(5679,7070,'negative regulation of transcription from RNA polymerase II promoter during mitosis','P','Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis.','2013-10-27','NSRP'),(5680,7071,'negative regulation of transcription from RNA polymerase III promoter during mitosis','P','Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis.','2013-10-27','NSRP'),(5681,7072,'positive regulation of transcription on exit from mitosis','P','Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.','2013-10-27','NSRP'),(5682,7073,'positive regulation of transcription on exit from mitosis, from RNA polymerase I promoter','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.','2013-10-27','NSRP'),(5683,7074,'positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.','2013-10-27','NSRP'),(5684,7075,'positive regulation of transcription on exit from mitosis, from RNA polymerase III promoter','P','Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.','2013-10-27','NSRP'),(5685,7076,'mitotic chromosome condensation','P','The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells.','2013-10-27','NSRP'),(5686,7077,'mitotic nuclear envelope disassembly','P','The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs.','2013-10-27','NSRP'),(5687,7078,'lamin depolymerization','P','The cell cycle process in which lamin is depolymerized.','2013-10-27','NSRP'),(5688,7079,'mitotic chromosome movement towards spindle pole','P','The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis.','2013-10-27','NSRP'),(5689,7080,'mitotic metaphase plate congression','P','The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis.','2013-10-27','NSRP'),(5690,7081,'mitotic sister-chromatid adhesion release','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5691,7083,'mitotic chromosome decondensation','P','The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells.','2013-10-27','NSRP'),(5692,7084,'mitotic nuclear envelope reassembly','P','The cell cycle process that results in reformation of the nuclear envelope during mitotic cell division.','2013-10-27','NSRP'),(5693,7085,'nuclear membrane vesicle binding to chromatin','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5694,7086,'vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly','P','The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly.','2013-10-27','NSRP'),(5695,7087,'mitotic nuclear pore complex reassembly','P','The cell cycle process in which nuclear pore complexes reform during mitotic cell division.','2013-10-27','NSRP'),(5696,7088,'regulation of mitosis','P','Any process that modulates the frequency, rate or extent of mitosis.','2013-10-27','NSRP'),(5697,7089,'traversing start control point of mitotic cell cycle','P','A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity.','2013-10-27','NSRP'),(5698,7090,'regulation of S phase of mitotic cell cycle','P','OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle.','2013-10-27','NSRP'),(5699,7091,'metaphase/anaphase transition of mitotic cell cycle','P','The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins.','2013-10-27','NSRP'),(5700,7092,'activation of mitotic anaphase-promoting complex activity','P','Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex that regulates the mitotic metaphase/anaphase transition.','2013-10-27','NSRP'),(5701,7093,'mitotic cell cycle checkpoint','P','A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.','2013-10-27','NSRP'),(5702,7094,'mitotic spindle assembly checkpoint','P','A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.','2013-10-27','NSRP'),(5703,7095,'mitotic G2 DNA damage checkpoint','P','A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.','2013-10-27','NSRP'),(5704,7096,'regulation of exit from mitosis','P','Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.','2013-10-27','NSRP'),(5705,7097,'nuclear migration','P','The directed movement of the nucleus.','2013-10-27','NSRP'),(5706,7098,'centrosome cycle','P','The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.','2013-10-27','NSRP'),(5707,7099,'centriole replication','P','The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type.','2013-10-27','NSRP'),(5708,7100,'mitotic centrosome separation','P','Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.','2013-10-27','NSRP'),(5709,7101,'male meiosis centrosome cycle','P','Centrosome duplication and separation in the context of a meiotic cell cycle in a male organism.','2013-10-27','NSRP'),(5710,7103,'spindle pole body duplication associated with nuclear envelope','P','Construction of a new spindle pole body adjacent to the existing spindle pole body occurring at or near the nuclear envelope; usually occurs about the time of bud emergence. An example of this is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(5711,7105,'cytokinesis, site selection','P','The process of marking the place where cytokinesis will occur.','2013-10-27','NSRP'),(5712,7106,'cytokinesis, protein recruitment','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5713,7107,'membrane addition at site of cytokinesis','P','Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion.','2013-10-27','NSRP'),(5714,7108,'cytokinesis, initiation of separation','P','The process involved in starting cell separation.','2013-10-27','NSRP'),(5715,7109,'cytokinesis, completion of separation','P','The process of finishing cell separation, which results in two physically separated cells.','2013-10-27','NSRP'),(5716,7110,'meiosis I cytokinesis','P','A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells.','2013-10-27','NSRP'),(5717,7111,'meiosis II cytokinesis','P','A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells.','2013-10-27','NSRP'),(5718,7112,'male meiosis cytokinesis','P','A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.','2013-10-27','NSRP'),(5719,7113,'endomitotic cell cycle','P','A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.','2013-10-27','NSRP'),(5720,7114,'cell budding','P','A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell.','2013-10-27','NSRP'),(5721,7115,'bud site selection/establishment of cell polarity (sensu Saccharomyces)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5722,7116,'regulation of cell budding','P','Any process that modulates the frequency, rate or extent of the formation and growth of cell buds.','2013-10-27','NSRP'),(5723,7117,'budding cell bud growth','P','The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.','2013-10-27','NSRP'),(5724,7118,'budding cell apical bud growth','P','Growth at the tip of a bud, in a cell that reproduces by budding.','2013-10-27','NSRP'),(5725,7119,'budding cell isotropic bud growth','P','Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding.','2013-10-27','NSRP'),(5726,7120,'axial cellular bud site selection','P','The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell.','2013-10-27','NSRP'),(5727,7121,'bipolar cellular bud site selection','P','The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell.','2013-10-27','NSRP'),(5728,7122,'loss of asymmetric budding','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5729,7123,'bud scar accumulation','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5730,7124,'pseudohyphal growth','P','A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate.','2013-10-27','NSRP'),(5731,7125,'invasive growth','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5732,7126,'meiosis','P','A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle. A meiotic cell cycle is the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations.','2013-10-27','NSRP'),(5733,7127,'meiosis I','P','A cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.','2013-10-27','NSRP'),(5734,7128,'meiotic prophase I','P','The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.','2013-10-27','NSRP'),(5735,7129,'synapsis','P','The cell cycle process in which the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate.','2013-10-27','NSRP'),(5736,7130,'synaptonemal complex assembly','P','The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination.','2013-10-27','NSRP'),(5737,7131,'reciprocal meiotic recombination','P','The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity.','2013-10-27','NSRP'),(5738,7132,'meiotic metaphase I','P','The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I.','2013-10-27','NSRP'),(5739,7133,'meiotic anaphase I','P','The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I.','2013-10-27','NSRP'),(5740,7134,'meiotic telophase I','P','The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.','2013-10-27','NSRP'),(5741,7135,'meiosis II','P','A cell cycle process comprising the steps by which a cell progresses through the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome.','2013-10-27','NSRP'),(5742,7136,'meiotic prophase II','P','The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell.','2013-10-27','NSRP'),(5743,7137,'meiotic metaphase II','P','The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II.','2013-10-27','NSRP'),(5744,7138,'meiotic anaphase II','P','The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II.','2013-10-27','NSRP'),(5745,7139,'meiotic telophase II','P','The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts.','2013-10-27','NSRP'),(5746,7140,'male meiosis','P','A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle in the male germline.','2013-10-27','NSRP'),(5747,7141,'male meiosis I','P','A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline.','2013-10-27','NSRP'),(5748,7142,'male meiosis II','P','A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline.','2013-10-27','NSRP'),(5749,7143,'female meiosis','P','A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle in the female germline.','2013-10-27','NSRP'),(5750,7144,'female meiosis I','P','The cell cycle process in which the first meiotic division occurs in the female germline.','2013-10-27','NSRP'),(5751,7146,'meiotic recombination nodule assembly','P','During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes.','2013-10-27','NSRP'),(5752,7147,'female meiosis II','P','The cell cycle process in which the second meiotic division occurs in the female germline.','2013-10-27','NSRP'),(5753,7149,'colony morphology','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5754,7150,'growth pattern','P','OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances.','2013-10-27','NSRP'),(5755,7154,'cell communication','P','Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.','2013-10-27','NSRP'),(5756,7155,'cell adhesion','P','The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.','2013-10-27','NSRP'),(5757,7156,'homophilic cell adhesion','P','The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell.','2013-10-27','NSRP'),(5758,7157,'heterophilic cell-cell adhesion','P','The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.','2013-10-27','NSRP'),(5759,7158,'neuron cell-cell adhesion','P','The attachment of a neuron to another cell via adhesion molecules.','2013-10-27','NSRP'),(5760,7159,'leukocyte cell-cell adhesion','P','The attachment of a leukocyte to another cell via adhesion molecules.','2013-10-27','NSRP'),(5761,7160,'cell-matrix adhesion','P','The binding of a cell to the extracellular matrix via adhesion molecules.','2013-10-27','NSRP'),(5762,7161,'calcium-independent cell-matrix adhesion','P','The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction.','2013-10-27','NSRP'),(5763,7162,'negative regulation of cell adhesion','P','Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.','2013-10-27','NSRP'),(5764,7163,'establishment or maintenance of cell polarity','P','Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.','2013-10-27','NSRP'),(5765,7164,'establishment of tissue polarity','P','Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.','2013-10-27','NSRP'),(5766,7165,'signal transduction','P','The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.','2013-10-27','NSRP'),(5767,7166,'cell surface receptor signaling pathway','P','A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5768,7167,'enzyme linked receptor protein signaling pathway','P','Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5769,7168,'receptor guanylyl cyclase signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5770,7169,'transmembrane receptor protein tyrosine kinase signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5771,7170,'transmembrane receptor protein tyrosine kinase ligand binding','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5772,7171,'activation of transmembrane receptor protein tyrosine kinase activity','P','Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity.','2013-10-27','NSRP'),(5773,7172,'signal complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell.','2013-10-27','NSRP'),(5774,7173,'epidermal growth factor receptor signaling pathway','P','A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5775,7174,'epidermal growth factor catabolic process','P','The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor.','2013-10-27','NSRP'),(5776,7175,'negative regulation of epidermal growth factor-activated receptor activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.','2013-10-27','NSRP'),(5777,7176,'regulation of epidermal growth factor-activated receptor activity','P','Any process that modulates the frequency, rate or extent of EGF-activated receptor activity.','2013-10-27','NSRP'),(5778,7178,'transmembrane receptor protein serine/threonine kinase signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5779,7179,'transforming growth factor beta receptor signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5780,7180,'transforming growth factor beta ligand binding to type II receptor','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5781,7181,'transforming growth factor beta receptor complex assembly','P','The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex.','2013-10-27','NSRP'),(5782,7182,'common-partner SMAD protein phosphorylation','P','The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus.','2013-10-27','NSRP'),(5783,7183,'SMAD protein complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins.','2013-10-27','NSRP'),(5784,7184,'SMAD protein import into nucleus','P','The directed movement of a SMAD proteins from the cytoplasm into the nucleus. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.','2013-10-27','NSRP'),(5785,7185,'transmembrane receptor protein tyrosine phosphatase signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5786,7186,'G-protein coupled receptor signaling pathway','P','A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5787,7187,'G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger','P','The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide.','2013-10-27','NSRP'),(5788,7188,'adenylate cyclase-modulating G-protein coupled receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(5789,7189,'adenylate cyclase-activating G-protein coupled receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(5790,7190,'activation of adenylate cyclase activity','P','Any process that initiates the activity of the inactive enzyme adenylate cyclase.','2013-10-27','NSRP'),(5791,7191,'adenylate cyclase-activating dopamine receptor signaling pathway','P','The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(5792,7192,'adenylate cyclase-activating serotonin receptor signaling pathway','P','The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(5793,7193,'adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(5794,7194,'negative regulation of adenylate cyclase activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity.','2013-10-27','NSRP'),(5795,7195,'adenylate cyclase-inhibiting dopamine receptor signaling pathway','P','The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(5796,7196,'adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(5797,7197,'adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(5798,7198,'adenylate cyclase-inhibiting serotonin receptor signaling pathway','P','The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(5799,7199,'G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger','P','The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP).','2013-10-27','NSRP'),(5800,7200,'phospholipase C-activating G-protein coupled receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).','2013-10-27','NSRP'),(5801,7201,'G-protein dissociation','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5802,7202,'activation of phospholipase C activity','P','The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.','2013-10-27','NSRP'),(5803,7203,'phosphatidylinositol-4,5-bisphosphate hydrolysis','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5804,7204,'elevation of cytosolic calcium ion concentration','P','Any process that increases the concentration of calcium ions in the cytosol.','2013-10-27','NSRP'),(5805,7205,'protein kinase C-activating G-protein coupled receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).','2013-10-27','NSRP'),(5806,7206,'phospholipase C-activating G-protein coupled glutamate receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).','2013-10-27','NSRP'),(5807,7207,'phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).','2013-10-27','NSRP'),(5808,7208,'phospholipase C-activating serotonin receptor signaling pathway','P','The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).','2013-10-27','NSRP'),(5809,7209,'phospholipase C-activating tachykinin receptor signaling pathway','P','The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).','2013-10-27','NSRP'),(5810,7210,'serotonin receptor signaling pathway','P','The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands.','2013-10-27','NSRP'),(5811,7211,'octopamine or tyramine signaling pathway','P','The series of molecular signals generated as a consequence of octopamine or tyramine binding to a cell surface receptor. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters.','2013-10-27','NSRP'),(5812,7212,'dopamine receptor signaling pathway','P','The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands.','2013-10-27','NSRP'),(5813,7213,'G-protein coupled acetylcholine receptor signaling pathway','P','Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5814,7214,'gamma-aminobutyric acid signaling pathway','P','The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor.','2013-10-27','NSRP'),(5815,7215,'glutamate receptor signaling pathway','P','A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5816,7216,'G-protein coupled glutamate receptor signaling pathway','P','A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5817,7217,'tachykinin receptor signaling pathway','P','The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor.','2013-10-27','NSRP'),(5818,7218,'neuropeptide signaling pathway','P','The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor.','2013-10-27','NSRP'),(5819,7219,'Notch signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5820,7220,'Notch receptor processing','P','The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor.','2013-10-27','NSRP'),(5821,7221,'positive regulation of transcription of Notch receptor target','P','The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain.','2013-10-27','NSRP'),(5822,7223,'Wnt receptor signaling pathway, calcium modulating pathway','P','The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).','2013-10-27','NSRP'),(5823,7224,'smoothened signaling pathway','P','A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.','2013-10-27','NSRP'),(5824,7225,'patched ligand maturation','P','The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups.','2013-10-27','NSRP'),(5825,7227,'signal transduction downstream of smoothened','P','The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.','2013-10-27','NSRP'),(5826,7228,'positive regulation of hh target transcription factor activity','P','Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited.','2013-10-27','NSRP'),(5827,7229,'integrin-mediated signaling pathway','P','A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(5828,7230,'calcium-o-sensing receptor pathway','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5829,7231,'osmosensory signaling pathway','P','The series of molecular signals initiated in response to osmotic change.','2013-10-27','NSRP'),(5830,7232,'osmosensory signaling pathway via Sho1 osmosensor','P','A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system.','2013-10-27','NSRP'),(5831,7234,'osmosensory signaling via phosphorelay pathway','P','A series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system.','2013-10-27','NSRP'),(5832,7235,'activation of Ypd1 protein','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5833,7236,'activation of Ssk1 protein','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5834,7237,'activation of Ssk2/Ssk22 proteins','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5835,7238,'activation of Pbs2','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5836,7239,'activation of Hog1','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5837,7240,'nuclear translocation of Hog1','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5838,7241,'inactivation of Hog1','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5839,7243,'intracellular protein kinase cascade','P','A series of reactions in which a signal is passed on to downstream proteins within the cell by sequential protein phosphorylation and activation of the cascade components.','2013-10-27','NSRP'),(5840,7244,'MAPKKK cascade (mating sensu Saccharomyces)','P','OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces.','2013-10-27','NSRP'),(5841,7245,'activation of MAPKKK (mating sensu Saccharomyces)','P','OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces.','2013-10-27','NSRP'),(5842,7246,'activation of MAPKK (mating sensu Saccharomyces)','P','OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces.','2013-10-27','NSRP'),(5843,7247,'activation of MAPK (mating sensu Saccharomyces)','P','OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces.','2013-10-27','NSRP'),(5844,7248,'nuclear translocation of MAPK (mating sensu Saccharomyces)','P','OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces.','2013-10-27','NSRP'),(5845,7249,'I-kappaB kinase/NF-kappaB cascade','P','The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.','2013-10-27','NSRP'),(5846,7250,'activation of NF-kappaB-inducing kinase activity','P','The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.','2013-10-27','NSRP'),(5847,7251,'activation of the inhibitor of kappa kinase','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5848,7252,'I-kappaB phosphorylation','P','The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.','2013-10-27','NSRP'),(5849,7253,'cytoplasmic sequestering of NF-kappaB','P','The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus.','2013-10-27','NSRP'),(5850,7254,'JNK cascade','P','An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.','2013-10-27','NSRP'),(5851,7256,'activation of JNKK activity','P','The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress.','2013-10-27','NSRP'),(5852,7257,'activation of JUN kinase activity','P','The initiation of the activity of the inactive enzyme JUN kinase (JNK).','2013-10-27','NSRP'),(5853,7258,'JUN phosphorylation','P','The process of introducing a phosphate group into a JUN protein.','2013-10-27','NSRP'),(5854,7259,'JAK-STAT cascade','P','Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The JAK-STAT cascade begins with activation of STAT proteins by members of the JAK family of tyrosine kinases, proceeds through dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.','2013-10-27','NSRP'),(5855,7260,'tyrosine phosphorylation of STAT protein','P','The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.','2013-10-27','NSRP'),(5856,7261,'JAK-induced STAT protein dimerization','P','OBSOLETE. The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases.','2013-10-27','NSRP'),(5857,7262,'STAT protein import into nucleus','P','The directed movement of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases.','2013-10-27','NSRP'),(5858,7263,'nitric oxide mediated signal transduction','P','Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.','2013-10-27','NSRP'),(5859,7264,'small GTPase mediated signal transduction','P','Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.','2013-10-27','NSRP'),(5860,7265,'Ras protein signal transduction','P','A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.','2013-10-27','NSRP'),(5861,7266,'Rho protein signal transduction','P','A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.','2013-10-27','NSRP'),(5862,7267,'cell-cell signaling','P','Any process that mediates the transfer of information from one cell to another.','2013-10-27','NSRP'),(5863,7268,'synaptic transmission','P','The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.','2013-10-27','NSRP'),(5864,7269,'neurotransmitter secretion','P','The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.','2013-10-27','NSRP'),(5865,7270,'neuron-neuron synaptic transmission','P','The process of communication from a neuron to another neuron across a synapse.','2013-10-27','NSRP'),(5866,7271,'synaptic transmission, cholinergic','P','The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse using the neurotransmitter acetylcholine.','2013-10-27','NSRP'),(5867,7272,'ensheathment of neurons','P','The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.','2013-10-27','NSRP'),(5868,7273,'regulation of synapse','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5869,7274,'neuromuscular synaptic transmission','P','The process of communication from a neuron to a muscle, across a synapse.','2013-10-27','NSRP'),(5870,7275,'multicellular organismal development','P','The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).','2013-10-27','NSRP'),(5871,7276,'gamete generation','P','The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.','2013-10-27','NSRP'),(5872,7277,'pole cell development','P','The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure.','2013-10-27','NSRP'),(5873,7278,'pole cell fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(5874,7279,'pole cell formation','P','Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells.','2013-10-27','NSRP'),(5875,7280,'pole cell migration','P','The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form.','2013-10-27','NSRP'),(5876,7281,'germ cell development','P','The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.','2013-10-27','NSRP'),(5877,7282,'cystoblast division','P','Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells.','2013-10-27','NSRP'),(5878,7283,'spermatogenesis','P','The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.','2013-10-27','NSRP'),(5879,7284,'spermatogonial cell division','P','The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes).','2013-10-27','NSRP'),(5880,7285,'primary spermatocyte growth','P','The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis.','2013-10-27','NSRP'),(5881,7286,'spermatid development','P','The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.','2013-10-27','NSRP'),(5882,7287,'Nebenkern assembly','P','Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern.','2013-10-27','NSRP'),(5883,7288,'sperm axoneme assembly','P','The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.','2013-10-27','NSRP'),(5884,7289,'spermatid nucleus differentiation','P','The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.','2013-10-27','NSRP'),(5885,7290,'spermatid nucleus elongation','P','The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation.','2013-10-27','NSRP'),(5886,7291,'sperm individualization','P','The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.','2013-10-27','NSRP'),(5887,7292,'female gamete generation','P','Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.','2013-10-27','NSRP'),(5888,7293,'germarium-derived egg chamber formation','P','Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5889,7294,'germarium-derived oocyte fate determination','P','The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5890,7295,'growth of a germarium-derived egg chamber','P','Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5891,7296,'vitellogenesis','P','The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.','2013-10-27','NSRP'),(5892,7297,'ovarian follicle cell migration','P','The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5893,7298,'border follicle cell migration','P','The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5894,7299,'ovarian follicle cell-cell adhesion','P','The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5895,7300,'ovarian nurse cell to oocyte transport','P','Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5896,7301,'female germline ring canal formation','P','Assembly of the intercellular bridges that connect the germ-line cells of a female cyst.','2013-10-27','NSRP'),(5897,7302,'nurse cell nucleus anchoring','P','Attachment of the nurse cell nucleus to the plasma membrane.','2013-10-27','NSRP'),(5898,7303,'cytoplasmic transport, nurse cell to oocyte','P','The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte.','2013-10-27','NSRP'),(5899,7304,'chorion-containing eggshell formation','P','The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5900,7305,'vitelline membrane formation involved in chorion-containing eggshell formation','P','Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5901,7306,'eggshell chorion assembly','P','Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell.','2013-10-27','NSRP'),(5902,7307,'eggshell chorion gene amplification','P','Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster.','2013-10-27','NSRP'),(5903,7308,'oocyte construction','P','The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5904,7309,'oocyte axis specification','P','The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5905,7310,'oocyte dorsal/ventral axis specification','P','The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5906,7311,'maternal specification of dorsal/ventral axis, oocyte, germ-line encoded','P','Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5907,7312,'oocyte nucleus migration involved in oocyte dorsal/ventral axis specification','P','The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5908,7313,'maternal specification of dorsal/ventral axis, oocyte, soma encoded','P','Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5909,7314,'oocyte anterior/posterior axis specification','P','Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5910,7315,'pole plasm assembly','P','Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5911,7316,'pole plasm RNA localization','P','Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5912,7317,'regulation of pole plasm oskar mRNA localization','P','Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm.','2013-10-27','NSRP'),(5913,7318,'pole plasm protein localization','P','Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(5914,7319,'negative regulation of oskar mRNA translation','P','Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein.','2013-10-27','NSRP'),(5915,7320,'insemination','P','The introduction of semen or sperm into the genital tract of a female.','2013-10-27','NSRP'),(5916,7321,'sperm displacement','P','The physical displacement of sperm stored from previous mating encounters.','2013-10-27','NSRP'),(5917,7323,'peptide pheromone maturation','P','The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(5918,7329,'positive regulation of transcription from RNA polymerase II promoter by pheromones','P','Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(5919,7336,'bilateral process','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5920,7337,'unilateral process','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5921,7338,'single fertilization','P','The union of male and female gametes to form a zygote.','2013-10-27','NSRP'),(5922,7339,'binding of sperm to zona pellucida','P','The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.','2013-10-27','NSRP'),(5923,7340,'acrosome reaction','P','The discharge, by sperm, of a single, anterior secretory granule following the sperm\'s attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg.','2013-10-27','NSRP'),(5924,7341,'penetration of zona pellucida','P','The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm.','2013-10-27','NSRP'),(5925,7342,'fusion of sperm to egg plasma membrane','P','The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head.','2013-10-27','NSRP'),(5926,7343,'egg activation','P','The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm.','2013-10-27','NSRP'),(5927,7344,'pronuclear fusion','P','The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome.','2013-10-27','NSRP'),(5928,7345,'embryogenesis and morphogenesis','P','OBSOLETE. Formation and development of an embryo and its organized structures.','2013-10-27','NSRP'),(5929,7346,'regulation of mitotic cell cycle','P','Any process that modulates the rate or extent of progress through the mitotic cell cycle.','2013-10-27','NSRP'),(5930,7347,'regulation of preblastoderm mitotic cell cycle','P','A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle.','2013-10-27','NSRP'),(5931,7348,'regulation of syncytial blastoderm mitotic cell cycle','P','A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle.','2013-10-27','NSRP'),(5932,7349,'cellularization','P','The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.','2013-10-27','NSRP'),(5933,7350,'blastoderm segmentation','P','The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo.','2013-10-27','NSRP'),(5934,7351,'tripartite regional subdivision','P','Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions.','2013-10-27','NSRP'),(5935,7352,'zygotic specification of dorsal/ventral axis','P','The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote.','2013-10-27','NSRP'),(5936,7353,'ventral/lateral system','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5937,7354,'zygotic determination of anterior/posterior axis, embryo','P','The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade.','2013-10-27','NSRP'),(5938,7355,'anterior region determination','P','Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product.','2013-10-27','NSRP'),(5939,7356,'thorax and anterior abdomen determination','P','Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product.','2013-10-27','NSRP'),(5940,7357,'positive regulation of central gap gene transcription','P','The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products.','2013-10-27','NSRP'),(5941,7358,'establishment of central gap gene boundaries','P','Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel.','2013-10-27','NSRP'),(5942,7359,'posterior abdomen determination','P','The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes.','2013-10-27','NSRP'),(5943,7360,'positive regulation of posterior gap gene transcription','P','The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene.','2013-10-27','NSRP'),(5944,7361,'establishment of posterior gap gene boundaries','P','Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps.','2013-10-27','NSRP'),(5945,7362,'terminal region determination','P','Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products.','2013-10-27','NSRP'),(5946,7363,'positive regulation of terminal gap gene