(18449,34795,'cyclohexane monooxygenase activity','F','Catalysis of the reaction: cyclohexane + O2 + NAD(P)H + H+ = cyclohexanol + NAD(P)+ + H2O.','2013-10-27','NSRP'),(18450,34796,'adipate-CoA ligase activity','F','Catalysis of the reaction: adipate + CoASH = adipyl-CoA + OH-.','2013-10-27','NSRP'),(18451,34797,'fosfomycin 2-glutathione ligase activity','F','Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + glutathione = hydrogen (1R,2R)-1-glutathio-2-hydroxypropylphosphonic acid.','2013-10-27','NSRP'),(18452,34798,'fosfomycin 2-L-cysteine ligase activity','F','Catalysis of the reaction: hydrogen (2R,3S)-3-methyloxiran-2-ylphosphonic acid + L-cysteine = hydrogen (1R,2R)-1-L-cysteine-2-hydroxypropylphosphonic acid.','2013-10-27','NSRP'),(18453,34799,'dihydride TNP tautomerase activity','F','Catalysis of the reaction: TNP dihydride Meisenheimer complex (aci form) = TNP dihydride Meisenheimer complex (nitro form).','2013-10-27','NSRP'),(18454,34800,'trinitrophenol dihydride denitratase activity','F','Catalysis of the reaction: trinitrophenol dihydride Meisenheimer complex (aci form) = 2,4-dinitrophenol hydride Meisenheimer complex + NO2. Trinitrophenol is also known as TNP and dinitrophenol is also known as DNP.','2013-10-27','NSRP'),(18455,34801,'2,4-dinitrocyclohexanone hydrolase activity','F','Catalysis of the reaction: 2,4-dinitrocyclohexanone + OH- = 4,6-dinitrohexanoate.','2013-10-27','NSRP'),(18456,34802,'branched-chain dodecylbenzene sulfonate monooxygenase activity','F','Catalysis of the reaction: branched-chain dodecylbenzene sulfonate + 1/2 O2 + H+ = sulfurous acid + branched-chain dodecyl-4-hydroxy-benzene + sulfite.','2013-10-27','NSRP'),(18457,34803,'3-hydroxy-2-naphthoate 2,3-dioxygenase activity','F','Catalysis of the reaction: 3-hydroxy-2-naphthoate + O2 = (3E)-3-[(6Z)-6-(carboxymethylene)cyclohexa-2,4-dien-1-ylidene]-2-oxopropanate.','2013-10-27','NSRP'),(18458,34804,'benzo(a)pyrene 11,12-epoxidase activity','F','Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-11,12-epoxide.','2013-10-27','NSRP'),(18459,34805,'benzo(a)pyrene-trans-11,12-dihydrodiol dehydrogenase activity','F','Catalysis of the reaction: benzo(a)pyrene-trans-11,12-dihydrodiol = 11,12-dihydroxybenzo(a)pyrene + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18460,34806,'benzo(a)pyrene 11,12-dioxygenase activity','F','Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-11,12-dihydrodiol.','2013-10-27','NSRP'),(18461,34807,'4,5-dihydroxybenzo(a)pyrene methyltransferase activity','F','Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + C1 unit = hydroxymethoxybenzo(a)pyrene.','2013-10-27','NSRP'),(18462,34808,'benzo(a)pyrene 4,5-dioxygenase activity','F','Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-4,5-dihydrodiol.','2013-10-27','NSRP'),(18463,34809,'benzo(a)pyrene-cis-4,5-dihydrodiol dehydrogenase activity','F','Catalysis of the reaction: benzo(a)pyrene-cis-4,5-dihydrodiol = 4,5-dihydroxybenzo(a)pyrene + H2.','2013-10-27','NSRP'),(18464,34810,'4,5-dihydroxybenzo(a)pyrene dioxygenase activity','F','Catalysis of the reaction: 4,5-dihydroxybenzo(a)pyrene + O2 = 4,5-chrysenedicarboxylate.','2013-10-27','NSRP'),(18465,34811,'benzo(a)pyrene 9,10-dioxygenase activity','F','Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol.','2013-10-27','NSRP'),(18466,34812,'9,10-dihydroxybenzo(a)pyrene dioxygenase activity','F','Catalysis of the reaction: 9,10-dihydroxybenzo(a)pyrene + O2 = cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate.','2013-10-27','NSRP'),(18467,34813,'benzo(a)pyrene 7,8-dioxygenase activity','F','Catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-7,8-dihydrodiol.','2013-10-27','NSRP'),(18468,34814,'7,8-dihydroxy benzo(a)pyrene dioxygenase activity','F','Catalysis of the reaction: benzo(a)pyrene-cis-7,8-dihydrodiol + O2 = cis-4-(7-hydroxypyren-8-yl)-2-oxobut-3-enoate.','2013-10-27','NSRP'),(18469,34815,'cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity','F','Catalysis of the reaction: cis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate = 10-oxabenzo(def)chrysen-9-one + formate + H+.','2013-10-27','NSRP'),(18470,34816,'anthracene 9,10-dioxygenase activity','F','Catalysis of the reaction: anthracene + 2 H2O = cis-9,10-dihydroanthracene-9,10-diol.','2013-10-27','NSRP'),(18471,34817,'cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity','F','Catalysis of the reaction: cis-9,10-dihydroanthracene-9,10-diol = 9,10-anthraquinone + 4 H+ + 4 e-.','2013-10-27','NSRP'),(18472,34818,'ADD 9alpha-hydroxylase activity','F','Catalysis of the reaction: androsta-1,4-diene-3,17-dione + reduced ferredoxin + O2 = 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + oxidized ferredoxin.','2013-10-27','NSRP'),(18473,34819,'3-HSA hydroxylase activity','F','Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADPH + H+ + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + NADP+ + H2O.','2013-10-27','NSRP'),(18474,34820,'4,9-DSHA hydrolase activity','F','Catalysis of the reaction: (3E,1Z)-4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate + H2O = (2E,4E)-2-hydroxyhexa-2,4-dienoate + 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oate + H+.','2013-10-27','NSRP'),(18475,34821,'citronellol dehydrogenase activity','F','Catalysis of the reaction: citronellol + NAD+ = citronellal + NADH + H+.','2013-10-27','NSRP'),(18476,34822,'citronellal dehydrogenase activity','F','Catalysis of the reaction: citronellal + NAD+ + OH- = citronellate + NADH + H+.','2013-10-27','NSRP'),(18477,34823,'citronellyl-CoA ligase activity','F','Catalysis of the reaction: citronellate + CoASH + ATP = citronellyl-CoA + AMP + PPi.','2013-10-27','NSRP'),(18478,34824,'citronellyl-CoA dehydrogenase activity','F','Catalysis of the reaction: citronellyl-CoA + NAH+ = cis-geranyl-CoA + NADH + H+.','2013-10-27','NSRP'),(18479,34825,'tetralin ring-hydroxylating dioxygenase activity','F','Catalysis of the reaction: tetralin + O2 + NADH + H+ = cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+.','2013-10-27','NSRP'),(18480,34826,'1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity','F','Catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+.','2013-10-27','NSRP'),(18481,34827,'1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity','F','Catalysis of the reaction: 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + O2 = 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H+.','2013-10-27','NSRP'),(18482,34828,'4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate hydrolase activity','F','Catalysis of the reaction: 4-(2-oxocyclohexyl)-2-hydroxy-buta-2,4-dienoate + H2O = 2-hydroxydec-2,4-diene-1,10-dioate + H+.','2013-10-27','NSRP'),(18483,34829,'2-hydroxydec-2,4-diene-1,10-dioate hydratase activity','F','Catalysis of the reaction: 2-hydroxydec-2,4-diene-1,10-dioate + H2O = (2Z)-2,4-dihydroxydec-2-enedioate.','2013-10-27','NSRP'),(18484,34830,'(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity','F','Catalysis of the reaction: (2Z)-2,4-dihydroxydec-2-enedioate = pyruvate + 7-oxoheptanoate.','2013-10-27','NSRP'),(18485,34831,'(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity','F','Catalysis of the reaction: (R)-1,2,3,4-tetrahydronaphthol = 1,2,3,4-tetrahydronaphthalone + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18486,34832,'geranial dehydrogenase activity','F','Catalysis of the reaction: geranial + NAD+ + OH- = geranylate + NADH + H+.','2013-10-27','NSRP'),(18487,34833,'geranylate CoA-transferase activity','F','Catalysis of the reaction: geranylate + CoASH = trans-geranyl-CoA + OH-.','2013-10-27','NSRP'),(18488,34834,'2-mercaptobenzothiazole dioxygenase activity','F','Catalysis of the reaction: 2-mercaptobenzothiazole + O2 + 2 H+ + 2 e- = 2-mercaptobenzothiazole-cis-6,7-dihydrodiol.','2013-10-27','NSRP'),(18489,34835,'2-mercaptobenzothiazole monooxygenase activity','F','Catalysis of the reaction: 2-mercaptobenzothiazole + 1/2 O2 = 6-hydroxy-2-mercaptobenzothiazole.','2013-10-27','NSRP'),(18490,34836,'6-hydroxy-2-mercaptobenzothiazole monooxygenase activity','F','Catalysis of the reaction: 6-hydroxy-2-mercaptobenzothiazole + 1/2 O2 = 6,7-dihydroxy-2-mercaptobenzothiazole.','2013-10-27','NSRP'),(18491,34837,'2-mercaptobenzothiazole-cis-6,7-dihydrodiol dehydrogenase activity','F','Catalysis of the reaction: 2-mercaptobenzothiazole-cis-6,7-dihydrodiol = 6,7-dihydroxy-2-mercaptobenzothiazole + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18492,34838,'menthone dehydrogenase activity','F','Catalysis of the reaction: (-)-(2S,5R)-menthone + NAD+ = (5R)-menth-2-enone + NADH + H+.','2013-10-27','NSRP'),(18493,34839,'menth-2-enone hydratase activity','F','Catalysis of the reaction: (5R)-menth-2-enone + H2O = (5R)-3-hydroxymenthone.','2013-10-27','NSRP'),(18494,34840,'3-hydroxymenthone dehydrogenase activity','F','Catalysis of the reaction: (5R)-3-hydroxymenthone + NAD+ = mentha-1,3-dione + NADH + H+.','2013-10-27','NSRP'),(18495,34841,'mentha-1,3-dione-CoA ligase activity','F','Catalysis of the reaction: mentha-1,3-dione + CoASH = 3,7-dimethyl-5-oxo-octyl-CoA.','2013-10-27','NSRP'),(18496,34842,'thiophene-2-carboxylate-CoA ligase activity','F','Catalysis of the reaction: thiophene-2-carboxylate + ATP + CoASH = thiophene-2-carboxyl-CoA + AMP + PPi.','2013-10-27','NSRP'),(18497,34843,'2-oxoglutaryl-CoA thioesterase activity','F','Catalysis of the reaction: 2-oxoglutaryl-CoA + OH- = 2-oxoglutarate + CoASH.','2013-10-27','NSRP'),(18498,34844,'naphthyl-2-methyl-succinate CoA-transferase activity','F','Catalysis of the reaction: naphthyl-2-methyl-succinate + succinyl-CoA = naphthyl-2-methyl-succinyl-CoA + succinate.','2013-10-27','NSRP'),(18499,34845,'naphthyl-2-methyl-succinyl-CoA dehydrogenase activity','F','Catalysis of the reaction: naphthyl-2-methyl-succinyl-CoA = naphthyl-2-methylene-succinyl-CoA + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18500,34846,'naphthyl-2-methylene-succinyl-CoA lyase activity','F','Catalysis of the reaction: naphthyl-2-methylene-succinyl-CoA + H2O = naphthyl-2-hydroxymethyl-succinyl-CoA.','2013-10-27','NSRP'),(18501,34847,'naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity','F','Catalysis of the reaction: naphthyl-2-hydroxymethyl-succinyl-CoA = naphthyl-2-oxomethyl-succinyl-CoA + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18502,34848,'naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity','F','Catalysis of the reaction: naphthyl-2-oxomethyl-succinyl-CoA + CoASH = 2-naphthoyl-CoA + succinyl-CoA.','2013-10-27','NSRP'),(18503,34849,'2-naphthoate CoA-transferase activity','F','Catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH.','2013-10-27','NSRP'),(18504,34850,'isooctane monooxygenase activity','F','Catalysis of the reaction: isooctane + 1/2 O2 = 2,4,4-trimethyl-1-pentanol.','2013-10-27','NSRP'),(18505,34851,'2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity','F','Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + CoASH = pivalyl-CoA + propanoyl-CoA.','2013-10-27','NSRP'),(18506,34852,'4,4-dimethyl-3-oxopentanal dehydrogenase activity','F','Catalysis of the reaction: 4,4-dimethyl-3-oxopentanal + H2O = 4,4-dimethyl-3-oxopentanoate + 3 H+ + 2 e-.','2013-10-27','NSRP'),(18507,34853,'2,4,4-trimethyl-3-oxopentanoate decarboxylase activity','F','Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoate + H+ = 2,2-dimethyl-3-pentanone + CO2.','2013-10-27','NSRP'),(18508,34854,'4,4-dimethyl-3-oxopentanoate decarboxylase activity','F','Catalysis of the reaction: 4,4-dimethyl-3-oxopentanoate + H+ = 3,3-dimethyl-2-butanone + CO2.','2013-10-27','NSRP'),(18509,34855,'4-AD 9alpha-hydroxylase activity','F','Catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O.','2013-10-27','NSRP'),(18510,34856,'2-hydroxyhexa-2,4-dienoate hydratase activity','F','Catalysis of the reaction: (2E,4E)-2-hydroxyhexa-2,4-dienoate + H2O = 4-hydroxy-2-oxohexanoate.','2013-10-27','NSRP'),(18511,34857,'2-(methylthio)benzothiazole monooxygenase activity','F','Catalysis of the reaction: 2-(methylthio)benzothiazole + 1/2 O2 = 2-(methylsulfinyl)benzothiazole.','2013-10-27','NSRP'),(18512,34858,'2-hydroxybenzothiazole monooxygenase activity','F','Catalysis of the reaction: 2-hydroxybenzothiazole + 1/2 O2 = 2,6-dihydroxybenzothiazole.','2013-10-27','NSRP'),(18513,34859,'benzothiazole monooxygenase activity','F','Catalysis of the reaction: benzothiazole + 1/2 O2 = 2-hydroxybenzothiazole.','2013-10-27','NSRP'),(18514,34860,'2-mercaptobenzothiazole desulfurase activity','F','Catalysis of the reaction: 2-mercaptobenzothiazole + reduced acceptor = benzothiazole + hydrogen sulfide + oxidized acceptor.','2013-10-27','NSRP'),(18515,34861,'benzothiazole-2-sulfonate hydrolase activity','F','Catalysis of the reaction: benzothiazole-2-sulfonate + H2O = 2-hydroxybenzothiazole + HSO3-.','2013-10-27','NSRP'),(18516,34862,'2,6-dihydroxybenzothiazole monooxygenase activity','F','Catalysis of the reaction: 2,6-dihydroxybenzothiazole + 1/2 O2 = 2,6,7-trihydroxybenzothiazole.','2013-10-27','NSRP'),(18517,34863,'2,4,4-trimethyl-1-pentanol dehydrogenase activity','F','Catalysis of the reaction: 2,4,4-trimethyl-1-pentanol = 2,4,4-trimethylpentanal + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18518,34864,'2,4,4-trimethylpentanal dehydrogenase activity','F','Catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-.','2013-10-27','NSRP'),(18519,34865,'2,4,4-trimethylpentanoate-CoA ligase activity','F','Catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-.','2013-10-27','NSRP'),(18520,34866,'2,4,4-trimethylpentanoyl-CoA dehydrogenase activity','F','Catalysis of the reaction: 2,4,4-trimethylpentanoyl-CoA = 2,4,4-trimethylpent-2-enoyl-CoA + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18521,34867,'2,4,4-trimethylpent-2-enoyl-CoA hydratase activity','F','Catalysis of the reaction: 2,4,4-trimethylpent-2-enoyl-CoA + H2O = 2,4,4-trimethyl-3-hydroxypentanoyl-CoA.','2013-10-27','NSRP'),(18522,34868,'2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity','F','Catalysis of the reaction: 2,4,4-trimethyl-3-hydroxypentanoyl-CoA = 2,4,4-trimethyl-3-oxopentanoyl-CoA + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18523,34869,'2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity','F','Catalysis of the reaction: 2,4,4-trimethyl-3-oxopentanoyl-CoA + OH- = 2,4,4-trimethyl-3-oxopentanoate + CoASH.','2013-10-27','NSRP'),(18524,34870,'pinacolone 5-monooxygenase activity','F','Catalysis of the reaction: 2,2-dimethyl-3-pentanone + 1/2 O2 = 1-hydroxy-4,4-dimethylpentan-3-one.','2013-10-27','NSRP'),(18525,34871,'1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity','F','Catalysis of the reaction: 1-hydroxy-4,4-dimethylpentan-3-one = 4,4-dimethyl-3-oxopentanal + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18526,34872,'trans-geranyl-CoA isomerase activity','F','Catalysis of the reaction: trans-geranyl-CoA = cis-geranyl-CoA.','2013-10-27','NSRP'),(18527,34873,'thioacetamide S-oxygenase activity','F','Catalysis of the reaction: thioacetamide + O2 + 2 H+ + 2 e- = thioacetamide S-oxide + H2O.','2013-10-27','NSRP'),(18528,34874,'thioacetamide S-oxide S-oxygenase activity','F','Catalysis of the reaction: thioacetamide S-oxide + O2 + 2 H+ + 2 e- = thioacetamide S,S-dioxide + H2O.','2013-10-27','NSRP'),(18529,34875,'caffeine oxidase activity','F','Catalysis of the reaction: caffeine + O2 + 2 H+ + 2 e- = 1,3,7-trimethyluric acid + H2O.','2013-10-27','NSRP'),(18530,34876,'isonicotinic acid hydrazide hydrolase activity','F','Catalysis of the reaction: isoniazid + H2O = isonicotinate + hydrazine.','2013-10-27','NSRP'),(18531,34877,'isonicotinate dehydrogenase activity','F','Catalysis of the reaction: isonicotinate + acceptor + H2O = 2-hydroxyisonicotinate + reduced acceptor.','2013-10-27','NSRP'),(18532,34878,'2-hydroxyisonicotinate dehydrogenase activity','F','Catalysis of the reaction: 2-hydroxyisonicotinate + acceptor + H2O = citrazinate + reduced acceptor.','2013-10-27','NSRP'),(18533,34879,'2,3,6-trihydroxyisonicotinate decarboxylase activity','F','Catalysis of the reaction: 2,3,6-trihydroxyisonicotinate = 2,3,6-trihydroxypyridine + CO2.','2013-10-27','NSRP'),(18534,34880,'citrazinate dehydrogenase activity','F','Catalysis of the reaction: citrazinate + H2O = 2,3,6-trihydroxyisonicotinate + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18535,34881,'citrazinate hydrolase activity','F','Catalysis of the reaction: citrazinate + H2O = cis-aconitamide.','2013-10-27','NSRP'),(18536,34882,'cis-aconitamide amidase activity','F','Catalysis of the reaction: cis-aconitamide + H2O = cis-aconitate + HN3.','2013-10-27','NSRP'),(18537,34883,'isonicotinate reductase activity','F','OBSOLETE. Catalysis of the reaction: isonicotinate + 2 H+ + 2 e- = 1,4-dihydroisonicotinate.','2013-10-27','NSRP'),(18538,34884,'gamma-N-formylaminovinylacetaldehyde dehydrogenase activity','F','OBSOLETE. Catalysis of the reaction: gamma-N-formylaminovinylacetaldehyde + H2O = gamma-N-formylaminovinylacetate + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18539,34885,'gamma-N-formylaminovinylacetate hydrolase activity','F','Catalysis of the reaction: gamma-N-formylaminovinylacetate + H2O = gamma-aminovinylacetate + HCOOH.','2013-10-27','NSRP'),(18540,34886,'gamma-aminovinylacetate deaminase activity','F','Catalysis of the reaction: gamma-aminovinylacetate + H2O = succinic semialdehyde + NH3.','2013-10-27','NSRP'),(18541,34887,'1,4-dihydroisonicotinate 2,3-dioxygenase activity','F','OBSOLETE. Catalysis of the reaction: 1,4-dihydroisonicotinate + O2 = gamma-N-formylaminovinylacetaldehyde + CO2.','2013-10-27','NSRP'),(18542,34888,'endosulfan monooxygenase I activity','F','Catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O.','2013-10-27','NSRP'),(18543,34889,'endosulfan hemisulfate sulfatase activity','F','Catalysis of the reaction: endosulfan hemisulfate + H2O = endosulfan monoalcohol + 2 H+ + sulfate.','2013-10-27','NSRP'),(18544,34890,'endosulfan diol hydrolyase (cyclizing) activity','F','Catalysis of the reaction: endosulfan diol = endosulfan ether + H2O.','2013-10-27','NSRP'),(18545,34891,'endosulfan diol dehydrogenase activity','F','Catalysis of the reaction: endosulfan diol = endosulfan hydroxyether + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18546,34892,'endosulfan lactone lactonase activity','F','Catalysis of the reaction: endosulfan lactone + H2O = endosulfan hydroxycarboxylate + H+.','2013-10-27','NSRP'),(18547,34893,'N-nitrodimethylamine hydroxylase activity','F','Catalysis of the reaction: N-nitrodimethylamine + O2 + 2 H+ + 2 e- = N-nitromethylamine + formaldehyde + H2O.','2013-10-27','NSRP'),(18548,34894,'4-hydroxypyridine-3-hydroxylase activity','F','Catalysis of the reaction: 4-hydroxypyridine + O2 + H+ + NADPH = pyridine-3,4-diol + H2O + NADP+.','2013-10-27','NSRP'),(18549,34895,'pyridine-3,4-diol dioxygenase activity','F','Catalysis of the reaction: pryidine-3,4-diol + O2 = 3-(N-formyl)-formiminopyruvate.','2013-10-27','NSRP'),(18550,34896,'3-formiminopyruvate hydrolase activity','F','Catalysis of the reaction: 3-formiminopyruvate + H2O = 3-formylpyruvate + HN3.','2013-10-27','NSRP'),(18551,34897,'4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity','F','Catalysis of the reaction: 4-(1-ethyl-1,4-dimethyl-pentyl)phenol + O2 + 2 H+ + 2 e- = hydroquinone + 3,6-dimethylheptan-3-ol.','2013-10-27','NSRP'),(18552,34898,'hexadecyltrimethylammonium chloride monooxygenase activity','F','Catalysis of the reaction: hexadecyltrimethylammonium chloride + NAD(P)H + H+ + O2 = trimethylamine + hexadecanal + NAD(P)+ + H2O.','2013-10-27','NSRP'),(18553,34899,'trimethylamine monooxygenase activity','F','Catalysis of the reaction: N,N,N-trimethylamine + NADPH + H+ + O2 = N,N,N-trimethylamine N-oxide + NADP+ + H2O.','2013-10-27','NSRP'),(18554,34900,'3-(N-formyl)-formiminopyruvate hydrolase activity','F','Catalysis of the reaction: 3-(N-formyl)-formiminopyruvate + H2O = 3-formiminopyruvate + formate.','2013-10-27','NSRP'),(18555,34901,'endosulfan hydroxyether dehydrogenase activity','F','Catalysis of the reaction: endosulfan hydroxyether = endosulfan lactone + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18556,34902,'endosulfan sulfate hydrolase activity','F','Catalysis of the reaction: endosulfan sulfate + H2O = endosulfan diol + sulfite.','2013-10-27','NSRP'),(18557,34903,'endosulfan ether monooxygenase activity','F','Catalysis of the reaction: endosulfan ether + O2 + 2 H+ + 2 e- = endosulfan hydroxyether + H2O.','2013-10-27','NSRP'),(18558,34904,'5-chloro-2-oxopent-4-enoate hydratase activity','F','Catalysis of the reaction: 5-chloro-2-oxopent-4-enoate + H2O = 5-chloro-4-hydroxy-2-oxopentanate.','2013-10-27','NSRP'),(18559,34905,'5-chloro-4-hydroxy-2-oxopentanate aldolase activity','F','Catalysis of the reaction: 5-chloro-4-hydroxy-2-oxopentanate = pyruvate + chloroacetaldehyde.','2013-10-27','NSRP'),(18560,34906,'N-isopropylaniline 1,2-dixoxygenase activity','F','Catalysis of the reaction: N-isopropylaniline + O2 + 2 H+ + NADH = catechol + NAD+ + isopropylamine.','2013-10-27','NSRP'),(18561,34907,'acetanilide 1,2-dioxygenase activity','F','Catalysis of the reaction: acetanilide + O2 + 2 H+ + NADH = catechol + NAD+ + acetamide.','2013-10-27','NSRP'),(18562,34908,'2-chloro-N-isopropylacetanilide 1,2-dioxygenase activity','F','Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + O2 + 2 H+ + NADH = 2-chloro-N-isopropylacetamide + catechol + NAD+.','2013-10-27','NSRP'),(18563,34909,'6-hydroxypseudooxynicotine dehydrogenase activity','F','Catalysis of the reaction: 6-hydroxypseudooxynicotine + H2O + OH- = 6-hydroxy-3-succinoylpyridine + 4 H+ + 4 e- + methylamine.','2013-10-27','NSRP'),(18564,34910,'6-hydroxy-3-succinoylpyridine hydrolase activity','F','Catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine.','2013-10-27','NSRP'),(18565,34911,'phthalate 3,4-dioxygenase activity','F','Catalysis of the reaction: phthalate + O2 + NADH + H+ = phthalate 3,4-cis-dihydrodiol + NAD+.','2013-10-27','NSRP'),(18566,34912,'phthalate 3,4-cis-dihydrodiol dehydrogenase activity','F','Catalysis of the reaction: phthalate 3,4-cis-dihydrodiol + NAD+ = 3,4-dihydroxyphthalate + NADH + H+.','2013-10-27','NSRP'),(18567,34914,'trinitrophenol hydride denitratase activity','F','Catalysis of the reaction: trinitrophenol hydride Meisenheimer complex = 2,4-dinitrophenol + nitrite. Trinitrophenol is also known as TNP.','2013-10-27','NSRP'),(18568,34915,'2-methylhexanoyl-CoA C-acetyltransferase activity','F','Catalysis of the reaction: 4-methyl-3-oxooctanoyl-CoA + CoA = acetyl-CoA + 2-methylhexanoyl-CoA.','2013-10-27','NSRP'),(18569,34916,'2-methylhexanoyl-CoA dehydrogenase activity','F','Catalysis of the reaction: 2-methylhexanoyl-CoA = 2-methylhex-2-enoyl-CoA + 2 H+ + e-.','2013-10-27','NSRP'),(18570,34917,'2-methylhex-2-enoyl-CoA hydratase activity','F','Catalysis of the reaction: 2-methylhex-2-enoyl-CoA + H2O = 3-hydroxy-2-methylhexanoyl-CoA.','2013-10-27','NSRP'),(18571,34918,'3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity','F','Catalysis of the reaction: 3-hydroxy-2-methylhexanoyl-CoA = 2-methyl-3-oxohexanoyl-CoA + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18572,34919,'butyryl-CoA 2-C-propionyltransferase activity','F','Catalysis of the reaction: 2-methyl-3-oxohexanoyl-CoA + CoA = propanoyl-CoA + butyryl-CoA.','2013-10-27','NSRP'),(18573,34920,'pyrene dioxygenase activity','F','Catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene.','2013-10-27','NSRP'),(18574,34921,'cis-4,5-dihydroxy-4,5-dihydropyrene dehydrogenase activity','F','Catalysis of the reaction: cis-4,5-dihydroxy-4,5-dihydropyrene = 4,5-dihydroxypyrene + 2 H+ + 2 e-.','2013-10-27','NSRP'),(18575,34922,'4,5-dihydroxypyrene dioxygenase activity','F','Catalysis of the reaction: 4,5-dihydroxypyrene + O2 = phenanthrene-4,5-dicarboxylate + 2 H+.','2013-10-27','NSRP'),(18576,34923,'phenanthrene-4,5-dicarboxylate decarboxylase activity','F','Catalysis of the reaction: phenanthrene-4,5-dicarboxylate + H+ = phenanthrene-4-carboxylate + CO2.','2013-10-27','NSRP'),(18577,34924,'cis-3,4-phenanthrenedihydrodiol-4-carboxylate dehydrogenase activity','F','Catalysis of the reaction: cis-3,4-phenanthrenedihydrodiol-4-carboxylate = 3,4-dihydroxyphenanthrene + H+ + 2 e- + CO2.','2013-10-27','NSRP'),(18578,34925,'pyrene 4,5-monooxygenase activity','F','Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-4,5-oxide + H2O.','2013-10-27','NSRP'),(18579,34926,'pyrene-4,5-epoxide hydrolase activity','F','Catalysis of the reaction: pyrene-4,5-oxide + H2O = trans-4,5-dihydroxy-4,5-dihydropyrene.','2013-10-27','NSRP'),(18580,34927,'pyrene 1,2-monooxygenase activity','F','Catalysis of the reaction: pyrene + O2 + 2 H+ + 2 e- = pyrene-1,2-oxide + H2O.','2013-10-27','NSRP'),(18581,34928,'1-hydroxypyrene 6,7-monooxygenase activity','F','Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-6,7-oxide + H2O.','2013-10-27','NSRP'),(18582,34929,'1-hydroxypyrene 7,8-monooxygenase activity','F','Catalysis of the reaction: 1-hydroxypyrene + O2 + 2 H+ + 2 e- = 1-hydroxypyrene-7,8-oxide + H2O.','2013-10-27','NSRP'),(18583,34930,'1-hydroxypyrene sulfotransferase activity','F','Catalysis of the reaction: 1-hydroxypyrene + XSO3- = 1-pyrenylsulfate + HX.','2013-10-27','NSRP'),(18584,34931,'1-hydroxypyrene methyltransferase activity','F','Catalysis of the reaction: 1-hydroxypyrene + XCH3 = 1-methoxypyrene + HX.','2013-10-27','NSRP'),(18585,34932,'1-methoxypyrene 6,7-monooxygenase activity','F','Catalysis of the reaction: 1-methoxypyrene + O2 + 2 H+ + 2 e- = 1-methoxypyrene-6,7-oxide + H2O.','2013-10-27','NSRP'),(18586,34933,'1-hydroxy-6-methoxypyrene methyltransferase activity','F','Catalysis of the reaction: 1-hydroxy-6-methoxypyrene + XCH3 = 1,6-dimethoxypyrene + HX.','2013-10-27','NSRP'),(18587,34934,'phenanthrene-4-carboxylate dioxygenase activity','F','Catalysis of the reaction: phenanthrene-4-carboxylate + 2 H+ + 2 e- + O2 = cis-3,4-phenanthrenedihydrodiol-4-carboxylate.','2013-10-27','NSRP'),(18588,34935,'tetrachlorobenzene dioxygenase activity','F','Catalysis of the reaction: 2,4-dichlorotoluene + NADH + H+ + O2 = 4,6-dichloro-3-methyl-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+.','2013-10-27','NSRP'),(18589,34936,'4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity','F','Catalysis of the reaction: 4,6-dichloro-3-methylcatechol + O2 = 3,5-dichloro-3-methyl-cis,cis-muconate + 2 H+.','2013-10-27','NSRP'),(18590,34937,'perchlorate reductase activity','F','Catalysis of the reaction: perchlorate + 2 H+ + 2 e- = chlorate + H2O.','2013-10-27','NSRP'),(18591,34938,'pyrrole-2-carboxylate monooxygenase activity','F','Catalysis of the reaction: pryrole-2-carboxylate + NADH + O2 + H+ = 5-hydroxypyrrole-2-carboxylate + NAD+ + H2O.','2013-10-27','NSRP'),(18592,34939,'5-hydroxypyrrole-2-carboxylate tautomerase activity','F','Catalysis of the reaction: 5-hydroxypyrrole-2-carboxylate = 5-oxo-4,5-dihydropyrrole-2-carboxylate.','2013-10-27','NSRP'),(18593,34940,'5-oxo-4,5-dihydropyrrole-2-carboxylate amidase activity','F','Catalysis of the reaction: 5-oxo-4,5-dihydropyrrole-2-carboxylate + 2 H2O = 2-oxoglutarate + NH3.','2013-10-27','NSRP'),(18594,34941,'pyrrole-2-carboxylate decarboxylase activity','F','Catalysis of the reaction: pryrole-2-carboxylate + H+ = pyrrole + CO2.','2013-10-27','NSRP'),(18595,34942,'cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity','F','Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = cis-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi.','2013-10-27','NSRP'),(18596,34943,'trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity','F','Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienoic acid + ATP + CoASH = trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA + AMP + PPi.','2013-10-27','NSRP'),(18597,34944,'3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity','F','Catalysis of the reaction: 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA + NAD+ = 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + NADH+ + H+.','2013-10-27','NSRP'),(18598,34945,'2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity','F','Catalysis of the reaction: 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA + CoASH = 3-isopropylbut-3-enoyl-CoA + propanoyl-CoA.','2013-10-27','NSRP'),(18599,34946,'3-isopropylbut-3-enoyl-CoA thioesterase activity','F','Catalysis of the reaction: 3-isopropylbut-3-enoyl-CoA + H2O = 3-isopropylbut-3-enoic acid + CoASH.','2013-10-27','NSRP'),(18600,34947,'terephthalate decarboxylase activity','F','Catalysis of the reaction: terephthalate + H2O = benzoate + HCO3-.','2013-10-27','NSRP'),(18601,34948,'2,6-dihydroxypseudooxynicotine hydrolase activity','F','Catalysis of the reaction: 2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-methylaminobutyrate.','2013-10-27','NSRP'),(18602,34949,'1,1-dichloroethane reductive dehalogenase activity','F','Catalysis of the reaction: 1,1-dichloroethane + 2 H+ + 2 e- = chloroethane + HCl.','2013-10-27','NSRP'),(18603,34950,'phenylboronic acid monooxygenase activity','F','Catalysis of the reaction: phenylboronic acid + O2 + 2 H+ + 2 e- = phenol + B(OH)3.','2013-10-27','NSRP'),(18604,34951,'o-hydroxylaminobenzoate mutase activity','F','Catalysis of the reaction: o-hydroxylaminobenzoate = 3-hydroxyanthranilate.','2013-10-27','NSRP'),(18605,34952,'malonate semialdehyde decarboxylase activity','F','Catalysis of the reaction: malonate semialdehyde + H+ = acetaldehyde + CO2.','2013-10-27','NSRP'),(18606,34953,'perillyl-CoA hydratase activity','F','Catalysis of the reaction: perillyl-CoA + H2O = 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA.','2013-10-27','NSRP'),(18607,34954,'diphenyl ether 2,3-dioxygenase activity','F','Catalysis of the reaction: diphenyl ether + O2 = 2,3-dihydroxydiphenyl ether.','2013-10-27','NSRP'),(18608,34955,'2,3-dihydroxydiphenyl ether dioxygenase activity','F','Catalysis of the reaction: 2,3-dihydroxydiphenyl ether + O2 + H2O = 2-hydroxymuconate + phenol.','2013-10-27','NSRP'),(18609,34956,'diphenyl ether 1,2-dioxygenase activity','F','Catalysis of the reaction: diphenyl ether + NADH + O2 + H+ = phenol + catechol + NAD+.','2013-10-27','NSRP'),(18610,34957,'3-nitrophenol nitroreductase activity','F','Catalysis of the reaction: 3-nitrophenol + 2 NADH + 2 H+ = 3-hydroxyaminophenol + 2 NAD+ + H2O.','2013-10-27','NSRP'),(18611,34958,'aminohydroquinone monooxygenase activity','F','Catalysis of the reaction: aminohydroquinone + 2 e- + 2 H+ + 1/2 O2 = 1,2,4-benzenetriol + NH3.','2013-10-27','NSRP'),(18612,34959,'endothelin maturation','P','The process leading to the attainment of the full functional capacity of endothelin by conversion of Big-endothelin substrate into mature endothelin.','2013-10-27','NSRP'),(18613,34963,'box C/D snoRNA processing','P','Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript into a mature box C/D snoRNA.','2013-10-27','NSRP'),(18614,34964,'box H/ACA snoRNA processing','P','Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript into a mature box H/ACA snoRNA.','2013-10-27','NSRP'),(18615,34965,'intronic box C/D snoRNA processing','P','Any process involved in the conversion of a primary box C/D type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box C/D snoRNA.','2013-10-27','NSRP'),(18616,34966,'intronic box H/ACA snoRNA processing','P','Any process involved in the conversion of a primary box H/ACA type small nucleolar RNA (snoRNA) transcript that resides within, and is processed from, the intron of a pre-mRNA into a mature box H/ACA snoRNA.','2013-10-27','NSRP'),(18617,34967,'Set3 complex','C','A histone deacetylase complex that is involved in transcriptional regulation. In S. cerevisiae, this complex consists of Set3p, Snt1p, Hos4p, Sif2p, Cpr1p, Hos2p, and Hst1p.','2013-10-27','NSRP'),(18618,34968,'histone lysine methylation','P','The modification of a histone by addition of a methyl group to a lysine residue.','2013-10-27','NSRP'),(18619,34969,'histone arginine methylation','P','The modification of a histone by addition of a methyl group to an arginine residue.','2013-10-27','NSRP'),(18620,34970,'histone H3-R2 methylation','P','The modification of histone H3 by addition of a methyl group to arginine at position 2 of the histone.','2013-10-27','NSRP'),(18621,34971,'histone H3-R17 methylation','P','The modification of histone H3 by addition of a methyl group to arginine at position 17 of the histone.','2013-10-27','NSRP'),(18622,34972,'histone H3-R26 methylation','P','The modification of histone H3 by addition of a methyl group to arginine at position 26 of the histone.','2013-10-27','NSRP'),(18623,34973,'Sid2-Mob1 complex','C','A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex.','2013-10-27','NSRP'),(18624,34974,'Swi5-Swi2 complex','C','A protein complex involved that contains proteins known in Schizosaccharomyces as Swi5 monomers and Swi2, and is involved in mating type switching.','2013-10-27','NSRP'),(18625,34975,'protein folding in endoplasmic reticulum','P','A protein folding process that takes place in the endoplasmic reticulum (ER). Secreted, plasma membrane and organelle proteins are folded in the ER, assisted by chaperones and foldases (protein disulphide isomerases), and additional factors required for optimal folding (ATP, Ca2+ and an oxidizing environment to allow disulfide bond formation).','2013-10-27','NSRP'),(18626,34976,'response to endoplasmic reticulum stress','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating endoplasmic reticulum (ER) stress. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.','2013-10-27','NSRP'),(18627,34977,'ABIN2-NFKB1-MAP3K8 complex','C','A protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages.','2013-10-27','NSRP'),(18628,34978,'PDX1-PBX1b-MRG1 complex','C','A protein complex that contains the homeodomain proteins PDX1, PBX1b and MRG1 (MEIS2) and is involved in the transcriptional regulation of pancreatic acinar cell-specific genes.','2013-10-27','NSRP'),(18629,34979,'NAD-dependent protein deacetylase activity','F','Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.','2013-10-27','NSRP'),(18630,34980,'FHL2-CREB complex','C','A protein complex that contains CREB and FHL2, and is involved in transcriptional regulation.','2013-10-27','NSRP'),(18631,34981,'FHL3-CREB complex','C','A protein complex that contains CREB and FHL3, and is involved in transcriptional regulation.','2013-10-27','NSRP'),(18632,34982,'mitochondrial protein processing','P','The peptide cleavage of mitochondrial proteins, including cleavage contributing to their import.','2013-10-27','NSRP'),(18633,34983,'peptidyl-lysine deacetylation','P','The removal of an acetyl group from an acetylated lysine residue in a peptide or protein.','2013-10-27','NSRP'),(18634,34985,'Ecsit-NDUFAF1 complex','C','Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed.','2013-10-27','NSRP'),(18635,34986,'iron chaperone activity','F','Assists in the delivery of iron ions to target proteins or compartments.','2013-10-27','NSRP'),(18636,34987,'immunoglobulin receptor binding','F','Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.','2013-10-27','NSRP'),(18637,34988,'Fc-gamma receptor I complex binding','F','Interacting selectively and non-covalently with one or more specific sites on the Fc-gamma receptor I complex. The complex functions primarily as an activating receptor for IgG.','2013-10-27','NSRP'),(18638,34989,'GTP-Ral binding','F','Interacting selectively and non-covalently with the GTP-bound form of the Ral protein.','2012-03-14','NSRP'),(18639,34990,'nuclear mitotic cohesin complex','C','A cohesin complex that mediates sister chromatid cohesion in the nucleus during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.','2013-10-27','NSRP'),(18640,34991,'nuclear meiotic cohesin complex','C','A cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the meiotic cohesin complex.','2013-10-27','NSRP'),(18641,34992,'microtubule organizing center attachment site','C','A region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches; protein complexes embedded in the nuclear envelope mediate direct or indirect linkages between the microtubule cytoskeleton and the nuclear envelope.','2013-10-27','NSRP'),(18642,34993,'SUN-KASH complex','C','A protein complex that spans the nuclear outer and inner membranes, thereby linking the major cytoplasmic cytoskeleton elements to the nuclear lumen; the complex is conserved in eukaryotes and contains proteins with SUN and KASH domains.','2013-10-27','NSRP'),(18643,34994,'microtubule organizing center attachment site organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center attachment site. A microtubule organizing center attachment site is a region of the nuclear envelope to which a microtubule organizing center (MTOC) attaches.','2013-10-27','NSRP'),(18644,34995,'SC5b-7 complex','C','A protein complex that consist of complement components C5b6 and C7 stably inserted in a cell membrane. Formation of the SC5b-7 complex is the first phase of membrane attack complex assembly.','2013-10-27','NSRP'),(18645,34996,'RasGAP-Fyn-Lyn-Yes complex','C','A protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation.','2013-10-27','NSRP'),(18646,34997,'alphav-beta5 integrin-vitronectin complex','C','A protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin.','2013-10-27','NSRP'),(18647,34998,'oligosaccharyltransferase I complex','C','An oligosaccharyltransferase (OST) complex that contains at least seven polypeptides and is the major OST complex in mammalian cells. Of the three forms of mammalian OST complex identified, the OSTI complex has the weakest affinity for ribosomes.','2013-10-27','NSRP'),(18648,34999,'oligosaccharyltransferase II complex','C','An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma. Of the three forms of mammalian OST complexes identified, the OSTII complex has intermediate affinity for ribosomes.','2013-10-27','NSRP'),(18649,35000,'oligosaccharyltransferase III complex','C','An oligosaccharyltransferase (OST) complex that contains the seven polypeptides found in OST complex I, plus heterotrimeric Sec61alpha-beta-gamma and the tetrameric TRAP complex. Of the three forms of mammalian OST complexes identified, the OSTIII complex has the strongest affinity for ribosomes.','2013-10-27','NSRP'),(18650,35001,'dorsal trunk growth, open tracheal system','P','Growth of epithelial tubes that originate from pits in an open tracheal system and grow towards each other to meet and form a continuous open tube called the dorsal trunk. The dorsal trunk extends from the anterior spiracle to the posterior spiracle of the larva and forms the main airway of the insect tracheal system.','2013-10-27','NSRP'),(18651,35002,'liquid clearance, open tracheal system','P','The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system.','2013-10-27','NSRP'),(18652,35003,'subapical complex','C','The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.','2013-10-27','NSRP'),(18653,35004,'phosphatidylinositol 3-kinase activity','F','Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3\' position of the inositol ring.','2013-10-27','NSRP'),(18654,35005,'1-phosphatidylinositol-4-phosphate 3-kinase activity','F','Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(18655,35006,'melanization defense response','P','The blackening of the wounded area of the cuticle or the surface of invading pathogens, parasites or parasitoids, resulting from a proteolytic cascade leading to the de novo synthesis and deposition of melanin.','2013-10-27','NSRP'),(18656,35007,'regulation of melanization defense response','P','Any process that affects the rate, extent or location of the melanization defense response during injury or invasion.','2013-10-27','NSRP'),(18657,35008,'positive regulation of melanization defense response','P','Any process that increases the rate or extent of the melanization defense response during injury or invasion.','2013-10-27','NSRP'),(18658,35009,'negative regulation of melanization defense response','P','Any process that reduces the rate or extent of the melanization defense response. This regulation is critical to limit melanization to the site of injury or infection.','2013-10-27','NSRP'),(18659,35010,'encapsulation of foreign target','P','Events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization.','2013-10-27','NSRP'),(18660,35011,'melanotic encapsulation of foreign target','P','Formation of a multilayered, melanized sheath of cells around a foreign invader.','2013-10-27','NSRP'),(18661,35012,'polytene chromosome, telomeric region','C','The terminal region of a polytene chromosome.','2013-10-27','NSRP'),(18662,35013,'myosuppressin receptor activity','F','Combining with the peptide myosuppressin to initiate a change in cell activity.','2013-10-27','NSRP'),(18663,35014,'phosphatidylinositol 3-kinase regulator activity','F','Modulates the activity of any of the phosphatidylinositol 3-kinases (PI3Ks). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates.','2013-10-27','NSRP'),(18664,35015,'elongation of arista core','P','The increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions.','2013-10-27','NSRP'),(18665,35016,'elongation of arista lateral','P','The increase in length of the aristal laterals. