(21210,43560,'insulin receptor substrate binding','F','Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex.','2013-10-27','NSRP'),(21211,43561,'regulation of translational initiation in response to osmotic stress','P','Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.','2013-10-27','NSRP'),(21212,43562,'cellular response to nitrogen levels','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen.','2013-10-27','NSRP'),(21213,43563,'odorant transporter activity','F','Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(21214,43564,'Ku70:Ku80 complex','C','Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK.','2013-10-27','NSRP'),(21215,43565,'sequence-specific DNA binding','F','Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.','2013-10-27','NSRP'),(21216,43566,'structure-specific DNA binding','F','Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding.','2013-10-27','NSRP'),(21217,43567,'regulation of insulin-like growth factor receptor signaling pathway','P','Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling.','2013-10-27','NSRP'),(21218,43568,'positive regulation of insulin-like growth factor receptor signaling pathway','P','Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.','2013-10-27','NSRP'),(21219,43569,'negative regulation of insulin-like growth factor receptor signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling.','2013-10-27','NSRP'),(21220,43570,'maintenance of DNA repeat elements','P','Any process involved in sustaining the fidelity and copy number of DNA repeat elements.','2013-10-27','NSRP'),(21221,43571,'maintenance of CRISPR repeat elements','P','Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences.','2013-10-27','NSRP'),(21222,43572,'plastid fission','P','The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA.','2013-10-27','NSRP'),(21223,43573,'leucoplast fission','P','The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes.','2013-10-27','NSRP'),(21224,43574,'peroxisomal transport','P','Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.','2013-10-27','NSRP'),(21225,43575,'detection of osmotic stimulus','P','The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal.','2013-10-27','NSRP'),(21226,43576,'regulation of respiratory gaseous exchange','P','Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment.','2013-10-27','NSRP'),(21227,43577,'chemotropism','P','The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it.','2013-10-27','NSRP'),(21228,43578,'nuclear matrix organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane.','2013-10-27','NSRP'),(21229,43579,'elaioplast organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored.','2013-10-27','NSRP'),(21230,43580,'periplasmic space organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi.','2013-10-27','NSRP'),(21231,43581,'mycelium development','P','The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium is the mass of hyphae that constitutes the vegetative part of a fungus.','2013-10-27','NSRP'),(21232,43582,'sporangium development','P','The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores.','2013-10-27','NSRP'),(21233,43583,'ear development','P','The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.','2013-10-27','NSRP'),(21234,43584,'nose development','P','The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).','2013-10-27','NSRP'),(21235,43585,'nose morphogenesis','P','The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity).','2013-10-27','NSRP'),(21236,43586,'tongue development','P','The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.','2013-10-27','NSRP'),(21237,43587,'tongue morphogenesis','P','The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.','2013-10-27','NSRP'),(21238,43588,'skin development','P','The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.','2013-10-27','NSRP'),(21239,43589,'skin morphogenesis','P','The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.','2013-10-27','NSRP'),(21240,43590,'bacterial nucleoid','C','The region of a bacterial cell to which the DNA is confined.','2013-10-27','NSRP'),(21241,43591,'endospore external encapsulating structure','C','The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer.','2013-10-27','NSRP'),(21242,43592,'exosporium','C','The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid.','2013-10-27','NSRP'),(21243,43593,'endospore coat','C','The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination.','2013-10-27','NSRP'),(21244,43594,'outer endospore membrane','C','The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat.','2013-10-27','NSRP'),(21245,43595,'endospore cortex','C','A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan.','2013-10-27','NSRP'),(21246,43596,'nuclear replication fork','C','The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.','2013-10-27','NSRP'),(21247,43597,'cytoplasmic replication fork','C','The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.','2013-10-27','NSRP'),(21248,43598,'cytoplasmic DNA replication factor C complex','C','A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species.','2013-10-27','NSRP'),(21249,43599,'nuclear DNA replication factor C complex','C','A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species.','2013-10-27','NSRP'),(21250,43600,'cytoplasmic replisome','C','A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins.','2013-10-27','NSRP'),(21251,43601,'nuclear replisome','C','A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.','2013-10-27','NSRP'),(21252,43602,'nitrate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid.','2013-10-27','NSRP'),(21253,43603,'cellular amide metabolic process','P','The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells.','2013-10-27','NSRP'),(21254,43604,'amide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.','2013-10-27','NSRP'),(21255,43605,'cellular amide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group.','2013-10-27','NSRP'),(21256,43606,'formamide metabolic process','P','The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid.','2013-10-27','NSRP'),(21257,43607,'formamide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid.','2013-10-27','NSRP'),(21258,43608,'formamide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid.','2013-10-27','NSRP'),(21259,43609,'regulation of carbon utilization','P','Any process that modulates the frequency, rate, or extent of carbon utilization.','2013-10-27','NSRP'),(21260,43610,'regulation of carbohydrate utilization','P','Any process that modulates the frequency, rate or extent of carbohydrate utilization.','2013-10-27','NSRP'),(21261,43611,'isoprene metabolic process','P','The chemical reactions and pathways involving isoprene, C5H8.','2013-10-27','NSRP'),(21262,43612,'isoprene biosynthetic process','P','The chemical reactions and pathways resulting in the formation of isoprene, C5H8.','2013-10-27','NSRP'),(21263,43613,'isoprene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of isoprene, C5H8.','2013-10-27','NSRP'),(21264,43614,'multi-eIF complex','C','A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5.','2013-10-27','NSRP'),(21265,43615,'astrocyte cell migration','P','The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord.','2013-10-27','NSRP'),(21266,43616,'keratinocyte proliferation','P','The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.','2013-10-27','NSRP'),(21267,43617,'cellular response to sucrose starvation','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose.','2013-10-27','NSRP'),(21268,43618,'regulation of transcription from RNA polymerase II promoter in response to stress','P','Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).','2013-10-27','NSRP'),(21269,43619,'regulation of transcription from RNA polymerase II promoter in response to oxidative stress','P','Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.','2013-10-27','NSRP'),(21270,43620,'regulation of DNA-dependent transcription in response to stress','P','Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).','2013-10-27','NSRP'),(21271,43621,'protein self-association','F','Interacting selectively and non-covalently with a domain within the same polypeptide.','2013-10-27','NSRP'),(21272,43622,'cortical microtubule organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell.','2013-10-27','NSRP'),(21273,43623,'cellular protein complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell.','2013-10-27','NSRP'),(21274,43624,'cellular protein complex disassembly','P','The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.','2013-10-27','NSRP'),(21275,43625,'delta DNA polymerase complex','C','A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair.','2013-10-27','NSRP'),(21276,43626,'PCNA complex','C','A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation.','2013-10-27','NSRP'),(21277,43627,'response to estrogen stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.','2013-10-27','NSRP'),(21278,43628,'ncRNA 3\'-end processing','P','Any process involved in forming the mature 3\' end of a non-coding RNA molecule.','2013-10-27','NSRP'),(21279,43629,'ncRNA polyadenylation','P','The enzymatic addition of a sequence of adenylyl residues at the 3\' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3\'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation.','2013-10-27','NSRP'),(21280,43630,'ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process','P','The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3\' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism.','2013-10-27','NSRP'),(21281,43631,'RNA polyadenylation','P','The enzymatic addition of a sequence of adenylyl residues at the 3\' end of an RNA molecule.','2013-10-27','NSRP'),(21282,43632,'modification-dependent macromolecule catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule.','2013-10-27','NSRP'),(21283,43633,'polyadenylation-dependent RNA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3\'-end of the target RNA.','2013-10-27','NSRP'),(21284,43634,'polyadenylation-dependent ncRNA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3\' end the target ncRNA.','2013-10-27','NSRP'),(21285,43635,'methylnaphthalene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar.','2013-10-27','NSRP'),(21286,43636,'bisphenol A catabolic process','P','The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4\'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins.','2013-10-27','NSRP'),(21287,43637,'puromycin metabolic process','P','The chemical reactions and pathways involving puromycin, 3\'-deoxy-N,N-dimethyl-3\'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger.','2013-10-27','NSRP'),(21288,43638,'puromycin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger.','2013-10-27','NSRP'),(21289,43639,'benzoate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid.','2013-10-27','NSRP'),(21290,43640,'benzoate catabolic process via hydroxylation','P','The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol.','2013-10-27','NSRP'),(21291,43641,'novobiocin metabolic process','P','The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase.','2013-10-27','NSRP'),(21292,43642,'novobiocin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase.','2013-10-27','NSRP'),(21293,43643,'tetracycline metabolic process','P','The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).','2013-10-27','NSRP'),(21294,43644,'tetracycline biosynthetic process','P','The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).','2013-10-27','NSRP'),(21295,43645,'cephalosporin metabolic process','P','The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria.','2013-10-27','NSRP'),(21296,43646,'cephalosporin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria.','2013-10-27','NSRP'),(21297,43647,'inositol phosphate metabolic process','P','The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.','2013-10-27','NSRP'),(21298,43648,'dicarboxylic acid metabolic process','P','The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).','2013-10-27','NSRP'),(21299,43649,'dicarboxylic acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.','2013-10-27','NSRP'),(21300,43650,'dicarboxylic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.','2013-10-27','NSRP'),(21301,43651,'linoleic acid metabolic process','P','The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.','2013-10-27','NSRP'),(21302,43652,'engulfment of apoptotic cell','P','The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.','2013-10-27','NSRP'),(21303,43653,'mitochondrial fragmentation involved in apoptotic process','P','The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form.','2013-10-27','NSRP'),(21304,43654,'recognition of apoptotic cell','P','The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis.','2013-10-27','NSRP'),(21305,43655,'extracellular space of host','C','The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream.','2013-10-27','NSRP'),(21306,43656,'intracellular region of host','C','That space within the plasma membrane of a host cell.','2013-10-27','NSRP'),(21307,43657,'host cell','C','A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope.','2013-10-27','NSRP'),(21308,43658,'host symbiosome','C','A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell.','2013-10-27','NSRP'),(21309,43659,'symbiosome','C','A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane).','2013-10-27','NSRP'),(21310,43660,'bacteroid-containing symbiosome','C','A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants.','2013-10-27','NSRP'),(21311,43661,'peribacteroid membrane','C','A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells).','2013-10-27','NSRP'),(21312,43662,'peribacteroid fluid','C','The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome.','2013-10-27','NSRP'),(21313,43663,'host bacteroid-containing symbiosome','C','A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell.','2013-10-27','NSRP'),(21314,43664,'host peribacteroid membrane','C','A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells).','2013-10-27','NSRP'),(21315,43665,'host peribacteroid fluid','C','The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell.','2013-10-27','NSRP'),(21316,43666,'regulation of phosphoprotein phosphatase activity','P','Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein.','2013-10-27','NSRP'),(21317,43667,'pollen wall','C','The complex wall surrounding a pollen grain.','2013-10-27','NSRP'),(21318,43668,'exine','C','The outer layer of the pollen grain wall which is composed primarily of sporopollenin.','2013-10-27','NSRP'),(21319,43669,'ectexine','C','The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections.','2013-10-27','NSRP'),(21320,43670,'foot layer','C','The inner layer of the ectexine.','2013-10-27','NSRP'),(21321,43671,'endexine','C','The inner part of the exine, which stains.','2013-10-27','NSRP'),(21322,43672,'nexine','C','The inner, non-sculptured part of the exine which lies below the sexine.','2013-10-27','NSRP'),(21323,43673,'sexine','C','The outer, sculptured layer of the exine, which lies above the nexine.','2013-10-27','NSRP'),(21324,43674,'columella','C','A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella).','2013-10-27','NSRP'),(21325,43675,'sculpture element','C','The third layer of the sexine.','2013-10-27','NSRP'),(21326,43676,'tectum','C','The layer of sexine which forms a roof over the columella, granules or other infratectal elements.','2013-10-27','NSRP'),(21327,43677,'germination pore','C','A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location.','2013-10-27','NSRP'),(21328,43678,'intine','C','The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm.','2013-10-27','NSRP'),(21329,43679,'axon terminus','C','Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.','2013-10-27','NSRP'),(21330,43680,'filiform apparatus','C','A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells.','2013-10-27','NSRP'),(21331,43682,'copper-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane.','2013-10-27','NSRP'),(21332,43683,'type IV pilus biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a type IV pilus. A type IV pilus is composed of a pilus fiber and approximately ten proteins at its base; type IV pili play a role in cell motility, adherence to substrates, and aggregation.','2013-10-27','NSRP'),(21333,43684,'type IV secretion system complex','C','A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s).','2013-10-27','NSRP'),(21334,43685,'conversion of glutamyl-tRNA to glutaminyl-tRNA','P','The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA.','2013-10-27','NSRP'),(21335,43686,'co-translational protein modification','P','The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome.','2013-10-27','NSRP'),(21336,43687,'post-translational protein modification','P','The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.','2013-10-27','NSRP'),(21337,43688,'conversion of aspartyl-tRNA to asparaginyl-tRNA','P','The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA.','2013-10-27','NSRP'),(21338,43689,'cell-cell adhesion involved in flocculation','P','The attachment of one cell to another cell via adhesion molecules, occurring as a part of the non-sexual aggregation of single-celled organisms.','2013-10-27','NSRP'),(21339,43690,'cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction','P','The attachment of one cell to another cell via protein-carbohydrate (flocculin-mannan) interaction, occurring as a part of the mannose-sensitive, nonsexual aggregation of cells.','2013-10-27','NSRP'),(21340,43691,'reverse cholesterol transport','P','The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism.','2013-10-27','NSRP'),(21341,43692,'monoterpene metabolic process','P','The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure.','2013-10-27','NSRP'),(21342,43693,'monoterpene biosynthetic process','P','The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure.','2013-10-27','NSRP'),(21343,43694,'monoterpene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure.','2013-10-27','NSRP'),(21344,43695,'detection of pheromone','P','The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(21345,43696,'dedifferentiation','P','The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism\'s life history. Under certain conditions, these structures can revert back to the features of their ancestors.','2013-10-27','NSRP'),(21346,43697,'cell dedifferentiation','P','The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism\'s life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors.','2013-10-27','NSRP'),(21347,43698,'iridosome','C','A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance.','2013-10-27','NSRP'),(21348,43699,'leucosome','C','A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast.','2013-10-27','NSRP'),(21349,43700,'pterinosome','C','A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance.','2013-10-27','NSRP'),(21350,43701,'cyanosome','C','A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance.','2013-10-27','NSRP'),(21351,43702,'carotenoid vesicle','C','A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vescicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance.','2013-10-27','NSRP'),(21352,43703,'photoreceptor cell fate determination','P','The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(21353,43704,'photoreceptor cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(21354,43705,'cyanophycin metabolic process','P','The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups.','2013-10-27','NSRP'),(21355,43706,'heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein','P','The attachment of a parasite adhesion molecule to a nonidentical adhesion molecule on the microvasculature of a host cell, thereby adhering the parasite to the host cell.','2013-10-27','NSRP'),(21356,43707,'cell adhesion involved in single-species biofilm formation in or on host organism','P','The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a surface in a host species.','2013-10-27','NSRP'),(21357,43708,'cell adhesion involved in biofilm formation','P','The attachment of a cell to a surface, via cell adhesion molecules, contributing to the formation of a biofilm.','2013-10-27','NSRP'),(21358,43709,'cell adhesion involved in single-species biofilm formation','P','The attachment of a cell to a surface, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.','2013-10-27','NSRP'),(21359,43710,'cell adhesion involved in multi-species biofilm formation','P','The attachment of a cell to a surface, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species.','2013-10-27','NSRP'),(21360,43711,'pilus organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies.','2013-10-27','NSRP'),(21361,43712,'2-hydroxyisocaproate CoA-transferase activity','F','Catalysis of the reaction: 2-oxoisocaproate + CoA = (R)-2-hydroxyisocaproyl-CoA.','2013-10-27','NSRP'),(21362,43713,'(R)-2-hydroxyisocaproate dehydrogenase activity','F','Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+.','2013-10-27','NSRP'),(21363,43714,'(R)-citramalate synthase activity','F','Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA.','2013-10-27','NSRP'),(21364,43715,'2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity','F','Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P.','2013-10-27','NSRP'),(21365,43716,'2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity','F','Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene.','2013-10-27','NSRP'),(21366,43717,'2-hydroxyglutaryl-CoA dehydratase activity','F','Catalysis of the reaction: (R)-2-hydroxyglutaryl-CoA = H2O + glutaconyl-CoA.','2013-10-27','NSRP'),(21367,43718,'2-hydroxymethylglutarate dehydrogenase activity','F','Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH.','2013-10-27','NSRP'),(21368,43719,'2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity','F','Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O.','2013-10-27','NSRP'),(21369,43720,'3-keto-5-aminohexanoate cleavage activity','F','Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate.','2013-10-27','NSRP'),(21370,43721,'4-hydroxybutanoyl-CoA dehydratase activity','F','Catalysis of the reaction: 4-hydroxybutanoyl-CoA = vinylacetyl-CoA + H2O.','2013-10-27','NSRP'),(21371,43722,'4-hydroxyphenylacetate decarboxylase activity','F','Catalysis of the reaction: (4-hydroxyphenyl)acetate + H(+) = 4-cresol + CO(2).','2013-10-27','NSRP'),(21372,43723,'2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5\'-phosphate deaminase activity','F','Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia.','2013-10-27','NSRP'),(21373,43724,'2-keto-3-deoxygalactonate aldolase activity','F','Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate.','2013-10-27','NSRP'),(21374,43725,'2-keto-3-deoxygluconate aldolase activity','F','Catalysis of the reaction: 2-keto-3-deoxygluconate = D-glyceraldehyde + pyruvate.','2013-10-27','NSRP'),(21375,43726,'5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity','F','Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate.','2013-10-27','NSRP'),(21376,43727,'5-amino-4-imidazole carboxylate lyase activity','F','Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate.','2013-10-27','NSRP'),(21377,43728,'2-keto-4-methylthiobutyrate aminotransferase activity','F','Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine.','2013-10-27','NSRP'),(21378,43729,'2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity','F','Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate.','2013-10-27','NSRP'),(21379,43730,'5-ureido-4-imidazole carboxylate hydrolase activity','F','Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2.','2013-10-27','NSRP'),(21380,43731,'6-hydroxynicotinate 3-monooxygenase activity','F','Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD.','2013-10-27','NSRP'),(21381,43732,'6-hydroxynicotinate dehydrogenase activity','F','Catalysis of the reaction: 6-hydroxynicotinate + H(2)O + O(2) = 2,6-dihydroxynicotinate + H(2)O(2).','2013-10-27','NSRP'),(21382,43733,'DNA-3-methylbase glycosylase activity','F','Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1\' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site.','2013-10-27','NSRP'),(21383,43734,'DNA-N1-methyladenine dioxygenase activity','F','Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde.','2013-10-27','NSRP'),(21384,43736,'DNA-3-methyladenine glycosylase IV activity','F','OBSOLETE. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1\' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.','2013-10-27','NSRP'),(21385,43737,'deoxyribonuclease V activity','F','Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5\'-phosphate.','2013-10-27','NSRP'),(21386,43738,'reduced coenzyme F420 dehydrogenase activity','F','Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420.','2013-10-27','NSRP'),(21387,43739,'G/U mismatch-specific uracil-DNA glycosylase activity','F','Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1\' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site.','2013-10-27','NSRP'),(21388,43740,'GTP cyclohydrolase IIa activity','F','Catalysis of the reaction: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5\'-phosphate + 3 H(+) + 2 phosphate.','2013-10-27','NSRP'),(21389,43741,'L-2-aminoadipate N-acetyltransferase activity','F','Catalysis of the reaction: L-2-aminoadipate + acetyl-CoA = N2-acetyl-L-aminoadipate + CoA.','2013-10-27','NSRP'),(21390,43743,'LPPG:FO 2-phospho-L-lactate transferase activity','F','Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5\'-guanosine = coenzyme F420-0 + GMP.','2013-10-27','NSRP'),(21391,43744,'N2-acetyl-L-aminoadipate kinase activity','F','Catalysis of the reaction: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate.','2013-10-27','NSRP'),(21392,43745,'N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity','F','Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate.','2013-10-27','NSRP'),(21393,43746,'N2-acetyl-L-lysine aminotransferase activity','F','Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine.','2013-10-27','NSRP'),(21394,43747,'N2-acetyl-L-lysine deacetylase activity','F','Catalysis of the reaction: N2-acetyl-L-lysine + H2O = acetate + L-lysine.','2013-10-27','NSRP'),(21395,43748,'O-succinylbenzoate synthase activity','F','Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate.','2013-10-27','NSRP'),(21396,43749,'phenol, water dikinase activity','F','Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate.','2013-10-27','NSRP'),(21397,43750,'phosphatidylinositol alpha-mannosyltransferase activity','F','Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol.','2013-10-27','NSRP'),(21398,43751,'polyphosphate:AMP phosphotransferase activity','F','Catalysis of the reaction: (polyphosphate)n + AMP = (polyphosphate)n-1 + ADP.','2013-10-27','NSRP'),(21399,43752,'adenosylcobinamide kinase activity','F','Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP).','2013-10-27','NSRP'),(21400,43754,'dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity','F','Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine.','2013-10-27','NSRP'),(21401,43755,'alpha-ribazole phosphatase activity','F','Catalysis of the reaction: alpha-ribazole 5\'-phosphate + H(2)O = alpha-ribazole + phosphate.','2013-10-27','NSRP'),(21402,43756,'adenosylcobinamide hydrolase activity','F','Catalysis of the reaction: adenosylcobinamide + H(2)O = (R)-1-aminopropan-2-ol + adenosylcobyrate.','2013-10-27','NSRP'),(21403,43757,'adenosylcobinamide-phosphate synthase activity','F','Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide.','2013-10-27','NSRP'),(21404,43758,'acetate-CoA ligase (ADP-forming) activity','F','Catalysis of the reaction: ATP + acetate + CoA = ADP + phosphate + acetyl-CoA.','2013-10-27','NSRP'),(21405,43759,'branched-chain acyl-CoA synthetase (ADP-forming) activity','F','Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = ADP + orthophosphate + 2-methylbutanoyl-CoA.','2013-10-27','NSRP'),(21406,43760,'acetyldiaminopimelate aminotransferase activity','F','Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate.','2013-10-27','NSRP'),(21407,43761,'archaetidylserine synthase activity','F','Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP.','2013-10-27','NSRP'),(21408,43762,'aryl-CoA synthetase (ADP-forming) activity','F','Catalysis of the reaction: ATP + phenylacetate + CoA = ADP + orthophosphate + phenylacetyl-CoA.','2013-10-27','NSRP'),(21409,43763,'UTP:glucose-1-phosphate uridylyltransferase regulator activity','F','Modulates the activity of UTP:glucose-1-phosphate uridylyltransferase.','2013-10-27','NSRP'),(21410,43764,'UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity','F','Catalysis of the reaction: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier protein].','2013-10-27','NSRP'),(21411,43765,'T/G mismatch-specific endonuclease activity','F','Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine.','2013-10-27','NSRP'),(21412,43766,'Sep-tRNA:Cys-tRNA synthase activity','F','Catalysis of the reaction: O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate.','2013-10-27','NSRP'),(21413,43767,'pyrrolysyl-tRNA synthetase activity','F','Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl).','2013-10-27','NSRP'),(21414,43768,'S-ribosylhomocysteine lyase activity','F','Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine.','2013-10-27','NSRP'),(21415,43769,'Tpg-containing telomere binding complex','C','A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species.','2013-10-27','NSRP'),(21416,43770,'demethylmenaquinone methyltransferase activity','F','Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(21417,43771,'cytidine kinase activity','F','Catalysis of the reaction: ATP + cytidine = ADP + CMP.','2013-10-27','NSRP'),(21418,43772,'acyl-phosphate glycerol-3-phosphate acyltransferase activity','F','Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate.','2013-10-27','NSRP'),(21419,43773,'coenzyme F420-0 gamma-glutamyl ligase activity','F','Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates.','2013-10-27','NSRP'),(21420,43774,'coenzyme F420-2 alpha-glutamyl ligase activity','F','Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate.','2013-10-27','NSRP'),(21421,43775,'cobyrinate a,c-diamide synthase activity','F','Catalysis of the reaction: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 orthophosphate.','2013-10-27','NSRP'),(21422,43776,'cobalt-precorrin-6B C5-methyltransferase activity','F','Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7.','2013-10-27','NSRP'),(21423,43777,'cobalt-precorrin-7 C15-methyltransferase activity','F','Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2.','2013-10-27','NSRP'),(21424,43778,'cobalt-precorrin-8 methylmutase activity','F','Catalysis of the reaction: cobalt-precorrin 8 = cobyrinate.','2013-10-27','NSRP'),(21425,43779,'cobalt-precorrin-5A acetaldehyde-lyase activity','F','Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde.','2013-10-27','NSRP'),(21426,43780,'cobalt-precorrin-5B C1-methyltransferase activity','F','Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A.','2013-10-27','NSRP'),(21427,43781,'cobalt-factor II C20-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III.','2013-10-27','NSRP'),(21428,43782,'cobalt-precorrin-3 C17-methyltransferase activity','F','Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(21429,43783,'oxidoreductase activity, oxidizing metal ions with flavin as acceptor','F','Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor.','2013-10-27','NSRP'),(21430,43784,'cob(II)yrinic acid a,c-diamide reductase activity','F','Catalysis of the reaction: 2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH(2).','2013-10-27','NSRP'),(21431,43785,'cinnamoyl-CoA:phenyllactate CoA-transferase activity','F','Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate.','2013-10-27','NSRP'),(21432,43786,'cinnamate reductase activity','F','Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+.','2013-10-27','NSRP'),(21433,43788,'cardiolipin synthetase 2 activity','F','Catalysis of the reaction: 2 1,2-diacyl-sn-glycero-3-[phospho-rac-(1-glycerol)] = cardiolipin + glycerol.','2012-03-14','NSRP'),(21434,43791,'dimethylamine methyltransferase activity','F','Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine.','2013-10-27','NSRP'),(21435,43792,'enamidase activity','F','Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H(2)O = 2-formylglutarate + NH(4)(+).','2013-10-27','NSRP'),(21436,43793,'beta-ribofuranosylaminobenzene 5\'-phosphate synthase activity','F','Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5\'-phosphate + CO2 + diphosphate.','2013-10-27','NSRP'),(21437,43794,'formate dehydrogenase (coenzyme F420) activity','F','Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420.','2013-10-27','NSRP'),(21438,43795,'glyceraldehyde oxidoreductase activity','F','Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor.','2013-10-27','NSRP'),(21439,43796,'glyceraldehyde dehydrogenase (NADP) activity','F','Catalysis of the reaction: D-glyceraldehyde + H2O + NADP+ = D-glycerate + NADPH + H+.','2013-10-27','NSRP'),(21440,43797,'glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity','F','Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin.','2013-10-27','NSRP'),(21441,43798,'glycerate 2-kinase activity','F','Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP.','2013-10-27','NSRP'),(21442,43799,'glycine oxidase activity','F','Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide.','2013-10-27','NSRP'),(21443,43800,'hexulose-6-phosphate isomerase activity','F','Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate.','2013-10-27','NSRP'),(21444,43801,'hexulose-6-phosphate synthase activity','F','Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate.','2013-10-27','NSRP'),(21445,43802,'hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity','F','Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H(2)O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H(+) + hydrogenobyrinate a,c-diamide + 2 phosphate.','2013-10-27','NSRP'),(21446,43803,'hydroxyneurosporene-O-methyltransferase activity','F','Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = spheroidene + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(21447,43804,'imidazolone hydrolase activity','F','Catalysis of the reaction: N-formiminoglycine = imidazolone + H2O.','2013-10-27','NSRP'),(21448,43805,'indolepyruvate ferredoxin oxidoreductase activity','F','Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin.','2013-10-27','NSRP'),(21449,43806,'keto acid formate lyase activity','F','Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate.','2013-10-27','NSRP'),(21450,43807,'3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity','F','Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin.','2013-10-27','NSRP'),(21451,43808,'lyso-ornithine lipid acyltransferase activity','F','Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein].','2013-10-27','NSRP'),(21452,43810,'ornithine-acyl [acyl carrier protein] N-acyltransferase activity','F','Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein].','2013-10-27','NSRP'),(21453,43811,'phosphate:acyl-[acyl carrier protein] acyltransferase activity','F','Catalysis of the reaction: acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein].','2013-10-27','NSRP'),(21454,43812,'phosphatidylinositol-4-phosphate phosphatase activity','F','Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate.','2013-10-27','NSRP'),(21455,43813,'phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity','F','Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate.','2013-10-27','NSRP'),(21456,43814,'phospholactate guanylyltransferase activity','F','Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5\'-guanosine + diphosphate.','2013-10-27','NSRP'),(21457,43815,'phosphoribosylglycinamide formyltransferase 2 activity','F','Catalysis of the reaction: formate + ATP + 5\'-phospho-ribosylglycinamide = 5\'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate.','2013-10-27','NSRP'),(21458,43816,'phosphoserine-tRNA(Cys) ligase activity','F','Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys).','2013-10-27','NSRP'),(21459,43817,'phosphosulfolactate synthase activity','F','Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite.','2013-10-27','NSRP'),(21460,43818,'precorrin-3B synthase activity','F','Catalysis of the reaction: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B.','2013-10-27','NSRP'),(21461,43819,'precorrin-6A synthase (deacetylating) activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H(+) + precorrin-6X.','2013-10-27','NSRP'),(21462,43820,'propionyl-CoA dehydrogenase activity','F','Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA.','2013-10-27','NSRP'),(21463,43821,'propionyl-CoA:succinate CoA-transferase activity','F','Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate.','2013-10-27','NSRP'),(21464,43822,'ribonuclease M5 activity','F','Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5\'- and 3\'-termini of a 5S-rRNA precursor.','2013-10-27','NSRP'),(21465,43823,'spheroidene monooxygenase activity','F','Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O.','2013-10-27','NSRP'),(21466,43824,'succinylglutamate-semialdehyde dehydrogenase activity','F','Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H(2)O + NAD(+) = N-succinyl-L-glutamate + 2 H(+) + NADH.','2013-10-27','NSRP'),(21467,43825,'succinylornithine transaminase activity','F','Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate.','2013-10-27','NSRP'),(21468,43826,'sulfur oxygenase reductase activity','F','Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+.','2013-10-27','NSRP'),(21469,43827,'tRNA (adenine-57, 58-N(1)-) methyltransferase activity','F','Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA.','2013-10-27','NSRP'),(21470,43828,'tRNA 2-selenouridine synthase activity','F','Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA).','2013-10-27','NSRP'),(21471,43829,'tRNA-specific adenosine-37 deaminase activity','F','Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule.','2013-10-27','NSRP'),(21472,43830,'thiol-driven fumarate reductase activity','F','Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide.','2013-10-27','NSRP'),(21473,43831,'thiosulfate dehydrogenase (quinone) activity','F','Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate.','2013-10-27','NSRP'),(21474,43833,'methylamine-specific methylcobalamin:coenzyme M methyltransferase activity','F','Catalysis of the reaction: a methylated methylamine corrinoid protein + coenzyme M = a methylamine corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M.','2013-10-27','NSRP'),(21475,43834,'trimethylamine methyltransferase activity','F','Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine.','2013-10-27','NSRP'),(21476,43835,'uracil/thymine dehydrogenase activity','F','OBSOLETE. Catalysis of the reactions: uracil + H2O + acceptor = barbiturate + reduced acceptor; and thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor.','2013-10-27','NSRP'),(21477,43836,'xanthine hydrolase activity','F','Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate.','2013-10-27','NSRP'),(21478,43837,'valine dehydrogenase (NAD) activity','F','Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH.','2013-10-27','NSRP'),(21479,43838,'phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity','F','Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol.','2013-10-27','NSRP'),(21480,43839,'lipid A phosphate methyltransferase activity','F','Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A.','2013-10-27','NSRP'),(21481,43840,'branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity','F','Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine.','2013-10-27','NSRP'),(21482,43841,'(S)-lactate 2-kinase activity','F','Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP.','2013-10-27','NSRP'),(21483,43842,'Kdo transferase activity','F','Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP.','2013-10-27','NSRP'),(21484,43843,'ADP-specific glucokinase activity','F','Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate.','2013-10-27','NSRP'),(21485,43844,'ADP-specific phosphofructokinase activity','F','Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate.','2013-10-27','NSRP'),(21486,43845,'DNA polymerase III, proofreading complex','C','A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit\'s proofreading activity.','2013-10-27','NSRP'),(21487,43846,'DNA polymerase III, clamp loader complex','C','A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands.','2013-10-27','NSRP'),(21488,43847,'DNA polymerase III, clamp loader chi/psi subcomplex','C','A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB).','2013-10-27','NSRP'),(21489,43848,'excinuclease cho activity','F','Catalysis of the incision of damaged DNA on the 3\' side of a lesion, typically at the ninth phosphodiester bond 3\' of the damage.','2013-10-27','NSRP'),(21490,43849,'Ras palmitoyltransferase activity','F','Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins.','2013-10-27','NSRP'),(21491,43850,'RecFOR complex','C','A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair.','2013-10-27','NSRP'),(21492,43851,'methanol-specific methylcobalamin:coenzyme M methyltransferase activity','F','Catalysis of the reaction: a methylated methanol corrinoid protein + coenzyme M = a methanol corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M.','2013-10-27','NSRP'),(21493,43852,'monomethylamine methyltransferase activity','F','Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3.','2013-10-27','NSRP'),(21494,43853,'methanol-CoM methyltransferase complex','C','A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol.','2013-10-27','NSRP'),(21495,43854,'cyclic nucleotide-gated mechanosensitive ion channel activity','F','Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(21496,43855,'cyclic nucleotide-gated ion channel activity','F','Catalysis of the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(21497,43856,'anti-sigma factor antagonist activity','F','The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity.','2013-10-27','NSRP'),(21498,43857,'N-acetylornithine carbamoyltransferase activity','F','Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H(+) + phosphate.','2013-10-27','NSRP'),(21499,43858,'arginine:ornithine antiporter activity','F','Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out).','2013-10-27','NSRP'),(21500,43859,'cyanophycinase activity','F','OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides.','2013-10-27','NSRP'),(21501,43860,'cyanophycin synthetase activity','F','Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer).','2013-10-27','NSRP'),(21502,43861,'agmatine:putrescine antiporter activity','F','Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out).','2013-10-27','NSRP'),(21503,43862,'arginine:agmatine antiporter activity','F','Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out).','2013-10-27','NSRP'),(21504,43863,'4-hydroxy-2-ketopimelate aldolase activity','F','Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate.','2013-10-27','NSRP'),(21505,43864,'indoleacetamide hydrolase activity','F','Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA.','2013-10-27','NSRP'),(21506,43865,'methionine transmembrane transporter activity','F','Catalysis of the transfer of methionine from one side of a membrane to the other.','2013-10-27','NSRP'),(21507,43866,'adenylyl-sulfate reductase (thioredoxin) activity','F','Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5\'-adenylyl sulfate + thioredoxin.','2013-10-27','NSRP'),(21508,43867,'7-cyano-7-deazaguanine tRNA-ribosyltransferase activity','F','Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine.','2013-10-27','NSRP'),(21509,43868,'N-acetylaminoadipate kinase activity','F','Catalysis of the reaction: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate.','2012-03-14','NSRP'),(21510,43869,'alpha-aminoadipate acetyltransferase activity','F','Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A.','2013-10-27','NSRP'),(21511,43870,'N-acetyl-gamma-aminoadipyl-phosphate reductase activity','F','Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH.','2013-10-27','NSRP'),(21512,43871,'delta1-piperideine-6-carboxylate dehydrogenase activity','F','Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate.','2013-10-27','NSRP'),(21513,43872,'lysine:cadaverine antiporter activity','F','Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out).','2013-10-27','NSRP'),(21514,43873,'pyruvate-flavodoxin oxidoreductase activity','F','Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin.','2013-10-27','NSRP'),(21515,43874,'acireductone synthase activity','F','Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate.','2013-10-27','NSRP'),(21516,43875,'2-ketobutyrate formate-lyase activity','F','Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate.','2013-10-27','NSRP'),(21517,43876,'D-threonine aldolase activity','F','Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde.','2013-10-27','NSRP'),(21518,43877,'galactosamine-6-phosphate isomerase activity','F','Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3.','2013-10-27','NSRP'),(21519,43878,'glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity','F','Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+.','2013-10-27','NSRP'),(21520,43879,'glycolate transmembrane transporter activity','F','Catalysis of the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA).','2013-10-27','NSRP'),(21521,43880,'crotonyl-CoA reductase activity','F','Catalysis of the reduction of crotonyl-CoA to butyryl-CoA.','2013-10-27','NSRP'),(21522,43881,'mesaconyl-CoA hydratase activity','F','Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA.','2013-10-27','NSRP'),(21523,43882,'malate:sodium symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in).','2013-10-27','NSRP'),(21524,43883,'malolactic enzyme activity','F','Catalysis of the reaction: malate + H+ = L-lactate + CO2.','2013-10-27','NSRP'),(21525,43884,'CO-methylating acetyl-CoA synthase activity','F','Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA.','2013-10-27','NSRP'),(21526,43885,'carbon-monoxide dehydrogenase (ferredoxin) activity','F','Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin.','2013-10-27','NSRP'),(21527,43886,'structural constituent of carboxysome','F','The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide.','2013-10-27','NSRP'),(21528,43887,'melibiose:sodium symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in).','2013-10-27','NSRP'),(21529,43888,'(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity','F','Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate.','2013-10-27','NSRP'),(21530,43889,'(S)-3-O-geranylgeranylglyceryl phosphate synthase activity','F','Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate.','2013-10-27','NSRP'),(21531,43890,'N-acetylgalactosamine-6-sulfatase activity','F','Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.','2013-10-27','NSRP'),(21532,43891,'glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity','F','Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+.','2013-10-27','NSRP'),(21533,43892,'methylglyoxal reductase (NADPH-dependent) activity','F','Catalysis of the reaction: lactaldehyde + NADP+ = methylglyoxal + NADPH + H+.','2013-10-27','NSRP'),(21534,43893,'acetate:cation symporter activity','F','Catalysis of the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in).','2013-10-27','NSRP'),(21535,43894,'acetyl-CoA synthetase acetyltransferase activity','F','Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate.','2013-10-27','NSRP'),(21536,43895,'cyclomaltodextrin glucanotransferase activity','F','Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond.','2013-10-27','NSRP'),(21537,43896,'glucan 1,6-alpha-glucosidase activity','F','Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides.','2013-10-27','NSRP'),(21538,43897,'glucan 1,4-alpha-maltohydrolase activity','F','Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains.','2013-10-27','NSRP'),(21539,43898,'2,3-dihydroxybiphenyl 1,2-dioxygenase activity','F','Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid.','2013-10-27','NSRP'),(21540,43899,'phosphoserine:homoserine phosphotransferase activity','F','Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine.','2013-10-27','NSRP'),(21541,43900,'regulation of multi-organism process','P','Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.','2013-10-27','NSRP'),(21542,43901,'negative regulation of multi-organism process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.','2013-10-27','NSRP'),(21543,43902,'positive regulation of multi-organism process','P','Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species.','2013-10-27','NSRP'),(21544,43903,'regulation of symbiosis, encompassing mutualism through parasitism','P','Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association.','2013-10-27','NSRP'),(21545,43904,'isochorismate pyruvate lyase activity','F','Catalysis of the reaction: isochorismate = salicylate + pyruvate.','2013-10-27','NSRP'),(21546,43905,'Ser-tRNA(Thr) hydrolase activity','F','Catalysis of the hydrolysis of misacylated Ser-tRNA(Thr).','2013-10-27','NSRP'),(21547,43906,'Ala-tRNA(Pro) hydrolase activity','F','Catalysis of the hydrolysis of misacylated Ala-tRNA(Pro).','2013-10-27','NSRP'),(21548,43907,'Cys-tRNA(Pro) hydrolase activity','F','Catalysis of the hydrolysis of misacylated Cys-tRNA(Pro).','2013-10-27','NSRP'),(21549,43908,'Ser(Gly)-tRNA(Ala) hydrolase activity','F','Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala).','2013-10-27','NSRP'),(21550,43909,'N-acetylcitrulline deacetylase activity','F','Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate.','2013-10-27','NSRP'),(21551,43910,'ATP:coenzyme F420 adenylyltransferase activity','F','Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate.','2013-10-27','NSRP'),(21552,43911,'D-lysine transaminase activity','F','Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate.','2013-10-27','NSRP'),(21553,43912,'D-lysine oxidase activity','F','Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide.','2013-10-27','NSRP'),(21554,43913,'chromosome segregation-directing complex','C','A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology.','2013-10-27','NSRP'),(21555,43914,'NADPH:sulfur oxidoreductase activity','F','Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+.','2013-10-27','NSRP'),(21556,43915,'L-seryl-tRNA(Sec) kinase