transcription','P','The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes.','2013-10-27','NSRP'),(5947,7364,'establishment of terminal gap gene boundary','P','Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes.','2013-10-27','NSRP'),(5948,7365,'periodic partitioning','P','The regionalization process that divides the spatial regions of an embryo into serially repeated regions.','2013-10-27','NSRP'),(5949,7366,'periodic partitioning by pair rule gene','P','Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities.','2013-10-27','NSRP'),(5950,7367,'segment polarity determination','P','Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.','2013-10-27','NSRP'),(5951,7368,'determination of left/right symmetry','P','The establishment of an organism\'s body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.','2013-10-27','NSRP'),(5952,7369,'gastrulation','P','A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.','2013-10-27','NSRP'),(5953,7370,'ventral furrow formation','P','Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation.','2013-10-27','NSRP'),(5954,7371,'ventral midline determination','P','The regionalization process in which the area where the ventral midline will form is specified.','2013-10-27','NSRP'),(5955,7374,'posterior midgut invagination','P','Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior.','2013-10-27','NSRP'),(5956,7375,'anterior midgut invagination','P','Internalization of the anterior midgut into the interior of the embryo.','2013-10-27','NSRP'),(5957,7376,'cephalic furrow formation','P','Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome.','2013-10-27','NSRP'),(5958,7377,'germ-band extension','P','Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further.','2013-10-27','NSRP'),(5959,7378,'amnioserosa formation','P','Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift.','2013-10-27','NSRP'),(5960,7379,'segment specification','P','The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes.','2013-10-27','NSRP'),(5961,7380,'specification of segmental identity, head','P','The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.','2013-10-27','NSRP'),(5962,7381,'specification of segmental identity, labial segment','P','The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.','2013-10-27','NSRP'),(5963,7382,'specification of segmental identity, maxillary segment','P','The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.','2013-10-27','NSRP'),(5964,7383,'specification of segmental identity, antennal segment','P','The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.','2013-10-27','NSRP'),(5965,7384,'specification of segmental identity, thorax','P','The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.','2013-10-27','NSRP'),(5966,7385,'specification of segmental identity, abdomen','P','The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.','2013-10-27','NSRP'),(5967,7386,'compartment pattern specification','P','The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation.','2013-10-27','NSRP'),(5968,7387,'anterior compartment pattern formation','P','The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo.','2013-10-27','NSRP'),(5969,7388,'posterior compartment specification','P','The process involved in the specification of cell identity in the posterior compartments of the segmented embryo.','2013-10-27','NSRP'),(5970,7389,'pattern specification process','P','Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.','2013-10-27','NSRP'),(5971,7390,'germ-band shortening','P','The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo.','2013-10-27','NSRP'),(5972,7391,'dorsal closure','P','The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.','2013-10-27','NSRP'),(5973,7392,'initiation of dorsal closure','P','Events that occur at the start of dorsal closure.','2013-10-27','NSRP'),(5974,7393,'dorsal closure, leading edge cell fate determination','P','The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(5975,7394,'dorsal closure, elongation of leading edge cells','P','The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis.','2013-10-27','NSRP'),(5976,7395,'dorsal closure, spreading of leading edge cells','P','Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa.','2013-10-27','NSRP'),(5977,7396,'suture of dorsal opening','P','Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole.','2013-10-27','NSRP'),(5978,7397,'histogenesis and organogenesis','P','OBSOLETE. The generation of organized tissues or of whole organs.','2013-10-27','NSRP'),(5979,7398,'ectoderm development','P','The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation.','2013-10-27','NSRP'),(5980,7399,'nervous system development','P','The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.','2013-10-27','NSRP'),(5981,7400,'neuroblast fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(5982,7401,'pan-neural process','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(5983,7402,'ganglion mother cell fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(5984,7403,'glial cell fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(5985,7405,'neuroblast proliferation','P','The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.','2013-10-27','NSRP'),(5986,7406,'negative regulation of neuroblast proliferation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts.','2013-10-27','NSRP'),(5987,7407,'neuroblast activation','P','A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand.','2013-10-27','NSRP'),(5988,7409,'axonogenesis','P','Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells.','2013-10-27','NSRP'),(5989,7411,'axon guidance','P','The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(5990,7412,'axon target recognition','P','The process in which an axon recognizes and binds to a set of cells with which it may form stable connections.','2013-10-27','NSRP'),(5991,7413,'axonal fasciculation','P','The collection of axons into a bundle of rods, known as a fascicle.','2013-10-27','NSRP'),(5992,7414,'axonal defasciculation','P','Separation of axons away from a bundle of axons known as a fascicle.','2013-10-27','NSRP'),(5993,7415,'defasciculation of motor neuron axon','P','Separation of a motor axon away from a bundle of axons known as a fascicle.','2013-10-27','NSRP'),(5994,7416,'synapse assembly','P','The aggregation, arrangement and bonding together of a set of components to form a synapse.','2013-10-27','NSRP'),(5995,7417,'central nervous system development','P','The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.','2013-10-27','NSRP'),(5996,7418,'ventral midline development','P','The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate.','2013-10-27','NSRP'),(5997,7419,'ventral cord development','P','The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.','2013-10-27','NSRP'),(5998,7420,'brain development','P','The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).','2013-10-27','NSRP'),(5999,7421,'stomatogastric nervous system development','P','The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6000,7422,'peripheral nervous system development','P','The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.','2013-10-27','NSRP'),(6001,7423,'sensory organ development','P','The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6002,7424,'open tracheal system development','P','The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6003,7425,'epithelial cell fate determination, open tracheal system','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6004,7426,'tracheal outgrowth, open tracheal system','P','The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6005,7427,'epithelial cell migration, open tracheal system','P','The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6006,7428,'primary branching, open tracheal system','P','Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6007,7429,'secondary branching, open tracheal system','P','Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6008,7430,'terminal branching, open tracheal system','P','Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6009,7431,'salivary gland development','P','The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.','2013-10-27','NSRP'),(6010,7432,'salivary gland boundary specification','P','Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland.','2013-10-27','NSRP'),(6011,7433,'larval salivary gland boundary specification','P','Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland.','2013-10-27','NSRP'),(6012,7434,'adult salivary gland boundary specification','P','Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland.','2013-10-27','NSRP'),(6013,7435,'salivary gland morphogenesis','P','The process in which the anatomical structures of the salivary gland are generated and organized.','2013-10-27','NSRP'),(6014,7436,'larval salivary gland morphogenesis','P','The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized.','2013-10-27','NSRP'),(6015,7437,'adult salivary gland morphogenesis','P','The process in which the anatomical structures of the adult salivary gland are generated and organized.','2013-10-27','NSRP'),(6016,7438,'oenocyte development','P','The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments.','2013-10-27','NSRP'),(6017,7439,'ectodermal digestive tract development','P','The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm.','2013-10-27','NSRP'),(6018,7440,'foregut morphogenesis','P','The process in which the anatomical structures of the foregut are generated and organized.','2013-10-27','NSRP'),(6019,7441,'anterior midgut (ectodermal) morphogenesis','P','The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized.','2013-10-27','NSRP'),(6020,7442,'hindgut morphogenesis','P','The process in which the anatomical structures of the hindgut are generated and organized.','2013-10-27','NSRP'),(6021,7443,'Malpighian tubule morphogenesis','P','The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.','2013-10-27','NSRP'),(6022,7444,'imaginal disc development','P','The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.).','2013-10-27','NSRP'),(6023,7445,'determination of imaginal disc primordium','P','Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment.','2013-10-27','NSRP'),(6024,7446,'imaginal disc growth','P','The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form.','2013-10-27','NSRP'),(6025,7447,'imaginal disc pattern formation','P','The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form.','2013-10-27','NSRP'),(6026,7448,'anterior/posterior pattern specification, imaginal disc','P','The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form.','2013-10-27','NSRP'),(6027,7449,'proximal/distal pattern formation, imaginal disc','P','The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed.','2013-10-27','NSRP'),(6028,7450,'dorsal/ventral pattern formation, imaginal disc','P','The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed.','2013-10-27','NSRP'),(6029,7451,'dorsal/ventral lineage restriction, imaginal disc','P','Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment.','2013-10-27','NSRP'),(6030,7453,'clypeo-labral disc morphogenesis','P','The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus.','2013-10-27','NSRP'),(6031,7454,'labial disc morphogenesis','P','The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis.','2013-10-27','NSRP'),(6032,7455,'eye-antennal disc morphogenesis','P','The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps.','2013-10-27','NSRP'),(6033,7458,'progression of morphogenetic furrow involved in compound eye morphogenesis','P','The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc.','2013-10-27','NSRP'),(6034,7460,'R8 cell fate commitment','P','The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium.','2013-10-27','NSRP'),(6035,7462,'R1/R6 cell fate commitment','P','The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres.','2013-10-27','NSRP'),(6036,7463,'R2/R5 cell fate commitment','P','The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres.','2013-10-27','NSRP'),(6037,7464,'R3/R4 cell fate commitment','P','The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres.','2013-10-27','NSRP'),(6038,7465,'R7 cell fate commitment','P','The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium.','2013-10-27','NSRP'),(6039,7468,'regulation of rhodopsin gene expression','P','Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation.','2013-10-27','NSRP'),(6040,7469,'antennal development','P','The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli.','2013-10-27','NSRP'),(6041,7470,'prothoracic disc morphogenesis','P','The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle.','2013-10-27','NSRP'),(6042,7471,'prothoracic morphogenesis','P','OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized.','2013-10-27','NSRP'),(6043,7472,'wing disc morphogenesis','P','The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura.','2013-10-27','NSRP'),(6044,7473,'wing disc proximal/distal pattern formation','P','The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing.','2013-10-27','NSRP'),(6045,7474,'imaginal disc-derived wing vein specification','P','The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.','2013-10-27','NSRP'),(6046,7475,'apposition of dorsal and ventral imaginal disc-derived wing surfaces','P','The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing.','2013-10-27','NSRP'),(6047,7476,'imaginal disc-derived wing morphogenesis','P','The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.','2013-10-27','NSRP'),(6048,7477,'notum development','P','The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6049,7478,'leg disc morphogenesis','P','The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura.','2013-10-27','NSRP'),(6050,7479,'leg disc proximal/distal pattern formation','P','The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg.','2013-10-27','NSRP'),(6051,7480,'imaginal disc-derived leg morphogenesis','P','The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6052,7481,'haltere disc morphogenesis','P','The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum.','2013-10-27','NSRP'),(6053,7482,'haltere development','P','The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped \'balancers\' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings.','2013-10-27','NSRP'),(6054,7483,'genital disc morphogenesis','P','The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut.','2013-10-27','NSRP'),(6055,7484,'imaginal disc-derived genitalia development','P','The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6056,7485,'imaginal disc-derived male genitalia development','P','The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6057,7486,'imaginal disc-derived female genitalia development','P','The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6058,7487,'analia development','P','The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster.','2013-10-27','NSRP'),(6059,7488,'histoblast morphogenesis','P','The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen.','2013-10-27','NSRP'),(6060,7489,'maintenance of imaginal histoblast diploidy','P','The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells.','2013-10-27','NSRP'),(6061,7490,'tergite morphogenesis','P','The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment.','2013-10-27','NSRP'),(6062,7491,'sternite morphogenesis','P','The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment.','2013-10-27','NSRP'),(6063,7492,'endoderm development','P','The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.','2013-10-27','NSRP'),(6064,7493,'endodermal cell fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(6065,7494,'midgut development','P','The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.','2013-10-27','NSRP'),(6066,7495,'visceral mesoderm-endoderm interaction involved in midgut development','P','The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut.','2013-10-27','NSRP'),(6067,7496,'anterior midgut development','P','The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6068,7497,'posterior midgut development','P','The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6069,7498,'mesoderm development','P','The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue.','2013-10-27','NSRP'),(6070,7499,'ectoderm and mesoderm interaction','P','A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm.','2013-10-27','NSRP'),(6071,7500,'mesodermal cell fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(6072,7501,'mesodermal cell fate specification','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(6073,7502,'digestive tract mesoderm development','P','The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism.','2013-10-27','NSRP'),(6074,7503,'fat body development','P','The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism.','2013-10-27','NSRP'),(6075,7504,'larval fat body development','P','The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life.','2013-10-27','NSRP'),(6076,7505,'adult fat body development','P','The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body.','2013-10-27','NSRP'),(6077,7506,'gonadal mesoderm development','P','The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism.','2013-10-27','NSRP'),(6078,7507,'heart development','P','The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.','2013-10-27','NSRP'),(6079,7508,'larval heart development','P','The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper.','2013-10-27','NSRP'),(6080,7509,'mesoderm migration involved in gastrulation','P','The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism.','2013-10-27','NSRP'),(6081,7510,'cardioblast cell fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(6082,7512,'adult heart development','P','The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6083,7513,'pericardial cell differentiation','P','The process in which a relatively unspecialized mesodermal cell acquires the specialized features of a pericardial cell. In insects, pericardial cells are loosely arranged non-myogenic cells that flank the cardioblasts and probably act in the filtration of hemolymph.','2012-03-14','NSRP'),(6084,7514,'garland cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of a garland cell, a small group of nephrocytes which take up waste materials from the hemolymph by endocytosis.','2012-03-14','NSRP'),(6085,7515,'lymph gland development','P','OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system.','2013-10-27','NSRP'),(6086,7516,'hemocyte development','P','The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen.','2013-10-27','NSRP'),(6087,7517,'muscle organ development','P','The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.','2013-10-27','NSRP'),(6088,7518,'myoblast fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.','2013-10-27','NSRP'),(6089,7519,'skeletal muscle tissue development','P','The developmental sequence of events leading to the formation of adult muscle that occurs in the anima. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.','2013-10-27','NSRP'),(6090,7520,'myoblast fusion','P','A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.','2013-10-27','NSRP'),(6091,7521,'muscle cell fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(6092,7522,'visceral muscle development','P','The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6093,7523,'larval visceral muscle development','P','The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6094,7524,'adult visceral muscle development','P','The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6095,7525,'somatic muscle development','P','The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.','2013-10-27','NSRP'),(6096,7526,'larval somatic muscle development','P','The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6097,7527,'adult somatic muscle development','P','The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6098,7528,'neuromuscular junction development','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.','2013-10-27','NSRP'),(6099,7529,'establishment of synaptic specificity at neuromuscular junction','P','The biological process in which a synapse between a motor neuron and a muscle is initially formed.','2013-10-27','NSRP'),(6100,7530,'sex determination','P','Any process that establishes and transmits the specification of sexual status of an individual organism.','2013-10-27','NSRP'),(6101,7531,'mating type determination','P','Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms.','2013-10-27','NSRP'),(6102,7532,'regulation of mating-type specific transcription, DNA-dependent','P','Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-dependent transcription.','2013-10-27','NSRP'),(6103,7533,'mating type switching','P','The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus.','2013-10-27','NSRP'),(6104,7534,'gene conversion at mating-type locus','P','The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged.','2013-10-27','NSRP'),(6105,7535,'donor selection','P','The process that determines which donor locus a cell uses, in preference to another, in mating type switching.','2013-10-27','NSRP'),(6106,7536,'activation of recombination (HML)','P','The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(6107,7537,'inactivation of recombination (HML)','P','The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(6108,7538,'primary sex determination','P','The sex determination process that results in the initial specification of sexual status of an individual organism.','2013-10-27','NSRP'),(6109,7539,'primary sex determination, soma','P','The transmission of information about sexual status from the initial, general, determination to signals specific to the soma.','2013-10-27','NSRP'),(6110,7540,'sex determination, establishment of X:A ratio','P','The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it.','2013-10-27','NSRP'),(6111,7541,'sex determination, primary response to X:A ratio','P','The developmental process in which an organism interprets its X to autosomal chromosomal complement.','2013-10-27','NSRP'),(6112,7542,'primary sex determination, germ-line','P','The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line.','2013-10-27','NSRP'),(6113,7543,'sex determination, somatic-gonadal interaction','P','The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism.','2013-10-27','NSRP'),(6114,7545,'processes downstream of sex determination signal','P','The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways.','2013-10-27','NSRP'),(6115,7546,'somatic processes downstream of sex determination signal','P','The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways.','2013-10-27','NSRP'),(6116,7547,'germ-line processes downstream of sex determination signal','P','The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways.','2013-10-27','NSRP'),(6117,7548,'sex differentiation','P','The establishment of the sex of an organism by physical differentiation.','2013-10-27','NSRP'),(6118,7549,'dosage compensation','P','Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes.','2013-10-27','NSRP'),(6119,7550,'establishment of dosage compensation','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6120,7551,'maintenance of dosage compensation','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6121,7552,'metamorphosis','P','A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal\'s form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6122,7553,'regulation of ecdysteroid metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females.','2013-10-27','NSRP'),(6123,7554,'regulation of ecdysteroid biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids.','2013-10-27','NSRP'),(6124,7555,'regulation of ecdysteroid secretion','P','Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell.','2013-10-27','NSRP'),(6125,7556,'regulation of juvenile hormone metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone.','2013-10-27','NSRP'),(6126,7557,'regulation of juvenile hormone biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone.','2013-10-27','NSRP'),(6127,7558,'regulation of juvenile hormone secretion','P','Any process that modulates the frequency, rate or extent of juvenile hormone secretion.','2013-10-27','NSRP'),(6128,7559,'histolysis','P','The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue.','2013-10-27','NSRP'),(6129,7560,'imaginal disc morphogenesis','P','The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form.','2013-10-27','NSRP'),(6130,7561,'imaginal disc eversion','P','The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis.','2013-10-27','NSRP'),(6131,7562,'eclosion','P','The emergence of an adult insect from a pupa case.','2013-10-27','NSRP'),(6132,7563,'regulation of eclosion','P','Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg.','2013-10-27','NSRP'),(6133,7564,'regulation of chitin-based cuticle tanning','P','Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning.','2013-10-27','NSRP'),(6134,7565,'female pregnancy','P','The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.','2013-10-27','NSRP'),(6135,7566,'embryo implantation','P','Attachment of the blastocyst to the uterine lining.','2013-10-27','NSRP'),(6136,7567,'parturition','P','The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.','2013-10-27','NSRP'),(6137,7568,'aging','P','A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death (GO:0016265) and may succeed developmental maturation (GO:0021700).','2013-10-27','NSRP'),(6138,7569,'cell aging','P','An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).','2013-10-27','NSRP'),(6139,7570,'age dependent accumulation of genetic damage','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6140,7571,'age-dependent general metabolic decline','P','A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis.','2013-10-27','NSRP'),(6141,7572,'age dependent decreased translational activity','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6142,7573,'age dependent increased protein content','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6143,7574,'cell aging (sensu Saccharomyces)','P','OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell.','2013-10-27','NSRP'),(6144,7575,'nucleolar size increase','P','OBSOLETE. The process of nucleolar expansion.','2013-10-27','NSRP'),(6145,7576,'nucleolar fragmentation','P','The cell aging process that results in the nucleolus breaking down into fragments.','2013-10-27','NSRP'),(6146,7577,'autophagic death (sensu Saccharomyces)','P','OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA.','2013-10-27','NSRP'),(6147,7578,'aging dependent sterility (sensu Saccharomyces)','P','OBSOLETE. A haploid\'s inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes.','2013-10-27','NSRP'),(6148,7579,'senescence factor accumulation','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6149,7580,'extrachromosomal circular DNA accumulation involved in cell aging','P','Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication.','2013-10-27','NSRP'),(6150,7581,'age-dependent yeast cell size increase','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6151,7583,'killer activity','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6152,7584,'response to nutrient','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.','2013-10-27','NSRP'),(6153,7585,'respiratory gaseous exchange','P','The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism\'s cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.','2013-10-27','NSRP'),(6154,7586,'digestion','P','The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.','2013-10-27','NSRP'),(6155,7588,'excretion','P','The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.','2013-10-27','NSRP'),(6156,7589,'body fluid secretion','P','The controlled release of a fluid by a cell or tissue in an animal.','2013-10-27','NSRP'),(6157,7590,'fat body metabolic process (sensu Insecta)','P','OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557).','2013-10-27','NSRP'),(6158,7591,'molting cycle, chitin-based cuticle','P','The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6159,7592,'protein-based cuticle development','P','OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(6160,7593,'chitin-based cuticle sclerotization','P','The process of hardening of a chitin-based cuticle.','2013-10-27','NSRP'),(6161,7594,'puparial adhesion','P','The adhesion of the puparia of Diptera to their substrate; normally effected by a \'glue\' secreted by the larval salivary gland and expectorated at the time of pupariation.','2013-10-27','NSRP'),(6162,7595,'lactation','P','The secretion of milk by the mammary gland.','2013-10-27','NSRP'),(6163,7596,'blood coagulation','P','The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.','2013-10-27','NSRP'),(6164,7597,'blood coagulation, intrinsic pathway','P','A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X.','2013-10-27','NSRP'),(6165,7598,'blood coagulation, extrinsic pathway','P','A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X.','2013-10-27','NSRP'),(6166,7599,'hemostasis','P','The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.','2013-10-27','NSRP'),(6167,7600,'sensory perception','P','The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.','2013-10-27','NSRP'),(6168,7601,'visual perception','P','The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.','2013-10-27','NSRP'),(6169,7602,'phototransduction','P','The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.','2013-10-27','NSRP'),(6170,7603,'phototransduction, visible light','P','The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.','2013-10-27','NSRP'),(6171,7604,'phototransduction, UV','P','The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.','2013-10-27','NSRP'),(6172,7605,'sensory perception of sound','P','The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.','2013-10-27','NSRP'),(6173,7606,'sensory perception of chemical stimulus','P','The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.','2013-10-27','NSRP'),(6174,7607,'taste perception','P','OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal.','2013-10-27','NSRP'),(6175,7608,'sensory perception of smell','P','The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism\'s ambient medium by chemoreceptors. This is a neurological process.','2013-10-27','NSRP'),(6176,7610,'behavior','P','The internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.','2013-10-27','NSRP'),(6177,7611,'learning or memory','P','The acquisition and processing of information and/or the storage and retrieval of this information over time.','2013-10-27','NSRP'),(6178,7612,'learning','P','Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.','2013-10-27','NSRP'),(6179,7613,'memory','P','The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).','2013-10-27','NSRP'),(6180,7614,'short-term memory','P','The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.','2013-10-27','NSRP'),(6181,7615,'anesthesia-resistant memory','P','The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis.','2013-10-27','NSRP'),(6182,7616,'long-term memory','P','The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.','2013-10-27','NSRP'),(6183,7617,'mating behavior','P','The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.','2013-10-27','NSRP'),(6184,7618,'mating','P','The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.','2013-10-27','NSRP'),(6185,7619,'courtship behavior','P','The behavioral interactions between organisms for the purpose of attracting sexual partners.','2013-10-27','NSRP'),(6186,7620,'copulation','P','The act of sexual union between male and female, involving the transfer of sperm.','2013-10-27','NSRP'),(6187,7621,'negative regulation of female receptivity','P','Any process that stops, prevents or reduces the receptiveness of a female to male advances.','2013-10-27','NSRP'),(6188,7622,'rhythmic behavior','P','The specific behavior of an organism that recur with measured regularity.','2013-10-27','NSRP'),(6189,7623,'circadian rhythm','P','Any biological process in an organism that recurs with a regularity of approximately 24 hours.','2013-10-27','NSRP'),(6190,7624,'ultradian rhythm','P','The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours.','2013-10-27','NSRP'),(6191,7625,'grooming behavior','P','The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites.','2013-10-27','NSRP'),(6192,7626,'locomotory behavior','P','The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism\'s internal state and external conditions.','2013-10-27','NSRP'),(6193,7627,'larval behavior (sensu Insecta)','P','OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects.','2013-10-27','NSRP'),(6194,7628,'adult walking behavior','P','The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.','2013-10-27','NSRP'),(6195,7629,'flight behavior','P','The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air.','2013-10-27','NSRP'),(6196,7630,'jump response','P','The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus.','2013-10-27','NSRP'),(6197,7631,'feeding behavior','P','Behavior associated with the intake of food.','2013-10-27','NSRP'),(6198,7632,'visual behavior','P','The behavior of an organism in response to a visual stimulus.','2013-10-27','NSRP'),(6199,7633,'pattern orientation','P','The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes.','2013-10-27','NSRP'),(6200,7634,'optokinetic behavior','P','The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus.','2013-10-27','NSRP'),(6201,7635,'chemosensory behavior','P','Behavior that is dependent upon the sensation of chemicals.','2013-10-27','NSRP'),(6202,7636,'chemosensory jump behavior','P','The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance.','2013-10-27','NSRP'),(6203,7637,'proboscis extension reflex','P','The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus.','2013-10-27','NSRP'),(6204,7638,'mechanosensory behavior','P','Behavior that is dependent upon the sensation of a mechanical stimulus.','2013-10-27','NSRP'),(6205,7639,'homeostasis of number of meristem cells','P','Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem.','2013-10-27','NSRP'),(6206,8001,'fibrinogen','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6207,8002,'lamina lucida','C','The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina.','2013-10-27','NSRP'),(6208,8003,'lamina densa','C','The electron-dense layer of the basal lamina; lies just below the lamina lucida.','2013-10-27','NSRP'),(6209,8004,'lamina reticularis','C','A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue.','2013-10-27','NSRP'),(6210,8008,'membrane attack complex protein beta2 chain','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6211,8009,'chemokine activity','F','The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation.','2013-10-27','NSRP'),(6212,8010,'structural constituent of chitin-based larval cuticle','F','The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6213,8011,'structural constituent of pupal chitin-based cuticle','F','The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6214,8012,'structural constituent of adult chitin-based cuticle','F','The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6215,8013,'beta-catenin binding','F','Interacting selectively and non-covalently with the beta subunit of the catenin complex.','2013-10-27','NSRP'),(6216,8014,'calcium-dependent cell adhesion molecule activity','F','OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions.','2013-10-27','NSRP'),(6217,8015,'blood circulation','P','The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.','2013-10-27','NSRP'),(6218,8016,'regulation