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions.','2013-10-27','NSRP'),(18666,35017,'cuticle pattern formation','P','The regionalization process that gives rise to the patterns of cell differentiation in the cuticle.','2013-10-27','NSRP'),(18667,35018,'adult chitin-based cuticle pattern formation','P','The process that gives rise to the patterns of cell differentiation that will arise in the chitin-based adult cuticle. An example of this process is adult chitin-based cuticle pattern formation in Drosophila melanogaster.','2013-10-27','NSRP'),(18668,35019,'somatic stem cell maintenance','P','The process in which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.','2013-10-27','NSRP'),(18669,35020,'regulation of Rac protein signal transduction','P','Any process that modulates the frequency, rate or extent of Rac protein signal transduction.','2013-10-27','NSRP'),(18670,35021,'negative regulation of Rac protein signal transduction','P','Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction.','2013-10-27','NSRP'),(18671,35022,'positive regulation of Rac protein signal transduction','P','Any process that activates or increases the frequency, rate or extent of Rac protein signal transduction.','2013-10-27','NSRP'),(18672,35023,'regulation of Rho protein signal transduction','P','Any process that modulates the frequency, rate or extent of Rho protein signal transduction.','2013-10-27','NSRP'),(18673,35024,'negative regulation of Rho protein signal transduction','P','Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.','2013-10-27','NSRP'),(18674,35025,'positive regulation of Rho protein signal transduction','P','Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.','2013-10-27','NSRP'),(18675,35026,'leading edge cell differentiation','P','The process in which relatively unspecialized cells acquire specialized structural and/or functional features of leading edge cells, cells at the front of a migrating epithelial sheet.','2013-10-27','NSRP'),(18676,35027,'leading edge cell fate commitment','P','The commitment of cells to leading edge cell fate and their capacity to differentiate into leading edge cells. Leading edge cells are found at the front of a migrating epithelial sheet.','2013-10-27','NSRP'),(18677,35028,'leading edge cell fate determination','P','The process in which a cell becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(18678,35029,'dorsal closure, leading edge cell fate commitment','P','The commitment of cells to leading edge cell fate during dorsal closure. Leading edge cells are the dorsal-most cells of the migrating epidermis.','2013-10-27','NSRP'),(18679,35032,'phosphatidylinositol 3-kinase complex, class III','C','A complex containing a heterodimer of a catalytic Class III phosphoinositide 3-kinase (PI3K) subunit bound to a regulatory (adaptor) subunit. Class III PI3Ks have a substrate specificity restricted to phosphatidylinositol (PI).','2013-10-27','NSRP'),(18680,35033,'histone deacetylase regulator activity','F','Modulates the activity of histone deacetylase.','2013-10-27','NSRP'),(18681,35034,'histone acetyltransferase regulator activity','F','Modulates the activity of histone acetyltransferase.','2013-10-27','NSRP'),(18682,35035,'histone acetyltransferase binding','F','Interacting selectively and non-covalently with the enzyme histone acetyltransferase.','2013-10-27','NSRP'),(18683,35036,'sperm-egg recognition','P','The initial contact step made between the sperm plasma membrane and outer layer of the egg during fertilization.','2013-10-27','NSRP'),(18684,35037,'sperm entry','P','An endocytosis process that results in penetration of the egg shell through the micropyle (a specialized anterior opening in the vitelline envelope) and entry of the entire sperm, including the surrounding plasma membrane and the sperm tail, into the egg cytoplasm. This step in fertilization is seen in Drosophila, where a plasma membrane fusion event between the sperm and the egg does not occur.','2013-10-27','NSRP'),(18685,35038,'female pronucleus assembly','P','Assembly of the haploid nucleus of the unfertilized egg.','2013-10-27','NSRP'),(18686,35039,'male pronucleus assembly','P','The conversion at fertilization of the inactive sperm nucleus into a male pronucleus with its chromosomes processed for the first zygotic division.','2013-10-27','NSRP'),(18687,35040,'sperm nuclear envelope removal','P','Removal of the sperm nuclear envelope, allowing entry of maternal factors into the sperm nucleus.','2013-10-27','NSRP'),(18688,35041,'sperm chromatin decondensation','P','Unwinding of the condensed nuclear chromatin of an inactive sperm nucleus.','2013-10-27','NSRP'),(18689,35042,'fertilization, exchange of chromosomal proteins','P','Replacement of sperm-specific chromosomal proteins with somatic histones, to allow the paternal genome to acquire a nucleosomal chromatin organization compatible with nuclear activity.','2013-10-27','NSRP'),(18690,35043,'male pronuclear envelope synthesis','P','Assembly of a nuclear envelope containing nuclear pores and a lamina around the male pronucleus, the final step in sperm pronuclear formation.','2013-10-27','NSRP'),(18691,35044,'sperm aster formation','P','Formation and organization of an aster composed of microtubule arrays originating from the sperm basal body and extending virtually to the egg periphery. The sperm aster ensures the appropriate positioning of the male and female pronuclei.','2013-10-27','NSRP'),(18692,35045,'sperm plasma membrane disassembly','P','The gradual disintegration of the sperm plasma membrane following insemination. This process is seen in Drosophila after entry of the entire sperm, surrounded by its plasma membrane, into the egg.','2013-10-27','NSRP'),(18693,35046,'pronuclear migration','P','The directed movement of the male and female pronuclei towards each other prior to their fusion.','2013-10-27','NSRP'),(18694,35047,'centrosomal and pronuclear rotation','P','The rotation of centrosomes and associated pronuclei in one-cell embryos such as those of Caenorhabditis elegans, occurring as a transition between pronuclear migration and pronuclear fusion.','2013-10-27','NSRP'),(18695,35048,'splicing factor protein import into nucleus','P','The directed movement of a pre-mRNA splicing factor from the cytoplasm into the nucleus, across the nuclear membrane.','2013-10-27','NSRP'),(18696,35049,'juvenile hormone acid methyltransferase activity','F','Catalysis of the transfer of a methyl group to juvenile hormone acid.','2013-10-27','NSRP'),(18697,35050,'embryonic heart tube development','P','The process whose specific outcome is the progression of the embryonic heart tube over time, from its formation to the mature structure. The heart tube forms as the heart rudiment from the heart field.','2013-10-27','NSRP'),(18698,35051,'cardiocyte differentiation','P','The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell that will form part of the cardiac organ of an individual.','2013-10-27','NSRP'),(18699,35052,'dorsal vessel aortic cell fate commitment','P','The commitment of dorsal vessel cardioblast cells to an aortic cell fate and their capacity to differentiate into aortic cells. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18700,35053,'dorsal vessel heart proper cell fate commitment','P','The commitment of dorsal vessel cardioblast cells to a heart proper cell fate and their capacity to differentiate into heart cells. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18701,35054,'embryonic heart tube anterior/posterior pattern specification','P','The establishment, maintenance and elaboration of cell differentiation that results in the anterior/posterior subdivision of the embryonic heart tube. In Drosophila this results in subdivision of the dorsal vessel into to the posterior heart proper and the anterior aorta.','2013-10-27','NSRP'),(18702,35058,'nonmotile primary cilium assembly','P','The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules.','2013-10-27','NSRP'),(18703,35059,'RCAF complex','C','A protein complex that facilitates the assembly of nucleosomes on to newly synthesized DNA. In Drosophila, the complex comprises ASF1 and histones H3 and H4.','2013-10-27','NSRP'),(18704,35060,'brahma complex','C','A SWI/SNF-type complex that contains the ATPase product of the Drosophila brahma gene, or an ortholog thereof.','2013-10-27','NSRP'),(18705,35061,'interchromatin granule','C','A class of nuclear body measuring 20-25 nm in diameter and distributed throughout the interchromatin space, linked together by thin fibrils. They are believed to be storage centers for various snRNAs, snRNPs, serine/arginine-rich proteins and RNA polymerase II. A typical mammalian cell contains 25-50 clusters of interchromatin granules. Interchromatin granule clusters do not contain the heterogeneous nuclear RNA-binding proteins (hnRNPs).','2013-10-27','NSRP'),(18706,35062,'omega speckle','C','A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs).','2013-10-27','NSRP'),(18707,35063,'nuclear speck organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of nuclear specks, a class of nuclear body in which splicing factors are localized.','2013-10-27','NSRP'),(18708,35064,'methylated histone residue binding','F','Interacting selectively and non-covalently with a methylated residue on a histone protein. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.','2013-10-27','NSRP'),(18709,35065,'regulation of histone acetylation','P','Any process that modulates the frequency, rate or extent of the addition of an acetyl group to a histone protein.','2013-10-27','NSRP'),(18710,35066,'positive regulation of histone acetylation','P','Any process that activates or increases the frequency, rate or extent of the addition of an acetyl group to a histone protein.','2013-10-27','NSRP'),(18711,35067,'negative regulation of histone acetylation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.','2013-10-27','NSRP'),(18712,35068,'micro-ribonucleoprotein complex','C','A complex containing both protein and micro-RNA (miRNA) molecules. miRNAs are approximately 22 nucleotide noncoding RNAs derived from endogenous genes; they are processed from the stem of a longer hairpin like structure termed a pre-miRNA.','2013-10-27','NSRP'),(18713,35069,'larval midgut histolysis','P','The stage-specific break down of the larval midgut during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly.','2013-10-27','NSRP'),(18714,35070,'salivary gland histolysis','P','The stage-specific break down of the larval salivary glands during Drosophila metamorphosis, to allow replacement of larval structures by tissues and structures that form the adult fly.','2013-10-27','NSRP'),(18715,35071,'salivary gland cell autophagic cell death','P','The stage-specific programmed cell death of salivary gland cells during salivary gland histolysis.','2013-10-27','NSRP'),(18716,35072,'ecdysone-mediated induction of salivary gland cell autophagic cell death','P','Any process induced by ecdysone that directly activates salivary gland programmed cell death during salivary gland histolysis.','2013-10-27','NSRP'),(18717,35073,'pupariation','P','The onset of prepupal development when the larval stops crawling, everts its spiracles and the larval cuticle becomes the puparium or pupal case that surrounds the organism for the duration of metamorphosis.','2013-10-27','NSRP'),(18718,35074,'pupation','P','The act of becoming a pupa, a resting stage in the life cycle of organisms with complete metamorphosis. This event marks the end of the prepupal period and the beginning of the pupal period.','2013-10-27','NSRP'),(18719,35075,'response to ecdysone','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus.','2013-10-27','NSRP'),(18720,35076,'ecdysone receptor-mediated signaling pathway','P','The series of molecular signals generated by ecdysone binding to the ecdysone receptor complex.','2013-10-27','NSRP'),(18721,35077,'ecdysone-mediated polytene chromosome puffing','P','The decondensing (loosening) and swelling of the chromosomal sites of hormone-responsive genes on polytene chromosomes in response to increased production of the steroid hormone 20-hydroxyecdysone (ecdysone) in Drosophila larvae approaching pupation.','2013-10-27','NSRP'),(18722,35078,'induction of programmed cell death by ecdysone','P','Any process induced by the steroid hormone 20-hydroxyecdysone (ecdysone) that directly activates any of the steps required for programmed cell death.','2013-10-27','NSRP'),(18723,35079,'polytene chromosome puffing','P','The decondensing (loosening) and swelling of the chromosomal sites of target genes on polytene chromosomes following response to a stimulus, to facilitate sudden bursts of transcriptional activity in response to transient environmental signals.','2013-10-27','NSRP'),(18724,35080,'heat shock-mediated polytene chromosome puffing','P','The decondensing (loosening) and swelling of the chromosomal sites of heat shock genes on polytene chromosomes in response to a heat shock stimulus.','2013-10-27','NSRP'),(18725,35081,'induction of programmed cell death by hormones','P','Any process induced by hormones that directly activates any of the steps required for programmed cell death.','2013-10-27','NSRP'),(18726,35082,'axoneme assembly','P','The assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements.','2013-10-27','NSRP'),(18727,35083,'cilium axoneme assembly','P','The assembly of a the bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements.','2013-10-27','NSRP'),(18728,35084,'flagellar axoneme assembly','P','The assembly of the bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements.','2013-03-26','NSRP'),(18729,35085,'cilium axoneme','C','The bundle of microtubules and associated proteins that forms the core of cilia in eukaryotic cells and is responsible for their movements.','2013-10-27','NSRP'),(18730,35086,'flagellar axoneme','C','The bundle of microtubules and associated proteins that forms the core of flagellar in eukaryotic cells and is responsible for their movements.','2012-03-14','NSRP'),(18731,35087,'siRNA loading onto RISC involved in RNA interference','P','The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.','2013-10-27','NSRP'),(18732,35088,'establishment or maintenance of apical/basal cell polarity','P','Any cellular process that results in the specification, formation or maintenance polarization of a cell\'s architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.','2013-10-27','NSRP'),(18733,35089,'establishment of apical/basal cell polarity','P','The specification and formation of the polarity of a cell along its apical/basal axis.','2013-10-27','NSRP'),(18734,35090,'maintenance of apical/basal cell polarity','P','Retaining the established polarization of a cell along its apical/basal axis.','2013-10-27','NSRP'),(18735,35091,'phosphatidylinositol binding','F','Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.','2013-10-27','NSRP'),(18736,35092,'sperm chromatin condensation','P','The progressive compaction of the spermatid chromatin so that it reaches a level of condensation that is not compatible with nuclear activities such as transcription or DNA replication.','2013-10-27','NSRP'),(18737,35093,'spermatogenesis, exchange of chromosomal proteins','P','The replacement of somatic histones within sperm chromatin with sperm-specific histones or protamines with unique DNA-binding properties, resulting in condensation of the sperm chromatin.','2013-10-27','NSRP'),(18738,35094,'response to nicotine','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nicotine stimulus.','2013-10-27','NSRP'),(18739,35095,'behavioral response to nicotine','P','Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.','2013-10-27','NSRP'),(18740,35096,'larval midgut cell programmed cell death','P','The stage-specific programmed cell death of cells of the larval midgut, during histolysis of the larval organ.','2013-10-27','NSRP'),(18741,35097,'histone methyltransferase complex','C','A multimeric complex that is able to catalyze the addition of methyl groups to histone proteins.','2013-10-27','NSRP'),(18742,35098,'ESC/E(Z) complex','C','A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.','2013-10-27','NSRP'),(18743,35099,'hemocyte migration','P','The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo.','2013-10-27','NSRP'),(18744,35100,'ecdysone binding','F','Interacting selectively and non-covalently with 20-hydroxyecdysone (ecdysone). Ecdysone is an ecdysteroid produced by the prothoracic glands of immature insects and the ovaries of adult females, which stimulates growth and molting.','2013-10-27','NSRP'),(18745,35101,'FACT complex','C','An abundant nuclear complex, which was originally identified in mammalian systems as a factor required for transcription elongation on chromatin templates. The FACT complex has been shown to destablilize the interaction between the H2A/H2B dimer and the H3/H4 tetramer of the nucleosome, thus reorganizing the structure of the nucleosome. In this way, the FACT complex may play a role in DNA replication and other processes that traverse the chromatin, as well as in transcription elongation. FACT is composed of two proteins that are evolutionarily conserved in all eukaryotes and homologous to mammalian Spt16 and SSRP1. In metazoans, the SSRP1 homolog contains an HMG domain; however in fungi and protists, it does not. For example, in S. cerevisiae the Pob3 protein is homologous to SSRP1, but lacks the HMG chromatin binding domain. Instead, the yFACT complex of Spt16p and Pob3p, binds to nucleosomes where multiple copies of the HMG-domain containing protein Nhp6p have already bound, but Nhp6p does not form a stable complex with the Spt16p/Pob3p heterodimer.','2013-10-27','NSRP'),(18746,35102,'PRC1 complex','C','An insect multiprotein complex containing the products of many of the Polycomb Group genes including Polycomb, Posterior sex combs, polyhomeotic and Sex comb on midleg. The Polycomb Group proteins are required for stable long-term maintenance of transcriptionally repressed states and the PRC1 complex directly antagonizes ATP-dependent remodeling of nucleosomal arrays.','2013-10-27','NSRP'),(18747,35103,'sterol regulatory element binding protein cleavage','P','The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus to upregulate transcription of target genes, in response to altered levels of one or more lipids.','2013-10-27','NSRP'),(18748,35104,'positive regulation of transcription via sterol regulatory element binding','P','The process in which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs in the promoters of target genes.','2012-03-14','NSRP'),(18749,35105,'sterol regulatory element binding protein import into nucleus','P','The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus, across the nuclear membrane, in response to altered levels of one or more lipids. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes.','2013-10-27','NSRP'),(18750,35106,'operant conditioning','P','Learning to anticipate future events on the basis of past experience with the consequences of one\'s own behavior.','2013-10-27','NSRP'),(18751,35107,'appendage morphogenesis','P','The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.','2013-10-27','NSRP'),(18752,35108,'limb morphogenesis','P','The process in which the anatomical structures of a limb are generated and organized. A limb is a paired appendage of a tetrapod used for locomotion or grasping.','2013-10-27','NSRP'),(18753,35109,'imaginal disc-derived limb morphogenesis','P','OBSOLETE. The process in which the anatomical structures of limbs that are derived from an imaginal disc are generated and organized. A limb is an appendage of an animal used for locomotion or grasping. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18754,35110,'leg morphogenesis','P','OBSOLETE. The process in which the anatomical structures of a leg are generated and organized. A leg is a limb on which an animal walks and stands.','2013-10-27','NSRP'),(18755,35111,'leg joint morphogenesis','P','OBSOLETE. The process in which the anatomical structures of a leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. One example is the knee, which separates the leg tibia and femur.','2013-10-27','NSRP'),(18756,35112,'genitalia morphogenesis','P','The process in which the anatomical structures of genitalia are generated and organized. The genitalia are the organs of reproduction or generation, external and internal.','2013-10-27','NSRP'),(18757,35113,'embryonic appendage morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.','2013-10-27','NSRP'),(18758,35114,'imaginal disc-derived appendage morphogenesis','P','The process in which the anatomical structures of appendages are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism.','2013-10-27','NSRP'),(18759,35115,'embryonic forelimb morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.','2013-10-27','NSRP'),(18760,35116,'embryonic hindlimb morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the hindlimbs are generated and organized. The hindlimbs are the posterior limbs of an animal.','2013-10-27','NSRP'),(18761,35117,'embryonic arm morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the arm are generated and organized. In humans, the arms are the two upper limbs of the body from the shoulder to the hand.','2012-03-14','NSRP'),(18762,35118,'embryonic pectoral fin morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.','2013-10-27','NSRP'),(18763,35119,'embryonic pelvic fin morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion.','2013-10-27','NSRP'),(18764,35120,'post-embryonic appendage morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of an appendage are generated and organized. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.','2013-10-27','NSRP'),(18765,35121,'tail morphogenesis','P','OBSOLETE. The process in which the anatomical structures of the tail are generated and organized. The tail is the hindmost part of some animals.','2013-10-27','NSRP'),(18766,35122,'embryonic medial fin morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming.','2013-10-27','NSRP'),(18767,35123,'embryonic dorsal fin morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins.','2013-10-27','NSRP'),(18768,35124,'embryonic caudal fin morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion.','2013-10-27','NSRP'),(18769,35125,'embryonic anal fin morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the embryonic anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming.','2013-10-27','NSRP'),(18770,35126,'post-embryonic genitalia morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the genitalia are generated and organized.','2013-10-27','NSRP'),(18771,35127,'post-embryonic limb morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.','2013-10-27','NSRP'),(18772,35128,'post-embryonic forelimb morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an organism.','2013-10-27','NSRP'),(18773,35129,'post-embryonic hindlimb morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the hindlimb are generated and organized.','2013-10-27','NSRP'),(18774,35130,'post-embryonic pectoral fin morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.','2013-10-27','NSRP'),(18775,35131,'post-embryonic pelvic fin morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the pelvic fin are generated and organized. The pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion.','2013-10-27','NSRP'),(18776,35132,'post-embryonic medial fin morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the medial fin are generated and organized. Medial fins are unpaired fins of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming.','2013-10-27','NSRP'),(18777,35133,'post-embryonic caudal fin morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the caudal fin are generated and organized. The caudal fin is an unpaired medial fin mounted at the caudal end of the fish and is the main fin used for propulsion.','2013-10-27','NSRP'),(18778,35134,'post-embryonic dorsal fin morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins.','2013-10-27','NSRP'),(18779,35135,'post-embryonic anal fin morphogenesis','P','The process, occurring after embryonic development, by which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming.','2013-10-27','NSRP'),(18780,35136,'forelimb morphogenesis','P','The process in which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.','2013-10-27','NSRP'),(18781,35137,'hindlimb morphogenesis','P','The process in which the anatomical structures of the hindlimb are generated and organized.','2013-10-27','NSRP'),(18782,35138,'pectoral fin morphogenesis','P','The process in which the anatomical structures of the pectoral fin are generated and organized. Pectoral fins are bilaterally paired fins mounted laterally and located behind the gill covers of fish. These fins are used for lateral mobility and propulsion.','2013-10-27','NSRP'),(18783,35139,'pelvic fin morphogenesis','P','The process in which the anatomical structures of the pelvic fin are generated and organized. Pelvic fins are bilaterally paired fins mounted in a ventral-lateral position on most fish. These fins are used primarily for lateral mobility and propulsion.','2013-10-27','NSRP'),(18784,35140,'arm morphogenesis','P','The process in which the anatomical structures of the arm are generated and organized. In humans, the arms are the two upper limbs of the body from the shoulder to the hand.','2012-03-14','NSRP'),(18785,35141,'medial fin morphogenesis','P','The process in which the anatomical structures of the medial fin are generated and organized. A medial fin is an unpaired fin of fish, usually located dorsomedially or ventromedially and primarily used for stability while swimming.','2013-10-27','NSRP'),(18786,35142,'dorsal fin morphogenesis','P','The process in which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins.','2013-10-27','NSRP'),(18787,35143,'caudal fin morphogenesis','P','The process in which the anatomical structures of the caudal fin are generated and organized. A caudal fin is an unpaired medial fin mounted at the caudal end of the fish, and is the main fin used for propulsion.','2013-10-27','NSRP'),(18788,35144,'anal fin morphogenesis','P','The process in which the anatomical structures of the anal fin are generated and organized. An anal fin is an unpaired medial fin on the ventral aspect near the caudal end of a fish, which provides lateral stability while swimming.','2013-10-27','NSRP'),(18789,35145,'exon-exon junction complex','C','A multi-subunit complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay.','2013-10-27','NSRP'),(18790,35146,'tube fusion','P','The joining of specific branches of a tubular system to form a continuous network.','2013-10-27','NSRP'),(18791,35147,'branch fusion, open tracheal system','P','Fusing of specific tracheal branches in an open tracheal system to branches from neighboring hemisegments to form a continuous tracheal network. Branch fusion is mediated by individual cells at the tip of each branch, which contact a similar cell and undergo a coordinated series of morphogenetic events that create a bicellular fusion joint.','2013-10-27','NSRP'),(18792,35148,'tube formation','P','Creation of the central hole of a tube in an anatomical structure through which gases and/or liquids flow.','2013-10-27','NSRP'),(18793,35149,'lumen formation, open tracheal system','P','Creation of the central hole of a tube in an open tracheal system through which gases flow.','2013-10-27','NSRP'),(18794,35150,'regulation of tube size','P','Ensuring that a tube is of the correct length and diameter. Tube size must be maintained not only during tube formation, but also throughout development and in some physiological processes.','2013-10-27','NSRP'),(18795,35151,'regulation of tube size, open tracheal system','P','Ensuring that an epithelial tube in an open tracheal system is of the correct length and diameter. Tracheal tubes undergo highly regulated tube-size increases during development, expanding up to 40 times their initial size by the end of larval life. Tube size appears to be controlled by regulation of apical membrane expansion and secretion, rather than by changes in cell number, size or shape.','2013-10-27','NSRP'),(18796,35152,'regulation of tube architecture, open tracheal system','P','Ensuring that tracheal cells form and maintain tubular structures with the correct size and shape for their position in the network. This is essential for efficient flow of gases through the tracheal network.','2013-10-27','NSRP'),(18797,35153,'epithelial cell type specification, open tracheal system','P','Allocation of epithelial cells within each migrating branch in an open tracheal system to distinct tracheal cell fates. During the migration phase each branch forms a well-defined number of cell types (including fusion cells, terminal cells and branch cells) at precise positions.','2013-10-27','NSRP'),(18798,35154,'terminal cell fate specification, open tracheal system','P','The process in which a cell in an open tracheal system becomes capable of differentiating autonomously into a terminal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Terminal cells send long and bifurcated hollow branches toward target tissues to allow oxygen exchange.','2013-10-27','NSRP'),(18799,35155,'negative regulation of terminal cell fate specification, open tracheal system','P','Any process that restricts, stops or prevents a cell from adopting a terminal cell fate in an open tracheal system. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates.','2013-10-27','NSRP'),(18800,35156,'fusion cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into a fusion cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. Fusion cells allow the interconnection of adjacent tracheal metameres during tracheal tube fusion.','2013-10-27','NSRP'),(18801,35157,'negative regulation of fusion cell fate specification','P','Any process that restricts, stops or prevents a cell from adopting a fusion cell fate. Once the terminal and fusion fates have been correctly induced, inhibitory feedback loops prevent the remaining branch cells from assuming similar fates.','2013-10-27','NSRP'),(18802,35158,'regulation of tube diameter, open tracheal system','P','Ensuring that a tube in an open tracheal system is of the correct diameter. When primary branches form their lumens are small (less than 2 micrometers) in caliber and must undergo regulated expansion during larval life to reach their mature size.','2013-10-27','NSRP'),(18803,35159,'regulation of tube length, open tracheal system','P','Ensuring that a tube in an open tracheal system is of the correct length.','2013-10-27','NSRP'),(18804,35160,'maintenance of epithelial integrity, open tracheal system','P','Ensuring that tracheal tubes in an open tracheal system maintain their epithelial structure during the cell shape changes and movements that occur during the branching process.','2013-10-27','NSRP'),(18805,35161,'imaginal disc lineage restriction','P','Formation and/or maintenance of a lineage boundary between compartments in an imaginal disc that cells cannot cross, thus separating the populations of cells in each compartment.','2013-10-27','NSRP'),(18806,35162,'embryonic hemopoiesis','P','The stages of blood cell formation that take place within the embryo.','2013-10-27','NSRP'),(18807,35163,'embryonic hemocyte differentiation','P','The process in which a relatively unspecialized cell derived from the embryonic head mesoderm acquires the specialized features of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen.','2013-10-27','NSRP'),(18808,35164,'embryonic plasmatocyte differentiation','P','The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte.','2013-10-27','NSRP'),(18809,35165,'embryonic crystal cell differentiation','P','The process in which an embryonic mesoderm-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph.','2013-10-27','NSRP'),(18810,35166,'post-embryonic hemopoiesis','P','The stages of blood cell formation that take place after completion of embryonic development.','2013-10-27','NSRP'),(18811,35167,'larval lymph gland hemopoiesis','P','The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.','2013-10-27','NSRP'),(18812,35168,'larval lymph gland hemocyte differentiation','P','The process in which a relatively unspecialized cell derived from the larval lymph gland acquires the specialized features of a mature hemocyte. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18813,35169,'lymph gland plasmatocyte differentiation','P','The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of the phagocytic blood-cell type, the plasmatocyte.','2013-10-27','NSRP'),(18814,35170,'lymph gland crystal cell differentiation','P','The process in which a relatively unspecialized larval lymph gland-derived hemocyte precursor cell acquires the specialized features of a crystal cell. Crystal cells are a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph.','2013-10-27','NSRP'),(18815,35171,'lamellocyte differentiation','P','The process in which a relatively unspecialized hemocyte precursor cell acquires the specialized features of a lamellocyte. Lamellocytes are a hemocyte lineage that exists only in larvae, but are seldom observed in healthy animals. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.','2013-10-27','NSRP'),(18816,35172,'hemocyte proliferation','P','The multiplication or reproduction of hemocytes, resulting in the expansion of the cell population. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen.','2013-10-27','NSRP'),(18817,35173,'histone kinase activity','F','Catalysis of the transfer of a phosphate group to a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.','2013-10-27','NSRP'),(18818,35174,'histone serine kinase activity','F','Catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.','2013-10-27','NSRP'),(18819,35175,'histone kinase activity (H3-S10 specific)','F','Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3.','2013-10-27','NSRP'),(18820,35176,'social behavior','P','Behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.','2013-10-27','NSRP'),(18821,35177,'larval foraging behavior','P','The movement of a larva through a feeding substrate whilst feeding on food.','2013-10-27','NSRP'),(18822,35178,'turning behavior','P','Fine-tuning the spatial position of an organism in response to variability in their environment. For example, reorientation of an organism in the direction of a food source.','2013-10-27','NSRP'),(18823,35179,'larval turning behavior','P','Fine-tuning the spatial position of a larva in response to variability in their environment. For example, reorientation of a larva in the direction of a food source.','2013-10-27','NSRP'),(18824,35180,'larval wandering behavior','P','The movement of a third instar larva through a substrate in search of a pupation site. This movement occurs without feeding and is characterized by short bursts of forward movement, separated by stops and repeated side-to-side head probes, followed normally by a change in direction.','2013-10-27','NSRP'),(18825,35181,'larval burrowing behavior','P','Digging into the substrate by non-feeding larvae in search for food-free sites suitable for pupation.','2013-10-27','NSRP'),(18826,35182,'female germline ring canal outer rim','C','An electron opaque backbone of the insect ovarian ring canal that is a part of or adjacent to the plasma membrane. The outer rim is established as the cleavage furrow is arrested, and contains F-actin, anillin, glycoproteins and at least one a protein with a high content of phosphorylated tyrosine residues.','2013-10-27','NSRP'),(18827,35183,'female germline ring canal inner rim','C','A proteinaceous actin-rich layer of the insect ovarian ring canal that forms subcortically to the outer rim. The electron dense inner rim accumulates after the final mitotic division of each germline syncytia, and contains actin, a phosphotyrosine protein, and a number of cytoskeletal proteins.','2013-10-27','NSRP'),(18828,35184,'histone threonine kinase activity','F','Catalysis of the transfer of a phosphate group to a threonine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.','2013-10-27','NSRP'),(18829,35185,'preblastoderm mitotic cell cycle','P','The first nine mitotic division cycles of the insect embryo, during which the dividing nuclei lie deep in the interior of the egg and divide nearly synchronously. This is the first phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis.','2013-10-27','NSRP'),(18830,35186,'syncytial blastoderm mitotic cell cycle','P','Mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively.','2013-10-27','NSRP'),(18831,35187,'hatching behavior','P','The specific behavior of an organism during the emergence from an egg shell. In Drosophila for example, the larva swings its head reiteratively through a semicircular arc, using its mouth hooks to tear apart the chorion in front of it and thus free itself from within the egg shell.','2013-10-27','NSRP'),(18832,35188,'hatching','P','The emergence of an immature organism from a protective structure.','2013-10-27','NSRP'),(18833,35189,'Rb-E2F complex','C','A multiprotein complex containing a heterodimeric E2F transcription factor and a Retinoblastoma (Rb) family member. This complex is capable of repressing transcription of E2F-regulated genes in order to regulate cell cycle progression.','2013-10-27','NSRP'),(18834,35190,'syncytial nuclear migration','P','The directed movement of nuclei within the syncytial embryo of insects. These precise temporal and spatial patterns of nuclear movement are coordinated with mitotic divisons and are required during blastoderm formation to reposition dividing nuclei from the interior of the syncytial embryo to the cortex.','2013-10-27','NSRP'),(18835,35191,'nuclear axial expansion','P','The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex.','2013-10-27','NSRP'),(18836,35192,'nuclear cortical migration','P','The symmetric outward movement of the syncytial nuclei from their positions in the ellipsoid toward the periphery of the embryo, during mitotic cycles 8 and 9. This movement results in the placement of nuclei in a uniform monolayer at the cortex of the developing embryo.','2013-10-27','NSRP'),(18837,35193,'larval central nervous system remodeling','P','Reorganization of the pre-existing, functional larval central nervous system into one that can serve the novel behavioral needs of the adult. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18838,35194,'posttranscriptional gene silencing by RNA','P','Any process of posttranscriptional gene inactivation (silencing) mediated by small RNA molecules that may trigger mRNA degradation or negatively regulate translation.','2013-10-27','NSRP'),(18839,35195,'gene silencing by miRNA','P','Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression.','2013-10-27','NSRP'),(18840,35196,'production of miRNAs involved in gene silencing by miRNA','P','Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein.','2013-10-27','NSRP'),(18841,35197,'siRNA binding','F','Interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme.','2013-10-27','NSRP'),(18842,35198,'miRNA binding','F','Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.','2013-10-27','NSRP'),(18843,35199,'salt aversion','P','The specific avoidance actions or reactions of an organism in response to the perception of salt.','2013-10-27','NSRP'),(18844,35200,'leg disc anterior/posterior pattern formation','P','The establishment, maintenance and elaboration of the anterior/posterior axis of the leg imaginal disc.','2013-10-27','NSRP'),(18845,35201,'leg disc anterior/posterior lineage restriction','P','Formation and/or maintenance of a lineage boundary between anterior and posterior compartments of the leg disc that cells cannot cross, thus separating the populations of cells in each compartment.','2013-10-27','NSRP'),(18846,35202,'tracheal pit formation in open tracheal system','P','Formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18847,35203,'regulation of lamellocyte differentiation','P','Any process that modulates the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.','2013-10-27','NSRP'),(18848,35204,'negative regulation of lamellocyte differentiation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.','2013-10-27','NSRP'),(18849,35205,'positive regulation of lamellocyte differentiation','P','Any process that activates or increases the frequency, rate or extent of lamellocyte differentiation. Lamellocytes differentiate massively in the lymph glands after parasitization and are large flat cells devoted to encapsulation of invaders too large to be phagocytosed by plasmatocytes.','2013-10-27','NSRP'),(18850,35206,'regulation of hemocyte proliferation','P','Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18851,35207,'negative regulation of hemocyte proliferation','P','Any process that stops, prevents or reduces the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18852,35208,'positive regulation of hemocyte proliferation','P','Any process that activates or increases the rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) that are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18853,35209,'pupal development','P','The process whose specific outcome is the progression of the pupa over time, from its formation to the mature structure. The pupa is a dormant life stage interposed between the larval and the adult stages in insects that undergo a complete metamorphosis.','2013-10-27','NSRP'),(18854,35210,'prepupal development','P','The process whose specific outcome is the progression of the prepupa over time, from its formation to the mature structure. The prepupal stage is a life stage interposed between the larval and the pupal stages in insects that undergo a complete metamorphosis. The start of the pre-pupal stage is marked by pupariation, and the end is marked by pupation.','2013-10-27','NSRP'),(18855,35211,'spermathecum morphogenesis','P','The process in which the anatomical structures of a spermathecum, a sperm storage organ, are generated and organized. Paired spermathecae lie at the anterior end of the insect uterus on the dorsal side. Each spermatheca consists of an oval shaped capsule, connected to the uterus by a spermathecal stalk.','2013-10-27','NSRP'),(18856,35212,'cell competition in a multicellular organism','P','Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells.','2013-10-27','NSRP'),(18857,35213,'clypeo-labral disc development','P','The process whose specific outcome is the progression of the clypeo-labral disc over time, from its formation to the metamorphosis to form adult structures. The clypeo-labral disc develops into the labrum, anterior cibarial plate, fish trap bristles, epistomal sclerite.','2013-10-27','NSRP'),(18858,35214,'eye-antennal disc development','P','Progression of the eye-antennal imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the eye, antenna, head capsule and maxillary palps.','2013-10-27','NSRP'),(18859,35215,'genital disc development','P','Progression of the genital imaginal disc over time, from its initial formation through to its metamorphosis to form the adult terminalia, comprising the entire set of internal and external genitalia and analia. Both sexes of Drosophila have a single genital disc formed from the female and male genital primordia, and the anal primordium. The anal primordium develops in both sexes, forming either male or female analia. However, only one of the genital primordia develops in each sex, forming either the male or the female genitalia.','2013-10-27','NSRP'),(18860,35216,'haltere disc development','P','Progression of the haltere imaginal disc over time, from its initial formation through to its metamorphosis to form the adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum.','2013-10-27','NSRP'),(18861,35217,'labial disc development','P','Progression of the labial imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including parts of the proboscis.','2013-10-27','NSRP'),(18862,35218,'leg disc development','P','Progression of the leg imaginal disc over time, from its initial formation through to its metamorphosis to form adult structures including the leg, coxa and ventral thoracic pleura.','2013-10-27','NSRP'),(18863,35219,'prothoracic disc development','P','Progression of the prothoracic disc over time, from its initial formation through to its metamorphosis to form the adult humerous and anterior spiracle.','2013-10-27','NSRP'),(18864,35220,'wing disc development','P','Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.','2013-10-27','NSRP'),(18865,35221,'genital disc pattern formation','P','The process that gives rise to the patterns of cell differentiation that will arise in the genital imaginal disc.','2013-10-27','NSRP'),(18866,35222,'wing disc pattern formation','P','The process giving rise to the pattern of cell differentiation in the wing imaginal disc.','2013-10-27','NSRP'),(18867,35223,'leg disc pattern formation','P','The process that gives rise to the patterns of cell differentiation in the leg imaginal disc.','2013-10-27','NSRP'),(18868,35224,'genital disc anterior/posterior pattern formation','P','The establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium).','2013-10-27','NSRP'),(18869,35225,'determination of genital disc primordium','P','Allocation of embryonic cells to the genital imaginal disc founder populations. Early in development at the blastoderm stage, the anlage of the genital disc of both sexes consists of three primordia: the female genital primoridum lcoated anteriorly, the anal primoridum located posteriorly, and the male gential primordium between the two.','2013-10-27','NSRP'),(18870,35226,'glutamate-cysteine ligase catalytic subunit binding','F','Interacting selectively and non-covalently with the catalytic subunit of glutamate-cysteine ligase.','2013-10-27','NSRP'),(18871,35227,'regulation of glutamate-cysteine ligase activity','P','Any process that modulates the activity of glutamate-cysteine ligase.','2013-10-27','NSRP'),(18872,35228,'negative regulation of glutamate-cysteine ligase activity','P','Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase.','2013-10-27','NSRP'),(18873,35229,'positive regulation of glutamate-cysteine ligase activity','P','Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.','2013-10-27','NSRP'),(18874,35230,'cytoneme','C','A long, thin, polarized cell projection that contains actin and can extend for distances many times the diameter of the cell. Cytonemes represent extensions of cell cytoplasm and typically have a diameter of approximately 0.2um.','2013-10-27','NSRP'),(18875,35231,'cytoneme assembly','P','Formation of a cytoneme, a long, thin and polarized actin-based cytoplasmic extension that projects from a cell.','2013-10-27','NSRP'),(18876,35232,'germ cell attraction','P','The directed movement of a germ cell from their site of production to the gonad, through the attraction of cells towards their target.','2013-10-27','NSRP'),(18877,35233,'germ cell repulsion','P','The directed movement of a germ cell from their site of production to the gonad, through the repulsion of cells away from a tissue.','2013-10-27','NSRP'),(18878,35234,'germ cell programmed cell death','P','Programmed cell death of an errant germ line cell that is outside the normal migratory path or ectopic to the gonad. This is an important mechanism of regulating germ cell survival within the embryo.','2013-10-27','NSRP'),(18879,35235,'ionotropic glutamate receptor signaling pathway','P','A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(18880,35236,'proctolin receptor activity','F','Combining with the neuropeptide proctolin, to initiate a change in cell activity.','2013-10-27','NSRP'),(18881,35237,'corazonin receptor activity','F','Combining with the neuropeptide corazonin to initiate a change in cell activity.','2013-10-27','NSRP'),(18882,35238,'vitamin A biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid. Animals cannot synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids.','2013-10-27','NSRP'),(18883,35239,'tube morphogenesis','P','The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.','2013-10-27','NSRP'),(18884,35240,'dopamine binding','F','Interacting selectively and non-covalently with dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine.','2013-10-27','NSRP'),(18885,35241,'protein-arginine omega-N monomethyltransferase activity','F','Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue.','2013-10-27','NSRP'),(18886,35242,'protein-arginine omega-N asymmetric methyltransferase activity','F','Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues.','2013-10-27','NSRP'),(18887,35243,'protein-arginine omega-N symmetric methyltransferase activity','F','Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the terminal nitrogen (omega nitrogen) residue that is not already methylated, resulting in symmetrical peptidyl-N(omega),N\'(omega)-dimethyled arginine residues.','2013-10-27','NSRP'),(18888,35244,'peptidyl-arginine C-methyltransferase activity','F','Catalysis of the transfer of a methyl group to the carbon atom of an arginine residue in a protein.','2013-10-27','NSRP'),(18889,35245,'peptidyl-arginine C-methylation','P','The addition of a methyl group onto a carbon atom of an arginine residue in a protein.','2013-10-27','NSRP'),(18890,35246,'peptidyl-arginine N-methylation','P','The addition of a methyl group onto a nitrogen atom of an arginine residue in a protein.','2013-10-27','NSRP'),(18891,35247,'peptidyl-arginine omega-N-methylation','P','The addition of a methyl group onto a terminal nitrogen (omega nitrogen) atom of an arginine residue in a protein.','2013-10-27','NSRP'),(18892,35248,'alpha-1,4-N-acetylgalactosaminyltransferase activity','F','Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming an alpha-1,4 linkage.','2013-10-27','NSRP'),(18893,35249,'synaptic transmission, glutamatergic','P','The process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.','2013-10-27','NSRP'),(18894,35250,'UDP-galactosyltransferase activity','F','Catalysis of the transfer of a galactose group from UDP-galactose to an acceptor molecule.','2013-10-27','NSRP'),(18895,35251,'UDP-glucosyltransferase activity','F','Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule.','2013-10-27','NSRP'),(18896,35252,'UDP-xylosyltransferase activity','F','Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule.','2013-10-27','NSRP'),(18897,35253,'ciliary rootlet','C','A cytoskeleton-like structure, originating from the basal body at the proximal end of a cilium, and extending proximally toward the cell nucleus. Rootlets are typically 80-100 nm in diameter and contain cross striae distributed at regular intervals of approximately 55-70 nm.','2013-10-27','NSRP'),(18898,35254,'glutamate receptor binding','F','Interacting selectively and non-covalently with a glutamate receptor.','2013-10-27','NSRP'),(18899,35255,'ionotropic glutamate receptor binding','F','Interacting selectively and non-covalently with an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels.','2013-10-27','NSRP'),(18900,35256,'G-protein coupled glutamate receptor binding','F','Interacting selectively and non-covalently with a G-protein coupled glutamate receptor (a metabotropic glutamate receptor).','2013-10-27','NSRP'),(18901,35257,'nuclear hormone receptor binding','F','Interacting selectively and non-covalently with a nuclear hormone receptor, a ligand-dependent receptor found in the nucleus of the cell.','2013-10-27','NSRP'),(18902,35258,'steroid hormone receptor binding','F','Interacting selectively and non-covalently with a steroid hormone receptor.','2013-10-27','NSRP'),(18903,35259,'glucocorticoid receptor binding','F','Interacting selectively and non-covalently with a glucocorticoid receptor.','2013-10-27','NSRP'),(18904,35260,'internal genitalia morphogenesis','P','The process in which the anatomical structures of the internal genitalia are generated and organized. The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals.','2013-10-27','NSRP'),(18905,35261,'external genitalia morphogenesis','P','The process in which the anatomical structures of the external genitalia are generated and organized. The external genitalia are the outer sex organs, such as the penis or vulva in mammals.','2013-10-27','NSRP'),(18906,35262,'gonad morphogenesis','P','The process in which the anatomical structures of the gonads are generated and organized. A gonad is an animal organ producing gametes, e.g. the testes or the ovary in mammals.','2013-10-27','NSRP'),(18907,35263,'genital disc sexually dimorphic development','P','The sex-specific patterns of primoridia growth and differentiation in the genital imaginal disc. The anal primordium of the genital disc develops in both sexes, but depending on the genetic sex gives rise to either male or female analia. Depending on the genetic sex, only one of the two genital primordia develop. In females the female genital primordium develops and gives rise to the female genitalia whereas the male primordium is repressed. Conversely, in males the male genital primordium develops and gives rise to the male genitalia whereas the female genital primordium is repressed.','2013-10-27','NSRP'),(18908,35264,'multicellular organism growth','P','The increase in size or mass of an entire multicellular organism, as opposed to cell growth.','2013-10-27','NSRP'),(18909,35265,'organ growth','P','The increase in size or mass of an organ. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that function together as to perform a specific function.','2013-10-27','NSRP'),(18910,35266,'meristem growth','P','The increase in size or mass of a meristem, a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation.','2013-10-27','NSRP'),(18911,35267,'NuA4 histone acetyltransferase complex','C','A complex having histone acetylase activity on chromatin, as well as ATPase, DNA helicase and structural DNA binding activities. The complex is thought to be involved in double-strand DNA break repair. Subunits of the human complex include HTATIP/TIP60, TRRAP, RUVBL1, BUVBL2, beta-actin and BAF53/ACTL6A. In yeast, the complex has 13 subunits, including the catalytic subunit Esa1 (homologous to human Tip60).','2013-10-27','NSRP'),(18912,35268,'protein mannosylation','P','The addition of a mannose residue to a protein acceptor molecule.','2013-10-27','NSRP'),(18913,35269,'protein O-linked mannosylation','P','The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.','2013-10-27','NSRP'),(18914,35270,'endocrine system development','P','Progression of the endocrine system over time, from its formation to a mature structure. The endocrine system is a system of hormones and ductless glands, where the glands release hormones directly into the blood, lymph or other intercellular fluid, and the hormones circulate within the body to affect distant organs. The major glands that make up the human endocrine system are the hypothalamus, pituitary, thyroid, parathryoids, adrenals, pineal body, and the reproductive glands which include the ovaries and testes.','2013-10-27','NSRP'),(18915,35271,'ring gland development','P','Progression of the ring gland over time, from its formation to a mature structure. The ring gland is a neuroendocrine organ found in higher Dipterans, which is composed of the prothoracic gland, the corpus allatum, and the corpora cardiacum. The ring gland is the site of production and release of ecdysteroids and juvenile hormones.','2013-10-27','NSRP'),(18916,35272,'exocrine system development','P','Progression of the exocrine system over time, from its formation to a mature structure. The exocrine system is a system of hormones and glands, where the glands secrete straight to a target site via ducts or tubes. The human exocrine system includes the salivary glands, sweat glands and many glands of the digestive system.','2013-10-27','NSRP'),(18917,35273,'phthalate binding','F','Interacting selectively and non-covalently with a phthalate, any ester or salt of phthalic acid.','2013-10-27','NSRP'),(18918,35274,'diphenyl phthalate binding','F','Interacting selectively and non-covalently with diphenyl phthalate, C(20)H(14)O(4).','2013-10-27','NSRP'),(18919,35275,'dibutyl phthalate binding','F','Interacting selectively and non-covalently with dibutyl phthalate, C(16)H(22)O(4).','2013-10-27','NSRP'),(18920,35276,'ethanol binding','F','Interacting selectively and non-covalently with ethanol, CH(3)-CH(2)-OH.','2013-10-27','NSRP'),(18921,35277,'spiracle morphogenesis, open tracheal system','P','The process in which the anatomical structures of a spiracle are generated and organized. Spiracles are the openings in the insect open tracheal system; externally they connect to the epidermis and internally they connect to the tracheal trunk.','2013-10-27','NSRP'),(18922,35278,'negative regulation of translation involved in gene silencing by miRNA','P','The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically repress translation if the miRNA imperfectly base-pairs with the 3\' untranslated regions of target mRNAs.','2013-10-27','NSRP'),(18923,35279,'mRNA cleavage involved in gene silencing by miRNA','P','The process in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically direct cleavage by base pairing with near-perfect complementarity to the target mRNA. Many plant miRNAs downregulate gene expression through this mechanism.','2013-10-27','NSRP'),(18924,35280,'miRNA loading onto RISC involved in gene silencing by miRNA','P','The transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC).','2013-10-27','NSRP'),(18925,35281,'pre-miRNA export from nucleus','P','Transport of pre-microRNAs (pre-miRNAs) from the nucleus to the cytoplasm. Pre-miRNAs are a ~60-70 nucleotide stem loop intermediate in miRNA production, produced by the nuclear cleavage of a primary miRNA (pri-mRNA) transcript. Pre-miRNAs are transported from the nucleus to the cytoplasm where further cleavage occurs to produce a mature miRNA product.','2013-10-27','NSRP'),(18926,35282,'segmentation','P','The regionalization process that divides an organism or part of an organism into a series of semi-repetitive parts, or segments, often arranged along a longitudinal axis.','2013-10-27','NSRP'),(18927,35283,'central nervous system segmentation','P','Division of the central nervous system into a series of semi-repetitive parts or segments.','2013-10-27','NSRP'),(18928,35284,'brain segmentation','P','Division of the brain into a series of semi-repetitive parts or segments.','2013-10-27','NSRP'),(18929,35285,'appendage segmentation','P','Division of an appendage, an organ or part that is attached to the main body of an organism, into a series of semi-repetitive parts or segments. Most arthropod appendages, such as the legs and antennae, are visibly segmented.','2013-10-27','NSRP'),(18930,35286,'leg segmentation','P','OBSOLETE. Division of a leg into a series of semi-repetitive parts or segments. Most arthropod appendages are visibly segmented; the Drosophila leg for example has nine segments, each separated from the next by a flexible joint.','2013-10-27','NSRP'),(18931,35287,'head segmentation','P','Partitioning the insect head anlage into a fixed number of segmental units. The number of segments composing the insect head has long been a subject of debate, but it is generally agreed that there are 6 or 7 segments. From anterior to posterior the head segments are the procephalic segments (labral, (ocular), antennal and intercalary) and the gnathal segments (mandibular, maxillary and labial).','2013-10-27','NSRP'),(18932,35288,'anterior head segmentation','P','Partitioning the insect head anlage into procephalic (labral, (ocular), antennal and intercalary) segments. The procephalic segments lie anterior to the gnathal (posterior head) segments, and are pattered by different segmentation gene cascades to the abdominal, thoracic and posterior head (gnathal) segments.','2013-10-27','NSRP'),(18933,35289,'posterior head segmentation','P','Partitioning the posterior region of the insect head anlage into gnathal (mandibular, maxillary and labial) segments. Unlike the anterior head (procephalic) segments, formation of the posterior head (gnathal) segments occurs by a similar mechanism to trunk segmentation, where a cascade of gap genes, pair-rule genes and segment-polarity genes subdivide the embryo into progressively smaller domains.','2013-10-27','NSRP'),(18934,35290,'trunk segmentation','P','Partitioning of the blastoderm embryo into trunk segmental units. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8.','2013-10-27','NSRP'),(18935,35291,'specification of segmental identity, intercalary segment','P','The specification of the characteristic structures of the intercalary segment of the anterior head, following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.','2013-10-27','NSRP'),(18936,35292,'specification of segmental identity, trunk','P','The specification of the characteristic structures of trunk segments, following establishment of segment boundaries. In Drosophila, the trunk segments include thoracic segments and abdominal segments A1 to A8. Identity is considered to be the aggregate of characteristics by which a structure is recognized.','2013-10-27','NSRP'),(18937,35293,'chitin-based larval cuticle pattern formation','P','The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18938,35294,'determination of wing disc primordium','P','Allocation of embryonic cells to the wing disc founder populations, groups of cells that are committed to contribute to the formation of a wing imaginal disc.','2013-10-27','NSRP'),(18939,35295,'tube development','P','The process whose specific outcome is the progression of a tube over time, from its initial formation to a mature structure. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues including lung and trachea, kidney, the mammary gland, the vascular system and the gastrointestinal and urinary-genital tracts.','2013-10-27','NSRP'),(18940,35296,'regulation of tube diameter','P','Ensuring that a tube is the correct width.','2013-10-27','NSRP'),(18941,35297,'regulation of Malpighian tubule diameter','P','Ensuring that the Malpighian tubule is the correct width. Malpighian tubules have a uniform circumference along their length; the circumference of the tubes is eight cells during the time the cells are dividing, after which the cells rearrange producting tubes with a cirumference of two cells.','2013-10-27','NSRP'),(18942,35298,'regulation of Malpighian tubule size','P','Ensuring that a Malpighian tubule is the correct length and diameter.','2013-10-27','NSRP'),(18943,35299,'inositol pentakisphosphate 2-kinase activity','F','Catalysis of the reaction: 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + 2 H(+).','2013-10-27','NSRP'),(18944,35300,'inositol-1,3,4-trisphosphate 5/6-kinase activity','F','OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate, and ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.','2013-10-27','NSRP'),(18945,35301,'Hedgehog signaling complex','C','A multiprotein complex that binds microtubules in a Hedgehog-dependent manner, and is required for signal transduction by members of the Hedgehog family of proteins. The core components of the complex are the serine/threonine protein kinase Fused, the kinesin motor protein Costal2 (Cos2), and a zinc finger transcription factor (Gli family members in humans, and Cubitus interruptus (Ci) in Drosophila).','2013-10-27','NSRP'),(18946,35302,'ecdysteroid 25-hydroxylase activity','F','Catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods.','2013-10-27','NSRP'),(18947,35303,'regulation of dephosphorylation','P','Any process that modulates the frequency, rate or extent of removal of phosphate groups from a molecule.','2013-10-27','NSRP'),(18948,35304,'regulation of protein dephosphorylation','P','Any process that modulates the frequency, rate or extent of removal of phosphate groups from a protein.','2013-10-27','NSRP'),(18949,35305,'negative regulation of dephosphorylation','P','Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a molecule.','2013-10-27','NSRP'),(18950,35306,'positive regulation of dephosphorylation','P','Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a molecule.','2013-10-27','NSRP'),(18951,35307,'positive regulation of protein dephosphorylation','P','Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.','2013-10-27','NSRP'),(18952,35308,'negative regulation of protein dephosphorylation','P','Any process the stops, prevents, or reduces the frequency, rate or extent of removal of phosphate groups from a protein.','2013-10-27','NSRP'),(18953,35309,'wing and notum subfield formation','P','The regionalization process that subdivides the wing imaginal disc into the wing and notum (body wall) subfields, thus determining whether cells ultimately differentiate wing or notum-specific structures.','2013-10-27','NSRP'),(18954,35310,'notum cell fate specification','P','The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment.','2013-10-27','NSRP'),(18955,35311,'wing cell fate specification','P','The process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a wing cell, if left in its normal environment.','2013-10-27','NSRP'),(18956,35312,'5\'-3\' exodeoxyribonuclease activity','F','Catalysis of the sequential cleavage of mononucleotides from a free 5\' terminus of a DNA molecule.','2013-10-27','NSRP'),(18957,35313,'wound healing, spreading of epidermal cells','P','The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.','2013-10-27','NSRP'),(18958,35314,'scab formation','P','Formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection.','2013-10-27','NSRP'),(18959,35315,'hair cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a hair cell.','2013-10-27','NSRP'),(18960,35316,'non-sensory hair organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of non-sensory hairs. These hairs are polarized cellular extensions that cover much of the insect epidermis.','2013-10-27','NSRP'),(18961,35317,'imaginal disc-derived wing hair organization','P','A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(18962,35318,'imaginal disc-derived wing hair outgrowth','P','Extrusion of a cellular projection from the apical membrane of an epithelial cell in an imaginal disc-derived wing. Outgrowth initiates approximately 35 hours after puparium formation from the distal side of the cell, and at this stage the cellular extension is termed a prehair.','2013-10-27','NSRP'),(18963,35319,'imaginal disc-derived wing hair elongation','P','Growth of a prehair in the approximately 10 hour period following its emergence from an epidermal cell in an imaginal disc-derived wing. Prehair elongation is guided and/or driven by the polymerization of actin filaments and the orderly crosslinking of filaments into bundles.','2013-10-27','NSRP'),(18964,35320,'imaginal disc-derived wing hair site selection','P','Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally.','2013-10-27','NSRP'),(18965,35321,'maintenance of imaginal disc-derived wing hair orientation','P','Ensuring that hairs in the imaginal disc-derived wing continue to point distally during development, following the initial establishment of wing hair polarity.','2013-10-27','NSRP'),(18966,35322,'mesenchymal cell migration involved in limb bud formation','P','The orderly movement of a mesenchymal cell from one site to another that will contribute to the formation of a limb bud.','2013-10-27','NSRP'),(18967,35323,'male germline ring canal','C','An intercellular bridge that connects the germline cells of a male cyst.','2013-10-27','NSRP'),(18968,35324,'female germline ring canal','C','An intercellular bridge that connects the germline cells of a female cyst.','2013-10-27','NSRP'),(18969,35325,'Toll-like receptor binding','F','Interacting selectively and non-covalently with a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response.','2013-10-27','NSRP'),(18970,35326,'enhancer binding','F','Interacting selectively and non-covalently with an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter.','2013-10-27','NSRP'),(18971,35327,'transcriptionally active chromatin','C','The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.','2013-10-27','NSRP'),(18972,35328,'transcriptionally silent chromatin','C','The ordered and organized complex of DNA and protein that forms regions of the chromosome that are not being actively transcribed.','2013-10-27','NSRP'),(18973,35329,'hippo signaling cascade','P','The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.','2013-10-27','NSRP'),(18974,35330,'regulation of hippo signaling cascade','P','Any process that modulates the frequency, rate or extent of hippo signaling.','2013-10-27','NSRP'),(18975,35331,'negative regulation of hippo signaling cascade','P','Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.','2013-10-27','NSRP'),(18976,35332,'positive regulation of hippo signaling cascade','P','Any process that activates or increases the frequency, rate or extent of hippo signaling.','2013-10-27','NSRP'),(18977,35333,'Notch receptor processing, ligand-dependent','P','The proteolytic cleavages to the Notch protein that occur as a result of ligand binding. Ligand binding at the cell surface exposes an otherwise inaccessible cleavage site in the extracellular portion of Notch, which when cleaved releases a membrane-tethered form of the Notch intracellular domain. Subsequent cleavage within the transmembrane domain then leads to the release of the soluble Notch intracellular domain (NICD).','2013-10-27','NSRP'),(18978,35334,'Notch receptor processing, ligand-independent','P','The proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.','2013-10-27','NSRP'),(18979,35335,'peptidyl-tyrosine dephosphorylation','P','The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.','2013-10-27','NSRP'),(18980,35336,'long-chain fatty-acyl-CoA metabolic process','P','The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.','2013-10-27','NSRP'),(18981,35337,'fatty-acyl-CoA metabolic process','P','The chemical reactions and pathways involving a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.','2013-10-27','NSRP'),(18982,35338,'long-chain fatty-acyl-CoA biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.','2013-10-27','NSRP'),(18983,35339,'SPOTS complex','C','A multiprotein complex at least composed of serine palmitoyltransferases and ORM proteins (known as ORMDL proteins in mammals and other higher vertebrates) that plays a key role in sphingolipid homeostasis.','2013-10-27','NSRP'),(18984,35340,'inosine transport','P','The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(18985,35341,'regulation of inosine transport','P','Any process that modulates the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(18986,35342,'positive regulation of inosine transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(18987,35343,'negative regulation of inosine transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of inosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(18988,35344,'hypoxanthine transport','P','The directed movement of hypoxanthine, 6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(18989,35345,'regulation of hypoxanthine transport','P','Any process that modulates the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(18990,35346,'positive regulation of hypoxanthine transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(18991,35347,'negative regulation of hypoxanthine transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of hypoxanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(18992,35348,'acetyl-CoA transmembrane transport','P','The process in which acetyl-CoA is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis.','2013-10-27','NSRP'),(18993,35349,'coenzyme A transmembrane transport','P','The process in which coenzyme A is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Coenzyme A, 3\'-phosphoadenosine-(5\')diphospho(4\')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.','2013-10-27','NSRP'),(18994,35350,'FAD transmembrane transport','P','The process in which flavin-adenine dinucleotide (FAD) is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form.','2013-10-27','NSRP'),(18995,35351,'heme transmembrane transport','P','The process in which heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(18996,35352,'NAD transmembrane transport','P','The process in which nicotinamide adenine dinucleotide is transported from one side of a membrane to the other by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH.','2013-10-27','NSRP'),(18997,35353,'nicotinamide mononucleotide transmembrane transport','P','The process in which nicotinamide mononucleotide is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP.','2013-10-27','NSRP'),(18998,35354,'Toll-like receptor 1-Toll-like receptor 2 protein complex','C','A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2).','2013-10-27','NSRP'),(18999,35355,'Toll-like receptor 2-Toll-like receptor 6 protein complex','C','A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6).','2013-10-27','NSRP'),(19000,35356,'cellular triglyceride homeostasis','P','Any process involved in the maintenance of an internal steady state of triglyceride within a cell or between a cell and its external environment.','2013-10-27','NSRP'),(19001,35357,'peroxisome proliferator activated receptor signaling pathway','P','The series of molecular signals initiated by binding of a ligand to any of the peroxisome proliferator activated receptors (alpha, beta or gamma) in the nuclear membrane, and ending with the initiation or termination of the transcription of target genes.','2013-10-27','NSRP'),(19002,35358,'regulation of peroxisome proliferator activated receptor signaling pathway','P','Any process that modulates the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.','2013-10-27','NSRP'),(19003,35359,'negative regulation of peroxisome proliferator activated receptor signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.','2013-10-27','NSRP'),(19004,35360,'positive regulation of peroxisome proliferator activated receptor signaling pathway','P','Any process that activates or increases the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway.','2013-10-27','NSRP'),(19005,35361,'Cul8-RING ubiquitin ligase complex','C','A ubiquitin ligase complex in which a cullin from the Cul8 subfamily and a RING domain protein form the catalytic core. In S. cerevisiae, Mms1p acts as the adaptor protein and substrate specificity is conferred by any of a number of different proteins.','2013-10-27','NSRP'),(19006,35362,'protein-DNA ISRE complex assembly','P','The aggregation, arrangement and bonding together of proteins and DNA molecules to form a protein-DNA complex, in which the complex is formed through interaction of the protein(s) with a interferon-stimulated response element (ISRE) in the DNA.','2013-10-27','NSRP'),(19007,35363,'histone locus body','C','A nuclear body associated with the histone gene locus that is thought to contain all of the factors necessary for histone mRNA transcription and pre-mRNA processing. In Drosophila, U7 snRNP is located in the histone locus body rather than the distinct Cajal body.','2013-10-27','NSRP'),(19008,35364,'thymine transport','P','The directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19009,35365,'regulation of thymine transport','P','Any process that modulates the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19010,35366,'negative regulation of thymine transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19011,35367,'positive regulation of thymine transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of thymine, 5-methyluracil, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19012,35368,'selenocysteine insertion sequence binding','F','Interacting selectively and non-covalently with the selenocysteine insertion sequence (SECIS), a regulatory sequence within mRNA which directs incorporation of a selenocysteine at a stop codon (UGA) during translation.','2013-10-27','NSRP'),(19013,35369,'pre-B cell receptor complex','C','An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins.','2013-10-27','NSRP'),(19014,35370,'UBC13-UEV1A complex','C','A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A).','2013-10-27','NSRP'),(19015,35371,'microtubule plus end','C','The growing (plus) end of a microtubule. In vitro, microtubules polymerize more quickly at the plus end than at the minus end. In vivo, microtubule growth occurs only at the plus end, and the plus end switches between periods of growth and shortening, a behavior known as dynamic instability.','2013-10-27','NSRP'),(19016,35372,'protein localization to microtubule','P','A process in which a protein is transported to, or maintained at, a microtubule.','2013-10-27','NSRP'),(19017,35373,'chondroitin sulfate proteoglycan binding','F','Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.','2013-10-27','NSRP'),(19018,35374,'chondroitin sulfate binding','F','Interacting selectively and non-covalently with chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc).','2013-10-27','NSRP'),(19019,35375,'zymogen binding','F','Interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis.','2013-10-27','NSRP'),(19020,35376,'sterol import','P','The directed movement of a sterol into a cell or organelle. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.','2013-10-27','NSRP'),(19021,35377,'transepithelial water transport','P','The directed movement of water (H2O) from one side of an epithelium to the other.','2013-10-27','NSRP'),(19022,35378,'carbon dioxide transmembrane transport','P','A process in which carbon dioxide (CO2) is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19023,35379,'carbon dioxide transmembrane transporter activity','F','Enables the transfer of carbon dioxide (CO2) from one side of a membrane to the other.','2013-10-27','NSRP'),(19024,35380,'very long-chain-3-hydroxyacyl-CoA dehydrogenase activity','F','Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.','2013-10-27','NSRP'),(19025,35381,'ATP-gated ion channel activity','F','Catalysis of the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts.','2013-10-27','NSRP'),(19026,35382,'sterol transmembrane transport','P','The directed movement of a sterol across a membrane into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.','2013-10-27','NSRP'),(19027,35383,'thioester metabolic process','P','The chemical reactions and pathways involving a thioester, a compound of general formula RC(=O)SR\' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol.','2013-10-27','NSRP'),(19028,35384,'thioester biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a thioester, a compound of general formula RC(=O)SR\' in which the linking oxygen in an ester is replaced by a sulfur atom. They are the product of esterification between a carboxylic acid and a thiol.','2013-10-27','NSRP'),(19029,35385,'Roundabout signaling pathway','P','A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19030,35386,'regulation of Roundabout signaling pathway','P','Any process that modulates the frequency, rate or extent of the Roundabout signaling pathway.','2013-10-27','NSRP'),(19031,35387,'negative regulation of Roundabout signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the Roundabout signaling pathway.','2013-10-27','NSRP'),(19032,35388,'positive regulation of Roundabout signaling pathway','P','Any process that activates or increases the frequency, rate or extent of the Roundabout signaling pathway.','2013-10-27','NSRP'),(19033,35389,'establishment of chromatin silencing at silent mating-type cassette','P','The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at silent mating-type loci.','2013-10-27','NSRP'),(19034,35390,'establishment of chromatin silencing at telomere','P','The initial formation of a transcriptionally silent chromatin structure such as heterochromatin at the telomere.','2013-10-27','NSRP'),(19035,35391,'maintenance of chromatin silencing at silent mating-type cassette','P','The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at silent mating-type loci.','2013-10-27','NSRP'),(19036,35392,'maintenance of chromatin silencing at telomere','P','The maintenance of chromatin in a transcriptionally silent state such as heterochromatin at the telomere.','2013-10-27','NSRP'),(19037,35393,'chemokine (C-X-C motif) ligand 9 production','P','The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(19038,35394,'regulation of chemokine (C-X-C motif) ligand 9 production','P','Any process that modulates the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9.','2013-10-27','NSRP'),(19039,35395,'negative regulation of chemokine (C-X-C motif) ligand 9 production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9.','2013-10-27','NSRP'),(19040,35396,'positive regulation of chemokine (C-X-C motif) ligand 9 production','P','Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-X-C motif) ligand 9.','2013-10-27','NSRP'),(19041,35397,'helper T cell enhancement of adaptive immune response','P','Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell.','2013-10-27','NSRP'),(19042,35398,'helper T cell enhancement of T cell mediated immune response','P','Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell.','2013-10-27','NSRP'),(19043,35399,'helper T cell enhancement of B cell mediated immune response','P','Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell.','2013-10-27','NSRP'),(19044,35400,'histone tyrosine kinase activity','F','Catalysis of the transfer of a phosphate group to a tyrosine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.','2013-10-27','NSRP'),(19045,35401,'histone kinase activity (H3-Y41 specific)','F','The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.','2013-10-27','NSRP'),(19046,35402,'histone kinase activity (H3-T11 specific)','F','Catalysis of the transfer of a phosphate group to the threonine-11 residue of the N-terminal tail of histone H3.','2013-10-27','NSRP'),(19047,35403,'histone kinase activity (H3-T6 specific)','F','Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3.','2013-10-27','NSRP'),(19048,35404,'histone-serine phosphorylation','P','The modification of histones by addition of a phosphate group to a serine residue.','2013-10-27','NSRP'),(19049,35405,'histone-threonine phosphorylation','P','The modification of histones by addition of a phosphate group to a threonine residue.','2013-10-27','NSRP'),(19050,35406,'histone-tyrosine phosphorylation','P','The modification of histones by addition of a phosphate group to a tyrosine residue.','2013-10-27','NSRP'),(19051,35407,'histone H3-T11 phosphorylation','P','The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone.','2013-10-27','NSRP'),(19052,35408,'histone H3-T6 phosphorylation','P','The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone.','2013-10-27','NSRP'),(19053,35409,'histone H3-Y41 phosphorylation','P','The modification of histone H3 by the addition of a phosphate group to a tyrosine residue at position 41 of the histone.','2013-10-27','NSRP'),(19054,35410,'dihydrotestosterone 17-beta-dehydrogenase activity','F','Catalysis of the reaction: 5alpha-dihydrotestosterone + NAD+ = 5alpha-androstane-3,17-dione + NADH.','2013-10-27','NSRP'),(19055,35411,'catenin import into nucleus','P','The directed movement of a catenin protein from the cytoplasm into the nucleus.','2013-10-27','NSRP'),(19056,35412,'regulation of catenin import into nucleus','P','Any process that modulates the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.','2013-10-27','NSRP'),(19057,35413,'positive regulation of catenin import into nucleus','P','Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.','2013-10-27','NSRP'),(19058,35414,'negative regulation of catenin import into nucleus','P','Any process that decreases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.','2013-10-27','NSRP'),(19059,35415,'regulation of mitotic prometaphase','P','OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region.','2013-10-27','NSRP'),(19060,35416,'positive regulation of mitotic prometaphase','P','OBSOLETE. Any process that activates or increases the frequency, rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region.','2013-10-27','NSRP'),(19061,35417,'negative regulation of mitotic prometaphase','P','OBSOLETE. Any process that stops, prevents or reduces the rate or extent of mitotic prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region.','2013-10-27','NSRP'),(19062,35418,'protein localization to synapse','P','Any process in which a protein is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.','2013-10-27','NSRP'),(19063,35419,'activation of MAPK activity involved in innate immune response','P','Any process that initiates the activity of the inactive enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.','2013-10-27','NSRP'),(19064,35420,'MAPK cascade involved in innate immune response','P','A MAPK cascade that contributes to an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.','2013-10-27','NSRP'),(19065,35421,'activation of MAPKK activity involved in innate immune response','P','Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.','2013-10-27','NSRP'),(19066,35422,'activation of MAPKKK activity involved in innate immune response','P','Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.','2013-10-27','NSRP'),(19067,35423,'inactivation of MAPK activity involved in innate immune response','P','Any process that terminates the activity of the active enzyme MAP kinase in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.','2013-10-27','NSRP'),(19068,35424,'MAPK import into nucleus involved in innate immune response','P','The directed movement of a MAP kinase to the nucleus in the context of an innate immune response, a defense response mediated by germline encoded components that directly recognize components of potential pathogens.','2013-10-27','NSRP'),(19069,35425,'autocrine signaling','P','Signaling between cells of the same type. The signal produced by the signaling cell binds to a receptor on, and affects a cell of the same type.','2013-10-27','NSRP'),(19070,35426,'extracellular matrix-cell signaling','P','Any process that mediates the transfer of information between the extracellular matrix and a cell.','2013-10-27','NSRP'),(19071,35427,'purine nucleoside transmembrane transport','P','The directed movement of a purine nucleoside across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2012-03-14','NSRP'),(19072,35428,'hexose transmembrane transport','P','The directed movement of hexose across a membrane by means of some agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule.','2013-10-27','NSRP'),(19073,35429,'gluconate transmembrane transport','P','The directed movement of gluconate across a membrane by means of some agent such as a transporter or pore. Gluconate is the aldonic acid derived from glucose.','2013-10-27','NSRP'),(19074,35430,'regulation of gluconate transmembrane transport','P','Any process that modulates the frequency, rate or extent of the directed movement of a gluconate across a membrane by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19075,35431,'negative regulation of gluconate transmembrane transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19076,35432,'positive regulation of gluconate transmembrane transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of gluconate across a membrane by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19077,35433,'acetate transmembrane transport','P','The directed movement of acetate across a membrane by means of some agent such as a transporter or pore. Acetate is the 2-carbon carboxylic acid ethanoic acid.','2013-10-27','NSRP'),(19078,35434,'copper ion transmembrane transport','P','The directed movement of copper cation across a membrane.','2013-10-27','NSRP'),(19079,35435,'phosphate ion transmembrane transport','P','The directed movement of phosphate across a membrane by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19080,35436,'triose phosphate transmembrane transport','P','The directed movement of triose phosphate across a membrane by means of some agent such as a transporter or pore. Triose phosphate is any organic three carbon compound phosphate ester.','2013-10-27','NSRP'),(19081,35437,'maintenance of protein localization in endoplasmic reticulum','P','Any process in which a protein is maintained in the endoplasmic reticulum and prevented from moving elsewhere. These include sequestration within the endoplasmic reticulum, protein stabilization to prevent transport elsewhere and the active retrieval of proteins that escape the endoplasmic reticulum.','2013-10-27','NSRP'),(19082,35438,'cyclic-di-GMP binding','F','Interacting selectively and non-covalently with cyclic-di-GMP, cyclic dimeric guanosine monophosphate.','2013-10-27','NSRP'),(19083,35439,'halimadienyl-diphosphate synthase activity','F','Catalysis of the reaction: geranylgeranyl diphosphate = halima-5(6),13-dien-15-yl diphosphate.','2013-10-27','NSRP'),(19084,35440,'tuberculosinol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of tuberculosinol (halima-5,6,dien-15-ol), a secondary metabolite in Mycobacteria.','2013-10-27','NSRP'),(19085,35441,'cell migration involved in vasculogenesis','P','The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.','2013-10-27','NSRP'),(19086,35442,'dipeptide transmembrane transport','P','The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.','2013-10-27','NSRP'),(19087,35443,'tripeptide transmembrane transport','P','The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds.','2013-10-27','NSRP'),(19088,35444,'nickel cation transmembrane transport','P','The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19089,35445,'borate transmembrane transport','P','The directed movement of borate across a membrane by means of some agent such as a transporter or pore. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals.','2013-10-27','NSRP'),(19090,35446,'cysteine-glucosaminylinositol ligase activity','F','Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins.','2013-10-27','NSRP'),(19091,35447,'mycothiol synthase activity','F','Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol.','2013-10-27','NSRP'),(19092,35448,'extrinsic to thylakoid membrane','C','Loosely bound to one surface of a thylakoid membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(19093,35449,'extrinsic to plastid thylakoid membrane','C','Loosely bound to one surface of a plastid thylakoid membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(19094,35450,'extrinsic to lumenal side of plastid thylakoid membrane','C','Loosely bound to the surface of a plastid thylakoid membrane that faces the lumen but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(19095,35451,'extrinsic to stromal side of plastid thylakoid membrane','C','Loosely bound to the surface of a plastid thylakoid membrane that faces the stroma but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(19096,35452,'extrinsic to plastid membrane','C','Loosely bound to one surface of a plastid membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(19097,35453,'extrinsic to plastid inner membrane','C','Loosely bound to one surface of a plastid inner membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(19098,35454,'extrinsic to stromal side of plastid inner membrane','C','Loosely bound to the surface of a plastid inner membrane that faces the stroma, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(19099,35455,'response to interferon-alpha','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.','2013-10-27','NSRP'),(19100,35456,'response to interferon-beta','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.','2013-10-27','NSRP'),(19101,35457,'cellular response to interferon-alpha','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.','2013-10-27','NSRP'),(19102,35458,'cellular response to interferon-beta','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.','2013-10-27','NSRP'),(19103,35459,'cargo loading into vesicle','P','The formation of a protein complex between the coat proteins and proteins that are going to be transported by a vesicle.','2013-10-27','NSRP'),(19104,35460,'L-ascorbate 6-phosphate lactonase activity','F','Catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate.','2013-10-27','NSRP'),(19105,35461,'vitamin transmembrane transport','P','The process in which a vitamin is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.','2013-10-27','NSRP'),(19106,35462,'determination of left/right asymmetry in diencephalon','P','The establishment of the diencephalon with respect to the left and right halves.','2013-10-27','NSRP'),(19107,35463,'transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry','P','A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves.','2013-10-27','NSRP'),(19108,35464,'regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry','P','Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of organismal asymmetry with regard to its left and right halves.','2013-10-27','NSRP'),(19109,35465,'regulation of transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry','P','OBSOLETE. Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of the lateral plate mesoderm with respect to its left and right halves.','2013-10-27','NSRP'),(19110,35469,'determination of pancreatic left/right asymmetry','P','Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism.','2013-10-27','NSRP'),(19111,35470,'positive regulation of vascular wound healing','P','Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.','2013-10-27','NSRP'),(19112,35471,'luteinizing hormone signaling pathway involved in ovarian follicle development','P','The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure.','2013-10-27','NSRP'),(19113,35472,'choriogonadotropin hormone receptor activity','F','Combining with the choriogonadotropin hormone to initiate a change in cell activity.','2013-10-27','NSRP'),(19114,35473,'lipase binding','F','Interacting selectively and non-covalently with any lipase.','2013-10-27','NSRP'),(19115,35474,'selective angioblast sprouting','P','The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel.','2013-10-27','NSRP'),(19116,35475,'angioblast cell migration involved in selective angioblast sprouting','P','The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations.','2013-10-27','NSRP'),(19117,35476,'angioblast cell migration','P','The orderly movement of angioblasts, cells involved in blood vessel morphogenesis.','2013-10-27','NSRP'),(19118,35477,'regulation of angioblast cell migration involved in selective angioblast sprouting','P','Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting.','2013-10-27','NSRP'),(19119,35478,'chylomicron binding','F','Interacting selectively and non-covalently with a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE.','2013-10-27','NSRP'),(19120,35479,'angioblast cell migration from lateral mesoderm to midline','P','The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature.','2013-10-27','NSRP'),(19121,35480,'regulation of Notch signaling pathway involved in heart induction','P','Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.','2013-10-27','NSRP'),(19122,35481,'positive regulation of Notch signaling pathway involved in heart induction','P','Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.','2013-10-27','NSRP'),(19123,35482,'gastric motility','P','The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum.','2013-10-27','NSRP'),(19124,35483,'gastric emptying','P','The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum.','2013-10-27','NSRP'),(19125,35484,'adenine/adenine mispair binding','F','Interacting selectively and non-covalently with double-stranded DNA containing an A/A mispair.','2013-10-27','NSRP'),(19126,35485,'adenine/guanine mispair binding','F','Interacting selectively and non-covalently with double-stranded DNA containing an A/G mispair.','2013-10-27','NSRP'),(19127,35486,'cytosine/cytosine mispair binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a C/C mispair.','2013-10-27','NSRP'),(19128,35487,'thymine/thymine mispair binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a T/T mispair.','2013-10-27','NSRP'),(19129,35488,'cytosine/thymine mispair binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a C/T mispair.','2013-10-27','NSRP'),(19130,35489,'guanine/guanine mispair binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a G/G mispair.','2013-10-27','NSRP'),(19131,35490,'regulation of leukotriene production involved in inflammatory response','P','Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.','2013-10-27','NSRP'),(19132,35491,'positive regulation of leukotriene production involved in inflammatory response','P','Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.','2013-10-27','NSRP'),(19133,35492,'negative regulation of leukotriene production involved in inflammatory response','P','Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.','2013-10-27','NSRP'),(19134,35493,'SNARE complex assembly','P','The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.','2013-10-27','NSRP'),(19135,35494,'SNARE complex disassembly','P','The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.','2013-10-27','NSRP'),(19136,35495,'regulation of SNARE complex disassembly','P','Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.','2013-10-27','NSRP'),(19137,35496,'lipopolysaccharide-1,5-galactosyltransferase activity','F','Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide.','2013-10-27','NSRP'),(19138,35497,'cAMP response element binding','F','Interacting selectively and non-covalently with the cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.','2013-10-27','NSRP'),(19139,35498,'carnosine metabolic process','P','The chemical reactions and pathways involving the dipeptide beta-alanyl-L-histidine (carnosine).','2013-10-27','NSRP'),(19140,35499,'carnosine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine).','2013-10-27','NSRP'),(19141,35500,'MH2 domain binding','F','Interacting selectively and non-covalently with the MH2 (MAD homology 2) domain of a protein. The MH2 domain is found at the carboxy terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.','2013-10-27','NSRP'),(19142,35501,'MH1 domain binding','F','Interacting selectively and non-covalently with the MH1 (MAD homology 1) domain of a protein. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors.','2013-10-27','NSRP'),(19143,35502,'metanephric part of ureteric bud development','P','The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros.','2013-10-27','NSRP'),(19144,35503,'ureter part of ureteric bud development','P','The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter.','2013-10-27','NSRP'),(19145,35504,'regulation of myosin light chain kinase activity','P','Any process that modulates the frequency, rate or extent of myosin light chain kinase activity.','2013-10-27','NSRP'),(19146,35505,'positive regulation of myosin light chain kinase activity','P','Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.','2013-10-27','NSRP'),(19147,35506,'negative regulation of myosin light chain kinase activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity.','2013-10-27','NSRP'),(19148,35507,'regulation of myosin-light-chain-phosphatase activity','P','Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity.','2013-10-27','NSRP'),(19149,35508,'positive regulation of myosin-light-chain-phosphatase activity','P','Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity.','2013-10-27','NSRP'),(19150,35509,'negative regulation of myosin-light-chain-phosphatase activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.','2013-10-27','NSRP'),(19151,35510,'DNA dealkylation','P','The removal of an alkyl group from one or more nucleotides within an DNA molecule.','2013-10-27','NSRP'),(19152,35511,'oxidative DNA demethylation','P','Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.','2013-10-27','NSRP'),(19153,35512,'hydrolytic DNA demethylation','P','The hydrolytic removal of the methyl group from one or more nucleotides within a DNA molecule.','2013-10-27','NSRP'),(19154,35513,'oxidative RNA demethylation','P','The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms.','2013-10-27','NSRP'),(19155,35514,'DNA demethylase activity','F','Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule.','2013-10-27','NSRP'),(19156,35515,'oxidative RNA demethylase activity','F','Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.','2013-10-27','NSRP'),(19157,35516,'oxidative DNA demethylase activity','F','Catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.','2013-10-27','NSRP'),(19158,35517,'PR-DUB complex','C','A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.','2013-10-27','NSRP'),(19159,35518,'histone H2A monoubiquitination','P','The modification of histone H2A by addition of a single ubiquitin group.','2013-10-27','NSRP'),(19160,35519,'protein K29-linked ubiquitination','P','A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation.','2013-10-27','NSRP'),(19161,35520,'monoubiquitinated protein deubiquitination','P','The removal of the ubiquitin group from a monoubiquitinated protein.','2013-10-27','NSRP'),(19162,35521,'monoubiquitinated histone deubiquitination','P','The removal of the ubiquitin group from a monoubiquitinated histone protein.','2013-10-27','NSRP'),(19163,35522,'monoubiquitinated histone H2A deubiquitination','P','The removal of the ubiquitin group from a monoubiquitinated histone H2A protein.','2013-10-27','NSRP'),(19164,35523,'protein K29-linked deubiquitination','P','A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein.','2013-10-27','NSRP'),(19165,35524,'proline transmembrane transport','P','The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19166,35525,'NF-kappaB p50/p65 complex','C','A heterodimer of NF-kappa B p50 and p65 subunits.','2013-10-27','NSRP'),(19167,35526,'retrograde transport, plasma membrane to Golgi','P','The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles.','2013-10-27','NSRP'),(19168,35527,'3-hydroxypropionate dehydrogenase (NADP+) activity','F','Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH.','2013-10-27','NSRP'),(19169,35528,'UDP-N-acetylglucosamine biosynthesis involved in chitin biosynthesis','P','The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine in glycosidic linkage with uridine diphosphate, that contribute to the biosynthesis of chitin.','2013-10-27','NSRP'),(19170,35529,'NADH pyrophosphatase activity','F','Catalysis of the reaction: NADH + H2O = AMP + NMNH + 2 H+.','2013-10-27','NSRP'),(19171,35530,'chemokine (C-C motif) ligand 6 production','P','The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(19172,35531,'regulation of chemokine (C-C motif) ligand 6 production','P','Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).','2013-10-27','NSRP'),(19173,35532,'negative regulation of chemokine (C-C motif) ligand 6 production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).','2013-10-27','NSRP'),(19174,35533,'positive regulation of chemokine (C-C motif) ligand 6 production','P','Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).','2013-10-27','NSRP'),(19175,35534,'chemokine (C-C motif) ligand 6 secretion','P','The regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell.','2013-10-27','NSRP'),(19176,35535,'regulation of chemokine (C-C motif) ligand 6 secretion','P','Any process that modulates the rate, frequency or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell.','2013-10-27','NSRP'),(19177,35536,'negative regulation of chemokine (C-C motif) ligand 6 secretion','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell.','2013-10-27','NSRP'),(19178,35537,'positive regulation of chemokine (C-C motif) ligand 6 secretion','P','Any process that activates or increases the frequency, rate, or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell.','2013-10-27','NSRP'),(19179,35538,'carbohydrate response element binding','F','Interacting selectively and non-covalently with the carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes.','2013-10-27','NSRP'),(19180,35539,'8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity','F','Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate + diphosphate. 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate, or 8-oxo-dGTP, is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.','2013-10-27','NSRP'),(19181,35540,'positive regulation of SNARE complex disassembly','P','Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.','2013-10-27','NSRP'),(19182,35541,'negative regulation of SNARE complex disassembly','P','Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.','2013-10-27','NSRP'),(19183,35542,'regulation of SNARE complex assembly','P','Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.','2013-10-27','NSRP'),(19184,35543,'positive regulation of SNARE complex assembly','P','Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.','2013-10-27','NSRP'),(19185,35544,'negative regulation of SNARE complex assembly','P','Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.','2013-10-27','NSRP'),(19186,35545,'determination of left/right asymmetry in nervous system','P','The establishment of the nervous system with respect to the left and right halves.','2013-10-27','NSRP'),(19187,35546,'interferon-beta secretion','P','The regulated release of interferon-beta from a cell.','2013-10-27','NSRP'),(19188,35547,'regulation of interferon-beta secretion','P','Any process that modulates the frequency, rate, or extent of interferon-beta secretion.','2013-10-27','NSRP'),(19189,35548,'negative regulation of interferon-beta secretion','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion.','2013-10-27','NSRP'),(19190,35549,'positive regulation of interferon-beta secretion','P','Any process that activates or increases the frequency, rate, or extent of interferon-beta secretion.','2013-10-27','NSRP'),(19191,35550,'urease complex','C','A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide).','2013-10-27','NSRP'),(19192,35551,'protein initiator methionine removal involved in protein maturation','P','Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein.','2013-10-27','NSRP'),(19193,35552,'oxidative single-stranded DNA demethylation','P','Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.','2013-10-27','NSRP'),(19194,35553,'oxidative single-stranded RNA demethylation','P','Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.','2013-10-27','NSRP'),(19195,35554,'termination of Roundabout signal transduction','P','The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated.','2013-10-27','NSRP'),(19196,35555,'initiation of Roundabout signal transduction','P','OBSOLETE. The process in which a SLIT protein causes activation of the receptor, Roundabout (ROBO).','2013-10-27','NSRP'),(19197,35556,'intracellular signal transduction','P','The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.','2013-10-27','NSRP'),(19198,35557,'intracellular signal transduction involved in cell surface receptor linked signaling','P','OBSOLETE. The process in which a signal is passed on from a receptor at the cell surface to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.','2013-10-27','NSRP'),(19199,35558,'phosphatidylinositol 3-kinase cascade involved in insulin receptor signaling','P','OBSOLETE. The process in which a signal is passed from the insulin receptor to components of the phosphatidylinositol 3-kinase (PI3K) cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.','2013-10-27','NSRP'),(19200,35559,'MAPKKK cascade involved in epidermal growth factor receptor signaling','P','OBSOLETE. The process in which a signal is passed from the epidermal growth factor receptor (EGFR) to components of the MAPKKK cascade, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.','2013-10-27','NSRP'),(19201,35560,'pheophoridase activity','F','Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a.','2013-10-27','NSRP'),(19202,35561,'regulation of chromatin binding','P','Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.','2013-10-27','NSRP'),(19203,35562,'negative regulation of chromatin binding','P','Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.','2013-10-27','NSRP'),(19204,35563,'positive regulation of chromatin binding','P','Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.','2013-10-27','NSRP'),(19205,35564,'regulation of kidney size','P','Any process that modulates the size of a kidney.','2013-10-27','NSRP'),(19206,35565,'regulation of pronephros size','P','Any process that modulates the size of a pronephric kidney.','2013-10-27','NSRP'),(19207,35566,'regulation of metanephros size','P','Any process that modulates the size of a metanephric kidney.','2013-10-27','NSRP'),(19208,35567,'non-canonical Wnt receptor signaling pathway','P','The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.','2013-10-27','NSRP'),(19209,35568,'N-terminal peptidyl-proline methylation','P','The methylation of the N-terminal proline of proteins.','2013-10-27','NSRP'),(19210,35569,'N-terminal peptidyl-proline trimethylation','P','The trimethylation of the N-terminal proline of proteins to form the derivative N,N,N-trimethylproline.','2013-10-27','NSRP'),(19211,35570,'N-terminal peptidyl-serine methylation','P','The methylation of the N-terminal serine of proteins.','2013-10-27','NSRP'),(19212,35571,'N-terminal peptidyl-serine monomethylation','P','The monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine.','2013-10-27','NSRP'),(19213,35572,'N-terminal peptidyl-serine dimethylation','P','The dimethylation of the N-terminal serine of proteins to form the derivative N,N-dimethylserine.','2013-10-27','NSRP'),(19214,35573,'N-terminal peptidyl-serine trimethylation','P','The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine.','2013-10-27','NSRP'),(19215,35574,'histone H4-K20 demethylation','P','The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone.','2013-10-27','NSRP'),(19216,35575,'histone demethylase activity (H4-K20 specific)','F','Catalysis of the reaction: histone H4 N6-methyl-L-lysine (position 20) + 2-oxoglutarate + O2 = histone H4 L-lysine (position 20) + succinate + formaldehyde + CO2. This reaction is the removal of a methyl group from lysine at position 20 of the histone H4 protein.','2013-10-27','NSRP'),(19217,35576,'retinoic acid receptor signaling pathway involved in pronephric field specification','P','The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in regions of the embryo being delineated into the area in which the pronephric kidney will develop.','2013-10-27','NSRP'),(19218,35577,'azurophil granule membrane','C','The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.','2013-10-27','NSRP'),(19219,35578,'azurophil granule lumen','C','The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.','2013-10-27','NSRP'),(19220,35579,'specific granule membrane','C','The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.','2013-10-27','NSRP'),(19221,35580,'specific granule lumen','C','The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.','2013-10-27','NSRP'),(19222,35581,'sequestering of extracellular ligand from receptor','P','The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.','2013-10-27','NSRP'),(19223,35582,'sequestering of BMP in extracellular matrix','P','Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.','2013-10-27','NSRP'),(19224,35583,'sequestering of TGFbeta in extracellular matrix','P','Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.','2013-10-27','NSRP'),(19225,35584,'calcium-mediated signaling using intracellular calcium source','P','A series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.','2013-10-27','NSRP'),(19226,35585,'calcium-mediated signaling using extracellular calcium source','P','A series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response.','2013-10-27','NSRP'),(19227,35586,'purinergic receptor activity','F','Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.','2013-10-27','NSRP'),(19228,35587,'purinergic receptor signaling pathway','P','The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative to initiate a change in cell activity.','2013-10-27','NSRP'),(19229,35588,'G-protein coupled purinergic receptor signaling pathway','P','The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine or purine derivative and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.','2013-10-27','NSRP'),(19230,35589,'G-protein coupled purinergic nucleotide receptor signaling pathway','P','The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.','2013-10-27','NSRP'),(19231,35590,'purinergic nucleotide receptor signaling pathway','P','The series of molecular signals generated as a consequence of a receptor binding to an extracellular purine nucleotide to initiate a change in cell activity.','2013-10-27','NSRP'),(19232,35591,'signaling adaptor activity','F','The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.','2013-10-27','NSRP'),(19233,35592,'establishment of protein localization to extracellular region','P','The directed movement of a protein to a specific location within the extracellular region.','2013-10-27','NSRP'),(19234,35593,'positive regulation of Wnt receptor signaling pathway by establishment of Wnt protein localization to extracellular region','P','Any process that activates or increases the frequency, rate or extent of the Wnt receptor signaling pathway by the directed movement of a Wnt protein within the extracellular region.','2013-10-27','NSRP'),(19235,35594,'ganglioside binding','F','Interacting selectively and non-covalently with a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues.','2013-10-27','NSRP'),(19236,35595,'N-acetylglucosaminylinositol deacetylase activity','F','Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol.','2013-10-27','NSRP'),(19237,35596,'methylthiotransferase activity','F','Catalysis of the addition of a methylthioether group (-SCH3) to a nucleic acid or protein acceptor.','2013-10-27','NSRP'),(19238,35597,'N6-isopentenyladenosine methylthiotransferase activity','F','Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).','2013-10-27','NSRP'),(19239,35598,'N6-threonylcarbomyladenosine methylthiotransferase activity','F','Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).','2013-10-27','NSRP'),(19240,35599,'aspartic acid methylthiotransferase activity','F','Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid.','2013-10-27','NSRP'),(19241,35600,'tRNA methylthiolation','P','The addition of a methylthioether group (-SCH3) to a nucleotide in a tRNA molecule.','2013-10-27','NSRP'),(19242,35601,'protein deacylation','P','The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid.','2013-10-27','NSRP'),(19243,35602,'fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow','P','The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow.','2013-10-27','NSRP'),(19244,35603,'fibroblast growth factor receptor signaling pathway involved in hemopoiesis','P','The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis.','2013-10-27','NSRP'),(19245,35604,'fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow','P','The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.','2013-10-27','NSRP'),(19246,35605,'peptidyl-cysteine S-nitrosylase activity','F','Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein.','2013-10-27','NSRP'),(19247,35606,'peptidyl-cysteine S-trans-nitrosylation','P','Transfer of a nitric oxide (NO) group from one cysteine residue to another.','2013-10-27','NSRP'),(19248,35607,'fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development','P','The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state.','2013-10-27','NSRP'),(19249,35608,'protein deglutamylation','P','The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation.','2013-10-27','NSRP'),(19250,35609,'C-terminal protein deglutamylation','P','The removal of a C-terminal, gene-encoded glutamate residue from a protein.','2013-10-27','NSRP'),(19251,35610,'protein side chain deglutamylation','P','The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation.','2013-10-27','NSRP'),(19252,35611,'protein branching point deglutamylation','P','The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue.','2013-10-27','NSRP'),(19253,35612,'AP-2 adaptor complex binding','F','Interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).','2013-10-27','NSRP'),(19254,35613,'RNA stem-loop binding','F','Interacting selectively and non-covalently with a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.','2013-10-27','NSRP'),(19255,35614,'snRNA stem-loop binding','F','Interacting selectively and non-covalently with a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.','2013-10-27','NSRP'),(19256,35615,'clathrin adaptor activity','F','The binding activity of a molecule that brings together clathrin and one or more other molecules, permitting them to function in a coordinated way.','2013-10-27','NSRP'),(19257,35616,'histone H2B conserved C-terminal lysine deubiquitination','P','A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals.','2013-10-27','NSRP'),(19258,35617,'stress granule disassembly','P','The disaggregation of a stress granule into its constituent protein and RNA parts.','2013-10-27','NSRP'),(19259,35618,'root hair','C','A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall.','2013-10-27','NSRP'),(19260,35619,'root hair tip','C','The tip portion of an outgrowth of a root epidermal cell.','2013-10-27','NSRP'),(19261,35620,'ceramide transporter activity','F','Enables the directed movement of ceramides into, out of or within a cell, or between cells. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.','2013-10-27','NSRP'),(19262,35621,'ER to Golgi ceramide transport','P','The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.','2013-10-27','NSRP'),(19263,35622,'intrahepatic bile duct development','P','The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).','2013-10-27','NSRP'),(19264,35623,'renal glucose absorption','P','A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron.','2013-10-27','NSRP'),(19265,35624,'receptor transactivation','P','The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer.','2013-10-27','NSRP'),(19266,35625,'epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway','P','The process in which an epidermal growth factor-activated receptor is activated via signaling events from a G-protein coupled receptor. This is an example of cross-talk between the EGF and GPCR signaling pathways.','2013-10-27','NSRP'),(19267,35626,'juvenile hormone mediated signaling pathway','P','A series of molecular signals initiated by the binding of juvenile hormone to a receptor, and ending with regulation of cell state or activity.','2013-10-27','NSRP'),(19268,35627,'ceramide transport','P','The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.','2013-10-27','NSRP'),(19269,35628,'cystic duct development','P','The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gall bladder to the common bile duct.','2013-10-27','NSRP'),(19270,35629,'N-terminal protein amino acid N-linked glycosylation','P','Addition of a carbohydrate or carbohydrate derivative unit via a nitrogen (N) atom of the N-terminal amino acid of a protein.','2013-10-27','NSRP'),(19271,35630,'bone mineralization involved in bone maturation','P','The deposition of calcium phosphate in bone tissue, involved in the progression of the skeleton from its formation to its mature state.','2013-10-27','NSRP'),(19272,35631,'CD40 receptor complex','C','A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules.','2013-10-27','NSRP'),(19273,35632,'mitochondrial prohibitin complex','C','A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death.','2013-10-27','NSRP'),(19274,35633,'maintenance of blood-brain barrier','P','Preserving the permeability barrier between the blood and the brain in a stable functional or structural state. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier.','2013-10-27','NSRP'),(19275,35634,'response to stilbenoid','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.','2013-10-27','NSRP'),(19276,35635,'entry of bacterium into host cell','P','The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(19277,35636,'multi-organism signaling','P','The transfer of information between living organisms.','2013-10-27','NSRP'),(19278,35637,'multicellular organismal signaling','P','The transfer of information occurring at the level of a multicellular organism.','2013-10-27','NSRP'),(19279,35638,'signal maturation','P','Any process leading to the attainment of the full functional capacity of a signal. A signal is a physical entity or change in state that is used to transfer information to trigger a response, and is functional when it can activate a receptor.','2013-10-27','NSRP'),(19280,35639,'purine ribonucleoside triphosphate binding','F','Interacting selectively and non-covalently with a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.','2013-10-27','NSRP'),(19281,35640,'exploration behavior','P','The specific behavior of an organism in response to a novel environment or stimulus.','2013-10-27','NSRP'),(19282,35641,'locomotory exploration behavior','P','The specific movement from place to place of an organism in response to a novel environment.','2013-10-27','NSRP'),(19283,35642,'histone methyltransferase activity (H3-R17 specific)','F','Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3.','2013-10-27','NSRP'),(19284,35643,'L-DOPA receptor activity','F','Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine.','2013-10-27','NSRP'),(19285,35644,'phosphoanandamide dephosphorylation','P','The process of removing one or more phosphate groups from a phosphorylated anandamide.','2013-10-27','NSRP'),(19286,35645,'enteric smooth muscle cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine.','2013-10-27','NSRP'),(19287,35646,'endosome to melanosome transport','P','The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle.','2013-10-27','NSRP'),(19288,35647,'3-oxo-delta(4,5)-steroid 5-beta-reductase activity','F','Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H(+) = a 5-beta-3-oxo-steroid + NADP(+).','2013-10-27','NSRP'),(19289,35648,'circadian mating behavior','P','The fluctuation in mating behavior that occurs over an approximately 24 hour cycle.','2013-10-27','NSRP'),(19290,35649,'Nrd1 complex','C','A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p.','2013-10-27','NSRP'),(19291,35650,'AP-1 adaptor complex binding','F','Interacting selectively and non-covalently with the AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).','2013-10-27','NSRP'),(19292,35651,'AP-3 adaptor complex binding','F','Interacting selectively and non-covalently with the AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).','2013-10-27','NSRP'),(19293,35652,'cargo loading into clathrin-coated vesicle','P','Formation of a protein complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins that are going to be transported by a vesicle.','2013-10-27','NSRP'),(19294,35653,'cargo loading into clathrin-coated vesicle, AP-1-mediated','P','Formation of a protein complex between proteins of the AP-1 adaptor complex and proteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking.','2013-10-27','NSRP'),(19295,35654,'cargo loading into clathrin-coated vesicle, AP-3-mediated','P','Formation of a protein complex between proteins of the AP-3 adaptor complex and proteins that are going to be transported by a clathrin-coated vesicle. In some cases, The AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle.','2013-10-27','NSRP'),(19296,35655,'interleukin-18-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19297,35656,'kinesin-associated melanosomal adaptor activity','F','The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to melanosomes.','2013-10-27','NSRP'),(19298,35657,'eRF1 methyltransferase complex','C','A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p.','2013-10-27','NSRP'),(19299,35658,'Mon1-Ccz1 complex','C','A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p.','2013-10-27','NSRP'),(19300,35659,'Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells','P','The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis.','2013-10-27','NSRP'),(19301,35660,'MyD88-dependent toll-like receptor 4 signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.','2013-10-27','NSRP'),(19302,35661,'MyD88-dependent toll-like receptor 2 signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response.','2013-10-27','NSRP'),(19303,35662,'Toll-like receptor 4 binding','F','Interacting selectively and non-covalently with a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response.','2013-10-27','NSRP'),(19304,35663,'Toll-like receptor 2 binding','F','Interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.','2013-10-27','NSRP'),(19305,35664,'TIRAP-dependent toll-like receptor signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.','2013-10-27','NSRP'),(19306,35665,'TIRAP-dependent toll-like receptor 4 signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.','2013-10-27','NSRP'),(19307,35666,'TRIF-dependent toll-like receptor signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.','2013-10-27','NSRP'),(19308,35667,'TRIF-dependent toll-like receptor 4 signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.','2013-10-27','NSRP'),(19309,35668,'TRAM-dependent toll-like receptor signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.','2013-10-27','NSRP'),(19310,35669,'TRAM-dependent toll-like receptor 4 signaling pathway','P','Any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.','2013-10-27','NSRP'),(19311,35670,'plant-type ovary development','P','The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed.','2013-10-27','NSRP'),(19312,35671,'enone reductase activity','F','Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+.','2013-10-27','NSRP'),(19313,35672,'oligopeptide transmembrane transport','P','The directed movement of an oligopeptide across a membrane by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.','2013-10-27','NSRP'),(19314,35673,'oligopeptide transmembrane transporter activity','F','Catalysis of the transfer of oligopeptides from one side of the membrane to the other.','2013-10-27','NSRP'),(19315,35674,'tricarboxylic acid transmembrane transport','P','The process in which tricarboxylic acids are transported from one side of a membrane to the other by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19316,35675,'neuromast hair cell development','P','The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.','2013-10-27','NSRP'),(19317,35676,'anterior lateral line neuromast hair cell development','P','The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.','2013-10-27','NSRP'),(19318,35677,'posterior lateral line neuromast hair cell development','P','The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.','2013-10-27','NSRP'),(19319,35678,'neuromast hair cell morphogenesis','P','The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.','2013-10-27','NSRP'),(19320,35679,'anterior lateral line neuromast hair cell morphogenesis','P','The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.','2013-10-27','NSRP'),(19321,35680,'posterior lateral line neuromast hair cell morphogenesis','P','The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.','2013-10-27','NSRP'),(19322,35681,'toll-like receptor 15 signaling pathway','P','Any series of molecular signals generated as a consequence of binding to toll-like receptor 15.','2013-10-27','NSRP'),(19323,35682,'toll-like receptor 21 signaling pathway','P','Any series of molecular signals generated as a consequence of binding to toll-like receptor 21.','2013-10-27','NSRP'),(19324,35683,'memory T cell extravasation','P','The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive.','2013-10-27','NSRP'),(19325,35684,'helper T cell extravasation','P','The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells.','2013-10-27','NSRP'),(19326,35685,'helper T cell diapedesis','P','The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.','2013-10-27','NSRP'),(19327,35686,'sperm fibrous sheath','C','A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.','2013-10-27','NSRP'),(19328,35687,'T-helper 1 cell extravasation','P','The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.','2013-10-27','NSRP'),(19329,35688,'T-helper 1 cell diapedesis','P','The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.','2013-10-27','NSRP'),(19330,35689,'chemokine (C-C motif) ligand 5 signaling pathway','P','A series of molecular signals initiated by the binding of the chemokine CCL5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19331,35690,'cellular response to drug','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.','2013-10-27','NSRP'),(19332,35691,'macrophage migration inhibitory factor signaling pathway','P','A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19333,35692,'macrophage migration inhibitory factor receptor complex','C','A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins.','2013-10-27','NSRP'),(19334,35693,'NOS2-CD74 complex','C','A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases.','2013-10-27','NSRP'),(19335,35694,'mitochondrial protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure.','2013-10-27','NSRP'),(19336,35695,'mitochondrion degradation by induced vacuole formation','P','The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes.','2013-10-27','NSRP'),(19337,35696,'monocyte extravasation','P','The migration of a monocyte from the blood vessels into the surrounding tissue.','2013-10-27','NSRP'),(19338,35697,'CD8-positive, alpha-beta T cell extravasation','P','The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue.','2013-10-27','NSRP'),(19339,35698,'CD8-positive, alpha-beta cytotoxic T cell extravasation','P','The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue.','2013-10-27','NSRP'),(19340,35699,'T-helper 17 cell extravasation','P','The migration of a T-helper 17 cell from the blood vessels into the surrounding tissue.','2013-10-27','NSRP'),(19341,35700,'astrocyte chemotaxis','P','The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).','2013-10-27','NSRP'),(19342,35701,'hematopoietic stem cell migration','P','The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.','2013-10-27','NSRP'),(19343,35702,'monocyte homeostasis','P','The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.','2013-10-27','NSRP'),(19344,35703,'monocyte migration into blood stream','P','The movement of a monocyte from the bone marrow to the blood stream.','2013-10-27','NSRP'),(19345,35704,'helper T cell chemotaxis','P','The directed movement of a helper T cell in response to an external stimulus.','2013-10-27','NSRP'),(19346,35705,'T-helper 17 cell chemotaxis','P','The directed movement of a T-helper 17 cell in response to an external stimulus.','2013-10-27','NSRP'),(19347,35706,'T-helper 1 cell chemotaxis','P','The directed movement of a T-helper 1 cell in response to an external stimulus.','2013-10-27','NSRP'),(19348,35707,'T-helper 2 cell chemotaxis','P','The directed movement of a T-helper 2 cell in response to an external stimulus.','2013-10-27','NSRP'),(19349,35708,'interleukin-4-dependent isotype switching to IgE isotypes','P','The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5\' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4).','2013-10-27','NSRP'),(19350,35709,'memory T cell activation','P','The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.','2013-10-27','NSRP'),(19351,35710,'CD4-positive, alpha-beta T cell activation','P','The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.','2013-10-27','NSRP'),(19352,35711,'T-helper 1 cell activation','P','The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.','2013-10-27','NSRP'),(19353,35712,'T-helper 2 cell activation','P','The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.','2013-10-27','NSRP'),(19354,35713,'response to nitrogen dioxide','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.','2013-10-27','NSRP'),(19355,35714,'cellular response to nitrogen dioxide','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.','2013-10-27','NSRP'),(19356,35715,'chemokine (C-C motif) ligand 2 binding','F','Interacting selectively and non-covalently with chemokine (C-C motif) ligand 2.','2013-10-27','NSRP'),(19357,35716,'chemokine (C-C motif) ligand 12 binding','F','Interacting selectively and non-covalently with chemokine (C-C motif) ligand 12.','2013-10-27','NSRP'),(19358,35717,'chemokine (C-C motif) ligand 7 binding','F','Interacting selectively and non-covalently with chemokine (C-C motif) ligand 7.','2013-10-27','NSRP'),(19359,35718,'macrophage migration inhibitory factor binding','F','Interacting selectively and non-covalently with the cytokine, macrophage migration inhibitory factor.','2013-10-27','NSRP'),(19360,35719,'tRNA import into nucleus','P','The directed movement of tRNA from the cytoplasm to the nucleus.','2013-10-27','NSRP'),(19361,35720,'intraflagellar anterograde transport','P','The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium or flagellum, mediated by motor proteins.','2013-10-27','NSRP'),(19362,35721,'intraflagellar retrograde transport','P','The directed movement of large protein complexes along microtubules from the tip of a cilium or flagellum toward the cell body, mediated by motor proteins.','2013-10-27','NSRP'),(19363,35722,'interleukin-12-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19364,35723,'interleukin-15-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19365,35724,'CD24 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation.','2013-10-27','NSRP'),(19366,35725,'sodium ion transmembrane transport','P','A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19367,35726,'common myeloid progenitor cell proliferation','P','The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.','2013-10-27','NSRP'),(19368,35727,'lysophosphatidic acid binding','F','Interacting selectively and non-covalently with lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G-protein-coupled receptors.','2013-10-27','NSRP'),(19369,35728,'response to hepatocyte growth factor stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.','2013-10-27','NSRP'),(19370,35729,'cellular response to hepatocyte growth factor stimulus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.','2013-10-27','NSRP'),(19371,35730,'S-nitrosoglutathione binding','F','Interacting selectively and non-covalently with S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems.','2013-10-27','NSRP'),(19372,35731,'dinitrosyl-iron complex binding','F','Interacting selectively and non-covalently with a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.','2013-10-27','NSRP'),(19373,35732,'nitric oxide storage','P','The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins.','2013-10-27','NSRP'),(19374,35733,'hepatic stellate cell activation','P','A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor.','2013-10-27','NSRP'),(19375,35734,'intraflagellar transport involved in cilium organisation','P','The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium organization.','2013-05-06','NSRP'),(19376,35735,'intraflagellar transport involved in cilium morphogenesis','P','The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium morphogenesis.','2013-10-27','NSRP'),(19377,35736,'cell proliferation involved in compound eye morphogenesis','P','The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis.','2013-10-27','NSRP'),(19378,35737,'injection of substance in to other organism','P','The process of forcing a substance into another organism, either by penetrating the skin of the other organism or by applying the substance externally to a sensitive tissue such as those that surround the eyes.','2013-10-27','NSRP'),(19379,35738,'envenomation resulting in modification of morphology or physiology of other organism','P','The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism.','2013-10-27','NSRP'),(19380,35739,'CD4-positive, alpha-beta T cell proliferation','P','The expansion of a CD4-positive, alpha-beta T cell population by cell division.','2013-10-27','NSRP'),(19381,35740,'CD8-positive, alpha-beta T cell proliferation','P','The expansion of a CD8-positive, alpha-beta T cell population by cell division.','2013-10-27','NSRP'),(19382,35741,'activated CD4-positive, alpha-beta T cell proliferation','P','The expansion of an activated CD4-positive, alpha-beta T cell population by cell division.','2013-10-27','NSRP'),(19383,35742,'activated CD8-positive, alpha-beta T cell proliferation','P','The expansion of an activated CD8-positive, alpha-beta T cell population by cell division.','2013-10-27','NSRP'),(19384,35743,'CD4-positive, alpha-beta T cell cytokine production','P','Any process that contributes to cytokine production by a CD4-positive, alpha-beta T cell.','2013-10-27','NSRP'),(19385,35744,'T-helper 1 cell cytokine production','P','Any process that contributes to cytokine production by a T-helper 1 cell.','2013-10-27','NSRP'),(19386,35745,'T-helper 2 cell cytokine production','P','Any process that contributes to cytokine production by a T-helper 2 cell.','2013-10-27','NSRP'),(19387,35746,'granzyme A production','P','The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(19388,35747,'natural killer cell chemotaxis','P','The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).','2013-10-27','NSRP'),(19389,35748,'myelin sheath abaxonal region','C','The region of the myelin sheath furthest from the axon.','2013-10-27','NSRP'),(19390,35749,'myelin sheath adaxonal region','C','The region of the myelin sheath nearest to the axon.','2013-10-27','NSRP'),(19391,35750,'protein localization to myelin sheath abaxonal region','P','Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon.','2013-10-27','NSRP'),(19392,35751,'regulation of lysosomal lumen pH','P','Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.','2013-10-27','NSRP'),(19393,35752,'lysosomal lumen pH elevation','P','Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.','2013-10-27','NSRP'),(19394,35753,'maintenance of DNA trinucleotide repeats','P','Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs.','2013-10-27','NSRP'),(19395,35754,'B cell chemotaxis','P','The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).','2013-10-27','NSRP'),(19396,35755,'cardiolipin hydrolase activity','F','Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol) to form phosphatidic acid (PA).','2013-10-27','NSRP'),(19397,35756,'transepithelial migration of symbiont in host','P','The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(19398,35757,'chemokine (C-C motif) ligand 19 binding','F','Interacting selectively and non-covalently with chemokine (C-C motif) ligand 19.','2013-10-27','NSRP'),(19399,35758,'chemokine (C-C motif) ligand 21 binding','F','Interacting selectively and non-covalently with chemokine (C-C motif) ligand 21.','2013-10-27','NSRP'),(19400,35759,'mesangial cell-matrix adhesion','P','The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney.','2013-10-27','NSRP'),(19401,35760,'cytoplasmic polyadenylation-dependent rRNA catabolic process','P','The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3\' end the target rRNA truncated degradation intermediate.','2013-10-27','NSRP'),(19402,35761,'dorsal motor nucleus of vagus nerve maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state.','2013-10-27','NSRP'),(19403,35762,'dorsal motor nucleus of vagus nerve morphogenesis','P','The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form.','2013-10-27','NSRP'),(19404,35763,'dorsal motor nucleus of vagus nerve structural organization','P','The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure.','2013-10-27','NSRP'),(19405,35764,'dorsal motor nucleus of vagus nerve formation','P','The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts.','2013-10-27','NSRP'),(19406,35765,'motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation','P','The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve.','2013-10-27','NSRP'),(19407,35766,'cell chemotaxis to fibroblast growth factor','P','The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF).','2013-10-27','NSRP'),(19408,35767,'endothelial cell chemotaxis','P','The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).','2013-10-27','NSRP'),(19409,35768,'endothelial cell chemotaxis to fibroblast growth factor','P','The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF).','2013-10-27','NSRP'),(19410,35769,'B cell chemotaxis across high endothelial venule','P','The movement of a B cell to cross a high endothelial venule in response to an external stimulus.','2013-10-27','NSRP'),(19411,35770,'ribonucleoprotein granule','C','A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.','2013-10-27','NSRP'),(19412,35771,'interleukin-4-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19413,35772,'interleukin-13-mediated signaling pathway','P','A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19414,35773,'insulin secretion involved in cellular response to glucose stimulus','P','The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.','2013-10-27','NSRP'),(19415,35774,'positive regulation of insulin secretion involved in cellular response to glucose stimulus','P','Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.','2013-10-27','NSRP'),(19416,35775,'pronephric glomerulus morphogenesis','P','The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.','2013-10-27','NSRP'),(19417,35776,'pronephric proximal tubule development','P','The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.','2013-10-27','NSRP'),(19418,35777,'pronephric distal tubule development','P','The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.','2013-10-27','NSRP'),(19419,35778,'pronephric nephron tubule epithelial cell differentiation','P','The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state.','2013-10-27','NSRP'),(19420,35779,'angioblast cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells).','2013-10-27','NSRP'),(19421,35780,'CD80 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival.','2013-10-27','NSRP'),(19422,35781,'CD86 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival.','2013-10-27','NSRP'),(19423,35782,'mature natural killer cell chemotaxis','P','The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules.','2013-10-27','NSRP'),(19424,35783,'CD4-positive, alpha-beta T cell costimulation','P','The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation.','2013-10-27','NSRP'),(19425,35784,'nickel cation homeostasis','P','Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell.','2013-10-27','NSRP'),(19426,35785,'cellular nickel ion homeostasis','P','Any process involved in the maintenance of an internal steady state of nickel ions at the level of a cell.','2013-10-27','NSRP'),(19427,35786,'protein complex oligomerization','P','The association of two or more multisubunit protein complexes to form dimers or other multimers of a protein complex.','2013-10-27','NSRP'),(19428,35787,'cell migration involved in kidney development','P','The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ.','2013-10-27','NSRP'),(19429,35788,'cell migration involved in metanephros development','P','The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ.','2013-10-27','NSRP'),(19430,35789,'metanephric mesenchymal cell migration','P','The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros.','2013-10-27','NSRP'),(19431,35790,'platelet-derived growth factor receptor-alpha signaling pathway','P','A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19432,35791,'platelet-derived growth factor receptor-beta signaling pathway','P','A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19433,35792,'other organism postsynaptic membrane','C','A postsynaptic membrane that is part of another organism, i.e. a secondary organism with which the first organism is interacting. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane.','2013-10-27','NSRP'),(19434,35793,'positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway','P','Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration as a result of the series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands.','2013-10-27','NSRP'),(19435,35794,'positive regulation of mitochondrial membrane permeability','P','Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.','2013-10-27','NSRP'),(19436,35795,'negative regulation of mitochondrial membrane permeability','P','Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.','2013-10-27','NSRP'),(19437,35796,'ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing','C','A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A\' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP.','2013-10-27','NSRP'),(19438,35797,'tellurite methyltransferase activity','F','Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride).','2013-10-27','NSRP'),(19439,35798,'2-alkenal reductase (NADP+) activity','F','Catalysis of the reaction: n-alkanal + NADP+ = alk-2-enal + NADPH + H+.','2013-10-27','NSRP'),(19440,35799,'ureter maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.','2013-10-27','NSRP'),(19441,35800,'ubiquitin-specific protease activator activity','F','Increases the activity of a ubiquitin-specific protease, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences.','2013-10-27','NSRP'),(19442,35801,'adrenal cortex development','P','The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens).','2013-10-27','NSRP'),(19443,35802,'adrenal cortex formation','P','The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).','2013-10-27','NSRP'),(19444,35803,'egg coat formation','P','Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.','2013-10-27','NSRP'),(19445,35804,'structural constituent of egg coat','F','The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.','2013-10-27','NSRP'),(19446,35805,'egg coat','C','A specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.','2013-10-27','NSRP'),(19447,35806,'modulation of blood coagulation in other organism','P','Any process in which an organism modulates the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.','2013-10-27','NSRP'),(19448,35807,'positive regulation of blood coagulation in other organism','P','Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.','2013-10-27','NSRP'),(19449,35808,'meiotic recombination initiation complex','C','A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins.','2013-10-27','NSRP'),(19450,35809,'regulation of urine volume','P','Any process that modulates the amount of urine excreted from the body over a unit of time.','2013-10-27','NSRP'),(19451,35810,'positive regulation of urine volume','P','Any process that increases the amount of urine excreted from the body over a unit of time.','2013-10-27','NSRP'),(19452,35811,'negative regulation of urine volume','P','Any process that decreases the amount of urine excreted from the body over a unit of time.','2013-10-27','NSRP'),(19453,35812,'renal sodium excretion','P','The elimination by an organism of sodium in the urine.','2013-10-27','NSRP'),(19454,35813,'regulation of renal sodium excretion','P','Any process that modulates the amount of sodium excreted in urine over a unit of time.','2013-10-27','NSRP'),(19455,35814,'negative regulation of renal sodium excretion','P','Any process that decreases the amount of sodium excreted in urine over a unit of time.','2013-10-27','NSRP'),(19456,35815,'positive regulation of renal sodium excretion','P','Any process that increases the amount of sodium excreted in urine over a unit of time.','2013-10-27','NSRP'),(19457,35816,'renal water absorption involved in negative regulation of urine volume','P','Any process where water is taken up from the collecting ducts and proximal and distal loops of the nephron, which acts to decrease the amount of urine that is excreted from the body per unit time.','2013-10-27','NSRP'),(19458,35817,'renal sodium ion absorption involved in negative regulation of renal sodium excretion','P','Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time.','2013-10-27','NSRP'),(19459,35818,'positive regulation of urine volume by pressure natriuresis','P','An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis.','2013-10-27','NSRP'),(19460,35819,'positive regulation of renal sodium excretion by pressure natriuresis','P','An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis.','2013-10-27','NSRP'),(19461,35820,'negative regulation of renal sodium excretion by angiotensin','P','The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time.','2013-10-27','NSRP'),(19462,35821,'modification of morphology or physiology of other organism','P','The process in which an organism effects a change in the structure or processes of a second organism.','2013-10-27','NSRP'),(19463,35822,'gene conversion','P','A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor.','2013-10-27','NSRP'),(19464,35823,'short tract gene conversion','P','A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor.','2013-10-27','NSRP'),(19465,35824,'long tract gene conversion','P','A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor.','2013-10-27','NSRP'),(19466,35825,'reciprocal DNA recombination','P','A DNA recombination process that results in the equal exchange of genetic material between the recombining DNA molecules.','2013-10-27','NSRP'),(19467,35826,'rubidium ion transport','P','The directed movement of rubidium ions (Rb+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19468,35827,'rubidium ion transmembrane transporter activity','F','Catalysis of the transfer of rubidium ions (Rb+) from one side of a membrane to the other.','2013-10-27','NSRP'),(19469,35828,'renal rubidium ion transport','P','The directed movement of rubidium ions (Rb+) by the kidney.','2013-10-27','NSRP'),(19470,35829,'renal rubidium ion absorption','P','A renal system process in which rubidium ions are taken up from the collecting ducts and proximal and distal loops of the nephron.','2013-10-27','NSRP'),(19471,35830,'palmatine metabolic process','P','The chemical reactions and pathways involving palmatine, a berberine alkaloid found in many plants.','2013-10-27','NSRP'),(19472,35831,'palmatine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of palmatine, a berberine alkaloid found in many plants.','2013-10-27','NSRP'),(19473,35832,'berbamunine metabolic process','P','The chemical reactions and pathways involving berbamunine, an isoquinoline alkaloid.','2013-10-27','NSRP'),(19474,35833,'berbamunine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid.','2013-10-27','NSRP'),(19475,35834,'indole alkaloid metabolic process','P','The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton.','2013-10-27','NSRP'),(19476,35835,'indole alkaloid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton.','2013-10-27','NSRP'),(19477,35836,'ergot alkaloid metabolic process','P','The chemical reactions and pathways involving an ergot alkaloid, an indole alkaloid.','2013-10-27','NSRP'),(19478,35837,'ergot alkaloid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an ergot alkaloid.','2013-10-27','NSRP'),(19479,35838,'growing cell tip','C','The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs.','2013-10-27','NSRP'),(19480,35839,'non-growing cell tip','C','A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures.','2013-10-27','NSRP'),(19481,35840,'old growing cell tip','C','A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.','2013-10-27','NSRP'),(19482,35841,'new growing cell tip','C','A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth.','2013-10-27','NSRP'),(19483,35842,'old cell tip after activation of bipolar cell growth','C','A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.','2013-10-27','NSRP'),(19484,35843,'endonuclear canal','C','A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope.','2013-10-27','NSRP'),(19485,35844,'cloaca development','P','The process whose specific outcome is the progression of the cloaca over time, from it\'s formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates.','2013-10-27','NSRP'),(19486,35845,'photoreceptor cell outer segment organization','P','A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.','2013-10-27','NSRP'),(19487,35846,'oviduct epithelium development','P','The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct.','2013-10-27','NSRP'),(19488,35847,'uterine epithelium development','P','The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.','2013-10-27','NSRP'),(19489,35848,'oviduct morphogenesis','P','The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism.','2013-10-27','NSRP'),(19490,35849,'nephric duct elongation','P','The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney.','2013-10-27','NSRP'),(19491,35850,'epithelial cell differentiation involved in kidney development','P','The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state.','2013-10-27','NSRP'),(19492,35851,'Krueppel-associated box domain binding','F','Interacting selectively and non-covalently with a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.','2013-10-27','NSRP'),(19493,35852,'horizontal cell localization','P','Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina.','2013-10-27','NSRP'),(19494,35853,'chromosome passenger complex localization to spindle midzone','P','A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap.','2013-10-27','NSRP'),(19495,35854,'eosinophil fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin.','2013-10-27','NSRP'),(19496,35855,'megakaryocyte development','P','The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.','2013-10-27','NSRP'),(19497,35856,'eosinophil development','P','The process whose specific outcome is the progression of an eosinophil cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a eosinophil cell fate.','2013-04-22','NSRP'),(19498,35857,'eosinophil fate specification','P','The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.','2013-10-27','NSRP'),(19499,35858,'eosinophil fate determination','P','The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(19500,35859,'Seh1-associated complex','C','A protein complex that associates dynamically with the vacuolar membrane, and is proposed to have a role in membrane-associated trafficking or regulatory processes. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.','2013-10-27','NSRP'),(19501,35860,'glial cell-derived neurotrophic factor receptor signaling pathway','P','The series of molecular signals generated as a consequence of a glial cell-derived neurotrophic factor receptor binding to one of its physiological ligands.','2013-10-27','NSRP'),(19502,35861,'site of double-strand break','C','A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.','2013-10-27','NSRP'),(19503,35862,'dITP metabolic process','P','The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2\'-deoxyinosine 5\'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5\'-position.','2013-10-27','NSRP'),(19504,35863,'dITP catabolic process','P','The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5\'-position.','2013-10-27','NSRP'),(19505,35864,'response to potassium ion','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.','2013-10-27','NSRP'),(19506,35865,'cellular response to potassium ion','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.','2013-10-27','NSRP'),(19507,35866,'alphav-beta3 integrin-PKCalpha complex','C','A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.','2013-10-27','NSRP'),(19508,35867,'alphav-beta3 integrin-IGF-1-IGF1R complex','C','A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits.','2013-10-27','NSRP'),(19509,35868,'alphav-beta3 integrin-HMGB1 complex','C','A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein.','2013-10-27','NSRP'),(19510,35869,'ciliary transition zone','C','A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition.','2013-10-27','NSRP'),(19511,35870,'dITP diphosphatase activity','F','Catalysis of the reaction: dITP + H2O = dIMP + diphosphate.','2013-10-27','NSRP'),(19512,35871,'protein K11-linked deubiquitination','P','A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein.','2013-10-27','NSRP'),(19513,35872,'nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway','P','A series of molecular signals generated as a consequence of a nucleotide-binding domain, leucine rich repeat containing receptor (NLR) binding to one of its physiological ligands. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number. The NLR signaling pathway begins with binding of a ligand to a NLR receptor and ends with regulation of a downstream cellular process.','2013-10-27','NSRP'),(19514,35873,'lactate transmembrane transport','P','The directed movement of lactate across a membrane by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.','2013-10-27','NSRP'),(19515,35874,'cellular response to copper ion starvation','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions.','2013-10-27','NSRP'),(19516,35875,'maintenance of meiotic sister chromatid cohesion, centromeric','P','The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle.','2013-10-27','NSRP'),(19517,35876,'maintenance of meiotic sister chromatid cohesion, arms','P','The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle.','2013-10-27','NSRP'),(19518,35877,'death effector domain binding','F','Interacting selectively and non-covalently with a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).','2013-10-27','NSRP'),(19519,35878,'nail development','P','The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it.','2013-10-27','NSRP'),(19520,35879,'plasma membrane lactate transport','P','The directed movement of lactate across a plasma membrane.','2013-10-27','NSRP'),(19521,35880,'embryonic nail plate morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits.','2013-10-27','NSRP'),(19522,35881,'amacrine cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.','2013-10-27','NSRP'),(19523,35882,'defecation rhythm','P','The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated.','2013-10-27','NSRP'),(19524,35883,'enteroendocrine cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.','2013-10-27','NSRP'),(19525,35884,'arabinan biosynthetic process','P','The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues.','2013-10-27','NSRP'),(19526,35885,'exochitinase activity','F','Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain.','2013-10-27','NSRP'),(19527,35886,'vascular smooth muscle cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.','2013-10-27','NSRP'),(19528,35887,'aortic smooth muscle cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta.','2013-10-27','NSRP'),(19529,35888,'isoguanine deaminase activity','F','Catalysis of the reaction: isoguanine + H2O = xanthine + NH3.','2013-10-27','NSRP'),(19530,35889,'otolith tethering','P','The attachment of a developing otolith to the kinocilia of tether cells in the inner ear.','2013-10-27','NSRP'),(19531,35890,'exit from host','P','The directed movement of an organism out of the body, tissues or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(19532,35891,'exit from host cell','P','The directed movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(19533,35892,'modulation of platelet aggregation in other organism','P','Any process in which an organism modulates the frequency, rate or extent of platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.','2013-10-27','NSRP'),(19534,35893,'negative regulation of platelet aggregation in other organism','P','Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism.','2013-10-27','NSRP'),(19535,35894,'positive regulation of platelet aggregation in other organism','P','Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism.','2013-10-27','NSRP'),(19536,35895,'modulation of mast cell degranulation in other organism','P','Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.','2013-10-27','NSRP'),(19537,35896,'positive regulation of mast cell degranulation in other organism','P','Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism.','2013-10-27','NSRP'),(19538,35897,'proteolysis in other organism','P','The chemical reactions and pathways performed by an organism resulting in the hydrolysis of proteins in another organism by cleavage of their peptide bonds.','2013-10-27','NSRP'),(19539,35898,'parathyroid hormone secretion','P','The regulated release of parathyroid hormone into the circulatory system.','2013-10-27','NSRP'),(19540,35899,'negative regulation of blood coagulation in other organism','P','Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.','2013-10-27','NSRP'),(19541,35900,'response to isolation stress','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species.','2013-10-27','NSRP'),(19542,35901,'cellular response to isolation stress','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species.','2013-10-27','NSRP'),(19543,35902,'response to immobilization stress','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.','2013-10-27','NSRP'),(19544,35903,'cellular response to immobilization stress','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.','2013-10-27','NSRP'),(19545,35904,'aorta development','P','The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.','2013-10-27','NSRP'),(19546,35905,'ascending aorta development','P','The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.','2013-10-27','NSRP'),(19547,35906,'descending aorta development','P','The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.','2013-10-27','NSRP'),(19548,35907,'dorsal aorta development','P','The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.','2013-10-27','NSRP'),(19549,35908,'ventral aorta development','P','The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once.','2013-10-27','NSRP'),(19550,35909,'aorta morphogenesis','P','The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.','2013-10-27','NSRP'),(19551,35910,'ascending aorta morphogenesis','P','The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.','2013-10-27','NSRP'),(19552,35911,'descending aorta morphogenesis','P','The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.','2013-10-27','NSRP'),(19553,35912,'dorsal aorta morphogenesis','P','The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.','2013-10-27','NSRP'),(19554,35913,'ventral aorta morphogenesis','P','The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once.','2013-10-27','NSRP'),(19555,35914,'skeletal muscle cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.','2013-10-27','NSRP'),(19556,35915,'pore formation in membrane of other organism','P','The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism.','2013-10-27','NSRP'),(19557,35916,'modulation of calcium channel activity in other organism','P','Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism.','2013-10-27','NSRP'),(19558,35917,'negative regulation of calcium channel activity in other organism','P','Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism.','2013-10-27','NSRP'),(19559,35918,'negative regulation of voltage-gated calcium channel activity in other organism','P','Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(19560,35919,'negative regulation of low voltage-gated calcium channel activity in other organism','P','Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(19561,35920,'negative regulation of high voltage-gated calcium channel activity in other organism','P','Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(19562,35921,'desmosome disassembly','P','The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.','2013-10-27','NSRP'),(19563,35922,'foramen ovale closure','P','The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow.','2013-10-27','NSRP'),(19564,35923,'flurbiprofen binding','F','Interacting selectively and non-covalently with flurbiprofen.','2013-10-27','NSRP'),(19565,35924,'cellular response to vascular endothelial growth factor stimulus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.','2013-10-27','NSRP'),(19566,35925,'mRNA 3\'-UTR AU-rich region binding','F','Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3\' untranslated region of a mRNA molecule.','2013-10-27','NSRP'),(19567,35926,'chemokine (C-C motif) ligand 2 secretion','P','The regulated release of chemokine (C-C motif) ligand 2 (CCL2) from a cell.','2013-10-27','NSRP'),(19568,35927,'RNA import into mitochondrion','P','The directed movement of RNA from the cytoplasm into a mitochondrion.','2013-10-27','NSRP'),(19569,35928,'rRNA import into mitochondrion','P','The directed movement of rRNA, ribosomal ribonucleic acid, from the cytoplasm into a mitochondrion.','2013-10-27','NSRP'),(19570,35929,'steroid hormone secretion','P','The regulated release of any steroid that acts as a hormone into the circulatory system.','2013-10-27','NSRP'),(19571,35930,'corticosteroid hormone secretion','P','The regulated release of any corticosteroid hormone into the circulatory system.','2013-10-27','NSRP'),(19572,35931,'mineralocorticoid secretion','P','The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism.','2013-10-27','NSRP'),(19573,35932,'aldosterone secretion','P','The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.','2013-10-27','NSRP'),(19574,35933,'glucocorticoid secretion','P','The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood.','2013-10-27','NSRP'),(19575,35934,'corticosterone secretion','P','The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.','2013-10-27','NSRP'),(19576,35935,'androgen secretion','P','The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates.','2013-10-27','NSRP'),(19577,35936,'testosterone secretion','P','The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.','2013-10-27','NSRP'),(19578,35937,'estrogen secretion','P','The regulated release of estrogen into the circulatory system. Estrogen is a steroid hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals.','2013-10-27','NSRP'),(19579,35938,'estradiol secretion','P','The regulated release of estradiol into the circulatory system.','2013-10-27','NSRP'),(19580,35939,'microsatellite binding','F','Interacting selectively and non-covalently with a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem.','2013-10-27','NSRP'),(19581,35940,'negative regulation of peptidase activity in other organism','P','Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of peptidase activity, the catalysis of the hydrolysis of peptide bonds in a protein, in a second organism.','2013-10-27','NSRP'),(19582,35941,'androstenedione secretion','P','The regulated release of androstenedione (androst-4-ene-3,17-dione) into the circulatory system.','2013-10-27','NSRP'),(19583,35942,'dehydroepiandrosterone