activity','F','Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec).','2013-10-27','NSRP'),(21557,43916,'DNA-7-methylguanine glycosylase activity','F','Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1\' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site.','2013-10-27','NSRP'),(21558,43917,'ribose 1,5-bisphosphate isomerase activity','F','Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate.','2013-10-27','NSRP'),(21559,43918,'cadaverine aminopropyltransferase activity','F','Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5\'-methylthioadenosine + N-(3-aminopropyl)cadaverine.','2013-10-27','NSRP'),(21560,43919,'agmatine aminopropyltransferase activity','F','Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5\'-methylthioadenosine.','2013-10-27','NSRP'),(21561,43920,'aminopropylagmatine ureohydrolase activity','F','Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea.','2013-10-27','NSRP'),(21562,43921,'modulation by host of viral transcription','P','Any process in which a host organism modulates the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.','2013-10-27','NSRP'),(21563,43922,'negative regulation by host of viral transcription','P','Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.','2013-10-27','NSRP'),(21564,43923,'positive regulation by host of viral transcription','P','Any process is which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.','2013-10-27','NSRP'),(21565,43924,'suramin binding','F','Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms.','2013-10-27','NSRP'),(21566,43927,'exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay','P','The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5\'-cap.','2013-10-27','NSRP'),(21567,43928,'exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay','P','The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3\'-poly(A) tail.','2013-10-27','NSRP'),(21568,43929,'primary ovarian follicle growth involved in double layer follicle stage','P','Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), as part of the double layer follicle stage of oogenesis.','2013-10-27','NSRP'),(21569,43930,'primary ovarian follicle growth involved in primary follicle stage','P','Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) as part of the primary follicle stage of oogenesis.','2013-10-27','NSRP'),(21570,43931,'ossification involved in bone maturation','P','The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state.','2013-10-27','NSRP'),(21571,43932,'ossification involved in bone remodeling','P','The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli.','2013-10-27','NSRP'),(21572,43933,'macromolecular complex subunit organization','P','Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex.','2013-10-27','NSRP'),(21573,43934,'sporulation','P','The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.','2013-10-27','NSRP'),(21574,43935,'sexual sporulation resulting in formation of a cellular spore','P','The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.','2013-10-27','NSRP'),(21575,43936,'asexual sporulation resulting in formation of a cellular spore','P','The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.','2013-10-27','NSRP'),(21576,43937,'regulation of sporulation','P','Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure.','2013-10-27','NSRP'),(21577,43938,'positive regulation of sporulation','P','Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure.','2013-10-27','NSRP'),(21578,43939,'negative regulation of sporulation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure.','2013-10-27','NSRP'),(21579,43940,'regulation of sexual sporulation resulting in formation of a cellular spore','P','Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis.','2013-10-27','NSRP'),(21580,43941,'positive regulation of sexual sporulation resulting in formation of a cellular spore','P','Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis.','2013-10-27','NSRP'),(21581,43942,'negative regulation of sexual sporulation resulting in formation of a cellular spore','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis.','2013-10-27','NSRP'),(21582,43943,'regulation of asexual sporulation resulting in formation of a cellular spore','P','Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis.','2013-10-27','NSRP'),(21583,43944,'negative regulation of asexual sporulation resulting in formation of a cellular spore','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis.','2013-10-27','NSRP'),(21584,43945,'positive regulation of asexual sporulation resulting in formation of a cellular spore','P','Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis.','2013-10-27','NSRP'),(21585,43946,'positive regulation of catalytic activity in other organism involved in symbiotic interaction','P','Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction.','2013-10-27','NSRP'),(21586,43947,'positive regulation by host of symbiont catalytic activity','P','Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21587,43948,'positive regulation by symbiont of host catalytic activity','P','Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21588,43949,'regulation of cAMP-mediated signaling','P','Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.','2013-10-27','NSRP'),(21589,43950,'positive regulation of cAMP-mediated signaling','P','Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.','2013-10-27','NSRP'),(21590,43951,'negative regulation of cAMP-mediated signaling','P','Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response.','2013-10-27','NSRP'),(21591,43952,'protein transport by the Sec complex','P','The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.','2013-10-27','NSRP'),(21592,43953,'protein transport by the Tat complex','P','The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex.','2013-10-27','NSRP'),(21593,43954,'cellular component maintenance','P','The organization process that preserves a cellular component in a stable functional or structural state.','2013-10-27','NSRP'),(21594,43955,'3-hydroxypropionyl-CoA synthetase activity','F','Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate.','2013-10-27','NSRP'),(21595,43956,'3-hydroxypropionyl-CoA dehydratase activity','F','Catalysis of the reaction: 3-hydroxypropionyl-CoA = acrylyl-CoA + H2O.','2013-10-27','NSRP'),(21596,43957,'acryloyl-CoA reductase (NADP+) activity','F','Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+.','2013-10-27','NSRP'),(21597,43958,'acryloyl-CoA reductase activity','F','Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein.','2013-10-27','NSRP'),(21598,43959,'L-erythro-3-methylmalyl-CoA lyase activity','F','Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA.','2013-10-27','NSRP'),(21599,43960,'L-erythro-3-methylmalyl-CoA dehydratase activity','F','Catalysis of the reaction: L-erythro-3-methylmalyl-CoA = mesaconyl-CoA + H2O.','2013-10-27','NSRP'),(21600,43961,'succinyl-CoA:(R)-citramalate CoA-transferase activity','F','Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA.','2013-10-27','NSRP'),(21601,43962,'negative regulation by host of symbiont adenylate cyclase-mediated signal transduction','P','Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21602,43963,'modulation by symbiont of host adenylate cyclase-mediated signal transduction','P','Any process in which the symbiont modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21603,43964,'positive regulation by symbiont of host adenylate cyclase-mediated signal transduction','P','Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21604,43965,'negative regulation by symbiont of host adenylate cyclase-mediated signal transduction','P','Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21605,43966,'histone H3 acetylation','P','The modification of histone H3 by the addition of an acetyl group.','2013-10-27','NSRP'),(21606,43967,'histone H4 acetylation','P','The modification of histone H4 by the addition of an acetyl group.','2013-10-27','NSRP'),(21607,43968,'histone H2A acetylation','P','The modification of histone H2A by the addition of an acetyl group.','2013-10-27','NSRP'),(21608,43969,'histone H2B acetylation','P','The modification of histone H2B by the addition of an acetyl group.','2013-10-27','NSRP'),(21609,43970,'histone H3-K9 acetylation','P','The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone.','2013-10-27','NSRP'),(21610,43971,'histone H3-K18 acetylation','P','The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone.','2013-10-27','NSRP'),(21611,43972,'histone H3-K23 acetylation','P','The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone.','2013-10-27','NSRP'),(21612,43973,'histone H3-K4 acetylation','P','The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone.','2013-10-27','NSRP'),(21613,43974,'histone H3-K27 acetylation','P','The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone.','2013-10-27','NSRP'),(21614,43975,'histone H3-K36 acetylation','P','The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone.','2013-10-27','NSRP'),(21615,43976,'histone H3-K79 acetylation','P','The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone.','2013-10-27','NSRP'),(21616,43977,'histone H2A-K5 acetylation','P','The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone.','2013-10-27','NSRP'),(21617,43978,'histone H2A-K9 acetylation','P','The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone.','2013-10-27','NSRP'),(21618,43979,'histone H2B-K5 acetylation','P','The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone.','2013-10-27','NSRP'),(21619,43980,'histone H2B-K12 acetylation','P','The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone.','2013-10-27','NSRP'),(21620,43981,'histone H4-K5 acetylation','P','The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone.','2013-10-27','NSRP'),(21621,43982,'histone H4-K8 acetylation','P','The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone.','2013-10-27','NSRP'),(21622,43983,'histone H4-K12 acetylation','P','The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone.','2013-10-27','NSRP'),(21623,43984,'histone H4-K16 acetylation','P','The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.','2013-10-27','NSRP'),(21624,43985,'histone H4-R3 methylation','P','The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone.','2013-10-27','NSRP'),(21625,43987,'histone H3-S10 phosphorylation','P','The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.','2013-10-27','NSRP'),(21626,43988,'histone H3-S28 phosphorylation','P','The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.','2013-10-27','NSRP'),(21627,43989,'histone H4-S1 phosphorylation','P','The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone.','2013-10-27','NSRP'),(21628,43990,'histone H2A-S1 phosphorylation','P','The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone.','2013-10-27','NSRP'),(21629,43991,'histone H2B-S14 phosphorylation','P','The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone.','2013-10-27','NSRP'),(21630,43992,'histone acetyltransferase activity (H3-K9 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9).','2013-10-27','NSRP'),(21631,43993,'histone acetyltransferase activity (H3-K18 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18).','2013-10-27','NSRP'),(21632,43994,'histone acetyltransferase activity (H3-K23 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23).','2013-10-27','NSRP'),(21633,43995,'histone acetyltransferase activity (H4-K5 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5).','2013-10-27','NSRP'),(21634,43996,'histone acetyltransferase activity (H4-K8 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8).','2013-10-27','NSRP'),(21635,43997,'histone acetyltransferase activity (H4-K12 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12).','2013-10-27','NSRP'),(21636,43998,'H2A histone acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine.','2013-10-27','NSRP'),(21637,43999,'histone acetyltransferase activity (H2A-K5 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5).','2013-10-27','NSRP'),(21638,44000,'movement in host','P','The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21639,44001,'migration in host','P','The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21640,44002,'acquisition of nutrients from host','P','The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21641,44003,'modification by symbiont of host morphology or physiology','P','The process in which a symbiont organism effects a change in the structure or processes of its host organism.','2013-10-27','NSRP'),(21642,44004,'disruption by symbiont of host cell','P','Any process in which an organism has a negative effect on the functioning of the host\'s cells. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21643,44005,'induction by symbiont in host of tumor, nodule, or growth','P','The process in which an organism causes the formation of a mass of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21644,44006,'induction by symbiont in host of tumor, nodule, or growth containing transformed cells','P','The process in which an organism causes the formation in its host organism of a growth whose cells have been transformed and continue to exist in the absence of the first organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21645,44007,'dissemination or transmission of symbiont from host','P','The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21646,44008,'dissemination or transmission of symbiont from host by vector','P','The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21647,44009,'viral transmission by vector','P','The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection.','2013-10-27','NSRP'),(21648,44010,'single-species biofilm formation','P','A process in which microorganisms of the same species attach to and grow on a surface such, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.','2013-10-27','NSRP'),(21649,44011,'single-species biofilm formation on inanimate substrate','P','A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.','2013-10-27','NSRP'),(21650,44012,'histone acetyltransferase activity (H2A-K9 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9).','2013-10-27','NSRP'),(21651,44013,'H2B histone acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine.','2013-10-27','NSRP'),(21652,44014,'histone acetyltransferase activity (H2B-K5 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5).','2013-10-27','NSRP'),(21653,44015,'histone acetyltransferase activity (H2B-K12 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12).','2013-10-27','NSRP'),(21654,44016,'histone acetyltransferase activity (H3-K4 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4).','2013-10-27','NSRP'),(21655,44017,'histone acetyltransferase activity (H3-K27 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27).','2013-10-27','NSRP'),(21656,44018,'histone acetyltransferase activity (H3-K36 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36).','2013-10-27','NSRP'),(21657,44019,'histone acetyltransferase activity (H3-K72 specific)','F','Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72).','2013-10-27','NSRP'),(21658,44020,'histone methyltransferase activity (H4-R3 specific)','F','Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4.','2013-10-27','NSRP'),(21659,44022,'histone kinase activity (H3-S28 specific)','F','Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3.','2013-10-27','NSRP'),(21660,44023,'histone kinase activity (H4-S1 specific)','F','Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H4.','2013-10-27','NSRP'),(21661,44024,'histone kinase activity (H2A-S1 specific)','F','Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A.','2013-10-27','NSRP'),(21662,44025,'histone kinase activity (H2B-S14 specific)','F','Catalysis of the transfer of a phosphate group to the serine-14 residue of the N-terminal tail of histone H2B.','2013-10-27','NSRP'),(21663,44026,'DNA hypermethylation','P','An increase in the epigenetic methylation of cytosine and adenosine residues in DNA.','2013-10-27','NSRP'),(21664,44027,'hypermethylation of CpG island','P','An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.','2013-10-27','NSRP'),(21665,44028,'DNA hypomethylation','P','An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA.','2013-10-27','NSRP'),(21666,44029,'hypomethylation of CpG island','P','An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes.','2013-10-27','NSRP'),(21667,44030,'regulation of DNA methylation','P','Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.','2013-10-27','NSRP'),(21668,44031,'modification by symbiont of host protein by phosphorylation','P','The process in which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21669,44032,'modulation by symbiont of indole acetic acid levels in host','P','The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21670,44033,'multi-organism metabolic process','P','A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism.','2013-10-27','NSRP'),(21671,44034,'multi-organism biosynthetic process','P','A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - which involves more than one organism.','2013-10-27','NSRP'),(21672,44035,'multi-organism catabolic process','P','A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves more than one organism.','2013-10-27','NSRP'),(21673,44036,'cell wall macromolecule metabolic process','P','The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.','2013-10-27','NSRP'),(21674,44037,'multi-organism cell wall macromolecule metabolic process','P','The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall, involving more than one organism. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.','2013-10-27','NSRP'),(21675,44038,'cell wall macromolecule biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall.','2013-10-27','NSRP'),(21676,44039,'cellular cell wall macromolecule catabolic process','P','The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall, occurring at the level of the cell.','2012-03-14','NSRP'),(21677,44040,'multi-organism carbohydrate metabolic process','P','The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, that involve more than one organism.','2013-10-27','NSRP'),(21678,44041,'multi-organism carbohydrate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, involving more than one organism.','2013-10-27','NSRP'),(21679,44042,'glucan metabolic process','P','The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues.','2013-10-27','NSRP'),(21680,44043,'multi-organism glucan metabolic process','P','The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, involving more than one organism.','2013-10-27','NSRP'),(21681,44044,'interaction with host via substance in symbiont surface','P','An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21682,44045,'interaction with host via substance in symbiont cell outer membrane','P','An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21683,44046,'interaction with host via substance released outside of symbiont','P','An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis.','2013-10-27','NSRP'),(21684,44047,'interaction with host via protein secreted by type I secretion system','P','An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type I secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21685,44048,'interaction with host via protein secreted by type V secretion system','P','An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type V secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21686,44049,'interaction with host via protein secreted by type VI secretion system','P','An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type VI secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21687,44050,'interaction with host via substance released by sporangium lysis','P','An interaction with the host organism mediated by a substance released via rupture of symbiont sporangia, structures producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21688,44051,'interaction with host via substance released by symbiont cytolysis','P','An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21689,44052,'interaction with host via substance released by membrane budding','P','An interaction with the host organism mediated by a substance released via symbiont membrane budding, the evagination of a membrane resulting in formation of a vesicle.','2013-10-27','NSRP'),(21690,44053,'translocation of peptides or proteins into host cell cytoplasm','P','The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm.','2013-10-27','NSRP'),(21691,44054,'rounding by symbiont of host cells','P','Any process in which an organism causes host cells to change shape and become round.','2013-10-27','NSRP'),(21692,44055,'modulation by symbiont of host system process','P','The alteration by a symbiont organism of the functioning of a system process in the host. A system process is a multicellular organismal process carried out by any of the organs or tissues in an organ system.','2013-10-27','NSRP'),(21693,44056,'modulation by symbiont of host digestive system process','P','The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.','2013-10-27','NSRP'),(21694,44057,'regulation of system process','P','Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system.','2013-10-27','NSRP'),(21695,44058,'regulation of digestive system process','P','Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.','2013-10-27','NSRP'),(21696,44059,'modulation by symbiont of host endocrine process','P','The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism.','2013-10-27','NSRP'),(21697,44060,'regulation of endocrine process','P','Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system.','2013-10-27','NSRP'),(21698,44061,'modulation by symbiont of host excretion','P','The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity.','2013-10-27','NSRP'),(21699,44062,'regulation of excretion','P','Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity.','2013-10-27','NSRP'),(21700,44063,'modulation by symbiont of host neurological system process','P','The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.','2013-10-27','NSRP'),(21701,44064,'modulation by symbiont of host respiratory system process','P','The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.','2013-10-27','NSRP'),(21702,44065,'regulation of respiratory system process','P','Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system.','2013-10-27','NSRP'),(21703,44066,'modification by symbiont of host cell nucleus','P','The process in which a symbiont organism effects a change in the structure or function of its host cell nucleus.','2013-10-27','NSRP'),(21704,44067,'modification by symbiont of host intercellular junctions','P','The process in which a symbiont organism effects a change in the structure or function of its host intercellular junction, a specialized region of connection between two cells.','2013-10-27','NSRP'),(21705,44068,'modulation by symbiont of host cellular process','P','Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism.','2013-10-27','NSRP'),(21706,44069,'modification by symbiont of host anion transport','P','The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism.','2013-10-27','NSRP'),(21707,44070,'regulation of anion transport','P','Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(21708,44071,'modulation by symbiont of host cell cycle','P','The process in which a symbiont organism effects a change in its host\'s cell cycle through direct interactions with the host cell macromolecular machinery.','2013-10-27','NSRP'),(21709,44072,'negative regulation by symbiont of host cell cycle','P','The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host\'s progression through its cell cycle via direct interactions with the host cell macromolecular machinery.','2013-10-27','NSRP'),(21710,44073,'modulation by symbiont of host translation','P','The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism.','2013-10-27','NSRP'),(21711,44074,'negative regulation by symbiont of host translation','P','The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism.','2013-10-27','NSRP'),(21712,44075,'modulation by symbiont of host vacuole organization','P','Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism.','2013-10-27','NSRP'),(21713,44076,'positive regulation by symbiont of host vacuole organization','P','The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism.','2013-10-27','NSRP'),(21714,44077,'modulation by symbiont of host receptor-mediated endocytosis','P','The process in which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism.','2013-10-27','NSRP'),(21715,44078,'positive regulation by symbiont of host receptor-mediated endocytosis','P','Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism.','2013-10-27','NSRP'),(21716,44079,'modulation by symbiont of host neurotransmitter secretion','P','Any process in which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell in its host organism.','2013-10-27','NSRP'),(21717,44080,'modulation by symbiont of host cGMP-mediated signal transduction','P','Any process in which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.','2013-10-27','NSRP'),(21718,44081,'modulation by symbiont of