of heart contraction','P','Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.','2013-10-27','NSRP'),(6219,8017,'microtubule binding','F','Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.','2013-10-27','NSRP'),(6220,8018,'structural protein of chorion (sensu Drosophila)','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6221,8019,'macrophage receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6222,8020,'G-protein coupled photoreceptor activity','F','Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(6223,8021,'synaptic vesicle','C','A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the \'active zone\' of the presynaptic plasma membrane.','2013-10-27','NSRP'),(6224,8022,'protein C-terminus binding','F','Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.','2013-10-27','NSRP'),(6225,8023,'transcription elongation factor complex','C','Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.','2013-10-27','NSRP'),(6226,8024,'positive transcription elongation factor complex b','C','A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains cyclin T and a cyclin-dependent protein kinase catalytic subunit.','2013-10-27','NSRP'),(6227,8025,'diazepam binding inhibitor activity','F','OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters.','2013-10-27','NSRP'),(6228,8026,'ATP-dependent helicase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix.','2013-10-27','NSRP'),(6229,8028,'monocarboxylic acid transmembrane transporter activity','F','Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.','2013-10-27','NSRP'),(6230,8029,'pentraxin receptor activity','F','Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(6231,8030,'neuronal pentraxin receptor activity','F','Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(6232,8031,'eclosion hormone activity','F','The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis.','2013-10-27','NSRP'),(6233,8033,'tRNA processing','P','The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.','2013-10-27','NSRP'),(6234,8034,'lipoprotein binding','F','OBSOLETE. Interacting selectively and non-covalently with any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.','2013-10-27','NSRP'),(6235,8035,'high-density lipoprotein particle binding','F','Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.','2013-10-27','NSRP'),(6236,8036,'diuretic hormone receptor activity','F','Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity.','2013-10-27','NSRP'),(6237,8037,'cell recognition','P','The process in which a cell in a multicellular organism interprets its surroundings.','2013-10-27','NSRP'),(6238,8038,'neuron recognition','P','The process in which a neuronal cell in a multicellular organism interprets its surroundings.','2013-10-27','NSRP'),(6239,8039,'synaptic target recognition','P','The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses.','2013-10-27','NSRP'),(6240,8041,'storage protein of fat body (sensu Insecta)','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6241,8042,'iron-sulfur electron transfer carrier','F','OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system.','2013-10-27','NSRP'),(6242,8043,'intracellular ferritin complex','C','A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains.','2013-10-27','NSRP'),(6243,8044,'adult behavior (sensu Insecta)','P','OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects.','2013-10-27','NSRP'),(6244,8045,'motor neuron axon guidance','P','The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(6245,8046,'axon guidance receptor activity','F','Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.','2013-10-27','NSRP'),(6246,8047,'enzyme activator activity','F','Increases the activity of an enzyme.','2013-10-27','NSRP'),(6247,8048,'calcium sensitive guanylate cyclase activator activity','F','Increases the activity of guanylate cyclase in response to a change in calcium ion concentration.','2013-10-27','NSRP'),(6248,8049,'male courtship behavior','P','The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6249,8050,'female courtship behavior','P','The behavior of a female, for the purpose of attracting a sexual partner.','2013-10-27','NSRP'),(6250,8051,'farnesyl-diphosphate farnesyl transferase complex','C','OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity.','2013-10-27','NSRP'),(6251,8052,'sensory organ boundary specification','P','The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained.','2013-10-27','NSRP'),(6252,8053,'mitochondrial fusion','P','Merging of two or more mitochondria within a cell to form a single compartment.','2013-10-27','NSRP'),(6253,8054,'cyclin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions.','2013-10-27','NSRP'),(6254,8055,'ocellus pigment biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates.','2013-10-27','NSRP'),(6255,8056,'ocellus development','P','The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects.','2013-10-27','NSRP'),(6256,8057,'eye pigment granule organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye.','2013-10-27','NSRP'),(6257,8058,'ocellus pigment granule organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus.','2013-10-27','NSRP'),(6258,8060,'ARF GTPase activator activity','F','Increases the rate of GTP hydrolysis by the GTPase ARF.','2013-10-27','NSRP'),(6259,8061,'chitin binding','F','Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.','2013-10-27','NSRP'),(6260,8062,'eclosion rhythm','P','The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn.','2013-10-27','NSRP'),(6261,8063,'Toll signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(6262,8064,'regulation of actin polymerization or depolymerization','P','Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.','2013-10-27','NSRP'),(6263,8065,'establishment of blood-nerve barrier','P','The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier.','2013-10-27','NSRP'),(6264,8066,'glutamate receptor activity','F','Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(6265,8067,'metabotropic glutamate, GABA-B-like receptor activity','F','OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor.','2013-10-27','NSRP'),(6266,8068,'extracellular-glutamate-gated chloride channel activity','F','Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(6267,8069,'dorsal/ventral axis specification, ovarian follicular epithelium','P','Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6268,8070,'maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded','P','Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line.','2013-10-27','NSRP'),(6269,8071,'maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded','P','Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6270,8073,'ornithine decarboxylase inhibitor activity','F','The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase.','2013-10-27','NSRP'),(6271,8074,'guanylate cyclase complex, soluble','C','Complex that possesses guanylate cyclase activity and is not bound to a membrane.','2013-10-27','NSRP'),(6272,8075,'receptor guanylate cyclase activity','F','OBSOLETE. Catalysis of the reaction: GTP = 3\',5\'-cyclic GMP + diphosphate.','2013-10-27','NSRP'),(6273,8076,'voltage-gated potassium channel complex','C','A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.','2013-10-27','NSRP'),(6274,8077,'Hsp70/Hsp90 organizing protein activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6275,8078,'mesodermal cell migration','P','The orderly movement of mesodermal cells from one site to another.','2013-10-27','NSRP'),(6276,8079,'translation termination factor activity','F','Functions in the termination of translation.','2013-10-27','NSRP'),(6277,8080,'N-acetyltransferase activity','F','Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.','2013-10-27','NSRP'),(6278,8081,'phosphoric diester hydrolase activity','F','Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.','2013-10-27','NSRP'),(6279,8083,'growth factor activity','F','The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.','2013-10-27','NSRP'),(6280,8084,'imaginal disc growth factor receptor binding','F','Interacting selectively and non-covalently with an imaginal disc growth factor receptor.','2013-10-27','NSRP'),(6281,8085,'phototransduction, visible light, light adaptation','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6282,8086,'light-activated voltage-gated calcium channel activity','F','Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(6283,8087,'light-activated voltage-gated calcium channel complex','C','A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus.','2013-10-27','NSRP'),(6284,8088,'axon cargo transport','P','The directed movement of organelles or molecules along microtubules in nerve cell axons.','2013-10-27','NSRP'),(6285,8089,'anterograde axon cargo transport','P','The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.','2013-10-27','NSRP'),(6286,8090,'retrograde axon cargo transport','P','The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.','2013-10-27','NSRP'),(6287,8091,'spectrin','C','Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins.','2013-10-27','NSRP'),(6288,8092,'cytoskeletal protein binding','F','Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).','2013-10-27','NSRP'),(6289,8093,'cytoskeletal adaptor activity','F','The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way.','2013-10-27','NSRP'),(6290,8094,'DNA-dependent ATPase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction.','2013-10-27','NSRP'),(6291,8096,'juvenile hormone epoxide hydrolase activity','F','Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol.','2013-10-27','NSRP'),(6292,8097,'5S rRNA binding','F','Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome.','2013-10-27','NSRP'),(6293,8098,'5S rRNA primary transcript binding','F','Interacting selectively and non-covalently with the unprocessed 5S ribosomal RNA transcript.','2013-10-27','NSRP'),(6294,8100,'lipophorin','F','OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects.','2013-10-27','NSRP'),(6295,8101,'decapentaplegic signaling pathway','P','A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(6296,8103,'oocyte microtubule cytoskeleton polarization','P','Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6297,8104,'protein localization','P','Any process in which a protein is transported to, or maintained in, a specific location.','2013-10-27','NSRP'),(6298,8105,'asymmetric protein localization','P','Any process in which a protein is transported to, or maintained in, a specific location such that it is distributed asymmetrically.','2013-10-27','NSRP'),(6299,8106,'alcohol dehydrogenase (NADP+) activity','F','Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+.','2013-10-27','NSRP'),(6300,8107,'galactoside 2-alpha-L-fucosyltransferase activity','F','Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R.','2013-10-27','NSRP'),(6301,8108,'UDP-glucose:hexose-1-phosphate uridylyltransferase activity','F','Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose.','2013-10-27','NSRP'),(6302,8109,'N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.','2013-10-27','NSRP'),(6303,8110,'L-histidine:2-oxoglutarate aminotransferase activity','F','Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate.','2013-10-27','NSRP'),(6304,8111,'alpha-methylacyl-CoA racemase activity','F','Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.','2013-10-27','NSRP'),(6305,8112,'nicotinamide N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(6306,8113,'peptide-methionine (S)-S-oxide reductase activity','F','Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin.','2013-10-27','NSRP'),(6307,8114,'phosphogluconate 2-dehydrogenase activity','F','Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH.','2013-10-27','NSRP'),(6308,8115,'sarcosine oxidase activity','F','Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2).','2013-10-27','NSRP'),(6309,8116,'prostaglandin-I synthase activity','F','Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).','2013-10-27','NSRP'),(6310,8117,'sphinganine-1-phosphate aldolase activity','F','Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde.','2013-10-27','NSRP'),(6311,8118,'N-acetyllactosaminide alpha-2,3-sialyltransferase activity','F','Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein.','2013-10-27','NSRP'),(6312,8119,'thiopurine S-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.','2013-10-27','NSRP'),(6313,8120,'ceramide glucosyltransferase activity','F','Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.','2013-10-27','NSRP'),(6314,8121,'ubiquinol-cytochrome-c reductase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.','2013-10-27','NSRP'),(6315,8123,'cholesterol 7-alpha-monooxygenase activity','F','Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O.','2013-10-27','NSRP'),(6316,8124,'4-alpha-hydroxytetrahydrobiopterin dehydratase activity','F','Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.','2013-10-27','NSRP'),(6317,8125,'pancreatic elastase I activity','F','OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa.','2013-10-27','NSRP'),(6318,8126,'acetylesterase activity','F','Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate.','2013-10-27','NSRP'),(6319,8127,'quercetin 2,3-dioxygenase activity','F','Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO.','2013-10-27','NSRP'),(6320,8129,'actinidain activity','F','OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1\'.','2013-10-27','NSRP'),(6321,8130,'neutrophil collagenase activity','F','OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.','2013-10-27','NSRP'),(6322,8131,'primary amine oxidase activity','F','Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide.','2013-10-27','NSRP'),(6323,8132,'pancreatic elastase activity','F','OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin.','2013-10-27','NSRP'),(6324,8133,'collagenase activity','F','OBSOLETE. Was not defined before being made obsolete.','2013-10-27','NSRP'),(6325,8134,'transcription factor binding','F','Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription.','2013-10-27','NSRP'),(6326,8135,'translation factor activity, nucleic acid binding','F','Functions during translation by interacting selectively and non-covalently with nucleic acids during polypeptide synthesis at the ribosome.','2013-10-27','NSRP'),(6327,8137,'NADH dehydrogenase (ubiquinone) activity','F','Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol.','2013-10-27','NSRP'),(6328,8138,'protein tyrosine/serine/threonine phosphatase activity','F','Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.','2013-10-27','NSRP'),(6329,8139,'nuclear localization sequence binding','F','Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus.','2013-10-27','NSRP'),(6330,8140,'cAMP response element binding protein binding','F','Interacting selectively and non-covalently with the cAMP response element binding protein.','2013-10-27','NSRP'),(6331,8141,'puparial glue (sensu Diptera)','F','OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147).','2013-10-27','NSRP'),(6332,8142,'oxysterol binding','F','Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol.','2013-10-27','NSRP'),(6333,8143,'poly(A) RNA binding','F','Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3\' end of eukaryotic mRNA.','2013-10-27','NSRP'),(6334,8144,'drug binding','F','Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.','2013-10-27','NSRP'),(6335,8145,'phenylalkylamine binding','F','Interacting selectively and non-covalently with phenylalkylamine or any of its derivatives.','2013-10-27','NSRP'),(6336,8146,'sulfotransferase activity','F','Catalysis of the transfer of a sulfate group from 3\'-phosphoadenosine 5\'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3\'-phosphoadenosine 5\'-phosphate.','2013-10-27','NSRP'),(6337,8147,'structural constituent of bone','F','The action of a molecule that contributes to the structural integrity of bone.','2013-10-27','NSRP'),(6338,8148,'negative transcription elongation factor activity','F','OBSOLETE. Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation.','2013-10-27','NSRP'),(6339,8149,'para-aminobenzoic acid (PABA) synthase','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6340,8150,'biological_process','P','Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end.','2013-10-27','NSRP'),(6341,8152,'metabolic process','P','The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation.','2013-10-27','NSRP'),(6342,8153,'para-aminobenzoic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins.','2013-10-27','NSRP'),(6343,8154,'actin polymerization or depolymerization','P','Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament.','2013-10-27','NSRP'),(6344,8155,'larval behavior (sensu Drosophila)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6345,8156,'negative regulation of DNA replication','P','Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.','2013-10-27','NSRP'),(6346,8157,'protein phosphatase 1 binding','F','Interacting selectively and non-covalently with the enzyme protein phosphatase 1.','2013-10-27','NSRP'),(6347,8158,'hedgehog receptor activity','F','Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.','2013-10-27','NSRP'),(6348,8159,'positive transcription elongation factor activity','F','OBSOLETE. Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation.','2013-10-27','NSRP'),(6349,8160,'protein tyrosine phosphatase activator activity','F','Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein.','2013-10-27','NSRP'),(6350,8161,'carbamate resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6351,8162,'cyclodiene resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6352,8163,'DDT resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6353,8164,'organophosphorus resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6354,8165,'pyrethroid resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6355,8166,'viral replication','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6356,8167,'sigma virus replication','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6357,8168,'methyltransferase activity','F','Catalysis of the transfer of a methyl group to an acceptor molecule.','2013-10-27','NSRP'),(6358,8169,'C-methyltransferase activity','F','Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule.','2013-10-27','NSRP'),(6359,8170,'N-methyltransferase activity','F','Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.','2013-10-27','NSRP'),(6360,8171,'O-methyltransferase activity','F','Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.','2013-10-27','NSRP'),(6361,8172,'S-methyltransferase activity','F','Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.','2013-10-27','NSRP'),(6362,8173,'RNA methyltransferase activity','F','Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.','2013-10-27','NSRP'),(6363,8174,'mRNA methyltransferase activity','F','Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.','2013-10-27','NSRP'),(6364,8175,'tRNA methyltransferase activity','F','Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule.','2013-10-27','NSRP'),(6365,8176,'tRNA (guanine-N7-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine.','2013-10-27','NSRP'),(6366,8177,'succinate dehydrogenase (ubiquinone) activity','F','Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol.','2013-10-27','NSRP'),(6367,8179,'adenylate cyclase binding','F','Interacting selectively and non-covalently with the enzyme adenylate cyclase.','2013-10-27','NSRP'),(6368,8180,'COP9 signalosome','C','A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.','2013-10-27','NSRP'),(6369,8181,'tumor suppressor','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6370,8184,'glycogen phosphorylase activity','F','Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.','2013-10-27','NSRP'),(6371,8186,'RNA-dependent ATPase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction.','2013-10-27','NSRP'),(6372,8187,'poly-pyrimidine tract binding','F','Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule.','2013-10-27','NSRP'),(6373,8188,'neuropeptide receptor activity','F','Combining with a neuropeptide to initiate a change in cell activity.','2013-10-27','NSRP'),(6374,8189,'apoptosis inhibitor activity','F','OBSOLETE. The function held by products which directly block any step in the process of apoptosis.','2013-10-27','NSRP'),(6375,8190,'eukaryotic initiation factor 4E binding','F','Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation.','2013-10-27','NSRP'),(6376,8191,'metalloendopeptidase inhibitor activity','F','Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.','2013-10-27','NSRP'),(6377,8192,'RNA guanylyltransferase activity','F','Catalysis of the posttranscriptional addition of a guanyl residue to the 5\' end of an RNA molecule.','2013-10-27','NSRP'),(6378,8193,'tRNA guanylyltransferase activity','F','Catalysis of the posttranscriptional addition of a guanyl residue to the 5\' end of a tRNA molecule; observed for His tRNAs.','2013-10-27','NSRP'),(6379,8194,'UDP-glycosyltransferase activity','F','Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule.','2013-10-27','NSRP'),(6380,8195,'phosphatidate phosphatase activity','F','Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.','2013-10-27','NSRP'),(6381,8196,'vitellogenin receptor activity','F','Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis.','2013-10-27','NSRP'),(6382,8197,'yolk protein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6383,8198,'ferrous iron binding','F','Interacting selectively and non-covalently with ferrous iron, Fe(II).','2013-10-27','NSRP'),(6384,8199,'ferric iron binding','F','Interacting selectively and non-covalently with ferric iron, Fe(III).','2013-10-27','NSRP'),(6385,8200,'ion channel inhibitor activity','F','Stops, prevents, or reduces the activity of an ion channel.','2013-10-27','NSRP'),(6386,8201,'heparin binding','F','Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.','2013-10-27','NSRP'),(6387,8202,'steroid metabolic process','P','The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.','2013-10-27','NSRP'),(6388,8203,'cholesterol metabolic process','P','The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.','2013-10-27','NSRP'),(6389,8204,'ergosterol metabolic process','P','The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light.','2013-10-27','NSRP'),(6390,8205,'ecdysone metabolic process','P','The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development.','2013-10-27','NSRP'),(6391,8206,'bile acid metabolic process','P','The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.','2013-10-27','NSRP'),(6392,8207,'C21-steroid hormone metabolic process','P','The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.','2013-10-27','NSRP'),(6393,8208,'C21-steroid hormone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.','2013-10-27','NSRP'),(6394,8209,'androgen metabolic process','P','The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics.','2013-10-27','NSRP'),(6395,8210,'estrogen metabolic process','P','The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.','2013-10-27','NSRP'),(6396,8211,'glucocorticoid metabolic process','P','The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.','2013-10-27','NSRP'),(6397,8212,'mineralocorticoid metabolic process','P','The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance.','2013-10-27','NSRP'),(6398,8213,'protein alkylation','P','The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom.','2013-10-27','NSRP'),(6399,8214,'protein dealkylation','P','The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom.','2013-10-27','NSRP'),(6400,8215,'spermine metabolic process','P','The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication.','2013-10-27','NSRP'),(6401,8216,'spermidine metabolic process','P','The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane.','2013-10-27','NSRP'),(6402,8217,'regulation of blood pressure','P','Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.','2013-10-27','NSRP'),(6403,8218,'bioluminescence','P','The production of light by certain enzyme-catalyzed reactions in cells.','2013-10-27','NSRP'),(6404,8219,'cell death','P','Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \"apoptotic bodies\"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.','2013-10-27','NSRP'),(6405,8220,'necrosis','P','OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism.','2013-10-27','NSRP'),(6406,8222,'tumor antigen','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6407,8224,'Gram-positive antibacterial peptide activity','F','OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells.','2013-10-27','NSRP'),(6408,8225,'Gram-negative antibacterial peptide activity','F','OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells.','2013-10-27','NSRP'),(6409,8226,'tyramine receptor activity','F','Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine.','2013-10-27','NSRP'),(6410,8227,'G-protein coupled amine receptor activity','F','Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(6411,8228,'opsonization','P','The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody.','2013-10-27','NSRP'),(6412,8229,'opsonin activity','F','OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis.','2013-10-27','NSRP'),(6413,8230,'ecdysone receptor holocomplex','C','A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes.','2013-10-27','NSRP'),(6414,8231,'repressor ecdysone receptor complex','C','A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes.','2013-10-27','NSRP'),(6415,8232,'activator ecdysone receptor complex','C','A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes.','2013-10-27','NSRP'),(6416,8233,'peptidase activity','F','Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.','2013-10-27','NSRP'),(6417,8234,'cysteine-type peptidase activity','F','Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.','2013-10-27','NSRP'),(6418,8235,'metalloexopeptidase activity','F','Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.','2013-10-27','NSRP'),(6419,8236,'serine-type peptidase activity','F','Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).','2013-10-27','NSRP'),(6420,8237,'metallopeptidase activity','F','Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.','2013-10-27','NSRP'),(6421,8238,'exopeptidase activity','F','Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both.','2013-10-27','NSRP'),(6422,8239,'dipeptidyl-peptidase activity','F','Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain.','2013-10-27','NSRP'),(6423,8240,'tripeptidyl-peptidase activity','F','Catalysis of the release of an N-terminal tripeptide from a polypeptide.','2013-10-27','NSRP'),(6424,8241,'peptidyl-dipeptidase activity','F','Catalysis of the release of C-terminal dipeptides from a polypeptide chain.','2013-10-27','NSRP'),(6425,8242,'omega peptidase activity','F','Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups).','2013-10-27','NSRP'),(6426,8243,'plasminogen activator activity','F','OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin.','2013-10-27','NSRP'),(6427,8245,'lysosomal membrane hydrogen-transporting ATPase','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6428,8246,'electron transfer flavoprotein','F','OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system.','2013-10-27','NSRP'),(6429,8247,'1-alkyl-2-acetylglycerophosphocholine esterase complex','C','An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF).','2013-10-27','NSRP'),(6430,8248,'pre-mRNA splicing factor activity','F','OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA.','2013-10-27','NSRP'),(6431,8250,'oligosaccharyltransferase complex','C','A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected.','2013-10-27','NSRP'),(6432,8251,'tRNA-specific adenosine deaminase activity','F','Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule.','2013-10-27','NSRP'),(6433,8252,'nucleotidase activity','F','Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate.','2013-10-27','NSRP'),(6434,8253,'5\'-nucleotidase activity','F','Catalysis of the reaction: a 5\'-ribonucleotide + H2O = a ribonucleoside + phosphate.','2013-10-27','NSRP'),(6435,8254,'3\'-nucleotidase activity','F','Catalysis of the reaction: a 3\'-ribonucleotide + H2O = a ribonucleoside + phosphate.','2013-10-27','NSRP'),(6436,8255,'ecdysis-triggering hormone activity','F','The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system.','2013-10-27','NSRP'),(6437,8256,'protein histidine pros-kinase activity','F','Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine.','2013-10-27','NSRP'),(6438,8257,'protein histidine tele-kinase activity','F','Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine.','2013-10-27','NSRP'),(6439,8258,'head involution','P','Movement of the anterior ectoderm to the interior of the embryo.','2013-10-27','NSRP'),(6440,8259,'transforming growth factor beta ligand binding to type I receptor','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6441,8260,'3-oxoacid CoA-transferase activity','F','Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA.','2013-10-27','NSRP'),(6442,8261,'allatostatin receptor activity','F','Combining with allatostatin to initiate a change in cell activity.','2013-10-27','NSRP'),(6443,8262,'importin-alpha export receptor activity','F','Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm.','2013-10-27','NSRP'),(6444,8263,'pyrimidine-specific mismatch base pair DNA N-glycosylase activity','F','Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1\' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site.','2013-10-27','NSRP'),(6445,8265,'Mo-molybdopterin cofactor sulfurase activity','F','Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase.','2013-10-27','NSRP'),(6446,8266,'poly(U) RNA binding','F','Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule.','2013-10-27','NSRP'),(6447,8267,'poly-glutamine tract binding','F','Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein.','2013-10-27','NSRP'),(6448,8268,'receptor signaling protein tyrosine kinase signaling protein activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6449,8269,'JAK pathway signal transduction adaptor activity','F','The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way.','2013-10-27','NSRP'),(6450,8270,'zinc ion binding','F','Interacting selectively and non-covalently with zinc (Zn) ions.','2013-10-27','NSRP'),(6451,8271,'secondary active sulfate transmembrane transporter activity','F','Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.','2013-10-27','NSRP'),(6452,8272,'sulfate transport','P','The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(6453,8273,'calcium, potassium:sodium antiporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in).','2013-10-27','NSRP'),(6454,8274,'gamma-tubulin ring complex','C','A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule.','2013-10-27','NSRP'),(6455,8275,'gamma-tubulin small complex','C','A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex.','2013-10-27','NSRP'),(6456,8276,'protein methyltransferase activity','F','Catalysis of the transfer of a methyl group (CH3-) to a protein.','2013-10-27','NSRP'),(6457,8277,'regulation of G-protein coupled receptor protein signaling pathway','P','Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.','2013-10-27','NSRP'),(6458,8278,'cohesin complex','C','A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).','2013-10-27','NSRP'),(6459,8280,'cohesin core heterodimer','C','The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes.','2013-10-27','NSRP'),(6460,8281,'sulfonylurea receptor activity','F','Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(6461,8282,'ATP-sensitive potassium channel complex','C','A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.2 subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SUR1 subunit stimulates channel activity.','2013-10-27','NSRP'),(6462,8283,'cell proliferation','P','The multiplication or reproduction of cells, resulting in the expansion of a cell population.','2013-10-27','NSRP'),(6463,8284,'positive regulation of cell proliferation','P','Any process that activates or increases the rate or extent of cell proliferation.','2013-10-27','NSRP'),(6464,8285,'negative regulation of cell proliferation','P','Any process that stops, prevents or reduces the rate or extent of cell proliferation.','2013-10-27','NSRP'),(6465,8286,'insulin receptor signaling pathway','P','The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.','2013-10-27','NSRP'),(6466,8287,'protein serine/threonine phosphatase complex','C','A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein.','2013-10-27','NSRP'),(6467,8288,'boss receptor activity','F','Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.','2013-10-27','NSRP'),(6468,8289,'lipid binding','F','Interacting selectively and non-covalently with a lipid.','2013-10-27','NSRP'),(6469,8290,'F-actin capping protein complex','C','A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments.','2013-10-27','NSRP'),(6470,8291,'acetylcholine metabolic process','P','The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.','2013-10-27','NSRP'),(6471,8292,'acetylcholine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.','2013-10-27','NSRP'),(6472,8293,'torso signaling pathway','P','A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(6473,8294,'calcium- and calmodulin-responsive adenylate cyclase activity','F','Catalysis of the reaction: ATP = 3\',5\'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin.','2013-10-27','NSRP'),(6474,8295,'spermidine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane.','2013-10-27','NSRP'),(6475,8296,'3\'-5\'-exodeoxyribonuclease activity','F','Catalysis of the sequential cleavage of mononucleotides from a free 3\' terminus of a DNA molecule.','2013-10-27','NSRP'),(6476,8297,'single-stranded DNA exodeoxyribonuclease activity','F','Catalysis of the sequential cleavage of mononucleotides from a free 5\' or 3\' terminus of a single-stranded DNA molecule.','2013-10-27','NSRP'),(6477,8298,'intracellular mRNA localization','P','Any process in which mRNA is transported to, or maintained in, a specific location within the cell.','2013-10-27','NSRP'),(6478,8299,'isoprenoid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.','2013-10-27','NSRP'),(6479,8300,'isoprenoid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.','2013-10-27','NSRP'),(6480,8301,'DNA binding, bending','F','The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.','2013-10-27','NSRP'),(6481,8302,'female germline ring canal formation, actin assembly','P','Recruitment and organization of actin filaments in female germline ring canals.','2013-10-27','NSRP'),(6482,8303,'caspase complex','C','A protein complex that is located in the cytosol and contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes.','2013-10-27','NSRP'),(6483,8304,'eukaryotic translation initiation factor 4 complex','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6484,8305,'integrin complex','C','A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.','2013-10-27','NSRP'),(6485,8306,'associative learning','P','Learning by associating a stimulus (the cause) with a particular outcome (the effect).','2013-10-27','NSRP'),(6486,8307,'structural constituent of muscle','F','The action of a molecule that contributes to the structural integrity of a muscle fiber.','2013-10-27','NSRP'),(6487,8308,'voltage-gated anion channel