secretion','P','The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system.','2013-10-27','NSRP'),(19584,35943,'estrone secretion','P','The regulated release of estrone into the circulatory system.','2013-10-27','NSRP'),(19585,35944,'perforin production','P','The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.','2013-10-27','NSRP'),(19586,35945,'mitochondrial ncRNA surveillance','P','The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion.','2013-10-27','NSRP'),(19587,35946,'mitochondrial mRNA surveillance','P','The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion.','2013-10-27','NSRP'),(19588,35947,'regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter','P','Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19589,35948,'positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of gluconeogenesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19590,35949,'positive regulation of gluconeogenesis by negative regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of gluconeogenesis by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19591,35950,'regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter','P','Any process that modulates the frequency, rate or extent of oligopeptide transport, by regulation of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19592,35951,'positive regulation of oligopeptide transport by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of oligopeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19593,35952,'negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter','P','Any process that stops, prevents or reduces the frequency, rate or extent of oligopeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19594,35953,'regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter','P','Any process that modulates the frequency, rate or extent of dipeptide transport, by regulation of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19595,35954,'positive regulation of dipeptide transport by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of dipeptide transport by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19596,35955,'negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter','P','Any process that stops, prevents or reduces the frequency, rate or extent of dipeptide transport by stopping, preventing or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19597,35956,'regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter','P','Any process that modulates the frequency, rate or extent of the breakdown of starch, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19598,35957,'positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of the breakdown of starch, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19599,35958,'regulation of glyoxylate cycle by regulation of transcription from RNA polymerase II promoter','P','Any process that modulates the frequency, rate or extent of the glyoxylate cycle by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19600,35959,'positive regulation of glyoxylate cycle by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of the glyoxylate cycle by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19601,35960,'regulation of ergosterol biosynthetic process by regulation of transcription from RNA polymerase II promoter','P','Any process that modulates the frequency, rate or extent of ergosterol biosynthetic process by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19602,35961,'positive regulation of ergosterol biosynthetic process by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of ergosterol biosynthesis by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19603,35962,'response to interleukin-13','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.','2013-10-27','NSRP'),(19604,35963,'cellular response to interleukin-13','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.','2013-10-27','NSRP'),(19605,35964,'COPI-coated vesicle budding','P','The evagination of a Golgi membrane, resulting in formation of a COPI-coated vesicle.','2013-10-27','NSRP'),(19606,35965,'cardiolipin acyl-chain remodeling','P','Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids.','2013-10-27','NSRP'),(19607,35966,'response to topologically incorrect protein','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.','2013-10-27','NSRP'),(19608,35967,'cellular response to topologically incorrect protein','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.','2013-10-27','NSRP'),(19609,35968,'regulation of sterol import by regulation of transcription from RNA polymerase II promoter','P','Any process that modulates the frequency, rate or extent of sterol import, by regulation of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19610,35969,'positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter','P','Any process that activates or increases the frequency, rate or extent of sterol import by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.','2013-10-27','NSRP'),(19611,35970,'peptidyl-threonine dephosphorylation','P','The removal of phosphoric residues from peptidyl-O-phospho-L-threonine to form peptidyl-threonine.','2013-10-27','NSRP'),(19612,35971,'peptidyl-histidine dephosphorylation','P','The removal of phosphoric residues from peptidyl-O-phospho-L-histidine to form peptidyl-histidine.','2013-10-27','NSRP'),(19613,35973,'aggrephagy','P','Selective degradation of protein aggregates by macroautophagy.','2013-10-27','NSRP'),(19614,35974,'meiotic spindle pole body','C','The microtubule organizing center on a spindle that forms as part of meiosis; functionally homologous to the animal cell centrosome.','2013-10-27','NSRP'),(19615,35975,'carbamoyl phosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways.','2013-10-27','NSRP'),(19616,35976,'AP1 complex','C','A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.','2013-10-27','NSRP'),(19617,35977,'protein deglycosylation involved in glycoprotein catabolic process','P','The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein.','2013-10-27','NSRP'),(19618,35978,'histone H2A-S139 phosphorylation','P','The modification of histone H2A by the addition of an phosphate group to a serine residue at position 139 of the histone.','2013-10-27','NSRP'),(19619,35979,'histone kinase activity (H2A-S139 specific)','F','Catalysis of the transfer of a phosphate group to the serine-139 residue of the C-terminal tail of histone H2A.','2013-10-27','NSRP'),(19620,35980,'invasive growth in response to nitrogen limitation','P','OBSOLETE. The growth of colonies in filamentous chains of cells as a result of a reduced availability of nitrogen.','2013-10-27','NSRP'),(19621,35981,'tongue muscle cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell.','2013-10-27','NSRP'),(19622,35982,'age-dependent behavioral decline','P','A developmental process that arises as an organism progresses toward the end of its lifespan that results in a decline in behavioral activities such as locomotory behavior, and learning or memory.','2013-10-27','NSRP'),(19623,35983,'response to trichostatin A','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.','2013-10-27','NSRP'),(19624,35984,'cellular response to trichostatin A','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.','2013-10-27','NSRP'),(19625,35985,'senescence-associated heterochromatin focus','C','A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.','2013-10-27','NSRP'),(19626,35986,'senescence-associated heterochromatin focus assembly','P','The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes.','2013-10-27','NSRP'),(19627,35987,'endodermal cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.','2013-10-27','NSRP'),(19628,35988,'chondrocyte proliferation','P','The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.','2013-10-27','NSRP'),(19629,35989,'tendon development','P','The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.','2013-10-27','NSRP'),(19630,35990,'tendon cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.','2013-10-27','NSRP'),(19631,35991,'nitric oxide sensor activity','F','Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO).','2013-10-27','NSRP'),(19632,35992,'tendon formation','P','The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.','2013-10-27','NSRP'),(19633,35993,'deltoid tuberosity development','P','The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase.','2013-10-27','NSRP'),(19634,35994,'response to muscle stretch','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.','2013-10-27','NSRP'),(19635,35995,'detection of muscle stretch','P','The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(19636,38001,'paracrine signaling','P','The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.','2013-10-27','NSRP'),(19637,38002,'endocrine signaling','P','The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other.','2013-10-27','NSRP'),(19638,38003,'opioid receptor signaling pathway','P','The series of molecular signals generated as a consequence of an opioid receptor binding to one of its physiological ligands.','2013-10-27','NSRP'),(19639,38004,'epidermal growth factor receptor ligand maturation','P','Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor.','2013-10-27','NSRP'),(19640,38005,'peptide bond cleavage involved in epidermal growth factor receptor ligand maturation','P','The hydrolysis of a peptide bond or bonds within a ligand for the epidermal growth factor receptor, as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. In Drosophila for example, in the Golgi apparatus of the signal producing cell, Spitz is cleaved within its transmembrane domain to release a functional soluble extracellular fragment.','2013-10-27','NSRP'),(19641,38006,'netrin receptor activity involved in chemoattraction','F','Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin.','2013-10-27','NSRP'),(19642,38007,'netrin-activated signaling pathway','P','A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.','2013-10-27','NSRP'),(19643,38008,'TRAF-mediated signal transduction','P','The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components.','2013-10-27','NSRP'),(19644,38009,'regulation of signal transduction by receptor internalization','P','Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway.','2013-10-27','NSRP'),(19645,38010,'positive regulation of signal transduction by receptor internalization','P','Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms.','2013-10-27','NSRP'),(19646,38011,'negative regulation of signal transduction by receptor internalization','P','Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands.','2013-10-27','NSRP'),(19647,38012,'negative regulation of Wnt receptor signaling pathway by Wnt receptor internalization','P','Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt receptor signal transduction.','2013-10-27','NSRP'),(19648,38013,'positive regulation of Wnt receptor signaling pathway by Wnt receptor internalization','P','Any process in which internalization of a Wnt receptor activates or increases the frequency, rate or extent of the Wnt receptor signaling pathway.','2013-10-27','NSRP'),(19649,38014,'negative regulation of insulin receptor signaling pathway by insulin receptor internalization','P','Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation.','2013-10-27','NSRP'),(19650,38015,'positive regulation of insulin receptor signaling pathway by insulin receptor internalization','P','Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane.','2013-10-27','NSRP'),(19651,38016,'insulin receptor internalization','P','A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell.','2013-10-27','NSRP'),(19652,38017,'Wnt receptor internalization','P','A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell.','2013-10-27','NSRP'),(19653,38018,'Wnt receptor catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.','2013-10-27','NSRP'),(19654,38019,'Wnt receptor recycling','P','The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.','2013-10-27','NSRP'),(19655,38020,'insulin receptor recycling','P','The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.','2013-10-27','NSRP'),(19656,38021,'leptin receptor activity','F','Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(19657,38022,'G-protein coupled olfactory receptor activity','F','Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.','2013-10-27','NSRP'),(19658,38023,'signaling receptor activity','F','Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.','2013-10-27','NSRP'),(19659,38024,'cargo receptor activity','F','Combining selectively with an extracellular macromolecule and delivering the macromolecule into the cell via endocytosis.','2013-10-27','NSRP'),(19660,38025,'reelin receptor activity','F','Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(19661,38026,'reelin-mediated signaling pathway','P','A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19662,38027,'apolipoprotein A-I-mediated signaling pathway','P','A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(19663,39003,'pronephric field specification','P','The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop.','2013-10-27','NSRP'),(19664,39004,'specification of pronephric proximal tubule identity','P','The process in which the proximal tubule of the pronephric nephron acquires its identity.','2013-10-27','NSRP'),(19665,39005,'specification of pronephric tubule identity','P','The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity.','2013-10-27','NSRP'),(19666,39006,'pronephric nephron tubule formation','P','The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros.','2013-10-27','NSRP'),(19667,39007,'pronephric nephron morphogenesis','P','The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros.','2013-10-27','NSRP'),(19668,39008,'pronephric nephron tubule morphogenesis','P','The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron.','2013-10-27','NSRP'),(19669,39009,'rectal diverticulum development','P','The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior.','2013-10-27','NSRP'),(19670,39010,'specification of pronephric distal tubule identity','P','The process in which the distal tubule of the pronephric nephron acquires its identity.','2013-10-27','NSRP'),(19671,39011,'pronephric proximal tubule morphogenesis','P','The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.','2013-10-27','NSRP'),(19672,39012,'pronephric sinus development','P','The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules.','2013-10-27','NSRP'),(19673,39013,'pronephric distal tubule morphogenesis','P','The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.','2013-10-27','NSRP'),(19674,39014,'cell differentiation involved in pronephros development','P','The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state.','2013-10-27','NSRP'),(19675,39015,'cell proliferation involved in pronephros development','P','The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros.','2013-10-27','NSRP'),(19676,39016,'cell-cell signaling involved in pronephros development','P','Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ.','2013-10-27','NSRP'),(19677,39017,'pattern specification involved in pronephros development','P','Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate.','2013-10-27','NSRP'),(19678,39018,'nephrostome development','P','The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity.','2013-10-27','NSRP'),(19679,39019,'pronephric nephron development','P','The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros.','2013-10-27','NSRP'),(19680,39020,'pronephric nephron tubule development','P','The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct.','2013-10-27','NSRP'),(19681,39021,'pronephric glomerulus development','P','The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.','2013-10-27','NSRP'),(19682,39022,'pronephric duct development','P','The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney.','2013-10-27','NSRP'),(19683,39023,'pronephric duct morphogenesis','P','The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.','2013-10-27','NSRP'),(19684,39501,'suppression by virus of host type I interferon production','P','Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.','2013-10-27','NSRP'),(19685,39502,'suppression by virus of host type I interferon-mediated signaling pathway','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.','2013-10-27','NSRP'),(19686,39503,'suppression by virus of host innate immune response','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host\'s first line of defense.','2013-10-27','NSRP'),(19687,39504,'suppression by virus of host adaptive immune response','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).','2013-10-27','NSRP'),(19688,39505,'suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II','P','Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex.','2013-10-27','NSRP'),(19689,39506,'modulation by virus of host molecular function','P','The process in which a virus effects a change in the function of a host protein via a direct interaction.','2013-10-27','NSRP'),(19690,39507,'suppression by virus of host molecular function','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein.','2013-10-27','NSRP'),(19691,39508,'suppression by virus of host receptor activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor.','2013-10-27','NSRP'),(19692,39509,'suppression by virus of host pattern recognition receptor activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity.','2013-10-27','NSRP'),(19693,39510,'suppression by virus of host ATP-dependent RNA helicase activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ATP-dependent RNA helicase activity.','2013-10-27','NSRP'),(19694,39511,'suppression by virus of host interferon receptor activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor.','2013-10-27','NSRP'),(19695,39512,'suppression by virus of host protein tyrosine kinase activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity.','2013-10-27','NSRP'),(19696,39513,'suppression by virus of host catalytic activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity.','2013-10-27','NSRP'),(19697,39514,'suppression by virus of host JAK-STAT cascade','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signal cascade in the host organism.','2013-10-27','NSRP'),(19698,39515,'suppression by virus of tyrosine phosphorylation of host STAT protein','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent by which a phosphate group is introduced to a tyrosine residue of a host STAT (Signal Transducer and Activator of Transcription) protein.','2013-05-06','NSRP'),(19699,39516,'modulation by virus of host catalytic activity','P','The process in which a virus effects a change in host enzyme activity.','2013-10-27','NSRP'),(19700,39517,'modulation by virus of host protein serine/threonine phosphatase activity','P','The process in which a virus effects a change in host protein serine/threonine phosphatase activity.','2013-10-27','NSRP'),(19701,39518,'suppression by virus of host cytokine activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity.','2013-10-27','NSRP'),(19702,39519,'modulation by virus of host autophagy','P','Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host.','2013-10-27','NSRP'),(19703,39520,'induction by virus of host autophagy','P','Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.','2013-10-27','NSRP'),(19704,39521,'suppression by virus of host autophagy','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host.','2013-10-27','NSRP'),(19705,39522,'suppression by virus of host mRNA export from nucleus','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism.','2013-10-27','NSRP'),(19706,39523,'suppression by virus of host RNA polymerase II activity','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host RNA polymerase II activity.','2013-10-27','NSRP'),(19707,39524,'suppression by virus of host mRNA processing','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.','2013-10-27','NSRP'),(19708,39525,'modulation by virus of host chromatin organization','P','Any process in which a virus effects a change in the organization of chromatin in the host.','2013-10-27','NSRP'),(19709,39526,'modulation by virus of host apoptotic process','P','Any process in which a virus modulates the frequency, rate or extent of apoptosis of infected host cells.','2013-10-27','NSRP'),(19710,39527,'suppression by virus of host TRAF-mediated signal transduction','P','Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of TRAF-mediated signal transduction in the host.','2013-10-27','NSRP'),(19711,40001,'establishment of mitotic spindle localization','P','The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.','2013-10-27','NSRP'),(19712,40002,'collagen and cuticulin-based cuticle development','P','Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(19713,40003,'chitin-based cuticle development','P','Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(19714,40004,'collagen and cuticulin-based cuticle attachment to epithelium','P','Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(19715,40005,'chitin-based cuticle attachment to epithelium','P','Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(19716,40006,'protein-based cuticle attachment to epithelium','P','OBSOLETE. Attaching of a protein-based cuticle to the epithelium underlying it.','2013-10-27','NSRP'),(19717,40007,'growth','P','The increase in size or mass of an entire organism, a part of an organism or a cell.','2013-10-27','NSRP'),(19718,40008,'regulation of growth','P','Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism\'s development.','2013-10-27','NSRP'),(19719,40009,'regulation of growth rate','P','Any process that modulates the rate of growth of all or part of an organism.','2013-10-27','NSRP'),(19720,40010,'positive regulation of growth rate','P','Any process that increases the rate of growth of all or part of an organism.','2013-10-27','NSRP'),(19721,40011,'locomotion','P','Self-propelled movement of a cell or organism from one location to another.','2013-10-27','NSRP'),(19722,40012,'regulation of locomotion','P','Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.','2013-10-27','NSRP'),(19723,40013,'negative regulation of locomotion','P','Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.','2013-10-27','NSRP'),(19724,40014,'regulation of multicellular organism growth','P','Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.','2013-10-27','NSRP'),(19725,40015,'negative regulation of multicellular organism growth','P','Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.','2013-10-27','NSRP'),(19726,40016,'embryonic cleavage','P','The first few specialized divisions of an activated animal egg.','2013-10-27','NSRP'),(19727,40017,'positive regulation of locomotion','P','Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.','2013-10-27','NSRP'),(19728,40018,'positive regulation of multicellular organism growth','P','Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.','2013-10-27','NSRP'),(19729,40019,'positive regulation of embryonic development','P','Any process that activates or increases the frequency, rate or extent of embryonic development.','2013-10-27','NSRP'),(19730,40020,'regulation of meiosis','P','Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.','2013-10-27','NSRP'),(19731,40021,'hermaphrodite germ-line sex determination','P','The determination of sex and sexual phenotype in the germ line of a hermaphrodite.','2013-10-27','NSRP'),(19732,40022,'feminization of hermaphroditic germ-line','P','The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite.','2013-10-27','NSRP'),(19733,40023,'establishment of nucleus localization','P','The directed movement of the nucleus to a specific location within a cell.','2013-10-27','NSRP'),(19734,40024,'dauer larval development','P','The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.','2013-10-27','NSRP'),(19735,40025,'vulval development','P','The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.','2013-10-27','NSRP'),(19736,40026,'positive regulation of vulval development','P','Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.','2013-10-27','NSRP'),(19737,40027,'negative regulation of vulval development','P','Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.','2013-10-27','NSRP'),(19738,40028,'regulation of vulval development','P','Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.','2013-10-27','NSRP'),(19739,40029,'regulation of gene expression, epigenetic','P','Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence.','2013-10-27','NSRP'),(19740,40030,'regulation of molecular function, epigenetic','P','Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich (\'prion\') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya.','2013-10-27','NSRP'),(19741,40031,'snRNA modification','P','The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA.','2013-10-27','NSRP'),(19742,40032,'post-embryonic body morphogenesis','P','The process in which the anatomical structures of the post-embryonic soma are generated and organized.','2013-10-27','NSRP'),(19743,40033,'negative regulation of translation, ncRNA-mediated','P','Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein.','2013-10-27','NSRP'),(19744,40034,'regulation of development, heterochronic','P','Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.','2013-10-27','NSRP'),(19745,40035,'hermaphrodite genitalia development','P','The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures.','2013-10-27','NSRP'),(19746,40036,'regulation of fibroblast growth factor receptor signaling pathway','P','Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.','2013-10-27','NSRP'),(19747,40037,'negative regulation of fibroblast growth factor receptor signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.','2013-10-27','NSRP'),(19748,40038,'polar body extrusion after meiotic divisions','P','The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes.','2013-10-27','NSRP'),(19749,40039,'inductive cell migration','P','Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans.','2013-10-27','NSRP'),(19750,40040,'thermosensory behavior','P','Behavior that is dependent upon the sensation of temperature.','2013-10-27','NSRP'),(19751,42000,'translocation of peptides or proteins into host','P','The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(19752,42001,'hermaphrodite somatic sex determination','P','The determination of sex and sexual phenotypes in a hermaphroditic organism\'s soma. An example of this is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(19753,42003,'masculinization of hermaphrodite soma','P','Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(19754,42004,'feminization of hermaphrodite soma','P','Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(19755,42006,'masculinization of hermaphroditic germ-line','P','The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(19756,42007,'interleukin-18 binding','F','Interacting selectively and non-covalently with interleukin-18.','2013-10-27','NSRP'),(19757,42008,'interleukin-18 receptor activity','F','Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(19758,42009,'interleukin-15 binding','F','Interacting selectively and non-covalently with interleukin-15.','2013-10-27','NSRP'),(19759,42010,'interleukin-15 receptor activity','F','Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(19760,42011,'interleukin-16 binding','F','Interacting selectively and non-covalently with interleukin-16.','2013-10-27','NSRP'),(19761,42012,'interleukin-16 receptor activity','F','Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(19762,42013,'interleukin-19 binding','F','Interacting selectively and non-covalently with interleukin-19.','2013-10-27','NSRP'),(19763,42014,'interleukin-19 receptor activity','F','Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(19764,42015,'interleukin-20 binding','F','Interacting selectively and non-covalently with interleukin-20.','2013-10-27','NSRP'),(19765,42016,'interleukin-20 receptor activity','F','Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(19766,42017,'interleukin-22 binding','F','Interacting selectively and non-covalently with interleukin-22.','2013-10-27','NSRP'),(19767,42018,'interleukin-22 receptor activity','F','Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(19768,42019,'interleukin-23 binding','F','Interacting selectively and non-covalently with interleukin-23.','2013-10-27','NSRP'),(19769,42020,'interleukin-23 receptor activity','F','Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(19770,42021,'granulocyte macrophage colony-stimulating factor complex binding','F','Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor complex.','2013-10-27','NSRP'),(19771,42022,'interleukin-12 receptor complex','C','A protein complex that binds interleukin-12; comprises a beta1 and a beta2 subunit.','2013-10-27','NSRP'),(19772,42023,'DNA endoreduplication','P','Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.','2013-10-27','NSRP'),(19773,42025,'host cell nucleus','C','A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(19774,42026,'protein refolding','P','The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.','2013-10-27','NSRP'),(19775,42027,'cyclophilin-type peptidyl-prolyl cis-trans isomerase activity','F','OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0).','2013-10-27','NSRP'),(19776,42029,'fibrolase activity','F','OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen.','2013-10-27','NSRP'),(19777,42030,'ATPase inhibitor activity','F','Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate.','2013-10-27','NSRP'),(19778,42031,'angiotensin-converting enzyme inhibitor activity','F','OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I.','2013-10-27','NSRP'),(19779,42033,'chemokine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of chemokines, any of a subgroup of cytokines which act primarily on hemopoietic cells in acute and inflammatory processes and other immunoregulatory functions.','2013-10-27','NSRP'),(19780,42034,'peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine','P','The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester.','2013-10-27','NSRP'),(19781,42035,'regulation of cytokine biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.','2013-10-27','NSRP'),(19782,42036,'negative regulation of cytokine biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.','2013-10-27','NSRP'),(19783,42037,'peptidyl-histidine methylation, to form pros-methylhistidine','P','The methylation of peptidyl-L-histidine to form peptidyl-L-3\'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine).','2013-10-27','NSRP'),(19784,42038,'peptidyl-histidine methylation, to form tele-methylhistidine','P','The methylation of peptidyl-L-histidine to form peptidyl-L-1\'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine).','2013-10-27','NSRP'),(19785,42039,'vanadium incorporation into metallo-sulfur cluster','P','The incorporation of vanadium a metallo-sulfur cluster such as VFe(7-8)S(n).','2013-10-27','NSRP'),(19786,42040,'metal incorporation into metallo-molybdopterin complex','P','The incorporation of a metal into a metallo-molybdopterin complex.','2013-10-27','NSRP'),(19787,42042,'tungsten incorporation into tungsten-molybdopterin complex','P','The incorporation of tungsten into a tungsten-molybdopterin complex.','2013-10-27','NSRP'),(19788,42043,'neurexin family protein binding','F','Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.','2013-10-27','NSRP'),(19789,42044,'fluid transport','P','The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(19790,42045,'epithelial fluid transport','P','The directed movement of fluid across epithelia.','2013-10-27','NSRP'),(19791,42046,'W-molybdopterin cofactor metabolic process','P','The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.','2013-10-27','NSRP'),(19792,42047,'W-molybdopterin cofactor biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.','2013-10-27','NSRP'),(19793,42048,'olfactory behavior','P','The behavior of an organism in response to an odor.','2013-10-27','NSRP'),(19794,42049,'cellular acyl-CoA homeostasis','P','Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment.','2013-10-27','NSRP'),(19795,42051,'compound eye photoreceptor development','P','The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.','2013-10-27','NSRP'),(19796,42052,'rhabdomere development','P','The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.','2013-10-27','NSRP'),(19797,42053,'regulation of dopamine metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine.','2013-10-27','NSRP'),(19798,42054,'histone methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.','2013-10-27','NSRP'),(19799,42056,'chemoattractant activity','F','Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.','2013-10-27','NSRP'),(19800,42057,'transforming growth factor beta receptor anchoring activity','F','OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location.','2013-10-27','NSRP'),(19801,42058,'regulation of epidermal growth factor receptor signaling pathway','P','Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.','2013-10-27','NSRP'),(19802,42059,'negative regulation of epidermal growth factor receptor signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.','2013-10-27','NSRP'),(19803,42060,'wound healing','P','The series of events that restore integrity to a damaged tissue, following an injury.','2013-10-27','NSRP'),(19804,42062,'long-term strengthening of neuromuscular junction','P','Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse.','2013-10-27','NSRP'),(19805,42063,'gliogenesis','P','The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.','2013-10-27','NSRP'),(19806,42064,'cell adhesion receptor regulator activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(19807,42065,'glial cell growth','P','Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.','2013-10-27','NSRP'),(19808,42066,'perineurial glial growth','P','Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons.','2013-10-27','NSRP'),(19809,42067,'establishment of ommatidial planar polarity','P','The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.','2013-10-27','NSRP'),(19810,42068,'regulation of pteridine metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine.','2013-10-27','NSRP'),(19811,42069,'regulation of catecholamine metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.','2013-10-27','NSRP'),(19812,42070,'maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification','P','Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster.','2013-10-27','NSRP'),(19813,42071,'leucokinin receptor activity','F','Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity.','2013-10-27','NSRP'),(19814,42072,'cell adhesion receptor inhibitor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(19815,42073,'intraflagellar transport','P','The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.','2013-10-27','NSRP'),(19816,42074,'cell migration involved in gastrulation','P','The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).','2013-10-27','NSRP'),(19817,42075,'nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide','P','The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase.','2013-10-27','NSRP'),(19818,42076,'protein phosphate-linked glycosylation','P','The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues.','2013-10-27','NSRP'),(19819,42077,'protein phosphate-linked glycosylation via serine','P','The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues.','2013-10-27','NSRP'),(19820,42078,'germ-line stem cell division','P','The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.','2013-10-27','NSRP'),(19821,42079,'GPI/GSI anchor metabolic process','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(19822,42080,'GPI/GSI anchor biosynthetic process','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(19823,42081,'GSI anchor metabolic process','P','The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane.','2013-10-27','NSRP'),(19824,42082,'GSI anchor biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage.','2013-10-27','NSRP'),(19825,42083,'5,10-methylenetetrahydrofolate-dependent methyltransferase activity','F','Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate.','2013-10-27','NSRP'),(19826,42084,'5-methyltetrahydrofolate-dependent methyltransferase activity','F','Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate.','2013-10-27','NSRP'),(19827,42085,'5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity','F','Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate.','2013-10-27','NSRP'),(19828,42086,'5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity','F','Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin.','2013-10-27','NSRP'),(19829,42088,'T-helper 1 type immune response','P','An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.','2013-10-27','NSRP'),(19830,42089,'cytokine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.','2013-10-27','NSRP'),(19831,42090,'interleukin-12 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-12.','2013-10-27','NSRP'),(19832,42091,'interleukin-10 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-10.','2013-10-27','NSRP'),(19833,42092,'type 2 immune response','P','An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.','2013-10-27','NSRP'),(19834,42093,'T-helper cell differentiation','P','The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.','2013-10-27','NSRP'),(19835,42094,'interleukin-2 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-2.','2013-10-27','NSRP'),(19836,42095,'interferon-gamma biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interferon-gamma.','2013-10-27','NSRP'),(19837,42096,'alpha-beta T cell receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(19838,42097,'interleukin-4 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-4.','2013-10-27','NSRP'),(19839,42098,'T cell proliferation','P','The expansion of a T cell population by cell division. Follows T cell activation.','2013-10-27','NSRP'),(19840,42099,'gamma-delta T cell receptor activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(19841,42100,'B cell proliferation','P','The expansion of a B cell population by cell division. Follows B cell activation.','2013-10-27','NSRP'),(19842,42101,'T cell receptor complex','C','A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.','2013-10-27','NSRP'),(19843,42102,'positive regulation of T cell proliferation','P','Any process that activates or increases the rate or extent of T cell proliferation.','2013-10-27','NSRP'),(19844,42103,'positive regulation of T cell homeostatic proliferation','P','Any process that activates or increases the rate or extent of resting T cell proliferation.','2013-10-27','NSRP'),(19845,42104,'positive regulation of activated T cell proliferation','P','Any process that activates or increases the rate or extent of activated T cell proliferation.','2013-10-27','NSRP'),(19846,42105,'alpha-beta T cell receptor complex','C','A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein.','2013-10-27','NSRP'),(19847,42106,'gamma-delta T cell receptor complex','C','A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein.','2013-10-27','NSRP'),(19848,42107,'cytokine metabolic process','P','The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.','2013-10-27','NSRP'),(19849,42108,'positive regulation of cytokine biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines.','2013-10-27','NSRP'),(19850,42109,'lymphotoxin A biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A.','2013-10-27','NSRP'),(19851,42110,'T cell activation','P','The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.','2013-10-27','NSRP'),(19852,42113,'B cell activation','P','The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.','2013-10-27','NSRP'),(19853,42116,'macrophage activation','P','A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(19854,42117,'monocyte activation','P','The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(19855,42118,'endothelial cell activation','P','The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(19856,42119,'neutrophil activation','P','The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.','2013-10-27','NSRP'),(19857,42120,'alginic acid metabolic process','P','The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).','2013-10-27','NSRP'),(19858,42121,'alginic acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).','2013-10-27','NSRP'),(19859,42122,'alginic acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).','2013-10-27','NSRP'),(19860,42123,'glucanosyltransferase activity','F','Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation.','2013-10-27','NSRP'),(19861,42124,'1,3-beta-glucanosyltransferase activity','F','Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation.','2013-10-27','NSRP'),(19862,42125,'protein galactosylation','P','The addition of a galactose molecule to a protein amino acid.','2013-10-27','NSRP'),(19863,42126,'nitrate metabolic process','P','The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid.','2013-10-27','NSRP'),(19864,42127,'regulation of cell proliferation','P','Any process that modulates the frequency, rate or extent of cell proliferation.','2013-10-27','NSRP'),(19865,42128,'nitrate assimilation','P','The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.','2013-10-27','NSRP'),(19866,42129,'regulation of T cell proliferation','P','Any process that modulates the frequency, rate or extent of T cell proliferation.','2013-10-27','NSRP'),(19867,42130,'negative regulation of T cell proliferation','P','Any process that