(13910,30137,'COPI-coated vesicle','C','A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport.','2013-10-27','NSRP'),(13911,30139,'endocytic vesicle','C','A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.','2013-10-27','NSRP'),(13912,30140,'trans-Golgi network transport vesicle','C','A vesicle that mediates transport between the trans-Golgi network and other parts of the cell.','2013-10-27','NSRP'),(13913,30141,'secretory granule','C','A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.','2013-10-27','NSRP'),(13914,30142,'Golgi to ER transport vesicle','C','A vesicle that mediates transport from the Golgi to the endoplasmic reticulum.','2013-10-27','NSRP'),(13915,30143,'inter-Golgi transport vesicle','C','A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack).','2013-10-27','NSRP'),(13916,30144,'alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity','F','Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors.','2013-10-27','NSRP'),(13917,30145,'manganese ion binding','F','Interacting selectively and non-covalently with manganese (Mn) ions.','2013-10-27','NSRP'),(13918,30146,'diuresis','P','OBSOLETE. The process of renal water excretion.','2013-10-27','NSRP'),(13919,30147,'natriuresis','P','OBSOLETE. The process of renal sodium excretion.','2013-10-27','NSRP'),(13920,30148,'sphingolipid biosynthetic process','P','The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).','2013-10-27','NSRP'),(13921,30149,'sphingolipid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).','2013-10-27','NSRP'),(13922,30150,'protein import into mitochondrial matrix','P','The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together.','2013-10-27','NSRP'),(13923,30151,'molybdenum ion binding','F','Interacting selectively and non-covalently with molybdenum (Mo) ions.','2013-10-27','NSRP'),(13924,30152,'bacteriocin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.','2013-10-27','NSRP'),(13925,30153,'bacteriocin immunity','P','A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary.','2013-10-27','NSRP'),(13926,30154,'cell differentiation','P','The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism\'s life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.','2013-10-27','NSRP'),(13927,30155,'regulation of cell adhesion','P','Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.','2013-10-27','NSRP'),(13928,30156,'benzodiazepine receptor binding','F','Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR).','2013-10-27','NSRP'),(13929,30157,'pancreatic juice secretion','P','The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach.','2013-10-27','NSRP'),(13930,30158,'protein xylosyltransferase activity','F','Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate.','2013-10-27','NSRP'),(13931,30159,'receptor signaling complex scaffold activity','F','Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex.','2013-10-27','NSRP'),(13932,30160,'GKAP/Homer scaffold activity','F','Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses.','2013-10-27','NSRP'),(13933,30161,'calpain inhibitor activity','F','OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue.','2013-10-27','NSRP'),(13934,30162,'regulation of proteolysis','P','Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.','2013-10-27','NSRP'),(13935,30163,'protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.','2013-10-27','NSRP'),(13936,30164,'protein denaturation','P','Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds.','2013-10-27','NSRP'),(13937,30165,'PDZ domain binding','F','Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.','2013-10-27','NSRP'),(13938,30166,'proteoglycan biosynthetic process','P','The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.','2013-10-27','NSRP'),(13939,30167,'proteoglycan catabolic process','P','The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.','2013-10-27','NSRP'),(13940,30168,'platelet activation','P','A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.','2013-10-27','NSRP'),(13941,30169,'low-density lipoprotein particle binding','F','Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.','2013-10-27','NSRP'),(13942,30170,'pyridoxal phosphate binding','F','Interacting selectively and non-covalently with pyridoxal 5\' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5\' phosphate, the biologically active form of vitamin B6.','2013-10-27','NSRP'),(13943,30171,'voltage-gated proton channel activity','F','Catalysis of the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.','2013-10-27','NSRP'),(13944,30172,'troponin C binding','F','Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex.','2013-10-27','NSRP'),(13945,30173,'integral to Golgi membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the Golgi complex membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(13946,30174,'regulation of DNA-dependent DNA replication initiation','P','Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.','2013-10-27','NSRP'),(13947,30175,'filopodium','C','Thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward.','2013-10-27','NSRP'),(13948,30176,'integral to endoplasmic reticulum membrane','C','Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(13949,30177,'positive regulation of Wnt receptor signaling pathway','P','Any process that activates or increases the frequency, rate or extent of Wnt receptor signaling pathway activity.','2013-10-27','NSRP'),(13950,30178,'negative regulation of Wnt receptor signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt receptor signaling pathway activity.','2013-10-27','NSRP'),(13951,30180,'solute:solute exchange','P','OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction.','2013-10-27','NSRP'),(13952,30181,'sodium:calcium exchange','P','OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell.','2013-10-27','NSRP'),(13953,30182,'neuron differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a neuron.','2013-10-27','NSRP'),(13954,30183,'B cell differentiation','P','The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.','2013-10-27','NSRP'),(13955,30184,'nitric oxide transmembrane transporter activity','F','Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other.','2013-10-27','NSRP'),(13956,30185,'nitric oxide transport','P','The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(13957,30186,'melatonin metabolic process','P','The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine).','2013-10-27','NSRP'),(13958,30187,'melatonin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine).','2013-10-27','NSRP'),(13959,30188,'chaperone regulator activity','F','OBSOLETE. Modulates the activity of a molecular chaperone.','2013-10-27','NSRP'),(13960,30189,'chaperone activator activity','F','OBSOLETE. Increases the activity of a molecular chaperone.','2013-10-27','NSRP'),(13961,30190,'chaperone inhibitor activity','F','OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone.','2013-10-27','NSRP'),(13962,30191,'Hsp70/Hsc70 protein inhibitor activity','F','OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class.','2013-10-27','NSRP'),(13963,30192,'Hsp70/Hsc70 protein regulator activity','F','OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class.','2013-10-27','NSRP'),(13964,30193,'regulation of blood coagulation','P','Any process that modulates the frequency, rate or extent of blood coagulation.','2013-10-27','NSRP'),(13965,30194,'positive regulation of blood coagulation','P','Any process that activates or increases the frequency, rate or extent of blood coagulation.','2013-10-27','NSRP'),(13966,30195,'negative regulation of blood coagulation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation.','2013-10-27','NSRP'),(13967,30196,'cyanide hydratase activity','F','Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide.','2013-10-27','NSRP'),(13968,30197,'extracellular matrix constituent, lubricant activity','F','Functions as a lubricant for an extracellular matrix, such as a mucous membrane.','2013-10-27','NSRP'),(13969,30198,'extracellular matrix organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.','2013-10-27','NSRP'),(13970,30199,'collagen fibril organization','P','Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix.','2013-10-27','NSRP'),(13971,30200,'heparan sulfate proteoglycan catabolic process','P','The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.','2013-10-27','NSRP'),(13972,30201,'heparan sulfate proteoglycan metabolic process','P','The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups.','2013-10-27','NSRP'),(13973,30202,'heparin metabolic process','P','The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.','2013-10-27','NSRP'),(13974,30203,'glycosaminoglycan metabolic process','P','The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties.','2013-10-27','NSRP'),(13975,30204,'chondroitin sulfate metabolic process','P','The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.','2013-10-27','NSRP'),(13976,30205,'dermatan sulfate metabolic process','P','The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues.','2013-10-27','NSRP'),(13977,30206,'chondroitin sulfate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.','2013-10-27','NSRP'),(13978,30207,'chondroitin sulfate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate.','2013-10-27','NSRP'),(13979,30208,'dermatan sulfate biosynthetic process','P','The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.','2013-10-27','NSRP'),(13980,30209,'dermatan sulfate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units.','2013-10-27','NSRP'),(13981,30210,'heparin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.','2013-10-27','NSRP'),(13982,30211,'heparin catabolic process','P','The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.','2013-10-27','NSRP'),(13983,30212,'hyaluronan metabolic process','P','The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.','2013-10-27','NSRP'),(13984,30213,'hyaluronan biosynthetic process','P','The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.','2013-10-27','NSRP'),(13985,30214,'hyaluronan catabolic process','P','The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.','2013-10-27','NSRP'),(13986,30215,'semaphorin receptor binding','F','Interacting selectively and non-covalently with semaphorin receptors.','2013-10-27','NSRP'),(13987,30216,'keratinocyte differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte.','2013-10-27','NSRP'),(13988,30217,'T cell differentiation','P','The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.','2013-10-27','NSRP'),(13989,30218,'erythrocyte differentiation','P','The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.','2013-10-27','NSRP'),(13990,30219,'megakaryocyte differentiation','P','The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte.','2013-10-27','NSRP'),(13991,30220,'platelet formation','P','The process in which platelets bud from long processes extended by megakaryocytes.','2013-10-27','NSRP'),(13992,30221,'basophil differentiation','P','The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell.','2013-10-27','NSRP'),(13993,30222,'eosinophil differentiation','P','The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil.','2013-10-27','NSRP'),(13994,30223,'neutrophil differentiation','P','The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.','2013-10-27','NSRP'),(13995,30224,'monocyte differentiation','P','The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte.','2013-10-27','NSRP'),(13996,30225,'macrophage differentiation','P','The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage.','2013-10-27','NSRP'),(13997,30226,'apolipoprotein receptor activity','F','Combining with an apolipoprotein to initiate a change in cell activity.','2013-10-27','NSRP'),(13998,30227,'apolipoprotein E receptor activity','F','OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity.','2013-10-27','NSRP'),(13999,30228,'lipoprotein particle receptor activity','F','Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.','2013-10-27','NSRP'),(14000,30229,'very-low-density lipoprotein particle receptor activity','F','Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.','2013-10-27','NSRP'),(14001,30232,'insulin control element activator complex','C','Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5\'-flanking region of the insulin gene, and activates ICE-mediated transcription.','2013-10-27','NSRP'),(14002,30233,'deoxynucleotide transmembrane transporter activity','F','Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP.','2013-10-27','NSRP'),(14003,30234,'enzyme regulator activity','F','Modulates the activity of an enzyme.','2013-10-27','NSRP'),(14004,30235,'nitric-oxide synthase regulator activity','F','Modulates the activity of nitric oxide synthase.','2013-10-27','NSRP'),(14005,30237,'female sex determination','P','The specification of female sex of an individual organism.','2013-10-27','NSRP'),(14006,30238,'male sex determination','P','The specification of male sex of an individual organism.','2013-10-27','NSRP'),(14007,30239,'myofibril assembly','P','Formation of myofibrils, the repeating units of striated muscle.','2013-10-27','NSRP'),(14008,30240,'skeletal muscle thin filament assembly','P','The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle.','2013-10-27','NSRP'),(14009,30241,'skeletal muscle myosin thick filament assembly','P','The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle.','2013-10-27','NSRP'),(14010,30242,'peroxisome degradation','P','The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions.','2013-10-27','NSRP'),(14011,30243,'cellulose metabolic process','P','The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.','2013-10-27','NSRP'),(14012,30244,'cellulose biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.','2013-10-27','NSRP'),(14013,30245,'cellulose catabolic process','P','The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation.','2013-10-27','NSRP'),(14014,30246,'carbohydrate binding','F','Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.','2013-10-27','NSRP'),(14015,30247,'polysaccharide binding','F','Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.','2013-10-27','NSRP'),(14016,30248,'cellulose binding','F','Interacting selectively and non-covalently with cellulose.','2013-10-27','NSRP'),(14017,30249,'guanylate cyclase regulator activity','F','Modulates the activity of guanylate cyclase.','2013-10-27','NSRP'),(14018,30250,'guanylate cyclase activator activity','F','Increases the activity of guanylate cyclase.','2013-10-27','NSRP'),(14019,30251,'guanylate cyclase inhibitor activity','F','Stops, prevents or reduces the activity of guanylate cyclase.','2013-10-27','NSRP'),(14020,30252,'growth hormone secretion','P','The regulated release of growth hormone from secretory granules into the blood.','2013-10-27','NSRP'),(14021,30253,'protein secretion by the type I secretion system','P','The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.','2013-10-27','NSRP'),(14022,30254,'protein secretion by the type III secretion system','P','The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.','2013-10-27','NSRP'),(14023,30255,'protein secretion by the type IV secretion system','P','The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system.','2013-10-27','NSRP'),(14024,30256,'type I protein secretion system complex','C','A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space.','2013-10-27','NSRP'),(14025,30257,'type III protein secretion system complex','C','A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase.','2013-10-27','NSRP'),(14026,30258,'lipid modification','P','The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid.','2013-10-27','NSRP'),(14027,30259,'lipid glycosylation','P','Covalent attachment of a glycosyl residue to a lipid molecule.','2013-10-27','NSRP'),(14028,30260,'entry into host cell','P','The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(14029,30261,'chromosome condensation','P','The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.','2013-10-27','NSRP'),(14030,30262,'apoptotic nuclear changes','P','Alterations undergone by nuclei at the molecular and morphological level and that contribute to the execution phase of apoptosis.','2013-10-27','NSRP'),(14031,30263,'apoptotic chromosome condensation','P','The compaction of chromatin during apoptosis.','2013-10-27','NSRP'),(14032,30264,'nuclear fragmentation involved in apoptotic nuclear change','P','The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA.','2013-10-27','NSRP'),(14033,30265,'phospholipase C-activating rhodopsin mediated signaling pathway','P','The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).','2013-10-27','NSRP'),(14034,30266,'quinate 3-dehydrogenase (NAD+) activity','F','Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+.','2013-10-27','NSRP'),(14035,30267,'glyoxylate reductase (NADP) activity','F','Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.','2013-10-27','NSRP'),(14036,30268,'methylenetetrahydromethanopterin dehydrogenase activity','F','Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420.','2013-10-27','NSRP'),(14037,30269,'tetrahydromethanopterin S-methyltransferase activity','F','Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM.','2013-10-27','NSRP'),(14038,30270,'formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity','F','Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran.','2013-10-27','NSRP'),(14039,30271,'chymase activity','F','OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa.','2013-10-27','NSRP'),(14040,30272,'5-formyltetrahydrofolate cyclo-ligase activity','F','Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate.','2013-10-27','NSRP'),(14041,30273,'melanin-concentrating hormone receptor activity','F','Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity.','2013-10-27','NSRP'),(14042,30274,'LIM domain binding','F','Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions.','2013-10-27','NSRP'),(14043,30275,'LRR domain binding','F','Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein.','2013-10-27','NSRP'),(14044,30276,'clathrin binding','F','Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.','2013-10-27','NSRP'),(14045,30277,'maintenance of gastrointestinal epithelium','P','Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents.','2013-10-27','NSRP'),(14046,30278,'regulation of ossification','P','Any process that modulates the frequency, rate or extent of bone formation.','2013-10-27','NSRP'),(14047,30279,'negative regulation of ossification','P','Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation.','2013-10-27','NSRP'),(14048,30280,'structural constituent of epidermis','F','The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure.','2013-10-27','NSRP'),(14049,30281,'structural constituent of cutaneous appendage','F','The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers.','2013-10-27','NSRP'),(14050,30282,'bone mineralization','P','The deposition of calcium phosphate in bone tissue.','2013-10-27','NSRP'),(14051,30283,'testosterone dehydrogenase [NAD(P)] activity','F','Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+.','2013-10-27','NSRP'),(14052,30284,'estrogen receptor activity','F','Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function.','2013-10-27','NSRP'),(14053,30285,'integral to synaptic vesicle membrane','C','Penetrating at least one phospholipid bilayer of a synaptic vesicle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(14054,30286,'dynein complex','C','Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.','2013-10-27','NSRP'),(14055,30287,'cell wall-bounded periplasmic space','C','The region between the plasma membrane and the cell wall, as found in organisms such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria.','2013-10-27','NSRP'),(14056,30288,'outer membrane-bounded periplasmic space','C','The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin cell wall.','2013-10-27','NSRP'),(14057,30289,'protein phosphatase 4 complex','C','The complex formed by the catalytic subunit of protein phosphatase 4 plus a regulatory subunit.','2013-10-27','NSRP'),(14058,30290,'sphingolipid activator protein activity','F','Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase.','2013-10-27','NSRP'),(14059,30291,'protein serine/threonine kinase inhibitor activity','F','Stops, prevents or reduces the activity of a protein serine/threonine kinase.','2013-10-27','NSRP'),(14060,30292,'protein tyrosine kinase inhibitor activity','F','Stops, prevents or reduces the activity of a protein tyrosine kinase.','2013-10-27','NSRP'),(14061,30293,'transmembrane receptor protein tyrosine kinase inhibitor activity','F','Stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase.','2013-10-27','NSRP'),(14062,30294,'receptor signaling protein tyrosine kinase inhibitor activity','F','Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase.','2013-10-27','NSRP'),(14063,30295,'protein kinase activator activity','F','Increases the activity of a protein kinase, an enzyme which phosphorylates a protein.','2013-10-27','NSRP'),(14064,30296,'protein tyrosine kinase activator activity','F','Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.','2013-10-27','NSRP'),(14065,30297,'transmembrane receptor protein tyrosine kinase activator activity','F','Increases the activity of a transmembrane receptor protein tyrosine kinase.','2013-10-27','NSRP'),(14066,30298,'receptor signaling protein tyrosine kinase activator activity','F','Increases the activity of a receptor signaling protein tyrosine kinase.','2013-10-27','NSRP'),(14067,30299,'intestinal cholesterol absorption','P','Uptake of cholesterol into the blood by absorption from the small intestine.','2013-10-27','NSRP'),(14068,30300,'regulation of intestinal cholesterol absorption','P','Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption.','2013-10-27','NSRP'),(14069,30301,'cholesterol transport','P','The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(14070,30302,'deoxynucleotide transport','P','The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5\' position of deoxyribose, into, out of or within a cell.','2013-10-27','NSRP'),(14071,30303,'stromelysin 2 activity','F','OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1\', P2\' and P3\' are hydrophobic residues; action on collagen types III, IV and V is weak.','2013-10-27','NSRP'),(14072,30304,'trypsin inhibitor activity','F','OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin.','2013-10-27','NSRP'),(14073,30305,'heparanase activity','F','Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains.','2013-10-27','NSRP'),(14074,30306,'ADP-ribosylation factor binding','F','Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells.','2013-10-27','NSRP'),(14075,30307,'positive regulation of cell growth','P','Any process that activates or increases the frequency, rate, extent or direction of cell growth.','2013-10-27','NSRP'),(14076,30308,'negative regulation of cell growth','P','Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.','2013-10-27','NSRP'),(14077,30309,'poly-N-acetyllactosamine metabolic process','P','The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.','2013-10-27','NSRP'),(14078,30310,'poly-N-acetyllactosamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.','2013-10-27','NSRP'),(14079,30311,'poly-N-acetyllactosamine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n.','2013-10-27','NSRP'),(14080,30312,'external encapsulating structure','C','A structure that lies outside the plasma membrane and surrounds the entire cell.','2013-10-27','NSRP'),(14081,30313,'cell envelope','C','An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present.','2013-10-27','NSRP'),(14082,30314,'junctional membrane complex','C','Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules).','2013-10-27','NSRP'),(14083,30315,'T-tubule','C','Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.','2013-10-27','NSRP'),(14084,30316,'osteoclast differentiation','P','The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.','2013-10-27','NSRP'),(14085,30317,'sperm motility','P','Any process involved in the controlled movement of a sperm cell.','2013-10-27','NSRP'),(14086,30318,'melanocyte differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a melanocyte.','2013-10-27','NSRP'),(14087,30319,'cellular di-, tri-valent inorganic anion homeostasis','P','OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell.','2013-10-27','NSRP'),(14088,30320,'cellular monovalent inorganic anion homeostasis','P','Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell.','2013-10-27','NSRP'),(14089,30321,'transepithelial chloride transport','P','The directed movement of chloride ions from one side of an epithelium to the other.','2013-10-27','NSRP'),(14090,30322,'stabilization of membrane potential','P','The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.','2013-10-27','NSRP'),(14091,30323,'respiratory tube development','P','The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract.','2013-10-27','NSRP'),(14092,30324,'lung development','P','The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.','2013-10-27','NSRP'),(14093,30325,'adrenal gland development','P','The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells.','2013-10-27','NSRP'),(14094,30326,'embryonic limb morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping.','2013-10-27','NSRP'),(14095,30327,'prenylated protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of prenylated proteins.','2013-10-27','NSRP'),(14096,30328,'prenylcysteine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.','2013-10-27','NSRP'),(14097,30329,'prenylcysteine metabolic process','P','The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.','2013-10-27','NSRP'),(14098,30330,'DNA damage response, signal transduction by p53 class mediator','P','A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.','2013-10-27','NSRP'),(14099,30331,'estrogen receptor binding','F','Interacting selectively and non-covalently with an estrogen receptor.','2013-10-27','NSRP'),(14100,30332,'cyclin binding','F','Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis.','2013-10-27','NSRP'),(14101,30334,'regulation of cell migration','P','Any process that modulates the frequency, rate or extent of cell migration.','2013-10-27','NSRP'),(14102,30335,'positive regulation of cell migration','P','Any process that activates or increases the frequency, rate or extent of cell migration.','2013-10-27','NSRP'),(14103,30336,'negative regulation of cell migration','P','Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.','2013-10-27','NSRP'),(14104,30337,'DNA polymerase processivity factor activity','F','An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it.','2013-10-27','NSRP'),(14105,30338,'CMP-N-acetylneuraminate monooxygenase activity','F','Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O.','2013-10-27','NSRP'),(14106,30339,'fatty-acyl-ethyl-ester synthase activity','F','Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol.','2013-10-27','NSRP'),(14107,30340,'hyaluronate lyase activity','F','Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine.','2013-10-27','NSRP'),(14108,30341,'chondroitin AC lyase activity','F','Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups.','2013-10-27','NSRP'),(14109,30342,'1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity','F','Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol).','2013-10-27','NSRP'),(14110,30343,'vitamin D3 25-hydroxylase activity','F','Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O.','2013-10-27','NSRP'),(14111,30345,'structural constituent of tooth enamel','F','The action of a molecule that contributes to the structural integrity of tooth enamel.','2013-10-27','NSRP'),(14112,30346,'protein phosphatase 2B binding','F','Interacting selectively and non-covalently with the enzyme protein phosphatase 2B.','2013-10-27','NSRP'),(14113,30347,'syntaxin-2 binding','F','Interacting selectively and non-covalently with the SNAP receptor syntaxin-2.','2012-03-14','NSRP'),(14114,30348,'syntaxin-3 binding','F','Interacting selectively and non-covalently with the SNAP receptor syntaxin-3.','2013-10-27','NSRP'),(14115,30349,'syntaxin-13 binding','F','Interacting selectively and non-covalently with the SNAP receptor syntaxin-13.','2012-03-14','NSRP'),(14116,30350,'iron-responsive element binding','F','Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5\'- and 3\'-untranslated regions of mRNAs encoding many iron-binding proteins.','2013-10-27','NSRP'),(14117,30351,'inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity','F','Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate.','2013-10-27','NSRP'),(14118,30352,'inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity','F','Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate.','2013-10-27','NSRP'),(14119,30353,'fibroblast growth factor receptor antagonist activity','F','Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist.','2013-10-27','NSRP'),(14120,30354,'melanin-concentrating hormone activity','F','The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals.','2013-10-27','NSRP'),(14121,30355,'small nucleolar ribonucleoprotein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14122,30356,'small cytoplasmic ribonucleoprotein','F','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14123,30359,'protein phosphatase type 2B regulator activity','F','Modulation of the activity of the enzyme protein phosphatase type 2B.','2013-10-27','NSRP'),(14124,30362,'protein phosphatase type 4 regulator activity','F','Modulation of the activity of the enzyme protein phosphatase type 4.','2013-10-27','NSRP'),(14125,30363,'pre-mRNA cleavage factor activity','F','OBSOLETE. Any activity required for the process of mRNA cleavage.','2013-10-27','NSRP'),(14126,30364,'cleavage and polyadenylylation specificity factor activity','F','OBSOLETE. A factor required in mRNA 3\' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions.','2013-10-27','NSRP'),(14127,30365,'cleavage stimulation factor activity','F','OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3\' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide.','2013-10-27','NSRP'),(14128,30366,'Mo-molybdopterin synthase activity','F','Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.','2013-10-27','NSRP'),(14129,30367,'interleukin-17 receptor binding','F','Interacting selectively and non-covalently with the interleukin-17 receptor.','2013-10-27','NSRP'),(14130,30368,'interleukin-17 receptor activity','F','Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(14131,30369,'ICAM-3 receptor activity','F','Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.','2013-10-27','NSRP'),(14132,30370,'intercellular adhesion molecule-3 receptor binding','F','Interacting selectively and non-covalently with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1.','2013-10-27','NSRP'),(14133,30371,'translation repressor activity','F','Antagonizes ribosome-mediated translation of mRNA into a polypeptide.','2013-10-27','NSRP'),(14134,30372,'high molecular weight B cell growth factor receptor binding','F','Interacting selectively and non-covalently with the high molecular weight B cell growth factor receptor.','2013-10-27','NSRP'),(14135,30373,'high molecular weight B cell growth factor receptor activity','F','Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity.','2013-10-27','NSRP'),(14136,30374,'ligand-dependent nuclear receptor transcription coactivator activity','F','The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.','2013-10-27','NSRP'),(14137,30375,'thyroid hormone receptor coactivator activity','F','The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.','2013-10-27','NSRP'),(14138,30377,'U-plasminogen activator receptor activity','F','Combining with the urokinase plasminogen activator to initiate a change in cell activity.','2013-10-27','NSRP'),(14139,30378,'serine racemase activity','F','Catalysis of the synthesis of free D-serine from L-serine.','2013-10-27','NSRP'),(14140,30379,'neurotensin receptor activity, non-G-protein coupled','F','Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins.','2013-10-27','NSRP'),(14141,30380,'interleukin-17E receptor binding','F','Interacting selectively and non-covalently with the interleukin-17E receptor.','2013-10-27','NSRP'),(14142,30381,'chorion-containing eggshell pattern formation','P','The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects.','2013-10-27','NSRP'),(14143,30382,'sperm mitochondrion organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm.','2013-10-27','NSRP'),(14144,30383,'host-pathogen interaction','P','OBSOLETE. Any interaction between a pathogen and its host organism.','2013-10-27','NSRP'),(14145,30385,'ferredoxin:thioredoxin reductase activity','F','Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide.','2013-10-27','NSRP'),(14146,30386,'ferredoxin:thioredoxin reductase complex','C','A protein complex that possesses ferredoxin:thioredoxin reductase activity.','2013-10-27','NSRP'),(14147,30387,'fructosamine-3-kinase activity','F','Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase.','2013-10-27','NSRP'),(14148,30388,'fructose 1,6-bisphosphate metabolic process','P','The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis.','2013-10-27','NSRP'),(14149,30389,'fructosamine metabolic process','P','The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.','2013-10-27','NSRP'),(14150,30391,'fructosamine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.','2013-10-27','NSRP'),(14151,30392,'fructosamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group.','2013-10-27','NSRP'),(14152,30393,'fructoselysine metabolic process','P','The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group.','2013-10-27','NSRP'),(14153,30394,'fructoseglycine metabolic process','P','The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group.','2013-10-27','NSRP'),(14154,30395,'lactose binding','F','Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk.','2013-10-27','NSRP'),(14155,30397,'membrane disassembly','P','The controlled breakdown of any cell membrane in the context of a normal process such as autophagy.','2013-10-27','NSRP'),(14156,30398,'peroxisomal membrane disassembly','P','The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation.','2013-10-27','NSRP'),(14157,30399,'autophagic membrane disassembly','P','The controlled breakdown of the membranes of autophagic vacuoles.','2013-10-27','NSRP'),(14158,30400,'protease substrate recruitment factor activity','F','OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity.','2013-10-27','NSRP'),(14159,30401,'transcription antiterminator activity','F','OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed.','2013-10-27','NSRP'),(14160,30402,'matrilysin-2 activity','F','OBSOLETE. Was not defined before being made obsolete.','2013-10-27','NSRP'),(14161,30403,'collagenase 4 activity','F','OBSOLETE. Was not defined before being made obsolete.','2013-10-27','NSRP'),(14162,30404,'collagenase 3 activity','F','OBSOLETE. Was not defined before being made obsolete.','2013-10-27','NSRP'),(14163,30405,'matrix metalloproteinase 19 activity','F','OBSOLETE. Was not defined before being made obsolete.','2013-10-27','NSRP'),(14164,30406,'matrix metalloproteinase 25 activity','F','OBSOLETE. Was not defined before being made obsolete.','2013-10-27','NSRP'),(14165,30407,'formimidoyltransferase activity','F','Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid.','2013-10-27','NSRP'),(14166,30408,'glycine formimidoyltransferase activity','F','Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine.','2013-10-27','NSRP'),(14167,30409,'glutamate formimidoyltransferase activity','F','Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate.','2013-10-27','NSRP'),(14168,30410,'nicotianamine synthase activity','F','Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5\'-thioadenosine + 3 H(+) + nicotianamine.','2013-10-27','NSRP'),(14169,30411,'scytalone dehydratase activity','F','Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O.','2013-10-27','NSRP'),(14170,30412,'formimidoyltetrahydrofolate cyclodeaminase activity','F','Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+).','2013-10-27','NSRP'),(14171,30413,'competence pheromone activity','F','A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence.','2013-10-27','NSRP'),(14172,30414,'peptidase inhibitor activity','F','Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.','2013-10-27','NSRP'),(14173,30415,'carboxypeptidase A inhibitor activity','F','OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A.','2013-10-27','NSRP'),(14174,30416,'methylamine metabolic process','P','The chemical reactions and pathways involving methylamine (CH3NH2).','2013-10-27','NSRP'),(14175,30417,'nicotianamine metabolic process','P','The chemical reactions and pathways involving nicotianamine, 2(S),3\'2(S),3\'\'(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.','2013-10-27','NSRP'),(14176,30418,'nicotianamine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3\'2(S),3\'\'(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.','2013-10-27','NSRP'),(14177,30419,'nicotianamine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3\'2(S),3\'\'(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid.','2013-10-27','NSRP'),(14178,30420,'establishment of competence for transformation','P','The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation.','2013-10-27','NSRP'),(14179,30421,'defecation','P','The expulsion of feces from the rectum.','2013-10-27','NSRP'),(14180,30422,'production of siRNA involved in RNA interference','P','Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference.','2013-10-27','NSRP'),(14181,30423,'targeting of mRNA for destruction involved in RNA interference','P','The process in which small interfering RNAs target cognate mRNA molecules for degradation.','2013-10-27','NSRP'),(14182,30424,'axon','C','The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.','2013-10-27','NSRP'),(14183,30425,'dendrite','C','A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.','2013-10-27','NSRP'),(14184,30426,'growth cone','C','The migrating motile tip of a growing nerve cell axon or dendrite.','2013-10-27','NSRP'),(14185,30427,'site of polarized growth','C','Any part of a cell where non-isotropic growth takes place.','2013-10-27','NSRP'),(14186,30428,'cell septum','C','A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.','2013-10-27','NSRP'),(14187,30429,'kynureninase activity','F','Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine.','2013-10-27','NSRP'),(14188,30430,'host cell cytoplasm','C','The cytoplasm of a host cell.','2013-10-27','NSRP'),(14189,30431,'sleep','P','Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain.','2013-10-27','NSRP'),(14190,30432,'peristalsis','P','A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards.','2013-10-27','NSRP'),(14191,30433,'ER-associated protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins.','2013-10-27','NSRP'),(14192,30435,'sporulation resulting in formation of a cellular spore','P','The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.','2013-10-27','NSRP'),(14193,30436,'asexual sporulation','P','The formation of spores derived from the products of mitosis. Examples of this process are found in Bacterial species.','2013-10-27','NSRP'),(14194,30437,'ascospore formation','P','The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).','2013-10-27','NSRP'),(14195,30438,'MAPKKK cascade during sporulation (sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14196,30439,'activation of MAPK during sporulation (sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14197,30440,'activation of MAPKK during sporulation (sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14198,30441,'activation of MAPKKK during sporulation (sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14199,30442,'inactivation of MAPK during sporulation (sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14200,30443,'nuclear translocation of MAPK during sporulation (sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14201,30444,'microtubule depolymerization during nuclear congression','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14202,30445,'yeast-form cell wall','C','The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form.','2013-10-27','NSRP'),(14203,30446,'hyphal cell wall','C','The cell wall surrounding a fungal hypha.','2013-10-27','NSRP'),(14204,30447,'filamentous growth','P','The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.','2013-10-27','NSRP'),(14205,30448,'hyphal growth','P','Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls.','2013-10-27','NSRP'),(14206,30449,'regulation of complement activation','P','Any process that modulates the frequency, rate or extent of complement