activity','F','Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(6488,8309,'double-stranded DNA exodeoxyribonuclease activity','F','Catalysis of the sequential cleavage of mononucleotides from a free 5\' or 3\' terminus of a double-stranded DNA molecule.','2013-10-27','NSRP'),(6489,8310,'single-stranded DNA 3\'-5\' exodeoxyribonuclease activity','F','Catalysis of the sequential cleavage of mononucleotides from a free 3\' terminus of a single-stranded DNA molecule.','2013-10-27','NSRP'),(6490,8311,'double-stranded DNA 3\'-5\' exodeoxyribonuclease activity','F','Catalysis of the sequential cleavage of mononucleotides from a free 3\' terminus of a double-stranded DNA molecule.','2013-10-27','NSRP'),(6491,8312,'7S RNA binding','F','Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP).','2013-10-27','NSRP'),(6492,8313,'gurken-activated receptor activity','F','Combining with the ligand Gurken to initiate a change in cell activity.','2013-10-27','NSRP'),(6493,8314,'gurken receptor signaling pathway','P','The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken.','2013-10-27','NSRP'),(6494,8315,'meiotic G2/MI transition','P','The cell cycle process in which a cell progresses from meiotic prophase to metaphase I.','2013-10-27','NSRP'),(6495,8316,'structural constituent of vitelline membrane','F','The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6496,8317,'gurken receptor binding','F','Interacting selectively and non-covalently with the gurken growth factor receptor.','2013-10-27','NSRP'),(6497,8318,'protein prenyltransferase activity','F','Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein.','2013-10-27','NSRP'),(6498,8319,'prenyl protein specific endopeptidase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6499,8320,'protein transmembrane transporter activity','F','Catalysis of the transfer of a protein from one side of a membrane to the other.','2013-10-27','NSRP'),(6500,8321,'Ral guanyl-nucleotide exchange factor activity','F','Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.','2013-10-27','NSRP'),(6501,8322,'Pro-X carboxypeptidase activity','F','OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid.','2013-10-27','NSRP'),(6502,8324,'cation transmembrane transporter activity','F','Catalysis of the transfer of cation from one side of the membrane to the other.','2013-10-27','NSRP'),(6503,8327,'methyl-CpG binding','F','Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide.','2013-10-27','NSRP'),(6504,8328,'ionotropic glutamate receptor complex','C','A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex.','2013-10-27','NSRP'),(6505,8329,'signaling pattern recognition receptor activity','F','Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity.','2013-10-27','NSRP'),(6506,8330,'protein tyrosine/threonine phosphatase activity','F','Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.','2013-10-27','NSRP'),(6507,8331,'high voltage-gated calcium channel activity','F','Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(6508,8332,'low voltage-gated calcium channel activity','F','Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(6509,8333,'endosome to lysosome transport','P','The directed movement of substances from endosomes to lysosomes.','2013-10-27','NSRP'),(6510,8334,'histone mRNA metabolic process','P','The chemical reactions and pathways involving an mRNA encoding a histone.','2013-10-27','NSRP'),(6511,8335,'female germline ring canal stabilization','P','Maintenance of the structural integrity of the ring canals connecting the female germline cyst.','2013-10-27','NSRP'),(6512,8336,'gamma-butyrobetaine dioxygenase activity','F','Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate.','2013-10-27','NSRP'),(6513,8337,'selectin','F','OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins.','2013-10-27','NSRP'),(6514,8340,'determination of adult lifespan','P','The control of viability and duration in the adult phase of the life-cycle.','2013-10-27','NSRP'),(6515,8341,'response to cocaine (sensu Insecta)','P','OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557).','2013-10-27','NSRP'),(6516,8342,'larval feeding behavior (sensu Insecta)','P','OBSOLETE. Feeding behavior in an insect larva.','2013-10-27','NSRP'),(6517,8343,'adult feeding behavior','P','Feeding behavior in a fully developed and mature organism.','2013-10-27','NSRP'),(6518,8344,'adult locomotory behavior','P','Locomotory behavior in a fully developed and mature organism.','2013-10-27','NSRP'),(6519,8345,'larval locomotory behavior','P','Locomotory behavior in a larval (immature) organism.','2013-10-27','NSRP'),(6520,8346,'larval walking behavior','P','The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.','2013-10-27','NSRP'),(6521,8347,'glial cell migration','P','The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.','2013-10-27','NSRP'),(6522,8348,'negative regulation of antimicrobial humoral response','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.','2013-10-27','NSRP'),(6523,8349,'MAP kinase kinase kinase kinase activity','F','Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.','2013-10-27','NSRP'),(6524,8350,'kinetochore motor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6525,8351,'microtubule severing activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6526,8352,'katanin complex','C','A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa).','2013-10-27','NSRP'),(6527,8353,'RNA polymerase II carboxy-terminal domain kinase activity','F','Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats.','2013-10-27','NSRP'),(6528,8354,'germ cell migration','P','The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.','2013-10-27','NSRP'),(6529,8355,'olfactory learning','P','Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.','2013-10-27','NSRP'),(6530,8356,'asymmetric cell division','P','The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.','2013-10-27','NSRP'),(6531,8358,'maternal determination of anterior/posterior axis, embryo','P','The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos.','2013-10-27','NSRP'),(6532,8359,'regulation of bicoid mRNA localization','P','Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location.','2013-10-27','NSRP'),(6533,8360,'regulation of cell shape','P','Any process that modulates the surface configuration of a cell.','2013-10-27','NSRP'),(6534,8361,'regulation of cell size','P','Any process that modulates the size of a cell.','2013-10-27','NSRP'),(6535,8362,'chitin-based embryonic cuticle biosynthetic process','P','Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6536,8363,'larval chitin-based cuticle development','P','Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6537,8364,'pupal chitin-based cuticle development','P','Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6538,8365,'adult chitin-based cuticle development','P','Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster.','2013-10-27','NSRP'),(6539,8366,'axon ensheathment','P','Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.','2013-10-27','NSRP'),(6540,8369,'obsolete molecular function','F','OBSOLETE. These are terms that have been removed from the active function ontology.','2013-10-27','NSRP'),(6541,8370,'obsolete cellular component','C','OBSOLETE. These are terms that have been removed from the active component ontology.','2013-10-27','NSRP'),(6542,8371,'obsolete biological process','P','OBSOLETE. These are terms that have been removed from the active process ontology.','2013-10-27','NSRP'),(6543,8373,'sialyltransferase activity','F','Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.','2013-10-27','NSRP'),(6544,8374,'O-acyltransferase activity','F','Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule.','2013-10-27','NSRP'),(6545,8375,'acetylglucosaminyltransferase activity','F','Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar.','2013-10-27','NSRP'),(6546,8376,'acetylgalactosaminyltransferase activity','F','Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide.','2013-10-27','NSRP'),(6547,8377,'light-induced release of internally sequestered calcium ion','P','The process in which the detection of light triggers the release of internally sequestered calcium ions.','2013-10-27','NSRP'),(6548,8378,'galactosyltransferase activity','F','Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid.','2013-10-27','NSRP'),(6549,8379,'thioredoxin peroxidase activity','F','Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.','2013-10-27','NSRP'),(6550,8380,'RNA splicing','P','The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.','2013-10-27','NSRP'),(6551,8381,'mechanically-gated ion channel activity','F','Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress.','2013-10-27','NSRP'),(6552,8384,'IkappaB kinase activity','F','Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.','2013-10-27','NSRP'),(6553,8385,'IkappaB kinase complex','C','A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.','2013-10-27','NSRP'),(6554,8386,'cholesterol monooxygenase (side-chain-cleaving) activity','F','Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.','2013-10-27','NSRP'),(6555,8387,'steroid 7-alpha-hydroxylase activity','F','Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O.','2013-10-27','NSRP'),(6556,8388,'testosterone 15-alpha-hydroxylase activity','F','Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O.','2013-10-27','NSRP'),(6557,8389,'coumarin 7-hydroxylase activity','F','Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+.','2013-10-27','NSRP'),(6558,8390,'testosterone 16-alpha-hydroxylase activity','F','Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-alpha-hydroxytestosterone + H2O.','2013-10-27','NSRP'),(6559,8391,'arachidonic acid monooxygenase activity','F','Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water.','2013-10-27','NSRP'),(6560,8392,'arachidonic acid epoxygenase activity','F','Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid.','2013-10-27','NSRP'),(6561,8395,'steroid hydroxylase activity','F','Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2.','2013-10-27','NSRP'),(6562,8396,'oxysterol 7-alpha-hydroxylase activity','F','Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O.','2013-10-27','NSRP'),(6563,8397,'sterol 12-alpha-hydroxylase activity','F','Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O.','2013-10-27','NSRP'),(6564,8398,'sterol 14-demethylase activity','F','Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O.','2013-10-27','NSRP'),(6565,8399,'naphthalene hydroxylase activity','F','Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide.','2013-10-27','NSRP'),(6566,8401,'retinoic acid 4-hydroxylase activity','F','Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.','2013-10-27','NSRP'),(6567,8403,'25-hydroxycholecalciferol-24-hydroxylase activity','F','Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol.','2013-10-27','NSRP'),(6568,8404,'arachidonic acid 14,15-epoxygenase activity','F','Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid.','2013-10-27','NSRP'),(6569,8405,'arachidonic acid 11,12-epoxygenase activity','F','Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid.','2013-10-27','NSRP'),(6570,8406,'gonad development','P','The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.','2013-10-27','NSRP'),(6571,8407,'chaeta morphogenesis','P','The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.','2013-10-27','NSRP'),(6572,8408,'3\'-5\' exonuclease activity','F','Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3\' end.','2013-10-27','NSRP'),(6573,8409,'5\'-3\' exonuclease activity','F','Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5\' end.','2013-10-27','NSRP'),(6574,8410,'CoA-transferase activity','F','Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).','2013-10-27','NSRP'),(6575,8411,'4-hydroxybutyrate CoA-transferase activity','F','Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate.','2013-10-27','NSRP'),(6576,8412,'4-hydroxybenzoate octaprenyltransferase activity','F','Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate.','2013-10-27','NSRP'),(6577,8413,'8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity','F','Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription.','2013-10-27','NSRP'),(6578,8414,'CDP-alcohol phosphotransferase activity','F','Catalysis of the transfer of a CDP-alcohol group from one compound to another.','2013-10-27','NSRP'),(6579,8416,'delta5-delta2,4-dienoyl-CoA isomerase activity','F','Catalysis of the isomerization of 3,5-dienoyl-CoA to 2,4-dienoyl-CoA.','2013-10-27','NSRP'),(6580,8417,'fucosyltransferase activity','F','Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid.','2013-10-27','NSRP'),(6581,8418,'protein-N-terminal asparagine amidohydrolase activity','F','Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein.','2013-10-27','NSRP'),(6582,8419,'RNA lariat debranching enzyme activity','F','Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2\'-5\'- and 3\'-5\'-phosphodiester bonds at a branch point nucleotide.','2013-10-27','NSRP'),(6583,8420,'CTD phosphatase activity','F','Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate.','2013-10-27','NSRP'),(6584,8421,'long-chain fatty-acyl-glutamate deacylase activity','F','Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate.','2013-10-27','NSRP'),(6585,8422,'beta-glucosidase activity','F','Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose.','2013-10-27','NSRP'),(6586,8423,'bleomycin hydrolase activity','F','OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.','2013-10-27','NSRP'),(6587,8424,'glycoprotein 6-alpha-L-fucosyltransferase activity','F','Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+).','2013-10-27','NSRP'),(6588,8425,'2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity','F','Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(6589,8426,'protein kinase C inhibitor activity','F','Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein.','2013-10-27','NSRP'),(6590,8427,'calcium-dependent protein kinase inhibitor activity','F','Stops, prevents or reduces the activity of a calcium-dependent protein kinase.','2013-10-27','NSRP'),(6591,8428,'ribonuclease inhibitor activity','F','Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA.','2013-10-27','NSRP'),(6592,8429,'phosphatidylethanolamine binding','F','Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.','2013-10-27','NSRP'),(6593,8430,'selenium binding','F','Interacting selectively and non-covalently with selenium (Se).','2013-10-27','NSRP'),(6594,8431,'vitamin E binding','F','Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.','2013-10-27','NSRP'),(6595,8432,'JUN kinase binding','F','Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family.','2013-10-27','NSRP'),(6596,8434,'calcitriol receptor activity','F','Combining with calcitriol, the hormonally active form of vitamin D3, and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.','2013-10-27','NSRP'),(6597,8435,'anticoagulant activity','F','OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation.','2013-10-27','NSRP'),(6598,8436,'heterogeneous nuclear ribonucleoprotein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6599,8437,'thyrotropin-releasing hormone activity','F','The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary.','2013-10-27','NSRP'),(6600,8438,'1-phosphatidylinositol-5-phosphate kinase','F','OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide.','2013-10-27','NSRP'),(6601,8439,'monophenol monooxygenase activator activity','F','OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase.','2013-10-27','NSRP'),(6602,8440,'inositol-1,4,5-trisphosphate 3-kinase activity','F','Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(6603,8441,'3\'(2\'),5\'-bisphosphate nucleotidase activity','F','Catalysis of the reaction: adenosine 3\',5\'-bisphosphate + H2O = adenosine 5\'-phosphate + phosphate.','2013-10-27','NSRP'),(6604,8442,'3-hydroxyisobutyrate dehydrogenase activity','F','Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+.','2013-10-27','NSRP'),(6605,8443,'phosphofructokinase activity','F','Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule.','2013-10-27','NSRP'),(6606,8444,'CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity','F','Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+).','2013-10-27','NSRP'),(6607,8445,'D-aspartate oxidase activity','F','Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide.','2013-10-27','NSRP'),(6608,8446,'GDP-mannose 4,6-dehydratase activity','F','Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O.','2013-10-27','NSRP'),(6609,8447,'L-ascorbate oxidase activity','F','Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O.','2013-10-27','NSRP'),(6610,8448,'N-acetylglucosamine-6-phosphate deacetylase activity','F','Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.','2013-10-27','NSRP'),(6611,8449,'N-acetylglucosamine-6-sulfatase activity','F','Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.','2013-10-27','NSRP'),(6612,8450,'O-sialoglycoprotein endopeptidase activity','F','OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated.','2013-10-27','NSRP'),(6613,8451,'X-Pro aminopeptidase activity','F','OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.','2013-10-27','NSRP'),(6614,8452,'RNA ligase activity','F','Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5\'-phosphate group at the end of another.','2013-10-27','NSRP'),(6615,8453,'alanine-glyoxylate transaminase activity','F','Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine.','2013-10-27','NSRP'),(6616,8454,'alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R.','2013-10-27','NSRP'),(6617,8455,'alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R.','2013-10-27','NSRP'),(6618,8456,'alpha-N-acetylgalactosaminidase activity','F','Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.','2013-10-27','NSRP'),(6619,8457,'beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide.','2013-10-27','NSRP'),(6620,8458,'carnitine O-octanoyltransferase activity','F','Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA.','2013-10-27','NSRP'),(6621,8459,'chondroitin 6-sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + chondroitin = adenosine 3\',5\'-bisphosphate + chondroitin 6\'-sulfate.','2013-10-27','NSRP'),(6622,8460,'dTDP-glucose 4,6-dehydratase activity','F','Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O.','2013-10-27','NSRP'),(6623,8462,'endopeptidase Clp activity','F','OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs).','2013-10-27','NSRP'),(6624,8463,'formylmethionine deformylase activity','F','Catalysis of the reaction: N-formyl-L-methionine + H(2)O = L-methionine + formate.','2013-10-27','NSRP'),(6625,8464,'gamma-glutamyl hydrolase activity','F','OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid.','2013-10-27','NSRP'),(6626,8465,'glycerate dehydrogenase activity','F','Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+.','2013-10-27','NSRP'),(6627,8466,'glycogenin glucosyltransferase activity','F','Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin.','2013-10-27','NSRP'),(6628,8467,'[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity','F','Catalysis of the reaction: 3\'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3\',5\'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S.','2013-10-27','NSRP'),(6629,8469,'histone-arginine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine.','2013-10-27','NSRP'),(6630,8470,'isovaleryl-CoA dehydrogenase activity','F','Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF.','2013-10-27','NSRP'),(6631,8471,'laccase activity','F','OBSOLETE. Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.','2013-10-27','NSRP'),(6632,8472,'metallocarboxypeptidase D activity','F','OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid.','2013-10-27','NSRP'),(6633,8473,'ornithine cyclodeaminase activity','F','Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+).','2013-10-27','NSRP'),(6634,8474,'palmitoyl-(protein) hydrolase activity','F','Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.','2013-10-27','NSRP'),(6635,8475,'procollagen-lysine 5-dioxygenase activity','F','Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.','2013-10-27','NSRP'),(6636,8476,'protein-tyrosine sulfotransferase activity','F','Catalysis of the reaction: 3\'-phosphoadenosine 5\'-phosphosulfate + protein tyrosine = adenosine 3\',5\'-bisphosphate + protein tyrosine-O-sulfate.','2013-10-27','NSRP'),(6637,8477,'purine nucleosidase activity','F','Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose.','2013-10-27','NSRP'),(6638,8478,'pyridoxal kinase activity','F','Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5\'-phosphate.','2013-10-27','NSRP'),(6639,8479,'queuine tRNA-ribosyltransferase activity','F','Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine.','2013-10-27','NSRP'),(6640,8480,'sarcosine dehydrogenase activity','F','Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein.','2013-10-27','NSRP'),(6641,8481,'sphinganine kinase activity','F','Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate.','2013-10-27','NSRP'),(6642,8482,'sulfite oxidase activity','F','Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate.','2013-10-27','NSRP'),(6643,8483,'transaminase activity','F','Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.','2013-10-27','NSRP'),(6644,8484,'sulfuric ester hydrolase activity','F','Catalysis of the reaction: RSO-R\' + H2O = RSOOH + R\'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2.','2013-10-27','NSRP'),(6645,8486,'diphosphoinositol-polyphosphate diphosphatase activity','F','Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate.','2013-10-27','NSRP'),(6646,8487,'prenyl-dependent CAAX protease activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6647,8488,'gamma-glutamyl carboxylase activity','F','Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide.','2013-10-27','NSRP'),(6648,8489,'UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity','F','Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5\'-diphosphate. The glucosylceramide has sphinganine as the long chain base.','2013-10-27','NSRP'),(6649,8490,'arsenite secondary active transmembrane transporter activity','F','Catalysis of the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.','2013-10-27','NSRP'),(6650,8492,'cAMP generating peptide activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6651,8493,'tetracycline transporter activity','F','Enables the directed movement of tetracycline into, out of or within a cell, or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles).','2013-10-27','NSRP'),(6652,8494,'translation activator activity','F','Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide.','2013-10-27','NSRP'),(6653,8495,'protoheme IX farnesyltransferase activity','F','Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate.','2013-10-27','NSRP'),(6654,8496,'mannan endo-1,6-alpha-mannosidase activity','F','Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans.','2013-10-27','NSRP'),(6655,8498,'phospholipid scrambling','F','OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions.','2013-10-27','NSRP'),(6656,8499,'UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity','F','Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP.','2013-10-27','NSRP'),(6657,8500,'glycine-, glutamate-, thienylcyclohexylpiperidine binding','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6658,8502,'melatonin receptor activity','F','Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin.','2013-10-27','NSRP'),(6659,8503,'benzodiazepine receptor activity','F','Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity.','2013-10-27','NSRP'),(6660,8504,'monoamine transmembrane transporter activity','F','Catalysis of the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other.','2013-10-27','NSRP'),(6661,8506,'sucrose:hydrogen symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in).','2013-10-27','NSRP'),(6662,8507,'sodium:iodide symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in).','2013-10-27','NSRP'),(6663,8508,'bile acid:sodium symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in).','2013-10-27','NSRP'),(6664,8509,'anion transmembrane transporter activity','F','Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other.','2013-10-27','NSRP'),(6665,8510,'sodium:bicarbonate symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in).','2013-10-27','NSRP'),(6666,8511,'sodium:potassium:chloride symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).','2013-10-27','NSRP'),(6667,8512,'sulfate:hydrogen symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in).','2013-10-27','NSRP'),(6668,8513,'secondary active organic cation transmembrane transporter activity','F','Catalysis of the transfer of organic cations from one side of the membrane to the other, up the solute\'s concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction.','2013-10-27','NSRP'),(6669,8514,'organic anion transmembrane transporter activity','F','Catalysis of the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.','2013-10-27','NSRP'),(6670,8515,'sucrose transmembrane transporter activity','F','Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane.','2013-10-27','NSRP'),(6671,8516,'hexose uniporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in).','2013-10-27','NSRP'),(6672,8517,'folic acid transporter activity','F','Enables the directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.','2013-10-27','NSRP'),(6673,8518,'reduced folate carrier activity','F','Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport.','2013-10-27','NSRP'),(6674,8519,'ammonium transmembrane transporter activity','F','Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.','2013-10-27','NSRP'),(6675,8520,'L-ascorbate:sodium symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in).','2013-10-27','NSRP'),(6676,8521,'acetyl-CoA transporter activity','F','Enables the directed movement of acetyl-CoA into, out of or within a cell, or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.','2013-10-27','NSRP'),(6677,8523,'sodium-dependent multivitamin transmembrane transporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate.','2013-10-27','NSRP'),(6678,8524,'glucose 6-phosphate:phosphate antiporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out).','2013-10-27','NSRP'),(6679,8525,'phosphatidylcholine transporter activity','F','Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.','2013-10-27','NSRP'),(6680,8526,'phosphatidylinositol transporter activity','F','Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.','2013-10-27','NSRP'),(6681,8527,'taste receptor activity','F','Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste.','2013-10-27','NSRP'),(6682,8528,'G-protein coupled peptide receptor activity','F','Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(6683,8529,'endogenous peptide receptor activity','F','OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity.','2013-10-27','NSRP'),(6684,8530,'exogenous peptide receptor activity','F','OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity.','2013-10-27','NSRP'),(6685,8531,'riboflavin kinase activity','F','Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+).','2013-10-27','NSRP'),(6686,8532,'N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.','2013-10-27','NSRP'),(6687,8533,'astacin activity','F','OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1\', and Pro in P2\'.','2013-10-27','NSRP'),(6688,8534,'oxidized purine nucleobase lesion DNA N-glycosylase activity','F','Catalysis of the removal of oxidized purine bases by cleaving the N-C1\' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3\' of the apurinic (AP) site.','2013-10-27','NSRP'),(6689,8535,'respiratory chain complex IV assembly','P','The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms.','2013-10-27','NSRP'),(6690,8536,'Ran GTPase binding','F','Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.','2013-10-27','NSRP'),(6691,8537,'proteasome activator complex','C','A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex.','2013-10-27','NSRP'),(6692,8538,'proteasome activator activity','F','OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis.','2013-10-27','NSRP'),(6693,8539,'proteasome inhibitor activity','F','OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis.','2013-10-27','NSRP'),(6694,8540,'proteasome regulatory particle, base subcomplex','C','The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex.','2013-10-27','NSRP'),(6695,8541,'proteasome regulatory particle, lid subcomplex','C','The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.','2013-10-27','NSRP'),(6696,8542,'visual learning','P','Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue.','2013-10-27','NSRP'),(6697,8543,'fibroblast growth factor receptor signaling pathway','P','The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.','2013-10-27','NSRP'),(6698,8544,'epidermis development','P','The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.','2013-10-27','NSRP'),(6699,8545,'JUN kinase kinase activity','F','Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase.','2013-10-27','NSRP'),(6700,8546,'microtubule/chromatin interaction','P','OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins.','2013-10-27','NSRP'),(6701,8547,'protein-synthesizing GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs.','2013-10-27','NSRP'),(6702,8548,'signal-recognition-particle GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis.','2013-10-27','NSRP'),(6703,8549,'dynamin GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles.','2013-10-27','NSRP'),(6704,8550,'tubulin GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others.','2013-10-27','NSRP'),(6705,8551,'cadmium-exporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) -> ADP + phosphate + Cd2+(out).','2013-10-27','NSRP'),(6706,8552,'zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity','F','OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+.','2013-10-27','NSRP'),(6707,8553,'hydrogen-exporting ATPase activity, phosphorylative mechanism','F','Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle.','2013-10-27','NSRP'),(6708,8554,'sodium-exporting ATPase activity, phosphorylative mechanism','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism.','2013-10-27','NSRP'),(6709,8555,'chloride-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in).','2013-10-27','NSRP'),(6710,8556,'potassium-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in).','2013-10-27','NSRP'),(6711,8558,'guanine-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in).','2013-10-27','NSRP'),(6712,8559,'xenobiotic-transporting ATPase activity','F','Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).','2013-10-27','NSRP'),(6713,8563,'alpha-factor sex pheromone exporter','F','OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process.','2013-10-27','NSRP'),(6714,8564,'protein-exporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.','2013-10-27','NSRP'),(6715,8565,'protein transporter activity','F','Enables the directed movement of proteins into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(6716,8566,'mitochondrial protein-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex.','2013-10-27','NSRP'),(6717,8567,'dynein ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome.','2013-10-27','NSRP'),(6718,8568,'microtubule-severing ATPase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.','2013-10-27','NSRP'),(6719,8569,'minus-end-directed microtubule motor activity','F','Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP (or GTP).','2013-10-27','NSRP'),(6720,8570,'myosin ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction.','2013-10-27','NSRP'),(6721,8571,'non-chaperonin molecular chaperone ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin.','2013-10-27','NSRP'),(6722,8572,'nucleoplasmin ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes.','2013-10-27','NSRP'),(6723,8573,'peroxisome-assembly ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle.','2013-10-27','NSRP'),(6724,8574,'plus-end-directed microtubule motor activity','F','Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP (or GTP).','2013-10-27','NSRP'),(6725,8575,'proteasome ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.','2013-10-27','NSRP'),(6726,8576,'vesicle-fusing ATPase activity','F','OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.','2013-10-27','NSRP'),(6727,8579,'JUN kinase phosphatase activity','F','Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate.','2013-10-27','NSRP'),(6728,8580,'cytoskeletal regulator activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6729,8581,'ubiquitin-specific protease 5 activity','F','OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin.','2013-10-27','NSRP'),(6730,8582,'regulation of synaptic growth at neuromuscular junction','P','Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.','2013-10-27','NSRP'),(6731,8583,'mystery cell differentiation','P','The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6732,8584,'male gonad development','P','The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6733,8585,'female gonad development','P','The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.','2013-10-27','NSRP'),(6734,8586,'imaginal disc-derived wing vein morphogenesis','P','The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.','2013-10-27','NSRP'),(6735,8587,'imaginal disc-derived wing margin morphogenesis','P','The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade.','2013-10-27','NSRP'),(6736,8588,'release of cytoplasmic sequestered NF-kappaB','P','The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus.','2013-10-27','NSRP'),(6737,8589,'regulation of smoothened signaling pathway','P','Any process that modulates the frequency, rate or extent of smoothened signaling.','2013-10-27','NSRP'),(6738,8591,'regulation of Wnt receptor signaling pathway, calcium modulating pathway','P','Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).','2013-10-27','NSRP'),(6739,8592,'regulation of Toll signaling pathway','P','Any process that modulates the frequency, rate or extent of the Tl signaling pathway.','2013-10-27','NSRP'),(6740,8593,'regulation of Notch signaling pathway','P','Any process that modulates the frequency, rate or extent of the Notch signaling pathway.','2013-10-27','NSRP'),(6741,8594,'photoreceptor cell morphogenesis','P','The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(6742,8595,'anterior/posterior axis specification, embryo','P','The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote.','2013-10-27','NSRP'),(6743,8597,'calcium-dependent protein serine/threonine phosphatase regulator activity','F','Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase.','2013-10-27','NSRP'),(6744,8599,'protein phosphatase type 1 regulator activity','F','Modulation of the activity of the enzyme protein phosphatase type 1.','2013-10-27','NSRP'),(6745,8601,'protein phosphatase type 2A regulator activity','F','Modulation of the activity of the enzyme protein phosphatase type 2A.','2013-10-27','NSRP'),(6746,8603,'cAMP-dependent protein kinase regulator activity','F','Modulation of the activity of the enzyme cAMP-dependent protein kinase.','2013-10-27','NSRP'),(6747,8605,'protein kinase CK2 regulator activity','F','OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2.','2013-10-27','NSRP'),(6748,8607,'phosphorylase kinase regulator activity','F','Modulation of the activity of the enzyme phosphorylase kinase.','2013-10-27','NSRP'),(6749,8608,'attachment of spindle microtubules to kinetochore','P','The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.','2013-10-27','NSRP'),(6750,8609,'alkylglycerone-phosphate synthase activity','F','Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion.','2013-10-27','NSRP'),(6751,8610,'lipid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.','2013-10-27','NSRP'),(6752,8611,'ether lipid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol.','2013-10-27','NSRP'),(6753,8612,'peptidyl-lysine modification to hypusine','P','The modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.','2013-10-27','NSRP'),(6754,8613,'diuretic hormone activity','F','The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion.','2013-10-27','NSRP'),(6755,8614,'pyridoxine metabolic process','P','The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.','2013-10-27','NSRP'),(6756,8615,'pyridoxine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds.','2013-10-27','NSRP'),(6757,8616,'queuosine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.','2013-10-27','NSRP'),(6758,8617,'guanosine metabolic process','P','The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution.','2013-10-27','NSRP'),(6759,8618,'7-methylguanosine metabolic process','P','The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5\'-terminus of eukaryotic mRNA.','2013-10-27','NSRP'),(6760,8619,'RHEB small monomeric GTPase activity','F','OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate.','2013-10-27','NSRP'),(6761,8622,'epsilon DNA polymerase complex','C','A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.','2013-10-27','NSRP'),(6762,8623,'CHRAC','C','An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair.','2013-10-27','NSRP'),(6763,8624,'induction of apoptosis by extracellular signals','P','Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis.','2012-03-14','NSRP'),(6764,8625,'extrinsic apoptotic signaling pathway via death domain receptors','P','A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.','2013-10-27','NSRP'),(6765,8626,'granzyme-mediated apoptotic signaling pathway','P','A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.','2013-10-27','NSRP'),(6766,8627,'intrinsic apoptotic signaling pathway in response to osmotic stress','P','A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered.','2013-10-27','NSRP'),(6767,8628,'hormone-mediated apoptotic signaling pathway','P','A series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered.','2013-10-27','NSRP'),(6768,8629,'induction of apoptosis by intracellular signals','P','Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis.','2012-03-14','NSRP'),(6769,8630,'intrinsic apoptotic signaling pathway in response to DNA damage','P','A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.','2013-10-27','NSRP'),(6770,8631,'intrinsic apoptotic signaling pathway in response to oxidative stress','P','A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.','2013-10-27','NSRP'),(6771,8633,'activation of pro-apoptotic gene products','P','OBSOLETE. The conversion of proteins that induce or sustain apoptosis to an active form.','2013-10-27','NSRP'),(6772,8634,'negative regulation of survival gene product expression','P','OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level.','2013-10-27','NSRP'),(6773,8635,'activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c','P','Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c.','2013-10-27','NSRP'),(6774,8636,'activation of caspase activity by protein phosphorylation','P','OBSOLETE. Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group.','2013-10-27','NSRP'),(6775,8637,'apoptotic mitochondrial changes','P','The morphological and physiological alterations undergone by mitochondria during apoptosis.','2013-10-27','NSRP'),(6776,8638,'protein tagging activity','F','OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation.','2013-10-27','NSRP'),(6777,8641,'small protein activating enzyme activity','F','Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.','2013-10-27','NSRP'),(6778,8643,'carbohydrate transport','P','The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y.','2013-10-27','NSRP'),(6779,8645,'hexose transport','P','The directed movement of hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.','2013-10-27','NSRP'),(6780,8646,'high-affinity hexose transport','P','The directed, high-affinity movement of a hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.','2013-10-27','NSRP'),(6781,8647,'low-affinity hexose transport','P','The directed, low-affinity movement of a hexose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations.','2013-10-27','NSRP'),(6782,8648,'tachykinin','F','OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation.','2013-10-27','NSRP'),(6783,8649,'rRNA methyltransferase activity','F','Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule.','2013-10-27','NSRP'),(6784,8650,'rRNA (uridine-2\'-O-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2\'-O-methyluridine.','2013-10-27','NSRP'),(6785,8651,'actin polymerizing activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6786,8652,'cellular amino acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.','2013-10-27','NSRP'),(6787,8653,'lipopolysaccharide metabolic process','P','The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.','2013-10-27','NSRP'),(6788,8654,'phospholipid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester.','2013-10-27','NSRP'),(6789,8655,'pyrimidine-containing compound salvage','P','Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis.','2013-10-27','NSRP'),(6790,8656,'cysteine-type endopeptidase activator activity involved in apoptotic process','F','Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process.','2013-10-27','NSRP'),(6791,8657,'DNA topoisomerase (ATP-hydrolyzing) inhibitor activity','F','Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.','2013-10-27','NSRP'),(6792,8658,'penicillin binding','F','Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.','2013-10-27','NSRP'),(6793,8659,'(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity','F','Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O.','2013-10-27','NSRP'),(6794,8660,'1-aminocyclopropane-1-carboxylate deaminase activity','F','Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanate + NH(4)(+).','2013-10-27','NSRP'),(6795,8661,'1-deoxy-D-xylulose-5-phosphate synthase activity','F','Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2).','2013-10-27','NSRP'),(6796,8662,'1-phosphofructokinase activity','F','Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate.','2013-10-27','NSRP'),(6797,8663,'2\',3\'-cyclic-nucleotide 2\'-phosphodiesterase activity','F','Catalysis of the reaction: nucleoside 2\',3\'-cyclic phosphate + H2O = nucleoside 3\'-phosphate.','2013-10-27','NSRP'),(6798,8664,'2\'-5\'-RNA ligase activity','F','Catalysis of the formation of a phosphodiester bond between the 2\'-hydroxyl group at the end of one DNA chain and the 5\'-phosphate group at the end of another.','2013-10-27','NSRP'),(6799,8665,'2\'-phosphotransferase activity','F','Catalysis of the transfer of a phosphate group from one compound to the 2\' position of another.','2013-10-27','NSRP'),(6800,8666,'2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity','F','Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H(2)O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA.','2013-10-27','NSRP'),(6801,8667,'2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity','F','Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH.','2013-10-27','NSRP'),(6802,8668,'(2,3-dihydroxybenzoyl)adenylate synthase activity','F','Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5\'-adenylate + diphosphate.','2013-10-27','NSRP'),(6803,8670,'2,4-dienoyl-CoA reductase (NADPH) activity','F','Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+.','2013-10-27','NSRP'),(6804,8671,'2-dehydro-3-deoxygalactonokinase activity','F','Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H(+).','2013-10-27','NSRP'),(6805,8672,'2-dehydro-3-deoxyglucarate aldolase activity','F','Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde.','2013-10-27','NSRP'),(6806,8673,'2-dehydro-3-deoxygluconokinase activity','F','Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H(+).','2013-10-27','NSRP'),(6807,8674,'2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity','F','Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate.','2013-10-27','NSRP'),(6808,8675,'2-dehydro-3-deoxy-phosphogluconate aldolase activity','F','Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate.','2013-10-27','NSRP'),(6809,8676,'3-deoxy-8-phosphooctulonate synthase activity','F','Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate.','2013-10-27','NSRP'),(6810,8677,'2-dehydropantoate 2-reductase activity','F','Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH.','2013-10-27','NSRP'),(6811,8678,'2-deoxy-D-gluconate 3-dehydrogenase activity','F','Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+.','2013-10-27','NSRP'),(6812,8679,'2-hydroxy-3-oxopropionate reductase activity','F','Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+.','2013-10-27','NSRP'),(6813,8681,'2-octaprenyl-6-methoxyphenol hydroxylase activity','F','Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O.','2013-10-27','NSRP'),(6814,8682,'2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity','F','Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone.','2013-10-27','NSRP'),(6815,8683,'2-oxoglutarate decarboxylase activity','F','Catalysis of the reaction: 2-oxoglutarate + H(+) = CO(2) + succinate semialdehyde.','2013-10-27','NSRP'),(6816,8684,'2-oxopent-4-enoate hydratase activity','F','Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O.','2013-10-27','NSRP'),(6817,8685,'2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity','F','Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP.','2013-10-27','NSRP'),(6818,8686,'3,4-dihydroxy-2-butanone-4-phosphate synthase activity','F','Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+).','2013-10-27','NSRP'),(6819,8687,'3,4-dihydroxyphenylacetate 2,3-dioxygenase activity','F','Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O(2) = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H(+).','2013-10-27','NSRP'),(6820,8688,'3-(3-hydroxyphenyl)propionate hydroxylase activity','F','Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O.','2013-10-27','NSRP'),(6821,8689,'3-demethylubiquinone-9 3-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9.','2013-10-27','NSRP'),(6822,8690,'3-deoxy-manno-octulosonate cytidylyltransferase activity','F','Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.','2013-10-27','NSRP'),(6823,8691,'3-hydroxybutyryl-CoA dehydrogenase activity','F','Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+.','2013-10-27','NSRP'),(6824,8692,'3-hydroxybutyryl-CoA epimerase activity','F','Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.','2013-10-27','NSRP'),(6825,8693,'3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity','F','Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O.','2013-10-27','NSRP'),(6826,8694,'3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity','F','Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2.','2013-10-27','NSRP'),(6827,8695,'3-phenylpropionate dioxygenase activity','F','Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol.','2013-10-27','NSRP'),(6828,8696,'4-amino-4-deoxychorismate lyase activity','F','Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate.','2013-10-27','NSRP'),(6829,8697,'4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity','F','Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate.','2013-10-27','NSRP'),(6830,8700,'4-hydroxy-2-oxoglutarate aldolase activity','F','Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.','2013-10-27','NSRP'),(6831,8701,'4-hydroxy-2-oxovalerate aldolase activity','F','Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.','2013-10-27','NSRP'),(6832,8703,'5-amino-6-(5-phosphoribosylamino)uracil reductase activity','F','Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH.','2013-10-27','NSRP'),(6833,8704,'5-carboxymethyl-2-hydroxymuconate delta-isomerase activity','F','Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate.','2013-10-27','NSRP'),(6834,8705,'methionine synthase activity','F','Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.','2013-10-27','NSRP'),(6835,8706,'6-phospho-beta-glucosidase activity','F','Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose.','2013-10-27','NSRP'),(6836,8707,'4-phytase activity','F','Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate.','2013-10-27','NSRP'),(6837,8709,'cholate 7-alpha-dehydrogenase activity','F','Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.','2013-10-27','NSRP'),(6838,8710,'8-amino-7-oxononanoate synthase activity','F','Catalysis of the reaction: L-alanine + H(+) + pimelyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA.','2013-10-27','NSRP'),(6839,8711,'ADP-L-glycero-D-manno-heptose synthase activity','F','OBSOLETE.','2013-10-27','NSRP'),(6840,8712,'ADP-glyceromanno-heptose 6-epimerase activity','F','Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose.','2013-10-27','NSRP'),(6841,8713,'ADP-heptose-lipopolysaccharide heptosyltransferase activity','F','Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+.','2013-10-27','NSRP'),(6842,8714,'AMP nucleosidase activity','F','Catalysis of the reaction: AMP + H(2)O = D-ribose 5-phosphate + adenine.','2013-10-27','NSRP'),(6843,8715,'CDP-diacylglycerol diphosphatase activity','F','Catalysis of the reaction: CDP-diacylglycerol + H(2)O = a phosphatidate + CMP + 2 H(+).','2013-10-27','NSRP'),(6844,8716,'D-alanine-D-alanine ligase activity','F','Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H(+) + phosphate.','2013-10-27','NSRP'),(6845,8717,'D-alanyl-D-alanine endopeptidase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6846,8718,'D-amino-acid dehydrogenase activity','F','Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor.','2013-10-27','NSRP'),(6847,8719,'dihydroneopterin triphosphate 2\'-epimerase activity','F','Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate.','2013-10-27','NSRP'),(6848,8720,'D-lactate dehydrogenase activity','F','Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate.','2013-10-27','NSRP'),(6849,8721,'D-serine ammonia-lyase activity','F','Catalysis of the reaction: D-serine = pyruvate + NH3.','2013-10-27','NSRP'),(6850,8724,'DNA topoisomerase IV activity','F','OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo.','2013-10-27','NSRP'),(6851,8725,'DNA-3-methyladenine glycosylase activity','F','Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1\' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.','2013-10-27','NSRP'),(6852,8726,'alkanesulfonate monooxygenase activity','F','Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN.','2013-10-27','NSRP'),(6853,8727,'GDP-mannose mannosyl hydrolase activity','F','Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+.','2013-10-27','NSRP'),(6854,8728,'GTP diphosphokinase activity','F','Catalysis of the reaction: ATP + GTP = AMP + guanosine 3\'-diphosphate 5\'-triphosphate.','2013-10-27','NSRP'),(6855,8730,'L(+)-tartrate dehydratase activity','F','Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate.','2013-10-27','NSRP'),(6856,8732,'L-allo-threonine aldolase activity','F','Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde.','2013-10-27','NSRP'),(6857,8733,'L-arabinose isomerase activity','F','Catalysis of the reaction: L-arabinose = L-ribulose.','2013-10-27','NSRP'),(6858,8734,'L-aspartate oxidase activity','F','Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide.','2013-10-27','NSRP'),(6859,8735,'carnitine dehydratase activity','F','Catalysis of the reaction: (R)-carnitine = crotono-betaine + H(2)O.','2013-10-27','NSRP'),(6860,8736,'L-fucose isomerase activity','F','Catalysis of the reaction: L-fucose = L-fuculose.','2013-10-27','NSRP'),(6861,8737,'L-fuculokinase activity','F','Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(6862,8738,'L-fuculose-phosphate aldolase activity','F','Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate.','2013-10-27','NSRP'),(6863,8740,'L-rhamnose isomerase activity','F','Catalysis of the reaction: L-rhamnose = L-rhamnulose.','2013-10-27','NSRP'),(6864,8741,'ribulokinase activity','F','Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate.','2013-10-27','NSRP'),(6865,8742,'L-ribulose-phosphate 4-epimerase activity','F','Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate.','2013-10-27','NSRP'),(6866,8743,'L-threonine 3-dehydrogenase activity','F','Catalysis of the reaction: L-threonine + NAD(+) = aminoacetone + CO(2) + NADH.','2013-10-27','NSRP'),(6867,8744,'L-xylulokinase activity','F','Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate.','2013-10-27','NSRP'),(6868,8745,'N-acetylmuramoyl-L-alanine amidase activity','F','Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides.','2013-10-27','NSRP'),(6869,8746,'NAD(P)+ transhydrogenase activity','F','Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.','2013-10-27','NSRP'),(6870,8747,'N-acetylneuraminate lyase activity','F','Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.','2013-10-27','NSRP'),(6871,8748,'N-ethylmaleimide reductase activity','F','Catalysis of the reaction: N-ethylmaleimide + 2 H+ = N-ethylsuccinimide.','2013-10-27','NSRP'),(6872,8750,'NAD(P)+ transhydrogenase (AB-specific) activity','F','Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+.','2013-10-27','NSRP'),(6873,8751,'NAD(P)H dehydrogenase','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6874,8752,'FMN reductase activity','F','Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+.','2013-10-27','NSRP'),(6875,8753,'NADPH dehydrogenase (quinone) activity','F','Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor.','2013-10-27','NSRP'),(6876,8754,'O antigen ligase activity','F','Catalysis of the reaction: Lipid A-core + colanic acid = MLPS.','2013-10-27','NSRP'),(6877,8755,'O antigen polymerase activity','F','Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide.','2013-10-27','NSRP'),(6878,8756,'o-succinylbenzoate-CoA ligase activity','F','Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate.','2013-10-27','NSRP'),(6879,8757,'S-adenosylmethionine-dependent methyltransferase activity','F','Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.','2013-10-27','NSRP'),(6880,8758,'UDP-2,3-diacylglucosamine hydrolase activity','F','Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP.','2013-10-27','NSRP'),(6881,8759,'UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity','F','Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine.','2013-10-27','NSRP'),(6882,8760,'UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity','F','Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine.','2013-10-27','NSRP'),(6883,8761,'UDP-N-acetylglucosamine 2-epimerase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine.','2013-10-27','NSRP'),(6884,8762,'UDP-N-acetylmuramate dehydrogenase activity','F','Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+.','2013-10-27','NSRP'),(6885,8763,'UDP-N-acetylmuramate-L-alanine ligase activity','F','Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine.','2013-10-27','NSRP'),(6886,8764,'UDP-N-acetylmuramoylalanine-D-glutamate ligase activity','F','Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate.','2013-10-27','NSRP'),(6887,8765,'UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity','F','Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.','2013-10-27','NSRP'),(6888,8766,'UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity','F','Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine.','2013-10-27','NSRP'),(6889,8767,'UDP-galactopyranose mutase activity','F','Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose.','2013-10-27','NSRP'),(6890,8768,'UDP-sugar diphosphatase activity','F','Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate.','2013-10-27','NSRP'),(6891,8769,'X-His dipeptidase activity','F','OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides.','2013-10-27','NSRP'),(6892,8770,'[acyl-carrier-protein] phosphodiesterase activity','F','Catalysis of the reaction: [acyl-carrier protein] + H2O = 4\'-phosphopantetheine + apoprotein.','2013-10-27','NSRP'),(6893,8771,'[citrate (pro-3S)-lyase] ligase activity','F','Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form).','2013-10-27','NSRP'),(6894,8772,'[isocitrate dehydrogenase (NADP+)] kinase activity','F','Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate.','2013-10-27','NSRP'),(6895,8773,'[protein-PII] uridylyltransferase activity','F','Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII).','2013-10-27','NSRP'),(6896,8774,'acetaldehyde dehydrogenase (acetylating) activity','F','Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+.','2013-10-27','NSRP'),(6897,8775,'acetate CoA-transferase activity','F','Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.','2013-10-27','NSRP'),(6898,8776,'acetate kinase activity','F','Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate.','2013-10-27','NSRP'),(6899,8777,'acetylornithine deacetylase activity','F','Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine.','2013-10-27','NSRP'),(6900,8779,'acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity','F','Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.','2013-10-27','NSRP'),(6901,8780,'acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity','F','Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine.','2013-10-27','NSRP'),(6902,8781,'N-acylneuraminate cytidylyltransferase activity','F','Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate.','2013-10-27','NSRP'),(6903,8782,'adenosylhomocysteine nucleosidase activity','F','Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine.','2013-10-27','NSRP'),(6904,8783,'agmatinase activity','F','Catalysis of the reaction: agmatine + H(2)O = putrescine + urea.','2013-10-27','NSRP'),(6905,8784,'alanine racemase activity','F','Catalysis of the reaction: L-alanine = D-alanine.','2013-10-27','NSRP'),(6906,8785,'alkyl hydroperoxide reductase activity','F','Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.','2013-10-27','NSRP'),(6907,8786,'allose 6-phosphate isomerase activity','F','Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate.','2013-10-27','NSRP'),(6908,8787,'allose kinase activity','F','Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate.','2013-10-27','NSRP'),(6909,8788,'alpha,alpha-phosphotrehalase activity','F','Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate.','2013-10-27','NSRP'),(6910,8789,'altronate dehydratase activity','F','Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O.','2013-10-27','NSRP'),(6911,8790,'arabinose isomerase activity','F','Catalysis of the reaction: D-arabinose = D-ribulose.','2013-10-27','NSRP'),(6912,8791,'arginine N-succinyltransferase activity','F','Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine.','2013-10-27','NSRP'),(6913,8792,'arginine decarboxylase activity','F','Catalysis of the reaction: L-arginine + H(+) = agmatine + CO(2).','2013-10-27','NSRP'),(6914,8793,'aromatic-amino-acid:2-oxoglutarate aminotransferase activity','F','Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.','2013-10-27','NSRP'),(6915,8794,'arsenate reductase (glutaredoxin) activity','F','Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.','2013-10-27','NSRP'),(6916,8795,'NAD+ synthase activity','F','Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+.','2013-10-27','NSRP'),(6917,8796,'bis(5\'-nucleosyl)-tetraphosphatase activity','F','Catalysis of the hydrolysis of P(1),P(4)-bis(5\'-nucleosyl)tetraphosphate into two nucleotides.','2013-10-27','NSRP'),(6918,8797,'aspartate ammonia-lyase activity','F','Catalysis of the reaction: L-aspartate = fumarate + NH3.','2013-10-27','NSRP'),(6919,8798,'beta-aspartyl-peptidase activity','F','Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide.','2013-10-27','NSRP'),(6920,8800,'beta-lactamase activity','F','Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid.','2013-10-27','NSRP'),(6921,8801,'beta-phosphoglucomutase activity','F','Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate.','2013-10-27','NSRP'),(6922,8802,'betaine-aldehyde dehydrogenase activity','F','Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+.','2013-10-27','NSRP'),(6923,8803,'bis(5\'-nucleosyl)-tetraphosphatase (symmetrical) activity','F','Catalysis of the reaction: P(1),P(4)-bis(5\'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+).','2013-10-27','NSRP'),(6924,8804,'carbamate kinase activity','F','Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate.','2013-10-27','NSRP'),(6925,8805,'carbon-monoxide oxygenase activity','F','Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561.','2013-10-27','NSRP'),(6926,8806,'carboxymethylenebutenolidase activity','F','Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate.','2013-10-27','NSRP'),(6927,8807,'carboxyvinyl-carboxyphosphonate phosphorylmutase activity','F','Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2.','2013-10-27','NSRP'),(6928,8808,'cardiolipin synthase activity','F','Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol.','2013-10-27','NSRP'),(6929,8809,'carnitine racemase activity','F','Catalysis of the reaction: D-carnitine = L-carnitine.','2013-10-27','NSRP'),(6930,8810,'cellulase activity','F','Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.','2013-10-27','NSRP'),(6931,8811,'chloramphenicol O-acetyltransferase activity','F','Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA.','2013-10-27','NSRP'),(6932,8812,'choline dehydrogenase activity','F','Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde.','2013-10-27','NSRP'),(6933,8813,'chorismate lyase activity','F','Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate.','2013-10-27','NSRP'),(6934,8814,'citrate CoA-transferase activity','F','Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA.','2013-10-27','NSRP'),(6935,8815,'citrate (pro-3S)-lyase activity','F','Catalysis of the reaction: citrate = acetate + oxaloacetate.','2013-10-27','NSRP'),(6936,8816,'citryl-CoA lyase activity','F','Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate.','2013-10-27','NSRP'),(6937,8817,'cob(I)yrinic acid a,c-diamide adenosyltransferase activity','F','Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin.','2013-10-27','NSRP'),(6938,8818,'cobalamin 5\'-phosphate synthase activity','F','Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5\'-phosphate = adenosylcobalamin-5\'-phosphate + GMP.','2013-10-27','NSRP'),(6939,8819,'cobinamide kinase activity','F','Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate.','2013-10-27','NSRP'),(6940,8820,'cobinamide phosphate guanylyltransferase activity','F','Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H(+) = adenosylcobinamide-GDP + diphosphate.','2013-10-27','NSRP'),(6941,8821,'crossover junction endodeoxyribonuclease activity','F','Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).','2013-10-27','NSRP'),(6942,8822,'crotonobetaine/carnitine-CoA ligase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6943,8823,'cupric reductase activity','F','Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH.','2013-10-27','NSRP'),(6944,8824,'cyanate hydratase activity','F','Catalysis of the reaction: cyanate + H2O = carbamate.','2013-10-27','NSRP'),(6945,8825,'cyclopropane-fatty-acyl-phospholipid synthase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.','2013-10-27','NSRP'),(6946,8826,'cysteine sulfinate desulfinase activity','F','Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite.','2013-10-27','NSRP'),(6947,8827,'cytochrome o ubiquinol oxidase activity','F','Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2O; cytochrome O is the electron acceptor.','2013-10-27','NSRP'),(6948,8828,'dATP pyrophosphohydrolase activity','F','Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate.','2013-10-27','NSRP'),(6949,8829,'dCTP deaminase activity','F','Catalysis of the reaction: dCTP + H2O = dUTP + NH3.','2013-10-27','NSRP'),(6950,8830,'dTDP-4-dehydrorhamnose 3,5-epimerase activity','F','Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose.','2013-10-27','NSRP'),(6951,8831,'dTDP-4-dehydrorhamnose reductase activity','F','Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH.','2013-10-27','NSRP'),(6952,8832,'dGTPase activity','F','Catalysis of the reaction: dGTP + H(2)O = 2\'-deoxyguanosine + 2 H(+) + triphosphate.','2013-10-27','NSRP'),(6953,8833,'deoxyribonuclease IV (phage-T4-induced) activity','F','Catalysis of the endonucleolytic cleavage to 5\'-phosphooligonucleotide end-products.','2013-10-27','NSRP'),(6954,8834,'di-trans,poly-cis-decaprenylcistransferase activity','F','Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate.','2013-10-27','NSRP'),(6955,8835,'diaminohydroxyphosphoribosylaminopyrimidine deaminase activity','F','Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+).','2013-10-27','NSRP'),(6956,8836,'diaminopimelate decarboxylase activity','F','Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2).','2013-10-27','NSRP'),(6957,8837,'diaminopimelate epimerase activity','F','Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate.','2013-10-27','NSRP'),(6958,8838,'diaminopropionate ammonia-lyase activity','F','Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3.','2013-10-27','NSRP'),(6959,8839,'4-hydroxy-tetrahydrodipicolinate reductase','F','Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+.','2013-10-27','NSRP'),(6960,8840,'4-hydroxy-tetrahydrodipicolinate synthase','F','Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O.','2013-10-27','NSRP'),(6961,8841,'dihydrofolate synthase activity','F','Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate.','2013-10-27','NSRP'),(6962,8842,'diphosphate-purine nucleoside kinase activity','F','Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide.','2013-10-27','NSRP'),(6963,8843,'endochitinase activity','F','Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain.','2013-10-27','NSRP'),(6964,8845,'endonuclease VIII activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6965,8846,'endopeptidase La activity','F','OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP.','2013-10-27','NSRP'),(6966,8847,'Enterobacter ribonuclease activity','F','Catalysis of the endonucleolytic cleavage to 3\'-phosphomononucleotides and 3\'-phosphooligonucleotides with 2\',3\'-cyclic phosphate intermediates.','2013-10-27','NSRP'),(6967,8848,'enterobactin synthetase','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(6968,8849,'enterochelin esterase activity','F','Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+.','2013-10-27','NSRP'),(6969,8851,'ethanolamine ammonia-lyase activity','F','Catalysis of the reaction: ethanolamine = acetaldehyde + NH3.','2013-10-27','NSRP'),(6970,8852,'exodeoxyribonuclease I activity','F','Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3\' to 5\' direction, releasing 5\'-phosphomononucleotides.','2013-10-27','NSRP'),(6971,8853,'exodeoxyribonuclease III activity','F','Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3\' to 5\' direction, releasing 5\'-phosphomononucleotides.','2013-10-27','NSRP'),(6972,8854,'exodeoxyribonuclease V activity','F','Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5\' to 3\' or 3\' to 5\' direction to yield 5\'-phosphooligonucleotides.','2013-10-27','NSRP'),(6973,8855,'exodeoxyribonuclease VII activity','F','Catalysis of the exonucleolytic cleavage in either 5\' to 3\' or 3\' to 5\' direction to yield 5\'-phosphomononucleotides.','2013-10-27','NSRP'),(6974,8856,'exodeoxyribonuclease X activity','F','Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes.','2013-10-27','NSRP'),(6975,8859,'exoribonuclease II activity','F','Catalysis of the reaction: RNA + H2O = 5\'-phosphomononucleotides. Cleaves RNA in the 3\' to 5\' direction.','2013-10-27','NSRP'),(6976,8860,'ferredoxin-NAD+ reductase activity','F','Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+.','2013-10-27','NSRP'),(6977,8861,'formate C-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate.','2013-10-27','NSRP'),(6978,8863,'formate dehydrogenase (NAD+) activity','F','Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH.','2013-10-27','NSRP'),(6979,8864,'formyltetrahydrofolate deformylase activity','F','Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+).','2013-10-27','NSRP'),(6980,8865,'fructokinase activity','F','Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate.','2013-10-27','NSRP'),(6981,8866,'fructuronate reductase activity','F','Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH.','2013-10-27','NSRP'),(6982,8867,'galactarate dehydratase activity','F','Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O.','2013-10-27','NSRP'),(6983,8868,'galactitol-1-phosphate 5-dehydrogenase activity','F','Catalysis of the reaction: galactitol-1-phosphate + NAD+ = L-tagatose 6-phosphate + NADH + H+.','2013-10-27','NSRP'),(6984,8869,'galactonate dehydratase activity','F','Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O.','2013-10-27','NSRP'),(6985,8870,'galactoside O-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside.','2013-10-27','NSRP'),(6986,8871,'aminoglycoside 2\'\'-nucleotidyltransferase activity','F','Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2\'\'-nucleotidylaminoglycoside.','2013-10-27','NSRP'),(6987,8872,'glucarate dehydratase activity','F','Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O.','2013-10-27','NSRP'),(6988,8873,'gluconate 2-dehydrogenase activity','F','Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+.','2013-10-27','NSRP'),(6989,8874,'gluconate 5-dehydrogenase activity','F','Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+.','2013-10-27','NSRP'),(6990,8875,'gluconate dehydrogenase activity','F','Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+.','2013-10-27','NSRP'),(6991,8876,'quinoprotein glucose dehydrogenase activity','F','Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol.','2013-10-27','NSRP'),(6992,8877,'glucose-1-phosphatase activity','F','Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate.','2013-10-27','NSRP'),(6993,8878,'glucose-1-phosphate adenylyltransferase activity','F','Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate.','2013-10-27','NSRP'),(6994,8879,'glucose-1-phosphate thymidylyltransferase activity','F','Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose.','2013-10-27','NSRP'),(6995,8880,'glucuronate isomerase activity','F','Catalysis of the reaction: D-glucuronate = D-fructuronate.','2013-10-27','NSRP'),(6996,8881,'glutamate racemase activity','F','Catalysis of the reaction: L-glutamate = D-glutamate.','2013-10-27','NSRP'),(6997,8882,'[glutamate-ammonia-ligase] adenylyltransferase activity','F','Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].','2013-10-27','NSRP'),(6998,8883,'glutamyl-tRNA reductase activity','F','Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH.','2013-10-27','NSRP'),(6999,8884,'glutathionylspermidine amidase activity','F','Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine.','2013-10-27','NSRP'),(7000,8885,'glutathionylspermidine