stops, prevents or reduces the rate or extent of T cell proliferation.','2013-10-27','NSRP'),(19868,42131,'thiamine phosphate phosphatase activity','F','Catalysis of the hydrolysis of thiamine phosphate.','2013-10-27','NSRP'),(19869,42132,'fructose 1,6-bisphosphate 1-phosphatase activity','F','Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.','2013-10-27','NSRP'),(19870,42133,'neurotransmitter metabolic process','P','The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.','2013-10-27','NSRP'),(19871,42134,'rRNA primary transcript binding','F','Interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript.','2013-10-27','NSRP'),(19872,42135,'neurotransmitter catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.','2013-10-27','NSRP'),(19873,42136,'neurotransmitter biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.','2013-10-27','NSRP'),(19874,42137,'sequestering of neurotransmitter','P','The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system.','2013-10-27','NSRP'),(19875,42138,'meiotic DNA double-strand break formation','P','The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.','2013-10-27','NSRP'),(19876,42139,'early meiotic recombination nodule assembly','P','During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene.','2013-10-27','NSRP'),(19877,42140,'late meiotic recombination nodule assembly','P','During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over.','2013-10-27','NSRP'),(19878,42141,'mating pheromone exporter','F','OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating.','2013-10-27','NSRP'),(19879,42142,'heavy metal chelation','P','OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein.','2013-10-27','NSRP'),(19880,42144,'vacuole fusion, non-autophagic','P','The fusion of two vacuole membranes to form a single vacuole.','2013-10-27','NSRP'),(19881,42147,'retrograde transport, endosome to Golgi','P','The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.','2013-10-27','NSRP'),(19882,42148,'strand invasion','P','The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.','2013-10-27','NSRP'),(19883,42149,'cellular response to glucose starvation','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.','2013-10-27','NSRP'),(19884,42150,'plasmid recombination','P','A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules.','2013-10-27','NSRP'),(19885,42151,'nematocyst','C','An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus.','2013-10-27','NSRP'),(19886,42152,'RNA-mediated DNA recombination','P','The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele.','2013-10-27','NSRP'),(19887,42153,'RPTP-like protein binding','F','OBSOLETE. Interacting selectively and non-covalently with proteins with similar structure/function to receptor protein tyrosine phosphatases.','2013-10-27','NSRP'),(19888,42156,'zinc-mediated transcriptional activator activity','F','OBSOLETE. Initiates or upregulates transcription in the presence of zinc.','2013-10-27','NSRP'),(19889,42157,'lipoprotein metabolic process','P','The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.','2013-10-27','NSRP'),(19890,42158,'lipoprotein biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.','2013-10-27','NSRP'),(19891,42159,'lipoprotein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.','2013-10-27','NSRP'),(19892,42160,'lipoprotein modification','P','The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.','2013-10-27','NSRP'),(19893,42161,'lipoprotein oxidation','P','The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group.','2013-10-27','NSRP'),(19894,42162,'telomeric DNA binding','F','Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.','2013-10-27','NSRP'),(19895,42163,'interleukin-12 beta subunit binding','F','Interacting selectively and non-covalently with the beta subunit of interleukin-12.','2013-10-27','NSRP'),(19896,42164,'interleukin-12 alpha subunit binding','F','Interacting selectively and non-covalently with the alpha subunit of interleukin-12.','2013-10-27','NSRP'),(19897,42165,'neurotransmitter binding','F','Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.','2013-10-27','NSRP'),(19898,42166,'acetylcholine binding','F','Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.','2013-10-27','NSRP'),(19899,42167,'heme catabolic process','P','The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.','2013-10-27','NSRP'),(19900,42168,'heme metabolic process','P','The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.','2013-10-27','NSRP'),(19901,42169,'SH2 domain binding','F','Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.','2013-10-27','NSRP'),(19902,42170,'plastid membrane','C','Either of the lipid bilayers that surround a plastid and form the plastid envelope.','2013-10-27','NSRP'),(19903,42171,'lysophosphatidic acid acyltransferase activity','F','Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid.','2013-10-27','NSRP'),(19904,42173,'regulation of sporulation resulting in formation of a cellular spore','P','Any process that modulates the frequency, rate or extent of spore formation.','2013-10-27','NSRP'),(19905,42174,'negative regulation of sporulation resulting in formation of a cellular spore','P','Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation.','2013-10-27','NSRP'),(19906,42175,'nuclear outer membrane-endoplasmic reticulum membrane network','C','The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.','2013-10-27','NSRP'),(19907,42176,'regulation of protein catabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.','2013-10-27','NSRP'),(19908,42177,'negative regulation of protein catabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.','2013-10-27','NSRP'),(19909,42178,'xenobiotic catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.','2013-10-27','NSRP'),(19910,42179,'nicotine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine.','2013-10-27','NSRP'),(19911,42180,'cellular ketone metabolic process','P','The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.','2013-10-27','NSRP'),(19912,42181,'ketone biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.','2013-10-27','NSRP'),(19913,42182,'ketone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.','2013-10-27','NSRP'),(19914,42183,'formate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.','2013-10-27','NSRP'),(19915,42184,'xylene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene.','2013-10-27','NSRP'),(19916,42185,'m-xylene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon.','2013-10-27','NSRP'),(19917,42186,'o-xylene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon.','2013-10-27','NSRP'),(19918,42187,'p-xylene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon.','2013-10-27','NSRP'),(19919,42188,'1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide.','2013-10-27','NSRP'),(19920,42189,'vanillin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods.','2013-10-27','NSRP'),(19921,42190,'vanillin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods.','2013-10-27','NSRP'),(19922,42191,'methylmercury metabolic process','P','The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species.','2013-10-27','NSRP'),(19923,42192,'methylmercury biosynthetic process','P','The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal.','2013-10-27','NSRP'),(19924,42193,'methylmercury catabolic process','P','The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal.','2013-10-27','NSRP'),(19925,42194,'quinate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid.','2013-10-27','NSRP'),(19926,42195,'aerobic gallate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen.','2013-10-27','NSRP'),(19927,42196,'chlorinated hydrocarbon metabolic process','P','The chemical reactions and pathways involving chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it.','2013-10-27','NSRP'),(19928,42197,'halogenated hydrocarbon metabolic process','P','The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine.','2013-10-27','NSRP'),(19929,42198,'nylon metabolic process','P','The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids.','2013-10-27','NSRP'),(19930,42199,'cyanuric acid metabolic process','P','The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives.','2013-10-27','NSRP'),(19931,42200,'cyanuric acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides.','2013-10-27','NSRP'),(19932,42201,'N-cyclopropylmelamine metabolic process','P','The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide.','2013-10-27','NSRP'),(19933,42202,'N-cyclopropylmelamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide.','2013-10-27','NSRP'),(19934,42203,'toluene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.','2013-10-27','NSRP'),(19935,42204,'s-triazine compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms.','2013-10-27','NSRP'),(19936,42205,'chlorinated hydrocarbon catabolic process','P','The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it.','2013-10-27','NSRP'),(19937,42206,'halogenated hydrocarbon catabolic process','P','The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it.','2013-10-27','NSRP'),(19938,42207,'styrene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene.','2013-10-27','NSRP'),(19939,42208,'propylene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining.','2013-10-27','NSRP'),(19940,42209,'orcinol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants.','2013-10-27','NSRP'),(19941,42210,'octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol','P','The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter.','2013-10-27','NSRP'),(19942,42211,'dimethylsilanediol catabolic process','P','The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products.','2013-10-27','NSRP'),(19943,42212,'cresol metabolic process','P','The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote.','2013-10-27','NSRP'),(19944,42213,'m-cresol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol.','2013-10-27','NSRP'),(19945,42214,'terpene metabolic process','P','The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups.','2013-10-27','NSRP'),(19946,42215,'anaerobic phenol-containing compound metabolic process','P','The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen.','2013-10-27','NSRP'),(19947,42216,'phenanthrene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon.','2013-10-27','NSRP'),(19948,42217,'1-aminocyclopropane-1-carboxylate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.','2013-10-27','NSRP'),(19949,42218,'1-aminocyclopropane-1-carboxylate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.','2013-10-27','NSRP'),(19950,42219,'cellular modified amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.','2013-10-27','NSRP'),(19951,42220,'response to cocaine','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.','2013-10-27','NSRP'),(19952,42221,'response to chemical stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.','2013-10-27','NSRP'),(19953,42222,'interleukin-1 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen.','2013-10-27','NSRP'),(19954,42223,'interleukin-3 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-3.','2013-10-27','NSRP'),(19955,42225,'interleukin-5 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-5.','2013-10-27','NSRP'),(19956,42226,'interleukin-6 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-6.','2013-10-27','NSRP'),(19957,42227,'interleukin-7 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-7.','2013-10-27','NSRP'),(19958,42228,'interleukin-8 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-8.','2013-10-27','NSRP'),(19959,42229,'interleukin-9 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-9.','2013-10-27','NSRP'),(19960,42230,'interleukin-11 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-11.','2013-10-27','NSRP'),(19961,42231,'interleukin-13 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-13.','2013-10-27','NSRP'),(19962,42232,'interleukin-14 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-14.','2013-10-27','NSRP'),(19963,42233,'interleukin-15 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-15.','2013-10-27','NSRP'),(19964,42234,'interleukin-16 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-16.','2013-10-27','NSRP'),(19965,42235,'interleukin-17 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines.','2013-10-27','NSRP'),(19966,42236,'interleukin-19 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-19.','2013-10-27','NSRP'),(19967,42237,'interleukin-20 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-20.','2013-10-27','NSRP'),(19968,42238,'interleukin-21 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-21.','2013-10-27','NSRP'),(19969,42239,'interleukin-22 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-22.','2013-10-27','NSRP'),(19970,42240,'interleukin-23 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-23.','2013-10-27','NSRP'),(19971,42241,'interleukin-18 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of interleukin-18.','2013-10-27','NSRP'),(19972,42242,'cobyrinic acid a,c-diamide synthase activity','F','Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide.','2013-10-27','NSRP'),(19973,42243,'asexual spore wall assembly','P','The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from a product of mitosis. Examples of this process are found in Bacterial and Fungal species.','2013-10-27','NSRP'),(19974,42244,'spore wall assembly','P','The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore.','2013-10-27','NSRP'),(19975,42245,'RNA repair','P','Any process that results in the repair of damaged RNA.','2013-10-27','NSRP'),(19976,42246,'tissue regeneration','P','The regrowth of lost or destroyed tissues.','2013-10-27','NSRP'),(19977,42247,'establishment of planar polarity of follicular epithelium','P','Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates.','2013-10-27','NSRP'),(19978,42248,'maintenance of polarity of follicular epithelium','P','The maintenance of an established polarized follicular epithelial sheet.','2013-10-27','NSRP'),(19979,42249,'establishment of planar polarity of embryonic epithelium','P','Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates.','2013-10-27','NSRP'),(19980,42250,'maintenance of polarity of embryonic epithelium','P','The maintenance of an established polarized embryonic epithelial sheet.','2013-10-27','NSRP'),(19981,42251,'maintenance of polarity of larval imaginal disc epithelium','P','The maintenance of an established polarized larval imaginal disc epithelium.','2013-10-27','NSRP'),(19982,42252,'establishment of planar polarity of larval imaginal disc epithelium','P','Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates.','2013-10-27','NSRP'),(19983,42253,'granulocyte macrophage colony-stimulating factor biosynthetic process','P','The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages.','2013-10-27','NSRP'),(19984,42254,'ribosome biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.','2013-10-27','NSRP'),(19985,42255,'ribosome assembly','P','The aggregation, arrangement and bonding together of the mature ribosome and of its subunits.','2013-10-27','NSRP'),(19986,42256,'mature ribosome assembly','P','The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.','2013-10-27','NSRP'),(19987,42258,'molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide','P','The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide.','2013-10-27','NSRP'),(19988,42259,'peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine','P','The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12.','2013-10-27','NSRP'),(19989,42262,'DNA protection','P','Any process in which DNA is protected from damage by, for example, oxidative stress.','2013-10-27','NSRP'),(19990,42263,'neuropeptide F receptor activity','F','Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa.','2013-10-27','NSRP'),(19991,42264,'peptidyl-aspartic acid hydroxylation','P','The hydroxylation of peptidyl-aspartic acid to form peptidyl-hydroxyaspartic acid.','2013-10-27','NSRP'),(19992,42265,'peptidyl-asparagine hydroxylation','P','The hydroxylation of peptidyl-asparagine to form peptidyl-hydroxyasparagine.','2013-10-27','NSRP'),(19993,42267,'natural killer cell mediated cytotoxicity','P','The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.','2013-10-27','NSRP'),(19994,42268,'regulation of cytolysis','P','Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm.','2013-10-27','NSRP'),(19995,42269,'regulation of natural killer cell mediated cytotoxicity','P','Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.','2013-10-27','NSRP'),(19996,42270,'protection from natural killer cell mediated cytotoxicity','P','The process of protecting a cell from natural killer cell mediated cytotoxicity.','2013-10-27','NSRP'),(19997,42271,'susceptibility to natural killer cell mediated cytotoxicity','P','The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.','2013-10-27','NSRP'),(19998,42272,'nuclear RNA export factor complex','C','A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm.','2013-10-27','NSRP'),(19999,42273,'ribosomal large subunit biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.','2013-10-27','NSRP'),(20000,42274,'ribosomal small subunit biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.','2013-10-27','NSRP'),(20001,42275,'error-free postreplication DNA repair','P','The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions and but does not increase the endogenous mutation rate.','2013-10-27','NSRP'),(20002,42276,'error-prone translesion synthesis','P','The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.','2013-10-27','NSRP'),(20003,42277,'peptide binding','F','Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds.','2013-10-27','NSRP'),(20004,42278,'purine nucleoside metabolic process','P','The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).','2013-10-27','NSRP'),(20005,42279,'nitrite reductase (cytochrome, ammonia-forming) activity','F','Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+.','2013-10-27','NSRP'),(20006,42280,'cell surface antigen activity, host-interacting','F','OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition.','2013-10-27','NSRP'),(20007,42281,'dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity','F','Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.','2013-10-27','NSRP'),(20008,42282,'hydroxymethylglutaryl-CoA reductase activity','F','Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH.','2013-10-27','NSRP'),(20009,42283,'dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity','F','Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.','2013-10-27','NSRP'),(20010,42284,'sphingolipid delta-4 desaturase activity','F','Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid.','2013-10-27','NSRP'),(20011,42285,'xylosyltransferase activity','F','Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid.','2013-10-27','NSRP'),(20012,42286,'glutamate-1-semialdehyde 2,1-aminomutase activity','F','Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.','2013-10-27','NSRP'),(20013,42287,'MHC protein binding','F','Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.','2013-10-27','NSRP'),(20014,42288,'MHC class I protein binding','F','Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.','2013-10-27','NSRP'),(20015,42289,'MHC class II protein binding','F','Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.','2013-10-27','NSRP'),(20016,42290,'URM1 hydrolase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(20017,42291,'Hub1 hydrolase activity','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(20018,42292,'URM1 activating enzyme activity','F','Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond.','2013-10-27','NSRP'),(20019,42293,'Hub1 activating enzyme activity','F','Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond.','2013-10-27','NSRP'),(20020,42294,'URM1 conjugating enzyme activity','F','Catalysis of the covalent attachment of the ubiquitin-like protein URM1 to other proteins or other substrate molecules.','2013-10-27','NSRP'),(20021,42296,'ISG15 ligase activity','F','Catalysis of the covalent attachment of the ubiquitin-like protein ISG15 to other proteins.','2013-10-27','NSRP'),(20022,42297,'vocal learning','P','A behavioral process whose outcome is a relatively long-lasting adaptive behavioral change whereby an organism modifies innate vocalizations to imitate or create new sounds.','2013-10-27','NSRP'),(20023,42299,'lupeol synthase activity','F','Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol.','2013-10-27','NSRP'),(20024,42300,'beta-amyrin synthase activity','F','Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin.','2013-10-27','NSRP'),(20025,42301,'phosphate ion binding','F','Interacting selectively and non-covalently with phosphate.','2013-10-27','NSRP'),(20026,42302,'structural constituent of cuticle','F','The action of a molecule that contributes to the structural integrity of a cuticle.','2013-10-27','NSRP'),(20027,42303,'molting cycle','P','The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc.','2013-10-27','NSRP'),(20028,42304,'regulation of fatty acid biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.','2013-10-27','NSRP'),(20029,42305,'specification of segmental identity, mandibular segment','P','The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.','2013-10-27','NSRP'),(20030,42306,'regulation of protein import into nucleus','P','Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus.','2013-10-27','NSRP'),(20031,42307,'positive regulation of protein import into nucleus','P','Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.','2013-10-27','NSRP'),(20032,42308,'negative regulation of protein import into nucleus','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus.','2013-10-27','NSRP'),(20033,42309,'homoiothermy','P','Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment.','2013-10-27','NSRP'),(20034,42310,'vasoconstriction','P','A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure.','2013-10-27','NSRP'),(20035,42311,'vasodilation','P','An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure.','2013-10-27','NSRP'),(20036,42312,'regulation of vasodilation','P','Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels.','2013-10-27','NSRP'),(20037,42313,'protein kinase C deactivation','P','Any process resulting in the inhibition or termination of the activity of protein kinase C.','2013-10-27','NSRP'),(20038,42314,'bacteriochlorophyll binding','F','Interacting selectively and non-covalently with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants.','2013-10-27','NSRP'),(20039,42315,'cytosol nonspecific dipeptidase activity','F','OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids.','2013-10-27','NSRP'),(20040,42316,'penicillin metabolic process','P','The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus.','2013-10-27','NSRP'),(20041,42317,'penicillin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.','2013-10-27','NSRP'),(20042,42318,'penicillin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system.','2013-10-27','NSRP'),(20043,42320,'regulation of circadian sleep/wake cycle, REM sleep','P','Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep.','2013-10-27','NSRP'),(20044,42321,'negative regulation of circadian sleep/wake cycle, sleep','P','Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals.','2013-10-27','NSRP'),(20045,42322,'negative regulation of circadian sleep/wake cycle, REM sleep','P','Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep.','2013-10-27','NSRP'),(20046,42323,'negative regulation of circadian sleep/wake cycle, non-REM sleep','P','Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep.','2013-10-27','NSRP'),(20047,42324,'hypocretin receptor binding','F','Interacting selectively and non-covalently with the hypocretin receptor.','2013-10-27','NSRP'),(20048,42325,'regulation of phosphorylation','P','Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.','2013-10-27','NSRP'),(20049,42326,'negative regulation of phosphorylation','P','Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.','2013-10-27','NSRP'),(20050,42327,'positive regulation of phosphorylation','P','Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.','2013-10-27','NSRP'),(20051,42328,'heparan sulfate N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate.','2013-10-27','NSRP'),(20052,42329,'structural constituent of collagen and cuticulin-based cuticle','F','The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(20053,42330,'taxis','P','The directed movement of a motile cell or organism in response to an external stimulus.','2013-10-27','NSRP'),(20054,42331,'phototaxis','P','The directed movement of a motile cell or organism in response to light.','2013-10-27','NSRP'),(20055,42332,'gravitaxis','P','The directed movement of a motile cell or organism in response to gravity.','2013-10-27','NSRP'),(20056,42333,'chemotaxis to oxidizable substrate','P','The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose.','2013-10-27','NSRP'),(20057,42334,'taxis to electron acceptor','P','The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate.','2013-10-27','NSRP'),(20058,42335,'cuticle development','P','The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.','2013-10-27','NSRP'),(20059,42336,'cuticle development involved in protein-based cuticle molting cycle','P','OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species.','2013-10-27','NSRP'),(20060,42337,'cuticle development involved in chitin-based cuticle molting cycle','P','The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(20061,42338,'cuticle development involved in collagen and cuticulin-based cuticle molting cycle','P','Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(20062,42339,'keratan sulfate metabolic process','P','The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.','2013-10-27','NSRP'),(20063,42340,'keratan sulfate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues.','2013-10-27','NSRP'),(20064,42341,'cyanogenic glycoside metabolic process','P','The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits.','2013-10-27','NSRP'),(20065,42342,'cyanogenic glycoside catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits.','2013-10-27','NSRP'),(20066,42343,'indole glucosinolate metabolic process','P','The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan.','2013-10-27','NSRP'),(20067,42344,'indole glucosinolate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan.','2013-10-27','NSRP'),(20068,42345,'regulation of NF-kappaB import into nucleus','P','Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.','2013-10-27','NSRP'),(20069,42346,'positive regulation of NF-kappaB import into nucleus','P','Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.','2013-10-27','NSRP'),(20070,42347,'negative regulation of NF-kappaB import into nucleus','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.','2013-10-27','NSRP'),(20071,42348,'NF-kappaB import into nucleus','P','The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane.','2013-10-27','NSRP'),(20072,42349,'guiding stereospecific synthesis activity','F','The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis.','2013-10-27','NSRP'),(20073,42350,'GDP-L-fucose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate.','2013-10-27','NSRP'),(20074,42351,'\'de novo\' GDP-L-fucose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271).','2013-10-27','NSRP'),(20075,42352,'GDP-L-fucose salvage','P','The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30).','2013-10-27','NSRP'),(20076,42353,'fucose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose).','2013-10-27','NSRP'),(20077,42354,'L-fucose metabolic process','P','The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants.','2013-10-27','NSRP'),(20078,42355,'L-fucose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose).','2013-10-27','NSRP'),(20079,42356,'GDP-4-dehydro-D-rhamnose reductase activity','F','Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed.','2013-10-27','NSRP'),(20080,42357,'thiamine diphosphate metabolic process','P','The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.','2013-10-27','NSRP'),(20081,42358,'thiamine diphosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.','2013-10-27','NSRP'),(20082,42359,'vitamin D metabolic process','P','The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).','2013-10-27','NSRP'),(20083,42360,'vitamin E metabolic process','P','The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.','2013-10-27','NSRP'),(20084,42361,'menaquinone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2.','2013-10-27','NSRP'),(20085,42362,'fat-soluble vitamin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.','2013-10-27','NSRP'),(20086,42363,'fat-soluble vitamin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water.','2013-10-27','NSRP'),(20087,42364,'water-soluble vitamin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water.','2013-10-27','NSRP'),(20088,42365,'water-soluble vitamin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water.','2013-10-27','NSRP'),(20089,42366,'cobalamin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.','2013-10-27','NSRP'),(20090,42367,'biotin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.','2013-10-27','NSRP'),(20091,42368,'vitamin D biosynthetic process','P','The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).','2013-10-27','NSRP'),(20092,42369,'vitamin D catabolic process','P','The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3).','2013-10-27','NSRP'),(20093,42370,'thiamine diphosphate dephosphorylation','P','The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.','2013-10-27','NSRP'),(20094,42371,'vitamin K biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals.','2013-10-27','NSRP'),(20095,42372,'phylloquinone biosynthetic process','P','The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants.','2013-10-27','NSRP'),(20096,42373,'vitamin K metabolic process','P','The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule.','2013-10-27','NSRP'),(20097,42374,'phylloquinone metabolic process','P','The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1.','2013-10-27','NSRP'),(20098,42375,'quinone cofactor metabolic process','P','The chemical reactions and pathways involving quinone cofactors.','2013-10-13','NSRP'),(20099,42376,'phylloquinone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants.','2013-10-27','NSRP'),(20100,42377,'vitamin K catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals.','2013-10-27','NSRP'),(20101,42378,'quinone cofactor catabolic process','P','The chemical reactions and pathways resulting in the breakdown of quinone cofactors.','2013-10-13','NSRP'),(20102,42379,'chemokine receptor binding','F','Interacting selectively and non-covalently with any chemokine receptor.','2013-10-27','NSRP'),(20103,42380,'hydroxymethylbutenyl pyrophosphate reductase activity','F','Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate.','2013-10-27','NSRP'),(20104,42381,'hemolymph coagulation','P','Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response.','2013-10-27','NSRP'),(20105,42382,'paraspeckles','C','Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei.','2013-10-27','NSRP'),(20106,42383,'sarcolemma','C','The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.','2013-10-27','NSRP'),(20107,42384,'cilium assembly','P','The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.','2013-10-27','NSRP'),(20108,42385,'myosin III complex','C','A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain.','2013-10-27','NSRP'),(20109,42386,'hemocyte differentiation','P','The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen.','2013-10-27','NSRP'),(20110,42387,'plasmatocyte differentiation','P','The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response.','2013-10-27','NSRP'),(20111,42388,'gibberellic acid mediated signaling pathway, G-alpha-dependent','P','A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors.','2013-10-27','NSRP'),(20112,42389,'omega-3 fatty acid desaturase activity','F','Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain.','2013-10-27','NSRP'),(20113,42390,'gibberellic acid mediated signaling pathway, G-alpha-independent','P','A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors.','2013-10-27','NSRP'),(20114,42391,'regulation of membrane potential','P','Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.','2013-10-27','NSRP'),(20115,42392,'sphingosine-1-phosphate phosphatase activity','F','Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate.','2013-10-27','NSRP'),(20116,42393,'histone binding','F','Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.','2013-10-27','NSRP'),(20117,42394,'ecdysis, protein-based cuticle','P','OBSOLETE. The shedding of the old protein-based cuticular fragments during the molting cycle. Examples of this process are found in invertebrates.','2013-10-27','NSRP'),(20118,42395,'ecdysis, collagen and cuticulin-based cuticle','P','The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates.','2013-10-27','NSRP'),(20119,42396,'phosphagen biosynthetic process','P','The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction.','2013-10-27','NSRP'),(20120,42397,'phosphagen catabolic process','P','The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction.','2013-10-27','NSRP'),(20121,42398,'cellular modified amino acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents.','2013-10-27','NSRP'),(20122,42399,'ectoine metabolic process','P','The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria.','2013-10-27','NSRP'),(20123,42400,'ectoine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria.','2013-10-27','NSRP'),(20124,42401,'cellular biogenic amine biosynthetic process','P','The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.','2013-10-27','NSRP'),(20125,42402,'cellular biogenic amine catabolic process','P','The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.','2013-10-27','NSRP'),(20126,42403,'thyroid hormone metabolic process','P','The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.','2013-10-27','NSRP'),(20127,42404,'thyroid hormone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine.','2013-10-27','NSRP'),(20128,42405,'nuclear inclusion body','C','An intranuclear focus at which aggregated proteins have been sequestered.','2013-10-27','NSRP'),(20129,42406,'extrinsic to endoplasmic reticulum membrane','C','Loosely bound to one surface of the endoplasmic reticulum membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(20130,42407,'cristae formation','P','The assembly of cristae, the inwards folds of the inner mitochondrial membrane.','2013-10-27','NSRP'),(20131,42408,'myrcene/(E)-beta-ocimene synthase activity','F','OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes.','2013-10-27','NSRP'),(20132,42409,'caffeoyl-CoA O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA.','2013-10-27','NSRP'),(20133,42410,'6-carboxyhexanoate-CoA ligase activity','F','Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H(+) + pimelyl-CoA.','2013-10-27','NSRP'),(20134,42412,'taurine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats.','2013-10-27','NSRP'),(20135,42413,'carnitine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.','2013-10-27','NSRP'),(20136,42414,'epinephrine metabolic process','P','The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.','2013-10-27','NSRP'),(20137,42415,'norepinephrine metabolic process','P','The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.','2013-10-27','NSRP'),(20138,42416,'dopamine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.','2013-10-27','NSRP'),(20139,42417,'dopamine metabolic process','P','The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.','2013-10-27','NSRP'),(20140,42418,'epinephrine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.','2013-10-27','NSRP'),(20141,42419,'epinephrine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.','2013-10-27','NSRP'),(20142,42420,'dopamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.','2013-10-27','NSRP'),(20143,42421,'norepinephrine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.','2013-10-27','NSRP'),(20144,42422,'norepinephrine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine.','2013-10-27','NSRP'),(20145,42423,'catecholamine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.','2013-10-27','NSRP'),(20146,42424,'catecholamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine.','2013-10-27','NSRP'),(20147,42425,'choline biosynthetic process','P','The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.','2013-10-27','NSRP'),(20148,42426,'choline catabolic process','P','The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.','2013-10-27','NSRP'),(20149,42427,'serotonin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.','2013-10-27','NSRP'),(20150,42428,'serotonin metabolic process','P','The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.','2013-10-27','NSRP'),(20151,42429,'serotonin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties.','2013-10-27','NSRP'),(20152,42430,'indole-containing compound metabolic process','P','The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton.','2013-10-27','NSRP'),(20153,42431,'indole metabolic process','P','The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).','2013-10-27','NSRP'),(20154,42432,'indole biosynthetic process','P','The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).','2013-10-27','NSRP'),(20155,42433,'indole catabolic process','P','The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan).','2013-10-27','NSRP'),(20156,42435,'indole-containing compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton.','2013-10-27','NSRP'),(20157,42436,'indole-containing compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton.','2013-10-27','NSRP'),(20158,42437,'indoleacetic acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants.','2013-10-27','NSRP'),(20159,42438,'melanin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom.','2013-10-27','NSRP'),(20160,42439,'ethanolamine-containing compound metabolic process','P','The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it.','2013-10-27','NSRP'),(20161,42440,'pigment metabolic process','P','The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin.','2013-10-27','NSRP'),(20162,42441,'eye pigment metabolic process','P','The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye.','2013-10-27','NSRP'),(20163,42442,'melatonin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine).','2013-10-27','NSRP'),(20164,42443,'phenylethylamine metabolic process','P','The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds.','2013-10-27','NSRP'),(20165,42444,'phenylethylamine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds.','2013-10-27','NSRP'),(20166,42445,'hormone metabolic process','P','The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.','2013-10-27','NSRP'),(20167,42446,'hormone biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.','2013-10-27','NSRP'),(20168,42447,'hormone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.','2013-10-27','NSRP'),(20169,42448,'progesterone metabolic process','P','The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.','2013-10-27','NSRP'),(20170,42450,'arginine biosynthetic process via ornithine','P','The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.','2013-10-27','NSRP'),(20171,42451,'purine nucleoside biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside).','2013-10-27','NSRP'),(20172,42452,'deoxyguanosine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose.','2013-10-27','NSRP'),(20173,42453,'deoxyguanosine metabolic process','P','The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose.','2013-10-27','NSRP'),(20174,42454,'ribonucleoside catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.','2013-10-27','NSRP'),(20175,42455,'ribonucleoside biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.','2013-10-27','NSRP'),(20176,42457,'ethylene catabolic process','P','The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.','2013-10-27','NSRP'),(20177,42458,'nopaline catabolic process to proline','P','The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline.','2013-10-27','NSRP'),(20178,42459,'octopine catabolic process to proline','P','The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline.','2013-10-27','NSRP'),(20179,42461,'photoreceptor cell development','P','Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light.','2013-10-27','NSRP'),(20180,42462,'eye photoreceptor cell development','P','Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve.','2013-10-27','NSRP'),(20181,42463,'ocellus photoreceptor cell development','P','Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus.','2013-10-27','NSRP'),(20182,42464,'dosage compensation by hypoactivation of X chromosome','P','Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(20183,42465,'kinesis','P','The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus.','2013-10-27','NSRP'),(20184,42466,'chemokinesis','P','A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis).','2013-10-27','NSRP'),(20185,42467,'orthokinesis','P','The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased.','2013-10-27','NSRP'),(20186,42468,'klinokinesis','P','The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered.','2013-10-27','NSRP'),(20187,42469,'versicolorin reductase activity','F','Catalysis of the reduction of versicolorin A to sterigmatocystin.','2013-10-27','NSRP'),(20188,42470,'melanosome','C','A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.','2013-10-27','NSRP'),(20189,42471,'ear