activation.','2013-10-27','NSRP'),(14207,30450,'regulation of complement activation, classical pathway','P','Any process that modulates the frequency, rate or extent of the classical pathway of complement activation.','2013-10-27','NSRP'),(14208,30451,'regulation of complement activation, alternative pathway','P','Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation.','2013-10-27','NSRP'),(14209,30455,'MAPKKK cascade (mating sensu Fungi)','P','OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus.','2013-10-27','NSRP'),(14210,30456,'activation of MAPK (mating sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14211,30457,'activation of MAPKK (mating sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14212,30458,'activation of MAPKKK (mating sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14213,30459,'inactivation of MAPK (mating sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14214,30460,'nuclear translocation of MAPK (mating sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14215,30463,'cell aging (sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14216,30464,'aging dependent sterility (sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14217,30465,'autophagic death (sensu Fungi)','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14218,30466,'chromatin silencing at silent mating-type cassette','P','Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.','2013-10-27','NSRP'),(14219,30470,'spore germination (sensu Fungi)','P','OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751).','2013-10-27','NSRP'),(14220,30471,'spindle pole body and microtubule cycle (sensu Fungi)','P','OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751).','2013-10-27','NSRP'),(14221,30472,'mitotic spindle organization in nucleus','P','A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level.','2013-10-27','NSRP'),(14222,30473,'nuclear migration along microtubule','P','The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins.','2013-10-27','NSRP'),(14223,30474,'spindle pole body duplication','P','Construction of a new spindle pole body.','2013-10-27','NSRP'),(14224,30476,'ascospore wall assembly','P','The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(14225,30478,'actin cap','C','Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(14226,30479,'actin cortical patch','C','A discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae.','2013-10-27','NSRP'),(14227,30484,'muscle fiber','C','OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle.','2013-10-27','NSRP'),(14228,30485,'smooth muscle contractile fiber','C','The contractile fiber of smooth muscle cells.','2013-10-27','NSRP'),(14229,30486,'smooth muscle dense body','C','Electron-dense region associated with a smooth muscle contractile fiber.','2013-10-27','NSRP'),(14230,30487,'inositol-4,5-bisphosphate 5-phosphatase activity','F','Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate.','2013-10-27','NSRP'),(14231,30488,'tRNA methylation','P','The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule.','2013-10-27','NSRP'),(14232,30489,'processing of 27S pre-rRNA','P','OBSOLETE (was not defined before being made obsolete).','2013-10-27','NSRP'),(14233,30490,'maturation of SSU-rRNA','P','Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.','2013-10-27','NSRP'),(14234,30491,'heteroduplex formation','P','The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules.','2013-10-27','NSRP'),(14235,30492,'hemoglobin binding','F','Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin.','2013-10-27','NSRP'),(14236,30493,'bacteriochlorophyll metabolic process','P','The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants.','2013-10-27','NSRP'),(14237,30494,'bacteriochlorophyll biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants.','2013-10-27','NSRP'),(14238,30495,'bacteriochlorophyll catabolic process','P','The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants.','2013-10-27','NSRP'),(14239,30496,'midbody','C','A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.','2013-10-27','NSRP'),(14240,30497,'fatty acid elongation','P','The elongation of a fatty acid chain by the sequential addition of two-carbon units.','2013-10-27','NSRP'),(14241,30500,'regulation of bone mineralization','P','Any process that modulates the frequency, rate or extent of bone mineralization.','2013-10-27','NSRP'),(14242,30501,'positive regulation of bone mineralization','P','Any process that activates or increases the frequency, rate or extent of bone mineralization.','2013-10-27','NSRP'),(14243,30502,'negative regulation of bone mineralization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.','2013-10-27','NSRP'),(14244,30504,'inorganic diphosphate transmembrane transporter activity','F','Catalysis of the transfer of inorganic diphosphate across a membrane.','2013-10-27','NSRP'),(14245,30505,'inorganic diphosphate transport','P','The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(14246,30506,'ankyrin binding','F','Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.','2013-10-27','NSRP'),(14247,30507,'spectrin binding','F','Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.','2013-10-27','NSRP'),(14248,30508,'thiol-disulfide exchange intermediate activity','F','OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions.','2013-10-27','NSRP'),(14249,30509,'BMP signaling pathway','P','A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.','2013-10-27','NSRP'),(14250,30510,'regulation of BMP signaling pathway','P','Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.','2013-10-27','NSRP'),(14251,30511,'positive regulation of transforming growth factor beta receptor signaling pathway','P','Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity.','2013-10-27','NSRP'),(14252,30512,'negative regulation of transforming growth factor beta receptor signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.','2013-10-27','NSRP'),(14253,30513,'positive regulation of BMP signaling pathway','P','Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.','2013-10-27','NSRP'),(14254,30514,'negative regulation of BMP signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.','2013-10-27','NSRP'),(14255,30515,'snoRNA binding','F','Interacting selectively and non-covalently with small nucleolar RNA.','2013-10-27','NSRP'),(14256,30516,'regulation of axon extension','P','Any process that modulates the rate, direction or extent of axon extension.','2013-10-27','NSRP'),(14257,30517,'negative regulation of axon extension','P','Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth.','2013-10-27','NSRP'),(14258,30518,'intracellular steroid hormone receptor signaling pathway','P','A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands.','2013-10-27','NSRP'),(14259,30519,'snoRNP binding','F','Interacting selectively and non-covalently with any part of a small nucleolar ribonucleoprotein particle.','2013-10-27','NSRP'),(14260,30520,'intracellular estrogen receptor signaling pathway','P','Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription).','2013-10-27','NSRP'),(14261,30521,'androgen receptor signaling pathway','P','Any series of molecular signals generated as a consequence of an androgen binding to its receptor.','2013-10-27','NSRP'),(14262,30522,'intracellular receptor signaling pathway','P','Any series of molecular signals initiated by a ligand binding to an receptor located within a cell.','2013-10-27','NSRP'),(14263,30523,'dihydrolipoamide S-acyltransferase activity','F','Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide.','2013-10-27','NSRP'),(14264,30526,'granulocyte macrophage colony-stimulating factor receptor complex','C','The heterodimeric receptor for granulocyte macrophage colony-stimulating factor.','2013-10-27','NSRP'),(14265,30527,'structural constituent of chromatin','F','The action of a molecule that contributes to the structural integrity of chromatin.','2013-10-27','NSRP'),(14266,30528,'transcription regulator activity','F','OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor.','2013-10-27','NSRP'),(14267,30529,'ribonucleoprotein complex','C','A macromolecular complex containing both protein and RNA molecules.','2013-10-27','NSRP'),(14268,30530,'heterogeneous nuclear ribonucleoprotein complex','C','OBSOLETE. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA.','2013-10-27','NSRP'),(14269,30531,'small cytoplasmic ribonucleoprotein complex','C','OBSOLETE. A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm.','2013-10-27','NSRP'),(14270,30532,'small nuclear ribonucleoprotein complex','C','A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs.','2013-10-27','NSRP'),(14271,30533,'triplet codon-amino acid adaptor activity','F','The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis.','2013-10-27','NSRP'),(14272,30534,'adult behavior','P','Behavior in a fully developed and mature organism.','2013-10-27','NSRP'),(14273,30535,'adult feeding behavior (sensu Insecta)','P','OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects.','2013-10-27','NSRP'),(14274,30536,'larval feeding behavior','P','Feeding behavior in a larval (immature) organism.','2013-10-27','NSRP'),(14275,30537,'larval behavior','P','Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics.','2013-10-27','NSRP'),(14276,30538,'embryonic genitalia morphogenesis','P','The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized.','2013-10-27','NSRP'),(14277,30539,'male genitalia development','P','The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure.','2013-10-27','NSRP'),(14278,30540,'female genitalia development','P','The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure.','2013-10-27','NSRP'),(14279,30541,'plasmid partitioning','P','Any process in which plasmids are segregated or distributed into daughter cells upon cell division.','2013-10-27','NSRP'),(14280,30543,'2-micrometer plasmid partitioning','P','The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division.','2013-10-27','NSRP'),(14281,30544,'Hsp70 protein binding','F','Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size.','2013-10-27','NSRP'),(14282,30545,'receptor regulator activity','F','The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed.','2013-10-27','NSRP'),(14283,30546,'receptor activator activity','F','The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased.','2013-10-27','NSRP'),(14284,30547,'receptor inhibitor activity','F','The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased.','2013-10-27','NSRP'),(14285,30548,'acetylcholine receptor regulator activity','F','Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed.','2013-10-27','NSRP'),(14286,30549,'acetylcholine receptor activator activity','F','Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased.','2013-10-27','NSRP'),(14287,30550,'acetylcholine receptor inhibitor activity','F','Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased.','2013-10-27','NSRP'),(14288,30551,'cyclic nucleotide binding','F','Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.','2013-10-27','NSRP'),(14289,30552,'cAMP binding','F','Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14290,30553,'cGMP binding','F','Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14291,30554,'adenyl nucleotide binding','F','Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.','2013-10-27','NSRP'),(14292,30555,'RNA modification guide activity','F','Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14293,30556,'rRNA modification guide activity','F','Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14294,30557,'tRNA modification guide activity','F','Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14295,30558,'RNA pseudouridylation guide activity','F','Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14296,30559,'rRNA pseudouridylation guide activity','F','Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14297,30560,'tRNA pseudouridylation guide activity','F','Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14298,30561,'RNA 2\'-O-ribose methylation guide activity','F','Specifies the site of 2\'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14299,30562,'rRNA 2\'-O-ribose methylation guide activity','F','Specifies the site of 2\'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14300,30563,'snRNA 2\'-O-ribose methylation guide activity','F','Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2\'-O-ribose methylations to a small nuclear RNA molecule.','2013-10-27','NSRP'),(14301,30564,'tRNA 2\'-O-ribose methylation guide activity','F','Specifies the site of 2\'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14302,30565,'snRNA pseudouridylation guide activity','F','Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule.','2013-10-27','NSRP'),(14303,30566,'snRNA modification guide activity','F','Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue.','2013-10-27','NSRP'),(14304,30567,'thrombin activator activity','F','OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin.','2013-10-27','NSRP'),(14305,30568,'plasmin inhibitor activity','F','OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin.','2013-10-27','NSRP'),(14306,30569,'chymotrypsin inhibitor activity','F','OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin.','2013-10-27','NSRP'),(14307,30570,'pectate lyase activity','F','Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends.','2013-10-27','NSRP'),(14308,30572,'phosphatidyltransferase activity','F','Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group.','2013-10-27','NSRP'),(14309,30573,'bile acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.','2013-10-27','NSRP'),(14310,30574,'collagen catabolic process','P','The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.','2013-10-27','NSRP'),(14311,30575,'nuclear body organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.','2013-10-27','NSRP'),(14312,30576,'Cajal body organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors.','2013-10-27','NSRP'),(14313,30577,'Lands organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies.','2013-10-27','NSRP'),(14314,30578,'PML body organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia).','2013-10-27','NSRP'),(14315,30579,'ubiquitin-dependent SMAD protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.','2013-10-27','NSRP'),(14316,30580,'quinone cofactor methyltransferase activity','F','Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1).','2013-10-27','NSRP'),(14317,30581,'symbiont intracellular protein transport in host','P','The directed movement of a symbiont\'s proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(14318,30582,'fruiting body development','P','The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. A fruiting body is a multicellular structure that contains spores.','2013-10-27','NSRP'),(14319,30583,'fruiting body development in cellular response to starvation','P','The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. The process begins when cells respond to a lack of nutrients in the environment and ends when the fruiting body is a mature structure.','2013-10-27','NSRP'),(14320,30584,'sporocarp development','P','The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea.','2013-10-27','NSRP'),(14321,30585,'phosphoenolpyruvate carboxykinase (diphosphate) activity','F','Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate.','2013-10-27','NSRP'),(14322,30586,'[methionine synthase] reductase activity','F','Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+.','2013-10-27','NSRP'),(14323,30587,'sorocarp development','P','The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.','2013-10-27','NSRP'),(14324,30588,'pseudocleavage','P','Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis.','2013-10-27','NSRP'),(14325,30589,'pseudocleavage involved in syncytial blastoderm formation','P','Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(14326,30590,'first cell cycle pseudocleavage','P','A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms.','2013-10-27','NSRP'),(14327,30591,'NAD DNA ADP-ribosyltransferase activity','F','Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2\'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2\'-deoxyguanosine and its beta form.','2013-10-27','NSRP'),(14328,30592,'DNA ADP-ribosylation','P','The covalent attachment of an ADP-ribosyl group to the amino group at N2 of a 2\'-deoxyguanosine residue in double-stranded DNA.','2013-10-27','NSRP'),(14329,30593,'neutrophil chemotaxis','P','The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.','2013-10-27','NSRP'),(14330,30594,'neurotransmitter receptor activity','F','Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.','2013-10-27','NSRP'),(14331,30595,'leukocyte chemotaxis','P','The movement of a leukocyte in response to an external stimulus.','2013-10-27','NSRP'),(14332,30596,'alpha-L-rhamnosidase activity','F','Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.','2013-10-27','NSRP'),(14333,30597,'RNA glycosylase activity','F','Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule.','2013-10-27','NSRP'),(14334,30598,'rRNA N-glycosylase activity','F','Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species.','2013-10-27','NSRP'),(14335,30599,'pectinesterase activity','F','Catalysis of the reaction: pectin + n H2O = n methanol + pectate.','2013-10-27','NSRP'),(14336,30600,'feruloyl esterase activity','F','Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide.','2013-10-27','NSRP'),(14337,30601,'aminopeptidase B activity','F','OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1\' is not Pro. Also acts on arylamides of Arg and Lys.','2013-10-27','NSRP'),(14338,30602,'chymosin activity','F','OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein.','2013-10-27','NSRP'),(14339,30603,'oxaloacetase activity','F','Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate.','2013-10-27','NSRP'),(14340,30604,'1-deoxy-D-xylulose-5-phosphate reductoisomerase activity','F','Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH.','2013-10-27','NSRP'),(14341,30611,'arsenate reductase activity','F','Catalysis of the interconversion of arsenate and arsenite.','2013-10-27','NSRP'),(14342,30612,'arsenate reductase (thioredoxin) activity','F','Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin.','2013-10-27','NSRP'),(14343,30613,'oxidoreductase activity, acting on phosphorus or arsenic in donors','F','Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.','2013-10-27','NSRP'),(14344,30614,'oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor','F','Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide.','2013-10-27','NSRP'),(14345,30616,'transforming growth factor beta receptor, common-partner cytoplasmic mediator activity','F','A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription.','2013-10-27','NSRP'),(14346,30617,'transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity','F','A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators.','2013-10-27','NSRP'),(14347,30618,'transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity','F','A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription.','2013-10-27','NSRP'),(14348,30619,'U1 snRNA binding','F','Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA).','2013-10-27','NSRP'),(14349,30620,'U2 snRNA binding','F','Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA).','2013-10-27','NSRP'),(14350,30621,'U4 snRNA binding','F','Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA).','2013-10-27','NSRP'),(14351,30622,'U4atac snRNA binding','F','Interacting selectively and non-covalently with the U4atac small nuclear RNA (U4atac snRNA).','2013-10-27','NSRP'),(14352,30623,'U5 snRNA binding','F','Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA).','2013-10-27','NSRP'),(14353,30624,'U6atac snRNA binding','F','Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA).','2013-10-27','NSRP'),(14354,30625,'U11 snRNA binding','F','Interacting selectively and non-covalently with the U11 small nuclear RNA (U11 snRNA).','2013-10-27','NSRP'),(14355,30626,'U12 snRNA binding','F','Interacting selectively and non-covalently with the U12 small nuclear RNA (U12 snRNA).','2013-10-27','NSRP'),(14356,30627,'pre-mRNA 5\'-splice site binding','F','Interacting selectively and non-covalently with the pre-mRNA 5\' splice site sequence.','2013-10-27','NSRP'),(14357,30628,'pre-mRNA 3\'-splice site binding','F','Interacting selectively and non-covalently with the pre-mRNA 3\' splice site sequence.','2013-10-27','NSRP'),(14358,30629,'U6 snRNA 3\'-end binding','F','Interacting selectively and non-covalently with the 3\' end of the U6 small nuclear RNA (U6 snRNA).','2013-10-27','NSRP'),(14359,30631,'pyrrolysine incorporation','P','The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases.','2013-10-27','NSRP'),(14360,30632,'D-alanine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid.','2013-10-27','NSRP'),(14361,30633,'D-alanine family amino acid catabolic process','P','The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids.','2013-10-27','NSRP'),(14362,30634,'carbon fixation by acetyl-CoA pathway','P','A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2).','2013-10-27','NSRP'),(14363,30635,'acetate derivative metabolic process','P','OBSOLETE. The chemical reactions and pathways involving derivatives of acetic acid.','2013-10-27','NSRP'),(14364,30636,'acetate derivative biosynthetic process','P','OBSOLETE. The chemical reactions and pathways resulting in the formation of derivatives of acetic acid.','2013-10-27','NSRP'),(14365,30637,'acetate derivative catabolic process','P','OBSOLETE. The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid.','2013-10-27','NSRP'),(14366,30638,'polyketide metabolic process','P','The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps.','2013-10-27','NSRP'),(14367,30639,'polyketide biosynthetic process','P','The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps.','2013-10-27','NSRP'),(14368,30640,'polyketide catabolic process','P','The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps.','2013-10-27','NSRP'),(14369,30641,'regulation of cellular pH','P','Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment.','2013-10-27','NSRP'),(14370,30642,'cellular sulfate ion homeostasis','P','Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell.','2013-10-27','NSRP'),(14371,30643,'cellular phosphate ion homeostasis','P','Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell.','2013-10-27','NSRP'),(14372,30644,'cellular chloride ion homeostasis','P','Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell.','2013-10-27','NSRP'),(14373,30645,'glucose catabolic process to butyrate','P','The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum.','2013-10-27','NSRP'),(14374,30647,'aminoglycoside antibiotic metabolic process','P','The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.','2013-10-27','NSRP'),(14375,30648,'aminoglycoside antibiotic biosynthetic process','P','The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.','2013-10-27','NSRP'),(14376,30649,'aminoglycoside antibiotic catabolic process','P','The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin.','2013-10-27','NSRP'),(14377,30650,'peptide antibiotic metabolic process','P','The chemical reactions and pathways involving peptides with antibiotic activity.','2013-10-27','NSRP'),(14378,30651,'peptide antibiotic biosynthetic process','P','The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity.','2013-10-27','NSRP'),(14379,30652,'peptide antibiotic catabolic process','P','The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity.','2013-10-27','NSRP'),(14380,30653,'beta-lactam antibiotic metabolic process','P','The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins.','2013-10-27','NSRP'),(14381,30654,'beta-lactam antibiotic biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins.','2013-10-27','NSRP'),(14382,30655,'beta-lactam antibiotic catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins.','2013-10-27','NSRP'),(14383,30656,'regulation of vitamin metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.','2013-10-27','NSRP'),(14384,30657,'regulation of coenzyme and prosthetic group metabolic process','P','OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups.','2013-10-27','NSRP'),(14385,30658,'transport vesicle membrane','C','The lipid bilayer surrounding a transport vesicle.','2013-10-27','NSRP'),(14386,30659,'cytoplasmic vesicle membrane','C','The lipid bilayer surrounding a cytoplasmic vesicle.','2013-10-27','NSRP'),(14387,30660,'Golgi-associated vesicle membrane','C','The lipid bilayer surrounding a vesicle associated with the Golgi apparatus.','2013-10-27','NSRP'),(14388,30661,'chitosome membrane','C','The lipid bilayer surrounding a chitosome.','2013-10-27','NSRP'),(14389,30662,'coated vesicle membrane','C','The lipid bilayer surrounding a coated vesicle.','2013-10-27','NSRP'),(14390,30663,'COPI-coated vesicle membrane','C','The lipid bilayer surrounding a COPI-coated vesicle.','2013-10-27','NSRP'),(14391,30665,'clathrin-coated vesicle membrane','C','The lipid bilayer surrounding a clathrin-coated vesicle.','2013-10-27','NSRP'),(14392,30666,'endocytic vesicle membrane','C','The lipid bilayer surrounding an endocytic vesicle.','2013-10-27','NSRP'),(14393,30667,'secretory granule membrane','C','The lipid bilayer surrounding a secretory granule.','2013-10-27','NSRP'),(14394,30668,'merozoite dense granule membrane','C','The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites.','2013-10-27','NSRP'),(14395,30669,'clathrin-coated endocytic vesicle membrane','C','The lipid bilayer surrounding a clathrin-coated endocytic vesicle.','2013-10-27','NSRP'),(14396,30670,'phagocytic vesicle membrane','C','The lipid bilayer surrounding a phagocytic vesicle.','2013-10-27','NSRP'),(14397,30671,'clathrin-coated phagocytic vesicle membrane','C','The lipid bilayer surrounding a clathrin-coated phagocytic vesicle.','2013-10-27','NSRP'),(14398,30672,'synaptic vesicle membrane','C','The lipid bilayer surrounding a synaptic vesicle.','2013-10-27','NSRP'),(14399,30673,'axolemma','C','The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.','2013-10-27','NSRP'),(14400,30674,'protein binding, bridging','F','The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.','2013-10-27','NSRP'),(14401,30675,'Rac GTPase activator activity','F','Increases the rate of GTP hydrolysis by a GTPase of the Rac family.','2013-10-27','NSRP'),(14402,30676,'Rac guanyl-nucleotide exchange factor activity','F','Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.','2013-10-27','NSRP'),(14403,30677,'ribonuclease P complex','C','A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5\' end of tRNAs.','2013-10-27','NSRP'),(14404,30678,'mitochondrial ribonuclease P complex','C','A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5\' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule.','2013-10-27','NSRP'),(14405,30679,'cyanelle ribonuclease P complex','C','A ribonuclease P complex located in the cyanelle, where it catalyzes the 5\' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules.','2013-10-27','NSRP'),(14406,30680,'dimeric ribonuclease P complex','C','A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species.','2013-10-27','NSRP'),(14407,30681,'multimeric ribonuclease P complex','C','A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species.','2013-10-27','NSRP'),(14408,30682,'evasion or tolerance of host defense response','P','Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism\'s defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(14409,30683,'evasion or tolerance by virus of host immune response','P','Any process, either active or passive, by which a virus avoids the effects of the host organism\'s immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction.','2013-10-27','NSRP'),(14410,30684,'preribosome','C','Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis.','2013-10-27','NSRP'),(14411,30685,'nucleolar preribosome','C','Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis.','2013-10-27','NSRP'),(14412,30686,'90S preribosome','C','A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.','2013-10-27','NSRP'),(14413,30687,'preribosome, large subunit precursor','C','A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.','2013-10-27','NSRP'),(14414,30688,'preribosome, small subunit precursor','C','A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.','2013-10-27','NSRP'),(14415,30689,'Noc complex','C','Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis.','2013-10-27','NSRP'),(14416,30690,'Noc1p-Noc2p complex','C','A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis.','2013-10-27','NSRP'),(14417,30691,'Noc2p-Noc3p complex','C','A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis.','2013-10-27','NSRP'),(14418,30692,'Noc4p-Nop14p complex','C','A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis.','2013-10-27','NSRP'),(14419,30693,'caspase activity','F','OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue.','2013-10-27','NSRP'),(14420,30694,'bacterial-type flagellum basal body, rod','C','The central portion of the flagellar basal body, which spans the periplasm and threads through the rings. Examples of this component are found in Bacterial species.','2013-10-27','NSRP'),(14421,30695,'GTPase regulator activity','F','Modulates the rate of GTP hydrolysis by a GTPase.','2013-10-27','NSRP'),(14422,30696,'tRNA (m5U54) methyltransferase activity','F','Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule.','2013-10-27','NSRP'),(14423,30697,'S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes.','2013-10-27','NSRP'),(14424,30698,'5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity','F','Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria.','2013-10-27','NSRP'),(14425,30699,'glycine reductase activity','F','Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin.','2013-10-27','NSRP'),(14426,30700,'glycine reductase complex','C','Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C.','2013-10-27','NSRP'),(14427,30701,'NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity','F','Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase].','2013-10-27','NSRP'),(14428,30702,'chromatin silencing at centromere','P','Repression of transcription of centromeric DNA by altering the structure of chromatin.','2013-10-27','NSRP'),(14429,30703,'eggshell formation','P','Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration.','2013-10-27','NSRP'),(14430,30704,'vitelline membrane formation','P','Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg.','2013-10-27','NSRP'),(14431,30705,'cytoskeleton-dependent intracellular transport','P','The directed movement of substances along cytoskeletal elements such as microfilaments or microtubules within a cell.','2013-10-27','NSRP'),(14432,30706,'germarium-derived oocyte differentiation','P','The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster.','2013-10-27','NSRP'),(14433,30707,'ovarian follicle cell development','P','The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.','2013-10-27','NSRP'),(14434,30708,'germarium-derived female germ-line cyst encapsulation','P','Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(14435,30709,'border follicle cell delamination','P','The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration.','2013-10-27','NSRP'),(14436,30710,'regulation of border follicle cell delamination','P','Any process that regulates the frequency, rate or extent of border cell delamination.','2013-10-27','NSRP'),(14437,30711,'positive regulation of border follicle cell delamination','P','Any process that increases the frequency, rate or extent of border cell delamination.','2013-10-27','NSRP'),(14438,30712,'negative regulation of border follicle cell delamination','P','Any process that decreases the frequency, rate or extent of border cell delamination.','2013-10-27','NSRP'),(14439,30713,'ovarian follicle cell stalk formation','P','Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(14440,30714,'anterior/posterior axis specification, follicular epithelium','P','Polarization of the follicle cells of an insect ovary along the anterior/posterior axis.','2013-10-27','NSRP'),(14441,30715,'oocyte growth in germarium-derived egg chamber','P','The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(14442,30716,'oocyte fate determination','P','The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed.','2013-10-27','NSRP'),(14443,30717,'karyosome formation','P','The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome.','2013-10-27','NSRP'),(14444,30718,'germ-line stem cell maintenance','P','Any process involved in preventing uncommitted germ-line stem cells from differentiating as another cell type.','2013-10-27','NSRP'),(14445,30719,'P granule organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.','2013-10-27','NSRP'),(14446,30720,'oocyte localization involved in germarium-derived egg chamber formation','P','Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber.','2013-10-27','NSRP'),(14447,30721,'spectrosome organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome.','2013-10-27','NSRP'),(14448,30722,'establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification','P','The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. In the insect oocyte, for example, the nucleus is repositioned to a dorso-anterior position.','2013-10-27','NSRP'),(14449,30723,'ovarian fusome organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions.','2013-10-27','NSRP'),(14450,30724,'testicular fusome organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome.','2013-10-27','NSRP'),(14451,30725,'germline ring canal formation','P','Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts.','2013-10-27','NSRP'),(14452,30726,'male germline ring canal formation','P','Formation of the intercellular bridges that connect the germ-line cells of a male cyst.','2013-10-27','NSRP'),(14453,30727,'germarium-derived female germ-line cyst formation','P','Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster.','2013-10-27','NSRP'),(14454,30728,'ovulation','P','The release of a mature ovum/oocyte from an ovary.','2013-10-27','NSRP'),(14455,30729,'acetoacetate-CoA ligase activity','F','Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+).','2013-10-27','NSRP'),(14456,30730,'sequestering of triglyceride','P','The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system.','2013-10-27','NSRP'),(14457,30731,'guanidinoacetate N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+).','2013-10-27','NSRP'),(14458,30732,'methionine S-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine.','2013-10-27','NSRP'),(14459,30733,'fatty acid O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester.','2013-10-27','NSRP'),(14460,30734,'polysaccharide O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units.','2013-10-27','NSRP'),(14461,30735,'carnosine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+).','2013-10-27','NSRP'),(14462,30736,'phenol O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+).','2013-10-27','NSRP'),(14463,30737,'iodophenol O-methyltransferase activity','F','Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14464,30738,'tyramine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14465,30739,'O-demethylpuromycin O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin.','2013-10-27','NSRP'),(14466,30740,'inositol 3-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14467,30741,'inositol 1-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14468,30742,'GTP-dependent protein binding','F','Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP.','2013-10-27','NSRP'),(14469,30743,'rRNA (adenosine-2\'-O-)-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2\'-O-methyladenosine.','2013-10-27','NSRP'),(14470,30744,'luteolin O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4\',5,7-trihydroxy-3\'-methoxyflavone + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14471,30745,'dimethylhistidine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine.','2013-10-27','NSRP'),(14472,30746,'isoflavone 4\'-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4\'-O-methylisoflavone.','2013-10-27','NSRP'),(14473,30747,'indolepyruvate C-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate.','2013-10-27','NSRP'),(14474,30748,'amine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine.','2013-10-27','NSRP'),(14475,30749,'loganate O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin.','2013-10-27','NSRP'),(14476,30750,'putrescine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14477,30751,'licodione 2\'-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2\'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14478,30752,'5-hydroxyfuranocoumarin 5-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin.','2013-10-27','NSRP'),(14479,30753,'8-hydroxyfuranocoumarin 8-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin.','2013-10-27','NSRP'),(14480,30754,'apigenin 4\'-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4\'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4\'-methoxy-5,7-dihydroxyflavone.','2013-10-27','NSRP'),(14481,30755,'quercetin 3-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3\',4\'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3\',4\'-tetrahydroxy-flavone.','2013-10-27','NSRP'),(14482,30756,'isoorientin 3\'-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin.','2013-10-27','NSRP'),(14483,30757,'3-methylquercitin 7-O-methyltransferase activity','F','Catalysis of the reaction: 3\',4\',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3\',4\',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(14484,30758,'3,7-dimethylquercitin 4\'-O-methyltransferase activity','F','Catalysis of the reaction: 3\',4\',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3\',5-dihydroxy-3,4\',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14485,30759,'methylquercetagetin 6-O-methyltransferase activity','F','Catalysis of the reaction: 3\',4\',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3\',4\',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14486,30760,'pyridine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(14487,30761,'8-hydroxyquercitin 8-O-methyltransferase activity','F','Catalysis of the reaction: 3,3\',4\',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3\',4\',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14488,30762,'tetrahydrocolumbamine 2-O-methyltransferase activity','F','Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine.','2013-10-27','NSRP'),(14489,30763,'isobutyraldoxime O-methyltransferase activity','F','Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14490,30766,'11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline.','2013-10-27','NSRP'),(14491,30767,'3-hydroxyanthranilate 4-C-methyltransferase activity','F','Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14492,30768,'16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity','F','Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+).','2013-10-27','NSRP'),(14493,30769,'macrocin O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin.','2013-10-27','NSRP'),(14494,30770,'demethylmacrocin O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin.','2013-10-27','NSRP'),(14495,30771,'N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity','F','Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14496,30772,'tryptophan 2-C-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+).','2013-10-27','NSRP'),(14497,30773,'6-hydroxymellein O-methyltransferase activity','F','Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14498,30774,'anthranilate N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14499,30775,'glucuronoxylan 4-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate.','2013-10-27','NSRP'),(14500,30776,'(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline.','2013-10-27','NSRP'),(14501,30777,'(S)-scoulerine 9-O-methyltransferase activity','F','Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14502,30778,'columbamine O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine.','2013-10-27','NSRP'),(14503,30779,'10-hydroxydihydrosanguinarine 10-O-methyltransferase activity','F','Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+).','2013-10-27','NSRP'),(14504,30780,'12-hydroxydihydrochelirubine 12-O-methyltransferase activity','F','Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+).','2013-10-27','NSRP'),(14505,30781,'6-O-methylnorlaudanosoline 5\'-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline.','2013-10-27','NSRP'),(14506,30782,'(S)-tetrahydroprotoberberine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine.','2013-10-27','NSRP'),(14507,30783,'[cytochrome c]-methionine S-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine.','2013-10-27','NSRP'),(14508,30784,'3\'-hydroxy-N-methyl-(S)-coclaurine 