synthase activity','F','Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate.','2013-10-27','NSRP'),(7001,8886,'glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity','F','Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(2)O + NADP(+) = 3-phospho-D-glycerate + 2 H(+) + NADPH.','2013-10-27','NSRP'),(7002,8887,'glycerate kinase activity','F','Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+).','2013-10-27','NSRP'),(7003,8888,'glycerol dehydrogenase [NAD+] activity','F','Catalysis of the reaction: glycerol + NAD(+) = glycerone + H(+) + NADH.','2013-10-27','NSRP'),(7004,8889,'glycerophosphodiester phosphodiesterase activity','F','Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate.','2013-10-27','NSRP'),(7005,8890,'glycine C-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+).','2013-10-27','NSRP'),(7006,8891,'glycolate oxidase activity','F','Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide.','2013-10-27','NSRP'),(7007,8892,'guanine deaminase activity','F','Catalysis of the reaction: guanine + H2O = xanthine + NH3.','2013-10-27','NSRP'),(7008,8893,'guanosine-3\',5\'-bis(diphosphate) 3\'-diphosphatase activity','F','Catalysis of the reaction: guanosine 3\',5\'-bis(diphosphate) + H2O = guanosine 5\'-diphosphate + diphosphate.','2013-10-27','NSRP'),(7009,8894,'guanosine-5\'-triphosphate,3\'-diphosphate diphosphatase activity','F','Catalysis of the reaction: guanosine 5\'-triphosphate,3\'-diphosphate + H2O = guanosine 5\'-diphosphate,3\'-diphosphate + phosphate.','2013-10-27','NSRP'),(7010,8897,'holo-[acyl-carrier-protein] synthase activity','F','Catalysis of the reaction: CoA + substrate-serine = adenosine 3\',5\'-bisphosphate + substrate-serine-4\'-phosphopantetheine. The transfer of the 4\'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.','2013-10-27','NSRP'),(7011,8898,'homocysteine S-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine.','2013-10-27','NSRP'),(7012,8899,'homoserine O-succinyltransferase activity','F','Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA.','2013-10-27','NSRP'),(7013,8900,'hydrogen:potassium-exchanging ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in).','2013-10-27','NSRP'),(7014,8901,'ferredoxin hydrogenase activity','F','Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2.','2013-10-27','NSRP'),(7015,8902,'hydroxymethylpyrimidine kinase activity','F','Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H(+).','2013-10-27','NSRP'),(7016,8903,'hydroxypyruvate isomerase activity','F','Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate.','2013-10-27','NSRP'),(7017,8904,'hygromycin-B 7\'\'-O-phosphotransferase activity','F','Catalysis of the reaction: ATP + hygromycin B = 7\'\'-O-phosphohygromycin B + ADP + 2 H(+).','2013-10-27','NSRP'),(7018,8905,'mannose-phosphate guanylyltransferase activity','F','Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule.','2013-10-27','NSRP'),(7019,8906,'inosine kinase activity','F','Catalysis of the reaction: ATP + inosine = ADP + IMP.','2013-10-27','NSRP'),(7020,8907,'integrase activity','F','Catalysis of the integration of one segment of DNA into another.','2013-10-27','NSRP'),(7021,8908,'isochorismatase activity','F','Catalysis of the reaction: H(2)O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate.','2013-10-27','NSRP'),(7022,8909,'isochorismate synthase activity','F','Catalysis of the reaction: chorismate = isochorismate.','2013-10-27','NSRP'),(7023,8910,'kanamycin kinase activity','F','Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3\'-phosphate.','2013-10-27','NSRP'),(7024,8911,'lactaldehyde dehydrogenase activity','F','Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+.','2013-10-27','NSRP'),(7025,8912,'lactaldehyde reductase activity','F','Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+.','2013-10-27','NSRP'),(7026,8913,'lauroyltransferase activity','F','Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another.','2013-10-27','NSRP'),(7027,8914,'leucyltransferase activity','F','Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein.','2013-10-27','NSRP'),(7028,8915,'lipid-A-disaccharide synthase activity','F','Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H(+) + UDP.','2013-10-27','NSRP'),(7029,8917,'lipopolysaccharide N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide.','2013-10-27','NSRP'),(7030,8918,'lipopolysaccharide 3-alpha-galactosyltransferase activity','F','Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide.','2013-10-27','NSRP'),(7031,8919,'lipopolysaccharide glucosyltransferase I activity','F','Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide.','2013-10-27','NSRP'),(7032,8920,'lipopolysaccharide heptosyltransferase activity','F','Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+.','2013-10-27','NSRP'),(7033,8921,'lipopolysaccharide-1,6-galactosyltransferase activity','F','Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide.','2013-10-27','NSRP'),(7034,8922,'long-chain fatty acid [acyl-carrier-protein] ligase activity','F','Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22.','2013-10-27','NSRP'),(7035,8923,'lysine decarboxylase activity','F','Catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2).','2013-10-27','NSRP'),(7036,8924,'malate dehydrogenase (quinone) activity','F','Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol.','2013-10-27','NSRP'),(7037,8925,'maltose O-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose.','2013-10-27','NSRP'),(7038,8926,'mannitol-1-phosphate 5-dehydrogenase activity','F','Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+.','2013-10-27','NSRP'),(7039,8927,'mannonate dehydratase activity','F','Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O.','2013-10-27','NSRP'),(7040,8928,'mannose-1-phosphate guanylyltransferase (GDP) activity','F','Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate.','2013-10-27','NSRP'),(7041,8929,'methylglyoxal synthase activity','F','Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate.','2013-10-27','NSRP'),(7042,8930,'methylthioadenosine nucleosidase activity','F','Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose.','2013-10-27','NSRP'),(7043,8931,'murein DD-endopeptidase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7044,8932,'lytic endotransglycosylase activity','F','Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends.','2013-10-27','NSRP'),(7045,8933,'lytic transglycosylase activity','F','Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues.','2013-10-27','NSRP'),(7046,8934,'inositol monophosphate 1-phosphatase activity','F','Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate.','2013-10-27','NSRP'),(7047,8935,'1,4-dihydroxy-2-naphthoyl-CoA synthase activity','F','Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA.','2013-10-27','NSRP'),(7048,8936,'nicotinamidase activity','F','Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3.','2013-10-27','NSRP'),(7049,8937,'ferredoxin-NAD(P) reductase activity','F','Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+.','2013-10-27','NSRP'),(7050,8938,'nicotinate N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(7051,8939,'nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity','F','Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5\'-phosphate + H(+) + nicotinate.','2013-10-27','NSRP'),(7052,8940,'nitrate reductase activity','F','Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor.','2013-10-27','NSRP'),(7053,8941,'nitric oxide dioxygenase activity','F','Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+.','2013-10-27','NSRP'),(7054,8942,'nitrite reductase [NAD(P)H] activity','F','Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+.','2013-10-27','NSRP'),(7055,8943,'glyceraldehyde-3-phosphate dehydrogenase activity','F','OBSOLETE. Catalysis of the reactions: glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl-phosphate + NAD(P)H + H+, and glyceraldehyde 3-phosphate + H2O + NAD(P)+ = 3-phospho-D-glycerate + NAD(P)H + H+.','2013-10-27','NSRP'),(7056,8944,'oligopeptidase A activity','F','OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1\' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5.','2013-10-27','NSRP'),(7057,8945,'oligopeptidase B activity','F','OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1\' residue is proline.','2013-10-27','NSRP'),(7058,8946,'oligonucleotidase activity','F','Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5\'-phosphates.','2013-10-27','NSRP'),(7059,8947,'omptin activity','F','OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys.','2013-10-27','NSRP'),(7060,8948,'oxaloacetate decarboxylase activity','F','Catalysis of the reaction: oxaloacetate = pyruvate + CO2.','2013-10-27','NSRP'),(7061,8949,'oxalyl-CoA decarboxylase activity','F','Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA.','2013-10-27','NSRP'),(7062,8950,'p-aminobenzoate synthetase','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7063,8951,'palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity','F','Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein].','2013-10-27','NSRP'),(7064,8953,'penicillin amidase activity','F','Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate.','2013-10-27','NSRP'),(7065,8954,'peptidoglycan synthetase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7066,8955,'peptidoglycan glycosyltransferase activity','F','Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.','2013-10-27','NSRP'),(7067,8956,'peptidyl-dipeptidase Dcp activity','F','OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1\' is Pro, or both P1 and P1\' are Gly.','2013-10-27','NSRP'),(7068,8957,'phenylacetaldehyde dehydrogenase activity','F','Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+.','2013-10-27','NSRP'),(7069,8959,'phosphate acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate.','2013-10-27','NSRP'),(7070,8960,'phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity','F','Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose.','2013-10-27','NSRP'),(7071,8961,'phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity','F','Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein.','2013-10-27','NSRP'),(7072,8962,'phosphatidylglycerophosphatase activity','F','Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.','2013-10-27','NSRP'),(7073,8963,'phospho-N-acetylmuramoyl-pentapeptide-transferase activity','F','Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol.','2013-10-27','NSRP'),(7074,8964,'phosphoenolpyruvate carboxylase activity','F','Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-.','2013-10-27','NSRP'),(7075,8965,'phosphoenolpyruvate-protein phosphotransferase activity','F','Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine.','2013-10-27','NSRP'),(7076,8966,'phosphoglucosamine mutase activity','F','Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.','2013-10-27','NSRP'),(7077,8967,'phosphoglycolate phosphatase activity','F','Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate.','2013-10-27','NSRP'),(7078,8968,'D-sedoheptulose 7-phosphate isomerase activity','F','Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate.','2013-10-27','NSRP'),(7079,8969,'phosphohistidine phosphatase activity','F','Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate.','2013-10-27','NSRP'),(7080,8970,'phosphatidylcholine 1-acylhydrolase activity','F','Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate.','2013-10-27','NSRP'),(7081,8972,'phosphomethylpyrimidine kinase activity','F','Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine.','2013-10-27','NSRP'),(7082,8973,'phosphopentomutase activity','F','Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate.','2013-10-27','NSRP'),(7083,8974,'phosphoribulokinase activity','F','Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(7084,8975,'pitrilysin activity','F','OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon.','2013-10-27','NSRP'),(7085,8976,'polyphosphate kinase activity','F','Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1).','2013-10-27','NSRP'),(7086,8977,'prephenate dehydrogenase activity','F','Catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH.','2013-10-27','NSRP'),(7087,8978,'prepilin peptidase activity','F','OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.','2013-10-27','NSRP'),(7088,8979,'prophage integrase activity','F','Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome.','2013-10-27','NSRP'),(7089,8980,'propionate kinase activity','F','Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate.','2013-10-27','NSRP'),(7090,8981,'protease IV activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7091,8982,'protein-N(PI)-phosphohistidine-sugar phosphotransferase activity','F','Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.','2013-10-27','NSRP'),(7092,8983,'protein-glutamate O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester.','2013-10-27','NSRP'),(7093,8984,'protein-glutamate methylesterase activity','F','Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol.','2013-10-27','NSRP'),(7094,8985,'pyruvate dehydrogenase (cytochrome) activity','F','OBSOLETE. Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1.','2013-10-27','NSRP'),(7095,8986,'pyruvate, water dikinase activity','F','Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate.','2013-10-27','NSRP'),(7096,8987,'quinolinate synthetase A activity','F','Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate.','2013-10-27','NSRP'),(7097,8988,'rRNA (adenine-N6-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine.','2013-10-27','NSRP'),(7098,8989,'rRNA (guanine-N1-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine.','2013-10-27','NSRP'),(7099,8990,'rRNA (guanine-N2-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine.','2013-10-27','NSRP'),(7100,8991,'serine-type signal peptidase activity','F','OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism.','2013-10-27','NSRP'),(7101,8992,'repressor LexA activity','F','OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA.','2013-10-27','NSRP'),(7102,8993,'rhamnulokinase activity','F','Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate.','2013-10-27','NSRP'),(7103,8994,'rhamnulose-1-phosphate aldolase activity','F','Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde.','2013-10-27','NSRP'),(7104,8995,'ribonuclease E activity','F','Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5\'-end; cleavage occurs predominantly at 5 nucleotides from the 5\'-end and in A + U-rich regions, and is blocked by the presence of a 5\'-triphosphate group.','2013-10-27','NSRP'),(7105,8996,'ribonuclease G activity','F','Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5\'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5\'-end and in A + U-rich regions, and is blocked by the presence of a 5\'-triphosphate group.','2013-10-27','NSRP'),(7106,8997,'ribonuclease R activity','F','Catalysis of the reaction: RNA + H2O = 5\'-phosphomononucleotides. Cleaves RNA in the 3\' to 5\' direction, leaving an undigested core of 3-5 nucleotides.','2013-10-27','NSRP'),(7107,8998,'ribonucleoside-triphosphate reductase activity','F','Catalysis of the reaction: 2\'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.','2013-10-27','NSRP'),(7108,8999,'ribosomal-protein-alanine N-acetyltransferase activity','F','Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine.','2013-10-27','NSRP'),(7109,9000,'selenocysteine lyase activity','F','Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor.','2013-10-27','NSRP'),(7110,9001,'serine O-acetyltransferase activity','F','Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA.','2013-10-27','NSRP'),(7111,9002,'serine-type D-Ala-D-Ala carboxypeptidase activity','F','Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.','2013-10-27','NSRP'),(7112,9003,'signal peptidase activity','F','OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor.','2013-10-27','NSRP'),(7113,9004,'signal peptidase I activity','F','OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor.','2013-10-27','NSRP'),(7114,9005,'signal peptidase II activity','F','OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group.','2013-10-27','NSRP'),(7115,9006,'siroheme synthase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7116,9007,'site-specific DNA-methyltransferase (adenine-specific) activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.','2013-10-27','NSRP'),(7117,9008,'DNA-methyltransferase activity','F','Catalysis of the transfer of a methyl group to a DNA molecule.','2013-10-27','NSRP'),(7118,9009,'site-specific recombinase activity','F','Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences.','2013-10-27','NSRP'),(7119,9010,'sorbitol-6-phosphate 2-dehydrogenase activity','F','Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+.','2013-10-27','NSRP'),(7120,9011,'starch synthase activity','F','Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1).','2013-10-27','NSRP'),(7121,9012,'aminoglycoside 3\'\'-adenylyltransferase activity','F','Catalysis of the reaction: ATP + streptomycin = 3\'\'-adenylylstreptomycin + diphosphate + H(+).','2013-10-27','NSRP'),(7122,9013,'succinate-semialdehyde dehydrogenase [NAD(P)+] activity','F','Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+.','2013-10-27','NSRP'),(7123,9014,'succinyl-diaminopimelate desuccinylase activity','F','Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate.','2013-10-27','NSRP'),(7124,9015,'N-succinylarginine dihydrolase activity','F','Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H(2)O + 2 H(+) = N(2)-succinyl-L-ornithine + CO(2) + 2 NH(4)(+).','2013-10-27','NSRP'),(7125,9016,'succinyldiaminopimelate transaminase activity','F','Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate.','2013-10-27','NSRP'),(7126,9017,'succinylglutamate desuccinylase activity','F','Catalysis of the reaction: N-succinyl-L-glutamate + H(2)O = L-glutamate + succinate.','2013-10-27','NSRP'),(7127,9018,'sucrose phosphorylase activity','F','Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate.','2013-10-27','NSRP'),(7128,9019,'tRNA (guanine-N1-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine.','2013-10-27','NSRP'),(7129,9020,'tRNA (guanosine-2\'-O-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2\'-O-methylguanosine.','2013-10-27','NSRP'),(7130,9021,'tRNA (uracil-5-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine.','2012-03-14','NSRP'),(7131,9022,'tRNA nucleotidyltransferase activity','F','Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate.','2013-10-27','NSRP'),(7132,9023,'tRNA sulfurtransferase','F','OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide.','2013-10-27','NSRP'),(7133,9024,'tagatose-6-phosphate kinase activity','F','Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate.','2013-10-27','NSRP'),(7134,9025,'tagatose-bisphosphate aldolase activity','F','Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate.','2013-10-27','NSRP'),(7135,9026,'tagaturonate reductase activity','F','Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH.','2013-10-27','NSRP'),(7136,9027,'tartrate dehydrogenase activity','F','Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+.','2013-10-27','NSRP'),(7137,9028,'tartronate-semialdehyde synthase activity','F','Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2).','2013-10-27','NSRP'),(7138,9029,'tetraacyldisaccharide 4\'-kinase activity','F','Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H(+) + lipid IV(a).','2013-10-27','NSRP'),(7139,9030,'thiamine-phosphate kinase activity','F','Catalysis of the reaction: ATP + thiamine phosphate = ADP + H(+) + thiamine diphosphate.','2013-10-27','NSRP'),(7140,9032,'thymidine phosphorylase activity','F','Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate.','2013-10-27','NSRP'),(7141,9033,'trimethylamine-N-oxide reductase activity','F','Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O.','2013-10-27','NSRP'),(7142,9034,'tryptophanase activity','F','Catalysis of the reaction: L-tryptophan + H(2)O = indole + NH(4)(+) + pyruvate.','2013-10-27','NSRP'),(7143,9035,'Type I site-specific deoxyribonuclease activity','F','Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5\' or 3\' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA.','2013-10-27','NSRP'),(7144,9036,'Type II site-specific deoxyribonuclease activity','F','Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5\'-phosphates and 3\' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site.','2013-10-27','NSRP'),(7145,9037,'tyrosine-based site-specific recombinase activity','F','Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site.','2013-10-27','NSRP'),(7146,9038,'undecaprenol kinase activity','F','Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate.','2013-10-27','NSRP'),(7147,9039,'urease activity','F','Catalysis of the reaction: urea + H2O = CO2 + 2 NH3.','2013-10-27','NSRP'),(7148,9040,'ureidoglycolate dehydrogenase activity','F','Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+.','2013-10-27','NSRP'),(7149,9041,'uridylate kinase activity','F','Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.','2013-10-27','NSRP'),(7150,9042,'valine-pyruvate transaminase activity','F','Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine.','2013-10-27','NSRP'),(7151,9044,'xylan 1,4-beta-xylosidase activity','F','Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini.','2013-10-27','NSRP'),(7152,9045,'xylose isomerase activity','F','Catalysis of the reaction: D-xylose = D-xylulose.','2013-10-27','NSRP'),(7153,9046,'zinc D-Ala-D-Ala carboxypeptidase activity','F','Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine.','2013-10-27','NSRP'),(7154,9047,'dosage compensation by hyperactivation of X chromosome','P','Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(7155,9048,'dosage compensation by inactivation of X chromosome','P','Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.','2013-10-27','NSRP'),(7156,9049,'aspartic-type signal peptidase activity','F','OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism.','2013-10-27','NSRP'),(7157,9050,'glycopeptide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glycopeptides, any compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide.','2013-10-27','NSRP'),(7158,9051,'pentose-phosphate shunt, oxidative branch','P','The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2).','2013-10-27','NSRP'),(7159,9052,'pentose-phosphate shunt, non-oxidative branch','P','The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P.','2013-10-27','NSRP'),(7160,9055,'electron carrier activity','F','Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.','2013-10-27','NSRP'),(7161,9056,'catabolic process','P','The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.','2013-10-27','NSRP'),(7162,9057,'macromolecule catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.','2013-10-27','NSRP'),(7163,9058,'biosynthetic process','P','The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.','2013-10-27','NSRP'),(7164,9059,'macromolecule biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.','2013-10-27','NSRP'),(7165,9060,'aerobic respiration','P','The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.','2013-10-27','NSRP'),(7166,9061,'anaerobic respiration','P','The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor.','2013-10-27','NSRP'),(7167,9062,'fatty acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.','2013-10-27','NSRP'),(7168,9063,'cellular amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.','2013-10-27','NSRP'),(7169,9064,'glutamine family amino acid metabolic process','P','The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.','2013-10-27','NSRP'),(7170,9065,'glutamine family amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.','2013-10-27','NSRP'),(7171,9066,'aspartate family amino acid metabolic process','P','The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.','2013-10-27','NSRP'),(7172,9067,'aspartate family amino acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.','2013-10-27','NSRP'),(7173,9068,'aspartate family amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.','2013-10-27','NSRP'),(7174,9069,'serine family amino acid metabolic process','P','The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.','2013-10-27','NSRP'),(7175,9070,'serine family amino acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.','2013-10-27','NSRP'),(7176,9071,'serine family amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.','2013-10-27','NSRP'),(7177,9072,'aromatic amino acid family metabolic process','P','The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).','2013-10-27','NSRP'),(7178,9073,'aromatic amino acid family biosynthetic process','P','The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).','2013-10-27','NSRP'),(7179,9074,'aromatic amino acid family catabolic process','P','The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).','2013-10-27','NSRP'),(7180,9075,'histidine family amino acid metabolic process','P','OBSOLETE. The chemical reactions and pathways involving amino acids of the histidine family.','2013-10-27','NSRP'),(7181,9076,'histidine family amino acid biosynthetic process','P','OBSOLETE. The chemical reactions and pathways resulting in the formation of amino acids of the histidine family.','2013-10-27','NSRP'),(7182,9077,'histidine family amino acid catabolic process','P','OBSOLETE. The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family.','2013-10-27','NSRP'),(7183,9078,'pyruvate family amino acid metabolic process','P','The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine.','2013-10-27','NSRP'),(7184,9079,'pyruvate family amino acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine.','2013-10-27','NSRP'),(7185,9080,'pyruvate family amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine.','2013-10-27','NSRP'),(7186,9081,'branched-chain amino acid metabolic process','P','The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.','2013-10-27','NSRP'),(7187,9082,'branched-chain amino acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.','2013-10-27','NSRP'),(7188,9083,'branched-chain amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.','2013-10-27','NSRP'),(7189,9084,'glutamine family amino acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.','2013-10-27','NSRP'),(7190,9085,'lysine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid.','2013-10-27','NSRP'),(7191,9086,'methionine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.','2013-10-27','NSRP'),(7192,9087,'methionine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.','2013-10-27','NSRP'),(7193,9088,'threonine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.','2013-10-27','NSRP'),(7194,9089,'lysine biosynthetic process via diaminopimelate','P','The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate.','2013-10-27','NSRP'),(7195,9090,'homoserine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid.','2013-10-27','NSRP'),(7196,9091,'homoserine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid.','2013-10-27','NSRP'),(7197,9092,'homoserine metabolic process','P','The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine.','2013-10-27','NSRP'),(7198,9093,'cysteine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid.','2013-10-27','NSRP'),(7199,9094,'L-phenylalanine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid.','2013-10-27','NSRP'),(7200,9095,'aromatic amino acid family biosynthetic process, prephenate pathway','P','The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate.','2013-10-27','NSRP'),(7201,9097,'isoleucine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.','2013-10-27','NSRP'),(7202,9098,'leucine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.','2013-10-27','NSRP'),(7203,9099,'valine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid.','2013-10-27','NSRP'),(7204,9100,'glycoprotein metabolic process','P','The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.','2013-10-27','NSRP'),(7205,9101,'glycoprotein biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.','2013-10-27','NSRP'),(7206,9102,'biotin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.','2013-10-27','NSRP'),(7207,9103,'lipopolysaccharide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.','2013-10-27','NSRP'),(7208,9104,'lipopolysaccharide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria.','2013-10-27','NSRP'),(7209,9106,'lipoate metabolic process','P','The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.','2013-10-27','NSRP'),(7210,9107,'lipoate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid.','2013-10-27','NSRP'),(7211,9108,'coenzyme biosynthetic process','P','The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.','2013-10-27','NSRP'),(7212,9109,'coenzyme catabolic process','P','The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed.','2013-10-27','NSRP'),(7213,9110,'vitamin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.','2013-10-27','NSRP'),(7214,9111,'vitamin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.','2013-10-27','NSRP'),(7215,9112,'nucleobase metabolic process','P','The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.','2013-10-27','NSRP'),(7216,9113,'purine nucleobase biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.','2013-10-27','NSRP'),(7217,9114,'hypoxanthine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate.','2013-10-27','NSRP'),(7218,9115,'xanthine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids.','2013-10-27','NSRP'),(7219,9116,'nucleoside metabolic process','P','The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine).','2013-10-27','NSRP'),(7220,9117,'nucleotide metabolic process','P','The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates).','2013-10-27','NSRP'),(7221,9118,'regulation of nucleoside metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides.','2013-10-27','NSRP'),(7222,9119,'ribonucleoside metabolic process','P','The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.','2013-10-27','NSRP'),(7223,9120,'deoxyribonucleoside metabolic process','P','The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside).','2013-10-27','NSRP'),(7224,9123,'nucleoside monophosphate metabolic process','P','The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7225,9124,'nucleoside monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7226,9125,'nucleoside monophosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7227,9126,'purine nucleoside monophosphate metabolic process','P','The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7228,9127,'purine nucleoside monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7229,9128,'purine nucleoside monophosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7230,9129,'pyrimidine nucleoside monophosphate metabolic process','P','The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7231,9130,'pyrimidine nucleoside monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7232,9131,'pyrimidine nucleoside monophosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7233,9132,'nucleoside diphosphate metabolic process','P','The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7234,9133,'nucleoside diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7235,9134,'nucleoside diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7236,9135,'purine nucleoside diphosphate metabolic process','P','The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7237,9136,'purine nucleoside diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7238,9137,'purine nucleoside diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7239,9138,'pyrimidine nucleoside diphosphate metabolic process','P','The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7240,9139,'pyrimidine nucleoside diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7241,9140,'pyrimidine nucleoside diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7242,9141,'nucleoside triphosphate metabolic process','P','The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7243,9142,'nucleoside triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7244,9143,'nucleoside triphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7245,9144,'purine nucleoside triphosphate metabolic process','P','The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7246,9145,'purine nucleoside triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7247,9146,'purine nucleoside triphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7248,9147,'pyrimidine nucleoside triphosphate metabolic process','P','The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7249,9148,'pyrimidine nucleoside triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7250,9149,'pyrimidine nucleoside triphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7251,9150,'purine ribonucleotide metabolic process','P','The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7252,9151,'purine deoxyribonucleotide metabolic process','P','The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7253,9152,'purine ribonucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7254,9153,'purine deoxyribonucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7255,9154,'purine ribonucleotide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7256,9155,'purine deoxyribonucleotide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7257,9156,'ribonucleoside monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7258,9157,'deoxyribonucleoside monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7259,9158,'ribonucleoside monophosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7260,9159,'deoxyribonucleoside monophosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7261,9161,'ribonucleoside monophosphate metabolic process','P','The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7262,9162,'deoxyribonucleoside monophosphate metabolic process','P','The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7263,9163,'nucleoside biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).','2013-10-27','NSRP'),(7264,9164,'nucleoside catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).','2013-10-27','NSRP'),(7265,9165,'nucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).','2013-10-27','NSRP'),(7266,9166,'nucleotide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates).','2013-10-27','NSRP'),(7267,9167,'purine ribonucleoside monophosphate metabolic process','P','The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7268,9168,'purine ribonucleoside monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7269,9169,'purine ribonucleoside monophosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7270,9170,'purine deoxyribonucleoside monophosphate metabolic process','P','The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7271,9171,'purine deoxyribonucleoside monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7272,9172,'purine deoxyribonucleoside monophosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7273,9173,'pyrimidine ribonucleoside monophosphate metabolic process','P','The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7274,9174,'pyrimidine ribonucleoside monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7275,9175,'pyrimidine ribonucleoside monophosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7276,9176,'pyrimidine deoxyribonucleoside monophosphate metabolic