host nitric oxide-mediated signal transduction','P','Any process in which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).','2013-10-27','NSRP'),(21719,44082,'modulation by symbiont of host small GTPase mediated signal transduction','P','Any process in which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism.','2013-10-27','NSRP'),(21720,44083,'modulation by symbiont of host Rho protein signal transduction','P','Any process in which a symbiont organism modulates the frequency, rate or extent of Rho protein signal transduction in its host organism.','2013-10-27','NSRP'),(21721,44084,'host cell membrane pore complex','C','Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins.','2013-10-27','NSRP'),(21722,44085,'cellular component biogenesis','P','A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component.','2013-10-27','NSRP'),(21723,44087,'regulation of cellular component biogenesis','P','Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.','2013-10-27','NSRP'),(21724,44088,'regulation of vacuole organization','P','Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.','2013-10-27','NSRP'),(21725,44089,'positive regulation of cellular component biogenesis','P','Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component.','2013-10-27','NSRP'),(21726,44090,'positive regulation of vacuole organization','P','Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole.','2013-10-27','NSRP'),(21727,44091,'membrane biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane.','2013-10-27','NSRP'),(21728,44092,'negative regulation of molecular function','P','Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.','2013-10-27','NSRP'),(21729,44093,'positive regulation of molecular function','P','Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.','2013-10-27','NSRP'),(21730,44094,'host cell nuclear part','C','Any constituent part of a host cell\'s nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21731,44095,'host cell nucleoplasm','C','That part of a host cell\'s nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21732,44096,'type IV pilus','C','A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers.','2013-10-27','NSRP'),(21733,44097,'secretion by the type IV secretion system','P','The controlled release of proteins or DNA by a cell, via the type IV secretion system.','2013-10-27','NSRP'),(21734,44098,'DNA secretion by the type IV secretion system','P','The controlled release of DNA by a cell, via the type IV secretion system.','2013-10-27','NSRP'),(21735,44099,'polar tube','C','A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell.','2013-10-27','NSRP'),(21736,44100,'sporoplasm','C','The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms.','2013-10-27','NSRP'),(21737,44101,'(R)-citramalyl-CoA lyase activity','F','Catalysis of the reaction: (R)-citramalyl-CoA = pyruvate + acetyl-CoA.','2013-10-27','NSRP'),(21738,44102,'purine deoxyribosyltransferase activity','F','Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor.','2013-10-27','NSRP'),(21739,44103,'L-arabinose 1-dehydrogenase (NADP+) activity','F','Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+.','2013-10-27','NSRP'),(21740,44104,'2,5-dioxovalerate dehydrogenase (NAD+) activity','F','Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+.','2013-10-27','NSRP'),(21741,44105,'L-xylulose reductase (NAD+) activity','F','Catalysis of the reaction: xylitol + NAD+ = L-xylulose + NADH + H+.','2013-10-27','NSRP'),(21742,44106,'cellular amine metabolic process','P','The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.','2013-10-27','NSRP'),(21743,44107,'cellular alcohol metabolic process','P','The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells.','2013-10-27','NSRP'),(21744,44108,'cellular alcohol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell.','2013-10-27','NSRP'),(21745,44109,'cellular alcohol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell.','2013-10-27','NSRP'),(21746,44110,'growth involved in symbiotic interaction','P','The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction.','2013-10-27','NSRP'),(21747,44111,'development involved in symbiotic interaction','P','The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction.','2013-10-27','NSRP'),(21748,44112,'growth in other organism involved in symbiotic interaction','P','The increase in size or mass of an organism, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism.','2013-10-27','NSRP'),(21749,44113,'development in other organism involved in symbiotic interaction','P','The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism.','2013-10-27','NSRP'),(21750,44114,'development of symbiont in host','P','The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21751,44115,'development of symbiont involved in interaction with host','P','The progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21752,44116,'growth of symbiont involved in interaction with host','P','The increase in size or mass of an organism, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21753,44117,'growth of symbiont in host','P','The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21754,44118,'development of symbiont in host cell','P','The progression of the symbiont from an initial condition to a later condition, occurring in its host\'s cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21755,44119,'growth of symbiont in host cell','P','The increase in size or mass of symbiont, occurring in its host\'s cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21756,44120,'development of symbiont in host organelle','P','The progression of the symbiont from an initial condition to a later condition, occurring in its host\'s organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21757,44121,'growth of symbiont in host organelle','P','The increase in size or mass of a symbiont, occurring in its host\'s organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21758,44122,'development of symbiont in host vascular tissue','P','The progression of the symbiont from an initial condition to a later condition, occurring in its host\'s vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21759,44123,'growth of symbiont in host vascular tissue','P','The increase in size or mass of symbiont, occurring in its host\'s vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21760,44124,'development of symbiont in host intercellular space','P','The progression of the symbiont from an initial condition to a later condition, occurring in its host\'s intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21761,44125,'growth of symbiont in host intercellular space','P','The increase in size or mass of symbiont, occurring in its host\'s intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21762,44126,'regulation of growth of symbiont in host','P','Any process in which the symbiont regulates the increase in its size or mass within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction.','2013-10-27','NSRP'),(21763,44127,'regulation of development of symbiont in host','P','Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction.','2013-10-27','NSRP'),(21764,44128,'positive regulation of growth of symbiont in host','P','Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction.','2013-10-27','NSRP'),(21765,44129,'positive regulation of development of symbiont in host','P','Any process in which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction.','2013-10-27','NSRP'),(21766,44130,'negative regulation of growth of symbiont in host','P','Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction.','2013-10-27','NSRP'),(21767,44131,'negative regulation of development of symbiont in host','P','Any process in which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction.','2013-10-27','NSRP'),(21768,44132,'development of symbiont on or near host','P','The progression of a symbiont from an initial condition to a later condition, within the cells or tissues of its host organism.','2013-10-27','NSRP'),(21769,44133,'growth of symbiont on or near host','P','The increase in size or mass of a symbiont within the cells or tissues of its host organism.','2013-10-27','NSRP'),(21770,44134,'development of symbiont on or near host phyllosphere','P','The progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21771,44135,'growth of symbiont on or near host phyllosphere','P','The increase in size or mass of symbiont occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21772,44136,'development of symbiont on or near host rhizosphere','P','The progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21773,44137,'growth of symbiont on or near host rhizosphere','P','The increase in size or mass of symbiont occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21774,44138,'modulation of development of symbiont on or near host','P','Any process in which the symbiont regulates its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism.','2013-10-27','NSRP'),(21775,44139,'modulation of growth of symbiont on or near host','P','Any process in which the symbiont regulates the increase in its size or mass on or near the cells or tissues of the host organism.','2013-10-27','NSRP'),(21776,44140,'negative regulation of growth of symbiont on or near host surface','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont\'s size or mass on or near the cells or tissues of the host organism.','2013-10-27','NSRP'),(21777,44141,'negative regulation of development of symbiont on or near host surface','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the symbiont\'s progression from an initial condition to a later condition, on or near the cells or tissues of the host organism.','2013-10-27','NSRP'),(21778,44142,'positive regulation of growth of symbiont on or near host surface','P','Any process that activates or increases the frequency, rate or extent of the symbiont\'s increase in size or mass on or near the cells or tissues of the host organism.','2013-10-27','NSRP'),(21779,44143,'positive regulation of development of symbiont on or near host surface','P','Any process that activates or increases the frequency, rate or extent of the symbiont\'s progression from an initial condition to a later condition, on or near the cells or tissues of the host organism.','2013-10-27','NSRP'),(21780,44144,'modulation of growth of symbiont involved in interaction with host','P','Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism.','2013-10-27','NSRP'),(21781,44145,'modulation of development of symbiont involved in interaction with host','P','Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism.','2013-10-27','NSRP'),(21782,44146,'negative regulation of growth of symbiont involved in interaction with host','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism.','2013-10-27','NSRP'),(21783,44147,'negative regulation of development of symbiont involved in interaction with host','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism.','2013-10-27','NSRP'),(21784,44148,'positive regulation of growth of symbiont involved in interaction with host','P','Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism.','2013-10-27','NSRP'),(21785,44149,'positive regulation of development of symbiont involved in interaction with host','P','Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism.','2013-10-27','NSRP'),(21786,44150,'development of organism on or near symbiont surface','P','The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21787,44151,'growth of organism on or near symbiont surface','P','The increase in size or mass of an organism occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21788,44152,'development on or near surface of other organism involved in symbiotic interaction','P','The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction.','2013-10-27','NSRP'),(21789,44153,'growth on or near surface of other organism involved in symbiotic interaction','P','The increase in size or mass of an organism occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction.','2013-10-27','NSRP'),(21790,44154,'histone H3-K14 acetylation','P','The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone.','2013-10-27','NSRP'),(21791,44155,'host caveola','C','A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21792,44156,'host cell junction','C','A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.','2013-10-27','NSRP'),(21793,44157,'host cell projection','C','A prolongation or process extending from a host cell, e.g. a flagellum or axon.','2013-10-27','NSRP'),(21794,44158,'host cell wall','C','The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan.','2013-10-27','NSRP'),(21795,44159,'host thylakoid','C','A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.','2013-10-27','NSRP'),(21796,44160,'host thylakoid membrane','C','The pigmented membrane of any host thylakoid.','2013-10-27','NSRP'),(21797,44161,'host cell cytoplasmic vesicle','C','A vesicle formed of membrane or protein, found in the cytoplasm of a host cell.','2013-10-27','NSRP'),(21798,44162,'host cell cytoplasmic vesicle membrane','C','The lipid bilayer surrounding a host cell cytoplasmic vesicle.','2013-10-27','NSRP'),(21799,44163,'host cytoskeleton','C','Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.','2013-10-27','NSRP'),(21800,44164,'host cell cytosol','C','The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.','2013-10-27','NSRP'),(21801,44165,'host cell endoplasmic reticulum','C','The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).','2013-10-27','NSRP'),(21802,44166,'host cell endoplasmic reticulum lumen','C','The volume enclosed by the membranes of the host cell endoplasmic reticulum.','2013-10-27','NSRP'),(21803,44167,'host cell endoplasmic reticulum membrane','C','The lipid bilayer surrounding the host cell endoplasmic reticulum.','2013-10-27','NSRP'),(21804,44168,'host cell rough endoplasmic reticulum','C','The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface.','2013-10-27','NSRP'),(21805,44169,'host cell rough endoplasmic reticulum membrane','C','The lipid bilayer surrounding the host cell rough endoplasmic reticulum.','2013-10-27','NSRP'),(21806,44170,'host cell smooth endoplasmic reticulum','C','The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface.','2013-10-27','NSRP'),(21807,44171,'host cell smooth endoplasmic reticulum membrane','C','The lipid bilayer surrounding the host cell smooth endoplasmic reticulum.','2013-10-27','NSRP'),(21808,44172,'host cell endoplasmic reticulum-Golgi intermediate compartment','C','A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport.','2013-10-27','NSRP'),(21809,44173,'host cell endoplasmic reticulum-Golgi intermediate compartment membrane','C','The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system.','2013-10-27','NSRP'),(21810,44174,'host cell endosome','C','A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation.','2013-10-27','NSRP'),(21811,44175,'host cell endosome membrane','C','The lipid bilayer surrounding a host cell endosome.','2013-10-27','NSRP'),(21812,44176,'host cell filopodium','C','Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward.','2013-10-27','NSRP'),(21813,44177,'host cell Golgi apparatus','C','A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.','2013-10-27','NSRP'),(21814,44178,'host cell Golgi membrane','C','The lipid bilayer surrounding any of the compartments of the host cell Golgi apparatus.','2013-10-27','NSRP'),(21815,44179,'hemolysis in other organism','P','The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another.','2013-10-27','NSRP'),(21816,44180,'filamentous growth of a unicellular organism','P','The process in which a unicellular organism grows in a threadlike, filamentous shape.','2013-10-27','NSRP'),(21817,44181,'filamentous growth of a multicellular organism','P','The process in which a multicellular organism grows in a threadlike, filamentous shape.','2013-10-27','NSRP'),(21818,44182,'filamentous growth of a population of unicellular organisms','P','The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.','2013-10-27','NSRP'),(21819,44183,'protein binding involved in protein folding','F','Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding.','2013-10-27','NSRP'),(21820,44184,'host cell late endosome','C','A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.','2013-10-27','NSRP'),(21821,44185,'host cell late endosome membrane','C','The lipid bilayer surrounding a host cell late endosome.','2013-10-27','NSRP'),(21822,44186,'host cell lipid particle','C','Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins.','2013-10-27','NSRP'),(21823,44187,'host cell lysosome','C','A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions.','2013-10-27','NSRP'),(21824,44188,'host cell lysosomal membrane','C','The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm.','2013-10-27','NSRP'),(21825,44189,'host cell microsome','C','OBSOLETE: Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g.','2013-10-27','NSRP'),(21826,44190,'host cell mitochondrial envelope','C','The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space.','2013-10-27','NSRP'),(21827,44191,'host cell mitochondrial membrane','C','Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope.','2013-10-27','NSRP'),(21828,44192,'host cell mitochondrial inner membrane','C','The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae.','2013-10-27','NSRP'),(21829,44193,'host cell mitochondrial outer membrane','C','The outer, i.e. cytoplasm-facing, lipid bilayer of the host cell mitochondrial envelope.','2013-10-27','NSRP'),(21830,44194,'cytolytic granule','C','A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells.','2013-10-27','NSRP'),(21831,44195,'nucleoplasmic reticulum','C','Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport.','2013-10-27','NSRP'),(21832,44196,'host cell nucleolus','C','A small, dense body one or more of which are present in the nucleus of eukaryotic host cells.','2013-10-27','NSRP'),(21833,44197,'Rel homology domain binding','F','Interacting selectively and non-covalently with a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT.','2013-10-27','NSRP'),(21834,44198,'zf-TRAF domain binding','F','Interacting selectively and non-covalently with a TRAF-type zinc finger domain of a protein.','2013-10-27','NSRP'),(21835,44199,'host cell nuclear envelope','C','The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).','2013-10-27','NSRP'),(21836,44200,'host cell nuclear membrane','C','Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space.','2013-10-27','NSRP'),(21837,44201,'host cell nuclear inner membrane','C','The inner, i.e. lumen-facing, lipid bilayer of the host nuclear envelope.','2013-10-27','NSRP'),(21838,44202,'host cell nuclear outer membrane','C','The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes.','2013-10-27','NSRP'),(21839,44203,'host cell nuclear lamina','C','The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments.','2013-10-27','NSRP'),(21840,44204,'host cell nuclear matrix','C','The dense fibrillar network lying on the inner side of the host nuclear membrane.','2013-10-27','NSRP'),(21841,44205,'\'de novo\' UMP biosynthetic process','P','The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.','2013-10-27','NSRP'),(21842,44206,'UMP salvage','P','Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis.','2013-10-27','NSRP'),(21843,44207,'translation initiation ternary complex','C','A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).','2013-10-27','NSRP'),(21844,44208,'\'de novo\' AMP biosynthetic process','P','The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5\'-monophosphate (IMP).','2013-10-27','NSRP'),(21845,44209,'AMP salvage','P','The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3\',5\'-bisphosphate) without de novo synthesis.','2013-10-27','NSRP'),(21846,44210,'\'de novo\' CTP biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cytidine 5\'-triphosphate (CTP) from simpler components.','2013-10-27','NSRP'),(21847,44211,'CTP salvage','P','Any process which produces cytidine 5\'-triphosphate (CTP) from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(21848,44212,'transcription regulatory region DNA binding','F','Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.','2013-10-27','NSRP'),(21849,44213,'intronic transcription regulatory region DNA binding','F','Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within.','2013-10-27','NSRP'),(21850,44214,'fully spanning plasma membrane','C','Fully spanning both phospholipid bilayers of a plasma membrane.','2013-10-27','NSRP'),(21851,44215,'other organism','C','A secondary organism with which the first organism is interacting.','2013-10-27','NSRP'),(21852,44216,'other organism cell','C','A cell of a secondary organism with which the first organism is interacting.','2013-10-27','NSRP'),(21853,44217,'other organism part','C','Any constituent part of a secondary organism with which the first organism is interacting.','2013-10-27','NSRP'),(21854,44218,'other organism cell membrane','C','The cell membrane of a secondary organism with which the first organism is interacting.','2013-10-27','NSRP'),(21855,44219,'host cell plasmodesma','C','A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell.','2013-10-27','NSRP'),(21856,44220,'host cell perinuclear region of cytoplasm','C','The host cell cytoplasm situated near, or occurring around, the host nucleus.','2013-10-27','NSRP'),(21857,44221,'host cell synapse','C','The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication.','2013-10-27','NSRP'),(21858,44222,'anammoxosome','C','An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism.','2013-10-27','NSRP'),(21859,44223,'pirellulosome','C','A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm.','2013-10-27','NSRP'),(21860,44224,'juxtaparanode region of axon','C','A region of an axon near a node of Ranvier that is between the paranode and internode regions.','2013-10-27','NSRP'),(21861,44225,'apical pole of neuron','C','Portion of a neuron cell soma closest to the point where the apical dendrite emerges.','2013-10-27','NSRP'),(21862,44226,'basal pole of neuron','C','Portion of a neuron cell soma closest to the point where the basilar dendrite emerges.','2013-10-27','NSRP'),(21863,44227,'methane-oxidizing organelle','C','A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms.','2013-10-27','NSRP'),(21864,44228,'host cell surface','C','The external part of the host cell wall and/or host plasma membrane.','2013-10-27','NSRP'),(21865,44229,'host cell periplasmic space','C','The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi).','2013-10-27','NSRP'),(21866,44230,'host cell envelope','C','An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present.','2013-10-27','NSRP'),(21867,44231,'host cell presynaptic membrane','C','A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.','2013-10-27','NSRP'),(21868,44232,'organelle membrane contact site','C','A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions.','2013-10-27','NSRP'),(21869,44233,'ER-mitochondrion membrane contact site','C','A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange.','2013-10-27','NSRP'),(21870,44234,'cell wall organization in other organism','P','A process performed by an organism that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall of a second organism.','2012-03-14','NSRP'),(21871,44235,'cellular component organization in other organism','P','A process which results in the assembly, arrangement of constituent parts, or disassembly of a cellular component in a second organism.','2012-03-14','NSRP'),(21872,44236,'multicellular organismal metabolic process','P','The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required.','2013-10-27','NSRP'),(21873,44237,'cellular metabolic process','P','The chemical reactions and pathways by which individual cells transform chemical substances.','2013-10-27','NSRP'),(21874,44238,'primary metabolic process','P','The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.','2013-10-27','NSRP'),(21875,44239,'salivary polysaccharide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth.','2013-10-27','NSRP'),(21876,44240,'multicellular organismal lipid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of lipids, occurring at the tissue, organ, or organismal level of a multicellular organism.','2013-10-27','NSRP'),(21877,44241,'lipid digestion','P','The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism.','2013-10-27','NSRP'),(21878,44242,'cellular lipid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells.','2013-10-27','NSRP'),(21879,44243,'multicellular organismal catabolic process','P','The chemical reactions and pathways resulting in the breakdown of substances in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required.','2013-10-27','NSRP'),(21880,44244,'multicellular organismal polysaccharide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of polysaccharides, occurring at the tissue, organ, or organismal level of a multicellular organism.','2013-10-27','NSRP'),(21881,44245,'polysaccharide digestion','P','The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism.','2013-10-27','NSRP'),(21882,44246,'regulation of multicellular organismal metabolic