4\'-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + 3\'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline.','2013-10-27','NSRP'),(14509,30785,'[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine.','2013-10-27','NSRP'),(14510,30786,'(RS)-norcoclaurine 6-O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine.','2013-10-27','NSRP'),(14511,30787,'inositol 4-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14512,30788,'precorrin-2 C20-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A.','2013-10-27','NSRP'),(14513,30789,'precorrin-3B C17-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4.','2013-10-27','NSRP'),(14514,30790,'chlorophenol O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole.','2013-10-27','NSRP'),(14515,30791,'arsenite methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.','2013-10-27','NSRP'),(14516,30792,'methylarsonite methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.','2013-10-27','NSRP'),(14517,30793,'3\'-demethylstaurosporine O-methyltransferase activity','F','Catalysis of the reaction: 3\'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine.','2013-10-27','NSRP'),(14518,30794,'(S)-coclaurine-N-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine.','2013-10-27','NSRP'),(14519,30795,'jasmonate O-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate.','2013-10-27','NSRP'),(14520,30796,'cycloartenol 24-C-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14521,30797,'24-methylenesterol C-methyltransferase activity','F','Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+).','2013-10-27','NSRP'),(14522,30798,'trans-aconitate 2-methyltransferase activity','F','Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine.','2013-10-27','NSRP'),(14523,30799,'regulation of cyclic nucleotide metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.','2013-10-27','NSRP'),(14524,30800,'negative regulation of cyclic nucleotide metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.','2013-10-27','NSRP'),(14525,30801,'positive regulation of cyclic nucleotide metabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides.','2013-10-27','NSRP'),(14526,30802,'regulation of cyclic nucleotide biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.','2013-10-27','NSRP'),(14527,30803,'negative regulation of cyclic nucleotide biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.','2013-10-27','NSRP'),(14528,30804,'positive regulation of cyclic nucleotide biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides.','2013-10-27','NSRP'),(14529,30805,'regulation of cyclic nucleotide catabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides.','2013-10-27','NSRP'),(14530,30806,'negative regulation of cyclic nucleotide catabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides.','2013-10-27','NSRP'),(14531,30807,'positive regulation of cyclic nucleotide catabolic process','P','Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides.','2013-10-27','NSRP'),(14532,30808,'regulation of nucleotide biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.','2013-10-27','NSRP'),(14533,30809,'negative regulation of nucleotide biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.','2013-10-27','NSRP'),(14534,30810,'positive regulation of nucleotide biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.','2013-10-27','NSRP'),(14535,30811,'regulation of nucleotide catabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.','2013-10-27','NSRP'),(14536,30812,'negative regulation of nucleotide catabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.','2013-10-27','NSRP'),(14537,30813,'positive regulation of nucleotide catabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.','2013-10-27','NSRP'),(14538,30814,'regulation of cAMP metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14539,30815,'negative regulation of cAMP metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14540,30816,'positive regulation of cAMP metabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14541,30817,'regulation of cAMP biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14542,30818,'negative regulation of cAMP biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14543,30819,'positive regulation of cAMP biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14544,30820,'regulation of cAMP catabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14545,30821,'negative regulation of cAMP catabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14546,30822,'positive regulation of cAMP catabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate).','2013-10-27','NSRP'),(14547,30823,'regulation of cGMP metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP.','2013-10-27','NSRP'),(14548,30824,'negative regulation of cGMP metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP.','2013-10-27','NSRP'),(14549,30825,'positive regulation of cGMP metabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP.','2013-10-27','NSRP'),(14550,30826,'regulation of cGMP biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP.','2013-10-27','NSRP'),(14551,30827,'negative regulation of cGMP biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP.','2013-10-27','NSRP'),(14552,30828,'positive regulation of cGMP biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP.','2013-10-27','NSRP'),(14553,30829,'regulation of cGMP catabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP.','2013-10-27','NSRP'),(14554,30830,'negative regulation of cGMP catabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP.','2013-10-27','NSRP'),(14555,30831,'positive regulation of cGMP catabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP.','2013-10-27','NSRP'),(14556,30832,'regulation of actin filament length','P','Any process that controls the length of actin filaments in a cell.','2013-10-27','NSRP'),(14557,30833,'regulation of actin filament polymerization','P','Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.','2013-10-27','NSRP'),(14558,30834,'regulation of actin filament depolymerization','P','Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament.','2013-10-27','NSRP'),(14559,30835,'negative regulation of actin filament depolymerization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.','2013-10-27','NSRP'),(14560,30836,'positive regulation of actin filament depolymerization','P','Any process that activates or increases the frequency, rate or extent of actin depolymerization.','2013-10-27','NSRP'),(14561,30837,'negative regulation of actin filament polymerization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.','2013-10-27','NSRP'),(14562,30838,'positive regulation of actin filament polymerization','P','Any process that activates or increases the frequency, rate or extent of actin polymerization.','2013-10-27','NSRP'),(14563,30839,'regulation of intermediate filament polymerization','P','Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament.','2013-10-27','NSRP'),(14564,30840,'negative regulation of intermediate filament polymerization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization.','2013-10-27','NSRP'),(14565,30841,'positive regulation of intermediate filament polymerization','P','Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization.','2013-10-27','NSRP'),(14566,30842,'regulation of intermediate filament depolymerization','P','Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament.','2013-10-27','NSRP'),(14567,30843,'negative regulation of intermediate filament depolymerization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization.','2013-10-27','NSRP'),(14568,30844,'positive regulation of intermediate filament depolymerization','P','Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization.','2013-10-27','NSRP'),(14569,30845,'phospholipase C-inhibiting G-protein coupled receptor signaling pathway','P','A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).','2013-10-27','NSRP'),(14570,30846,'termination of RNA polymerase II transcription, poly(A)-coupled','P','The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3\' end is coupled to transcription termination.','2013-10-27','NSRP'),(14571,30847,'termination of RNA polymerase II transcription, exosome-dependent','P','The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3\'-end.','2013-10-27','NSRP'),(14572,30848,'threo-3-hydroxyaspartate ammonia-lyase activity','F','Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate.','2013-10-27','NSRP'),(14573,30849,'autosome','C','Any chromosome other than a sex chromosome.','2013-10-27','NSRP'),(14574,30850,'prostate gland development','P','The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.','2013-10-27','NSRP'),(14575,30851,'granulocyte differentiation','P','The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.','2013-10-27','NSRP'),(14576,30852,'regulation of granulocyte differentiation','P','Any process that modulates the frequency, rate or extent of granulocyte differentiation.','2013-10-27','NSRP'),(14577,30853,'negative regulation of granulocyte differentiation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.','2013-10-27','NSRP'),(14578,30854,'positive regulation of granulocyte differentiation','P','Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.','2013-10-27','NSRP'),(14579,30855,'epithelial cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.','2013-10-27','NSRP'),(14580,30856,'regulation of epithelial cell differentiation','P','Any process that modulates the frequency, rate or extent of epithelial cell differentiation.','2013-10-27','NSRP'),(14581,30857,'negative regulation of epithelial cell differentiation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.','2013-10-27','NSRP'),(14582,30858,'positive regulation of epithelial cell differentiation','P','Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.','2013-10-27','NSRP'),(14583,30859,'polarized epithelial cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis.','2013-10-27','NSRP'),(14584,30860,'regulation of polarized epithelial cell differentiation','P','Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation.','2013-10-27','NSRP'),(14585,30861,'negative regulation of polarized epithelial cell differentiation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation.','2013-10-27','NSRP'),(14586,30862,'positive regulation of polarized epithelial cell differentiation','P','Any process that activates or increases the rate or extent of polarized epithelial cell differentiation.','2013-10-27','NSRP'),(14587,30863,'cortical cytoskeleton','C','The portion of the cytoskeleton that lies just beneath the plasma membrane.','2013-10-27','NSRP'),(14588,30864,'cortical actin cytoskeleton','C','The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.','2013-10-27','NSRP'),(14589,30865,'cortical cytoskeleton organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.','2013-10-27','NSRP'),(14590,30866,'cortical actin cytoskeleton organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.','2013-10-27','NSRP'),(14591,30867,'rough endoplasmic reticulum membrane','C','The lipid bilayer surrounding the rough endoplasmic reticulum.','2013-10-27','NSRP'),(14592,30868,'smooth endoplasmic reticulum membrane','C','The lipid bilayer surrounding the smooth endoplasmic reticulum.','2013-10-27','NSRP'),(14593,30869,'RENT complex','C','A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit.','2013-10-27','NSRP'),(14594,30870,'Mre11 complex','C','Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.','2013-10-27','NSRP'),(14595,30874,'nucleolar chromatin','C','The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA.','2013-10-27','NSRP'),(14596,30875,'rDNA protrusion','C','Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining.','2013-10-27','NSRP'),(14597,30876,'interleukin-20 receptor complex','C','A protein complex that binds interleukin-20; comprises an alpha and a beta subunit.','2013-10-27','NSRP'),(14598,30877,'beta-catenin destruction complex','C','A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.','2013-10-27','NSRP'),(14599,30878,'thyroid gland development','P','The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.','2013-10-27','NSRP'),(14600,30879,'mammary gland development','P','The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.','2013-10-27','NSRP'),(14601,30880,'RNA polymerase complex','C','Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits.','2013-10-27','NSRP'),(14602,30881,'beta-2-microglobulin binding','F','Interacting selectively and non-covalently with beta-2-microglobulin.','2013-10-27','NSRP'),(14603,30882,'lipid antigen binding','F','Interacting selectively and non-covalently with a lipid antigen.','2013-10-27','NSRP'),(14604,30883,'endogenous lipid antigen binding','F','Interacting selectively and non-covalently with an endogenous cellular lipid antigen.','2013-10-27','NSRP'),(14605,30884,'exogenous lipid antigen binding','F','Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids).','2013-10-27','NSRP'),(14606,30885,'regulation of myeloid dendritic cell activation','P','Any process that modulates the frequency or rate of myeloid dendritic cell activation.','2013-10-27','NSRP'),(14607,30886,'negative regulation of myeloid dendritic cell activation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.','2013-10-27','NSRP'),(14608,30887,'positive regulation of myeloid dendritic cell activation','P','Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation.','2013-10-27','NSRP'),(14609,30888,'regulation of B cell proliferation','P','Any process that modulates the frequency, rate or extent of B cell proliferation.','2013-10-27','NSRP'),(14610,30889,'negative regulation of B cell proliferation','P','Any process that stops, prevents or reduces the rate or extent of B cell proliferation.','2013-10-27','NSRP'),(14611,30890,'positive regulation of B cell proliferation','P','Any process that activates or increases the rate or extent of B cell proliferation.','2013-10-27','NSRP'),(14612,30891,'VCB complex','C','A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.','2013-10-27','NSRP'),(14613,30892,'mitotic cohesin complex','C','A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.','2013-10-27','NSRP'),(14614,30893,'meiotic cohesin complex','C','A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.','2013-10-27','NSRP'),(14615,30894,'replisome','C','A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.','2013-10-27','NSRP'),(14616,30895,'apolipoprotein B mRNA editing enzyme complex','C','Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP).','2013-10-27','NSRP'),(14617,30896,'checkpoint clamp complex','C','Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.','2013-10-27','NSRP'),(14618,30897,'HOPS complex','C','A multimeric protein complex that associates with the vacuolar membrane and is involved in homotypic vacuole fusion and vacuole protein sorting. For example, the Saccharomyces complex contains Vps41p, Vam6p, Pep5p, Vps16p, Pep3p, and Vps33p.','2013-10-27','NSRP'),(14619,30898,'actin-dependent ATPase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate.','2013-10-27','NSRP'),(14620,30899,'calcium-dependent ATPase activity','F','Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+).','2013-10-27','NSRP'),(14621,30900,'forebrain development','P','The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).','2013-10-27','NSRP'),(14622,30901,'midbrain development','P','The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).','2013-10-27','NSRP'),(14623,30902,'hindbrain development','P','The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).','2013-10-27','NSRP'),(14624,30903,'notochord development','P','The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.','2013-10-27','NSRP'),(14625,30904,'retromer complex','C','A conserved multimeric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. For example, the budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p.','2013-10-27','NSRP'),(14626,30905,'retromer complex, outer shell','C','One of two subcomplexes that combine to form the retromer, believed to be peripherally associated with the membrane. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer.','2013-10-27','NSRP'),(14627,30906,'retromer complex, inner shell','C','One of two subcomplexes that combine to form the retromer, believed to be closely associated with the membrane. In budding yeast the complex comprises Vps35p, Vps29p, and Vps26p.','2013-10-27','NSRP'),(14628,30907,'MBF transcription complex','C','A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.','2013-10-27','NSRP'),(14629,30908,'protein splicing','P','The post-translational removal of peptide sequences from within a protein sequence.','2013-10-27','NSRP'),(14630,30909,'non-intein-mediated protein splicing','P','The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins.','2013-10-27','NSRP'),(14631,30910,'olfactory placode formation','P','The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.','2013-10-27','NSRP'),(14632,30911,'TPR domain binding','F','Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices.','2013-10-27','NSRP'),(14633,30912,'response to deep water','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle.','2013-10-27','NSRP'),(14634,30913,'paranodal junction assembly','P','Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier.','2013-10-27','NSRP'),(14635,30914,'STAGA complex','C','A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs.','2013-10-27','NSRP'),(14636,30915,'Smc5-Smc6 complex','C','A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.','2013-10-27','NSRP'),(14637,30916,'otic vesicle formation','P','The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear.','2013-10-27','NSRP'),(14638,30917,'midbrain-hindbrain boundary development','P','The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.','2013-10-27','NSRP'),(14639,30919,'peptidyl-serine O-acetylation','P','The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine.','2013-10-27','NSRP'),(14640,30920,'peptidyl-serine acetylation','P','The acetylation of peptidyl-serine.','2013-10-27','NSRP'),(14641,30921,'peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine','P','The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues.','2013-10-27','NSRP'),(14642,30922,'peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine','P','The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues.','2013-10-27','NSRP'),(14643,30923,'metal incorporation into metallo-oxygen cluster','P','The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate.','2013-10-27','NSRP'),(14644,30924,'manganese incorporation into metallo-oxygen cluster','P','The incorporation of manganese into a metallo-oxygen cluster.','2013-10-27','NSRP'),(14645,30925,'calcium incorporation into metallo-oxygen cluster','P','The incorporation of calcium into a metallo-oxygen cluster.','2013-10-27','NSRP'),(14646,30926,'calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide','P','The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site.','2013-10-27','NSRP'),(14647,30927,'manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide','P','The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site.','2013-10-27','NSRP'),(14648,30929,'ADPG pyrophosphorylase complex','C','Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits.','2013-10-27','NSRP'),(14649,30930,'homotetrameric ADPG pyrophosphorylase complex','C','A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species.','2013-10-27','NSRP'),(14650,30931,'heterotetrameric ADPG pyrophosphorylase complex','C','A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus.','2013-10-27','NSRP'),(14651,30932,'amyloplast ADPG pyrophosphorylase complex','C','An ADPG pyrophosphorylase complex found in the amyloplast.','2013-10-27','NSRP'),(14652,30933,'chloroplast ADPG pyrophosphorylase complex','C','An ADPG pyrophosphorylase complex found in the chloroplast.','2013-10-27','NSRP'),(14653,30934,'anchoring collagen','C','Any collagen polymer which links one collagen assembly, such as a collagen fibril or sheet, to other structures.','2013-10-27','NSRP'),(14654,30935,'sheet-forming collagen','C','Any collagen polymer in which collagen triple helices associate to form sheet-like networks.','2013-10-27','NSRP'),(14655,30936,'transmembrane collagen','C','Any collagen polymer that passes through a lipid bilayer membrane.','2013-10-27','NSRP'),(14656,30937,'collagen type XVII','C','A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices associate with hemidesmosomes and the basal lamina.','2013-10-27','NSRP'),(14657,30938,'collagen type XVIII','C','A collagen homotrimer of alpha1(XVIII) chains.','2013-10-27','NSRP'),(14658,30939,'response to long-day photoperiod','P','OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark.','2013-10-27','NSRP'),(14659,30940,'response to short-day photoperiod','P','OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light.','2013-10-27','NSRP'),(14660,30941,'chloroplast targeting sequence binding','F','Interacting selectively and non-covalently with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.','2013-10-27','NSRP'),(14661,30942,'endoplasmic reticulum signal peptide binding','F','Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.','2013-10-27','NSRP'),(14662,30943,'mitochondrion targeting sequence binding','F','Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.','2013-10-27','NSRP'),(14663,30944,'DDEL sequence binding','F','Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.','2013-10-27','NSRP'),(14664,30945,'protein tyrosine phosphatase activity, via thiol-phosphate intermediate','F','The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate.','2013-10-27','NSRP'),(14665,30946,'protein tyrosine phosphatase activity, metal-dependent','F','Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions.','2013-10-27','NSRP'),(14666,30947,'regulation of vascular endothelial growth factor receptor signaling pathway','P','Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.','2013-10-27','NSRP'),(14667,30948,'negative regulation of vascular endothelial growth factor receptor signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.','2013-10-27','NSRP'),(14668,30949,'positive regulation of vascular endothelial growth factor receptor signaling pathway','P','Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.','2013-10-27','NSRP'),(14669,30950,'establishment or maintenance of actin cytoskeleton polarity','P','Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.','2013-10-27','NSRP'),(14670,30951,'establishment or maintenance of microtubule cytoskeleton polarity','P','Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.','2013-10-27','NSRP'),(14671,30952,'establishment or maintenance of cytoskeleton polarity','P','Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.','2013-10-27','NSRP'),(14672,30953,'astral microtubule organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.','2013-10-27','NSRP'),(14673,30954,'astral microtubule nucleation','P','The \'de novo\' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule.','2013-10-27','NSRP'),(14674,30955,'potassium ion binding','F','Interacting selectively and non-covalently with potassium (K+) ions.','2013-10-27','NSRP'),(14675,30956,'glutamyl-tRNA(Gln) amidotransferase complex','C','A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms.','2013-10-27','NSRP'),(14676,30957,'Tat protein binding','F','Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.','2013-10-27','NSRP'),(14677,30958,'RITS complex','C','A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing.','2013-10-27','NSRP'),(14678,30959,'peptide cross-linking via 3\'-(3\'-L-tyrosinyl)-L-tyrosine','P','The modification of two peptidyl-tyrosines to form a 3\'-(3\'-L-tyrosinyl)-L-tyrosine protein cross-link.','2013-10-27','NSRP'),(14679,30960,'peptide cross-linking via 3\'-(O4\'-L-tyrosinyl)-L-tyrosine','P','The modification of two peptidyl-tyrosines to form a 3\'-(O4\'-L-tyrosinyl)-L-tyrosine protein cross-link.','2013-10-27','NSRP'),(14680,30961,'peptidyl-arginine hydroxylation','P','The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine.','2013-10-27','NSRP'),(14681,30962,'peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine','P','The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine.','2013-10-27','NSRP'),(14682,30963,'peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine','P','The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine.','2013-10-27','NSRP'),(14683,30964,'NADH dehydrogenase complex','C','An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.','2013-10-27','NSRP'),(14684,30965,'plasma membrane electron transport, NADH to quinone','P','The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase.','2013-10-27','NSRP'),(14685,30967,'ER-nuclear sterol response pathway','P','The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of sterol depletion, and resulting in the activation of transcription by SREBP.','2012-03-14','NSRP'),(14686,30968,'endoplasmic reticulum unfolded protein response','P','The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.','2013-10-27','NSRP'),(14687,30969,'UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response','P','The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes.','2013-10-27','NSRP'),(14688,30970,'retrograde protein transport, ER to cytosol','P','The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.','2013-10-27','NSRP'),(14689,30971,'receptor tyrosine kinase binding','F','Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.','2013-10-27','NSRP'),(14690,30972,'cleavage of cytosolic proteins involved in execution phase of apoptosis','P','The proteolytic degradation of proteins in the cytosol that contributes to apoptosis.','2013-10-27','NSRP'),(14691,30973,'molybdate ion binding','F','Interacting selectively and non-covalently with molybdate (MoO4 2-) ions.','2013-10-27','NSRP'),(14692,30974,'thiamine pyrophosphate transport','P','The directed movement of thiamine pyrophosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(14693,30975,'thiamine binding','F','Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.','2013-10-27','NSRP'),(14694,30976,'thiamine pyrophosphate binding','F','Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.','2013-10-27','NSRP'),(14695,30977,'taurine binding','F','Interacting selectively and non-covalently with taurine.','2013-10-27','NSRP'),(14696,30978,'alpha-glucan metabolic process','P','The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds.','2013-10-27','NSRP'),(14697,30979,'alpha-glucan biosynthetic process','P','The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds.','2013-10-27','NSRP'),(14698,30980,'alpha-glucan catabolic process','P','The chemical reactions and pathways resulting in the breakdown of alpha-glucans.','2013-10-27','NSRP'),(14699,30981,'cortical microtubule cytoskeleton','C','The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane.','2013-10-27','NSRP'),(14700,30982,'adventurous gliding motility','P','A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime.','2013-10-27','NSRP'),(14701,30983,'mismatched DNA binding','F','Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches.','2013-10-27','NSRP'),(14702,30984,'kininogen binding','F','Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors.','2013-10-27','NSRP'),(14703,30985,'high molecular weight kininogen binding','F','Interacting selectively and non-covalently with a kininogen of high molecular mass.','2013-10-27','NSRP'),(14704,30986,'low molecular weight kininogen binding','F','Interacting selectively and non-covalently with a kininogen of low molecular mass.','2013-10-27','NSRP'),(14705,30987,'high molecular weight kininogen receptor binding','F','Interacting selectively and non-covalently with a high molecular weight kininogen receptor.','2013-10-27','NSRP'),(14706,30988,'high molecular weight kininogen receptor complex','C','A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins.','2013-10-27','NSRP'),(14707,30989,'dynein-driven meiotic oscillatory nuclear movement','P','The cell cycle process in which oscillatory movement of the nucleus during meiotic prophase I occurs. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein. It is known to play a central role in meiotic recombination and homologous chromosome pairing; as observed in S. pombe.','2013-10-27','NSRP'),(14708,30990,'intraflagellar transport particle','C','A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.','2013-10-27','NSRP'),(14709,30991,'intraflagellar transport particle A','C','The smaller subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights of 710-760 kDa.','2013-10-27','NSRP'),(14710,30992,'intraflagellar transport particle B','C','The larger subcomplex of the intraflagellar transport particle; characterized complexes have molecular weights around 550 kDa.','2013-10-27','NSRP'),(14711,30993,'axonemal heterotrimeric kinesin-II complex','C','A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme.','2013-10-27','NSRP'),(14712,30994,'primary cell septum disassembly','P','Dissolution of the primary septum during cell separation.','2013-10-27','NSRP'),(14713,30995,'cell septum edging catabolic process','P','The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation.','2013-10-27','NSRP'),(14714,30996,'cell cycle arrest in response to nitrogen starvation','P','The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen.','2013-10-27','NSRP'),(14715,30997,'regulation of centriole-centriole cohesion','P','Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker.','2013-10-27','NSRP'),(14716,30998,'linear element','C','A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex.','2013-10-27','NSRP'),(14717,30999,'linear element assembly','P','The cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase.','2013-10-27','NSRP'),(14718,31000,'response to caffeine','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.','2013-10-27','NSRP'),(14719,31001,'response to brefeldin A','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus.','2013-10-27','NSRP'),(14720,31002,'actin rod','C','A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum.','2013-10-27','NSRP'),(14721,31003,'actin tubule','C','A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together.','2013-10-27','NSRP'),(14722,31004,'potassium ion-transporting ATPase complex','C','Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex.','2013-10-27','NSRP'),(14723,31005,'filamin binding','F','Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.','2013-10-27','NSRP'),(14724,31006,'filamin-A binding','F','Interacting selectively and non-covalently with filamin-A.','2012-03-14','NSRP'),(14725,31007,'filamin-B binding','F','Interacting selectively and non-covalently with filamin-B.','2012-03-14','NSRP'),(14726,31008,'filamin-C binding','F','Interacting selectively and non-covalently with filamin-C, a filamin isoform that contains an 81 amino acid insertion in repeat 20, not present in filamin-A or -B.','2012-03-14','NSRP'),(14727,31009,'plastid ADPG pyrophosphorylase complex','C','An ADPG pyrophosphorylase complex found in a plastid.','2013-10-27','NSRP'),(14728,31010,'ISWI-type complex','C','Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair.','2013-10-27','NSRP'),(14729,31011,'Ino80 complex','C','A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3\' to 5\' DNA helicase activity.','2013-10-27','NSRP'),(14730,31012,'extracellular matrix','C','A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants).','2013-10-27','NSRP'),(14731,31013,'troponin I binding','F','Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex.','2013-10-27','NSRP'),(14732,31014,'troponin T binding','F','Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex.','2013-10-27','NSRP'),(14733,31015,'karyopherin docking complex','C','OBSOLETE. A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p.','2013-10-27','NSRP'),(14734,31016,'pancreas development','P','The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.','2013-10-27','NSRP'),(14735,31017,'exocrine pancreas development','P','The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.','2013-10-27','NSRP'),(14736,31018,'endocrine pancreas development','P','The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.','2013-10-27','NSRP'),(14737,31019,'mitochondrial mRNA editing complex','C','An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates.','2013-10-27','NSRP'),(14738,31020,'plastid mRNA editing complex','C','An mRNA editing complex found in a plastid.','2013-10-27','NSRP'),(14739,31021,'interphase microtubule organizing center','C','A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus.','2013-10-27','NSRP'),(14740,31022,'nuclear migration along microfilament','P','The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.','2013-10-27','NSRP'),(14741,31023,'microtubule organizing center organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.','2013-10-27','NSRP'),(14742,31024,'interphase microtubule organizing center assembly','P','The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center.','2013-10-27','NSRP'),(14743,31025,'equatorial microtubule organizing center disassembly','P','The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis.','2013-10-27','NSRP'),(14744,31026,'glutamate synthase complex','C','A complex that possesses glutamate synthase activity.','2013-10-27','NSRP'),(14745,31027,'glutamate synthase complex (NADH)','C','A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.','2013-10-27','NSRP'),(14746,31028,'septation initiation signaling cascade','P','The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis.','2013-10-27','NSRP'),(14747,31029,'regulation of septation initiation signaling cascade','P','Any process that modulates the frequency, rate or extent of septation initiation signaling.','2013-10-27','NSRP'),(14748,31030,'negative regulation of septation initiation signaling cascade','P','Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling.','2013-10-27','NSRP'),(14749,31031,'positive regulation of septation initiation signaling cascade','P','Any process that activates or increases the frequency, rate or extent of septation initiation signaling.','2013-10-27','NSRP'),(14750,31032,'actomyosin structure organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.','2013-10-27','NSRP'),(14751,31033,'myosin filament organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules.','2013-10-27','NSRP'),(14752,31034,'myosin filament assembly','P','The aggregation, arrangement and bonding together of a filament composed of myosin molecules.','2013-10-27','NSRP'),(14753,31035,'myosin filament disassembly','P','The disassembly of a filament composed of myosin molecules.','2013-10-27','NSRP'),(14754,31036,'myosin II filament assembly','P','The formation of a bipolar filament composed of myosin II molecules.','2013-10-27','NSRP'),(14755,31037,'myosin II filament disassembly','P','The disassembly of a bipolar filament composed of myosin II molecules.','2013-10-27','NSRP'),(14756,31038,'myosin II filament organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules.','2013-10-27','NSRP'),(14757,31039,'macronucleus','C','A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell\'s complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell.','2013-10-27','NSRP'),(14758,31040,'micronucleus','C','A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell\'s complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell.','2013-10-27','NSRP'),(14759,31041,'O-glycan processing, core 5','P','The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc.','2013-10-27','NSRP'),(14760,31042,'O-glycan processing, core 6','P','The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc.','2013-10-27','NSRP'),(14761,31043,'O-glycan processing, core 7','P','The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc.','2013-10-27','NSRP'),(14762,31044,'O-glycan processing, core 8','P','The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc.','2013-10-27','NSRP'),(14763,31045,'dense core granule','C','Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.','2013-10-27','NSRP'),(14764,31046,'spindle pole body duplication in cytoplasm','P','Construction of a new spindle pole body adjacent to the existing spindle pole body exterior to the outer nuclear envelope.','2013-10-27','NSRP'),(14765,31047,'gene silencing by RNA','P','Any process in which RNA molecules inactivate expression of target genes.','2013-10-27','NSRP'),(14766,31048,'chromatin silencing by small RNA','P','Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region.','2013-10-27','NSRP'),(14767,31049,'programmed DNA elimination','P','The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate.','2013-10-27','NSRP'),(14768,31050,'dsRNA fragmentation','P','Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function.','2013-10-27','NSRP'),(14769,31051,'scnRNA production','P','Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome.','2013-10-27','NSRP'),(14770,31052,'chromosome breakage','P','Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.','2013-10-27','NSRP'),(14771,31053,'primary miRNA processing','P','Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule.','2013-10-27','NSRP'),(14772,31054,'pre-miRNA processing','P','Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule.','2013-10-27','NSRP'),(14773,31055,'chromatin remodeling at centromere','P','Dynamic structural changes in centromeric DNA.','2013-10-27','NSRP'),(14774,31056,'regulation of histone modification','P','Any process that modulates the frequency, rate or extent of the covalent alteration of a histone.','2013-10-27','NSRP'),(14775,31057,'negative regulation of histone modification','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone.','2013-10-27','NSRP'),(14776,31058,'positive regulation of histone modification','P','Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone.','2013-10-27','NSRP'),(14777,31059,'histone deacetylation at centromere','P','The removal of acetyl groups from histones in centromeric DNA.','2013-10-27','NSRP'),(14778,31060,'regulation of histone methylation','P','Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones.','2013-10-27','NSRP'),(14779,31061,'negative regulation of histone methylation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones.','2013-10-27','NSRP'),(14780,31062,'positive regulation of histone methylation','P','Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones.','2013-10-27','NSRP'),(14781,31063,'regulation of histone deacetylation','P','Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones.','2013-10-27','NSRP'),(14782,31064,'negative regulation of histone deacetylation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.','2013-10-27','NSRP'),(14783,31065,'positive regulation of histone deacetylation','P','Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.','2013-10-27','NSRP'),(14784,31066,'regulation of histone deacetylation at centromere','P','Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA.','2013-10-27','NSRP'),(14785,31067,'negative regulation of histone deacetylation at centromere','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA.','2013-10-27','NSRP'),(14786,31068,'positive regulation of histone deacetylation at centromere','P','Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA.','2013-10-27','NSRP'),(14787,31069,'hair follicle morphogenesis','P','The process in which the anatomical structures of the hair follicle are generated and organized.','2013-10-27','NSRP'),(14788,31070,'intronic snoRNA processing','P','The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA.','2013-10-27','NSRP'),(14789,31071,'cysteine desulfurase activity','F','Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine.','2013-10-27','NSRP'),(14790,31072,'heat shock protein binding','F','Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.','2013-10-27','NSRP'),(14791,31073,'cholesterol 26-hydroxylase activity','F','Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.','2013-10-27','NSRP'),(14792,31074,'nucleocytoplasmic shuttling complex','C','Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores.','2013-10-27','NSRP'),(14793,31076,'embryonic camera-type eye development','P','The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.','2013-10-27','NSRP'),(14794,31077,'post-embryonic camera-type eye development','P','The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure.','2013-10-27','NSRP'),(14795,31078,'histone deacetylase activity (H3-K14 specific)','F','Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.','2013-10-27','NSRP'),(14796,31079,'picornain 3C activity','F','OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.','2013-10-27','NSRP'),(14797,31080,'nuclear pore outer ring','C','A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical \'spokes\' around