morphogenesis','P','The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals.','2013-10-27','NSRP'),(20190,42472,'inner ear morphogenesis','P','The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.','2013-10-27','NSRP'),(20191,42473,'outer ear morphogenesis','P','The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull.','2013-10-27','NSRP'),(20192,42474,'middle ear morphogenesis','P','The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window).','2013-10-27','NSRP'),(20193,42475,'odontogenesis of dentin-containing tooth','P','The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.','2013-10-27','NSRP'),(20194,42476,'odontogenesis','P','The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.','2013-10-27','NSRP'),(20195,42478,'regulation of eye photoreceptor cell development','P','Any process that modulates the frequency, rate or extent of eye photoreceptor development.','2013-10-27','NSRP'),(20196,42479,'positive regulation of eye photoreceptor cell development','P','Any process that activates or increases the frequency, rate or extent of eye photoreceptor development.','2013-10-27','NSRP'),(20197,42480,'negative regulation of eye photoreceptor cell development','P','Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development.','2013-10-27','NSRP'),(20198,42481,'regulation of odontogenesis','P','Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth.','2013-10-27','NSRP'),(20199,42482,'positive regulation of odontogenesis','P','Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth.','2013-10-27','NSRP'),(20200,42483,'negative regulation of odontogenesis','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth.','2013-10-27','NSRP'),(20201,42487,'regulation of odontogenesis of dentin-containing tooth','P','Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.','2013-10-27','NSRP'),(20202,42488,'positive regulation of odontogenesis of dentin-containing tooth','P','Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.','2013-10-27','NSRP'),(20203,42489,'negative regulation of odontogenesis of dentin-containing tooth','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx.','2013-10-27','NSRP'),(20204,42490,'mechanoreceptor differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system.','2013-10-27','NSRP'),(20205,42491,'auditory receptor cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell.','2013-10-27','NSRP'),(20206,42492,'gamma-delta T cell differentiation','P','The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex.','2013-10-27','NSRP'),(20207,42493,'response to drug','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.','2013-10-27','NSRP'),(20208,42494,'detection of bacterial lipoprotein','P','The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs).','2013-10-27','NSRP'),(20209,42495,'detection of triacyl bacterial lipopeptide','P','The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups.','2013-10-27','NSRP'),(20210,42496,'detection of diacyl bacterial lipopeptide','P','The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups.','2013-10-27','NSRP'),(20211,42497,'triacyl lipopeptide binding','F','Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups.','2013-10-27','NSRP'),(20212,42498,'diacyl lipopeptide binding','F','Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of two acyl groups.','2013-10-27','NSRP'),(20213,42499,'signal peptide peptidase activity','F','OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein.','2013-10-27','NSRP'),(20214,42500,'aspartic endopeptidase activity, intramembrane cleaving','F','Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within the plasma membrane.','2013-10-27','NSRP'),(20215,42501,'serine phosphorylation of STAT protein','P','The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.','2013-10-27','NSRP'),(20216,42502,'tyrosine phosphorylation of Stat2 protein','P','The process of introducing a phosphate group to a tyrosine residue of a Stat2 protein.','2013-10-27','NSRP'),(20217,42503,'tyrosine phosphorylation of Stat3 protein','P','The process of introducing a phosphate group to a tyrosine residue of a Stat3 protein.','2013-10-27','NSRP'),(20218,42504,'tyrosine phosphorylation of Stat4 protein','P','The process of introducing a phosphate group to a tyrosine residue of a Stat4 protein.','2013-10-27','NSRP'),(20219,42505,'tyrosine phosphorylation of Stat6 protein','P','The process of introducing a phosphate group to a tyrosine residue of a Stat6 protein.','2013-10-27','NSRP'),(20220,42506,'tyrosine phosphorylation of Stat5 protein','P','The process of introducing a phosphate group to a tyrosine residue of a Stat5 protein.','2013-10-27','NSRP'),(20221,42507,'tyrosine phosphorylation of Stat7 protein','P','The process of introducing a phosphate group to a tyrosine residue of a Stat7 protein.','2013-10-27','NSRP'),(20222,42508,'tyrosine phosphorylation of Stat1 protein','P','The process of introducing a phosphate group to a tyrosine residue of a Stat1 protein.','2013-10-27','NSRP'),(20223,42509,'regulation of tyrosine phosphorylation of STAT protein','P','Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.','2013-10-27','NSRP'),(20224,42510,'regulation of tyrosine phosphorylation of Stat1 protein','P','Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein.','2013-10-27','NSRP'),(20225,42511,'positive regulation of tyrosine phosphorylation of Stat1 protein','P','Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein.','2013-10-27','NSRP'),(20226,42512,'negative regulation of tyrosine phosphorylation of Stat1 protein','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein.','2013-10-27','NSRP'),(20227,42513,'regulation of tyrosine phosphorylation of Stat2 protein','P','Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat2 protein.','2013-10-27','NSRP'),(20228,42514,'negative regulation of tyrosine phosphorylation of Stat2 protein','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein.','2013-10-27','NSRP'),(20229,42515,'positive regulation of tyrosine phosphorylation of Stat2 protein','P','Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein.','2013-10-27','NSRP'),(20230,42516,'regulation of tyrosine phosphorylation of Stat3 protein','P','Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein.','2013-10-27','NSRP'),(20231,42517,'positive regulation of tyrosine phosphorylation of Stat3 protein','P','Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.','2013-10-27','NSRP'),(20232,42518,'negative regulation of tyrosine phosphorylation of Stat3 protein','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein.','2013-10-27','NSRP'),(20233,42519,'regulation of tyrosine phosphorylation of Stat4 protein','P','Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat4 protein.','2013-10-27','NSRP'),(20234,42520,'positive regulation of tyrosine phosphorylation of Stat4 protein','P','Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein.','2013-10-27','NSRP'),(20235,42521,'negative regulation of tyrosine phosphorylation of Stat4 protein','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein.','2013-10-27','NSRP'),(20236,42522,'regulation of tyrosine phosphorylation of Stat5 protein','P','Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein.','2013-10-27','NSRP'),(20237,42523,'positive regulation of tyrosine phosphorylation of Stat5 protein','P','Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein.','2013-10-27','NSRP'),(20238,42524,'negative regulation of tyrosine phosphorylation of Stat5 protein','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein.','2013-10-27','NSRP'),(20239,42525,'regulation of tyrosine phosphorylation of Stat6 protein','P','Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat6 protein.','2013-10-27','NSRP'),(20240,42526,'positive regulation of tyrosine phosphorylation of Stat6 protein','P','Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein.','2013-10-27','NSRP'),(20241,42527,'negative regulation of tyrosine phosphorylation of Stat6 protein','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein.','2013-10-27','NSRP'),(20242,42528,'regulation of tyrosine phosphorylation of Stat7 protein','P','Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat7 protein.','2013-10-27','NSRP'),(20243,42529,'positive regulation of tyrosine phosphorylation of Stat7 protein','P','Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein.','2013-10-27','NSRP'),(20244,42530,'negative regulation of tyrosine phosphorylation of Stat7 protein','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein.','2013-10-27','NSRP'),(20245,42531,'positive regulation of tyrosine phosphorylation of STAT protein','P','Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.','2013-10-27','NSRP'),(20246,42532,'negative regulation of tyrosine phosphorylation of STAT protein','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.','2013-10-27','NSRP'),(20247,42533,'tumor necrosis factor biosynthetic process','P','The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.','2013-10-27','NSRP'),(20248,42534,'regulation of tumor necrosis factor biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.','2013-10-27','NSRP'),(20249,42535,'positive regulation of tumor necrosis factor biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.','2013-10-27','NSRP'),(20250,42536,'negative regulation of tumor necrosis factor biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.','2013-10-27','NSRP'),(20251,42537,'benzene-containing compound metabolic process','P','The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives.','2013-10-27','NSRP'),(20252,42538,'hyperosmotic salinity response','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.','2013-10-27','NSRP'),(20253,42539,'hypotonic salinity response','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.','2013-10-27','NSRP'),(20254,42540,'hemoglobin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids.','2013-10-27','NSRP'),(20255,42541,'hemoglobin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.','2013-10-27','NSRP'),(20256,42542,'response to hydrogen peroxide','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.','2013-10-27','NSRP'),(20257,42543,'protein N-linked glycosylation via arginine','P','The glycosylation of protein via peptidyl-arginine, omega-N-glycosyl-L-arginine.','2013-10-27','NSRP'),(20258,42544,'melibiose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose.','2013-10-27','NSRP'),(20259,42545,'cell wall modification','P','The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly.','2013-10-27','NSRP'),(20260,42546,'cell wall biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.','2013-10-27','NSRP'),(20261,42547,'cell wall modification involved in multidimensional cell growth','P','The series of events resulting in chemical or structural changes to existing cell walls and contribute to multidimensional cell growth.','2013-10-27','NSRP'),(20262,42548,'regulation of photosynthesis, light reaction','P','Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis.','2013-10-27','NSRP'),(20263,42549,'photosystem II stabilization','P','The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis.','2013-10-27','NSRP'),(20264,42550,'photosystem I stabilization','P','The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis.','2013-10-27','NSRP'),(20265,42551,'neuron maturation','P','A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state.','2013-10-27','NSRP'),(20266,42552,'myelination','P','The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.','2013-10-27','NSRP'),(20267,42554,'superoxide anion generation','P','The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways.','2013-10-27','NSRP'),(20268,42555,'MCM complex','C','A hexameric protein complex required for the initiation and regulation of DNA replication.','2013-10-27','NSRP'),(20269,42556,'eukaryotic elongation factor-2 kinase regulator activity','F','Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase.','2013-10-27','NSRP'),(20270,42557,'eukaryotic elongation factor-2 kinase activator activity','F','Increases the activity of the enzyme eukaryotic elongation factor-2 kinase.','2013-10-27','NSRP'),(20271,42558,'pteridine-containing compound metabolic process','P','The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.','2013-10-27','NSRP'),(20272,42559,'pteridine-containing compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.','2013-10-27','NSRP'),(20273,42560,'pteridine-containing compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.','2013-10-27','NSRP'),(20274,42561,'alpha-amyrin synthase activity','F','Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin.','2013-10-27','NSRP'),(20275,42562,'hormone binding','F','Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.','2013-10-27','NSRP'),(20276,42563,'importin alpha-subunit nuclear export complex','C','A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore.','2013-10-27','NSRP'),(20277,42564,'NLS-dependent protein nuclear import complex','C','A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore.','2013-10-27','NSRP'),(20278,42565,'RNA nuclear export complex','C','A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore.','2013-10-27','NSRP'),(20279,42566,'hydrogenosome','C','A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation.','2013-10-27','NSRP'),(20280,42567,'insulin-like growth factor ternary complex','C','A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development.','2013-10-27','NSRP'),(20281,42568,'insulin-like growth factor binary complex','C','A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development.','2013-10-27','NSRP'),(20282,42571,'immunoglobulin complex, circulating','C','An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.','2013-10-27','NSRP'),(20283,42572,'retinol metabolic process','P','The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A.','2013-10-27','NSRP'),(20284,42573,'retinoic acid metabolic process','P','The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A.','2013-10-27','NSRP'),(20285,42574,'retinal metabolic process','P','The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A.','2013-10-27','NSRP'),(20286,42575,'DNA polymerase complex','C','A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA.','2013-10-27','NSRP'),(20287,42576,'aspartyl aminopeptidase activity','F','OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.','2013-10-27','NSRP'),(20288,42577,'lipid phosphatase activity','F','Catalysis of the reaction: a phospholipid + H2O = a lipid + phosphate.','2013-10-27','NSRP'),(20289,42578,'phosphoric ester hydrolase activity','F','Catalysis of the reaction: RPO-R\' + H2O = RPOOH + R\'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.','2013-10-27','NSRP'),(20290,42579,'microbody','C','Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2).','2013-10-27','NSRP'),(20291,42580,'mannosome','C','A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction.','2013-10-27','NSRP'),(20292,42581,'specific granule','C','Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.','2013-10-27','NSRP'),(20293,42582,'azurophil granule','C','Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.','2013-10-27','NSRP'),(20294,42583,'chromaffin granule','C','Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.','2013-10-27','NSRP'),(20295,42584,'chromaffin granule membrane','C','The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine.','2013-10-27','NSRP'),(20296,42585,'germinal vesicle','C','The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.','2013-10-27','NSRP'),(20297,42586,'peptide deformylase activity','F','Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide.','2013-10-27','NSRP'),(20298,42587,'glycogen granule','C','Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface.','2013-10-27','NSRP'),(20299,42588,'zymogen granule','C','A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme.','2013-10-27','NSRP'),(20300,42589,'zymogen granule membrane','C','The lipid bilayer surrounding a zymogen granule.','2013-10-27','NSRP'),(20301,42590,'antigen processing and presentation of exogenous peptide antigen via MHC class I','P','The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(20302,42592,'homeostatic process','P','Any biological process involved in the maintenance of an internal steady state.','2013-10-27','NSRP'),(20303,42593,'glucose homeostasis','P','Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.','2013-10-27','NSRP'),(20304,42594,'response to starvation','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.','2013-10-27','NSRP'),(20305,42595,'behavioral response to starvation','P','Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment.','2013-10-27','NSRP'),(20306,42596,'fear response','P','The response of an organism to a perceived external threat.','2013-10-27','NSRP'),(20307,42597,'periplasmic space','C','The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).','2013-10-27','NSRP'),(20308,42598,'vesicular fraction','C','OBSOLETE: Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized.','2013-10-27','NSRP'),(20309,42599,'lamellar body','C','A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.','2013-10-27','NSRP'),(20310,42600,'chorion','C','A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish.','2013-10-27','NSRP'),(20311,42601,'endospore-forming forespore','C','Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions.','2013-10-27','NSRP'),(20312,42602,'riboflavin reductase (NADPH) activity','F','Catalysis of the reaction: reduced riboflavin + NADP+ = riboflavin + NADPH + 2 H+.','2013-10-27','NSRP'),(20313,42603,'capsule','C','A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication.','2013-10-27','NSRP'),(20314,42605,'peptide antigen binding','F','Interacting selectively and non-covalently with an antigen peptide.','2013-10-27','NSRP'),(20315,42608,'T cell receptor binding','F','Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells.','2013-10-27','NSRP'),(20316,42609,'CD4 receptor binding','F','Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages.','2013-10-27','NSRP'),(20317,42610,'CD8 receptor binding','F','Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes.','2013-10-27','NSRP'),(20318,42611,'MHC protein complex','C','A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen.','2013-10-27','NSRP'),(20319,42612,'MHC class I protein complex','C','A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(20320,42613,'MHC class II protein complex','C','A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen.','2013-10-27','NSRP'),(20321,42614,'CD70 receptor binding','F','Interacting selectively and non-covalently with a CD70, a receptor found on the surface of most activated B cells and some activated T cells.','2013-10-27','NSRP'),(20322,42615,'CD154 receptor binding','F','Interacting selectively and non-covalently with CD154, a receptor found on the surface of some activated lymphocytes.','2013-10-27','NSRP'),(20323,42616,'paclitaxel metabolic process','P','The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment.','2013-10-27','NSRP'),(20324,42617,'paclitaxel biosynthetic process','P','The chemical reactions and pathways resulting in the formation of paclitaxel, an alkaloid compound used as an anticancer treatment.','2013-10-27','NSRP'),(20325,42618,'poly-hydroxybutyrate metabolic process','P','The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells.','2013-10-27','NSRP'),(20326,42619,'poly-hydroxybutyrate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells.','2013-10-27','NSRP'),(20327,42620,'poly(3-hydroxyalkanoate) metabolic process','P','The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria.','2013-10-27','NSRP'),(20328,42621,'poly(3-hydroxyalkanoate) biosynthetic process','P','The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria.','2013-10-27','NSRP'),(20329,42622,'photoreceptor outer segment membrane','C','The membrane surrounding the outer segment of a vertebrate photoreceptor.','2013-10-27','NSRP'),(20330,42623,'ATPase activity, coupled','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.','2013-10-27','NSRP'),(20331,42624,'ATPase activity, uncoupled','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction.','2013-10-27','NSRP'),(20332,42625,'ATPase activity, coupled to transmembrane movement of ions','F','Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate.','2013-10-27','NSRP'),(20333,42626,'ATPase activity, coupled to transmembrane movement of substances','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.','2013-10-27','NSRP'),(20334,42627,'chylomicron','C','A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues.','2013-10-27','NSRP'),(20335,42628,'mating plug formation','P','The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males.','2013-10-27','NSRP'),(20336,42629,'mast cell granule','C','Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase.','2013-10-27','NSRP'),(20337,42630,'behavioral response to water deprivation','P','Any process that results in a change in the behavior of an organism as a result of deprivation of water.','2013-10-27','NSRP'),(20338,42631,'cellular response to water deprivation','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water.','2013-10-27','NSRP'),(20339,42632,'cholesterol homeostasis','P','Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.','2013-10-27','NSRP'),(20340,42633,'hair cycle','P','The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body.','2013-10-27','NSRP'),(20341,42634,'regulation of hair cycle','P','Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.','2013-10-27','NSRP'),(20342,42635,'positive regulation of hair cycle','P','Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.','2013-10-27','NSRP'),(20343,42636,'negative regulation of hair cycle','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair.','2013-10-27','NSRP'),(20344,42637,'catagen','P','The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced.','2013-10-27','NSRP'),(20345,42638,'exogen','P','The shedding phase of the hair cycle.','2013-10-27','NSRP'),(20346,42639,'telogen','P','The resting phase of hair cycle.','2013-10-27','NSRP'),(20347,42640,'anagen','P','The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair.','2013-10-27','NSRP'),(20348,42641,'actomyosin','C','Any complex of actin, myosin, and accessory proteins.','2013-10-27','NSRP'),(20349,42642,'actomyosin, myosin complex part','C','The myosin part of any complex of actin, myosin, and accessory proteins.','2013-10-27','NSRP'),(20350,42643,'actomyosin, actin portion','C','The actin part of any complex of actin, myosin, and accessory proteins.','2013-10-27','NSRP'),(20351,42644,'chloroplast nucleoid','C','The region of a chloroplast to which the DNA is confined.','2013-10-27','NSRP'),(20352,42645,'mitochondrial nucleoid','C','The region of a mitochondrion to which the DNA is confined.','2013-10-27','NSRP'),(20353,42646,'plastid nucleoid','C','The region of a plastid to which the DNA is confined.','2013-10-27','NSRP'),(20354,42647,'proplastid nucleoid','C','The region of a proplastid to which the DNA is confined.','2013-10-27','NSRP'),(20355,42648,'chloroplast chromosome','C','A circular DNA molecule containing chloroplast encoded genes.','2013-10-27','NSRP'),(20356,42649,'prothylakoid','C','Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light.','2013-10-27','NSRP'),(20357,42650,'prothylakoid membrane','C','The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes.','2013-10-27','NSRP'),(20358,42651,'thylakoid membrane','C','The pigmented membrane of any thylakoid.','2013-10-27','NSRP'),(20359,42652,'mitochondrial respiratory chain complex I, peripheral segment','C','The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.','2013-10-27','NSRP'),(20360,42653,'mitochondrial respiratory chain complex I, membrane segment','C','The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix.','2013-10-27','NSRP'),(20361,42654,'ecdysis-triggering hormone receptor activity','F','Combining with ecdysis-triggering hormone to initiate a change in cell activity.','2013-10-27','NSRP'),(20362,42655,'activation of JNKKK activity','P','The initiation of the activity of the inactive enzyme JUN kinase kinase kinase (JNKKK) activity.','2013-10-27','NSRP'),(20363,42656,'JUN kinase kinase kinase kinase activity','F','Catalysis of the phosphorylation and activation of JUN kinase kinase kinases (JNKKKs).','2013-10-27','NSRP'),(20364,42657,'MHC class II protein binding, via lateral surface','F','Interacting selectively and non-covalently with the lateral surface of major histocompatibility complex class II molecules.','2013-10-27','NSRP'),(20365,42658,'MHC class II protein binding, via antigen binding groove','F','Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules.','2013-10-27','NSRP'),(20366,42659,'regulation of cell fate specification','P','Any process that mediates the adoption of a specific fate by a cell.','2013-10-27','NSRP'),(20367,42660,'positive regulation of cell fate specification','P','Any process that activates or enables a cell to adopt a specific fate.','2013-10-27','NSRP'),(20368,42661,'regulation of mesodermal cell fate specification','P','Any process that modulates the frequency, rate or extent of mesoderm cell fate specification.','2013-10-27','NSRP'),(20369,42662,'negative regulation of mesodermal cell fate specification','P','Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification.','2013-10-27','NSRP'),(20370,42663,'regulation of endodermal cell fate specification','P','Any process that mediates the specification of a cell into an endoderm cell.','2013-10-27','NSRP'),(20371,42664,'negative regulation of endodermal cell fate specification','P','Any process that restricts, stops or prevents a cell from specifying into an endoderm cell.','2013-10-27','NSRP'),(20372,42665,'regulation of ectodermal cell fate specification','P','Any process that mediates the specification of a cell into an ectoderm cell.','2013-10-27','NSRP'),(20373,42666,'negative regulation of ectodermal cell fate specification','P','Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell.','2013-10-27','NSRP'),(20374,42667,'auditory receptor cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(20375,42668,'auditory receptor cell fate determination','P','The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(20376,42669,'regulation of auditory receptor cell fate specification','P','Any process that mediates the specification of a cell into an auditory hair cell.','2013-10-27','NSRP'),(20377,42670,'retinal cone cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell.','2013-10-27','NSRP'),(20378,42671,'retinal cone cell fate determination','P','The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(20379,42672,'retinal cone cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(20380,42673,'regulation of retinal cone cell fate specification','P','Any process that mediates the specification of a cell into a retinal cone cell.','2013-10-27','NSRP'),(20381,42675,'compound eye cone cell differentiation','P','The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye.','2013-10-27','NSRP'),(20382,42676,'compound eye cone cell fate commitment','P','The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type.','2013-10-27','NSRP'),(20383,42679,'compound eye cone cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(20384,42680,'compound eye cone cell fate determination','P','The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(20385,42682,'regulation of compound eye cone cell fate specification','P','Any process that mediates the specification of a cell into a compound eye cone cell.','2013-10-27','NSRP'),(20386,42683,'negative regulation of compound eye cone cell fate specification','P','Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell.','2013-10-27','NSRP'),(20387,42684,'cardioblast cell fate commitment','P','The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(20388,42685,'cardioblast cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(20389,42686,'regulation of cardioblast cell fate specification','P','Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.','2013-10-27','NSRP'),(20390,42688,'crystal cell differentiation','P','The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph.','2013-10-27','NSRP'),(20391,42689,'regulation of crystal cell differentiation','P','Any process that modulates the frequency, rate or extent of crystal cell differentiation.','2013-10-27','NSRP'),(20392,42690,'negative regulation of crystal cell differentiation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation.','2013-10-27','NSRP'),(20393,42691,'positive regulation of crystal cell differentiation','P','Any process that activates or increases the frequency, rate or extent of crystal cell differentiation.','2013-10-27','NSRP'),(20394,42692,'muscle cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a muscle cell.','2013-10-27','NSRP'),(20395,42693,'muscle cell fate commitment','P','The process in which the cellular identity of muscle cells is acquired and determined.','2013-10-27','NSRP'),(20396,42694,'muscle cell fate specification','P','The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.','2013-10-27','NSRP'),(20397,42695,'thelarche','P','The beginning of development of the breasts in the female.','2013-10-27','NSRP'),(20398,42696,'menarche','P','The beginning of the menstrual cycle; the first menstrual cycle in an individual.','2013-10-27','NSRP'),(20399,42697,'menopause','P','Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50.','2013-10-27','NSRP'),(20400,42698,'ovulation cycle','P','The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.','2013-10-27','NSRP'),(20401,42699,'follicle-stimulating hormone signaling pathway','P','The series of molecular signals mediated by follicle-stimulating hormone.','2013-10-27','NSRP'),(20402,42700,'luteinizing hormone signaling pathway','P','The series of molecular signals mediated by luteinizing hormone.','2013-10-27','NSRP'),(20403,42701,'progesterone secretion','P','The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta.','2013-10-27','NSRP'),(20404,42702,'uterine wall growth','P','The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels.','2013-10-27','NSRP'),(20405,42703,'menstruation','P','The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus.','2013-10-27','NSRP'),(20406,42704,'uterine wall breakdown','P','The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels.','2013-10-27','NSRP'),(20407,42705,'ocellus photoreceptor cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus.','2013-10-27','NSRP'),(20408,42706,'eye photoreceptor cell fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.','2013-10-27','NSRP'),(20409,42707,'ocellus photoreceptor cell fate commitment','P','The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments.','2013-10-27','NSRP'),(20410,42708,'elastase activity','F','OBSOLETE. Catalysis of the hydrolysis of elastin.','2013-10-27','NSRP'),(20411,42709,'succinate-CoA ligase complex','C','A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP.','2013-10-27','NSRP'),(20412,42710,'biofilm formation','P','A process in which microorganisms irreversibly attach to and grow on a surface and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription.','2013-10-27','NSRP'),(20413,42711,'maternal behavior','P','Female behaviors associated with the care and rearing of offspring.','2013-10-27','NSRP'),(20414,42712,'paternal behavior','P','Male behaviors associated with the care and rearing offspring.','2013-10-27','NSRP'),(20415,42713,'sperm ejaculation','P','The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract.','2013-10-27','NSRP'),(20416,42714,'dosage compensation complex assembly','P','The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes.','2013-10-27','NSRP'),(20417,42715,'dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome','P','The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans.','2013-10-27','NSRP'),(20418,42716,'plasma membrane-derived chromatophore','C','A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria.','2013-10-27','NSRP'),(20419,42717,'plasma membrane-derived chromatophore membrane','C','The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles.','2013-10-27','NSRP'),(20420,42718,'yolk granule','C','Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed.','2013-10-27','NSRP'),(20421,42719,'mitochondrial intermembrane space protein transporter complex','C','Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane.','2013-10-27','NSRP'),(20422,42720,'mitochondrial inner membrane peptidase complex','C','Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space.','2013-10-27','NSRP'),(20423,42721,'mitochondrial inner membrane protein insertion complex','C','A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane.','2013-10-27','NSRP'),(20424,42722,'alpha-beta T cell activation by superantigen','P','The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region.','2013-10-27','NSRP'),(20425,42723,'thiamine-containing compound metabolic process','P','The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it.','2013-10-27','NSRP'),(20426,42724,'thiamine-containing compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds.','2013-10-27','NSRP'),(20427,42725,'thiamine-containing compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it.','2013-10-27','NSRP'),(20428,42726,'flavin-containing compound metabolic process','P','The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.','2013-10-27','NSRP'),(20429,42727,'flavin-containing compound biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.','2013-10-27','NSRP'),(20430,42728,'flavin-containing compound catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position.','2013-10-27','NSRP'),(20431,42729,'DASH complex','C','A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability.','2013-10-27','NSRP'),(20432,42730,'fibrinolysis','P','A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin.','2013-10-27','NSRP'),(20433,42731,'PH domain binding','F','Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.','2013-10-27','NSRP'),(20434,42732,'D-xylose metabolic process','P','The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.','2013-10-27','NSRP'),(20435,42733,'embryonic digit morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe.','2013-10-27','NSRP'),(20436,42734,'presynaptic membrane','C','A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane.','2013-10-27','NSRP'),(20437,42735,'protein body','C','A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins.','2013-10-27','NSRP'),(20438,42736,'NADH kinase activity','F','Catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH.','2013-10-27','NSRP'),(20439,42737,'drug catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease.','2013-10-27','NSRP'),(20440,42738,'exogenous drug catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism.','2013-10-27','NSRP'),(20441,42739,'endogenous drug catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism.','2013-10-27','NSRP'),(20442,42740,'exogenous antibiotic catabolic process','P','The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism.','2013-10-27','NSRP'),(20443,42741,'endogenous antibiotic catabolic process','P','The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism.','2013-10-27','NSRP'),(20444,42742,'defense response to bacterium','P','Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.','2013-10-27','NSRP'),(20445,42743,'hydrogen peroxide metabolic process','P','The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA.','2013-10-27','NSRP'),(20446,42744,'hydrogen peroxide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).','2013-10-27','NSRP'),(20447,42745,'circadian sleep/wake cycle','P','The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm.','2013-10-27','NSRP'),(20448,42746,'circadian sleep/wake cycle, wakefulness','P','The part of the circadian sleep/wake cycle where the organism is not asleep.','2013-10-27','NSRP'),(20449,42747,'circadian sleep/wake cycle, REM sleep','P','A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity.','2013-10-27','NSRP'),(20450,42748,'circadian sleep/wake cycle, non-REM sleep','P','All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions.','2013-10-27','NSRP'),(20451,42749,'regulation of circadian sleep/wake cycle','P','Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.','2013-10-27','NSRP'),(20452,42750,'hibernation','P','Any process in which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs.','2013-10-27','NSRP'),(20453,42751,'estivation','P','Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season.','2013-10-27','NSRP'),(20454,42752,'regulation of circadian rhythm','P','Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.','2013-10-27','NSRP'),(20455,42753,'positive regulation of circadian rhythm','P','Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.','2013-10-27','NSRP'),(20456,42754,'negative regulation of circadian rhythm','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.','2013-10-27','NSRP'),(20457,42755,'eating behavior','P','The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue.','2013-10-27','NSRP'),(20458,42756,'drinking behavior','P','The specific behavior of an organism relating to the intake of liquids, especially water.','2013-10-27','NSRP'),(20459,42757,'giant axon','C','Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses.','2013-10-27','NSRP'),(20460,42758,'long-chain fatty acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22.','2013-10-27','NSRP'),(20461,42759,'long-chain fatty acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22.','2013-10-27','NSRP'),(20462,42760,'very long-chain fatty acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22.','2013-10-27','NSRP'),(20463,42761,'very long-chain fatty acid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22.','2013-10-27','NSRP'),(20464,42762,'regulation of sulfur metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur.','2013-10-27','NSRP'),(20465,42763,'intracellular immature spore','C','A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants.','2013-10-27','NSRP'),(20466,42764,'ascospore-type prospore','C','An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi.','2013-10-27','NSRP'),(20467,42765,'GPI-anchor transamidase complex','C','An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor.','2013-10-27','NSRP'),(20468,42766,'nucleosome mobilization','P','The movement of nucleosomes along a DNA fragment.','2013-10-27','NSRP'),(20469,42767,'ecdysteroid 22-hydroxylase activity','F','Catalysis of the hydroxylation of an ecdysteroid at carbon position 22.','2013-10-27','NSRP'),(20470,42768,'ecdysteroid 2-hydroxylase activity','F','Catalysis of the hydroxylation of an ecdysteroid at carbon position 2.','2013-10-27','NSRP'),(20471,42769,'DNA damage response, detection of DNA damage','P','The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal.','2013-10-27','NSRP'),(20472,42770,'signal transduction in response to DNA damage','P','A cascade of processes induced by the detection of DNA damage within a cell.','2013-10-27','NSRP'),(20473,42771,'intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator','P','A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.','2013-10-27','NSRP'),(20474,42772,'DNA damage response, signal transduction resulting in transcription','P','A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription.','2013-10-27','NSRP'),(20475,42773,'ATP synthesis coupled electron transport','P','The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP.','2013-10-27','NSRP'),(20476,42774,'plasma membrane ATP synthesis coupled electron transport','P','The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane.','2013-10-27','NSRP'),(20477,42775,'mitochondrial ATP synthesis coupled electron transport','P','The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.','2013-10-27','NSRP'),(20478,42776,'mitochondrial ATP synthesis coupled proton transport','P','The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.','2013-10-27','NSRP'),(20479,42777,'plasma membrane ATP synthesis coupled proton transport','P','The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis.','2013-10-27','NSRP'),(20480,42778,'tRNA end turnover','P','The process in which the 3\'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA.','2013-10-27','NSRP'),(20481,42779,'tRNA 3\'-trailer cleavage','P','Cleavage of the 3\'-end of the pre-tRNA as part of the process of generating the mature 3\'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both.','2013-10-27','NSRP'),(20482,42780,'tRNA 3\'-end processing','P','The process in which the 3\' end of a pre-tRNA molecule is converted to that of a mature tRNA.','2013-10-27','NSRP'),(20483,42781,'3\'-tRNA processing endoribonuclease activity','F','Catalysis of the endonucleolytic cleavage of RNA, removing extra 3\' nucleotides from tRNA precursor, generating 3\' termini of tRNAs. A 3\'-hydroxy group is left at the tRNA terminus and a 5\'-phosphoryl group is left at the trailer molecule.','2013-10-27','NSRP'),(20484,42782,'passive evasion of host immune response','P','Any mechanism of immune avoidance that does not directly interfere with the host immune system; for example, some viruses enter a state of latency where their protein production is drastically downregulated, meaning that they are not detected by the host immune system. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(20485,42783,'active evasion of host immune response','P','Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(20486,42784,'active evasion of host immune response via regulation of host complement system','P','Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),