process','P','Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21883,44247,'cellular polysaccharide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells.','2013-10-27','NSRP'),(21884,44248,'cellular catabolic process','P','The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.','2013-10-27','NSRP'),(21885,44249,'cellular biosynthetic process','P','The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.','2013-10-27','NSRP'),(21886,44250,'negative regulation of metabolic activity involved in hibernation','P','The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation.','2013-10-27','NSRP'),(21887,44251,'protein catabolic process by pepsin','P','The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid).','2013-10-27','NSRP'),(21888,44252,'negative regulation of multicellular organismal metabolic process','P','Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21889,44253,'positive regulation of multicellular organismal metabolic process','P','Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21890,44254,'multicellular organismal protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a protein in a multicellular organism, occurring at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21891,44255,'cellular lipid metabolic process','P','The chemical reactions and pathways involving lipids, as carried out by individual cells.','2013-10-27','NSRP'),(21892,44256,'protein digestion','P','The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism.','2013-10-27','NSRP'),(21893,44257,'cellular protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a protein by individual cells.','2013-10-27','NSRP'),(21894,44258,'intestinal lipid catabolic process','P','The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas.','2013-10-27','NSRP'),(21895,44259,'multicellular organismal macromolecule metabolic process','P','The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21896,44260,'cellular macromolecule metabolic process','P','The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells.','2013-10-27','NSRP'),(21897,44261,'multicellular organismal carbohydrate metabolic process','P','The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in a single multicellular organism, occurring at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21898,44262,'cellular carbohydrate metabolic process','P','The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.','2013-10-27','NSRP'),(21899,44263,'multicellular organismal polysaccharide metabolic process','P','The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, in multicellular organisms that occur at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21900,44264,'cellular polysaccharide metabolic process','P','The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells.','2013-10-27','NSRP'),(21901,44265,'cellular macromolecule catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells.','2013-10-27','NSRP'),(21902,44266,'multicellular organismal macromolecule catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21903,44267,'cellular protein metabolic process','P','The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.','2013-10-27','NSRP'),(21904,44268,'multicellular organismal protein metabolic process','P','The chemical reactions and pathways involving a specific protein, rather than of proteins in general, in multicellular organisms occurring at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21905,44269,'glycerol ether catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol.','2013-10-27','NSRP'),(21906,44270,'cellular nitrogen compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds.','2013-10-27','NSRP'),(21907,44271,'cellular nitrogen compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds.','2013-10-27','NSRP'),(21908,44272,'sulfur compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.','2013-10-27','NSRP'),(21909,44273,'sulfur compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.','2013-10-27','NSRP'),(21910,44274,'multicellular organismal biosynthetic process','P','The chemical reactions and pathways resulting in the formation of substances in multicellular organisms, occurring at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21911,44275,'cellular carbohydrate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells.','2013-10-27','NSRP'),(21912,44276,'multicellular organismal carbohydrate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in a single multicellular organism occurring at the tissue, organ, or organismal level.','2013-10-27','NSRP'),(21913,44277,'cell wall disassembly','P','A process that results in the breakdown of the cell wall.','2013-10-27','NSRP'),(21914,44278,'cell wall disruption in other organism','P','A process carried out by an organism that results in the breakdown of the cell wall of a second organism.','2013-10-27','NSRP'),(21915,44279,'other organism membrane','C','A membrane of a secondary organism with which the first organism is interacting.','2013-10-27','NSRP'),(21916,44280,'subplasmalemmal coating','C','Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier.','2013-10-27','NSRP'),(21917,44281,'small molecule metabolic process','P','The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.','2013-10-27','NSRP'),(21918,44282,'small molecule catabolic process','P','The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.','2013-10-27','NSRP'),(21919,44283,'small molecule biosynthetic process','P','The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.','2013-10-27','NSRP'),(21920,44284,'mitochondrial crista junction','C','A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane.','2013-10-27','NSRP'),(21921,44285,'bridge contact site','C','Site of contact between the inner and outer mitochondrial membrane found in neuronal mitochondria; may play a role in maintaining the structural integrity of the inner and outer boundary membranes.','2013-10-27','NSRP'),(21922,44286,'peg and socket contact','C','A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells.','2013-10-27','NSRP'),(21923,44288,'puncta adhaerentia','C','A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells.','2013-10-27','NSRP'),(21924,44289,'contact site','C','Sites of close apposition of the inner and outer mitochondrial membrane.','2013-10-27','NSRP'),(21925,44290,'mitochondrial intracristal space','C','The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space.','2013-10-27','NSRP'),(21926,44291,'cell-cell contact zone','C','Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.','2013-10-27','NSRP'),(21927,44292,'dendrite terminus','C','A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole.','2013-10-27','NSRP'),(21928,44293,'dendriole','C','Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC).','2013-10-27','NSRP'),(21929,44294,'dendritic growth cone','C','The migrating motile tip of a growing nerve cell dendrite.','2013-10-27','NSRP'),(21930,44295,'axonal growth cone','C','The migrating motile tip of a growing nerve cell axon.','2013-10-27','NSRP'),(21931,44296,'dendritic tuft','C','The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance.','2013-10-27','NSRP'),(21932,44297,'cell body','C','The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.','2013-10-27','NSRP'),(21933,44298,'cell body membrane','C','The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections.','2013-10-27','NSRP'),(21934,44299,'C-fiber','C','The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated.','2013-10-27','NSRP'),(21935,44300,'cerebellar mossy fiber','C','An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \"mossy\" appearance in Golgi stained preparations.','2013-10-27','NSRP'),(21936,44301,'climbing fiber','C','The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to \"climb\" along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber.','2013-10-27','NSRP'),(21937,44302,'dentate gyrus mossy fiber','C','Distinctive, unmyelinated axons produced by granule cells.','2013-10-27','NSRP'),(21938,44303,'axon collateral','C','Any of the smaller branches of an axon that emanate from the main axon cylinder.','2013-10-27','NSRP'),(21939,44304,'main axon','C','The main axonal trunk, as opposed to the collaterals.','2013-10-27','NSRP'),(21940,44305,'calyx of Held','C','The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.','2013-10-27','NSRP'),(21941,44306,'neuron projection terminus','C','The specialized, terminal region of a neuron projection such as an axon or a dendrite.','2013-10-27','NSRP'),(21942,44307,'dendritic branch','C','A dendrite arising from another dendrite.','2013-10-27','NSRP'),(21943,44308,'axonal spine','C','A spine that originates from the axon, usually from the initial segment.','2013-10-27','NSRP'),(21944,44309,'neuron spine','C','A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck.','2013-10-27','NSRP'),(21945,44310,'osmiophilic body','C','A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito.','2013-10-27','NSRP'),(21946,44311,'exoneme','C','A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte.','2013-10-27','NSRP'),(21947,44312,'crystalloid','C','A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation.','2013-10-27','NSRP'),(21948,44313,'protein K6-linked deubiquitination','P','A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein.','2013-10-27','NSRP'),(21949,44314,'protein K27-linked ubiquitination','P','A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein.','2013-10-27','NSRP'),(21950,44315,'protein secretion by the type VII secretion system','P','The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system.','2013-10-27','NSRP'),(21951,44316,'cone cell pedicle','C','A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL).','2013-10-27','NSRP'),(21952,44317,'rod spherule','C','A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body.','2013-10-27','NSRP'),(21953,44318,'L-aspartate:fumarate oxidoreductase activity','F','Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate.','2013-10-27','NSRP'),(21954,44319,'wound healing, spreading of cells','P','The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.','2013-10-27','NSRP'),(21955,44320,'cellular response to leptin stimulus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.','2013-10-27','NSRP'),(21956,44321,'response to leptin stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].','2013-10-27','NSRP'),(21957,44322,'endoplasmic reticulum quality control compartment','C','A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins.','2013-10-27','NSRP'),(21958,44323,'retinoic acid-responsive element binding','F','Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind.','2013-10-27','NSRP'),(21959,44324,'regulation of transcription involved in anterior/posterior axis specification','P','Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis.','2013-10-27','NSRP'),(21960,44325,'ion channel binding','F','Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.','2013-10-27','NSRP'),(21961,44326,'dendritic spine neck','C','Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine.','2013-10-27','NSRP'),(21962,44327,'dendritic spine head','C','Distal part of the dendritic spine, that carries the post-synaptic density.','2013-10-27','NSRP'),(21963,44328,'canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration.','2013-10-27','NSRP'),(21964,44329,'canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion.','2013-10-27','NSRP'),(21965,44330,'canonical Wnt receptor signaling pathway involved in positive regulation of wound healing','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing.','2013-10-27','NSRP'),(21966,44331,'cell-cell adhesion mediated by cadherin','P','The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.','2013-10-27','NSRP'),(21967,44332,'Wnt receptor signaling pathway involved in dorsal/ventral axis specification','P','The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis.','2013-10-27','NSRP'),(21968,44333,'Wnt receptor signaling pathway involved in digestive tract morphogenesis','P','The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract.','2013-10-27','NSRP'),(21969,44334,'canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition.','2013-10-27','NSRP'),(21970,44335,'canonical Wnt receptor signaling pathway involved in neural crest cell differentiation','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation.','2013-10-27','NSRP'),(21971,44336,'canonical Wnt receptor signaling pathway involved in negative regulation of apoptotic process','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process.','2013-10-27','NSRP'),(21972,44337,'canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process.','2013-10-27','NSRP'),(21973,44338,'canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation.','2013-10-27','NSRP'),(21974,44339,'canonical Wnt receptor signaling pathway involved in osteoblast differentiation','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation.','2013-10-27','NSRP'),(21975,44340,'canonical Wnt receptor signaling pathway involved in regulation of cell proliferation','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation.','2013-10-27','NSRP'),(21976,44341,'sodium-dependent phosphate transport','P','The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions.','2013-10-27','NSRP'),(21977,44342,'type B pancreatic cell proliferation','P','The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin.','2013-10-27','NSRP'),(21978,44343,'canonical Wnt receptor signaling pathway involved in regulation of type B pancreatic cell proliferation','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin.','2013-10-27','NSRP'),(21979,44344,'cellular response to fibroblast growth factor stimulus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.','2013-10-27','NSRP'),(21980,44345,'stromal-epithelial cell signaling involved in prostate gland development','P','The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development.','2013-10-27','NSRP'),(21981,44346,'fibroblast apoptotic process','P','Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.','2013-10-27','NSRP'),(21982,44347,'cell wall polysaccharide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cell wall polysaccharides.','2013-10-27','NSRP'),(21983,44348,'plant-type cell wall cellulose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, which forms part of the cell wall.','2013-10-27','NSRP'),(21984,44349,'DNA excision','P','The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised.','2013-10-27','NSRP'),(21985,44350,'micropinocytosis','P','An endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm.','2013-10-27','NSRP'),(21986,44351,'macropinocytosis','P','An endocytosis process that results in the uptake of liquid material by cells from their external environment by the \'ruffling\' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size.','2013-10-27','NSRP'),(21987,44352,'pinosome','C','A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis.','2013-10-27','NSRP'),(21988,44353,'micropinosome','C','A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis.','2013-10-27','NSRP'),(21989,44354,'macropinosome','C','A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis.','2013-10-27','NSRP'),(21990,44355,'clearance of foreign intracellular DNA','P','A defense process that protects an organism from invading foreign DNA.','2013-10-27','NSRP'),(21991,44356,'clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine','P','A defense process that protects an organism from invading foreign DNA. The process begins by the deamination of foreign double-stranded DNA cytidines to uridines. These atypical DNA nucleosides are then converted by a uracil DNA glycosylase to abasic lesions, and the process ends with the degradation of the foreign DNA.','2013-10-27','NSRP'),(21992,44399,'multi-species biofilm formation','P','A process in which microorganisms of different species attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.','2013-10-27','NSRP'),(21993,44400,'multi-species biofilm formation on inanimate substrate','P','A process in which microorganisms of different species attach to and grow on an inanimate surface such as a rock or pipe and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.','2013-10-27','NSRP'),(21994,44401,'multi-species biofilm formation in or on host organism','P','A process in which microorganisms of different species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21995,44402,'competition with other organism','P','Any process in which an organism within a multispecies community gains an advantage in growth or survival over another organism of a different species in that community.','2013-10-27','NSRP'),(21996,44403,'symbiosis, encompassing mutualism through parasitism','P','An interaction between two organisms living together in more or less intimate association. The term host is usually used for the larger (macro) of the two members of a symbiosis. The smaller (micro) member is called the symbiont organism. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs.','2013-10-27','NSRP'),(21997,44405,'recognition of host','P','The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21998,44406,'adhesion to host','P','The attachment of an organism to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(21999,44407,'single-species biofilm formation in or on host organism','P','A process in which microorganisms of the same species attach to and grow in or on a surface in a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22000,44408,'growth or development of symbiont on or near host','P','OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism.','2013-10-27','NSRP'),(22001,44409,'entry into host','P','Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22002,44410,'entry into host through natural portals','P','Penetration by an organism into its host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22003,44411,'entry into host through host barriers','P','Penetration by an organism into its host organism via active breaching of the physical barriers of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22004,44412,'growth or development of symbiont in host','P','OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22005,44413,'avoidance of host defenses','P','Any process, either constitutive or induced, by which an organism evades, suppresses or tolerates the effects of its host organism\'s defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22006,44414,'suppression of host defenses','P','Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22007,44415,'evasion or tolerance of host defenses','P','Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism\'s defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22008,44416,'induction by symbiont of host defense response','P','The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22009,44417,'translocation of molecules into host','P','The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22010,44418,'translocation of DNA into host','P','The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(22011,44419,'interspecies interaction between organisms','P','Any process in which an organism has an effect on an organism of a different species.','2013-10-27','NSRP'),(22012,44420,'extracellular matrix part','C','Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants).','2013-10-27','NSRP'),(22013,44421,'extracellular region part','C','Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite.','2013-10-27','NSRP'),(22014,44422,'organelle part','C','Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane.','2013-10-27','NSRP'),(22015,44423,'virion part','C','Any constituent part of a virion, a complete fully infectious extracellular virus particle.','2013-10-27','NSRP'),(22016,44424,'intracellular part','C','Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.','2013-10-27','NSRP'),(22017,44425,'membrane part','C','Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.','2013-10-27','NSRP'),(22018,44426,'cell wall part','C','Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.','2013-10-27','NSRP'),(22019,44427,'chromosomal part','C','Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.','2013-10-27','NSRP'),(22020,44428,'nuclear part','C','Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated.','2013-10-27','NSRP'),(22021,44429,'mitochondrial part','C','Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.','2013-10-27','NSRP'),(22022,44430,'cytoskeletal part','C','Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice.','2013-10-27','NSRP'),(22023,44431,'Golgi apparatus part','C','Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack.','2013-10-27','NSRP'),(22024,44432,'endoplasmic reticulum part','C','Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae.','2013-10-27','NSRP'),(22025,44433,'cytoplasmic vesicle part','C','Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell.','2013-10-27','NSRP'),(22026,44434,'chloroplast part','C','Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.','2013-10-27','NSRP'),(22027,44435,'plastid part','C','Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.','2013-10-27','NSRP'),(22028,44436,'thylakoid part','C','Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms.','2013-10-27','NSRP'),(22029,44437,'vacuolar part','C','Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material.','2013-10-27','NSRP'),(22030,44438,'microbody part','C','Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).','2013-10-27','NSRP'),(22031,44439,'peroxisomal part','C','Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2).','2013-10-27','NSRP'),(22032,44440,'endosomal part','C','Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered.','2013-10-27','NSRP'),(22033,44441,'cilium part','C','Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.','2013-10-27','NSRP'),(22034,44442,'microtubule-based flagellum part','C','Any constituent part of a microtubule-based flagellum, a long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules. Examples of this component are found in Mus musculus.','2012-03-14','NSRP'),(22035,44443,'pilus part','C','Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.','2013-10-27','NSRP'),(22036,44444,'cytoplasmic part','C','Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.','2013-10-27','NSRP'),(22037,44445,'cytosolic part','C','Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components.','2013-10-27','NSRP'),(22038,44446,'intracellular organelle part','C','A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane.','2013-10-27','NSRP'),(22039,44447,'axoneme part','C','Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.','2013-10-27','NSRP'),(22040,44448,'cell cortex part','C','Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.','2013-10-27','NSRP'),(22041,44449,'contractile fiber part','C','Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.','2013-10-27','NSRP'),(22042,44450,'microtubule organizing center part','C','Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow.','2013-10-27','NSRP'),(22043,44451,'nucleoplasm part','C','Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.','2013-10-27','NSRP'),(22044,44452,'nucleolar part','C','Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis.','2013-10-27','NSRP'),(22045,44453,'nuclear membrane part','C','Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells.','2013-10-27','NSRP'),(22046,44454,'nuclear chromosome part','C','Any constituent part of a nuclear chromosome, a chromosome found in the nucleus of a eukaryotic cell.','2013-10-27','NSRP'),(22047,44455,'mitochondrial membrane part','C','Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.','2013-10-27','NSRP'),(22048,44456,'synapse part','C','Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.','2013-10-27','NSRP'),(22049,44457,'cell septum part','C','Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.','2013-10-27','NSRP'),(22050,44459,'plasma membrane part','C','Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.','2013-10-27','NSRP'),(22051,44460,'flagellum part','C','OBSOLETE. Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium.','2013-10-27','NSRP'),(22052,44461,'bacterial-type flagellum part','C','Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. Examples of this component are found in bacterial species.','2013-10-27','NSRP'),(22053,44462,'external encapsulating structure part','C','Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell.','2013-10-27','NSRP'),(22054,44463,'cell projection part','C','Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon.','2013-10-27','NSRP'),(22055,44464,'cell part','C','Any constituent part of a cell, the basic structural and functional unit of all organisms.','2013-10-27','NSRP'),(22056,45002,'double-strand break repair via single-strand annealing','P','Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5\' to 3\' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats.','2013-10-27','NSRP'),(22057,45003,'double-strand break repair via synthesis-dependent strand annealing','P','SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3\' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break.','2013-10-27','NSRP'),(22058,45004,'DNA replication proofreading','P','Correction of replication errors by DNA polymerase using a 3\'-5\' exonuclease activity.','2013-10-27','NSRP'),(22059,45005,'maintenance of fidelity involved in DNA-dependent DNA replication','P','A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair.','2013-10-27','NSRP'),(22060,45006,'DNA deamination','P','The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil.','2013-10-27','NSRP'),(22061,45007,'depurination','P','The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar.','2013-10-27','NSRP'),(22062,45008,'depyrimidination','P','The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar.','2013-10-27','NSRP'),(22063,45009,'chitosome','C','An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum.','2013-10-27','NSRP'),(22064,45010,'actin nucleation','P','The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament.','2013-10-27','NSRP'),(22065,45012,'MHC class II receptor activity','F','OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells (\'antigen-presenting cells\') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes.','2013-10-27','NSRP'),(22066,45013,'carbon catabolite repression of transcription','P','A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances.','2013-10-27','NSRP'),(22067,45014,'negative regulation of transcription by glucose','P','Any process involving glucose that stops, prevents or reduces the rate of transcription. The presence of glucose in the growth medium inhibits the synthesis of certain enzymes in bacteria growing on the medium. For example, transcription of some catabolic operons is under negative control by specific repressors and glucose is an anti-inducer of xylose utilization and glycerol kinase.','2013-10-27','NSRP'),(22068,45015,'HDEL sequence binding','F','Interacting selectively and non-covalently with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.','2013-10-27','NSRP'),(22069,45016,'mitochondrial magnesium ion transport','P','The transport of magnesium ions (Mg2+) into, out of or within a mitochondrion. Transport across the mitochondrial membranes is mediated by a mitochondrial inner membrane protein.','2013-10-27','NSRP'),(22070,45017,'glycerolipid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone.','2013-10-27','NSRP'),(22071,45018,'retrograde transport, vacuole to Golgi','P','The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment.','2013-10-27','NSRP'),(22072,45019,'negative regulation of nitric oxide biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.','2013-10-27','NSRP'),(22073,45020,'error-prone DNA repair','P','OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate.','2013-10-27','NSRP'),(22074,45021,'error-free DNA repair','P','OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways.','2013-10-27','NSRP'),(22075,45022,'early endosome to late endosome transport','P','The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.','2013-10-27','NSRP'),(22076,45023,'G0 to G1 transition','P','The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression.','2013-10-27','NSRP'),(22077,45024,'peptidyl-glutamyl peptide hydrolyzing enzyme activity','F','OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids.','2013-10-27','NSRP'),(22078,45025,'mitochondrial degradosome','C','A mitochondrial protein complex with 3\' to 5\' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer.','2013-10-27','NSRP'),(22079,45026,'plasma membrane fusion','P','The joining of two or more lipid bilayer membranes that surround a cell.','2013-10-27','NSRP'),(22080,45027,'DNA end binding','F','Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs).','2013-10-27','NSRP'),(22081,45028,'G-protein coupled purinergic nucleotide receptor activity','F','Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(22082,45029,'UDP-activated nucleotide receptor activity','F','Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP.','2013-10-27','NSRP'),(22083,45030,'UTP-activated nucleotide receptor activity','F','Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP.','2013-10-27','NSRP'),(22084,45031,'ATP-activated nucleotide receptor activity','F','Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ATP.','2013-10-27','NSRP'),(22085,45032,'ADP-activated nucleotide receptor activity','F','Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ADP.','2013-10-27','NSRP'),(22086,45033,'peroxisome inheritance','P','The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p.','2013-10-27','NSRP'),(22087,45034,'neuroblast division','P','OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell.','2013-10-27','NSRP'),(22088,45035,'sensory organ precursor cell division','P','The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron).','2013-10-27','NSRP'),(22089,45036,'protein targeting to chloroplast','P','The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved.','2013-10-27','NSRP'),(22090,45037,'protein import into chloroplast stroma','P','The import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import.','2013-10-27','NSRP'),(22091,45038,'protein import into chloroplast thylakoid membrane','P','The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma.','2013-10-27','NSRP'),(22092,45039,'protein import into mitochondrial inner membrane','P','The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane.','2013-10-27','NSRP'),(22093,45040,'protein import into mitochondrial outer membrane','P','The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.','2013-10-27','NSRP'),(22094,45041,'protein import into mitochondrial intermembrane space','P','The import of proteins into the space between the inner and outer mitochondrial membranes.','2013-10-27','NSRP'),(22095,45042,'protein import into mitochondrial intermembrane space, conservative','P','OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space.','2013-10-27','NSRP'),(22096,45045,'secretory pathway','P','OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane.','2013-10-27','NSRP'),(22097,45046,'protein import into peroxisome membrane','P','The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import.','2013-10-27','NSRP'),(22098,45047,'protein targeting to ER','P','The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane.','2013-10-27','NSRP'),(22099,45048,'protein insertion into ER membrane','P','The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.','2013-10-27','NSRP'),(22100,45049,'protein insertion into ER membrane by N-terminal cleaved signal sequence','P','A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER.','2013-10-27','NSRP'),(22101,45050,'protein insertion into ER membrane by stop-transfer membrane-anchor sequence','P','A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix.','2013-10-27','NSRP'),(22102,45051,'protein insertion into ER membrane by internal uncleaved signal-anchor sequence','P','A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences.','2013-10-27','NSRP'),(22103,45052,'protein insertion into ER membrane by GPI attachment sequence','P','A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule.','2013-10-27','NSRP'),(22104,45053,'protein retention in Golgi apparatus','P','The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known.','2013-10-27','NSRP'),(22105,45054,'constitutive secretory pathway','P','A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space.','2013-10-27','NSRP'),(22106,45055,'regulated secretory pathway','P','A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand.','2013-10-27','NSRP'),(22107,45056,'transcytosis','P','The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side.','2013-10-27','NSRP'),(22108,45057,'cisternal progression','P','The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna.','2013-10-27','NSRP'),(22109,45058,'T cell selection','P','The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation.','2013-10-27','NSRP'),(22110,45059,'positive thymic T cell selection','P','The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.','2013-10-27','NSRP'),(22111,45060,'negative thymic T cell selection','P','The process of elimination of immature T cells in the thymus which react strongly with self-antigens.','2013-10-27','NSRP'),(22112,45061,'thymic T cell selection','P','The process of T cell selection that occurs in the thymus.','2013-10-27','NSRP'),(22113,45062,'extrathymic T cell selection','P','The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus.','2013-10-27','NSRP'),(22114,45063,'T-helper 1 cell differentiation','P','The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.','2013-10-27','NSRP'),(22115,45064,'T-helper 2 cell differentiation','P','The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4.','2013-10-27','NSRP'),(22116,45065,'cytotoxic T cell differentiation','P','The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell.','2013-10-27','NSRP'),(22117,45066,'regulatory T cell differentiation','P','The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types.','2013-10-27','NSRP'),(22118,45067,'positive extrathymic T cell selection','P','The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.','2013-10-27','NSRP'),(22119,45068,'negative extrathymic T cell selection','P','The process of elimination of extrathymically maturing T cells which react strongly with self-antigens.','2013-10-27','NSRP'),(22120,45069,'regulation of viral genome replication','P','Any process that modulates the frequency, rate or extent of viral genome replication.','2013-10-27','NSRP'),(22121,45070,'positive regulation of viral genome replication','P','Any process that activates or increases the frequency, rate or extent of viral genome replication.','2013-10-27','NSRP'),(22122,45071,'negative regulation of viral genome replication','P','Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication.','2013-10-27','NSRP'),(22123,45072,'regulation of interferon-gamma biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.','2013-10-27','NSRP'),(22124,45073,'regulation of chemokine biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.','2013-10-27','NSRP'),(22125,45074,'regulation of interleukin-10 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10.','2013-10-27','NSRP'),(22126,45075,'regulation of interleukin-12 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.','2013-10-27','NSRP'),(22127,45076,'regulation of interleukin-2 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.','2013-10-27','NSRP'),(22128,45077,'negative regulation of interferon-gamma biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.','2013-10-27','NSRP'),(22129,45078,'positive regulation of interferon-gamma biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.','2013-10-27','NSRP'),(22130,45079,'negative regulation of chemokine biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.','2013-10-27','NSRP'),(22131,45080,'positive regulation of chemokine biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.','2013-10-27','NSRP'),(22132,45081,'negative regulation of interleukin-10 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10.','2013-10-27','NSRP'),(22133,45082,'positive regulation of interleukin-10 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10.','2013-10-27','NSRP'),(22134,45083,'negative regulation of interleukin-12 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.','2013-10-27','NSRP'),(22135,45084,'positive regulation of interleukin-12 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12.','2013-10-27','NSRP'),(22136,45085,'negative regulation of interleukin-2 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.','2013-10-27','NSRP'),(22137,45086,'positive regulation of interleukin-2 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2.','2013-10-27','NSRP'),(22138,45087,'innate immune response','P','Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.','2013-10-27','NSRP'),(22139,45088,'regulation of innate immune response','P','Any process that modulates the frequency, rate or extent of the innate immune response, the organism\'s first line of defense against infection.','2013-10-27','NSRP'),(22140,45089,'positive regulation of innate immune response','P','Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism\'s first line of defense against infection.','2013-10-27','NSRP'),(22141,45090,'retroviral genome replication','P','Any process involved in the replication of a retroviral genome. Retroviruses use RNA as their nucleic acid and reverse transcriptase to copy their genome into the DNA of the host cells chromosomes.','2013-10-27','NSRP'),(22142,45091,'regulation of retroviral genome replication','P','Any process that modulates the frequency, rate or extent of retroviral genome replication.','2013-10-27','NSRP'),(22143,45092,'interleukin-18 receptor complex','C','A protein complex that binds interleukin-18; comprises an alpha and a beta subunit.','2013-10-27','NSRP'),(22144,45093,'interleukin-18 alpha subunit binding','F','Interacting selectively and non-covalently with the alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells.','2013-10-27','NSRP'),(22145,45094,'interleukin-18 beta subunit binding','F','Interacting selectively and non-covalently with the beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a.','2013-10-27','NSRP'),(22146,45095,'keratin filament','C','A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins.','2013-10-27','NSRP'),(22147,45096,'acidic keratin','C','OBSOLETE. A type of intermediate filament.','2013-10-27','NSRP'),(22148,45097,'basic/neutral keratin','C','OBSOLETE. A type of intermediate filament.','2013-10-27','NSRP'),(22149,45098,'type III intermediate filament','C','A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments.','2013-10-27','NSRP'),(22150,45099,'vimentin','C','OBSOLETE. A type of intermediate filament.','2013-10-27','NSRP'),(22151,45100,'desmin','C','OBSOLETE. A type of intermediate filament.','2013-10-27','NSRP'),(22152,45101,'glial fibrillary acidic protein','C','OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes.','2013-10-27','NSRP'),(22153,45102,'peripherin','C','OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system.','2013-10-27','NSRP'),(22154,45103,'intermediate filament-based process','P','Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins.','2013-10-27','NSRP'),(22155,45104,'intermediate filament cytoskeleton organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.','2013-10-27','NSRP'),(22156,45105,'intermediate filament polymerization or depolymerization','P','Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament.','2013-10-27','NSRP'),(22157,45106,'intermediate filament depolymerization','P','Disassembly of intermediate filaments by the removal of component monomers from a filament.','2013-10-27','NSRP'),(22158,45107,'intermediate filament polymerization','P','Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain.','2013-10-27','NSRP'),(22159,45108,'regulation of intermediate filament polymerization or depolymerization','P','Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases.','2013-10-27','NSRP'),(22160,45109,'intermediate filament organization','P','Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking.','2013-10-27','NSRP'),(22161,45110,'intermediate filament bundle assembly','P','The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs.','2013-10-27','NSRP'),(22162,45111,'intermediate filament cytoskeleton','C','Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.','2013-10-27','NSRP'),(22163,45112,'integrin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules.','2013-10-27','NSRP'),(22164,45113,'regulation of integrin biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins.','2013-10-27','NSRP'),(22165,45114,'beta 2 integrin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit.','2013-10-27','NSRP'),(22166,45115,'regulation of beta 2 integrin biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.','2013-10-27','NSRP'),(22167,45116,'protein neddylation','P','Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein.','2013-10-27','NSRP'),(22168,45117,'azole transport','P','The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(22169,45118,'azole transporter activity','F','Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(22170,45119,'azole:hydrogen antiporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances.','2013-10-27','NSRP'),(22171,45120,'pronucleus','C','The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents.','2013-10-27','NSRP'),(22172,45121,'membrane raft','C','Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.','2013-10-27','NSRP'),(22173,45122,'aflatoxin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450.','2013-10-27','NSRP'),(22174,45123,'cellular extravasation','P','The migration of a leukocyte from the blood vessels into the surrounding tissue.','2013-10-27','NSRP'),(22175,45124,'regulation of bone resorption','P','Any process that modulates the frequency, rate or extent of bone tissue loss (resorption).','2013-10-27','NSRP'),(22176,45125,'bioactive lipid receptor activity','F','Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes.','2013-10-27','NSRP'),(22177,45127,'N-acetylglucosamine kinase activity','F','Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(22178,45128,'negative regulation of reciprocal meiotic recombination','P','Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate.','2013-10-27','NSRP'),(22179,45129,'NAD-independent histone deacetylase activity','F','Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone.','2013-10-27','NSRP'),(22180,45130,'keratan sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + keratan = adenosine 3\',5\'-bisphosphate + keratan 6\'-sulfate.','2013-10-27','NSRP'),(22181,45131,'pre-mRNA branch point binding','F','Interacting selectively and non-covalently with a pre-mRNA branch point sequence, located upstream of the 3\' splice site.','2013-10-27','NSRP'),(22182,45132,'meiotic chromosome segregation','P','The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle.','2013-10-27','NSRP'),(22183,45133,'2,3-dihydroxybenzoate 3,4-dioxygenase activity','F','Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+).','2013-10-27','NSRP'),(22184,45134,'uridine-diphosphatase activity','F','Catalysis of the reaction: UDP + H2O = UMP + phosphate.','2013-10-27','NSRP'),(22185,45135,'poly(beta-D-mannuronate) lyase activity','F','Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends.','2013-10-27','NSRP'),(22186,45136,'development of secondary sexual characteristics','P','The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion.','2013-10-27','NSRP'),(22187,45137,'development of primary sexual characteristics','P','The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion.','2013-10-27','NSRP'),(22188,45138,'tail tip morphogenesis','P','The process in which the anatomical structures of the male copulatory structure in nematodes are generated and organized. The copulatory apparatus is a specialized tail structure reshaped during late post-embryonic development, that includes a fan-like arrangement of nine pairs of chemosensory organs known as rays, sclerotized spicules, the gubernaculum, the hook sensillum, and associated musculature.','2013-10-27','NSRP'),(22189,45139,'copper sensitivity/resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(22190,45140,'inositol phosphoceramide synthase activity','F','Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide.','2013-10-27','NSRP'),(22191,45141,'meiotic telomere clustering','P','The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in homologous chromosome pairing and therefore progression through meiosis.','2013-10-27','NSRP'),(22192,45142,'triplex DNA binding','F','Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination.','2013-10-27','NSRP'),(22193,45143,'homologous chromosome segregation','P','The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets.','2013-10-27','NSRP'),(22194,45144,'meiotic sister chromatid segregation','P','The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle.','2013-10-27','NSRP'),(22195,45145,'single-stranded DNA 5\'-3\' exodeoxyribonuclease activity','F','Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5\' terminus of a single-stranded DNA molecule.','2013-10-27','NSRP'),(22196,45146,'initiation of acetate catabolic process by acetate','P','The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.','2013-10-27','NSRP'),(22197,45147,'regulation of initiation of acetate catabolic process by acetate','P','Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.','2013-10-27','NSRP'),(22198,45148,'tripeptide aminopeptidase activity','F','Catalysis of the release of the N-terminal residue from a tripeptide.','2013-10-27','NSRP'),(22199,45149,'acetoin metabolic process','P','The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source.','2013-10-27','NSRP'),(22200,45150,'acetoin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone.','2013-10-27','NSRP'),(22201,45151,'acetoin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone.','2013-10-27','NSRP'),(22202,45152,'antisigma factor binding','F','Interacting selectively and non-covalently with an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator.','2013-10-27','NSRP'),(22203,45153,'electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity','F','Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex.','2013-10-27','NSRP'),(22204,45154,'electron transporter, transferring electrons within cytochrome c oxidase complex activity','F','Enables the directed movement of electrons within the cytochrome c oxidase complex.','2013-10-27','NSRP'),(22205,45155,'electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity','F','Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex.','2013-10-27','NSRP'),(22206,45156,'electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity','F','Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis.','2013-10-27','NSRP'),(22207,45157,'electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity','F','Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis.','2013-10-27','NSRP'),(22208,45158,'electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity','F','Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II.','2013-10-27','NSRP'),(22209,45159,'myosin II binding','F','Interacting selectively and non-covalently with a class II myosin, any member of the class of \'conventional\' double-headed myosins that includes muscle myosin.','2013-10-27','NSRP'),(22210,45160,'myosin I complex','C','A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement.','2013-10-27','NSRP'),(22211,45161,'neuronal ion channel clustering','P','The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation.','2013-10-27','NSRP'),(22212,45162,'clustering of voltage-gated sodium channels','P','The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization.','2013-10-27','NSRP'),(22213,45163,'clustering of voltage-gated potassium channels','P','The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode.','2013-10-27','NSRP'),(22214,45164,'secretin (sensu Mammalia)','F','OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract.','2013-10-27','NSRP'),(22215,45165,'cell fate commitment','P','The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.','2013-10-27','NSRP'),(22216,45167,'asymmetric protein localization involved in cell fate determination','P','Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.','2013-10-27','NSRP'),(22217,45168,'cell-cell signaling involved in cell fate commitment','P','Signaling at long or short range between cells that results in the commitment of a cell to a certain fate.','2013-10-27','NSRP'),(22218,45169,'fusome','C','A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle.','2013-10-27','NSRP'),(22219,45170,'spectrosome','C','A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome.','2013-10-27','NSRP'),(22220,45171,'intercellular bridge','C','A direct link between the cytoplasms of sister cells that allows cells to communicate with one another. Germline intercellular bridges facilitate the passage of cytoplasmic components between cells during development. Intercellular bridges have also been found connecting somatic cells.','2013-10-27','NSRP'),(22221,45172,'germline ring canal','C','Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells.','2013-10-27','NSRP'),(22222,45173,'O-sialoglycoprotein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.','2013-10-27','NSRP'),(22223,45174,'glutathione dehydrogenase (ascorbate) activity','F','Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.','2013-10-27','NSRP'),(22224,45175,'basal protein localization','P','Any process in which a protein is transported to, or maintained in, basal regions of the cell.','2013-10-27','NSRP'),(22225,45176,'apical protein localization','P','Any process in which a protein is transported to, or maintained in, apical regions of the cell.','2013-10-27','NSRP'),(22226,45177,'apical part of cell','C','The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.','2013-10-27','NSRP'),(22227,45178,'basal part of cell','C','The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue.','2013-10-27','NSRP'),(22228,45179,'apical cortex','C','The region that lies just beneath the plasma membrane on the apical edge of a cell.','2013-10-27','NSRP'),(22229,45180,'basal cortex','C','The region that lies just beneath the plasma membrane on the basal edge of a cell.','2013-10-27','NSRP'),(22230,45181,'glutamate synthase activity, NAD(P)H as acceptor','F','Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+.','2013-10-27','NSRP'),(22231,45182,'translation regulator activity','F','Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.','2013-10-27','NSRP'),(22232,45183,'translation factor activity, non-nucleic acid binding','F','A translation regulator activity that does not involve binding to nucleic acids.','2013-10-27','NSRP'),(22233,45184,'establishment of protein localization','P','The directed movement of a protein to a specific location.','2013-10-27','NSRP'),(22234,45185,'maintenance of protein location','P','Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away.','2013-10-27','NSRP'),(22235,45186,'zonula adherens assembly','P','Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.','2013-10-27','NSRP'),(22236,45187,'regulation of circadian sleep/wake cycle, sleep','P','Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.','2013-10-27','NSRP'),(22237,45188,'regulation of circadian sleep/wake cycle, non-REM sleep','P','Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep.','2013-10-27','NSRP'),(22238,45189,'connective tissue growth factor biosynthetic process','P','The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta.','2013-10-27','NSRP'),(22239,45190,'isotype switching','P','The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5\' of each constant region gene segment in the immunoglobulin heavy chain locus.','2013-10-27','NSRP'),(22240,45191,'regulation of isotype switching','P','Any process that modulates the frequency, rate or extent of isotype switching.','2013-10-27','NSRP'),(22241,45192,'low-density lipoprotein catabolic process','P','OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats.','2013-10-27','NSRP'),(22242,45193,'acetylated low-density lipoprotein catabolic process','P','OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins.','2013-10-27','NSRP'),(22243,45194,'oxidized low-density lipoprotein catabolic process','P','OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins.','2013-10-27','NSRP'),(22244,45195,'gallstone formation','P','OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile.','2013-10-27','NSRP'),(22245,45196,'establishment or maintenance of neuroblast polarity','P','Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.','2013-10-27','NSRP'),(22246,45197,'establishment or maintenance of epithelial cell apical/basal polarity','P','Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.','2013-10-27','NSRP'),(22247,45198,'establishment of epithelial cell apical/basal polarity','P','The specification and formation of the apicobasal polarity of an epithelial cell.','2013-10-27','NSRP'),(22248,45199,'maintenance of epithelial cell apical/basal polarity','P','The maintenance of the apicobasal polarity of an epithelial cell.','2013-10-27','NSRP'),(22249,45200,'establishment of neuroblast polarity','P','The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.','2013-10-27','NSRP'),(22250,45201,'maintenance of neuroblast polarity','P','The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system.','2013-10-27','NSRP'),(22251,45202,'synapse','C','The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.','2013-10-27','NSRP'),(22252,45203,'integral to cell outer membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the external outer membrane of the cell. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(22253,45204,'MAPK export from nucleus','P','The directed movement of a MAP kinase from the nucleus to the cytoplasm.','2013-10-27','NSRP'),(22254,45205,'MAPK transporter activity','F','OBSOLETE. Enables the directed movement of MAP kinase into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(22255,45206,'MAPK phosphatase transporter activity','F','OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(22256,45208,'MAPK phosphatase export from nucleus','P','The directed movement of a MAPK phosphatase from the nucleus to the cytoplasm.','2013-10-27','NSRP'),(22257,45209,'MAPK phosphatase export from nucleus, leptomycin B sensitive','P','Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm.','2013-10-27','NSRP'),(22258,45210,'FasL biosynthetic process','P','The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines.','2013-10-27','NSRP'),(22259,45211,'postsynaptic membrane','C','A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters across the synaptic cleft and transmit the signal to the postsynaptic membrane.','2013-10-27','NSRP'),(22260,45212,'neurotransmitter receptor biosynthetic process','P','The chemical reactions and pathways resulting in the formation of neurotransmitter receptors.','2013-10-27','NSRP'),(22261,45213,'neurotransmitter receptor metabolic process','P','The chemical reactions and pathways involving neurotransmitter receptors.','2013-10-27','NSRP'),(22262,45214,'sarcomere organization','P','The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.','2013-10-27','NSRP'),(22263,45216,'cell-cell junction organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells.','2013-10-27','NSRP'),(22264,45217,'cell-cell junction maintenance','P','The maintenance of junctions between cells.','2013-10-27','NSRP'),(22265,45218,'zonula adherens maintenance','P','Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells.','2013-10-27','NSRP'),(22266,45219,'regulation of FasL biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.','2013-10-27','NSRP'),(22267,45220,'positive regulation of FasL biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.','2013-10-27','NSRP'),(22268,45221,'negative regulation of FasL biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.','2013-10-27','NSRP'),(22269,45222,'CD4 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions.','2013-10-27','NSRP'),(22270,45223,'regulation of CD4 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.','2013-10-27','NSRP'),(22271,45224,'positive regulation of CD4 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.','2013-10-27','NSRP'),(22272,45225,'negative regulation of CD4 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4.','2013-10-27','NSRP'),(22273,45226,'extracellular polysaccharide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures.','2013-10-27','NSRP'),(22274,45227,'capsule polysaccharide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi.','2013-10-27','NSRP'),(22275,45228,'slime layer polysaccharide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall.','2013-10-27','NSRP'),(22276,45229,'external encapsulating structure organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell.','2013-10-27','NSRP'),(22277,45230,'capsule organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi.','2013-10-27','NSRP'),(22278,45231,'slime layer organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell.','2013-10-27','NSRP'),(22279,45232,'S-layer organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria.','2013-10-27','NSRP'),(22280,45233,'natural killer cell receptor activity','F','OBSOLETE. A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family.','2013-10-27','NSRP'),(22281,45234,'protein palmitoleylation','P','The covalent attachment of a palmitoleyl group to a protein.','2013-10-27','NSRP'),(22282,45236,'CXCR chemokine receptor binding','F','Interacting selectively and non-covalently with a chemokine receptor in the CXCR family.','2013-10-27','NSRP'),(22283,45237,'CXCR1 chemokine receptor binding','F','Interacting selectively and non-covalently with the CXCR1 chemokine receptor.','2013-10-27','NSRP'),(22284,45238,'CXCR2 chemokine receptor binding','F','Interacting selectively and non-covalently with the CXCR2 chemokine receptor.','2013-10-27','NSRP'),(22285,45239,'tricarboxylic acid cycle enzyme complex','C','Any of the heteromeric enzymes that act in the TCA cycle.','2013-10-27','NSRP'),(22286,45240,'dihydrolipoyl dehydrogenase complex','C','A protein complex that possesses alpha-ketoglutarate dehydrogenase activity.','2013-10-27','NSRP'),(22287,45241,'cytosolic alpha-ketoglutarate dehydrogenase complex','C','Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity.','2013-10-27','NSRP'),(22288,45242,'isocitrate dehydrogenase complex (NAD+)','C','Complex that possesses isocitrate dehydrogenase (NAD+) activity.','2013-10-27','NSRP'),(22289,45243,'cytosolic isocitrate dehydrogenase complex (NAD+)','C','Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity.','2013-10-27','NSRP'),(22290,45244,'succinate-CoA ligase complex (GDP-forming)','C','A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP.','2013-10-27','NSRP'),(22291,45246,'cytosolic tricarboxylic acid cycle enzyme complex','C','Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle.','2013-10-27','NSRP'),(22292,45247,'cytosolic electron transfer flavoprotein complex','C','A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors.','2013-10-27','NSRP'),(22293,45248,'cytosolic oxoglutarate dehydrogenase complex','C','A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).','2013-10-27','NSRP'),(22294,45249,'cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex','C','A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.','2013-10-27','NSRP'),(22295,45250,'cytosolic pyruvate dehydrogenase complex','C','Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order.','2013-10-27','NSRP'),(22296,45251,'electron transfer flavoprotein complex','C','A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system.','2013-10-27','NSRP'),(22297,45252,'oxoglutarate dehydrogenase complex','C','A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2).','2013-10-27','NSRP'),(22298,45253,'pyruvate dehydrogenase (lipoamide) phosphatase complex','C','A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.','2013-10-27','NSRP'),(22299,45254,'pyruvate dehydrogenase complex','C','Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).','2013-10-27','NSRP'),(22300,45257,'succinate dehydrogenase complex (ubiquinone)','C','The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration.','2013-10-27','NSRP'),(22301,45258,'plasma membrane succinate dehydrogenase complex (ubiquinone)','C','The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration.','2013-10-27','NSRP'),(22302,45259,'proton-transporting ATP synthase complex','C','A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient.','2013-10-27','NSRP'),(22303,45260,'plasma membrane proton-transporting ATP synthase complex','C','A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species.','2013-10-27','NSRP'),(22304,45261,'proton-transporting ATP synthase complex, catalytic core F(1)','C','The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled.','2013-10-27','NSRP'),(22305,45262,'plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)','C','The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species.','2013-10-27','NSRP'),(22306,45263,'proton-transporting ATP synthase complex, coupling factor F(o)','C','All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins.','2013-10-27','NSRP'),(22307,45264,'plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)','C','All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins.','2013-10-27','NSRP'),(22308,45265,'proton-transporting ATP synthase, stator stalk','C','One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core.','2013-10-27','NSRP'),(22309,45266,'plasma membrane proton-transporting ATP synthase, stator stalk','C','One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species.','2013-10-27','NSRP'),(22310,45267,'proton-transporting ATP synthase, catalytic core','C','The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase.','2013-10-27','NSRP'),(22311,45268,'plasma membrane proton-transporting ATP synthase, catalytic core','C','The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species.','2013-10-27','NSRP'),(22312,45269,'proton-transporting ATP synthase, central stalk','C','One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis.','2013-10-27','NSRP'),(22313,45270,'plasma membrane proton-transporting ATP synthase, central stalk','C','One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species.','2013-10-27','NSRP'),(22314,45271,'respiratory chain complex I','C','Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex.','2013-10-27','NSRP'),(22315,45272,'plasma membrane respiratory chain complex I','C','A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species.','2013-10-27','NSRP'),(22316,45273,'respiratory chain complex II','C','A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain.','2013-10-27','NSRP'),(22317,45274,'plasma membrane respiratory chain complex II','C','A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species.','2013-10-27','NSRP'),(22318,45275,'respiratory chain complex III','C','A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species.','2013-10-27','NSRP'),(22319,45276,'plasma membrane respiratory chain complex III','C','A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species.','2013-10-27','NSRP'),(22320,45277,'respiratory chain complex IV','C','A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).','2013-10-27','NSRP'),(22321,45278,'plasma membrane respiratory chain complex IV','C','A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in bacterial species.','2013-10-27','NSRP'),(22322,45281,'succinate dehydrogenase complex','C','A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones.','2013-10-27','NSRP'),(22323,45282,'plasma membrane succinate dehydrogenase complex','C','A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species.','2013-10-27','NSRP'),(22324,45283,'fumarate reductase complex','C','A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)).','2013-10-27','NSRP'),(22325,45284,'plasma membrane fumarate reductase complex','C','A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in bacterial species.','2013-10-27','NSRP'),(22326,45289,'luciferin monooxygenase activity','F','Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation.','2013-10-27','NSRP'),(22327,45290,'D-arabinose 1-dehydrogenase [NAD(P)+] activity','F','Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+.','2013-10-27','NSRP'),(22328,45291,'mRNA trans splicing, SL addition','P','The joining together of two independently transcribed RNAs, where the one that provides the 5\' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5\'-end of the acceptor RNA molecule which provides the mRNA body.','2013-10-27','NSRP'),(22329,45292,'mRNA cis splicing, via spliceosome','P','The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.','2013-10-27','NSRP'),(22330,45293,'mRNA editing complex','C','A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes.','2013-10-27','NSRP'),(22331,45294,'alpha-catenin binding','F','Interacting selectively and non-covalently with the alpha subunit of the catenin complex.','2013-10-27','NSRP'),(22332,45295,'gamma-catenin binding','F','Interacting selectively and non-covalently with the gamma subunit of the catenin complex.','2013-10-27','NSRP'),(22333,45296,'cadherin binding','F','Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.','2013-10-27','NSRP'),(22334,45297,'post-mating behavior','P','The specific behavior of an organism following mating.','2013-10-27','NSRP'),(22335,45298,'tubulin complex','C','A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.','2013-10-27','NSRP'),(22336,45299,'otolith mineralization','P','The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear.','2013-10-27','NSRP'),(22337,45300,'acyl-[acyl-carrier-protein] desaturase activity','F','Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin.','2013-10-27','NSRP'),(22338,45301,'tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity','F','Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin.','2013-10-27','NSRP'),(22339,45302,'choloylglycine hydrolase activity','F','Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine.','2013-10-27','NSRP'),(22340,45303,'diaminobutyrate-2-oxoglutarate transaminase activity','F','Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate.','2013-10-27','NSRP'),(22341,45304,'regulation of establishment of competence for transformation','P','Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome.','2013-10-27','NSRP'),(22342,45305,'regulator of establishment of competence for transformation activity','F','OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation.','2013-10-27','NSRP'),(22343,45306,'inhibitor of the establishment of competence for transformation activity','F','OBSOLETE. Inhibits the establishment of competence for transformation.','2013-10-27','NSRP'),(22344,45307,'activator of the establishment of competence for transformation activity','F','OBSOLETE. Activates the establishment of competence for transformation.','2013-10-27','NSRP'),(22345,45309,'protein phosphorylated amino acid binding','F','Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein.','2013-10-27','NSRP'),(22346,45310,'phosphoserine/phosphothreonine binding','F','OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein.','2013-10-27','NSRP'),(22347,45311,'invasive growth in response to pheromone','P','The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus.','2013-10-27','NSRP'),(22348,45312,'nor-spermidine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane.','2013-10-27','NSRP'),(22349,45313,'rhabdomere membrane biogenesis','P','A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane.','2013-10-27','NSRP'),(22350,45314,'regulation of compound eye photoreceptor development','P','Any process that modulates the frequency, rate or extent of compound eye photoreceptor development.','2013-10-27','NSRP'),(22351,45315,'positive regulation of compound eye photoreceptor development','P','Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development.','2013-10-27','NSRP'),(22352,45316,'negative regulation of compound eye photoreceptor development','P','Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development.','2013-10-27','NSRP'),(22353,45317,'equator specification','P','The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves.','2013-10-27','NSRP'),(22354,45319,'SRP-independent cotranslational protein-membrane targeting, translocation','P','OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition.','2013-10-27','NSRP'),(22355,45320,'chloroplast proton-transporting ATP synthase complex','C','A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation.','2013-10-27','NSRP'),(22356,45321,'leukocyte activation','P','A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(22357,45322,'unmethylated CpG binding','F','Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters.','2013-10-27','NSRP'),(22358,45323,'interleukin-1 receptor complex','C','A protein complex that binds interleukin-1; comprises an alpha and a beta subunit.','2013-10-27','NSRP'),(22359,45324,'late endosome to vacuole transport','P','The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.','2013-10-27','NSRP'),(22360,45325,'peptidyl-tryptophan hydroxylation','P','The hydroxylation of peptidyl-tryptophan, to form peptidyl-L-3-hydroxytryptophan.','2013-10-27','NSRP'),(22361,45326,'protein-DNA covalent cross-linking via the 3\'-end to peptidyl-tyrosine','P','The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4\'-(phospho-3\'-DNA)-L-tyrosine.','2013-10-27','NSRP'),(22362,45327,'protein-DNA covalent cross-linking via peptidyl-tyrosine','P','The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue.','2013-10-27','NSRP'),(22363,45328,'cytochrome P450 4A1-heme linkage','P','The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester.','2013-10-27','NSRP'),(22364,45329,'carnitine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.','2013-10-27','NSRP'),(22365,45330,'aspartyl esterase activity','F','Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue.','2013-10-27','NSRP'),(22366,45331,'coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity','F','OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate.','2013-10-27','NSRP'),(22367,45332,'phospholipid translocation','P','The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.','2013-10-27','NSRP'),(22368,45333,'cellular respiration','P','The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).','2013-10-27','NSRP'),(22369,45334,'clathrin-coated endocytic vesicle','C','A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance.','2013-10-27','NSRP'),(22370,45335,'phagocytic vesicle','C','A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.','2013-10-27','NSRP'),(22371,45336,'clathrin-coated phagocytic vesicle','C','A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.','2013-10-27','NSRP'),(22372,45337,'farnesyl diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of farnesyl diphosphate.','2013-10-27','NSRP'),(22373,45338,'farnesyl diphosphate metabolic process','P','The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation.','2013-10-27','NSRP'),(22374,45339,'farnesyl diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate.','2013-10-27','NSRP'),(22375,45340,'mercury ion binding','F','Interacting selectively and non-covalently with mercury (Hg) ions.','2013-10-27','NSRP'),(22376,45341,'MHC class I biosynthetic process','P','The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I.','2013-10-27','NSRP'),(22377,45342,'MHC class II biosynthetic process','P','The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II.','2013-10-27','NSRP'),(22378,45343,'regulation of MHC class I biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.','2013-10-27','NSRP'),(22379,45344,'negative regulation of MHC class I biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.','2013-10-27','NSRP'),(22380,45345,'positive regulation of MHC class I biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I.','2013-10-27','NSRP'),(22381,45346,'regulation of MHC class II biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.','2013-10-27','NSRP'),(22382,45347,'negative regulation of MHC class II biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.','2013-10-27','NSRP'),(22383,45348,'positive regulation of MHC class II biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II.','2013-10-27','NSRP'),(22384,45349,'interferon-alpha biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interferon-alpha.','2013-10-27','NSRP'),(22385,45350,'interferon-beta biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interferon-beta.','2013-10-27','NSRP'),(22386,45351,'type I interferon biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.','2013-10-27','NSRP'),(22387,45352,'interleukin-1 Type I receptor antagonist activity','F','Blocks the binding of interleukin-1 to interleukin-1 Type I receptors.','2013-10-27','NSRP'),(22388,45353,'interleukin-1 Type II receptor antagonist activity','F','Blocks the binding of interleukin-1 to interleukin-1 Type II receptors.','2013-10-27','NSRP'),(22389,45354,'regulation of interferon-alpha biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.','2013-10-27','NSRP'),(22390,45355,'negative regulation of interferon-alpha biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.','2013-10-27','NSRP'),(22391,45356,'positive regulation of interferon-alpha biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha.','2013-10-27','NSRP'),(22392,45357,'regulation of interferon-beta biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta.','2013-10-27','NSRP'),(22393,45358,'negative regulation of interferon-beta biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta.','2013-10-27','NSRP'),(22394,45359,'positive regulation of interferon-beta biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta.','2013-10-27','NSRP'),(22395,45360,'regulation of interleukin-1 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1.','2013-10-27','NSRP'),(22396,45361,'negative regulation of interleukin-1 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1.','2013-10-27','NSRP'),(22397,45362,'positive regulation of interleukin-1 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1.','2013-10-27','NSRP'),(22398,45363,'regulation of interleukin-11 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11.','2013-10-27','NSRP'),(22399,45364,'negative regulation of interleukin-11 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11.','2013-10-27','NSRP'),(22400,45365,'positive regulation of interleukin-11 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11.','2013-10-27','NSRP'),(22401,45366,'regulation of interleukin-13 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13.','2013-10-27','NSRP'),(22402,45367,'negative regulation of interleukin-13 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13.','2013-10-27','NSRP'),(22403,45368,'positive regulation of interleukin-13 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13.','2013-10-27','NSRP'),(22404,45369,'regulation of interleukin-14 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14.','2013-10-27','NSRP'),(22405,45370,'negative regulation of interleukin-14 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14.','2013-10-27','NSRP'),(22406,45371,'positive regulation of interleukin-14 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14.','2013-10-27','NSRP'),(22407,45372,'regulation of interleukin-15 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15.','2013-10-27','NSRP'),(22408,45373,'negative