the central transport channel. A single \'spoke\', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).','2013-10-27','NSRP'),(14798,31081,'nuclear pore distribution','P','Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope.','2013-10-27','NSRP'),(14799,31082,'BLOC complex','C','Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex.','2013-10-27','NSRP'),(14800,31083,'BLOC-1 complex','C','A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.','2013-10-27','NSRP'),(14801,31084,'BLOC-2 complex','C','A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru.','2013-10-27','NSRP'),(14802,31085,'BLOC-3 complex','C','A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins.','2013-10-27','NSRP'),(14803,31086,'nuclear-transcribed mRNA catabolic process, deadenylation-independent decay','P','A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability.','2013-10-27','NSRP'),(14804,31087,'deadenylation-independent decapping of nuclear-transcribed mRNA','P','Cleavage of the 5\'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening.','2013-10-27','NSRP'),(14805,31088,'platelet dense granule membrane','C','The lipid bilayer surrounding the platelet dense granule.','2013-10-27','NSRP'),(14806,31089,'platelet dense granule lumen','C','The volume enclosed by the membrane of the platelet dense granule.','2013-10-27','NSRP'),(14807,31090,'organelle membrane','C','The lipid bilayer surrounding an organelle.','2013-10-27','NSRP'),(14808,31091,'platelet alpha granule','C','A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).','2013-10-27','NSRP'),(14809,31092,'platelet alpha granule membrane','C','The lipid bilayer surrounding the platelet alpha granule.','2013-10-27','NSRP'),(14810,31093,'platelet alpha granule lumen','C','The volume enclosed by the membrane of the platelet alpha granule.','2013-10-27','NSRP'),(14811,31094,'platelet dense tubular network','C','A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin.','2013-10-27','NSRP'),(14812,31095,'platelet dense tubular network membrane','C','The lipid bilayer surrounding the platelet dense tubular network.','2013-10-27','NSRP'),(14813,31096,'platelet dense tubular network lumen','C','The volume enclosed by the membranes of the platelet dense tubular network.','2013-10-27','NSRP'),(14814,31097,'medial cortex','C','A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation.','2013-10-27','NSRP'),(14815,31098,'stress-activated protein kinase signaling cascade','P','A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.','2013-10-27','NSRP'),(14816,31099,'regeneration','P','The regrowth of a lost or destroyed body part, such as an organ or tissue.','2013-10-27','NSRP'),(14817,31100,'organ regeneration','P','The regrowth of a lost or destroyed organ.','2013-10-27','NSRP'),(14818,31101,'fin regeneration','P','The regrowth of fin tissue following its loss or destruction.','2013-10-27','NSRP'),(14819,31102,'neuron projection regeneration','P','The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.','2013-10-27','NSRP'),(14820,31103,'axon regeneration','P','The regrowth of axons following their loss or damage.','2013-10-27','NSRP'),(14821,31104,'dendrite regeneration','P','The regrowth of dendrites in response to their loss or damage.','2013-10-27','NSRP'),(14822,31105,'septin complex','C','Any of several heterooligomeric complexes containing multiple septins.','2013-10-27','NSRP'),(14823,31106,'septin ring organization','P','Control of the formation, spatial distribution, and breakdown of the septin ring.','2013-10-27','NSRP'),(14824,31107,'septin ring disassembly','P','The controlled breakdown of a septin ring.','2013-10-27','NSRP'),(14825,31108,'holo-[acyl-carrier-protein] biosynthetic process','P','The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein].','2013-10-27','NSRP'),(14826,31109,'microtubule polymerization or depolymerization','P','Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.','2013-10-27','NSRP'),(14827,31110,'regulation of microtubule polymerization or depolymerization','P','Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.','2013-10-27','NSRP'),(14828,31111,'negative regulation of microtubule polymerization or depolymerization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.','2013-10-27','NSRP'),(14829,31112,'positive regulation of microtubule polymerization or depolymerization','P','Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization.','2013-10-27','NSRP'),(14830,31113,'regulation of microtubule polymerization','P','Any process that modulates the frequency, rate or extent of microtubule polymerization.','2013-10-27','NSRP'),(14831,31114,'regulation of microtubule depolymerization','P','Any process that modulates the frequency, rate or extent of microtubule depolymerization.','2013-10-27','NSRP'),(14832,31115,'negative regulation of microtubule polymerization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.','2013-10-27','NSRP'),(14833,31116,'positive regulation of microtubule polymerization','P','Any process that activates or increases the frequency, rate or extent of microtubule polymerization.','2013-10-27','NSRP'),(14834,31117,'positive regulation of microtubule depolymerization','P','Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.','2013-10-27','NSRP'),(14835,31118,'rRNA pseudouridine synthesis','P','The intramolecular conversion of uridine to pseudouridine in an rRNA molecule.','2013-10-27','NSRP'),(14836,31119,'tRNA pseudouridine synthesis','P','The intramolecular conversion of uridine to pseudouridine in a tRNA molecule.','2013-10-27','NSRP'),(14837,31120,'snRNA pseudouridine synthesis','P','The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.','2013-10-27','NSRP'),(14838,31121,'equatorial microtubule organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell.','2013-10-27','NSRP'),(14839,31122,'cytoplasmic microtubule organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.','2013-10-27','NSRP'),(14840,31123,'RNA 3\'-end processing','P','Any process involved in forming the mature 3\' end of an RNA molecule.','2013-10-27','NSRP'),(14841,31124,'mRNA 3\'-end processing','P','Any process involved in forming the mature 3\' end of an mRNA molecule.','2013-10-27','NSRP'),(14842,31125,'rRNA 3\'-end processing','P','Any process involved in forming the mature 3\' end of an rRNA molecule.','2013-10-27','NSRP'),(14843,31126,'snoRNA 3\'-end processing','P','Any process involved in forming the mature 3\' end of a snoRNA molecule.','2013-10-27','NSRP'),(14844,31127,'alpha-(1,2)-fucosyltransferase activity','F','Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage.','2013-10-27','NSRP'),(14845,31128,'developmental induction','P','Signaling at short range between cells or tissues of different ancestry and developmental potential that results in one cell or tissue effecting a developmental change in the other.','2013-10-27','NSRP'),(14846,31129,'inductive cell-cell signaling','P','Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate.','2013-10-27','NSRP'),(14847,31130,'creation of an inductive signal','P','The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter.','2013-10-27','NSRP'),(14848,31131,'reception of an inductive signal','P','The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change.','2013-10-27','NSRP'),(14849,31132,'serine 3-dehydrogenase activity','F','Catalysis of the reaction: L-serine + NADP(+) = L-alpha-formylglycine + 2 H(+) + NADPH.','2013-10-27','NSRP'),(14850,31133,'regulation of axon diameter','P','Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained.','2013-10-27','NSRP'),(14851,31134,'sister chromatid biorientation','P','The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles.','2013-10-27','NSRP'),(14852,31135,'negative regulation of conjugation','P','Any process that decreases the rate of conjugation.','2013-10-27','NSRP'),(14853,31136,'positive regulation of conjugation','P','Any process that increases the rate or frequency of conjugation.','2013-10-27','NSRP'),(14854,31137,'regulation of conjugation with cellular fusion','P','Any process that modulates the rate or frequency of conjugation with cellular fusion.','2013-10-27','NSRP'),(14855,31138,'negative regulation of conjugation with cellular fusion','P','Any process that decreases the rate or frequency of conjugation with cellular fusion.','2013-10-27','NSRP'),(14856,31139,'positive regulation of conjugation with cellular fusion','P','Any process that increases the rate or frequency of conjugation with cellular fusion.','2013-10-27','NSRP'),(14857,31140,'induction of conjugation upon nutrient starvation','P','The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients.','2013-10-27','NSRP'),(14858,31141,'induction of conjugation upon carbon starvation','P','The process in which a cell initiates conjugation with cellular fusion upon carbon starvation.','2013-10-27','NSRP'),(14859,31142,'induction of conjugation upon nitrogen starvation','P','The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation.','2013-10-27','NSRP'),(14860,31143,'pseudopodium','C','A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.','2013-10-27','NSRP'),(14861,31144,'proteasome localization','P','Any process in which the proteasome is transported to, or maintained in, a specific location.','2013-10-27','NSRP'),(14862,31145,'anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.','2013-10-27','NSRP'),(14863,31146,'SCF-dependent proteasomal ubiquitin-dependent protein catabolic process','P','The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.','2013-10-27','NSRP'),(14864,31147,'1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process','P','The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells.','2013-10-27','NSRP'),(14865,31148,'DIF-1 biosynthetic process','P','The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells.','2013-10-27','NSRP'),(14866,31149,'sorocarp stalk cell differentiation','P','The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum.','2013-10-27','NSRP'),(14867,31150,'sorocarp stalk development','P','The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.','2013-10-27','NSRP'),(14868,31151,'histone methyltransferase activity (H3-K79 specific)','F','Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein.','2013-10-27','NSRP'),(14869,31152,'aggregation involved in sorocarp development','P','The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.','2013-10-27','NSRP'),(14870,31153,'slug development involved in sorocarp development','P','The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development.','2013-10-27','NSRP'),(14871,31154,'culmination involved in sorocarp development','P','The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.','2013-10-27','NSRP'),(14872,31155,'regulation of fruiting body development','P','Any process that modulates the frequency, rate or extent of fruiting body development.','2013-10-27','NSRP'),(14873,31156,'regulation of sorocarp development','P','Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum.','2013-10-27','NSRP'),(14874,31157,'regulation of aggregate size involved in sorocarp development','P','Any process that modulates the size of the aggregate formed during sorocarp formation.','2013-10-27','NSRP'),(14875,31158,'negative regulation of aggregate size involved in sorocarp development','P','Any process that decreases the size of the aggregate formed during sorocarp formation.','2013-10-27','NSRP'),(14876,31159,'positive regulation of aggregate size involved in sorocarp development','P','Any process that increases the size of the aggregate formed during sorocarp formation.','2013-10-27','NSRP'),(14877,31160,'spore wall','C','The specialized envelope lying outside the cell membrane of a spore.','2013-10-27','NSRP'),(14878,31161,'phosphatidylinositol catabolic process','P','The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.','2013-10-27','NSRP'),(14879,31162,'sulfur incorporation into metallo-sulfur cluster','P','The incorporation of exogenous sulfur into a metallo-sulfur cluster.','2013-10-27','NSRP'),(14880,31163,'metallo-sulfur cluster assembly','P','The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster.','2013-10-27','NSRP'),(14881,31164,'contractile vacuolar membrane','C','The lipid bilayer surrounding the contractile vacuole.','2013-10-27','NSRP'),(14882,31165,'integral to contractile vacuolar membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the contractile vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(14883,31166,'integral to vacuolar membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the vacuolar membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(14884,31167,'rRNA methylation','P','The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule.','2013-10-27','NSRP'),(14885,31168,'ferrichrome metabolic process','P','The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N\'acyl-N4-hydroxy-L-ornithine.','2013-10-27','NSRP'),(14886,31169,'ferrichrome biosynthetic process','P','The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N\'acyl-N4-hydroxy-L-ornithine.','2013-10-27','NSRP'),(14887,31170,'ferricrocin metabolic process','P','The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3.','2013-10-27','NSRP'),(14888,31171,'ferricrocin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3.','2013-10-27','NSRP'),(14889,31172,'ornithine N5-monooxygenase activity','F','Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O.','2013-10-27','NSRP'),(14890,31173,'otolith mineralization completed early in development','P','The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear.','2013-10-27','NSRP'),(14891,31174,'lifelong otolith mineralization','P','The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added.','2013-10-27','NSRP'),(14892,31175,'neuron projection development','P','The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).','2013-10-27','NSRP'),(14893,31176,'endo-1,4-beta-xylanase activity','F','Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.','2013-10-27','NSRP'),(14894,31177,'phosphopantetheine binding','F','Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4\'-(dihydrogen phosphate).','2013-10-27','NSRP'),(14895,31179,'peptide modification','P','The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide.','2013-10-27','NSRP'),(14896,31201,'SNARE complex','C','A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.','2013-10-27','NSRP'),(14897,31203,'posttranslational protein targeting to membrane, docking','P','The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex.','2013-10-27','NSRP'),(14898,31204,'posttranslational protein targeting to membrane, translocation','P','The process in which a protein translocates through the ER membrane posttranslationally.','2013-10-27','NSRP'),(14899,31205,'endoplasmic reticulum Sec complex','C','An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex.','2013-10-27','NSRP'),(14900,31207,'Sec62/Sec63 complex','C','A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.','2013-10-27','NSRP'),(14901,31208,'POZ domain binding','F','Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.','2013-10-27','NSRP'),(14902,31209,'SCAR complex','C','A heterotetrameric complex that includes orthologues of human PIR121, Nap125 and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.','2013-10-27','NSRP'),(14903,31210,'phosphatidylcholine binding','F','Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline.','2013-10-27','NSRP'),(14904,31211,'endoplasmic reticulum palmitoyltransferase complex','C','A dimeric complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue.','2013-10-27','NSRP'),(14905,31213,'RSF complex','C','An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters).','2013-10-27','NSRP'),(14906,31214,'biomineral tissue development','P','Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.','2013-10-27','NSRP'),(14907,31215,'shell calcification','P','The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell.','2013-10-27','NSRP'),(14908,31216,'neopullulanase activity','F','Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose).','2013-10-27','NSRP'),(14909,31217,'glucan 1,4-beta-glucosidase activity','F','Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units.','2013-10-27','NSRP'),(14910,31218,'arabinogalactan endo-1,4-beta-galactosidase activity','F','Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans.','2013-10-27','NSRP'),(14911,31219,'levanase activity','F','Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units.','2013-10-27','NSRP'),(14912,31220,'maltodextrin phosphorylase activity','F','Catalysis of the reaction: maltodextrin = glucose-1-phosphate.','2013-10-27','NSRP'),(14913,31221,'arabinan metabolic process','P','The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues.','2013-10-27','NSRP'),(14914,31222,'arabinan catabolic process','P','The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues.','2013-10-27','NSRP'),(14915,31223,'auditory behavior','P','The behavior of an organism in response to a sound.','2013-10-27','NSRP'),(14916,31224,'intrinsic to membrane','C','Located in a membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14917,31225,'anchored to membrane','C','Tethered to a membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane. When used to describe a protein, indicates that none of the peptide sequence is embedded in the membrane.','2013-10-27','NSRP'),(14918,31226,'intrinsic to plasma membrane','C','Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14919,31227,'intrinsic to endoplasmic reticulum membrane','C','Located in the endoplasmic reticulum membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14920,31228,'intrinsic to Golgi membrane','C','Located in the Golgi membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14921,31229,'intrinsic to nuclear inner membrane','C','Located in the nuclear inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14922,31230,'intrinsic to cell outer membrane','C','Located in the cell outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14923,31231,'intrinsic to peroxisomal membrane','C','Located in the peroxisomal membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14924,31232,'extrinsic to external side of plasma membrane','C','Loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(14925,31233,'intrinsic to external side of plasma membrane','C','Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side (leaflet) opposite to the side that faces the cytoplasm.','2013-10-27','NSRP'),(14926,31234,'extrinsic to internal side of plasma membrane','C','Loosely bound to the surface of the plasma membrane that faces the cytoplasm, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(14927,31235,'intrinsic to internal side of plasma membrane','C','Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side (leaflet) that faces the cytoplasm.','2013-10-27','NSRP'),(14928,31236,'extrinsic to external side of plasma membrane, in periplasmic space','C','Located in the periplasmic space and loosely bound to the surface of the plasma membrane that faces away from the cytoplasm, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(14929,31237,'intrinsic to external side of plasma membrane, in periplasmic space','C','Located in the plasma membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located in the periplasmic space.','2013-10-27','NSRP'),(14930,31240,'external side of cell outer membrane','C','The side of the outer membrane that is opposite to the side that faces the periplasm of the cell.','2013-10-27','NSRP'),(14931,31241,'internal side of cell outer membrane','C','The side (leaflet) of the outer membrane that faces the periplasm of the cell.','2013-10-27','NSRP'),(14932,31242,'extrinsic to external side of cell outer membrane','C','Loosely bound to the surface of the outer membrane of the cell that faces away from the cytoplasm, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(14933,31243,'intrinsic to external side of cell outer membrane','C','Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side (leaflet) opposite to the side that faces the periplasm.','2013-10-27','NSRP'),(14934,31244,'extrinsic to cell outer membrane','C','Loosely bound to one surface of the outer membrane of the cell, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(14935,31245,'extrinsic to internal side of cell outer membrane','C','Loosely bound to the surface of the outer membrane of the cell that faces the cytoplasm, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(14936,31246,'intrinsic to internal side of cell outer membrane','C','Located in the outer membrane of the cell such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane, with the bulk of the gene product located on the side (leaflet) that faces the periplasm.','2013-10-27','NSRP'),(14937,31247,'actin rod assembly','P','The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.','2013-10-27','NSRP'),(14938,31248,'protein acetyltransferase complex','C','A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule.','2013-10-27','NSRP'),(14939,31249,'denatured protein binding','F','Interacting selectively and non-covalently with denatured proteins.','2013-10-27','NSRP'),(14940,31250,'anaerobic ribonucleoside-triphosphate reductase complex','C','An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2\'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit.','2013-10-27','NSRP'),(14941,31251,'PAN complex','C','A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.','2013-10-27','NSRP'),(14942,31252,'cell leading edge','C','The area of a motile cell closest to the direction of movement.','2013-10-27','NSRP'),(14943,31253,'cell projection membrane','C','The portion of the plasma membrane surrounding a cell surface projection.','2013-10-27','NSRP'),(14944,31254,'trailing edge','C','The area of a motile cell opposite to the direction of movement.','2013-10-27','NSRP'),(14945,31255,'lateral part of motile cell','C','The area of a motile cell perpendicular to the direction of movement.','2013-10-27','NSRP'),(14946,31256,'leading edge membrane','C','The portion of the plasma membrane surrounding the leading edge of a motile cell.','2013-10-27','NSRP'),(14947,31257,'trailing edge membrane','C','The portion of the plasma membrane surrounding the trailing edge of a motile cell.','2013-10-27','NSRP'),(14948,31258,'lamellipodium membrane','C','The portion of the plasma membrane surrounding a lamellipodium.','2013-10-27','NSRP'),(14949,31259,'uropod membrane','C','The portion of the plasma membrane surrounding a uropod.','2013-10-27','NSRP'),(14950,31260,'pseudopodium membrane','C','The portion of the plasma membrane surrounding a pseudopodium.','2013-10-27','NSRP'),(14951,31261,'DNA replication preinitiation complex','C','A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.','2013-10-27','NSRP'),(14952,31262,'Ndc80 complex','C','A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore.','2013-10-27','NSRP'),(14953,31263,'amine-transporting ATPase activity','F','Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in).','2013-10-27','NSRP'),(14954,31264,'death-inducing signaling complex','C','A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor.','2013-10-27','NSRP'),(14955,31265,'CD95 death-inducing signaling complex','C','A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor.','2013-10-27','NSRP'),(14956,31266,'TRAIL death-inducing signaling complex','C','A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor.','2013-10-27','NSRP'),(14957,31267,'small GTPase binding','F','Interacting selectively and non-covalently with a small monomeric GTPase.','2013-10-27','NSRP'),(14958,31268,'pseudopodium organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.','2013-10-27','NSRP'),(14959,31269,'pseudopodium assembly','P','The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane.','2013-10-27','NSRP'),(14960,31270,'pseudopodium retraction','P','The myosin-based contraction and retraction of the pseudopodium.','2013-10-27','NSRP'),(14961,31271,'lateral pseudopodium assembly','P','The extension of a pseudopodium from the lateral area of a cell.','2013-10-27','NSRP'),(14962,31272,'regulation of pseudopodium assembly','P','Any process that modulates the frequency, rate or extent of the assembly of pseudopodia.','2013-10-27','NSRP'),(14963,31273,'negative regulation of pseudopodium assembly','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia.','2013-10-27','NSRP'),(14964,31274,'positive regulation of pseudopodium assembly','P','Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.','2013-10-27','NSRP'),(14965,31275,'regulation of lateral pseudopodium assembly','P','Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.','2013-10-27','NSRP'),(14966,31276,'negative regulation of lateral pseudopodium assembly','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.','2013-10-27','NSRP'),(14967,31277,'positive regulation of lateral pseudopodium assembly','P','Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.','2013-10-27','NSRP'),(14968,31278,'alpha-1,2-galactosyltransferase activity','F','Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage.','2013-10-27','NSRP'),(14969,31279,'regulation of cyclase activity','P','Any process that modulates the frequency, rate or extent of cyclase activity.','2013-10-27','NSRP'),(14970,31280,'negative regulation of cyclase activity','P','Any process that stops or reduces the activity of a cyclase.','2013-10-27','NSRP'),(14971,31281,'positive regulation of cyclase activity','P','Any process that activates or increases the activity of a cyclase.','2013-10-27','NSRP'),(14972,31282,'regulation of guanylate cyclase activity','P','Any process that modulates the frequency, rate or extent of guanylate cyclase activity.','2013-10-27','NSRP'),(14973,31283,'negative regulation of guanylate cyclase activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity.','2013-10-27','NSRP'),(14974,31284,'positive regulation of guanylate cyclase activity','P','Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.','2013-10-27','NSRP'),(14975,31285,'regulation of sorocarp stalk cell differentiation','P','Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.','2013-10-27','NSRP'),(14976,31286,'negative regulation of sorocarp stalk cell differentiation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.','2013-10-27','NSRP'),(14977,31287,'positive regulation of sorocarp stalk cell differentiation','P','Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.','2013-10-27','NSRP'),(14978,31288,'sorocarp morphogenesis','P','The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum.','2013-10-27','NSRP'),(14979,31289,'actin phosphorylation','P','The transfer of one or more phosphate groups to an actin molecule.','2013-10-27','NSRP'),(14980,31290,'retinal ganglion cell axon guidance','P','The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.','2013-10-27','NSRP'),(14981,31291,'Ran protein signal transduction','P','A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state.','2013-10-27','NSRP'),(14982,31292,'gene conversion at mating-type locus, DNA double-strand break processing','P','The 5\' to 3\' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3\' single-strand DNA overhang.','2013-10-27','NSRP'),(14983,31293,'membrane protein intracellular domain proteolysis','P','The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.','2013-10-27','NSRP'),(14984,31294,'lymphocyte costimulation','P','The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation.','2013-10-27','NSRP'),(14985,31295,'T cell costimulation','P','The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.','2013-10-27','NSRP'),(14986,31296,'B cell costimulation','P','The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.','2013-10-27','NSRP'),(14987,31297,'replication fork processing','P','The process in which a DNA replication fork that has stalled (due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes) is repaired and replication is restarted.','2013-10-27','NSRP'),(14988,31298,'replication fork protection complex','C','A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.','2013-10-27','NSRP'),(14989,31299,'taurine-pyruvate aminotransferase activity','F','Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde.','2013-10-27','NSRP'),(14990,31300,'intrinsic to organelle membrane','C','Located in an organelle membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14991,31301,'integral to organelle membrane','C','Penetrating at least one phospholipid bilayer of an organelle membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(14992,31302,'intrinsic to endosome membrane','C','Located in the endosome membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14993,31303,'integral to endosome membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the endosome membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(14994,31304,'intrinsic to mitochondrial inner membrane','C','Located in the mitochondrial inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14995,31305,'integral to mitochondrial inner membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(14996,31306,'intrinsic to mitochondrial outer membrane','C','Located in the mitochondrial outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14997,31307,'integral to mitochondrial outer membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the mitochondrial outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(14998,31308,'intrinsic to nuclear outer membrane','C','Located in the nuclear outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(14999,31309,'integral to nuclear outer membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(15000,31310,'intrinsic to vacuolar membrane','C','Located in the vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(15001,31311,'intrinsic to contractile vacuolar membrane','C','Located in the contractile vacuolar membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(15002,31312,'extrinsic to organelle membrane','C','Loosely bound to one surface of an organelle membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(15003,31313,'extrinsic to endosome membrane','C','Loosely bound to one surface of the endosome membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(15004,31314,'extrinsic to mitochondrial inner membrane','C','Loosely bound to one surface of the mitochondrial inner membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(15005,31315,'extrinsic to mitochondrial outer membrane','C','Loosely bound to one surface of the mitochondrial outer membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(15006,31316,'extrinsic to nuclear outer membrane','C','Loosely bound to one surface of the nuclear outer membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(15007,31317,'tripartite ATP-independent periplasmic transporter complex','C','A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients.','2013-10-27','NSRP'),(15008,31318,'detection of folic acid','P','The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal.','2013-10-27','NSRP'),(15009,31319,'detection of cAMP','P','The series of events in which a cAMP (cyclic AMP, adenosine 3\',5\'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP.','2013-10-27','NSRP'),(15010,31320,'hexitol dehydrogenase activity','F','Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor.','2013-10-27','NSRP'),(15011,31321,'ascospore-type prospore assembly','P','During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane.','2013-10-27','NSRP'),(15012,31322,'ascospore-type prospore-specific spindle pole body remodeling','P','A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP).','2013-10-27','NSRP'),(15013,31323,'regulation of cellular metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.','2013-10-27','NSRP'),(15014,31324,'negative regulation of cellular metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.','2013-10-27','NSRP'),(15015,31325,'positive regulation of cellular metabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.','2013-10-27','NSRP'),(15016,31326,'regulation of cellular biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.','2013-10-27','NSRP'),(15017,31327,'negative regulation of cellular biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.','2013-10-27','NSRP'),(15018,31328,'positive regulation of cellular biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.','2013-10-27','NSRP'),(15019,31329,'regulation of cellular catabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.','2013-10-27','NSRP'),(15020,31330,'negative regulation of cellular catabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.','2013-10-27','NSRP'),(15021,31331,'positive regulation of cellular catabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.','2013-10-27','NSRP'),(15022,31332,'RNAi effector complex','C','Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins.','2013-10-27','NSRP'),(15023,31333,'negative regulation of protein complex assembly','P','Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.','2013-10-27','NSRP'),(15024,31334,'positive regulation of protein complex assembly','P','Any process that activates or increases the frequency, rate or extent of protein complex assembly.','2013-10-27','NSRP'),(15025,31335,'regulation of sulfur amino acid metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.','2013-10-27','NSRP'),(15026,31336,'negative regulation of sulfur amino acid metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.','2013-10-27','NSRP'),(15027,31337,'positive regulation of sulfur amino acid metabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.','2013-10-27','NSRP'),(15028,31338,'regulation of vesicle fusion','P','Any process that modulates the frequency, rate or extent of vesicle fusion.','2013-10-27','NSRP'),(15029,31339,'negative regulation of vesicle fusion','P','Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion.','2013-10-27','NSRP'),(15030,31340,'positive regulation of vesicle fusion','P','Any process that activates or increases the frequency, rate or extent of vesicle fusion.','2013-10-27','NSRP'),(15031,31341,'regulation of cell killing','P','Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.','2013-10-27','NSRP'),(15032,31342,'negative regulation of cell killing','P','Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing.','2013-10-27','NSRP'),(15033,31343,'positive regulation of cell killing','P','Any process that activates or increases the frequency, rate or extent of cell killing.','2013-10-27','NSRP'),(15034,31344,'regulation of cell projection organization','P','Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.','2013-10-27','NSRP'),(15035,31345,'negative regulation of cell projection organization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.','2013-10-27','NSRP'),(15036,31346,'positive regulation of cell projection organization','P','Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.','2013-10-27','NSRP'),(15037,31347,'regulation of defense response','P','Any process that modulates the frequency, rate or extent of a defense response.','2013-10-27','NSRP'),(15038,31348,'negative regulation of defense response','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response.','2013-10-27','NSRP'),(15039,31349,'positive regulation of defense response','P','Any process that activates or increases the frequency, rate or extent of a defense response.','2013-10-27','NSRP'),(15040,31350,'intrinsic to plastid membrane','C','Located in a plastid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(15041,31351,'integral to plastid membrane','C','Penetrating at least one phospholipid bilayer of a plastid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(15042,31352,'intrinsic to plastid inner membrane','C','Located in a plastid inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(15043,31353,'integral to plastid inner membrane','C','Penetrating at least one phospholipid bilayer of a plastid inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(15044,31354,'intrinsic to plastid outer membrane','C','Located in a plastid outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(15045,31355,'integral to plastid outer membrane','C','Penetrating at least one phospholipid bilayer of a plastid outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(15046,31356,'intrinsic to chloroplast inner membrane','C','Located in the chloroplast inner membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(15047,31357,'integral to chloroplast inner membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(15048,31358,'intrinsic to chloroplast outer membrane','C','Located in the chloroplast outer membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(15049,31359,'integral to chloroplast outer membrane','C','Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the chloroplast outer membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(15050,31360,'intrinsic to thylakoid membrane','C','Located in a thylakoid membrane such that some covalently attached portion of the gene product, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, spans or is embedded in one or both leaflets of the membrane.','2013-10-27','NSRP'),(15051,31361,'integral to thylakoid membrane','C','Penetrating at least one phospholipid bilayer of a thylakoid membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.','2013-10-27','NSRP'),(15052,31362,'anchored to external side of plasma membrane','C','Tethered to the plasma membrane by a covalently attached anchor, such as a lipid group, that is embedded in the membrane, with the bulk of the gene product located in the side (leaflet) opposite to the side that faces the cytoplasm. When used to describe a protein, indicates that the peptide sequence does not span the membrane.','2013-10-27','NSRP'),(15053,31363,'N-terminal protein amino acid deamination','P','The removal of an amino group from the N-terminal amino acid residue of a protein.','2013-10-27','NSRP'),(15054,31364,'N-terminal protein amino acid deamination, from side chain','P','The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein.','2013-10-27','NSRP'),(15055,31365,'N-terminal protein amino acid modification','P','The alteration of the N-terminal amino acid residue in a protein.','2013-10-27','NSRP'),(15056,31366,'N-terminal peptidyl-asparagine deamination','P','The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein.','2013-10-27','NSRP'),(15057,31367,'N-terminal peptidyl-glutamine deamination','P','The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein.','2013-10-27','NSRP'),(15058,31368,'Pro-X metallocarboxypeptidase activity','F','OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid.','2013-10-27','NSRP'),(15059,31369,'translation initiation factor binding','F','Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.','2013-10-27','NSRP'),(15060,31370,'eukaryotic initiation factor 4G binding','F','Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.','2013-10-27','NSRP'),(15061,31371,'ubiquitin conjugating enzyme complex','C','Any complex that possesses ubiquitin conjugating enzyme activity.','2013-10-27','NSRP'),(15062,31372,'UBC13-MMS2 complex','C','A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p.','2013-10-27','NSRP'),(15063,31375,'type II fatty acid synthase complex','C','OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity.','2013-10-27','NSRP'),(15064,31376,'cytosolic type II fatty acid synthase complex','C','OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol.','2013-10-27','NSRP'),(15065,31377,'mitochondrial type II fatty acid synthase complex','C','OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion.','2013-10-27','NSRP'),(15066,31378,'plastid type II fatty acid synthase complex','C','OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid.','2013-10-27','NSRP'),(15067,31379,'RNA-directed RNA polymerase complex','C','A protein complex that possesses RNA-directed RNA polymerase activity.','2013-10-27','NSRP'),(15068,31380,'nuclear RNA-directed RNA polymerase complex','C','A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.','2013-10-27','NSRP'),(15069,31381,'viral RNA-directed RNA polymerase complex','C','A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus.','2013-10-27','NSRP'),(15070,31382,'mating projection assembly','P','The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi.','2013-10-27','NSRP'),(15071,31383,'regulation of mating projection assembly','P','Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi.','2013-10-27','NSRP'),(15072,31384,'regulation of initiation of mating projection growth','P','Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi.','2013-10-27','NSRP'),(15073,31385,'regulation of termination of mating projection growth','P','Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi.','2013-10-27','NSRP'),(15074,31386,'protein tag','F','Acting as an indicator or marker to facilitate recognition by other