process','P','The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7277,9177,'pyrimidine deoxyribonucleoside monophosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7278,9178,'pyrimidine deoxyribonucleoside monophosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar.','2013-10-27','NSRP'),(7279,9179,'purine ribonucleoside diphosphate metabolic process','P','The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7280,9180,'purine ribonucleoside diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7281,9181,'purine ribonucleoside diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7282,9182,'purine deoxyribonucleoside diphosphate metabolic process','P','The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7283,9183,'purine deoxyribonucleoside diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7284,9184,'purine deoxyribonucleoside diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7285,9185,'ribonucleoside diphosphate metabolic process','P','The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7286,9186,'deoxyribonucleoside diphosphate metabolic process','P','The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7287,9187,'cyclic nucleotide metabolic process','P','The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.','2013-10-27','NSRP'),(7288,9188,'ribonucleoside diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7289,9189,'deoxyribonucleoside diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7290,9190,'cyclic nucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.','2013-10-27','NSRP'),(7291,9191,'ribonucleoside diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7292,9192,'deoxyribonucleoside diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7293,9193,'pyrimidine ribonucleoside diphosphate metabolic process','P','The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7294,9194,'pyrimidine ribonucleoside diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7295,9195,'pyrimidine ribonucleoside diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7296,9196,'pyrimidine deoxyribonucleoside diphosphate metabolic process','P','The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7297,9197,'pyrimidine deoxyribonucleoside diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7298,9198,'pyrimidine deoxyribonucleoside diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar.','2013-10-27','NSRP'),(7299,9199,'ribonucleoside triphosphate metabolic process','P','The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7300,9200,'deoxyribonucleoside triphosphate metabolic process','P','The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7301,9201,'ribonucleoside triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7302,9202,'deoxyribonucleoside triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7303,9203,'ribonucleoside triphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7304,9204,'deoxyribonucleoside triphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7305,9205,'purine ribonucleoside triphosphate metabolic process','P','The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7306,9206,'purine ribonucleoside triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7307,9207,'purine ribonucleoside triphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7308,9208,'pyrimidine ribonucleoside triphosphate metabolic process','P','The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7309,9209,'pyrimidine ribonucleoside triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7310,9210,'pyrimidine ribonucleoside triphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7311,9211,'pyrimidine deoxyribonucleoside triphosphate metabolic process','P','The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7312,9212,'pyrimidine deoxyribonucleoside triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7313,9213,'pyrimidine deoxyribonucleoside triphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7314,9214,'cyclic nucleotide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.','2013-10-27','NSRP'),(7315,9215,'purine deoxyribonucleoside triphosphate metabolic process','P','The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7316,9216,'purine deoxyribonucleoside triphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7317,9217,'purine deoxyribonucleoside triphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(7318,9218,'pyrimidine ribonucleotide metabolic process','P','The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7319,9219,'pyrimidine deoxyribonucleotide metabolic process','P','The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7320,9220,'pyrimidine ribonucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7321,9221,'pyrimidine deoxyribonucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7322,9222,'pyrimidine ribonucleotide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7323,9223,'pyrimidine deoxyribonucleotide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7324,9224,'CMP biosynthetic process','P','The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate.','2013-10-27','NSRP'),(7325,9225,'nucleotide-sugar metabolic process','P','The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5\'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.','2013-10-27','NSRP'),(7326,9226,'nucleotide-sugar biosynthetic process','P','The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5\'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.','2013-10-27','NSRP'),(7327,9227,'nucleotide-sugar catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5\'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.','2013-10-27','NSRP'),(7328,9228,'thiamine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.','2013-10-27','NSRP'),(7329,9229,'thiamine diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.','2013-10-27','NSRP'),(7330,9230,'thiamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.','2013-10-27','NSRP'),(7331,9231,'riboflavin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).','2013-10-27','NSRP'),(7332,9232,'riboflavin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).','2013-10-27','NSRP'),(7333,9233,'menaquinone metabolic process','P','The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.','2013-10-27','NSRP'),(7334,9234,'menaquinone biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.','2013-10-27','NSRP'),(7335,9235,'cobalamin metabolic process','P','The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.','2013-10-27','NSRP'),(7336,9236,'cobalamin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.','2013-10-27','NSRP'),(7337,9237,'siderophore metabolic process','P','The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.','2013-10-27','NSRP'),(7338,9238,'enterobactin metabolic process','P','The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N\',N\',N\'\'-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway.','2013-10-27','NSRP'),(7339,9239,'enterobactin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N\',N\',N\'\'-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway.','2013-10-27','NSRP'),(7340,9240,'isopentenyl diphosphate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids.','2013-10-27','NSRP'),(7341,9242,'colanic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide.','2013-10-27','NSRP'),(7342,9243,'O antigen biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.','2013-10-27','NSRP'),(7343,9244,'lipopolysaccharide core region biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.','2013-10-27','NSRP'),(7344,9245,'lipid A biosynthetic process','P','The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues.','2013-10-27','NSRP'),(7345,9246,'enterobacterial common antigen biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria.','2013-10-27','NSRP'),(7346,9247,'glycolipid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide).','2013-10-27','NSRP'),(7347,9248,'K antigen biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens.','2013-10-27','NSRP'),(7348,9249,'protein lipoylation','P','The addition of a lipoyl group to an amino acid residue in a protein.','2013-10-27','NSRP'),(7349,9250,'glucan biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.','2013-10-27','NSRP'),(7350,9251,'glucan catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues.','2013-10-27','NSRP'),(7351,9252,'peptidoglycan biosynthetic process','P','The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.','2013-10-27','NSRP'),(7352,9253,'peptidoglycan catabolic process','P','The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.','2013-10-27','NSRP'),(7353,9254,'peptidoglycan turnover','P','The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall.','2013-10-27','NSRP'),(7354,9255,'Entner-Doudoroff pathway','P','A pathway that converts glucose to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it.','2013-10-27','NSRP'),(7355,9256,'10-formyltetrahydrofolate metabolic process','P','The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.','2013-10-27','NSRP'),(7356,9257,'10-formyltetrahydrofolate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.','2013-10-27','NSRP'),(7357,9258,'10-formyltetrahydrofolate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate.','2013-10-27','NSRP'),(7358,9259,'ribonucleotide metabolic process','P','The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7359,9260,'ribonucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7360,9261,'ribonucleotide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7361,9262,'deoxyribonucleotide metabolic process','P','The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7362,9263,'deoxyribonucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7363,9264,'deoxyribonucleotide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7364,9265,'2\'-deoxyribonucleotide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a 2\'-deoxyribonucleotide, a compound consisting of 2\'-deoxyribonucleoside (a base linked to a 2\'-deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7365,9266,'response to temperature stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus.','2013-10-27','NSRP'),(7366,9267,'cellular response to starvation','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.','2013-10-27','NSRP'),(7367,9268,'response to pH','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus.','2013-10-27','NSRP'),(7368,9269,'response to desiccation','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water.','2013-10-27','NSRP'),(7369,9270,'response to humidity','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere.','2013-10-27','NSRP'),(7370,9271,'phage shock','P','A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage.','2013-10-27','NSRP'),(7371,9272,'fungal-type cell wall biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin.','2013-10-27','NSRP'),(7372,9273,'peptidoglycan-based cell wall biogenesis','P','The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli.','2013-10-27','NSRP'),(7373,9274,'peptidoglycan-based cell wall','C','A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.','2013-10-27','NSRP'),(7374,9275,'Gram-positive-bacterium-type cell wall','C','A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria.','2013-10-27','NSRP'),(7375,9276,'Gram-negative-bacterium-type cell wall','C','The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain.','2013-10-27','NSRP'),(7376,9277,'fungal-type cell wall','C','A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure.','2013-10-27','NSRP'),(7377,9278,'murein sacculus','C','OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria.','2013-10-27','NSRP'),(7378,9279,'cell outer membrane','C','A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.','2013-10-27','NSRP'),(7379,9280,'cell wall inner membrane','C','OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus.','2013-10-27','NSRP'),(7380,9288,'bacterial-type flagellum','C','A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope.','2013-10-27','NSRP'),(7381,9289,'pilus','C','A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.','2013-10-27','NSRP'),(7382,9290,'DNA import into cell involved in transformation','P','The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell.','2013-10-27','NSRP'),(7383,9291,'unidirectional conjugation','P','The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell (\'male\') is then transferred into the other cell (\'female\'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in Prokaryotes.','2013-10-27','NSRP'),(7384,9292,'genetic transfer','P','In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual.','2013-10-27','NSRP'),(7385,9293,'transduction','P','The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector.','2013-10-27','NSRP'),(7386,9294,'DNA mediated transformation','P','The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material.','2013-10-27','NSRP'),(7387,9295,'nucleoid','C','The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.','2013-10-27','NSRP'),(7388,9296,'flagellum assembly','P','The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers.','2013-10-27','NSRP'),(7389,9297,'pilus assembly','P','The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.','2013-10-27','NSRP'),(7390,9298,'GDP-mannose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.','2013-10-27','NSRP'),(7391,9299,'mRNA transcription','P','The cellular synthesis of messenger RNA (mRNA) from a DNA template.','2013-10-27','NSRP'),(7392,9300,'antisense RNA transcription','P','The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA.','2013-10-27','NSRP'),(7393,9301,'snRNA transcription','P','The synthesis of small nuclear RNA (snRNA) from a DNA template.','2013-10-27','NSRP'),(7394,9302,'snoRNA transcription','P','The synthesis of small nucleolar RNA (snoRNA) from a DNA template.','2013-10-27','NSRP'),(7395,9303,'rRNA transcription','P','The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template.','2013-10-27','NSRP'),(7396,9304,'tRNA transcription','P','The synthesis of transfer RNA (tRNA) from a DNA template.','2013-10-27','NSRP'),(7397,9305,'protein biotinylation','P','The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid.','2013-10-27','NSRP'),(7398,9306,'protein secretion','P','The controlled release of proteins from a cell.','2013-10-27','NSRP'),(7399,9307,'DNA restriction-modification system','P','A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism\'s own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme.','2013-10-27','NSRP'),(7400,9308,'amine metabolic process','P','The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.','2013-10-27','NSRP'),(7401,9309,'amine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.','2013-10-27','NSRP'),(7402,9310,'amine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.','2013-10-27','NSRP'),(7403,9311,'oligosaccharide metabolic process','P','The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.','2013-10-27','NSRP'),(7404,9312,'oligosaccharide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.','2013-10-27','NSRP'),(7405,9313,'oligosaccharide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages.','2013-10-27','NSRP'),(7406,9314,'response to radiation','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.','2013-10-27','NSRP'),(7407,9315,'drug resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7408,9316,'3-isopropylmalate dehydratase complex','C','A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.','2013-10-27','NSRP'),(7409,9317,'acetyl-CoA carboxylase complex','C','A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex.','2013-10-27','NSRP'),(7410,9318,'exodeoxyribonuclease VII complex','C','An enzyme complex that catalyzes exonucleolytic cleavage in either 5\' to 3\' or 3\' to 5\' direction to yield nucleoside 5\'-phosphates; it prefers single-stranded DNA.','2013-10-27','NSRP'),(7411,9319,'cytochrome o ubiquinol oxidase complex','C','A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups.','2013-10-27','NSRP'),(7412,9320,'phosphoribosylaminoimidazole carboxylase complex','C','A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity.','2013-10-27','NSRP'),(7413,9321,'alkyl hydroperoxide reductase complex','C','An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides.','2013-10-27','NSRP'),(7414,9322,'trimethylamine-N-oxide reductase complex','C','An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine.','2013-10-27','NSRP'),(7415,9323,'ribosomal-protein-alanine N-acetyltransferase complex','C','An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine.','2013-10-27','NSRP'),(7416,9324,'D-amino-acid dehydrogenase complex','C','A protein complex that possesses D-amino-acid dehydrogenase activity.','2013-10-27','NSRP'),(7417,9325,'nitrate reductase complex','C','An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor.','2013-10-27','NSRP'),(7418,9326,'formate dehydrogenase complex','C','An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2).','2013-10-27','NSRP'),(7419,9327,'NAD(P)+ transhydrogenase complex (AB-specific)','C','A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified.','2013-10-27','NSRP'),(7420,9328,'phenylalanine-tRNA ligase complex','C','An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe).','2013-10-27','NSRP'),(7421,9329,'acetate CoA-transferase complex','C','A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA.','2013-10-27','NSRP'),(7422,9330,'DNA topoisomerase complex (ATP-hydrolyzing)','C','Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity.','2013-10-27','NSRP'),(7423,9331,'glycerol-3-phosphate dehydrogenase complex','C','An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate.','2013-10-27','NSRP'),(7424,9332,'glutamate-tRNA ligase complex','C','An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu).','2013-10-27','NSRP'),(7425,9333,'cysteine synthase complex','C','Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A.','2013-10-27','NSRP'),(7426,9334,'3-phenylpropionate dioxygenase complex','C','Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol).','2013-10-27','NSRP'),(7427,9335,'holo-[acyl-carrier protein] synthase complex','C','OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein].','2013-10-27','NSRP'),(7428,9336,'sulfate adenylyltransferase complex (ATP)','C','An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP.','2013-10-27','NSRP'),(7429,9337,'sulfite reductase complex (NADPH)','C','A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide.','2013-10-27','NSRP'),(7430,9338,'exodeoxyribonuclease V complex','C','An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5\' to 3\' or 3\' to 5\' direction to yield 5\'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA.','2013-10-27','NSRP'),(7431,9339,'glycolate oxidase complex','C','An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN).','2013-10-27','NSRP'),(7432,9340,'DNA topoisomerase IV complex','C','A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA.','2013-10-27','NSRP'),(7433,9341,'beta-galactosidase complex','C','A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species.','2013-10-27','NSRP'),(7434,9342,'glutamate synthase complex (NADPH)','C','A complex that possesses glutamate synthase (NADPH) activity.','2013-10-27','NSRP'),(7435,9343,'biotin carboxylase complex','C','An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2).','2013-10-27','NSRP'),(7436,9344,'nitrite reductase complex [NAD(P)H]','C','Complex that possesses nitrite reductase [NAD(P)H] activity.','2013-10-27','NSRP'),(7437,9345,'glycine-tRNA ligase complex','C','A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly).','2013-10-27','NSRP'),(7438,9346,'citrate lyase complex','C','Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity.','2013-10-27','NSRP'),(7439,9347,'aspartate carbamoyltransferase complex','C','A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides.','2013-10-27','NSRP'),(7440,9348,'ornithine carbamoyltransferase complex','C','A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline.','2013-10-27','NSRP'),(7441,9349,'riboflavin synthase complex','C','An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine.','2013-10-27','NSRP'),(7442,9350,'ethanolamine ammonia-lyase complex','C','An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia.','2013-10-27','NSRP'),(7443,9351,'dihydrolipoamide S-acyltransferase complex','C','OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide.','2013-10-27','NSRP'),(7444,9352,'dihydrolipoyl dehydrogenase complex','C','OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity.','2013-10-27','NSRP'),(7445,9353,'mitochondrial oxoglutarate dehydrogenase complex','C','A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus.','2013-10-27','NSRP'),(7446,9354,'dihydrolipoamide S-succinyltransferase complex','C','OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex.','2013-10-27','NSRP'),(7447,9355,'DNA polymerase V complex','C','A DNA polymerase complex that contains two UmuD\' and one UmuC subunits, and acts in translesion DNA synthesis.','2013-10-27','NSRP'),(7448,9356,'aminodeoxychorismate synthase complex','C','A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity.','2013-10-27','NSRP'),(7449,9357,'protein-N(PI)-phosphohistidine-sugar phosphotransferase complex','C','An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system.','2013-10-27','NSRP'),(7450,9358,'polyphosphate kinase complex','C','A protein complex that possesses polyphosphate kinase activity.','2013-10-27','NSRP'),(7451,9359,'Type II site-specific deoxyribonuclease complex','C','A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell.','2013-10-27','NSRP'),(7452,9360,'DNA polymerase III complex','C','The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3\'-5\' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork.','2013-10-27','NSRP'),(7453,9361,'succinate-CoA ligase complex (ADP-forming)','C','A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP.','2013-10-27','NSRP'),(7454,9365,'protein histidine kinase complex','C','A complex that possesses protein histidine kinase activity.','2013-10-27','NSRP'),(7455,9366,'enterobactin synthetase complex','C','A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway.','2013-10-27','NSRP'),(7456,9367,'prepilin peptidase complex','C','OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group.','2013-10-27','NSRP'),(7457,9368,'endopeptidase Clp complex','C','A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form.','2013-10-27','NSRP'),(7458,9371,'positive regulation of transcription by pheromones','P','Any process involving pheromones that activates or increases the rate of transcription.','2013-10-27','NSRP'),(7459,9372,'quorum sensing','P','The process in which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves.','2013-10-27','NSRP'),(7460,9373,'regulation of transcription by pheromones','P','Any process involving pheromones that modulates the frequency, rate or extent of transcription.','2013-10-27','NSRP'),(7461,9374,'biotin binding','F','Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions.','2013-10-27','NSRP'),(7462,9375,'ferredoxin hydrogenase complex','C','An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances.','2013-10-27','NSRP'),(7463,9376,'HslUV protease complex','C','A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other Clp family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, six identical subunits of both the ATPase, ClpY, and the protease, ClpQ, self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, form a dumbbell-shaped complex.','2013-10-27','NSRP'),(7464,9377,'HslUV protease activity','F','OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins.','2013-10-27','NSRP'),(7465,9378,'four-way junction helicase activity','F','Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions.','2013-10-27','NSRP'),(7466,9379,'Holliday junction helicase complex','C','A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA.','2013-10-27','NSRP'),(7467,9380,'excinuclease repair complex','C','Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and one B subunit bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between subunit B and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap.','2013-10-27','NSRP'),(7468,9381,'excinuclease ABC activity','F','Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind.','2013-10-27','NSRP'),(7469,9382,'imidazoleglycerol-phosphate synthase complex','C','Complex that possesses imidazoleglycerol-phosphate synthase activity.','2013-10-27','NSRP'),(7470,9383,'rRNA (cytosine-C5-)-methyltransferase activity','F','Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA.','2013-10-27','NSRP'),(7471,9384,'N-acylmannosamine kinase activity','F','Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate.','2013-10-27','NSRP'),(7472,9385,'N-acylmannosamine-6-phosphate 2-epimerase activity','F','Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate.','2013-10-27','NSRP'),(7473,9386,'translational attenuation','P','Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.','2013-10-27','NSRP'),(7474,9388,'antisense RNA','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7475,9389,'dimethyl sulfoxide reductase activity','F','Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O.','2013-10-27','NSRP'),(7476,9390,'dimethyl sulfoxide reductase complex','C','An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide.','2013-10-27','NSRP'),(7477,9392,'N-acetyl-anhydromuramoyl-L-alanine amidase activity','F','Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala.','2013-10-27','NSRP'),(7478,9394,'2\'-deoxyribonucleotide metabolic process','P','The chemical reactions and pathways involving a 2\'-deoxyribonucleotide, a compound consisting of 2\'-deoxyribonucleoside (a base linked to a 2\'-deoxyribose sugar) esterified with a phosphate group at either the 3\' or 5\'-hydroxyl group of the sugar.','2013-10-27','NSRP'),(7479,9395,'phospholipid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.','2013-10-27','NSRP'),(7480,9396,'folic acid-containing compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.','2013-10-27','NSRP'),(7481,9397,'folic acid-containing compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives.','2013-10-27','NSRP'),(7482,9398,'FMN biosynthetic process','P','The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5\'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase.','2013-10-27','NSRP'),(7483,9399,'nitrogen fixation','P','The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide.','2013-10-27','NSRP'),(7484,9400,'receptor signaling protein serine/threonine phosphatase activity','F','Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate.','2013-10-27','NSRP'),(7485,9401,'phosphoenolpyruvate-dependent sugar phosphotransferase system','P','The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.','2013-10-27','NSRP'),(7486,9402,'toxin resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7487,9403,'toxin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.','2013-10-27','NSRP'),(7488,9404,'toxin metabolic process','P','The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.','2013-10-27','NSRP'),(7489,9405,'pathogenesis','P','The set of specific processes that generate the ability of an organism to cause disease in another.','2013-10-27','NSRP'),(7490,9406,'virulence','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7491,9407,'toxin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.','2013-10-27','NSRP'),(7492,9408,'response to heat','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.','2013-10-27','NSRP'),(7493,9409,'response to cold','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.','2013-10-27','NSRP'),(7494,9410,'response to xenobiotic stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms.','2013-10-27','NSRP'),(7495,9411,'response to UV','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.','2013-10-27','NSRP'),(7496,9412,'response to heavy metal','P','OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn.','2013-10-27','NSRP'),(7497,9413,'response to flooding','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water.','2013-10-27','NSRP'),(7498,9414,'response to water deprivation','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.','2013-10-27','NSRP'),(7499,9415,'response to water stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water.','2013-10-27','NSRP'),(7500,9416,'response to light stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.','2013-10-27','NSRP'),(7501,9417,'fimbrin','C','OBSOLETE. A class of proteins that are the subunit components of fimbria.','2013-10-27','NSRP'),(7502,9418,'pilus shaft','C','The long, slender, mid section of a pilus.','2013-10-27','NSRP'),(7503,9419,'pilus tip','C','The pointed extremity furthest from the cell of a pilus.','2013-10-27','NSRP'),(7504,9420,'bacterial-type flagellum filament','C','The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7505,9421,'bacterial-type flagellum filament cap','C','The proteinaceous structure at the distal tip of the flagellar filament. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7506,9422,'bacterial-type flagellum hook-filament junction','C','The region of the flagellum where the hook and filament meet. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7507,9423,'chorismate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds.','2013-10-27','NSRP'),(7508,9424,'bacterial-type flagellum hook','C','The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7509,9425,'bacterial-type flagellum basal body','C','One of the three major substructures of the flagellin-based flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring). Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7510,9426,'bacterial-type flagellum basal body, distal rod','C','The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7511,9427,'bacterial-type flagellum basal body, distal rod, L ring','C','One of the rings of the flagellar basal body; anchors the basal body to the outer membrane. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7512,9428,'bacterial-type flagellum basal body, distal rod, P ring','C','One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7513,9429,'bacterial-type flagellum basal body, proximal rod','C','The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7514,9431,'bacterial-type flagellum basal body, MS ring','C','One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7515,9432,'SOS response','P','An error-prone process for repairing damaged microbial DNA.','2013-10-27','NSRP'),(7516,9433,'bacterial-type flagellum basal body, C ring','C','Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. Examples of this component are found in bacteria.','2013-10-27','NSRP'),(7517,9434,'microtubule-based flagellum','C','A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules.','2012-03-14','NSRP'),(7518,9435,'NAD biosynthetic process','P','The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH.','2013-10-27','NSRP'),(7519,9436,'glyoxylate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH.','2013-10-27','NSRP'),(7520,9437,'carnitine metabolic process','P','The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.','2013-10-27','NSRP'),(7521,9438,'methylglyoxal metabolic process','P','The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.','2013-10-27','NSRP'),(7522,9439,'cyanate metabolic process','P','The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid.','2013-10-27','NSRP'),(7523,9440,'cyanate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid.','2013-10-27','NSRP'),(7524,9441,'glycolate metabolic process','P','The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid).','2013-10-27','NSRP'),(7525,9442,'allantoin assimilation pathway','P','The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP.','2013-10-27','NSRP'),(7526,9443,'pyridoxal 5\'-phosphate salvage','P','Any process that generates pyridoxal 5\'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis.','2013-10-27','NSRP'),(7527,9444,'pyruvate oxidation','P','The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate.','2013-10-27','NSRP'),(7528,9445,'putrescine metabolic process','P','The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine.','2013-10-27','NSRP'),(7529,9446,'putrescine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine.','2013-10-27','NSRP'),(7530,9447,'putrescine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.','2013-10-27','NSRP'),(7531,9448,'gamma-aminobutyric acid metabolic process','P','The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.','2013-10-27','NSRP'),(7532,9449,'gamma-aminobutyric acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.','2013-10-27','NSRP'),(7533,9450,'gamma-aminobutyric acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.','2013-10-27','NSRP'),(7534,9451,'RNA modification','P','The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically.','2013-10-27','NSRP'),(7535,9452,'7-methylguanosine RNA capping','P','The sequence of enzymatic reactions by which the 5\' cap structure, an inverted 7-methylguanosine linked via a 5\'-5\' triphosphate bridge (m7G(5\')ppp(5\')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript.','2013-10-27','NSRP'),(7536,9453,'energy taxis','P','The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates.','2013-10-27','NSRP'),(7537,9454,'aerotaxis','P','The directed movement of a motile cell or organism in response to environmental oxygen.','2013-10-27','NSRP'),(7538,9455,'redox taxis','P','The directed movement of a motile cell or organism in response to redox potential.','2013-10-27','NSRP'),(7539,9457,'flavodoxin','F','OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide.','2013-10-27','NSRP'),(7540,9458,'cytochrome','F','OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom.','2013-10-27','NSRP'),(7541,9459,'cytochrome a','F','OBSOLETE. A cytochrome containing heme a.','2013-10-27','NSRP'),(7542,9460,'cytochrome b','F','OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b).','2013-10-27','NSRP'),(7543,9461,'cytochrome c','F','OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues.','2013-10-27','NSRP'),(7544,9462,'cytochrome d','F','OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes.','2013-10-27','NSRP'),(7545,9463,'cytochrome b/b6','F','OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis.','2013-10-27','NSRP'),(7546,9464,'cytochrome b5','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7547,9465,'soluble cytochrome b562','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7548,9466,'class I cytochrome c','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7549,9467,'monoheme class I cytochrome c','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7550,9468,'diheme class I cytochrome c','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7551,9469,'class II cytochrome c','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7552,9470,'class IIa cytochrome c','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7553,9471,'class III cytochrome c','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7554,9472,'cytochrome c3 (tetraheme)','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7555,9473,'cytochrome c7 (triheme)','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7556,9474,'nonaheme cytochrome c','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7557,9475,'high-molecular-weight cytochrome c (hexadecaheme)','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7558,9476,'class IV cytochrome c','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7559,9477,'cytochrome c1','F','OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c.','2013-10-27','NSRP'),(7560,9478,'cytochrome