regulation of interleukin-15 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15.','2013-10-27','NSRP'),(22409,45374,'positive regulation of interleukin-15 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15.','2013-10-27','NSRP'),(22410,45375,'regulation of interleukin-16 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16.','2013-10-27','NSRP'),(22411,45376,'negative regulation of interleukin-16 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16.','2013-10-27','NSRP'),(22412,45377,'positive regulation of interleukin-16 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16.','2013-10-27','NSRP'),(22413,45378,'regulation of interleukin-17 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines.','2013-10-27','NSRP'),(22414,45379,'negative regulation of interleukin-17 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines.','2013-10-27','NSRP'),(22415,45380,'positive regulation of interleukin-17 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines.','2013-10-27','NSRP'),(22416,45381,'regulation of interleukin-18 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18.','2013-10-27','NSRP'),(22417,45382,'negative regulation of interleukin-18 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18.','2013-10-27','NSRP'),(22418,45383,'positive regulation of interleukin-18 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18.','2013-10-27','NSRP'),(22419,45384,'regulation of interleukin-19 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19.','2013-10-27','NSRP'),(22420,45385,'negative regulation of interleukin-19 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19.','2013-10-27','NSRP'),(22421,45386,'positive regulation of interleukin-19 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19.','2013-10-27','NSRP'),(22422,45387,'regulation of interleukin-20 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20.','2013-10-27','NSRP'),(22423,45388,'negative regulation of interleukin-20 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20.','2013-10-27','NSRP'),(22424,45389,'positive regulation of interleukin-20 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20.','2013-10-27','NSRP'),(22425,45390,'regulation of interleukin-21 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21.','2013-10-27','NSRP'),(22426,45391,'negative regulation of interleukin-21 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21.','2013-10-27','NSRP'),(22427,45392,'positive regulation of interleukin-21 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21.','2013-10-27','NSRP'),(22428,45393,'regulation of interleukin-22 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22.','2013-10-27','NSRP'),(22429,45394,'negative regulation of interleukin-22 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22.','2013-10-27','NSRP'),(22430,45395,'positive regulation of interleukin-22 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22.','2013-10-27','NSRP'),(22431,45396,'regulation of interleukin-23 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23.','2013-10-27','NSRP'),(22432,45397,'negative regulation of interleukin-23 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23.','2013-10-27','NSRP'),(22433,45398,'positive regulation of interleukin-23 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23.','2013-10-27','NSRP'),(22434,45399,'regulation of interleukin-3 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3.','2013-10-27','NSRP'),(22435,45400,'negative regulation of interleukin-3 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3.','2013-10-27','NSRP'),(22436,45401,'positive regulation of interleukin-3 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-3.','2013-10-27','NSRP'),(22437,45402,'regulation of interleukin-4 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4.','2013-10-27','NSRP'),(22438,45403,'negative regulation of interleukin-4 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4.','2013-10-27','NSRP'),(22439,45404,'positive regulation of interleukin-4 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-4.','2013-10-27','NSRP'),(22440,45405,'regulation of interleukin-5 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5.','2013-10-27','NSRP'),(22441,45406,'negative regulation of interleukin-5 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5.','2013-10-27','NSRP'),(22442,45407,'positive regulation of interleukin-5 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-5.','2013-10-27','NSRP'),(22443,45408,'regulation of interleukin-6 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.','2013-10-27','NSRP'),(22444,45409,'negative regulation of interleukin-6 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.','2013-10-27','NSRP'),(22445,45410,'positive regulation of interleukin-6 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-6.','2013-10-27','NSRP'),(22446,45411,'regulation of interleukin-7 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7.','2013-10-27','NSRP'),(22447,45412,'negative regulation of interleukin-7 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7.','2013-10-27','NSRP'),(22448,45413,'positive regulation of interleukin-7 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-7.','2013-10-27','NSRP'),(22449,45414,'regulation of interleukin-8 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.','2013-10-27','NSRP'),(22450,45415,'negative regulation of interleukin-8 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.','2013-10-27','NSRP'),(22451,45416,'positive regulation of interleukin-8 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-8.','2013-10-27','NSRP'),(22452,45417,'regulation of interleukin-9 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9.','2013-10-27','NSRP'),(22453,45418,'negative regulation of interleukin-9 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9.','2013-10-27','NSRP'),(22454,45419,'positive regulation of interleukin-9 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9.','2013-10-27','NSRP'),(22455,45420,'regulation of connective tissue growth factor biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor.','2013-10-27','NSRP'),(22456,45421,'negative regulation of connective tissue growth factor biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor.','2013-10-27','NSRP'),(22457,45422,'positive regulation of connective tissue growth factor biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor.','2013-10-27','NSRP'),(22458,45423,'regulation of granulocyte macrophage colony-stimulating factor biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor.','2013-10-27','NSRP'),(22459,45424,'negative regulation of granulocyte macrophage colony-stimulating factor biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor.','2013-10-27','NSRP'),(22460,45425,'positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor.','2013-10-27','NSRP'),(22461,45426,'quinone cofactor biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any quinone cofactor, such as menaquinone (vitamin K2), ubiquinone (coenzyme Q) or phylloquinone (vitamin K1).','2013-10-13','NSRP'),(22462,45427,'enzyme active site formation via (phospho-5\'-guanosine)-L-histidine','P','The transient guanylylation of peptidyl-histidine to form (phospho-5\'-guanosine)-L-histidine.','2013-10-27','NSRP'),(22463,45428,'regulation of nitric oxide biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.','2013-10-27','NSRP'),(22464,45429,'positive regulation of nitric oxide biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.','2013-10-27','NSRP'),(22465,45430,'chalcone isomerase activity','F','Catalysis of the reaction: a chalcone = a flavanone.','2013-10-27','NSRP'),(22466,45431,'flavonol synthase activity','F','Catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O.','2013-10-27','NSRP'),(22467,45433,'male courtship behavior, veined wing generated song production','P','The process during wing vibration where the male insect produces a species-specific acoustic signal called a love song.','2013-10-27','NSRP'),(22468,45434,'negative regulation of female receptivity, post-mating','P','Any process that stops, prevents or reduces the receptiveness of a female to male advances subsequent to mating.','2013-10-27','NSRP'),(22469,45435,'lycopene epsilon cyclase activity','F','Catalysis of the cyclization of an epsilon ring at one end of the lycopene molecule (psi, psi-carotene) to form delta-carotene (epsilon, psi-carotene).','2013-10-27','NSRP'),(22470,45436,'lycopene beta cyclase activity','F','Catalysis of the cyclization of beta rings at one or both ends of the lycopene molecule (psi, psi-carotene) to form gamma-carotene or the bicyclic beta-carotene (beta, beta-carotene), respectively.','2013-10-27','NSRP'),(22471,45437,'uridine nucleosidase activity','F','Catalysis of the reaction: H(2)O + uridine = ribofuranose + uracil.','2013-10-27','NSRP'),(22472,45438,'delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity','F','Catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol.','2013-10-27','NSRP'),(22473,45439,'isopenicillin-N epimerase activity','F','Catalysis of the reaction: isopenicillin N = penicillin N.','2013-10-27','NSRP'),(22474,45442,'deacetoxycephalosporin-C hydroxylase activity','F','Catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O(2) = CO(2) + deacetylcephalosporin C + succinate.','2013-10-27','NSRP'),(22475,45443,'juvenile hormone secretion','P','The regulated release of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis.','2013-10-27','NSRP'),(22476,45444,'fat cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.','2013-10-27','NSRP'),(22477,45445,'myoblast differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.','2013-10-27','NSRP'),(22478,45446,'endothelial cell differentiation','P','The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.','2013-10-27','NSRP'),(22479,45448,'mitotic cell cycle, embryonic','P','The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo.','2013-10-27','NSRP'),(22480,45450,'bicoid mRNA localization','P','Any process in which bicoid mRNA is transported to and maintained within the oocyte as part of the specification of the anterior/posterior axis.','2013-10-27','NSRP'),(22481,45451,'pole plasm oskar mRNA localization','P','Any process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.','2013-10-27','NSRP'),(22482,45453,'bone resorption','P','The process in which specialized cells known as osteoclasts degrade the organic and inorganic portions of bone, and endocytose and transport the degradation products.','2013-10-27','NSRP'),(22483,45454,'cell redox homeostasis','P','Any process that maintains the redox environment of a cell or compartment within a cell.','2013-10-27','NSRP'),(22484,45455,'ecdysteroid metabolic process','P','The chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids ubiquitous in insects and other arthropods, in which they initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females.','2013-10-27','NSRP'),(22485,45456,'ecdysteroid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development.','2013-10-27','NSRP'),(22486,45457,'ecdysteroid secretion','P','The regulated release of ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development.','2013-10-27','NSRP'),(22487,45458,'recombination within rDNA repeats','P','Genetic recombination within the DNA of the genes coding for ribosomal RNA.','2013-10-27','NSRP'),(22488,45459,'iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide','P','The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl triiron tetrasulfide.','2013-10-27','NSRP'),(22489,45460,'sterigmatocystin metabolic process','P','The chemical reactions and pathways involving sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.','2013-10-27','NSRP'),(22490,45461,'sterigmatocystin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds.','2013-10-27','NSRP'),(22491,45462,'trichothecene 3-O-acetyltransferase activity','F','Catalysis of the 3-O-acetylation of a trichothecene. Trichothecenes are sesquiterpene epoxide mycotoxins that act as potent inhibitors of eukaryotic protein synthesis.','2013-10-27','NSRP'),(22492,45463,'R8 cell development','P','The process whose specific outcome is the progression of the R8 photoreceptor over time, from its formation to the mature structure. The R8 photoreceptor is the founding receptor of each ommatidium.','2013-10-27','NSRP'),(22493,45464,'R8 cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into an R8 cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(22494,45465,'R8 cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of the R8 photoreceptor.','2013-10-27','NSRP'),(22495,45466,'R7 cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of the R7 photoreceptor.','2013-10-27','NSRP'),(22496,45467,'R7 cell development','P','The process whose specific outcome is the progression of the R7 photoreceptor over time, from its formation to the mature structure. The R7 photoreceptor is the last photoreceptor to develop in the ommatidium.','2013-10-27','NSRP'),(22497,45468,'regulation of R8 cell spacing in compound eye','P','Any process that ensures that the R8 cells are selected in a precise progressive pattern so that they are evenly spaced throughout the eye disc.','2013-10-27','NSRP'),(22498,45469,'negative regulation of R8 cell spacing in compound eye','P','Any process that stops or prevents the correct R8 cell spacing pattern in a compound eye.','2013-10-27','NSRP'),(22499,45470,'R8 cell-mediated photoreceptor organization','P','The regionalization process that coordinates the recruitment and organization of other non-R8 photoreceptors by the R8 photoreceptor.','2013-10-27','NSRP'),(22500,45471,'response to ethanol','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.','2013-10-27','NSRP'),(22501,45472,'response to ether','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ether stimulus.','2013-10-27','NSRP'),(22502,45473,'response to ethanol (sensu Insecta)','P','OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.','2013-10-27','NSRP'),(22503,45474,'response to ether (sensu Insecta)','P','OBSOLETE. A change in state or activity of an insect (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ether stimulus.','2013-10-27','NSRP'),(22504,45475,'locomotor rhythm','P','The rhythm of the locomotor activity of an organism during its 24 hour activity cycle.','2013-10-27','NSRP'),(22505,45476,'nurse cell apoptotic process','P','Any apoptotic process in a nurse cell. During late oogenesis, following the transfer of substances from the nurse cells to the oocyte, nurse cell remnants are cleared from the egg chamber by apoptotic process.','2013-10-27','NSRP'),(22506,45477,'regulation of nurse cell apoptotic process','P','Any process that modulates the frequency, rate or extent of nurse cell apoptotic process.','2013-10-27','NSRP'),(22507,45478,'fusome organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome, a large intracellular spectrin-rich structure found in insect germline cells and mammalian hematopoietic cells.','2013-10-27','NSRP'),(22508,45479,'vesicle targeting to fusome','P','The recruitment of vesicles to the fusome. The vesicles become the fusome tubule network and are necessary for the assembly of the fusome.','2013-10-27','NSRP'),(22509,45480,'galactose oxidase activity','F','Catalysis of the reaction: D-galactose + O2 = D-galacto-hexodialdose + hydrogen peroxide.','2013-10-27','NSRP'),(22510,45481,'6-endo-hydroxycineole dehydrogenase activity','F','Catalysis of the reaction: 6-endo-hydroxycineole + NAD(+) = 6-oxocineole + H(+) + NADH.','2013-10-27','NSRP'),(22511,45482,'trichodiene synthase activity','F','Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + trichodiene.','2013-10-27','NSRP'),(22512,45483,'aristolochene synthase activity','F','Catalysis of the reaction: trans,trans-farnesyl diphosphate = aristolochene + diphosphate.','2013-10-27','NSRP'),(22513,45484,'L-lysine 6-transaminase activity','F','Catalysis of the reaction: 2-oxoglutarate + L-lysine = L-glutamate + allysine.','2013-10-27','NSRP'),(22514,45485,'omega-6 fatty acid desaturase activity','F','Catalysis of the introduction of an omega-6 double bond into the fatty acid hydrocarbon chain.','2013-10-27','NSRP'),(22515,45486,'naringenin 3-dioxygenase activity','F','Catalysis of the reaction: naringenin + 2-oxoglutarate + O2 = dihydrokaempferol + succinate + CO2.','2013-10-27','NSRP'),(22516,45487,'gibberellin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.','2013-10-27','NSRP'),(22517,45488,'pectin metabolic process','P','The chemical reactions and pathways involving pectin, a group of galacturonic acid-containing, water-soluble colloidal carbohydrates of high molecular weight and of net negative charge.','2013-10-27','NSRP'),(22518,45489,'pectin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.','2013-10-27','NSRP'),(22519,45490,'pectin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues.','2013-10-27','NSRP'),(22520,45491,'xylan metabolic process','P','The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone.','2013-10-27','NSRP'),(22521,45492,'xylan biosynthetic process','P','The chemical reactions and pathways resulting in the formation of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.','2013-10-27','NSRP'),(22522,45493,'xylan catabolic process','P','The chemical reactions and pathways resulting in the breakdown of xylan, a polymer containing a beta-1,4-linked D-xylose backbone.','2013-10-27','NSRP'),(22523,45494,'photoreceptor cell maintenance','P','Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.','2013-10-27','NSRP'),(22524,45495,'pole plasm','C','Differentiated cytoplasm associated with a pole (animal, vegetal, anterior, or posterior) of an oocyte, egg or early embryo.','2013-10-27','NSRP'),(22525,45496,'male analia development','P','The process whose specific outcome is the progression of the analia of the male over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(22526,45497,'female analia development','P','The process whose specific outcome is the progression of the analia of the female over time, from formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(22527,45498,'sex comb development','P','The process whose specific outcome is the progression of the sex comb over time, from its formation to the mature structure. The sex combs are the male specific chaetae located on the prothoracic tarsal segment of the prothoracic leg.','2013-10-27','NSRP'),(22528,45499,'chemorepellent activity','F','Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.','2013-10-27','NSRP'),(22529,45500,'sevenless signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(22530,45501,'regulation of sevenless signaling pathway','P','Any process that modulates the frequency, rate or extent of the sevenless signaling pathway.','2013-10-27','NSRP'),(22531,45502,'dynein binding','F','Interacting selectively and non-covalently with dynein, the multisubunit protein complex that is associated with microtubules.','2013-10-27','NSRP'),(22532,45503,'dynein light chain binding','F','Interacting selectively and non-covalently with a light chain of the dynein complex.','2013-10-27','NSRP'),(22533,45504,'dynein heavy chain binding','F','Interacting selectively and non-covalently with a heavy chain of the dynein complex.','2013-10-27','NSRP'),(22534,45505,'dynein intermediate chain binding','F','Interacting selectively and non-covalently with an intermediate chain of the dynein complex.','2013-10-27','NSRP'),(22535,45506,'interleukin-24 receptor activity','F','Combining with interleukin-24 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(22536,45507,'interleukin-25 receptor activity','F','Combining with interleukin-25 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(22537,45508,'interleukin-26 receptor activity','F','Combining with interleukin-26 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(22538,45509,'interleukin-27 receptor activity','F','Combining with interleukin-27 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(22539,45510,'interleukin-24 binding','F','Interacting selectively and non-covalently with interleukin-24.','2013-10-27','NSRP'),(22540,45511,'interleukin-25 binding','F','Interacting selectively and non-covalently with interleukin-25.','2013-10-27','NSRP'),(22541,45512,'interleukin-26 binding','F','Interacting selectively and non-covalently with interleukin-26.','2013-10-27','NSRP'),(22542,45513,'interleukin-27 binding','F','Interacting selectively and non-covalently with interleukin-27.','2013-10-27','NSRP'),(22543,45514,'interleukin-16 receptor binding','F','Interacting selectively and non-covalently with the interleukin-16 receptor.','2013-10-27','NSRP'),(22544,45515,'interleukin-18 receptor binding','F','Interacting selectively and non-covalently with the interleukin-18 receptor.','2013-10-27','NSRP'),(22545,45516,'interleukin-19 receptor binding','F','Interacting selectively and non-covalently with the interleukin-19 receptor.','2013-10-27','NSRP'),(22546,45517,'interleukin-20 receptor binding','F','Interacting selectively and non-covalently with the interleukin-20 receptor.','2013-10-27','NSRP'),(22547,45518,'interleukin-22 receptor binding','F','Interacting selectively and non-covalently with the interleukin-22 receptor.','2013-10-27','NSRP'),(22548,45519,'interleukin-23 receptor binding','F','Interacting selectively and non-covalently with the interleukin-23 receptor.','2013-10-27','NSRP'),(22549,45520,'interleukin-24 receptor binding','F','Interacting selectively and non-covalently with the interleukin-24 receptor.','2013-10-27','NSRP'),(22550,45521,'interleukin-25 receptor binding','F','Interacting selectively and non-covalently with the interleukin-25 receptor.','2013-10-27','NSRP'),(22551,45522,'interleukin-26 receptor binding','F','Interacting selectively and non-covalently with the interleukin-26 receptor.','2013-10-27','NSRP'),(22552,45523,'interleukin-27 receptor binding','F','Interacting selectively and non-covalently with the interleukin-27 receptor.','2013-10-27','NSRP'),(22553,45524,'interleukin-24 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-24.','2013-10-27','NSRP'),(22554,45525,'interleukin-25 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-25.','2013-10-27','NSRP'),(22555,45526,'interleukin-26 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-26.','2013-10-27','NSRP'),(22556,45527,'interleukin-27 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-27.','2013-10-27','NSRP'),(22557,45528,'regulation of interleukin-24 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24.','2013-10-27','NSRP'),(22558,45529,'regulation of interleukin-25 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25.','2013-10-27','NSRP'),(22559,45530,'regulation of interleukin-26 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26.','2013-10-27','NSRP'),(22560,45531,'regulation of interleukin-27 biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27.','2013-10-27','NSRP'),(22561,45532,'negative regulation of interleukin-24 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24.','2013-10-27','NSRP'),(22562,45533,'negative regulation of interleukin-25 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25.','2013-10-27','NSRP'),(22563,45534,'negative regulation of interleukin-26 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26.','2013-10-27','NSRP'),(22564,45535,'negative regulation of interleukin-27 biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27.','2013-10-27','NSRP'),(22565,45536,'positive regulation of interleukin-24 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-24.','2013-10-27','NSRP'),(22566,45537,'positive regulation of interleukin-25 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-25.','2013-10-27','NSRP'),(22567,45538,'positive regulation of interleukin-26 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-26.','2013-10-27','NSRP'),(22568,45539,'positive regulation of interleukin-27 biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-27.','2013-10-27','NSRP'),(22569,45540,'regulation of cholesterol biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.','2013-10-27','NSRP'),(22570,45541,'negative regulation of cholesterol biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.','2013-10-27','NSRP'),(22571,45542,'positive regulation of cholesterol biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cholesterol.','2013-10-27','NSRP'),(22572,45543,'gibberellin 2-beta-dioxygenase activity','F','Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 2-beta-hydroxygibberellin + succinate + CO2.','2013-10-27','NSRP'),(22573,45544,'gibberellin 20-oxidase activity','F','Catalysis of the oxidation of C-20 gibberellins to form the corresponding C-19 lactones.','2013-10-27','NSRP'),(22574,45545,'syndecan binding','F','Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.','2013-10-27','NSRP'),(22575,45547,'dehydrodolichyl diphosphate synthase activity','F','Catalysis of the condensation of isopentenyl diphosphate and farnesyl diphosphate in the cis-configuration to form dehydrodolichyl diphosphate.','2013-10-27','NSRP'),(22576,45548,'phenylalanine ammonia-lyase activity','F','Catalysis of the reaction: L-phenylalanine = NH(4)(+) + trans-cinnamate.','2013-10-27','NSRP'),