molecules in the cell. Recognition of the tag, which can be covalently attached to the target molecule, may result in modification, sequestration, transport or degradation of the molecule in question.','2013-10-27','NSRP'),(15075,31387,'MPF complex','C','A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC).','2013-10-27','NSRP'),(15076,31388,'organic acid phosphorylation','P','The process of introducing one or more phosphate groups into an organic acid.','2013-10-27','NSRP'),(15077,31389,'Rad17 RFC-like complex','C','A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.','2013-10-27','NSRP'),(15078,31390,'Ctf18 RFC-like complex','C','A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p.','2013-10-27','NSRP'),(15079,31391,'Elg1 RFC-like complex','C','A pentameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.','2013-10-27','NSRP'),(15080,31392,'regulation of prostaglandin biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.','2013-10-27','NSRP'),(15081,31393,'negative regulation of prostaglandin biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.','2013-10-27','NSRP'),(15082,31394,'positive regulation of prostaglandin biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.','2013-10-27','NSRP'),(15083,31395,'bursicon neuropeptide hormone complex','C','A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits.','2013-10-27','NSRP'),(15084,31396,'regulation of protein ubiquitination','P','Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.','2013-10-27','NSRP'),(15085,31397,'negative regulation of protein ubiquitination','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.','2013-10-27','NSRP'),(15086,31398,'positive regulation of protein ubiquitination','P','Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.','2013-10-27','NSRP'),(15087,31399,'regulation of protein modification process','P','Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.','2013-10-27','NSRP'),(15088,31400,'negative regulation of protein modification process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.','2013-10-27','NSRP'),(15089,31401,'positive regulation of protein modification process','P','Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.','2013-10-27','NSRP'),(15090,31402,'sodium ion binding','F','Interacting selectively and non-covalently with sodium ions (Na+).','2013-10-27','NSRP'),(15091,31403,'lithium ion binding','F','Interacting selectively and non-covalently with lithium ions (Li+).','2013-10-27','NSRP'),(15092,31404,'chloride ion binding','F','Interacting selectively and non-covalently with chloride ions (Cl-).','2013-10-27','NSRP'),(15093,31405,'lipoic acid binding','F','Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid.','2013-10-27','NSRP'),(15094,31406,'carboxylic acid binding','F','Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).','2013-10-27','NSRP'),(15095,31407,'oxylipin metabolic process','P','The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.','2013-10-27','NSRP'),(15096,31408,'oxylipin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.','2013-10-27','NSRP'),(15097,31409,'pigment binding','F','Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin.','2013-10-27','NSRP'),(15098,31410,'cytoplasmic vesicle','C','A vesicle formed of membrane or protein, found in the cytoplasm of a cell.','2013-10-27','NSRP'),(15099,31411,'gas vesicle','C','A hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content aquatic microbes are able to perform vertical migrations.','2013-10-27','NSRP'),(15100,31412,'gas vesicle organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps.','2013-10-27','NSRP'),(15101,31413,'regulation of buoyancy','P','Any process that modulates an organism\'s tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases.','2013-10-27','NSRP'),(15102,31414,'N-terminal protein acetyltransferase complex','C','A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule.','2013-10-27','NSRP'),(15103,31415,'NatA complex','C','A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.','2013-10-27','NSRP'),(15104,31416,'NatB complex','C','A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.','2013-10-27','NSRP'),(15105,31417,'NatC complex','C','A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.','2013-10-27','NSRP'),(15106,31418,'L-ascorbic acid binding','F','Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.','2013-10-27','NSRP'),(15107,31419,'cobalamin binding','F','Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.','2013-10-27','NSRP'),(15108,31420,'alkali metal ion binding','F','Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen.','2013-10-27','NSRP'),(15109,31421,'invertasome','C','A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts.','2013-10-27','NSRP'),(15110,31422,'RecQ helicase-Topo III complex','C','A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human.','2013-10-27','NSRP'),(15111,31423,'hexon binding','F','Interacting selectively and non-covalently with a hexon, the major protein component of the icosahedral capsid of an adenovirus.','2013-10-27','NSRP'),(15112,31424,'keratinization','P','The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.','2013-10-27','NSRP'),(15113,31425,'chloroplast RNA processing','P','The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules.','2013-10-27','NSRP'),(15114,31426,'polycistronic mRNA processing','P','The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules.','2013-10-27','NSRP'),(15115,31427,'response to methotrexate','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.','2013-10-27','NSRP'),(15116,31428,'box C/D snoRNP complex','C','A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type that can carry out ribose-2\'-O-methylation of target RNAs.','2013-10-27','NSRP'),(15117,31429,'box H/ACA snoRNP complex','C','A box H/ACA RNP complex that is located in the nucleolus.','2013-10-27','NSRP'),(15118,31430,'M band','C','The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.','2013-10-27','NSRP'),(15119,31431,'Dbf4-dependent protein kinase complex','C','A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.','2013-10-27','NSRP'),(15120,31432,'titin binding','F','Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.','2013-10-27','NSRP'),(15121,31433,'telethonin binding','F','Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.','2013-10-27','NSRP'),(15122,31434,'mitogen-activated protein kinase kinase binding','F','Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase.','2013-10-27','NSRP'),(15123,31435,'mitogen-activated protein kinase kinase kinase binding','F','Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.','2013-10-27','NSRP'),(15124,31436,'BRCA1-BARD1 complex','C','A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage.','2013-10-27','NSRP'),(15125,31437,'regulation of mRNA cleavage','P','Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.','2013-10-27','NSRP'),(15126,31438,'negative regulation of mRNA cleavage','P','Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage.','2013-10-27','NSRP'),(15127,31439,'positive regulation of mRNA cleavage','P','Any process that activates or increases the frequency, rate or extent of mRNA cleavage.','2013-10-27','NSRP'),(15128,31440,'regulation of mRNA 3\'-end processing','P','Any process that modulates the frequency, rate or extent of mRNA 3\'-end processing, any process involved in forming the mature 3\' end of an mRNA molecule.','2013-10-27','NSRP'),(15129,31441,'negative regulation of mRNA 3\'-end processing','P','Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3\'-end processing.','2013-10-27','NSRP'),(15130,31442,'positive regulation of mRNA 3\'-end processing','P','Any process that activates or increases the frequency, rate or extent of mRNA 3\'-end processing.','2013-10-27','NSRP'),(15131,31443,'fast-twitch skeletal muscle fiber contraction','P','A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability.','2013-10-27','NSRP'),(15132,31444,'slow-twitch skeletal muscle fiber contraction','P','A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.','2013-10-27','NSRP'),(15133,31445,'regulation of heterochromatin assembly','P','Any process that modulates the frequency, rate, extent or location of heterochromatin formation.','2013-10-27','NSRP'),(15134,31446,'regulation of fast-twitch skeletal muscle fiber contraction','P','Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction.','2013-10-27','NSRP'),(15135,31447,'negative regulation of fast-twitch skeletal muscle fiber contraction','P','Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction.','2013-10-27','NSRP'),(15136,31448,'positive regulation of fast-twitch skeletal muscle fiber contraction','P','Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction.','2013-10-27','NSRP'),(15137,31449,'regulation of slow-twitch skeletal muscle fiber contraction','P','Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction.','2013-10-27','NSRP'),(15138,31450,'negative regulation of slow-twitch skeletal muscle fiber contraction','P','Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction.','2013-10-27','NSRP'),(15139,31451,'positive regulation of slow-twitch skeletal muscle fiber contraction','P','Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction.','2013-10-27','NSRP'),(15140,31452,'negative regulation of heterochromatin assembly','P','Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation.','2013-10-27','NSRP'),(15141,31453,'positive regulation of heterochromatin assembly','P','Any process that activates or increases the frequency, rate or extent of heterochromatin formation.','2013-10-27','NSRP'),(15142,31454,'regulation of extent of heterochromatin assembly','P','Any process that modulates the extent or location of heterochromatin formation.','2013-10-27','NSRP'),(15143,31455,'glycine betaine metabolic process','P','The chemical reactions and pathways involving glycine betaine, N-trimethylglycine.','2013-10-27','NSRP'),(15144,31456,'glycine betaine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine.','2013-10-27','NSRP'),(15145,31457,'glycine betaine catabolic process','P','The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine.','2013-10-27','NSRP'),(15146,31458,'betaine-transporting ATPase activity','F','Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in).','2013-10-27','NSRP'),(15147,31459,'glycine betaine-transporting ATPase activity','F','Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in).','2013-10-27','NSRP'),(15148,31460,'glycine betaine transport','P','The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15149,31461,'cullin-RING ubiquitin ligase complex','C','Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.','2013-10-27','NSRP'),(15150,31462,'Cul2-RING ubiquitin ligase complex','C','A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.','2013-10-27','NSRP'),(15151,31463,'Cul3-RING ubiquitin ligase complex','C','A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.','2013-10-27','NSRP'),(15152,31464,'Cul4A-RING ubiquitin ligase complex','C','A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.','2013-10-27','NSRP'),(15153,31465,'Cul4B-RING ubiquitin ligase complex','C','A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.','2013-10-27','NSRP'),(15154,31466,'Cul5-RING ubiquitin ligase complex','C','A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.','2013-10-27','NSRP'),(15155,31467,'Cul7-RING ubiquitin ligase complex','C','A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.','2013-10-27','NSRP'),(15156,31468,'nuclear envelope reassembly','P','The reformation of the nuclear envelope following its breakdown in the context of a normal process.','2013-10-27','NSRP'),(15157,31469,'polyhedral organelle','C','An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.','2013-10-27','NSRP'),(15158,31470,'carboxysome','C','An organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions.','2013-10-27','NSRP'),(15159,31471,'ethanolamine degradation polyhedral organelle','C','An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase.','2013-10-27','NSRP'),(15160,31472,'propanediol degradation polyhedral organelle','C','An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase.','2013-10-27','NSRP'),(15161,31473,'myosin III binding','F','Interacting selectively and non-covalently with a class III myosin; myosin III is monomeric and has an N terminal kinase domain.','2013-10-27','NSRP'),(15162,31474,'myosin IV complex','C','A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV.','2013-10-27','NSRP'),(15163,31475,'myosin V complex','C','A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region.','2013-10-27','NSRP'),(15164,31476,'myosin VI complex','C','A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.','2013-10-27','NSRP'),(15165,31477,'myosin VII complex','C','A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain.','2013-10-27','NSRP'),(15166,31478,'myosin VIII complex','C','A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain.','2013-10-27','NSRP'),(15167,31479,'myosin IX complex','C','A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins.','2013-10-27','NSRP'),(15168,31480,'myosin X complex','C','A myosin complex containing one or more class X myosin heavy chains and associated light chains.','2013-10-27','NSRP'),(15169,31481,'myosin XI complex','C','A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions.','2013-10-27','NSRP'),(15170,31482,'myosin XII complex','C','A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil.','2013-10-27','NSRP'),(15171,31483,'myosin XIII complex','C','A myosin complex containing one or more class XIII myosin heavy chains and associated light chains.','2013-10-27','NSRP'),(15172,31484,'myosin XIV complex','C','A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails.','2013-10-27','NSRP'),(15173,31485,'myosin XV complex','C','A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII.','2013-10-27','NSRP'),(15174,31486,'myosin XVI complex','C','A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat.','2013-10-27','NSRP'),(15175,31487,'myosin XVII complex','C','A myosin complex containing one or more class XVII myosin heavy chains and associated light chains.','2013-10-27','NSRP'),(15176,31488,'myosin XVIII complex','C','A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain.','2013-10-27','NSRP'),(15177,31489,'myosin V binding','F','Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport.','2013-10-27','NSRP'),(15178,31490,'chromatin DNA binding','F','Interacting selectively and non-covalently with DNA that is assembled into chromatin.','2013-10-27','NSRP'),(15179,31491,'nucleosome binding','F','Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.','2013-10-27','NSRP'),(15180,31492,'nucleosomal DNA binding','F','Interacting selectively and non-covalently with the DNA portion of a nucleosome.','2013-10-27','NSRP'),(15181,31493,'nucleosomal histone binding','F','Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.','2013-10-27','NSRP'),(15182,31494,'regulation of mating type switching','P','Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus.','2013-10-27','NSRP'),(15183,31495,'negative regulation of mating type switching','P','Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching.','2013-10-27','NSRP'),(15184,31496,'positive regulation of mating type switching','P','Any process that activates or increases the frequency, rate or extent of mating type switching.','2013-10-27','NSRP'),(15185,31497,'chromatin assembly','P','The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus.','2013-10-27','NSRP'),(15186,31498,'chromatin disassembly','P','The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA.','2013-10-27','NSRP'),(15187,31499,'TRAMP complex','C','A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3\'-end processing and in RNA surveillance and quality control.','2013-10-27','NSRP'),(15188,31500,'Tea1 cell-end complex','C','A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity.','2013-10-27','NSRP'),(15189,31501,'mannosyltransferase complex','C','A complex that posseses mannosyltransferase activity.','2013-10-27','NSRP'),(15190,31502,'dolichyl-phosphate-mannose-protein mannosyltransferase complex','C','A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies.','2013-10-27','NSRP'),(15191,31503,'protein complex localization','P','A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.','2013-10-27','NSRP'),(15192,31504,'peptidoglycan-based cell wall organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall.','2013-10-27','NSRP'),(15193,31505,'fungal-type cell wall organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.','2013-10-27','NSRP'),(15194,31506,'cell wall glycoprotein biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues.','2013-10-27','NSRP'),(15195,31507,'heterochromatin assembly','P','The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent.','2013-10-27','NSRP'),(15196,31508,'centromeric heterochromatin assembly','P','The assembly of chromatin into heterochromatin near the centromere.','2013-10-27','NSRP'),(15197,31509,'telomeric heterochromatin assembly','P','The assembly of chromatin into heterochromatin at the telomere.','2013-10-27','NSRP'),(15198,31510,'SUMO activating enzyme complex','C','A conserved heterodimeric complex with SUMO activating enzyme activity.','2013-10-27','NSRP'),(15199,31511,'Mis6-Sim4 complex','C','A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.','2013-10-27','NSRP'),(15200,31512,'motile primary cilium','C','A primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors. Motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization.','2013-10-27','NSRP'),(15201,31513,'nonmotile primary cilium','C','A primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules.','2013-10-27','NSRP'),(15202,31514,'motile cilium','C','A cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface. Motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues. Motile cilia may also function as sensory organelles.','2013-10-27','NSRP'),(15203,31515,'tRNA (m1A) methyltransferase complex','C','A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer.','2013-10-27','NSRP'),(15204,31516,'far-red light photoreceptor activity','F','The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation.','2013-10-27','NSRP'),(15205,31517,'red light photoreceptor activity','F','The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation.','2013-10-27','NSRP'),(15206,31518,'CBF3 complex','C','A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p.','2013-10-27','NSRP'),(15207,31519,'PcG protein complex','C','A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.','2013-10-27','NSRP'),(15208,31520,'plasma membrane of cell tip','C','The portion of the plasma membrane surrounding the cell tip.','2013-10-27','NSRP'),(15209,31521,'spitzenkorper','C','Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments.','2013-10-27','NSRP'),(15210,31522,'cell envelope Sec protein transport complex','C','A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC.','2013-10-27','NSRP'),(15211,31523,'Myb complex','C','A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.','2013-10-27','NSRP'),(15212,31524,'menthol metabolic process','P','The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol.','2013-10-27','NSRP'),(15213,31525,'menthol biosynthetic process','P','The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol.','2013-10-27','NSRP'),(15214,31526,'brush border membrane','C','The portion of the plasma membrane surrounding the brush border.','2013-10-27','NSRP'),(15215,31527,'filopodium membrane','C','The portion of the plasma membrane surrounding a filopodium.','2013-10-27','NSRP'),(15216,31528,'microvillus membrane','C','The portion of the plasma membrane surrounding a microvillus.','2013-10-27','NSRP'),(15217,31529,'ruffle organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.','2013-10-27','NSRP'),(15218,31530,'gonadotropin-releasing hormone receptor binding','F','Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.','2013-10-27','NSRP'),(15219,31531,'thyrotropin-releasing hormone receptor binding','F','Interacting selectively and non-covalently with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.','2013-10-27','NSRP'),(15220,31532,'actin cytoskeleton reorganization','P','A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.','2013-10-27','NSRP'),(15221,31533,'mRNA cap methyltransferase complex','C','A protein complex that consists of an RNA 5\' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping.','2013-10-27','NSRP'),(15222,31534,'minus-end directed microtubule sliding','P','The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules.','2013-10-27','NSRP'),(15223,31535,'plus-end directed microtubule sliding','P','The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules.','2013-10-27','NSRP'),(15224,31536,'positive regulation of exit from mitosis','P','Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).','2013-10-27','NSRP'),(15225,31537,'regulation of anthocyanin metabolic process','P','Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins.','2013-10-27','NSRP'),(15226,31538,'negative regulation of anthocyanin metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins.','2013-10-27','NSRP'),(15227,31539,'positive regulation of anthocyanin metabolic process','P','Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins.','2013-10-27','NSRP'),(15228,31540,'regulation of anthocyanin biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins.','2013-10-27','NSRP'),(15229,31541,'negative regulation of anthocyanin biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins.','2013-10-27','NSRP'),(15230,31542,'positive regulation of anthocyanin biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins.','2013-10-27','NSRP'),(15231,31543,'peptidyl-proline dioxygenase activity','F','Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2.','2013-10-27','NSRP'),(15232,31544,'peptidyl-proline 3-dioxygenase activity','F','Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2.','2013-10-27','NSRP'),(15233,31545,'peptidyl-proline 4-dioxygenase activity','F','Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2.','2013-10-27','NSRP'),(15234,31546,'brain-derived neurotrophic factor receptor binding','F','Interacting selectively and non-covalently with the brain-derived neurotrophic factor receptor.','2013-10-27','NSRP'),(15235,31547,'brain-derived neurotrophic factor receptor signaling pathway','P','The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.','2013-10-27','NSRP'),(15236,31548,'regulation of brain-derived neurotrophic factor receptor signaling pathway','P','Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.','2013-10-27','NSRP'),(15237,31549,'negative regulation of brain-derived neurotrophic factor receptor signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.','2013-10-27','NSRP'),(15238,31550,'positive regulation of brain-derived neurotrophic factor receptor signaling pathway','P','Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.','2013-10-27','NSRP'),(15239,31551,'regulation of brain-derived neurotrophic factor-activated receptor activity','P','Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.','2013-10-27','NSRP'),(15240,31552,'negative regulation of brain-derived neurotrophic factor-activated receptor activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.','2013-10-27','NSRP'),(15241,31553,'positive regulation of brain-derived neurotrophic factor-activated receptor activity','P','Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.','2013-10-27','NSRP'),(15242,31554,'regulation of DNA-dependent transcription, termination','P','Any process that modulates the frequency, rate, extent, or location of DNA-dependent transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.','2013-10-27','NSRP'),(15243,31555,'transcriptional attenuation','P','Regulation of transcription through variation in where transcription termination occurs.','2013-10-27','NSRP'),(15244,31556,'transcriptional attenuation by ribosome','P','A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch.','2013-10-27','NSRP'),(15245,31557,'induction of programmed cell death in response to chemical stimulus','P','OBSOLETE. A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus.','2013-10-27','NSRP'),(15246,31558,'induction of apoptosis in response to chemical stimulus','P','OBSOLETE. Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus.','2013-10-27','NSRP'),(15247,31559,'oxidosqualene cyclase activity','F','Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene.','2013-10-27','NSRP'),(15248,31560,'cellular bud neck polarisome','C','Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis.','2013-10-27','NSRP'),(15249,31561,'cellular bud tip polarisome','C','Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud.','2013-10-27','NSRP'),(15250,31562,'hyphal tip polarisome','C','Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha.','2013-10-27','NSRP'),(15251,31563,'mating projection tip polarisome','C','Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone.','2013-10-27','NSRP'),(15252,31564,'transcription antitermination','P','Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond a termination site.','2013-10-27','NSRP'),(15253,31565,'cytokinesis checkpoint','P','A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates G2/M transition.','2013-10-27','NSRP'),(15254,31566,'actomyosin contractile ring maintenance','P','The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle.','2013-10-27','NSRP'),(15255,31567,'cell size control checkpoint','P','Any cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size.','2013-10-27','NSRP'),(15256,31568,'G1 cell size control checkpoint','P','A cell cycle checkpoint that monitors cell size, and negatively regulates cell cycle progression between G1 and S phase until a critical size is reached.','2013-10-27','NSRP'),(15257,31569,'G2 cell size control checkpoint','P','A cell cycle checkpoint that monitors cell size, and negatively regulates cell cycle progression between G2 and M phase until a critical size is reached.','2013-10-27','NSRP'),(15258,31570,'DNA integrity checkpoint','P','A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.','2013-10-27','NSRP'),(15259,31571,'mitotic G1 DNA damage checkpoint','P','A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage.','2013-10-27','NSRP'),(15260,31572,'G2 DNA damage checkpoint','P','A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage.','2013-10-27','NSRP'),(15261,31573,'intra-S DNA damage checkpoint','P','A cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.','2013-10-27','NSRP'),(15262,31575,'mitotic cell cycle G1/S transition checkpoint','P','A cell cycle checkpoint that blocks entry into S phase of the mitotic cell cycle.','2012-03-14','NSRP'),(15263,31576,'G2/M transition checkpoint','P','A cell cycle checkpoint that blocks entry into M phase.','2012-03-14','NSRP'),(15264,31577,'spindle checkpoint','P','A cell cycle checkpoint that delays progression through the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.','2013-10-27','NSRP'),(15265,31578,'mitotic spindle orientation checkpoint','P','A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected.','2013-10-27','NSRP'),(15266,31579,'membrane raft organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.','2013-10-27','NSRP'),(15267,31580,'membrane raft distribution','P','The process that establishes the spatial arrangement of membrane rafts within a cellular membrane.','2013-10-27','NSRP'),(15268,31581,'hemidesmosome assembly','P','Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina.','2013-10-27','NSRP'),(15269,31582,'replication fork arrest at rDNA repeats','P','A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer.','2013-10-27','NSRP'),(15270,31583,'phospholipase D-activating G-protein coupled receptor signaling pathway','P','The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA).','2013-10-27','NSRP'),(15271,31584,'activation of phospholipase D activity','P','Any process that initiates the activity of inactive phospholipase D.','2013-10-27','NSRP'),(15272,31585,'regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity','P','Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.','2013-10-27','NSRP'),(15273,31586,'negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.','2013-10-27','NSRP'),(15274,31587,'positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity','P','Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.','2013-10-27','NSRP'),(15275,31588,'AMP-activated protein kinase complex','C','A protein complex that possesses AMP-dependent protein kinase activity.','2013-10-27','NSRP'),(15276,31589,'cell-substrate adhesion','P','The attachment of a cell to the underlying substrate via adhesion molecules.','2013-10-27','NSRP'),(15277,31590,'wybutosine metabolic process','P','The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.','2013-10-27','NSRP'),(15278,31591,'wybutosine biosynthetic process','P','The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.','2013-10-27','NSRP'),(15279,31592,'centrosomal corona','C','An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin.','2013-10-27','NSRP'),(15280,31593,'polyubiquitin binding','F','Interacting selectively and non-covalently with a polymer of ubiqutin.','2013-10-27','NSRP'),(15281,31594,'neuromuscular junction','C','The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.','2013-10-27','NSRP'),(15282,31595,'nuclear proteasome complex','C','A proteasome found in the nucleus of a cell.','2013-10-27','NSRP'),(15283,31596,'ER proteasome complex','C','A proteasome found in the endoplasmic reticulum of a cell.','2013-10-27','NSRP'),(15284,31597,'cytosolic proteasome complex','C','A proteasome complex found in the cytosol of a cell.','2013-10-27','NSRP'),(15285,31598,'nuclear proteasome regulatory particle','C','The regulatory subcomplex of a proteasome located in the nucleus of a cell.','2013-10-27','NSRP'),(15286,31599,'ER proteasome regulatory particle','C','The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell.','2013-10-27','NSRP'),(15287,31600,'cytosolic proteasome regulatory particle','C','A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex.','2013-10-27','NSRP'),(15288,31601,'nuclear proteasome core complex','C','The core complex of a proteasome located in the nucleus of a cell.','2013-10-27','NSRP'),(15289,31602,'ER proteasome core complex','C','The core complex of a proteasome located in the endoplasmic reticulum of a cell.','2013-10-27','NSRP'),(15290,31603,'cytosolic proteasome core complex','C','The core complex of a proteasome located in the cytosol of a cell.','2013-10-27','NSRP'),(15291,31604,'nuclear proteasome core complex, alpha-subunit complex','C','The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell.','2013-10-27','NSRP'),(15292,31605,'ER proteasome core complex, alpha-subunit complex','C','The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell.','2013-10-27','NSRP'),(15293,31606,'cytosolic proteasome core complex, alpha-subunit complex','C','The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex.','2013-10-27','NSRP'),(15294,31607,'nuclear proteasome core complex, beta-subunit complex','C','The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell.','2013-10-27','NSRP'),(15295,31608,'ER proteasome core complex, beta-subunit complex','C','The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell.','2013-10-27','NSRP'),(15296,31609,'cytosolic proteasome core complex, beta-subunit complex','C','The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex.','2013-10-27','NSRP'),(15297,31610,'nuclear proteasome regulatory particle, base subcomplex','C','The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell.','2013-10-27','NSRP'),(15298,31611,'ER proteasome regulatory particle, base subcomplex','C','The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell.','2013-10-27','NSRP'),(15299,31612,'cytosolic proteasome regulatory particle, base subcomplex','C','The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell.','2013-10-27','NSRP'),(15300,31613,'nuclear proteasome regulatory particle, lid subcomplex','C','The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell.','2013-10-27','NSRP'),(15301,31614,'ER proteasome regulatory particle, lid subcomplex','C','The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell.','2013-10-27','NSRP'),(15302,31615,'cytosolic proteasome regulatory particle, lid subcomplex','C','The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.','2013-10-27','NSRP'),(15303,31616,'spindle pole centrosome','C','A centrosome from which one pole of a mitotic or meiotic spindle is organized.','2013-10-27','NSRP'),(15304,31617,'NMS complex','C','A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes.','2013-10-27','NSRP'),(15305,31618,'nuclear centromeric heterochromatin','C','A region of heterochromatin located near the centromere of a chromosome in the nucleus.','2013-10-27','NSRP'),(15306,31619,'homologous chromosome orientation involved in meiotic metaphase I plate congression','P','The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I.','2013-10-27','NSRP'),(15307,31620,'regulation of fever generation','P','Any process that modulates the rate or extent of fever generation.','2013-10-27','NSRP'),(15308,31621,'negative regulation of fever generation','P','Any process that stops, prevents, or reduces the rate or extent of fever generation.','2013-10-27','NSRP'),(15309,31622,'positive regulation of fever generation','P','Any process that activates or increases the frequency, rate, or extent of fever generation.','2013-10-27','NSRP'),(15310,31623,'receptor internalization','P','A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.','2013-10-27','NSRP'),(15311,31624,'ubiquitin conjugating enzyme binding','F','Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins.','2013-10-27','NSRP'),(15312,31625,'ubiquitin protein ligase binding','F','Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.','2013-10-27','NSRP'),(15313,31626,'beta-endorphin binding','F','Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin.','2013-10-27','NSRP'),(15314,31627,'telomeric loop formation','P','The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3\' single-stranded overhang into the duplex region.','2013-10-27','NSRP'),(15315,31628,'opioid receptor binding','F','Interacting selectively and non-covalently with an opioid receptor.','2013-10-27','NSRP'),(15316,31629,'synaptic vesicle fusion to presynaptic membrane','P','Fusion of the membrane of a synaptic vesicle with its target presynaptic membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.','2013-10-27','NSRP'),(15317,31630,'regulation of synaptic vesicle fusion to presynaptic membrane','P','Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.','2013-10-27','NSRP'),(15318,31631,'negative regulation of synaptic vesicle fusion to presynaptic membrane','P','Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.','2013-10-27','NSRP'),(15319,31632,'positive regulation of synaptic vesicle fusion to presynaptic membrane','P','Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.','2013-10-27','NSRP'),(15320,31633,'xanthophore','C','A chromatophore containing yellow pigment.','2013-10-27','NSRP'),(15321,31634,'replication fork barrier binding','F','Interacting selectively and non-covalently with replication fork barriers, sites that inhibit the progress of replication forks.','2013-10-27','NSRP'),(15322,31635,'adenylate cyclase-inhibiting opioid receptor signaling pathway','P','The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP).','2013-10-27','NSRP'),(15323,31637,'regulation of neuronal synaptic plasticity in response to neurotrophin','P','The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.','2013-10-27','NSRP'),(15324,31638,'zymogen activation','P','The proteolytic processing of an inactive enzyme to an active form.','2013-10-27','NSRP'),(15325,31639,'plasminogen activation','P','The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.','2013-10-27','NSRP'),(15326,31640,'killing of cells of other organism','P','Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.','2013-10-27','NSRP'),(15327,31641,'regulation of myelination','P','Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.','2013-10-27','NSRP'),(15328,31642,'negative regulation of myelination','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.','2013-10-27','NSRP'),(15329,31643,'positive regulation of myelination','P','Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.','2013-10-27','NSRP'),(15330,31644,'regulation of neurological system process','P','Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system.','2013-10-27','NSRP'),(15331,31645,'negative regulation of neurological system process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.','2013-10-27','NSRP'),(15332,31646,'positive regulation of neurological system process','P','Any process that activates or increases the frequency, rate or extent of a neurophysiological process.','2013-10-27','NSRP'),(15333,31647,'regulation of protein stability','P','Any process that affects the structure and integrity of a protein by altering the likelihood of its degradation or aggregation.','2013-10-27','NSRP'),(15334,31648,'protein destabilization','P','Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.','2013-10-27','NSRP'),(15335,31649,'heat generation','P','Any homeostatic process in which an organism produces heat, thereby raising its internal temperature.','2013-10-27','NSRP'),(15336,31650,'regulation of heat generation','P','Any process that modulates the rate or extent of heat generation.','2013-10-27','NSRP'),(15337,31651,'negative regulation of heat generation','P','Any process that stops, prevents, or reduces the rate or extent of heat generation.','2013-10-27','NSRP'),(15338,31652,'positive regulation of heat generation','P','Any process that activates or increases the rate or extent of heat generation.','2013-10-27','NSRP'),(15339,31653,'heat dissipation','P','Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature.','2013-10-27','NSRP'),(15340,31654,'regulation of heat dissipation','P','Any process that modulates the rate or extent of heat dissipation.','2013-10-27','NSRP'),(15341,31655,'negative regulation of heat dissipation','P','Any process that stops, prevents, or reduces the rate or extent of heat dissipation.','2013-10-27','NSRP'),(15342,31656,'positive regulation of heat dissipation','P','Any process that activates or increases the rate or extent of heat dissipation.','2013-10-27','NSRP'),(15343,31657,'regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle','P','Any process that controls the frequency, rate or extent of G1 cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle.','2013-10-27','NSRP'),(15344,31658,'negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle','P','Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle.','2013-10-27','NSRP'),(15345,31659,'positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle','P','Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle.','2013-10-27','NSRP'),(15346,31660,'regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle','P','Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle.','2013-10-27','NSRP'),(15347,31661,'negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle','P','Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle.','2013-10-27','NSRP'),(15348,31662,'positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle','P','Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity involved in the G2/M transition of the cell cycle.','2013-10-27','NSRP'),(15349,31663,'lipopolysaccharide-mediated signaling pathway','P','A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.','2013-10-27','NSRP'),(15350,31664,'regulation of lipopolysaccharide-mediated signaling pathway','P','Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.','2013-10-27','NSRP'),(15351,31665,'negative regulation of lipopolysaccharide-mediated signaling pathway','P','Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.','2013-10-27','NSRP'),(15352,31666,'positive regulation of lipopolysaccharide-mediated signaling pathway','P','Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.','2013-10-27','NSRP'),(15353,31667,'response to nutrient levels','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.','2013-10-27','NSRP'),(15354,31668,'cellular response to extracellular stimulus','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.','2013-10-27','NSRP'),(15355,31669,'cellular response to nutrient levels','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.','2013-10-27','NSRP'),(15356,31670,'cellular response to nutrient','P','Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.','2013-10-27','NSRP'),(15357,31671,'primary cell septum biogenesis','P','A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division.','2013-10-27','NSRP'),(15358,31672,'A