c554','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7561,9479,'cytochrome f','F','OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin.','2013-10-27','NSRP'),(7562,9480,'class IIb cytochrome c','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7563,9481,'aa3-type cytochrome c oxidase','F','OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.','2013-10-27','NSRP'),(7564,9482,'ba3-type cytochrome c oxidase','F','OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.','2013-10-27','NSRP'),(7565,9483,'caa3-type cytochrome c oxidase','F','OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.','2013-10-27','NSRP'),(7566,9485,'cbb3-type cytochrome c oxidase','F','OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O.','2013-10-27','NSRP'),(7567,9486,'cytochrome bo3 ubiquinol oxidase activity','F','Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space].','2013-10-27','NSRP'),(7568,9487,'glutaredoxin','F','OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase.','2013-10-27','NSRP'),(7569,9488,'amicyanin','F','OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c.','2013-10-27','NSRP'),(7570,9489,'rubredoxin','F','OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues.','2013-10-27','NSRP'),(7571,9490,'mononuclear iron electron carrier','F','OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system.','2013-10-27','NSRP'),(7572,9491,'redox-active disulfide bond electron carrier','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7573,9492,'2Fe-2S electron transfer carrier','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7574,9493,'adrenodoxin-type ferredoxin','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7575,9494,'chloroplast-type ferredoxin','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7576,9495,'thioredoxin-like 2Fe-2S ferredoxin','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7577,9496,'plastoquinol--plastocyanin reductase activity','F','Catalysis of the reaction: 2 H(+)[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H(+)[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane.','2013-10-27','NSRP'),(7578,9497,'3Fe-4S/4Fe-4S electron transfer carrier','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7579,9498,'bacterial-type ferredoxin','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7580,9499,'monocluster bacterial-type ferredoxin','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7581,9500,'dicluster bacterial-type ferredoxin','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7582,9501,'amyloplast','C','A plastid whose main function is to synthesize and store starch.','2013-10-27','NSRP'),(7583,9502,'photosynthetic electron transport chain','C','OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen).','2013-10-27','NSRP'),(7584,9503,'thylakoid light-harvesting complex','C','A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7585,9504,'cell plate','C','The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells.','2013-10-27','NSRP'),(7586,9505,'plant-type cell wall','C','A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.','2013-10-27','NSRP'),(7587,9506,'plasmodesma','C','A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.','2013-10-27','NSRP'),(7588,9507,'chloroplast','C','A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.','2013-10-27','NSRP'),(7589,9508,'plastid chromosome','C','A circular DNA molecule containing plastid encoded genes.','2013-10-27','NSRP'),(7590,9509,'chromoplast','C','A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments.','2013-10-27','NSRP'),(7591,9510,'plasmodesmatal desmotubule','C','A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell.','2013-10-27','NSRP'),(7592,9511,'plasmodesmatal endoplasmic reticulum','C','Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells.','2013-10-27','NSRP'),(7593,9512,'cytochrome b6f complex','C','Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species.','2013-10-27','NSRP'),(7594,9513,'etioplast','C','A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions.','2013-10-27','NSRP'),(7595,9514,'glyoxysome','C','A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds.','2013-10-27','NSRP'),(7596,9515,'granal stacked thylakoid','C','Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II.','2013-10-27','NSRP'),(7597,9516,'leucoplast','C','A colorless plastid involved in the synthesis of monoterpenes.','2013-10-27','NSRP'),(7598,9517,'PSII associated light-harvesting complex II','C','Protein-pigment complex associated with photosystem II.','2013-10-27','NSRP'),(7599,9518,'PSI associated light-harvesting complex I','C','Protein-pigment complex associated with photosystem I.','2013-10-27','NSRP'),(7600,9519,'middle lamella','C','Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells.','2013-10-27','NSRP'),(7601,9521,'photosystem','C','A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species.','2013-10-27','NSRP'),(7602,9522,'photosystem I','C','A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation).','2013-10-27','NSRP'),(7603,9523,'photosystem II','C','A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center.','2013-10-27','NSRP'),(7604,9524,'phragmoplast','C','Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules.','2013-10-27','NSRP'),(7605,9525,'phragmosome','C','A flattened membranous vesicle containing cell wall components.','2013-10-27','NSRP'),(7606,9526,'plastid envelope','C','The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space.','2013-10-27','NSRP'),(7607,9527,'plastid outer membrane','C','The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope.','2013-10-27','NSRP'),(7608,9528,'plastid inner membrane','C','The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma.','2013-10-27','NSRP'),(7609,9529,'plastid intermembrane space','C','The region between the inner and outer lipid bilayers of the plastid envelope.','2013-10-27','NSRP'),(7610,9530,'primary cell wall','C','A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present.','2013-10-27','NSRP'),(7611,9531,'secondary cell wall','C','A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin.','2013-10-27','NSRP'),(7612,9532,'plastid stroma','C','The proteinaceous ground substance of plastids.','2013-10-27','NSRP'),(7613,9533,'chloroplast stromal thylakoid','C','Unstacked thylakoids that connect the grana stacks through the stroma.','2013-10-27','NSRP'),(7614,9534,'chloroplast thylakoid','C','Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7615,9535,'chloroplast thylakoid membrane','C','The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7616,9536,'plastid','C','Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.','2013-10-27','NSRP'),(7617,9537,'proplastid','C','The precursor of other plastids.','2013-10-27','NSRP'),(7618,9538,'photosystem I reaction center','C','A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin.','2013-10-27','NSRP'),(7619,9539,'photosystem II reaction center','C','An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone.','2013-10-27','NSRP'),(7620,9540,'zeaxanthin epoxidase [overall] activity','F','Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O; and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O.','2013-10-27','NSRP'),(7621,9541,'etioplast prolamellar body','C','A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast.','2013-10-27','NSRP'),(7622,9542,'granum','C','Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis.','2013-10-27','NSRP'),(7623,9543,'chloroplast thylakoid lumen','C','The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7624,9544,'chloroplast ATP synthase complex','C','The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts.','2013-10-27','NSRP'),(7625,9545,'elaioplast','C','A leucoplast in which oil is stored.','2013-10-27','NSRP'),(7626,9546,'plasmodesmatal cytoplasmic sleeve','C','The space between the plasma membrane and the desmotubule of a plasmodesma.','2013-10-27','NSRP'),(7627,9547,'plastid ribosome','C','A ribosome contained within a plastid.','2013-10-27','NSRP'),(7628,9548,'plasmodesmatal plasma membrane','C','The portion of the plasma membrane surrounding a plasmodesma.','2013-10-27','NSRP'),(7629,9549,'cellulose microfibril','C','A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell.','2013-10-27','NSRP'),(7630,9550,'primary plasmodesma','C','A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis.','2013-10-27','NSRP'),(7631,9551,'secondary plasmodesma','C','A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata.','2013-10-27','NSRP'),(7632,9553,'embryo sac development','P','The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate.','2013-10-27','NSRP'),(7633,9554,'megasporogenesis','P','The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus.','2013-10-27','NSRP'),(7634,9555,'pollen development','P','The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates.','2013-10-27','NSRP'),(7635,9556,'microsporogenesis','P','The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores.','2013-10-27','NSRP'),(7636,9557,'antipodal cell differentiation','P','The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell.','2013-10-27','NSRP'),(7637,9558,'embryo sac cellularization','P','The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7638,9559,'embryo sac central cell differentiation','P','The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell.','2013-10-27','NSRP'),(7639,9560,'embryo sac egg cell differentiation','P','The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7640,9561,'megagametogenesis','P','The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center.','2013-10-27','NSRP'),(7641,9562,'embryo sac nuclear migration','P','The directed movement of an embryo sac nucleus to the pole or center of the cell.','2013-10-27','NSRP'),(7642,9563,'synergid differentiation','P','The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell.','2013-10-27','NSRP'),(7643,9566,'fertilization','P','The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).','2013-10-27','NSRP'),(7644,9567,'double fertilization forming a zygote and endosperm','P','Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7645,9568,'amyloplast starch grain','C','Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped.','2013-10-27','NSRP'),(7646,9569,'chloroplast starch grain','C','Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped.','2013-10-27','NSRP'),(7647,9570,'chloroplast stroma','C','The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.','2013-10-27','NSRP'),(7648,9571,'proplastid stroma','C','The space enclosed by the double membrane of a proplastid.','2013-10-27','NSRP'),(7649,9573,'chloroplast ribulose bisphosphate carboxylase complex','C','A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7650,9574,'preprophase band','C','A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs.','2013-10-27','NSRP'),(7651,9575,'chromoplast stroma','C','The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material.','2013-10-27','NSRP'),(7652,9576,'leucoplast stroma','C','The space enclosed by the double membrane of a leucoplast.','2013-10-27','NSRP'),(7653,9577,'elaioplast stroma','C','The space enclosed by the double membrane of an elaioplast.','2013-10-27','NSRP'),(7654,9578,'etioplast stroma','C','The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA.','2013-10-27','NSRP'),(7655,9579,'thylakoid','C','A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.','2013-10-27','NSRP'),(7656,9580,'thylakoid (sensu Bacteria)','C','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7657,9581,'detection of external stimulus','P','The series of events in which an external stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7658,9582,'detection of abiotic stimulus','P','The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7659,9583,'detection of light stimulus','P','The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal.','2013-10-27','NSRP'),(7660,9584,'detection of visible light','P','The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.','2013-10-27','NSRP'),(7661,9585,'red, far-red light phototransduction','P','The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm.','2013-10-27','NSRP'),(7662,9586,'rhodopsin mediated phototransduction','P','The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events then required to return the rhodopsin containing cell to the unexcited state.','2012-03-14','NSRP'),(7663,9587,'phototrophin mediated phototransduction','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7664,9588,'UV-A, blue light phototransduction','P','The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of approximately 400-500 nm.','2013-10-27','NSRP'),(7665,9589,'detection of UV','P','The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.','2013-10-27','NSRP'),(7666,9590,'detection of gravity','P','The series of events in which a gravitational stimulus is received and converted into a molecular signal.','2013-10-27','NSRP'),(7667,9591,'perception of mechanical stimulus','P','OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7668,9593,'detection of chemical stimulus','P','The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7669,9594,'detection of nutrient','P','The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7670,9595,'detection of biotic stimulus','P','The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal.','2013-10-27','NSRP'),(7671,9597,'detection of virus','P','The series of events in which a stimulus from a virus is received and converted into a molecular signal.','2013-10-27','NSRP'),(7672,9600,'detection of nematode','P','The series of events in which a stimulus from a nematode is received and converted into a molecular signal.','2013-10-27','NSRP'),(7673,9601,'detection of insect','P','The series of events in which a stimulus from an insect is received and converted into a molecular signal.','2013-10-27','NSRP'),(7674,9602,'detection of symbiont','P','The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(7675,9603,'detection of symbiotic fungus','P','The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal.','2013-10-27','NSRP'),(7676,9604,'detection of symbiotic bacterium','P','The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal.','2013-10-27','NSRP'),(7677,9605,'response to external stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus.','2013-10-27','NSRP'),(7678,9606,'tropism','P','The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it.','2013-10-27','NSRP'),(7679,9607,'response to biotic stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.','2013-10-27','NSRP'),(7680,9608,'response to symbiont','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(7681,9609,'response to symbiotic bacterium','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism.','2013-10-27','NSRP'),(7682,9610,'response to symbiotic fungus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism.','2013-10-27','NSRP'),(7683,9611,'response to wounding','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.','2013-10-27','NSRP'),(7684,9612,'response to mechanical stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.','2013-10-27','NSRP'),(7685,9614,'disease resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7686,9615,'response to virus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.','2013-10-27','NSRP'),(7687,9616,'virus induced gene silencing','P','Specific posttranscriptional gene inactivation (\'silencing\') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes.','2013-10-27','NSRP'),(7688,9617,'response to bacterium','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.','2013-10-27','NSRP'),(7689,9619,'resistance to pathogenic bacteria','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7690,9620,'response to fungus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.','2013-10-27','NSRP'),(7691,9622,'resistance to pathogenic fungi','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7692,9623,'response to parasitic fungus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic fungus, a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection.','2013-10-27','NSRP'),(7693,9624,'response to nematode','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode.','2013-10-27','NSRP'),(7694,9625,'response to insect','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect.','2013-10-27','NSRP'),(7695,9626,'plant-type hypersensitive response','P','The rapid, localized death of plant cells in response to invasion by a pathogen.','2013-10-27','NSRP'),(7696,9627,'systemic acquired resistance','P','The salicylic acid mediated response to a pathogen which confers broad spectrum resistance.','2013-10-27','NSRP'),(7697,9628,'response to abiotic stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus.','2013-10-27','NSRP'),(7698,9629,'response to gravity','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.','2013-10-27','NSRP'),(7699,9630,'gravitropism','P','The orientation of plant parts under the stimulation of gravity.','2013-10-27','NSRP'),(7700,9631,'cold acclimation','P','Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures.','2013-10-27','NSRP'),(7701,9632,'freezing tolerance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7702,9633,'drought tolerance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7703,9634,'heavy metal sensitivity/resistance','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(7704,9635,'response to herbicide','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants.','2013-10-27','NSRP'),(7705,9636,'response to toxic substance','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.','2013-10-27','NSRP'),(7706,9637,'response to blue light','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm.','2013-10-27','NSRP'),(7707,9638,'phototropism','P','The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it.','2013-10-27','NSRP'),(7708,9639,'response to red or far red light','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.','2013-10-27','NSRP'),(7709,9640,'photomorphogenesis','P','The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis.','2013-10-27','NSRP'),(7710,9641,'shade avoidance','P','Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome.','2013-10-27','NSRP'),(7711,9642,'response to light intensity','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.','2013-10-27','NSRP'),(7712,9643,'photosynthetic acclimation','P','A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light.','2013-10-27','NSRP'),(7713,9644,'response to high light intensity','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.','2013-10-27','NSRP'),(7714,9645,'response to low light intensity stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2.','2013-10-27','NSRP'),(7715,9646,'response to absence of light','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli.','2013-10-27','NSRP'),(7716,9647,'skotomorphogenesis','P','The control of plant growth, development, and differentiation in response to growth in darkness.','2013-10-27','NSRP'),(7717,9648,'photoperiodism','P','Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the \'critical day length\'. The critical day length varies between species.','2013-10-27','NSRP'),(7718,9649,'entrainment of circadian clock','P','The synchronization of a circadian rhythm to environmental time cues such as light.','2013-10-27','NSRP'),(7719,9650,'UV protection','P','Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV.','2013-10-27','NSRP'),(7720,9651,'response to salt stress','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.','2013-10-27','NSRP'),(7721,9652,'thigmotropism','P','The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it.','2013-10-27','NSRP'),(7722,9653,'anatomical structure morphogenesis','P','The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.','2013-10-27','NSRP'),(7723,9654,'photosystem II oxygen evolving complex','C','A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ).','2013-10-27','NSRP'),(7724,9655,'PSII associated light-harvesting complex II, core complex','C','The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center.','2013-10-27','NSRP'),(7725,9656,'PSII associated light-harvesting complex II, peripheral complex','C','Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light.','2013-10-27','NSRP'),(7726,9657,'plastid organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid.','2013-10-27','NSRP'),(7727,9658,'chloroplast organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast.','2013-10-27','NSRP'),(7728,9659,'leucoplast organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes.','2013-10-27','NSRP'),(7729,9660,'amyloplast organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch.','2013-10-27','NSRP'),(7730,9661,'chromoplast organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments.','2013-10-27','NSRP'),(7731,9662,'etioplast organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions.','2013-10-27','NSRP'),(7732,9663,'plasmodesma organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.','2013-10-27','NSRP'),(7733,9664,'plant-type cell wall organization','P','A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7734,9665,'plastid inheritance','P','The partitioning of plastids between daughter cells at cell division.','2013-10-27','NSRP'),(7735,9666,'plastid outer membrane organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid.','2013-10-27','NSRP'),(7736,9667,'plastid inner membrane organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid.','2013-10-27','NSRP'),(7737,9668,'plastid membrane organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid.','2013-10-27','NSRP'),(7738,9669,'sucrose:monovalent cation symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in).','2013-10-27','NSRP'),(7739,9670,'triose-phosphate:phosphate antiporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out).','2013-10-27','NSRP'),(7740,9671,'nitrate:hydrogen symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in).','2013-10-27','NSRP'),(7741,9672,'auxin:hydrogen symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in).','2013-10-27','NSRP'),(7742,9673,'low affinity phosphate transmembrane transporter activity','F','Catalysis of the transfer of phosphate from one side of the membrane to the other. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.','2013-10-27','NSRP'),(7743,9674,'potassium:sodium symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in).','2013-10-27','NSRP'),(7744,9675,'high affinity sulfate:hydrogen symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.','2013-10-27','NSRP'),(7745,9676,'low affinity sulfate:hydrogen symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.','2013-10-27','NSRP'),(7746,9677,'double fertilization forming two zygotes','P','Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis.','2013-10-27','NSRP'),(7747,9678,'hydrogen-translocating pyrophosphatase activity','F','Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force.','2013-10-27','NSRP'),(7748,9679,'hexose:hydrogen symporter activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in).','2013-10-27','NSRP'),(7749,9682,'induced systemic resistance','P','A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling.','2013-10-27','NSRP'),(7750,9683,'indoleacetic acid metabolic process','P','The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants.','2013-10-27','NSRP'),(7751,9684,'indoleacetic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants.','2013-10-27','NSRP'),(7752,9685,'gibberellin metabolic process','P','The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.','2013-10-27','NSRP'),(7753,9686,'gibberellin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.','2013-10-27','NSRP'),(7754,9687,'abscisic acid metabolic process','P','The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid.','2013-10-27','NSRP'),(7755,9688,'abscisic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid.','2013-10-27','NSRP'),(7756,9689,'induction of phytoalexin biosynthetic process','P','The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection.','2013-10-27','NSRP'),(7757,9690,'cytokinin metabolic process','P','The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators.','2013-10-27','NSRP'),(7758,9691,'cytokinin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators.','2013-10-27','NSRP'),(7759,9692,'ethylene metabolic process','P','The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.','2013-10-27','NSRP'),(7760,9693,'ethylene biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.','2013-10-27','NSRP'),(7761,9694,'jasmonic acid metabolic process','P','The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid.','2013-10-27','NSRP'),(7762,9695,'jasmonic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative.','2013-10-27','NSRP'),(7763,9696,'salicylic acid metabolic process','P','The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid.','2013-10-27','NSRP'),(7764,9697,'salicylic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid.','2013-10-27','NSRP'),(7765,9698,'phenylpropanoid metabolic process','P','The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid.','2013-10-27','NSRP'),(7766,9699,'phenylpropanoid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid.','2013-10-27','NSRP'),(7767,9700,'indole phytoalexin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response.','2013-10-27','NSRP'),(7768,9701,'isoflavonoid phytoalexin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection.','2013-10-27','NSRP'),(7769,9702,'L-arabinokinase activity','F','Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(7770,9703,'nitrate reductase (NADH) activity','F','Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+.','2013-10-27','NSRP'),(7771,9704,'de-etiolation','P','The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll.','2013-10-27','NSRP'),(7772,9705,'plant-type vacuole membrane','C','The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana.','2013-10-27','NSRP'),(7773,9706,'chloroplast inner membrane','C','The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma.','2013-10-27','NSRP'),(7774,9707,'chloroplast outer membrane','C','The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope.','2013-10-27','NSRP'),(7775,9708,'benzyl isoquinoline alkaloid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings.','2013-10-27','NSRP'),(7776,9709,'terpenoid indole alkaloid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate).','2013-10-27','NSRP'),(7777,9710,'tropane alkaloid biosynthetic process','P','The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system.','2013-10-27','NSRP'),(7778,9711,'purine alkaloid biosynthetic process','P','The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure.','2013-10-27','NSRP'),(7779,9712,'catechol-containing compound metabolic process','P','The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent.','2013-10-27','NSRP'),(7780,9713,'catechol-containing compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.','2013-10-27','NSRP'),(7781,9714,'chalcone metabolic process','P','The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives.','2013-10-27','NSRP'),(7782,9715,'chalcone biosynthetic process','P','The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives.','2013-10-27','NSRP'),(7783,9716,'flavonoid phytoalexin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection.','2013-10-27','NSRP'),(7784,9717,'isoflavonoid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids.','2013-10-27','NSRP'),(7785,9718,'anthocyanin-containing compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins.','2013-10-27','NSRP'),(7786,9719,'response to endogenous stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.','2013-10-27','NSRP'),(7787,9720,'detection of hormone stimulus','P','The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7788,9721,'detection of auxin stimulus','P','The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7789,9722,'detection of cytokinin stimulus','P','The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7790,9723,'response to ethylene stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus.','2013-10-27','NSRP'),(7791,9724,'detection of abscisic acid stimulus','P','The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7792,9725,'response to hormone stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.','2013-10-27','NSRP'),(7793,9726,'detection of endogenous stimulus','P','The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7794,9727,'detection of ethylene stimulus','P','The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7795,9728,'detection of gibberellic acid stimulus','P','The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7796,9729,'detection of brassinosteroid stimulus','P','The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7797,9730,'detection of carbohydrate stimulus','P','The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7798,9731,'detection of sucrose stimulus','P','The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7799,9732,'detection of hexose stimulus','P','The series of events in which a stimulus from a hexose is received and converted into a molecular signal.','2013-10-27','NSRP'),(7800,9733,'response to auxin stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus.','2013-10-27','NSRP'),(7801,9734,'auxin mediated signaling pathway','P','The series of molecular signals generated in response to detection of auxin.','2013-10-27','NSRP'),(7802,9735,'response to cytokinin stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.','2013-10-27','NSRP'),(7803,9736,'cytokinin mediated signaling pathway','P','A series of molecular signals induced by the detection of cytokinin.','2013-10-27','NSRP'),(7804,9737,'response to abscisic acid stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.','2013-10-27','NSRP'),(7805,9738,'abscisic acid mediated signaling pathway','P','A series of molecular signals mediated by the detection of abscisic acid.','2013-10-27','NSRP'),(7806,9739,'response to gibberellin stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus.','2013-10-27','NSRP'),(7807,9740,'gibberellic acid mediated signaling pathway','P','A series of molecular signals mediated by the detection of gibberellic acid.','2013-10-27','NSRP'),(7808,9741,'response to brassinosteroid stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus.','2013-10-27','NSRP'),(7809,9742,'brassinosteroid mediated signaling pathway','P','A series of molecular signals mediated by the detection of brassinosteroid.','2013-10-27','NSRP'),(7810,9743,'response to carbohydrate stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.','2013-10-27','NSRP'),(7811,9744,'response to sucrose stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.','2013-10-27','NSRP'),(7812,9745,'sucrose mediated signaling','P','A series of molecular signals mediated by the detection of sucrose.','2013-10-27','NSRP'),(7813,9746,'response to hexose stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.','2013-10-27','NSRP'),(7814,9747,'hexokinase-dependent signaling','P','A series of molecular signals mediated by hexose and dependent on the detection of hexokinase.','2013-10-27','NSRP'),(7815,9748,'hexokinase-independent signaling','P','A series of molecular signals mediated by hexose and independent of hexokinase.','2013-10-27','NSRP'),(7816,9749,'response to glucose stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.','2013-10-27','NSRP'),(7817,9750,'response to fructose stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus.','2013-10-27','NSRP'),(7818,9751,'response to salicylic acid stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus.','2013-10-27','NSRP'),(7819,9752,'detection of salicylic acid stimulus','P','The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(7820,9753,'response to jasmonic acid stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus.','2013-10-27','NSRP'),(7821,9754,'detection of jasmonic acid stimulus','P','The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule.','2013-10-27','NSRP'),(7822,9755,'hormone-mediated signaling pathway','P','A series of molecular signals mediated by the detection of a hormone.','2013-10-27','NSRP'),(7823,9756,'carbohydrate mediated signaling','P','A series of molecular signals mediated by the detection of carbohydrate.','2013-10-27','NSRP'),(7824,9757,'hexose mediated signaling','P','A series of molecular signals mediated by the detection of hexose.','2013-10-27','NSRP'),(7825,9758,'carbohydrate utilization','P','A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism\'s metabolism.','2013-10-27','NSRP'),(7826,9759,'indole glucosinolate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan.','2013-10-27','NSRP'),(7827,9760,'C4 photosynthesis','P','The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch.','2013-10-27','NSRP'),(7828,9761,'CAM photosynthesis','P','The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis.','2013-10-27','NSRP'),(7829,9762,'NADP-malic enzyme C4 photosynthesis','P','The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme.','2013-10-27','NSRP'),(7830,9763,'NAD-malic enzyme C4 photosynthesis','P','The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme.','2013-10-27','NSRP'),(7831,9764,'PEP carboxykinase C4 photosynthesis','P','The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK).','2013-10-27','NSRP'),(7832,9765,'photosynthesis, light harvesting','P','Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers.','2013-10-27','NSRP'),(7833,9766,'primary charge separation','P','In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes.','2013-10-27','NSRP'),(7834,9767,'photosynthetic electron transport chain','P','A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient.','2013-10-27','NSRP'),(7835,9768,'photosynthesis, light harvesting in photosystem I','P','After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center.','2013-10-27','NSRP'),(7836,9769,'photosynthesis, light harvesting in photosystem II','P','After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center.','2013-10-27','NSRP'),(7837,9770,'primary charge separation in photosystem I','P','Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side.','2013-10-27','NSRP'),(7838,9771,'primary charge separation in photosystem II','P','Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side.','2013-10-27','NSRP'),(7839,9772,'photosynthetic electron transport in photosystem II','P','A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I.','2013-10-27','NSRP'),(7840,9773,'photosynthetic electron transport in photosystem I','P','A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP.','2013-10-27','NSRP'),(7841,9777,'photosynthetic phosphorylation','P','Any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation.','2013-10-27','NSRP'),(7842,9778,'cyclic photosynthetic phosphorylation','P','A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I.','2013-10-27','NSRP'),(7843,9779,'noncyclic photosynthetic phosphorylation','P','A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II.','2013-10-27','NSRP'),(7844,9780,'photosynthetic NADP+ reduction','P','An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions.','2013-10-27','NSRP'),(7845,9781,'photosynthetic water oxidation','P','OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle.','2013-10-27','NSRP'),(7846,9782,'photosystem I antenna complex','C','The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs).','2013-10-27','NSRP'),(7847,9783,'photosystem II antenna complex','C','The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs).','2013-10-27','NSRP'),