band','C','The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.','2013-10-27','NSRP'),(15359,31673,'H zone','C','A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments.','2013-10-27','NSRP'),(15360,31674,'I band','C','A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.','2013-10-27','NSRP'),(15361,31676,'plasma membrane-derived thylakoid membrane','C','The pigmented membrane of a plasma membrane-derived thylakoid.','2013-10-27','NSRP'),(15362,31679,'NADH dehydrogenase (plastoquinone) activity','F','Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol.','2013-10-27','NSRP'),(15363,31680,'G-protein beta/gamma-subunit complex','C','The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange.','2013-10-27','NSRP'),(15364,31681,'G-protein beta-subunit binding','F','Interacting selectively and non-covalently with a G-protein beta subunit.','2013-10-27','NSRP'),(15365,31682,'G-protein gamma-subunit binding','F','Interacting selectively and non-covalently with a G-protein gamma subunit.','2013-10-27','NSRP'),(15366,31683,'G-protein beta/gamma-subunit complex binding','F','Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits.','2013-10-27','NSRP'),(15367,31684,'heterotrimeric G-protein complex cycle','P','The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits.','2013-10-27','NSRP'),(15368,31685,'adenosine receptor binding','F','Interacting selectively and non-covalently with an adenosine receptor.','2013-10-27','NSRP'),(15369,31686,'A1 adenosine receptor binding','F','Interacting selectively and non-covalently with an A1 adenosine receptor.','2013-10-27','NSRP'),(15370,31687,'A2A adenosine receptor binding','F','Interacting selectively and non-covalently with an A2A adenosine receptor.','2013-10-27','NSRP'),(15371,31688,'A2B adenosine receptor binding','F','Interacting selectively and non-covalently with an A2B adenosine receptor.','2013-10-27','NSRP'),(15372,31689,'A3 adenosine receptor binding','F','Interacting selectively and non-covalently with an A3 adenosine receptor.','2013-10-27','NSRP'),(15373,31690,'adrenergic receptor binding','F','Interacting selectively and non-covalently with an adrenergic receptor.','2013-10-27','NSRP'),(15374,31691,'alpha-1A adrenergic receptor binding','F','Interacting selectively and non-covalently with an alpha-1A adrenergic receptor.','2013-10-27','NSRP'),(15375,31692,'alpha-1B adrenergic receptor binding','F','Interacting selectively and non-covalently with an alpha-1B adrenergic receptor.','2013-10-27','NSRP'),(15376,31693,'alpha-1D adrenergic receptor binding','F','Interacting selectively and non-covalently with an alpha-1D adrenergic receptor.','2013-10-27','NSRP'),(15377,31694,'alpha-2A adrenergic receptor binding','F','Interacting selectively and non-covalently with an alpha-2A adrenergic receptor.','2013-10-27','NSRP'),(15378,31695,'alpha-2B adrenergic receptor binding','F','Interacting selectively and non-covalently with an alpha-2B adrenergic receptor.','2013-10-27','NSRP'),(15379,31696,'alpha-2C adrenergic receptor binding','F','Interacting selectively and non-covalently with an alpha-2C adrenergic receptor.','2013-10-27','NSRP'),(15380,31697,'beta-1 adrenergic receptor binding','F','Interacting selectively and non-covalently with a beta-1 adrenergic receptor.','2013-10-27','NSRP'),(15381,31698,'beta-2 adrenergic receptor binding','F','Interacting selectively and non-covalently with a beta-2 adrenergic receptor.','2013-10-27','NSRP'),(15382,31699,'beta-3 adrenergic receptor binding','F','Interacting selectively and non-covalently with a beta-3 adrenergic receptor.','2013-10-27','NSRP'),(15383,31700,'adrenomedullin receptor binding','F','Interacting selectively and non-covalently with an adrenomedullin receptor.','2013-10-27','NSRP'),(15384,31701,'angiotensin receptor binding','F','Interacting selectively and non-covalently with an angiotensin receptor.','2013-10-27','NSRP'),(15385,31702,'type 1 angiotensin receptor binding','F','Interacting selectively and non-covalently with a type 1 angiotensin receptor.','2013-10-27','NSRP'),(15386,31703,'type 2 angiotensin receptor binding','F','Interacting selectively and non-covalently with a type 2 angiotensin receptor.','2013-10-27','NSRP'),(15387,31704,'apelin receptor binding','F','Interacting selectively and non-covalently with an apelin receptor.','2013-10-27','NSRP'),(15388,31705,'bombesin receptor binding','F','Interacting selectively and non-covalently with a bombesin receptor.','2013-10-27','NSRP'),(15389,31706,'subtype 3 bombesin receptor binding','F','Interacting selectively and non-covalently with a subtype 3 bombesin receptor.','2013-10-27','NSRP'),(15390,31707,'endothelin A receptor binding','F','Interacting selectively and non-covalently with an endothelin A receptor.','2013-10-27','NSRP'),(15391,31708,'endothelin B receptor binding','F','Interacting selectively and non-covalently with an endothelin B receptor.','2013-10-27','NSRP'),(15392,31709,'gastrin-releasing peptide receptor binding','F','Interacting selectively and non-covalently with a gastrin-releasing peptide receptor.','2013-10-27','NSRP'),(15393,31710,'neuromedin B receptor binding','F','Interacting selectively and non-covalently with a neuromedin B receptor.','2013-10-27','NSRP'),(15394,31711,'bradykinin receptor binding','F','Interacting selectively and non-covalently with a bradykinin receptor.','2013-10-27','NSRP'),(15395,31712,'B1 bradykinin receptor binding','F','Interacting selectively and non-covalently with a B1 bradykinin receptor.','2013-10-27','NSRP'),(15396,31713,'B2 bradykinin receptor binding','F','Interacting selectively and non-covalently with a B2 bradykinin receptor.','2013-10-27','NSRP'),(15397,31714,'C5a anaphylatoxin chemotactic receptor binding','F','Interacting selectively and non-covalently with a C5a anaphylatoxin chemotactic receptor.','2013-10-27','NSRP'),(15398,31715,'C5L2 anaphylatoxin chemotactic receptor binding','F','Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor.','2013-10-27','NSRP'),(15399,31716,'calcitonin receptor binding','F','Interacting selectively and non-covalently with a calcitonin receptor.','2013-10-27','NSRP'),(15400,31717,'cannabinoid receptor binding','F','Interacting selectively and non-covalently with a cannabinoid receptor.','2013-10-27','NSRP'),(15401,31718,'type 1 cannabinoid receptor binding','F','Interacting selectively and non-covalently with a type 1 cannabinoid receptor.','2013-10-27','NSRP'),(15402,31719,'type 2 cannabinoid receptor binding','F','Interacting selectively and non-covalently with a type 2 cannabinoid receptor.','2013-10-27','NSRP'),(15403,31720,'haptoglobin binding','F','Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.','2013-10-27','NSRP'),(15404,31721,'hemoglobin alpha binding','F','Interacting selectively and non-covalently with a hemoglobin alpha chain.','2013-10-27','NSRP'),(15405,31722,'hemoglobin beta binding','F','Interacting selectively and non-covalently with a hemoglobin beta chain.','2013-10-27','NSRP'),(15406,31723,'CXCR4 chemokine receptor binding','F','Interacting selectively and non-covalently with a CXCR4 chemokine receptor.','2013-10-27','NSRP'),(15407,31724,'CXCR5 chemokine receptor binding','F','Interacting selectively and non-covalently with a CXCR5 chemokine receptor.','2013-10-27','NSRP'),(15408,31725,'CXCR6 chemokine receptor binding','F','Interacting selectively and non-covalently with a CXCR6 chemokine receptor.','2013-10-27','NSRP'),(15409,31726,'CCR1 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR1 chemokine receptor.','2013-10-27','NSRP'),(15410,31727,'CCR2 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR2 chemokine receptor.','2013-10-27','NSRP'),(15411,31728,'CCR3 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR3 chemokine receptor.','2013-10-27','NSRP'),(15412,31729,'CCR4 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR4 chemokine receptor.','2013-10-27','NSRP'),(15413,31730,'CCR5 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR5 chemokine receptor.','2013-10-27','NSRP'),(15414,31731,'CCR6 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR6 chemokine receptor.','2013-10-27','NSRP'),(15415,31732,'CCR7 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR7 chemokine receptor.','2013-10-27','NSRP'),(15416,31733,'CCR8 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR8 chemokine receptor.','2013-10-27','NSRP'),(15417,31734,'CCR9 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR9 chemokine receptor.','2013-10-27','NSRP'),(15418,31735,'CCR10 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR10 chemokine receptor.','2013-10-27','NSRP'),(15419,31736,'CCR11 chemokine receptor binding','F','Interacting selectively and non-covalently with a CCR11 chemokine receptor.','2013-10-27','NSRP'),(15420,31737,'CX3C chemokine receptor binding','F','Interacting selectively and non-covalently with a CX3C chemokine receptor.','2013-10-27','NSRP'),(15421,31738,'XCR1 chemokine receptor binding','F','Interacting selectively and non-covalently with a XCR1 chemokine receptor.','2013-10-27','NSRP'),(15422,31739,'cholecystokinin receptor binding','F','Interacting selectively and non-covalently with a cholecystokinin receptor.','2013-10-27','NSRP'),(15423,31740,'type A cholecystokinin receptor binding','F','Interacting selectively and non-covalently with a type A cholecystokinin receptor.','2013-10-27','NSRP'),(15424,31741,'type B gastrin/cholecystokinin receptor binding','F','Interacting selectively and non-covalently with a type B gastrin/cholecystokinin receptor.','2013-10-27','NSRP'),(15425,31745,'cysteinyl leukotriene receptor binding','F','Interacting selectively and non-covalently with a cysteinyl leukotriene receptor.','2013-10-27','NSRP'),(15426,31746,'type 1 cysteinyl leukotriene receptor binding','F','Interacting selectively and non-covalently with a type 1 cysteinyl leukotriene receptor.','2013-10-27','NSRP'),(15427,31747,'type 2 cysteinyl leukotriene receptor binding','F','Interacting selectively and non-covalently with a type 2 cysteinyl leukotriene receptor.','2013-10-27','NSRP'),(15428,31748,'D1 dopamine receptor binding','F','Interacting selectively and non-covalently with a D1 dopamine receptor.','2013-10-27','NSRP'),(15429,31749,'D2 dopamine receptor binding','F','Interacting selectively and non-covalently with a D2 dopamine receptor.','2013-10-27','NSRP'),(15430,31750,'D3 dopamine receptor binding','F','Interacting selectively and non-covalently with a D3 dopamine receptor.','2013-10-27','NSRP'),(15431,31751,'D4 dopamine receptor binding','F','Interacting selectively and non-covalently with a D4 dopamine receptor.','2013-10-27','NSRP'),(15432,31752,'D5 dopamine receptor binding','F','Interacting selectively and non-covalently with a D5 dopamine receptor.','2013-10-27','NSRP'),(15433,31753,'endothelial differentiation G-protein coupled receptor binding','F','Interacting selectively and non-covalently with an endothelial differentiation G-protein coupled receptor.','2013-10-27','NSRP'),(15434,31754,'Edg-1 sphingosine 1-phosphate receptor binding','F','Interacting selectively and non-covalently with an Edg-1 sphingosine 1-phosphate receptor.','2013-10-27','NSRP'),(15435,31755,'Edg-2 lysophosphatidic acid receptor binding','F','Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor.','2013-10-27','NSRP'),(15436,31756,'Edg-3 sphingosine 1-phosphate receptor binding','F','Interacting selectively and non-covalently with an Edg-3 sphingosine 1-phosphate receptor.','2013-10-27','NSRP'),(15437,31757,'Edg-4 lysophosphatidic acid receptor binding','F','Interacting selectively and non-covalently with an Edg-4 lysophosphatidic acid receptor.','2013-10-27','NSRP'),(15438,31758,'Edg-5 sphingosine 1-phosphate receptor binding','F','Interacting selectively and non-covalently with an Edg-5 sphingosine 1-phosphate receptor.','2013-10-27','NSRP'),(15439,31759,'Edg-6 sphingosine 1-phosphate receptor binding','F','Interacting selectively and non-covalently with an Edg-6 sphingosine 1-phosphate receptor.','2013-10-27','NSRP'),(15440,31760,'Edg-7 lysophosphatidic acid receptor binding','F','Interacting selectively and non-covalently with an Edg-7 lysophosphatidic acid receptor.','2013-10-27','NSRP'),(15441,31761,'fMet-Leu-Phe receptor binding','F','Interacting selectively and non-covalently with a fMet-Leu-Phe receptor.','2013-10-27','NSRP'),(15442,31762,'follicle-stimulating hormone receptor binding','F','Interacting selectively and non-covalently with a follicle-stimulating hormone receptor.','2013-10-27','NSRP'),(15443,31763,'galanin receptor binding','F','Interacting selectively and non-covalently with a galanin receptor.','2013-10-27','NSRP'),(15444,31764,'type 1 galanin receptor binding','F','Interacting selectively and non-covalently with a type 1 galanin receptor.','2013-10-27','NSRP'),(15445,31765,'type 2 galanin receptor binding','F','Interacting selectively and non-covalently with a type 2 galanin receptor.','2013-10-27','NSRP'),(15446,31766,'type 3 galanin receptor binding','F','Interacting selectively and non-covalently with a type 3 galanin receptor.','2013-10-27','NSRP'),(15447,31767,'gastric inhibitory polypeptide receptor binding','F','Interacting selectively and non-covalently with a gastric inhibitory polypeptide receptor.','2013-10-27','NSRP'),(15448,31768,'ghrelin receptor binding','F','Interacting selectively and non-covalently with a ghrelin receptor.','2013-10-27','NSRP'),(15449,31769,'glucagon receptor binding','F','Interacting selectively and non-covalently with a glucagon receptor.','2013-10-27','NSRP'),(15450,31770,'growth hormone-releasing hormone receptor binding','F','Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor.','2013-10-27','NSRP'),(15451,31771,'type 1 hypocretin receptor binding','F','Interacting selectively and non-covalently with a type 1 hypocretin receptor.','2013-10-27','NSRP'),(15452,31772,'type 2 hypocretin receptor binding','F','Interacting selectively and non-covalently with a type 2 hypocretin receptor.','2013-10-27','NSRP'),(15453,31773,'kisspeptin receptor binding','F','Interacting selectively and non-covalently with a kisspeptin receptor.','2013-10-27','NSRP'),(15454,31774,'leukotriene receptor binding','F','Interacting selectively and non-covalently with a leukotriene receptor.','2013-10-27','NSRP'),(15455,31775,'lutropin-choriogonadotropic hormone receptor binding','F','Interacting selectively and non-covalently with a lutropin-choriogonadotropic hormone receptor.','2013-10-27','NSRP'),(15456,31776,'melanin-concentrating hormone receptor binding','F','Interacting selectively and non-covalently with a melanin-concentrating hormone receptor.','2013-10-27','NSRP'),(15457,31777,'type 1 melanin-concentrating hormone receptor binding','F','Interacting selectively and non-covalently with a type 1 melanin-concentrating hormone receptor.','2013-10-27','NSRP'),(15458,31778,'type 2 melanin-concentrating hormone receptor binding','F','Interacting selectively and non-covalently with a type 2 melanin-concentrating hormone receptor.','2013-10-27','NSRP'),(15459,31779,'melanocortin receptor binding','F','Interacting selectively and non-covalently with a melanocortin receptor.','2013-10-27','NSRP'),(15460,31780,'corticotropin hormone receptor binding','F','Interacting selectively and non-covalently with a corticotropin hormone receptor.','2013-10-27','NSRP'),(15461,31781,'type 3 melanocortin receptor binding','F','Interacting selectively and non-covalently with a type 3 melanocortin receptor.','2013-10-27','NSRP'),(15462,31782,'type 4 melanocortin receptor binding','F','Interacting selectively and non-covalently with a type 4 melanocortin receptor.','2013-10-27','NSRP'),(15463,31783,'type 5 melanocortin receptor binding','F','Interacting selectively and non-covalently with a type 5 melanocortin receptor.','2013-10-27','NSRP'),(15464,31784,'melatonin receptor binding','F','Interacting selectively and non-covalently with a melatonin receptor.','2013-10-27','NSRP'),(15465,31785,'type 1A melatonin receptor binding','F','Interacting selectively and non-covalently with a type 1A melatonin receptor.','2013-10-27','NSRP'),(15466,31786,'type 1B melatonin receptor binding','F','Interacting selectively and non-covalently with a type 1B melatonin receptor.','2013-10-27','NSRP'),(15467,31787,'H9 melatonin receptor binding','F','Interacting selectively and non-covalently with a H9 melatonin receptor.','2013-10-27','NSRP'),(15468,31788,'motilin receptor binding','F','Interacting selectively and non-covalently with a motilin receptor.','2013-10-27','NSRP'),(15469,31789,'G-protein coupled acetylcholine receptor binding','F','Interacting selectively and non-covalently with a G-protein coupled acetylcholine receptor.','2013-10-27','NSRP'),(15470,31790,'M1 muscarinic acetylcholine receptor binding','F','Interacting selectively and non-covalently with a M1 muscarinic acetylcholine receptor.','2012-03-14','NSRP'),(15471,31791,'M2 muscarinic acetylcholine receptor binding','F','Interacting selectively and non-covalently with a M2 muscarinic acetylcholine receptor.','2012-03-14','NSRP'),(15472,31792,'M3 muscarinic acetylcholine receptor binding','F','Interacting selectively and non-covalently with a M3 muscarinic acetylcholine receptor.','2012-03-14','NSRP'),(15473,31793,'M4 muscarinic acetylcholine receptor binding','F','Interacting selectively and non-covalently with a M4 muscarinic acetylcholine receptor.','2012-03-14','NSRP'),(15474,31794,'M5 muscarinic acetylcholine receptor binding','F','Interacting selectively and non-covalently with a M5 muscarinic acetylcholine receptor.','2012-03-14','NSRP'),(15475,31795,'G-protein coupled GABA receptor binding','F','Interacting selectively and non-covalently with a G-protein coupled (metabotropic) GABA receptor.','2013-10-27','NSRP'),(15476,31796,'type 1 metabotropic GABA receptor binding','F','Interacting selectively and non-covalently with a type 1 metabotropic GABA receptor.','2013-10-27','NSRP'),(15477,31797,'type 2 metabotropic GABA receptor binding','F','Interacting selectively and non-covalently with a type 2 metabotropic GABA receptor.','2013-10-27','NSRP'),(15478,31798,'type 1 metabotropic glutamate receptor binding','F','Interacting selectively and non-covalently with a type 1 metabotropic glutamate receptor.','2013-10-27','NSRP'),(15479,31799,'type 2 metabotropic glutamate receptor binding','F','Interacting selectively and non-covalently with a type 2 metabotropic glutamate receptor.','2013-10-27','NSRP'),(15480,31800,'type 3 metabotropic glutamate receptor binding','F','Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor.','2013-10-27','NSRP'),(15481,31801,'type 4 metabotropic glutamate receptor binding','F','Interacting selectively and non-covalently with a type 4 metabotropic glutamate receptor.','2013-10-27','NSRP'),(15482,31802,'type 5 metabotropic glutamate receptor binding','F','Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor.','2013-10-27','NSRP'),(15483,31803,'type 6 metabotropic glutamate receptor binding','F','Interacting selectively and non-covalently with a type 6 metabotropic glutamate receptor.','2013-10-27','NSRP'),(15484,31804,'type 7 metabotropic glutamate receptor binding','F','Interacting selectively and non-covalently with a type 7 metabotropic glutamate receptor.','2013-10-27','NSRP'),(15485,31805,'type 8 metabotropic glutamate receptor binding','F','Interacting selectively and non-covalently with a type 8 metabotropic glutamate receptor.','2013-10-27','NSRP'),(15486,31806,'G-protein coupled histamine receptor binding','F','Interacting selectively and non-covalently with a G-protein coupled (metabotropic) histamine receptor.','2013-10-27','NSRP'),(15487,31807,'H1 histamine receptor binding','F','Interacting selectively and non-covalently with a H1 histamine receptor.','2013-10-27','NSRP'),(15488,31808,'H2 histamine receptor binding','F','Interacting selectively and non-covalently with a H2 histamine receptor.','2013-10-27','NSRP'),(15489,31809,'H3 histamine receptor binding','F','Interacting selectively and non-covalently with a H3 histamine receptor.','2013-10-27','NSRP'),(15490,31810,'H4 histamine receptor binding','F','Interacting selectively and non-covalently with a H4 histamine receptor.','2013-10-27','NSRP'),(15491,31811,'G-protein coupled nucleotide receptor binding','F','Interacting selectively and non-covalently with a G-protein coupled (metabotropic) nucleotide receptor.','2013-10-27','NSRP'),(15492,31812,'P2Y1 nucleotide receptor binding','F','Interacting selectively and non-covalently with a P2Y1 nucleotide receptor.','2013-10-27','NSRP'),(15493,31813,'P2Y2 nucleotide receptor binding','F','Interacting selectively and non-covalently with a P2Y2 nucleotide receptor.','2013-10-27','NSRP'),(15494,31814,'P2Y4 nucleotide receptor binding','F','Interacting selectively and non-covalently with a P2Y4 nucleotide receptor.','2013-10-27','NSRP'),(15495,31815,'P2Y5 nucleotide receptor binding','F','Interacting selectively and non-covalently with a P2Y5 nucleotide receptor.','2013-10-27','NSRP'),(15496,31816,'P2Y6 nucleotide receptor binding','F','Interacting selectively and non-covalently with a P2Y6 nucleotide receptor.','2013-10-27','NSRP'),(15497,31817,'P2Y8 nucleotide receptor binding','F','Interacting selectively and non-covalently with a P2Y8 nucleotide receptor.','2013-10-27','NSRP'),(15498,31818,'P2Y9 nucleotide receptor binding','F','Interacting selectively and non-covalently with a P2Y9 nucleotide receptor.','2013-10-27','NSRP'),(15499,31819,'P2Y10 nucleotide receptor binding','F','Interacting selectively and non-covalently with a P2Y10 nucleotide receptor.','2013-10-27','NSRP'),(15500,31820,'P2Y11 nucleotide receptor binding','F','Interacting selectively and non-covalently with a P2Y11 nucleotide receptor.','2013-10-27','NSRP'),(15501,31821,'G-protein coupled serotonin receptor binding','F','Interacting selectively and non-covalently with a metabotropic serotonin receptor.','2013-10-27','NSRP'),(15502,31822,'type 1B serotonin receptor binding','F','Interacting selectively and non-covalently with a type 1B serotonin receptor.','2013-10-27','NSRP'),(15503,31823,'type 1D serotonin receptor binding','F','Interacting selectively and non-covalently with a type 1D serotonin receptor.','2013-10-27','NSRP'),(15504,31824,'type 1E serotonin receptor binding','F','Interacting selectively and non-covalently with a type 1E serotonin receptor.','2013-10-27','NSRP'),(15505,31825,'type 1F serotonin receptor binding','F','Interacting selectively and non-covalently with a type 1F serotonin receptor.','2013-10-27','NSRP'),(15506,31826,'type 2A serotonin receptor binding','F','Interacting selectively and non-covalently with a type 2A serotonin receptor.','2013-10-27','NSRP'),(15507,31827,'type 2B serotonin receptor binding','F','Interacting selectively and non-covalently with a type 2B serotonin receptor.','2013-10-27','NSRP'),(15508,31828,'type 2C serotonin receptor binding','F','Interacting selectively and non-covalently with a type 2C serotonin receptor.','2013-10-27','NSRP'),(15509,31829,'type 4 serotonin receptor binding','F','Interacting selectively and non-covalently with a type 4 serotonin receptor.','2013-10-27','NSRP'),(15510,31830,'type 5A serotonin receptor binding','F','Interacting selectively and non-covalently with a type 5A serotonin receptor.','2013-10-27','NSRP'),(15511,31831,'type 5B serotonin receptor binding','F','Interacting selectively and non-covalently with a type 5B serotonin receptor.','2013-10-27','NSRP'),(15512,31832,'type 6 serotonin receptor binding','F','Interacting selectively and non-covalently with a type 6 serotonin receptor.','2013-10-27','NSRP'),(15513,31833,'type 7 serotonin receptor binding','F','Interacting selectively and non-covalently with a type 7 serotonin receptor.','2013-10-27','NSRP'),(15514,31834,'neurokinin receptor binding','F','Interacting selectively and non-covalently with a neurokinin receptor.','2013-10-27','NSRP'),(15515,31835,'substance P receptor binding','F','Interacting selectively and non-covalently with a substance P receptor.','2013-10-27','NSRP'),(15516,31836,'neuromedin K receptor binding','F','Interacting selectively and non-covalently with a neuromedin K receptor.','2013-10-27','NSRP'),(15517,31837,'substance K receptor binding','F','Interacting selectively and non-covalently with a substance K receptor.','2013-10-27','NSRP'),(15518,31838,'haptoglobin-hemoglobin complex','C','A protein complex formed by the stable binding of a haptoglobin to hemoglobin.','2013-10-27','NSRP'),(15519,31839,'type 1 neuromedin U receptor binding','F','Interacting selectively and non-covalently with a type 1 neuromedin U receptor.','2013-10-27','NSRP'),(15520,31840,'type 2 neuromedin U receptor binding','F','Interacting selectively and non-covalently with a type 2 neuromedin U receptor.','2013-10-27','NSRP'),(15521,31841,'neuropeptide Y receptor binding','F','Interacting selectively and non-covalently with a neuropeptide Y receptor.','2013-10-27','NSRP'),(15522,31842,'type 1 neuropeptide Y receptor binding','F','Interacting selectively and non-covalently with a type 1 neuropeptide Y receptor.','2013-10-27','NSRP'),(15523,31843,'type 2 neuropeptide Y receptor binding','F','Interacting selectively and non-covalently with a type 2 neuropeptide Y receptor.','2013-10-27','NSRP'),(15524,31844,'type 4 neuropeptide Y receptor binding','F','Interacting selectively and non-covalently with a type 4 neuropeptide Y receptor.','2013-10-27','NSRP'),(15525,31845,'type 5 neuropeptide Y receptor binding','F','Interacting selectively and non-covalently with a type 5 neuropeptide Y receptor.','2013-10-27','NSRP'),(15526,31846,'neurotensin receptor binding','F','Interacting selectively and non-covalently with a neurotensin receptor.','2013-10-27','NSRP'),(15527,31847,'type 1 neurotensin receptor binding','F','Interacting selectively and non-covalently with a type 1 neurotensin receptor.','2013-10-27','NSRP'),(15528,31848,'protection from non-homologous end joining at telomere','P','A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse.','2013-10-27','NSRP'),(15529,31849,'olfactory receptor binding','F','Interacting selectively and non-covalently with an olfactory receptor.','2013-10-27','NSRP'),(15530,31850,'delta-type opioid receptor binding','F','Interacting selectively and non-covalently with a delta-type opioid receptor.','2013-10-27','NSRP'),(15531,31851,'kappa-type opioid receptor binding','F','Interacting selectively and non-covalently with a kappa-type opioid receptor.','2013-10-27','NSRP'),(15532,31852,'mu-type opioid receptor binding','F','Interacting selectively and non-covalently with a mu-type opioid receptor.','2013-10-27','NSRP'),(15533,31853,'nociceptin receptor binding','F','Interacting selectively and non-covalently with a nociceptin receptor.','2013-10-27','NSRP'),(15534,31854,'orexigenic neuropeptide QRFP receptor binding','F','Interacting selectively and non-covalently with an orexigenic neuropeptide QRFP receptor.','2013-10-27','NSRP'),(15535,31855,'oxytocin receptor binding','F','Interacting selectively and non-covalently with an oxytocin receptor.','2013-10-27','NSRP'),(15536,31856,'parathyroid hormone receptor binding','F','Interacting selectively and non-covalently with a parathyroid hormone receptor.','2013-10-27','NSRP'),(15537,31857,'type 1 parathyroid hormone receptor binding','F','Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor.','2013-10-27','NSRP'),(15538,31858,'pituitary adenylate cyclase-activating polypeptide receptor binding','F','Interacting selectively and non-covalently with a pituitary adenylate cyclase-activating polypeptide receptor.','2013-10-27','NSRP'),(15539,31859,'platelet activating factor receptor binding','F','Interacting selectively and non-covalently with a platelet activating factor receptor.','2013-10-27','NSRP'),(15540,31860,'telomeric 3\' overhang formation','P','The formation of the single stranded telomeric 3\' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans.','2013-10-27','NSRP'),(15541,31861,'prolactin-releasing peptide receptor binding','F','Interacting selectively and non-covalently with a prolactin-releasing peptide receptor.','2013-10-27','NSRP'),(15542,31862,'prostanoid receptor binding','F','Interacting selectively and non-covalently with a prostanoid receptor.','2013-10-27','NSRP'),(15543,31863,'prostaglandin D2 receptor binding','F','Interacting selectively and non-covalently with a prostaglandin D2 receptor.','2013-10-27','NSRP'),(15544,31864,'EP1 subtype prostaglandin E2 receptor binding','F','Interacting selectively and non-covalently with an EP1 subtype prostaglandin E2 receptor.','2013-10-27','NSRP'),(15545,31865,'EP2 subtype prostaglandin E2 receptor binding','F','Interacting selectively and non-covalently with an EP2 subtype prostaglandin E2 receptor.','2013-10-27','NSRP'),(15546,31866,'EP3 subtype prostaglandin E2 receptor binding','F','Interacting selectively and non-covalently with an EP3 subtype prostaglandin E2 receptor.','2013-10-27','NSRP'),(15547,31867,'EP4 subtype prostaglandin E2 receptor binding','F','Interacting selectively and non-covalently with an EP4 subtype prostaglandin E2 receptor.','2013-10-27','NSRP'),(15548,31868,'prostaglandin F2-alpha receptor binding','F','Interacting selectively and non-covalently with a prostaglandin F2-alpha receptor.','2013-10-27','NSRP'),(15549,31869,'prostacyclin receptor binding','F','Interacting selectively and non-covalently with a prostacyclin receptor.','2013-10-27','NSRP'),(15550,31870,'thromboxane A2 receptor binding','F','Interacting selectively and non-covalently with a thromboxane A2 receptor.','2013-10-27','NSRP'),(15551,31871,'proteinase activated receptor binding','F','Interacting selectively and non-covalently with a proteinase activated receptor.','2013-10-27','NSRP'),(15552,31872,'type 1 proteinase activated receptor binding','F','Interacting selectively and non-covalently with a type 1 proteinase activated receptor.','2013-10-27','NSRP'),(15553,31873,'type 2 proteinase activated receptor binding','F','Interacting selectively and non-covalently with a type 2 proteinase activated receptor.','2013-10-27','NSRP'),(15554,31874,'type 3 proteinase activated receptor binding','F','Interacting selectively and non-covalently with a type 3 proteinase activated receptor.','2013-10-27','NSRP'),(15555,31875,'type 4 proteinase activated receptor binding','F','Interacting selectively and non-covalently with a type 4 proteinase activated receptor.','2013-10-27','NSRP'),(15556,31876,'secretin receptor binding','F','Interacting selectively and non-covalently with a secretin receptor.','2013-10-27','NSRP'),(15557,31877,'somatostatin receptor binding','F','Interacting selectively and non-covalently with a somatostatin receptor.','2013-10-27','NSRP'),(15558,31878,'type 1 somatostatin receptor binding','F','Interacting selectively and non-covalently with a type 1 somatostatin receptor.','2013-10-27','NSRP'),(15559,31879,'type 2 somatostatin receptor binding','F','Interacting selectively and non-covalently with a type 2 somatostatin receptor.','2013-10-27','NSRP'),(15560,31880,'type 3 somatostatin receptor binding','F','Interacting selectively and non-covalently with a type 3 somatostatin receptor.','2013-10-27','NSRP'),(15561,31881,'type 4 somatostatin receptor binding','F','Interacting selectively and non-covalently with a type 4 somatostatin receptor.','2013-10-27','NSRP'),(15562,31882,'type 5 somatostatin receptor binding','F','Interacting selectively and non-covalently with a type 5 somatostatin receptor.','2013-10-27','NSRP'),(15563,31883,'taste receptor binding','F','Interacting selectively and non-covalently with a taste receptor.','2013-10-27','NSRP'),(15564,31884,'type 1 member 1 taste receptor binding','F','Interacting selectively and non-covalently with a type 1 member 1 taste receptor.','2013-10-27','NSRP'),(15565,31885,'type 1 member 2 taste receptor binding','F','Interacting selectively and non-covalently with a type 1 member 2 taste receptor.','2013-10-27','NSRP'),(15566,31886,'type 1 member 3 taste receptor binding','F','Interacting selectively and non-covalently with a type 1 member 3 taste receptor.','2013-10-27','NSRP'),(15567,31887,'lipid particle transport along microtubule','P','The directed movement of a lipid particle along a microtubule, mediated by motor proteins.','2013-10-27','NSRP'),(15568,31889,'urotensin receptor binding','F','Interacting selectively and non-covalently with a urotensin receptor.','2013-10-27','NSRP'),(15569,31890,'vasoactive intestinal polypeptide receptor binding','F','Interacting selectively and non-covalently with a vasoactive intestinal polypeptide receptor.','2013-10-27','NSRP'),(15570,31891,'type 1 vasoactive intestinal polypeptide receptor binding','F','Interacting selectively and non-covalently with a type 1 vasoactive intestinal polypeptide receptor.','2013-10-27','NSRP'),(15571,31892,'type 2 vasoactive intestinal polypeptide receptor binding','F','Interacting selectively and non-covalently with a type 2 vasoactive intestinal polypeptide receptor.','2013-10-27','NSRP'),(15572,31893,'vasopressin receptor binding','F','Interacting selectively and non-covalently with a vasopressin receptor.','2013-10-27','NSRP'),(15573,31894,'V1A vasopressin receptor binding','F','Interacting selectively and non-covalently with a V1A vasopressin receptor.','2013-10-27','NSRP'),(15574,31895,'V1B vasopressin receptor binding','F','Interacting selectively and non-covalently with a V1B vasopressin receptor.','2013-10-27','NSRP'),(15575,31896,'V2 vasopressin receptor binding','F','Interacting selectively and non-covalently with a V2 vasopressin receptor.','2013-10-27','NSRP'),(15576,31897,'Tic complex','C','The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane.','2013-10-27','NSRP'),(15577,31898,'chromoplast envelope','C','The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.','2013-10-27','NSRP'),(15578,31899,'chromoplast inner membrane','C','The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma.','2013-10-27','NSRP'),(15579,31900,'chromoplast outer membrane','C','The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope.','2013-10-27','NSRP'),(15580,31901,'early endosome membrane','C','The lipid bilayer surrounding an early endosome.','2013-10-27','NSRP'),(15581,31902,'late endosome membrane','C','The lipid bilayer surrounding a late endosome.','2013-10-27','NSRP'),(15582,31903,'microbody membrane','C','The lipid bilayer surrounding a microbody.','2013-10-27','NSRP'),(15583,31904,'endosome lumen','C','The volume enclosed by the membrane of an endosome.','2013-10-27','NSRP'),(15584,31905,'early endosome lumen','C','The volume enclosed by the membrane of an early endosome.','2013-10-27','NSRP'),(15585,31906,'late endosome lumen','C','The volume enclosed by the membrane of a late endosome.','2013-10-27','NSRP'),(15586,31907,'microbody lumen','C','The volume enclosed by the membranes of a microbody.','2013-10-27','NSRP'),(15587,31908,'glyoxysomal lumen','C','The volume enclosed by the membranes of a glyoxysome.','2013-10-27','NSRP'),(15588,31910,'cytostome','C','Stable, specialized structure for the ingestion of food by the cell into phagosomes.','2013-10-27','NSRP'),(15589,31911,'cytoproct','C','Stable, specialized structure for extrusion of waste by the cell into the surrounding medium.','2013-10-27','NSRP'),(15590,31912,'oral apparatus','C','Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems.','2013-10-27','NSRP'),(15591,31913,'contractile vacuole pore','C','Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium.','2013-10-27','NSRP'),(15592,31914,'negative regulation of synaptic plasticity','P','A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.','2013-10-27','NSRP'),(15593,31915,'positive regulation of synaptic plasticity','P','A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.','2013-10-27','NSRP'),(15594,31916,'regulation of synaptic metaplasticity','P','A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.','2013-10-27','NSRP'),(15595,31917,'negative regulation of synaptic metaplasticity','P','A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.','2013-10-27','NSRP'),(15596,31918,'positive regulation of synaptic metaplasticity','P','A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.','2013-10-27','NSRP'),(15597,31919,'vitamin B6 transport','P','The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15598,31920,'pyridoxal transport','P','The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.','2013-10-27','NSRP'),(15599,31921,'pyridoxal phosphate transport','P','The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6.','2013-10-27','NSRP'),(15600,31922,'pyridoxamine transport','P','The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.','2013-10-27','NSRP'),(15601,31923,'pyridoxine transport','P','The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.','2013-10-27','NSRP'),(15602,31924,'vitamin B6 transporter activity','F','Enables the directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells.','2013-10-27','NSRP'),(15603,31925,'pyridoxal transmembrane transporter activity','F','Enables the directed movement of pyridoxal across a membrane into, out of or within a cell, or between cells. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.','2013-10-27','NSRP'),(15604,31926,'pyridoxal phosphate transmembrane transporter activity','F','Enables the directed movement of pyridoxal phosphate into, out of or within a cell, or between cells; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6.','2013-10-27','NSRP'),(15605,31927,'pyridoxamine transmembrane transporter activity','F','Enables the directed movement of pyridoxamine into, out of or within a cell, or between cells. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.','2013-10-27','NSRP'),(15606,31928,'pyridoxine transmembrane transporter activity','F','Enables the directed movement of pyridoxine across a membrane into, out of or within a cell, or between cells. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.','2013-10-27','NSRP'),(15607,31929,'TOR signaling cascade','P','A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.','2013-10-27','NSRP'),(15608,31930,'mitochondria-nucleus signaling pathway','P','A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function.','2013-10-27','NSRP'),(15609,31931,'TORC1 complex','C','A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.','2013-10-27','NSRP'),(15610,31932,'TORC2 complex','C','A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.','2013-10-27','NSRP'),(15611,31933,'telomeric heterochromatin','C','Heterochromatic regions of the chromosome found at the telomeres.','2013-10-27','NSRP'),(15612,31934,'mating-type region heterochromatin','C','Heterochromatic regions of the chromosome found at silenced mating-type loci.','2013-10-27','NSRP'),(15613,31935,'regulation of chromatin silencing','P','Any process that affects the rate, extent or location of chromatin silencing.','2013-10-27','NSRP'),(15614,31936,'negative regulation of chromatin silencing','P','Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing.','2013-10-27','NSRP'),(15615,31937,'positive regulation of chromatin silencing','P','Any process that activates or increases the frequency, rate or extent of chromatin silencing.','2013-10-27','NSRP'),(15616,31938,'regulation of chromatin silencing at telomere','P','Any process that affects the rate, extent or location of chromatin silencing at telomeres.','2013-10-27','NSRP'),(15617,31939,'negative regulation of chromatin silencing at telomere','P','Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres.','2013-10-27','NSRP'),(15618,31940,'positive regulation of chromatin silencing at telomere','P','Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres.','2013-10-27','NSRP'),(15619,31941,'filamentous actin','C','A two-stranded helical polymer of the protein actin.','2013-10-27','NSRP'),(15620,31942,'i-AAA complex','C','Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases.','2013-10-27','NSRP'),(15621,31943,'regulation of glucocorticoid metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.','2013-10-27','NSRP'),(15622,31944,'negative regulation of glucocorticoid metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.','2013-10-27','NSRP'),(15623,31945,'positive regulation of glucocorticoid metabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.','2013-10-27','NSRP'),(15624,31946,'regulation of glucocorticoid biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.','2013-10-27','NSRP'),(15625,31947,'negative regulation of glucocorticoid biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.','2013-10-27','NSRP'),(15626,31948,'positive regulation of glucocorticoid biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.','2013-10-27','NSRP'),(15627,31949,'regulation of glucocorticoid catabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.','2013-10-27','NSRP'),(15628,31950,'negative regulation of glucocorticoid catabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.','2013-10-27','NSRP'),(15629,31951,'positive regulation of glucocorticoid catabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.','2013-10-27','NSRP'),(15630,31952,'regulation of protein autophosphorylation','P','Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.','2013-10-27','NSRP'),(15631,31953,'negative regulation of protein autophosphorylation','P','Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.','2013-10-27','NSRP'),(15632,31954,'positive regulation of protein autophosphorylation','P','Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.','2013-10-27','NSRP'),(15633,31955,'short-chain fatty acid-CoA ligase activity','F','Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6.','2013-10-27','NSRP'),(15634,31956,'medium-chain fatty acid-CoA ligase activity','F','Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12.','2013-10-27','NSRP'),(15635,31957,'very long-chain fatty acid-CoA ligase activity','F','Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22.','2013-10-27','NSRP'),(15636,31958,'corticosteroid receptor signaling pathway','P','Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor.','2013-10-27','NSRP'),(15637,31959,'mineralocorticoid receptor signaling pathway','P','Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor.','2013-10-27','NSRP'),(15638,31960,'response to corticosteroid stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.','2013-10-27','NSRP'),(15639,31961,'cortisol receptor binding','F','Interacting selectively and non-covalently with a cortisol receptor.','2013-10-27','NSRP'),(15640,31962,'mineralocorticoid receptor binding','F','Interacting selectively and non-covalently with a mineralocorticoid receptor.','2013-10-27','NSRP'),(15641,31963,'cortisol receptor activity','F','Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function.','2013-10-27','NSRP'),(15642,31964,'beta-alanyl-histamine hydrolase activity','F','Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine.','2013-10-27','NSRP'),(15643,31965,'nuclear membrane','C','Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.','2013-10-27','NSRP'),(15644,31966,'mitochondrial membrane','C','Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.','2013-10-27','NSRP'),(15645,31967,'organelle envelope','C','A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.','2013-10-27','NSRP'),(15646,31968,'organelle outer membrane','C','The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope.','2013-10-27','NSRP'),(15647,31969,'chloroplast membrane','C','Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope.','2013-10-27','NSRP'),(15648,31970,'organelle envelope lumen','C','The region between the inner and outer lipid bilayers of an organelle envelope.','2013-10-27','NSRP'),(15649,31972,'chloroplast intermembrane space','C','The region between the inner and outer lipid bilayers of a chloroplast envelope.','2013-10-27','NSRP'),(15650,31973,'chromoplast intermembrane space','C','The region between the inner and outer lipid bilayers of a chromoplast envelope.','2013-10-27','NSRP'),(15651,31974,'membrane-enclosed lumen','C','The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.','2013-10-27','NSRP'),(15652,31975,'envelope','C','A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.','2013-10-27','NSRP'),(15653,31976,'plastid thylakoid','C','Any thylakoid within a plastid.','2013-10-27','NSRP'),(15654,31977,'thylakoid lumen','C','The volume enclosed by a thylakoid membrane.','2013-10-27','NSRP'),(15655,31978,'plastid thylakoid lumen','C','The volume enclosed by a plastid thylakoid membrane.','2013-10-27','NSRP'),(15656,31979,'plasma membrane-derived thylakoid lumen','C','The volume enclosed by a plasma membrane-derived thylakoid.','2013-10-27','NSRP'),(15657,31981,'nuclear lumen','C','The volume enclosed by the nuclear inner membrane.','2013-10-27','NSRP'),(15658,31982,'vesicle','C','Any small, fluid-filled, spherical organelle enclosed by membrane or protein.','2013-10-27','NSRP'),(15659,31983,'vesicle lumen','C','The volume enclosed by the membrane or protein that forms a vesicle.','2013-10-27','NSRP'),(15660,31984,'organelle subcompartment','C','A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle.','2013-10-27','NSRP'),(15661,31985,'Golgi cisterna','C','Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.','2013-10-27','NSRP'),(15662,31986,'proteinoplast','C','A leucoplast in which protein is stored.','2013-10-27','NSRP'),(15663,31987,'locomotion involved in locomotory behavior','P','Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.','2013-10-27','NSRP'),(15664,31988,'membrane-bounded vesicle','C','Any small, fluid-filled, spherical organelle enclosed by a lipid bilayer.','2013-10-27','NSRP'),(15665,31989,'bombesin receptor signaling pathway','P','The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands.','2013-10-27','NSRP'),(15666,31990,'mRNA export from nucleus in response to heat stress','P','The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export.','2013-10-27','NSRP'),(15667,31991,'regulation of actomyosin contractile ring contraction','P','Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle.','2013-10-27','NSRP'),(15668,31992,'energy transducer activity','F','The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.','2013-10-27','NSRP'),(15669,31993,'light transducer activity','F','Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell.','2013-10-27','NSRP'),(15670,31994,'insulin-like growth factor I binding','F','Interacting selectively and non-covalently with insulin-like growth factor I.','2013-10-27','NSRP'),(15671,31995,'insulin-like growth factor II binding','F','Interacting selectively and non-covalently with insulin-like growth factor II.','2013-10-27','NSRP'),(15672,31996,'thioesterase binding','F','Interacting selectively and non-covalently with any thioesterase enzyme.','2013-10-27','NSRP'),(15673,31997,'N-terminal myristoylation domain binding','F','Interacting selectively and non-covalently with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin.','2013-10-27','NSRP'),(15674,31998,'regulation of fatty acid beta-oxidation','P','Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation.','2013-10-27','NSRP'),(15675,31999,'negative regulation of fatty acid beta-oxidation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation.','2013-10-27','NSRP'),(15676,32000,'positive regulation of fatty acid beta-oxidation','P','Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.','2013-10-27','NSRP'),(15677,32001,'1,4-alpha-glucan 6-alpha-glucosyltransferase activity','F','Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan.','2013-10-27','NSRP'),(15678,32002,'interleukin-28 receptor complex','C','A protein complex that binds interleukin-28 and interleukin-29. Composed of two subunits, IL-28R alpha and IL-10R beta.','2013-10-27','NSRP'),(15679,32003,'interleukin-28 receptor binding','F','Interacting selectively and non-covalently with the interleukin-28 receptor.','2013-10-27','NSRP'),(15680,32005,'signal transduction involved in conjugation with cellular fusion','P','The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion.','2013-10-27','NSRP'),(15681,32006,'regulation of TOR signaling cascade','P','Any process that modulates the frequency, rate or extent of signaling via the TOR signaling pathway.','2013-10-27','NSRP'),(15682,32007,'negative regulation of TOR signaling cascade','P','Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the TOR signaling pathway.','2013-10-27','NSRP'),(15683,32008,'positive regulation of TOR signaling cascade','P','Any process that activates or increases the frequency, rate or extent of signaling via the TOR signaling pathway.','2013-10-27','NSRP'),(15684,32009,'early phagosome','C','A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.','2013-10-27','NSRP'),(15685,32010,'phagolysosome','C','A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.','2013-10-27','NSRP'),(15686,32011,'ARF protein signal transduction','P','A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state.','2013-10-27','NSRP'),(15687,32012,'regulation of ARF protein signal transduction','P','Any process that modulates the frequency, rate or extent of ARF protein signal transduction.','2013-10-27','NSRP'),(15688,32013,'negative regulation of ARF protein signal transduction','P','Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction.','2013-10-27','NSRP'),(15689,32014,'positive regulation of ARF protein signal transduction','P','Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction.','2013-10-27','NSRP'),(15690,32015,'regulation of Ran protein signal transduction','P','Any process that modulates the frequency, rate or extent of Ran protein signal transduction.','2013-10-27','NSRP'),(15691,32016,'negative regulation of Ran protein signal transduction','P','Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction.','2013-10-27','NSRP'),(15692,32017,'positive regulation of Ran protein signal transduction','P','Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction.','2013-10-27','NSRP'),(15693,32018,'2-methylbutanol:NADP oxidoreductase activity','F','Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+.','2013-10-27','NSRP'),(15694,32019,'mitochondrial cloud','C','A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material.','2013-10-27','NSRP'),(15695,32020,'ISG15-protein conjugation','P','The covalent addition to a protein of ISG15, a ubiquitin-like protein.','2013-10-27','NSRP'),(15696,32021,'NELF complex','C','A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing.','2013-10-27','NSRP'),(15697,32022,'multicellular pellicle formation','P','A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface.','2013-10-27','NSRP'),(15698,32023,'trypsinogen activation','P','The proteolytic processing of trypsinogen to the active form, trypsin.','2013-10-27','NSRP'),(15699,32024,'positive regulation of insulin secretion','P','Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.','2013-10-27','NSRP'),(15700,32025,'response to cobalt ion','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.','2013-10-27','NSRP'),(15701,32026,'response to magnesium ion','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.','2013-10-27','NSRP'),(15702,32027,'myosin light chain binding','F','Interacting selectively and non-covalently with a light chain of a myosin complex.','2013-10-27','NSRP'),(15703,32028,'myosin head/neck binding','F','Interacting selectively and non-covalently with the head/neck region of a myosin heavy chain.','2013-10-27','NSRP'),(15704,32029,'myosin tail binding','F','Interacting selectively and non-covalently with the tail region of a myosin heavy chain.','2013-10-27','NSRP'),(15705,32030,'myosin I light chain binding','F','Interacting selectively and non-covalently with a light chain of a myosin I complex.','2013-10-27','NSRP'),(15706,32031,'myosin I head/neck binding','F','Interacting selectively and non-covalently with the head/neck region of a myosin I heavy chain.','2013-10-27','NSRP'),(15707,32032,'myosin I tail binding','F','Interacting selectively and non-covalently with the tail region of a myosin I heavy chain.','2013-10-27','NSRP'),(15708,32033,'myosin II light chain binding','F','Interacting selectively and non-covalently with a light chain of a myosin II complex.','2013-10-27','NSRP'),(15709,32034,'myosin II head/neck binding','F','Interacting selectively and non-covalently with the head/neck region of a myosin II heavy chain.','2013-10-27','NSRP'),(15710,32035,'myosin II tail binding','F','Interacting selectively and non-covalently with the tail region of a myosin II heavy chain.','2013-10-27','NSRP'),(15711,32036,'myosin heavy chain binding','F','Interacting selectively and non-covalently with a heavy chain of a myosin complex.','2013-10-27','NSRP'),(15712,32037,'myosin I heavy chain binding','F','Interacting selectively and non-covalently with a heavy chain of a myosin I complex.','2013-10-27','NSRP'),(15713,32038,'myosin II heavy chain binding','F','Interacting selectively and non-covalently with a heavy chain of a myosin II complex.','2013-10-27','NSRP'),(15714,32039,'integrator complex','C','A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3\'-end processing of small nuclear RNAs generated by RNA polymerase II.','2013-10-27','NSRP'),(15715,32040,'small-subunit processome','C','A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.','2013-10-27','NSRP'),(15716,32041,'NAD-dependent histone deacetylase activity (H3-K14 specific)','F','Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.','2013-10-27','NSRP'),(15717,32042,'mitochondrial DNA metabolic process','P','The chemical reactions and pathways involving mitochondrial DNA.','2013-10-27','NSRP'),(15718,32043,'mitochondrial DNA catabolic process','P','The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA.','2013-10-27','NSRP'),(15719,32044,'DSIF complex','C','A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.','2013-10-27','NSRP'),(15720,32045,'guanyl-nucleotide exchange factor complex','C','A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.','2013-10-27','NSRP'),(15721,32046,'micropexophagy-specific membrane apparatus','C','A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole.','2013-10-27','NSRP'),(15722,32047,'mitosome','C','A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria.','2013-10-27','NSRP'),(15723,32048,'cardiolipin metabolic process','P','The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.','2013-10-27','NSRP'),(15724,32049,'cardiolipin biosynthetic process','P','The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.','2013-10-27','NSRP'),(15725,32050,'clathrin heavy chain binding','F','Interacting selectively and non-covalently with a clathrin heavy chain.','2013-10-27','NSRP'),(15726,32051,'clathrin light chain binding','F','Interacting selectively and non-covalently with a clathrin light chain.','2013-10-27','NSRP'),(15727,32052,'bile acid binding','F','Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile.','2013-10-27','NSRP'),(15728,32053,'microtubule basal body organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum.','2013-10-27','NSRP'),(15729,32054,'microtubule basal body duplication','P','Construction of a new microtubule basal body.','2013-10-27','NSRP'),(15730,32055,'negative regulation of translation in response to stress','P','Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress.','2013-10-27','NSRP'),(15731,32056,'positive regulation of translation in response to stress','P','Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress.','2013-10-27','NSRP'),(15732,32057,'negative regulation of translational initiation in response to stress','P','Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.','2013-10-27','NSRP'),(15733,32058,'positive regulation of translational initiation in response to stress','P','Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.','2013-10-27','NSRP'),(15734,32059,'bleb','C','A cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions.','2013-10-27','NSRP'),(15735,32060,'bleb assembly','P','The assembly of a bleb, a cell extension characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusions.','2013-10-27','NSRP'),(15736,32061,'negative regulation of translation in response to osmotic stress','P','Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.','2013-10-27','NSRP'),(15737,32062,'positive regulation of translation in response to osmotic stress','P','Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.','2013-10-27','NSRP'),(15738,32063,'negative regulation of translational initiation in response to osmotic stress','P','Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.','2013-10-27','NSRP'),(15739,32064,'positive regulation of translational initiation in response to osmotic stress','P','Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.','2013-10-27','NSRP'),(15740,32065,'cortical protein anchoring','P','A process in which a protein or protein complex is maintained in a specific location in the cell cortex.','2013-10-27','NSRP'),(15741,32066,'nucleolus to nucleoplasm transport','P','The directed movement of substances from the nucleolus to the nucleoplasm.','2013-10-27','NSRP'),(15742,32067,'Type IV site-specific deoxyribonuclease activity','F','Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated).','2013-10-27','NSRP'),(15743,32068,'Type IV site-specific deoxyribonuclease complex','C','A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation.','2013-10-27','NSRP'),(15744,32069,'regulation of nuclease activity','P','Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.','2013-10-27','NSRP'),(15745,32070,'regulation of deoxyribonuclease activity','P','Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.','2013-10-27','NSRP'),(15746,32071,'regulation of endodeoxyribonuclease activity','P','Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.','2013-10-27','NSRP'),(15747,32072,'regulation of restriction endodeoxyribonuclease activity','P','Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.','2013-10-27','NSRP'),(15748,32073,'negative regulation of restriction endodeoxyribonuclease activity','P','Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.','2013-10-27','NSRP'),(15749,32074,'negative regulation of nuclease activity','P','Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids.','2013-10-27','NSRP'),(15750,32075,'positive regulation of nuclease activity','P','Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.','2013-10-27','NSRP'),(15751,32076,'negative regulation of deoxyribonuclease activity','P','Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.','2013-10-27','NSRP'),(15752,32077,'positive regulation of deoxyribonuclease activity','P','Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.','2013-10-27','NSRP'),(15753,32078,'negative regulation of endodeoxyribonuclease activity','P','Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.','2013-10-27','NSRP'),(15754,32079,'positive regulation of endodeoxyribonuclease activity','P','Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.','2013-10-27','NSRP'),(15755,32080,'negative regulation of Type I site-specific deoxyribonuclease activity','P','Any process that stops or reduces the rate of Type I restriction endodeoxyribonuclease activity.','2013-10-27','NSRP'),(15756,32081,'negative regulation of Type II site-specific deoxyribonuclease activity','P','Any process that stops or reduces the rate of Type II restriction endodeoxyribonuclease activity.','2013-10-27','NSRP'),(15757,32082,'negative regulation of Type III site-specific deoxyribonuclease activity','P','Any process that stops or reduces the rate of Type III restriction endodeoxyribonuclease activity.','2013-10-27','NSRP'),(15758,32083,'negative regulation of Type IV site-specific deoxyribonuclease activity','P','Any process that stops or reduces the rate of Type IV restriction endodeoxyribonuclease activity.','2013-10-27','NSRP'),(15759,32084,'regulation of Type I site-specific deoxyribonuclease activity','P','Any process that modulates the frequency, rate or extent of a Type I restriction endodeoxyribonuclease activity.','2013-10-27','NSRP'),(15760,32085,'regulation of Type II site-specific deoxyribonuclease activity','P','Any process that modulates the frequency, rate or extent of a Type II restriction endodeoxyribonuclease activity.','2013-10-27','NSRP'),(15761,32086,'regulation of Type III site-specific deoxyribonuclease activity','P','Any process that modulates the frequency, rate or extent of a Type III restriction endodeoxyribonuclease activity.','2013-10-27','NSRP'),(15762,32087,'regulation of Type IV site-specific deoxyribonuclease activity','P','Any process that modulates the frequency, rate or extent of a Type IV restriction endodeoxyribonuclease activity.','2013-10-27','NSRP'),(15763,32088,'negative regulation of NF-kappaB transcription factor activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.','2013-10-27','NSRP'),(15764,32089,'NACHT domain binding','F','Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs.','2013-10-27','NSRP'),(15765,32090,'Pyrin domain binding','F','Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.','2013-10-27','NSRP'),(15766,32091,'negative regulation of protein binding','P','Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.','2013-10-27','NSRP'),(15767,32092,'positive regulation of protein binding','P','Any process that activates or increases the frequency, rate or extent of protein binding.','2013-10-27','NSRP'),(15768,32093,'SAM domain binding','F','Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes.','2013-10-27','NSRP'),(15769,32094,'response to food','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.','2013-10-27','NSRP'),(15770,32095,'regulation of response to food','P','Any process that modulates the frequency, rate or extent of a response to a food stimulus.','2013-10-27','NSRP'),(15771,32096,'negative regulation of response to food','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus.','2013-10-27','NSRP'),(15772,32097,'positive regulation of response to food','P','Any process that activates, maintains, or increases the rate of a response to a food stimulus.','2013-10-27','NSRP'),(15773,32098,'regulation of appetite','P','Any process which modulates appetite, the desire or physical craving for food.','2013-10-27','NSRP'),(15774,32099,'negative regulation of appetite','P','Any process that reduces appetite.','2013-10-27','NSRP'),(15775,32100,'positive regulation of appetite','P','Any process that increases appetite.','2013-10-27','NSRP'),(15776,32101,'regulation of response to external stimulus','P','Any process that modulates the frequency, rate or extent of a response to an external stimulus.','2013-10-27','NSRP'),(15777,32102,'negative regulation of response to external stimulus','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.','2013-10-27','NSRP'),(15778,32103,'positive regulation of response to external stimulus','P','Any process that activates, maintains or increases the rate of a response to an external stimulus.','2013-10-27','NSRP'),(15779,32104,'regulation of response to extracellular stimulus','P','Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus.','2013-10-27','NSRP'),(15780,32105,'negative regulation of response to extracellular stimulus','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus.','2013-10-27','NSRP'),(15781,32106,'positive regulation of response to extracellular stimulus','P','Any process that activates, maintains or increases the rate of a response to an extracellular stimulus.','2013-10-27','NSRP'),(15782,32107,'regulation of response to nutrient levels','P','Any process that modulates the frequency, rate or extent of a response to nutrient levels.','2013-10-27','NSRP'),(15783,32108,'negative regulation of response to nutrient levels','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels.','2013-10-27','NSRP'),(15784,32109,'positive regulation of response to nutrient levels','P','Any process that activates or increases the frequency, rate or extent of a response to nutrient levels.','2013-10-27','NSRP'),(15785,32110,'regulation of protein histidine kinase activity','P','Any process that modulates the frequency, rate or extent of protein histidine kinase activity.','2013-10-27','NSRP'),(15786,32111,'activation of protein histidine kinase activity','P','Any process that initiates the activity of an inactive protein histidine kinase.','2013-10-27','NSRP'),(15787,32112,'negative regulation of protein histidine kinase activity','P','Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity.','2013-10-27','NSRP'),(15788,32113,'regulation of carbohydrate phosphatase activity','P','Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate.','2013-10-27','NSRP'),(15789,32114,'regulation of glucose-6-phosphatase activity','P','Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate.','2013-10-27','NSRP'),(15790,32115,'sorbose reductase activity','F','Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction.','2013-10-27','NSRP'),(15791,32116,'SMC loading complex','C','A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved.','2013-10-27','NSRP'),(15792,32117,'horsetail-astral microtubule array','C','An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement.','2013-10-27','NSRP'),(15793,32118,'horsetail-astral microtubule organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis.','2013-10-27','NSRP'),(15794,32119,'sequestering of zinc ion','P','The process of binding or confining zinc ions such that they are separated from other components of a biological system.','2013-10-27','NSRP'),(15795,32120,'ascospore-type prospore membrane assembly','P','The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed.','2013-10-27','NSRP'),(15796,32121,'attachment of telomeric heterochromatin to spindle pole body','P','The cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation.','2013-10-27','NSRP'),(15797,32122,'oral apparatus organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans.','2013-10-27','NSRP'),(15798,32123,'deep fiber','C','Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm.','2013-10-27','NSRP'),(15799,32124,'macronucleus organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus.','2013-10-27','NSRP'),(15800,32125,'micronucleus organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus.','2013-10-27','NSRP'),(15801,32126,'eisosome','C','A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization.','2013-10-27','NSRP'),(15802,32127,'dense core granule membrane','C','The lipid bilayer surrounding a dense core granule.','2013-10-27','NSRP'),(15803,32128,'flocculation via extracellular polymer','P','Non-sexual aggregation of single-celled organisms mediated by polymers (polysaccharides, proteins, and/or nucleic acids) secreted into the extracellular environment.','2013-10-27','NSRP'),(15804,32129,'histone deacetylase activity (H3-K9 specific)','F','Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.','2013-10-27','NSRP'),(15805,32130,'medial membrane band assembly','P','The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring.','2013-10-27','NSRP'),(15806,32131,'alkylated DNA binding','F','Interacting selectively and non-covalently with alkylated residues in DNA.','2013-10-27','NSRP'),(15807,32132,'O6-alkylguanine-DNA binding','F','Interacting selectively and non-covalently with O6-alkylguanine adducts in DNA.','2013-10-27','NSRP'),(15808,32133,'chromosome passenger complex','C','A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin.','2013-10-27','NSRP'),(15809,32135,'DNA insertion or deletion binding','F','Interacting selectively and non-covalently with double-stranded DNA containing insertions or deletions.','2013-10-27','NSRP'),(15810,32136,'adenine/cytosine mispair binding','F','Interacting selectively and non-covalently with double-stranded DNA containing an A/C mispair.','2013-10-27','NSRP'),(15811,32137,'guanine/thymine mispair binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair.','2013-10-27','NSRP'),(15812,32138,'single base insertion or deletion binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion.','2013-10-27','NSRP'),(15813,32139,'dinucleotide insertion or deletion binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion.','2013-10-27','NSRP'),(15814,32140,'single adenine insertion binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a single adenine insertion or a deletion that results in an unpaired adenine.','2013-10-27','NSRP'),(15815,32141,'single cytosine insertion binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a single cytosine insertion or a deletion that results in an unpaired cytosine.','2013-10-27','NSRP'),(15816,32142,'single guanine insertion binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine.','2013-10-27','NSRP'),(15817,32143,'single thymine insertion binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine.','2013-10-27','NSRP'),(15818,32144,'4-aminobutyrate transaminase complex','C','A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity.','2013-10-27','NSRP'),(15819,32145,'succinate-semialdehyde dehydrogenase binding','F','Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase.','2013-10-27','NSRP'),(15820,32146,'thiosulfate transmembrane-transporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiosulfate(out) = ADP + phosphate + thiosulfate(in).','2013-10-27','NSRP'),(15821,32147,'activation of protein kinase activity','P','Any process that initiates the activity of an inactive protein kinase.','2013-10-27','NSRP'),(15822,32148,'activation of protein kinase B activity','P','Any process that initiates the activity of the inactive enzyme protein kinase B.','2013-10-27','NSRP'),(15823,32149,'response to rhamnose stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus.','2013-10-27','NSRP'),(15824,32150,'ubiquinone biosynthetic process from chorismate','P','The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate.','2013-10-27','NSRP'),(15825,32151,'mitotic septin complex','C','A heterooligomeric septin complex that acts during mitotic cell division.','2013-10-27','NSRP'),(15826,32152,'meiotic septin complex','C','A heterooligomeric septin complex that acts during meiotic cell division.','2013-10-27','NSRP'),(15827,32153,'cell division site','C','The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.','2013-10-27','NSRP'),(15828,32154,'cleavage furrow','C','In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term \'cleavage furrow\' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists.','2013-10-27','NSRP'),(15829,32155,'cell division site part','C','Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell.','2013-10-27','NSRP'),(15830,32156,'septin cytoskeleton','C','The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes.','2013-10-27','NSRP'),(15831,32157,'prospore contractile ring','C','A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis.','2013-10-27','NSRP'),(15832,32158,'septin band','C','A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously.','2013-10-27','NSRP'),(15833,32159,'septin cap','C','A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.','2013-10-27','NSRP'),(15834,32160,'septin filament array','C','Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans.','2013-10-27','NSRP'),(15835,32161,'cleavage apparatus septin structure','C','Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis.','2013-10-27','NSRP'),(15836,32162,'mating projection septin band','C','A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection).','2013-10-27','NSRP'),(15837,32163,'hyphal septin band','C','A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously.','2013-10-27','NSRP'),(15838,32164,'hyphal septin cap','C','A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.','2013-10-27','NSRP'),(15839,32165,'prospore septin filament array','C','Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation.','2013-10-27','NSRP'),(15840,32166,'chlamydospore septin filament array','C','Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation.','2013-10-27','NSRP'),(15841,32167,'septin patch','C','OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis.','2013-10-27','NSRP'),(15842,32168,'hyphal septin ring','C','A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins.','2013-10-27','NSRP'),(15843,32169,'prospore septin ring','C','A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins.','2013-10-27','NSRP'),(15844,32170,'pseudohyphal septin ring','C','A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins.','2013-10-27','NSRP'),(15845,32171,'germ tube septin cap','C','A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.','2013-10-27','NSRP'),(15846,32172,'germ tube septin ring','C','A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins.','2013-10-27','NSRP'),(15847,32173,'septin collar','C','A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell.','2013-10-27','NSRP'),(15848,32174,'cellular bud neck septin collar','C','A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck.','2013-10-27','NSRP'),(15849,32175,'mating projection septin ring','C','A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip.','2013-10-27','NSRP'),(15850,32176,'split septin rings','C','A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well.','2013-10-27','NSRP'),(15851,32177,'cellular bud neck split septin rings','C','Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated.','2013-10-27','NSRP'),(15852,32178,'medial membrane band','C','A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum.','2013-10-27','NSRP'),(15853,32179,'germ tube','C','The slender tubular outgrowth first produced by most spores in germination.','2013-10-27','NSRP'),(15854,32180,'ubiquinone biosynthetic process from tyrosine','P','The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate.','2013-10-27','NSRP'),(15855,32181,'dinucleotide repeat insertion binding','F','Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats.','2013-10-27','NSRP'),(15856,32182,'small conjugating protein binding','F','Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein.','2013-10-27','NSRP'),(15857,32183,'SUMO binding','F','Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO.','2013-10-27','NSRP'),(15858,32184,'SUMO polymer binding','F','Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO.','2013-10-27','NSRP'),(15859,32185,'septin cytoskeleton organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins.','2013-10-27','NSRP'),(15860,32186,'cellular bud neck septin ring organization','P','Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck.','2013-10-27','NSRP'),(15861,32187,'actomyosin contractile ring localization','P','The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle.','2013-10-27','NSRP'),(15862,32188,'establishment of actomyosin contractile ring localization','P','The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis.','2013-10-27','NSRP'),(15863,32189,'maintenance of actomyosin contractile ring localization','P','Any process in which a contractile ring is maintained in a location and prevented from moving elsewhere.','2013-10-27','NSRP'),(15864,32190,'acrosin binding','F','Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities.','2013-10-27','NSRP'),(15865,32191,'acrosin heavy chain binding','F','Interacting selectively and non-covalently with the larger of the two covalently linked polypeptide chains of acrosin.','2012-03-14','NSRP'),(15866,32192,'acrosin light chain binding','F','Interacting selectively and non-covalently with the smaller of the two covalently linked polypeptide chains of acrosin.','2012-03-14','NSRP'),(15867,32193,'ubiquinone biosynthetic process via 2-polyprenylphenol','P','The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol.','2013-10-27','NSRP'),(15868,32194,'ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate','P','The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate.','2013-10-27','NSRP'),(15869,32195,'post-lysosomal vacuole','C','A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis.','2013-10-27','NSRP'),(15870,32196,'transposition','P','Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites.','2013-10-27','NSRP'),(15871,32197,'transposition, RNA-mediated','P','Any process involved in a type of transpositional recombination which occurs via an RNA intermediate.','2013-10-27','NSRP'),(15872,32198,'MITE transposition','P','Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs).','2013-10-27','NSRP'),(15873,32199,'reverse transcription involved in RNA-mediated transposition','P','The synthesis of DNA from an RNA transposon intermediate.','2013-10-27','NSRP'),(15874,32200,'telomere organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.','2013-10-27','NSRP'),(15875,32201,'telomere maintenance via semi-conservative replication','P','The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors.','2013-10-27','NSRP'),(15876,32202,'telomere assembly','P','A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins.','2013-10-27','NSRP'),(15877,32203,'telomere formation via telomerase','P','The addition of telomeric repeats to a non-telomeric double-stranded DNA end by telomerase.','2013-10-27','NSRP'),(15878,32204,'regulation of telomere maintenance','P','Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.','2013-10-27','NSRP'),(15879,32205,'negative regulation of telomere maintenance','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.','2013-10-27','NSRP'),(15880,32206,'positive regulation of telomere maintenance','P','Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.','2013-10-27','NSRP'),(15881,32207,'regulation of telomere maintenance via recombination','P','Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.','2013-10-27','NSRP'),(15882,32208,'negative regulation of telomere maintenance via recombination','P','Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.','2013-10-27','NSRP'),(15883,32209,'positive regulation of telomere maintenance via recombination','P','Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.','2013-10-27','NSRP'),(15884,32210,'regulation of telomere maintenance via telomerase','P','Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase.','2013-10-27','NSRP'),(15885,32211,'negative regulation of telomere maintenance via telomerase','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.','2013-10-27','NSRP'),(15886,32212,'positive regulation of telomere maintenance via telomerase','P','Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.','2013-10-27','NSRP'),(15887,32213,'regulation of telomere maintenance via semi-conservative replication','P','Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA.','2013-10-27','NSRP'),(15888,32214,'negative regulation of telomere maintenance via semi-conservative replication','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA.','2013-10-27','NSRP'),(15889,32215,'positive regulation of telomere maintenance via semi-conservative replication','P','Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA.','2013-10-27','NSRP'),(15890,32216,'glucosaminyl-phosphotidylinositol O-acyltransferase activity','F','Catalysis of the reaction: glucosaminyl-phosphotidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phosphotidylinositol + CoA.','2013-10-27','NSRP'),(15891,32217,'riboflavin transporter activity','F','Facilitates the directed movement of riboflavin into, out of or within a cell, or between cells. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins.','2013-10-27','NSRP'),(15892,32218,'riboflavin transport','P','The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins.','2013-10-27','NSRP'),(15893,32219,'cell wall macromolecule catabolic process involved in cytogamy','P','The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy.','2013-10-27','NSRP'),(15894,32220,'plasma membrane fusion involved in cytogamy','P','The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy.','2013-10-27','NSRP'),(15895,32221,'Rpd3S complex','C','A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).','2013-10-27','NSRP'),(15896,32222,'regulation of synaptic transmission, cholinergic','P','Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.','2013-10-27','NSRP'),(15897,32223,'negative regulation of synaptic transmission, cholinergic','P','Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.','2013-10-27','NSRP'),(15898,32224,'positive regulation of synaptic transmission, cholinergic','P','Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.','2013-10-27','NSRP'),(15899,32225,'regulation of synaptic transmission, dopaminergic','P','Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.','2013-10-27','NSRP'),(15900,32226,'positive regulation of synaptic transmission, dopaminergic','P','Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.','2013-10-27','NSRP'),(15901,32227,'negative regulation of synaptic transmission, dopaminergic','P','Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.','2013-10-27','NSRP'),(15902,32228,'regulation of synaptic transmission, GABAergic','P','Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).','2013-10-27','NSRP'),(15903,32229,'negative regulation of synaptic transmission, GABAergic','P','Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).','2013-10-27','NSRP'),(15904,32230,'positive regulation of synaptic transmission, GABAergic','P','Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).','2013-10-27','NSRP'),(15905,32231,'regulation of actin filament bundle assembly','P','Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.','2013-10-27','NSRP'),(15906,32232,'negative regulation of actin filament bundle assembly','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles.','2013-10-27','NSRP'),(15907,32233,'positive regulation of actin filament bundle assembly','P','Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.','2013-10-27','NSRP'),(15908,32234,'regulation of calcium ion transport via store-operated calcium channel activity','P','OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel.','2013-10-27','NSRP'),(15909,32235,'negative regulation of calcium ion transport via store-operated calcium channel activity','P','OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel.','2013-10-27','NSRP'),(15910,32236,'positive regulation of calcium ion transport via store-operated calcium channel activity','P','OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel.','2013-10-27','NSRP'),(15911,32237,'activation of store-operated calcium channel activity','P','A process that initiates the activity of an inactive store-operated calcium channel.','2013-10-27','NSRP'),(15912,32238,'adenosine transport','P','The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15913,32239,'regulation of nucleobase-containing compound transport','P','Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15914,32240,'negative regulation of nucleobase-containing compound transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15915,32241,'positive regulation of nucleobase-containing compound transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15916,32242,'regulation of nucleoside transport','P','Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15917,32243,'negative regulation of nucleoside transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15918,32244,'positive regulation of nucleoside transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15919,32245,'regulation of purine nucleoside transport','P','Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15920,32246,'regulation of pyrimidine nucleoside transport','P','Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15921,32247,'negative regulation of purine nucleoside transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15922,32248,'positive regulation of purine nucleoside transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15923,32249,'regulation of adenosine transport','P','Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15924,32250,'negative regulation of adenosine transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15925,32251,'positive regulation of adenosine transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(15926,32252,'secretory granule localization','P','Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.','2013-10-27','NSRP'),(15927,32253,'dense core granule localization','P','Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell.','2013-10-27','NSRP'),(15928,32254,'establishment of secretory granule localization','P','The directed movement of a secretory granule to a specific location.','2013-10-27','NSRP'),(15929,32255,'maintenance of secretory granule location','P','Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere.','2013-10-27','NSRP'),(15930,32256,'establishment of dense core granule localization','P','The directed movement of a dense core granule to a specific location.','2013-10-27','NSRP'),(15931,32257,'maintenance of dense core granule location','P','Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere.','2013-10-27','NSRP'),(15932,32258,'CVT pathway','P','A constitutive biosynthetic process that occurs under nutrient-rich conditions, in which two resident vacuolar hydrolases, aminopeptidase I and alpha-mannosidase, are sequestered into vesicles; these vesicles are transported to, and then fuse with, the vacuole. This pathway is mostly observed in yeast.','2013-10-27','NSRP'),(15933,32259,'methylation','P','The process in which a methyl group is covalently attached to a molecule.','2013-10-27','NSRP'),(15934,32260,'response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen.','2013-10-27','NSRP'),(15935,32261,'purine nucleotide salvage','P','Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(15936,32262,'pyrimidine nucleotide salvage','P','Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(15937,32263,'GMP salvage','P','Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(15938,32264,'IMP salvage','P','Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(15939,32265,'XMP salvage','P','Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis.','2013-10-27','NSRP'),(15940,32266,'phosphatidylinositol-3-phosphate binding','F','Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3\' position.','2013-10-27','NSRP'),(15941,32267,'tRNA(Ile)-lysidine synthase activity','F','Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine.','2013-10-27','NSRP'),(15942,32268,'regulation of cellular protein metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.','2013-10-27','NSRP'),(15943,32269,'negative regulation of cellular protein metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.','2013-10-27','NSRP'),(15944,32270,'positive regulation of cellular protein metabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.','2013-10-27','NSRP'),(15945,32271,'regulation of protein polymerization','P','Any process that modulates the frequency, rate or extent of the process of creating protein polymers.','2013-10-27','NSRP'),(15946,32272,'negative regulation of protein polymerization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.','2013-10-27','NSRP'),(15947,32273,'positive regulation of protein polymerization','P','Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.','2013-10-27','NSRP'),(15948,32274,'gonadotropin secretion','P','The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone.','2013-10-27','NSRP'),(15949,32275,'luteinizing hormone secretion','P','The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.','2013-10-27','NSRP'),(15950,32276,'regulation of gonadotropin secretion','P','Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin.','2013-10-27','NSRP'),(15951,32277,'negative regulation of gonadotropin secretion','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin.','2013-10-27','NSRP'),(15952,32278,'positive regulation of gonadotropin secretion','P','Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin.','2013-10-27','NSRP'),(15953,32279,'asymmetric synapse','C','A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density.','2013-10-27','NSRP'),(15954,32280,'symmetric synapse','C','A type of synapse occurring primarily on dendrite shafts and neuronal cell bodies. Symmetric synapses involve axons containing clusters of predominantly flattened or elongated vesicles and do not contain a prominent postsynaptic density.','2013-10-27','NSRP'),(15955,32281,'alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex','C','An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.','2013-10-27','NSRP'),(15956,32282,'plastid acetyl-CoA carboxylase complex','C','An acetyl-CoA carboxylase complex located in the stroma of a plastid.','2013-10-27','NSRP'),(15957,32283,'plastid acetate CoA-transferase complex','C','An acetate CoA-transferase complex located in the stroma of a plastid.','2013-10-27','NSRP'),(15958,32284,'plastid biotin carboxylase complex','C','A biotin carboxylase complex located in the stroma of a plastid.','2013-10-27','NSRP'),(15959,32285,'non-myelinated axon ensheathment','P','The process in which a non-myelinating glial cell membrane closes around an axon.','2013-10-27','NSRP'),(15960,32286,'central nervous system myelin maintenance','P','The process in which the structure and material content of mature central nervous system myelin is kept in a functional state.','2013-10-27','NSRP'),(15961,32287,'peripheral nervous system myelin maintenance','P','The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state.','2013-10-27','NSRP'),(15962,32288,'myelin assembly','P','The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.','2013-10-27','NSRP'),(15963,32289,'central nervous system myelin formation','P','The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.','2013-10-27','NSRP'),(15964,32290,'peripheral nervous system myelin formation','P','The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the peripheral nervous system.','2013-10-27','NSRP'),(15965,32291,'axon ensheathment in central nervous system','P','The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.','2013-10-27','NSRP'),(15966,32292,'peripheral nervous system axon ensheathment','P','The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.','2013-10-27','NSRP'),(15967,32293,'non-myelinated axon ensheathment in central nervous system','P','The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system.','2013-10-27','NSRP'),(15968,32294,'peripheral nervous system non-myelinated axon ensheathment','P','The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons.','2013-10-27','NSRP'),(15969,32295,'ensheathment of neuronal cell bodies','P','The process in which satellite glial cells isolate neuronal cell bodies.','2013-10-27','NSRP'),(15970,32296,'double-stranded RNA-specific ribonuclease activity','F','Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules.','2013-10-27','NSRP'),(15971,32297,'negative regulation of DNA-dependent DNA replication initiation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.','2013-10-27','NSRP'),(15972,32298,'positive regulation of DNA-dependent DNA replication initiation','P','Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication.','2013-10-27','NSRP'),(15973,32299,'ribonuclease H2 complex','C','A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p.','2013-10-27','NSRP'),(15974,32300,'mismatch repair complex','C','Any complex formed of proteins that act in mismatch repair.','2013-10-27','NSRP'),(15975,32301,'MutSalpha complex','C','A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.','2013-10-27','NSRP'),(15976,32302,'MutSbeta complex','C','A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3.','2013-10-27','NSRP'),(15977,32303,'regulation of icosanoid secretion','P','Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell.','2013-10-27','NSRP'),(15978,32304,'negative regulation of icosanoid secretion','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell.','2013-10-27','NSRP'),(15979,32305,'positive regulation of icosanoid secretion','P','Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell.','2013-10-27','NSRP'),(15980,32306,'regulation of prostaglandin secretion','P','Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell.','2013-10-27','NSRP'),(15981,32307,'negative regulation of prostaglandin secretion','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell.','2013-10-27','NSRP'),(15982,32308,'positive regulation of prostaglandin secretion','P','Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell.','2013-10-27','NSRP'),(15983,32309,'icosanoid secretion','P','The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue.','2013-10-27','NSRP'),(15984,32310,'prostaglandin secretion','P','The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue.','2013-10-27','NSRP'),(15985,32311,'angiogenin-PRI complex','C','A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis.','2013-10-27','NSRP'),(15986,32312,'regulation of ARF GTPase activity','P','Any process that modulates the activity of the GTPase ARF.','2013-10-27','NSRP'),(15987,32313,'regulation of Rab GTPase activity','P','Any process that modulates the activity of a GTPase of the Rab family.','2013-10-27','NSRP'),(15988,32314,'regulation of Rac GTPase activity','P','Any process that modulates the activity of a GTPase of the Rac family.','2013-10-27','NSRP'),(15989,32315,'regulation of Ral GTPase activity','P','Any process that modulates the activity of a GTPase of the Ral family.','2013-10-27','NSRP'),(15990,32316,'regulation of Ran GTPase activity','P','Any process that modulates the activity of a GTPase of the Ran family.','2013-10-27','NSRP'),(15991,32317,'regulation of Rap GTPase activity','P','Any process that modulates the activity of a GTPase of the Rap family.','2013-10-27','NSRP'),(15992,32318,'regulation of Ras GTPase activity','P','Any process that modulates the activity of a GTPase of the Ras superfamily.','2013-10-27','NSRP'),(15993,32319,'regulation of Rho GTPase activity','P','Any process that modulates the activity of a GTPase of the Rho family.','2013-10-27','NSRP'),(15994,32320,'positive regulation of Ras GTPase activity','P','Any process that activates or increases the activity of a GTPase of the Ras superfamily.','2013-10-27','NSRP'),(15995,32321,'positive regulation of Rho GTPase activity','P','Any process that activates or increases the activity of a GTPase of the Rho family.','2013-10-27','NSRP'),(15996,32322,'ubiquinone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme.','2013-10-27','NSRP'),(15997,32323,'lipoate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of lipoate.','2013-10-27','NSRP'),(15998,32324,'molybdopterin cofactor biosynthetic process','P','The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.','2013-10-27','NSRP'),(15999,32325,'molybdopterin cofactor catabolic process','P','The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.','2013-10-27','NSRP'),(16000,32326,'Mo-molybdopterin cofactor catabolic process','P','The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.','2013-10-27','NSRP'),(16001,32327,'W-molybdopterin cofactor catabolic process','P','The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.','2013-10-27','NSRP'),(16002,32328,'alanine transport','P','The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16003,32329,'serine transport','P','The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16004,32330,'regulation of chondrocyte differentiation','P','Any process that modulates the frequency, rate or extent of chondrocyte differentiation.','2013-10-27','NSRP'),(16005,32331,'negative regulation of chondrocyte differentiation','P','Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.','2013-10-27','NSRP'),(16006,32332,'positive regulation of chondrocyte differentiation','P','Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.','2013-10-27','NSRP'),(16007,32333,'activin secretion','P','The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone.','2013-10-27','NSRP'),(16008,32334,'inhibin secretion','P','The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone.','2013-10-27','NSRP'),(16009,32335,'regulation of activin secretion','P','Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell.','2013-10-27','NSRP'),(16010,32336,'negative regulation of activin secretion','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell.','2013-10-27','NSRP'),(16011,32337,'positive regulation of activin secretion','P','Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell.','2013-10-27','NSRP'),(16012,32338,'regulation of inhibin secretion','P','Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell.','2013-10-27','NSRP'),(16013,32339,'negative regulation of inhibin secretion','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell.','2013-10-27','NSRP'),(16014,32340,'positive regulation of inhibin secretion','P','Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell.','2013-10-27','NSRP'),(16015,32341,'aldosterone metabolic process','P','The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.','2013-10-27','NSRP'),(16016,32342,'aldosterone biosynthetic process','P','The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.','2013-10-27','NSRP'),(16017,32343,'aldosterone catabolic process','P','The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.','2013-10-27','NSRP'),(16018,32344,'regulation of aldosterone metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone.','2013-10-27','NSRP'),(16019,32345,'negative regulation of aldosterone metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone.','2013-10-27','NSRP'),(16020,32346,'positive regulation of aldosterone metabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone.','2013-10-27','NSRP'),(16021,32347,'regulation of aldosterone biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.','2013-10-27','NSRP'),(16022,32348,'negative regulation of aldosterone biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.','2013-10-27','NSRP'),(16023,32349,'positive regulation of aldosterone biosynthetic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.','2013-10-27','NSRP'),(16024,32350,'regulation of hormone metabolic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone.','2013-10-27','NSRP'),(16025,32351,'negative regulation of hormone metabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone.','2013-10-27','NSRP'),(16026,32352,'positive regulation of hormone metabolic process','P','Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone.','2013-10-27','NSRP'),(16027,32353,'negative regulation of hormone biosynthetic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.','2013-10-27','NSRP'),(16028,32354,'response to follicle-stimulating hormone stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.','2013-10-27','NSRP'),(16029,32355,'response to estradiol stimulus','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.','2013-10-27','NSRP'),(16030,32356,'oxidized DNA binding','F','Interacting selectively and non-covalently with oxidized residues in DNA.','2013-10-27','NSRP'),(16031,32357,'oxidized purine DNA binding','F','Interacting selectively and non-covalently with oxidized purine residues in DNA.','2013-10-27','NSRP'),(16032,32358,'oxidized pyrimidine DNA binding','F','Interacting selectively and non-covalently with oxidized pyrimidine residues in DNA.','2013-10-27','NSRP'),(16033,32359,'provirus excision','P','The molecular events that lead to the excision of a viral genome from the host genome.','2013-10-27','NSRP'),(16034,32360,'provirus maintenance','P','The molecular events that maintain a viral genome integrated into a host genome.','2012-03-14','NSRP'),(16035,32361,'pyridoxal phosphate catabolic process','P','The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.','2013-10-27','NSRP'),(16036,32362,'FAD catabolic process','P','The chemical reactions and pathways resulting in the breakdown of FAD, the oxidized form of flavin-adenine dinucleotide.','2013-10-27','NSRP'),(16037,32363,'FMN catabolic process','P','The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5\'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase.','2013-10-27','NSRP'),(16038,32364,'oxygen homeostasis','P','A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell.','2013-10-27','NSRP'),(16039,32365,'intracellular lipid transport','P','The directed movement of lipids within cells.','2013-10-27','NSRP'),(16040,32366,'intracellular sterol transport','P','The directed movement of sterols within cells.','2013-10-27','NSRP'),(16041,32367,'intracellular cholesterol transport','P','The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells.','2013-10-27','NSRP'),(16042,32368,'regulation of lipid transport','P','Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16043,32369,'negative regulation of lipid transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16044,32370,'positive regulation of lipid transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16045,32371,'regulation of sterol transport','P','Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16046,32372,'negative regulation of sterol transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16047,32373,'positive regulation of sterol transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16048,32374,'regulation of cholesterol transport','P','Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16049,32375,'negative regulation of cholesterol transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16050,32376,'positive regulation of cholesterol transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16051,32377,'regulation of intracellular lipid transport','P','Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.','2013-10-27','NSRP'),(16052,32378,'negative regulation of intracellular lipid transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells.','2013-10-27','NSRP'),(16053,32379,'positive regulation of intracellular lipid transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells.','2013-10-27','NSRP'),(16054,32380,'regulation of intracellular sterol transport','P','Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells.','2013-10-27','NSRP'),(16055,32381,'negative regulation of intracellular sterol transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells.','2013-10-27','NSRP'),(16056,32382,'positive regulation of intracellular sterol transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells.','2013-10-27','NSRP'),(16057,32383,'regulation of intracellular cholesterol transport','P','Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells.','2013-10-27','NSRP'),(16058,32384,'negative regulation of intracellular cholesterol transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells.','2013-10-27','NSRP'),(16059,32385,'positive regulation of intracellular cholesterol transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells.','2013-10-27','NSRP'),(16060,32386,'regulation of intracellular transport','P','Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.','2013-10-27','NSRP'),(16061,32387,'negative regulation of intracellular transport','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.','2013-10-27','NSRP'),(16062,32388,'positive regulation of intracellular transport','P','Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.','2013-10-27','NSRP'),(16063,32389,'MutLalpha complex','C','A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.','2013-10-27','NSRP'),(16064,32390,'MutLbeta complex','C','A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1.','2013-10-27','NSRP'),(16065,32391,'photoreceptor connecting cilium','C','A nonmotile primary cilium that has a 9+0 microtubule array and forms the portion of the axoneme traversing the boundary between the photoreceptor inner and outer segments.','2013-10-27','NSRP'),(16066,32392,'DNA geometric change','P','The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.','2013-10-27','NSRP'),(16067,32393,'MHC class I receptor activity','F','Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.','2013-10-27','NSRP'),(16068,32394,'MHC class Ib receptor activity','F','Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.','2013-10-27','NSRP'),(16069,32395,'MHC class II receptor activity','F','Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.','2013-10-27','NSRP'),(16070,32396,'inhibitory MHC class I receptor activity','F','Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte.','2013-10-27','NSRP'),(16071,32397,'activating MHC class I receptor activity','F','Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte.','2013-10-27','NSRP'),(16072,32398,'MHC class Ib protein complex','C','A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.','2013-10-27','NSRP'),(16073,32399,'HECT domain binding','F','Interacting selectively and non-covalently with a HECT, \'Homologous to the E6-AP Carboxyl Terminus\', domain of a protein.','2013-10-27','NSRP'),(16074,32400,'melanosome localization','P','Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell.','2013-10-27','NSRP'),(16075,32401,'establishment of melanosome localization','P','The directed movement of a melanosome to a specific location.','2013-10-27','NSRP'),(16076,32402,'melanosome transport','P','The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.','2013-10-27','NSRP'),(16077,32403,'protein complex binding','F','Interacting selectively and non-covalently with any protein complex (a complex of two or more proteins that may include other nonprotein molecules).','2013-10-27','NSRP'),(16078,32404,'mismatch repair complex binding','F','Interacting selectively and non-covalently with a mismatch repair complex.','2013-10-27','NSRP'),(16079,32405,'MutLalpha complex binding','F','Interacting selectively and non-covalently with the mismatch repair complex MutLalpha.','2013-10-27','NSRP'),(16080,32406,'MutLbeta complex binding','F','Interacting selectively and non-covalently with the mismatch repair complex MutLbeta.','2013-10-27','NSRP'),(16081,32407,'MutSalpha complex binding','F','Interacting selectively and non-covalently with the mismatch repair complex MutSalpha.','2013-10-27','NSRP'),(16082,32408,'MutSbeta complex binding','F','Interacting selectively and non-covalently with the mismatch repair complex MutSbeta.','2013-10-27','NSRP'),(16083,32409,'regulation of transporter activity','P','Any process that modulates the activity of a transporter.','2013-10-27','NSRP'),(16084,32410,'negative regulation of transporter activity','P','Any process that stops or reduces the activity of a transporter.','2013-10-27','NSRP'),(16085,32411,'positive regulation of transporter activity','P','Any process that activates or increases the activity of a transporter.','2013-10-27','NSRP'),(16086,32412,'regulation of ion transmembrane transporter activity','P','Any process that modulates the activity of an ion transporter.','2013-10-27','NSRP'),(16087,32413,'negative regulation of ion transmembrane transporter activity','P','Any process that stops or reduces the activity of an ion transporter.','2013-10-27','NSRP'),(16088,32414,'positive regulation of ion transmembrane transporter activity','P','Any process that activates or increases the activity of an ion transporter.','2013-10-27','NSRP'),(16089,32415,'regulation of sodium:hydrogen antiporter activity','P','Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).','2013-10-27','NSRP'),(16090,32416,'negative regulation of sodium:hydrogen antiporter activity','P','Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).','2013-10-27','NSRP'),(16091,32417,'positive regulation of sodium:hydrogen antiporter activity','P','Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).','2013-10-27','NSRP'),(16092,32418,'lysosome localization','P','Any process in which a lysosome is transported to, and/or maintained in, a specific location.','2013-10-27','NSRP'),(16093,32419,'extrinsic to lysosome membrane','C','Loosely bound to one surface of the lysosome membrane, but not integrated into the hydrophobic region.','2013-10-27','NSRP'),(16094,32420,'stereocilium','C','An actin-based protrusion from the apical surface of auditory and vestibular hair cells. Bundles of stereocilia act as mechanosensory organelles.','2013-10-27','NSRP'),(16095,32421,'stereocilium bundle','C','An actin-based, cross-linked cellular protrusion on the apical surface of auditory and vestibular hair cells. Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.','2013-10-27','NSRP'),(16096,32422,'purine-rich negative regulatory element binding','F','Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.','2013-10-27','NSRP'),(16097,32423,'regulation of mismatch repair','P','Any process that modulates the frequency, rate or extent of mismatch repair.','2013-10-27','NSRP'),(16098,32424,'negative regulation of mismatch repair','P','Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair.','2013-10-27','NSRP'),(16099,32425,'positive regulation of mismatch repair','P','Any process that activates or increases the frequency, rate or extent of mismatch repair.','2013-10-27','NSRP'),(16100,32426,'stereocilium bundle tip','C','The end of a stereocilium bundle, distal to the site of the bundle\'s attachment to the apical cell surface.','2013-10-27','NSRP'),(16101,32427,'GBD domain binding','F','Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.','2013-10-27','NSRP'),(16102,32428,'beta-N-acetylgalactosaminidase activity','F','Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides.','2013-10-27','NSRP'),(16103,32429,'regulation of phospholipase A2 activity','P','Any process that modulates the activity of the enzyme phospholipase A2.','2013-10-27','NSRP'),(16104,32430,'positive regulation of phospholipase A2 activity','P','Any process that activates or increases the activity of the enzyme phospholipase A2.','2013-10-27','NSRP'),(16105,32431,'activation of phospholipase A2 activity','P','Any process that initiates the activity of the inactive enzyme phospholipase A2.','2013-10-27','NSRP'),(16106,32432,'actin filament bundle','C','An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.','2013-10-27','NSRP'),(16107,32433,'filopodium tip','C','The end of a filopodium distal to the body of the cell.','2013-10-27','NSRP'),(16108,32434,'regulation of proteasomal ubiquitin-dependent protein catabolic process','P','Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.','2013-10-27','NSRP'),(16109,32435,'negative regulation of proteasomal ubiquitin-dependent protein catabolic process','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.','2013-10-27','NSRP'),(16110,32436,'positive regulation of proteasomal ubiquitin-dependent protein catabolic process','P','Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.','2013-10-27','NSRP'),(16111,32437,'cuticular plate','C','A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.','2013-10-27','NSRP'),(16112,32438,'melanosome organization','P','A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.','2013-10-27','NSRP'),(16113,32439,'endosome localization','P','Any process in which endosomes are transported to, and/or maintained in, a specific location within the cell.','2013-10-27','NSRP'),(16114,32440,'2-alkenal reductase [NAD(P)] activity','F','Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+.','2013-10-27','NSRP'),(16115,32441,'pheophorbide a oxygenase activity','F','Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O.','2013-10-27','NSRP'),(16116,32442,'phenylcoumaran benzylic ether reductase activity','F','Catalysis of the NADPH-dependent 7-O-4\' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+.','2013-10-27','NSRP'),(16117,32443,'regulation of ergosterol biosynthetic process','P','Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.','2013-10-27','NSRP'),(16118,32444,'activin responsive factor complex','C','A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.','2013-10-27','NSRP'),(16119,32445,'fructose import','P','The directed movement of the hexose monosaccharide fructose into a cell or organelle.','2013-10-27','NSRP'),(16120,32446,'protein modification by small protein conjugation','P','A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.','2013-10-27','NSRP'),(16121,32447,'protein urmylation','P','Covalent attachment of the ubiquitin-like protein URM1 to another protein.','2013-10-27','NSRP'),(16122,32448,'DNA hairpin binding','F','Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences.','2013-10-27','NSRP'),(16123,32449,'CBM complex','C','A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation.','2013-10-27','NSRP'),(16124,32450,'maltose alpha-glucosidase activity','F','Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose.','2013-10-27','NSRP'),(16125,32451,'demethylase activity','F','Catalysis of the removal of a methyl group from a substrate.','2013-10-27','NSRP'),(16126,32452,'histone demethylase activity','F','Catalysis of the removal of a methyl group from a histone.','2013-10-27','NSRP'),(16127,32453,'histone demethylase activity (H3-K4 specific)','F','Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein.','2013-10-27','NSRP'),(16128,32454,'histone demethylase activity (H3-K9 specific)','F','Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.','2013-10-27','NSRP'),(16129,32455,'nerve growth factor processing','P','The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor.','2013-10-27','NSRP'),(16130,32456,'endocytic recycling','P','The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.','2013-10-27','NSRP'),(16131,32457,'fast endocytic recycling','P','The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport.','2013-10-27','NSRP'),(16132,32458,'slow endocytic recycling','P','The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport.','2013-10-27','NSRP'),(16133,32459,'regulation of protein oligomerization','P','Any process that modulates the frequency, rate or extent of protein oligomerization.','2013-10-27','NSRP'),(16134,32460,'negative regulation of protein oligomerization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization.','2013-10-27','NSRP'),(16135,32461,'positive regulation of protein oligomerization','P','Any process that activates or increases the frequency, rate or extent of protein oligomerization.','2013-10-27','NSRP'),(16136,32462,'regulation of protein homooligomerization','P','Any process that modulates the frequency, rate or extent of protein homooligomerization.','2013-10-27','NSRP'),(16137,32463,'negative regulation of protein homooligomerization','P','Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization.','2013-10-27','NSRP'),(16138,32464,'positive regulation of protein homooligomerization','P','Any process that activates or increases the frequency, rate or extent of protein homooligomerization.','2013-10-27','NSRP'),(16139,32465,'regulation of cytokinesis','P','Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.','2013-10-27','NSRP'),(16140,32466,'negative regulation of cytokinesis','P','Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.','2013-10-27','NSRP'),(16141,32467,'positive regulation of cytokinesis','P','Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.','2013-10-27','NSRP'),(16142,32468,'Golgi calcium ion homeostasis','P','Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings.','2013-10-27','NSRP'),(16143,32469,'endoplasmic reticulum calcium ion homeostasis','P','Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.','2013-10-27','NSRP'),(16144,32470,'elevation of endoplasmic reticulum calcium ion concentration','P','Any process that increases the concentration of calcium ions in the endoplasmic reticulum.','2013-10-27','NSRP'),(16145,32471,'reduction of endoplasmic reticulum calcium ion concentration','P','Any process that decreases the concentration of calcium ions in the endoplasmic reticulum.','2013-10-27','NSRP'),(16146,32472,'Golgi calcium ion transport','P','The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus.','2013-10-27','NSRP'),(16147,32473,'external side of mitochondrial outer membrane','C','The external (cytoplasmic) face of the mitochondrial outer membrane.','2013-10-27','NSRP'),(16148,32474,'otolith morphogenesis','P','The process in which the anatomical structures of an otolith are generated and organized.','2013-10-27','NSRP'),(16149,32475,'otolith formation','P','The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts.','2013-10-27','NSRP'),(16150,32476,'decaprenyl diphosphate synthase complex','C','A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis.','2013-10-27','NSRP'),(16151,32477,'homodimeric decaprenyl diphosphate synthase complex','C','A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis.','2013-10-27','NSRP'),(16152,32478,'heterotetrameric decaprenyl diphosphate synthase complex','C','A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1.','2013-10-27','NSRP'),(16153,32479,'regulation of type I interferon production','P','Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.','2013-10-27','NSRP'),(16154,32480,'negative regulation of type I interferon production','P','Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.','2013-10-27','NSRP'),(16155,32481,'positive regulation of type I interferon production','P','Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.','2013-10-27','NSRP'),(16156,32482,'Rab protein signal transduction','P','A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.','2013-10-27','NSRP'),(16157,32483,'regulation of Rab protein signal transduction','P','Any process that modulates the frequency, rate or extent of Rab protein signal transduction.','2013-10-27','NSRP'),(16158,32484,'Ral protein signal transduction','P','A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.','2013-10-27','NSRP'),(16159,32485,'regulation of Ral protein signal transduction','P','Any process that modulates the frequency, rate or extent of Ral protein signal transduction.','2013-10-27','NSRP'),(16160,32486,'Rap protein signal transduction','P','A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.','2013-10-27','NSRP'),(16161,32487,'regulation of Rap protein signal transduction','P','Any process that modulates the frequency, rate or extent of Rap protein signal transduction.','2013-10-27','NSRP'),(16162,32488,'Cdc42 protein signal transduction','P','A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.','2013-10-27','NSRP'),(16163,32489,'regulation of Cdc42 protein signal transduction','P','Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction.','2013-10-27','NSRP'),(16164,32490,'detection of molecule of bacterial origin','P','The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal.','2013-10-27','NSRP'),(16165,32491,'detection of molecule of fungal origin','P','The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal.','2013-10-27','NSRP'),(16166,32492,'detection of molecule of oomycetes origin','P','The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal.','2013-10-27','NSRP'),(16167,32493,'response to bacterial lipoprotein','P','Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus.','2013-10-27','NSRP'),(16168,32494,'response to peptidoglycan','P','Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.','2013-10-27','NSRP'),(16169,32495,'response to muramyl dipeptide','P','Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.','2013-10-27','NSRP'),(16170,32496,'response to lipopolysaccharide','P','Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.','2013-10-27','NSRP'),(16171,32497,'detection of lipopolysaccharide','P','The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.','2013-10-27','NSRP'),(16172,32498,'detection of muramyl dipeptide','P','The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan.','2013-10-27','NSRP'),(16173,32499,'detection of peptidoglycan','P','The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule.','2013-10-27','NSRP'),(16174,32500,'muramyl dipeptide binding','F','Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan.','2013-10-27','NSRP'),(16175,32501,'multicellular organismal process','P','Any biological process, occurring at the level of a multicellular organism, pertinent to its function.','2013-10-27','NSRP'),(16176,32502,'developmental process','P','A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.','2013-10-27','NSRP'),(16177,32504,'multicellular organism reproduction','P','The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.','2013-10-27','NSRP'),(16178,32505,'reproduction of a single-celled organism','P','The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.','2013-10-27','NSRP'),(16179,32506,'cytokinetic process','P','A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).','2013-10-27','NSRP'),(16180,32507,'maintenance of protein location in cell','P','Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.','2013-10-27','NSRP'),(16181,32508,'DNA duplex unwinding','P','The process in which interchain hydrogen bonds between two strands of DNA are broken or \'melted\', generating a region of unpaired single strands.','2013-10-27','NSRP'),(16182,32509,'endosome transport via multivesicular body sorting pathway','P','The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.','2013-10-27','NSRP'),(16183,32510,'endosome to lysosome transport via multivesicular body sorting pathway','P','The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.','2013-10-27','NSRP'),(16184,32511,'late endosome to vacuole transport via multivesicular body sorting pathway','P','The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.','2013-10-27','NSRP'),(16185,32512,'regulation of protein phosphatase type 2B activity','P','Any process that modulates the activity of the enzyme protein phosphatase type 2B.','2013-10-27','NSRP'),(16186,32513,'negative regulation of protein phosphatase type 2B activity','P','Any process that stops or reduces the activity of the enzyme protein phosphatase type 2B.','2013-10-27','NSRP'),(16187,32514,'positive regulation of protein phosphatase type 2B activity','P','Any process that activates or increases the activity of the enzyme protein phosphatase type 2B.','2013-10-27','NSRP'),(16188,32515,'negative regulation of phosphoprotein phosphatase activity','P','Any process that stops or reduces the activity of a phosphoprotein phosphatase.','2013-10-27','NSRP'),(16189,32516,'positive regulation of phosphoprotein phosphatase activity','P','Any process that activates or increases the activity of a phosphoprotein phosphatase.','2013-10-27','NSRP'),(16190,32517,'SOD1-calcineurin complex','C','A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1.','2013-10-27','NSRP'),(16191,32518,'amino acid-exporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(in) -> ADP + phosphate + amino acid(out).','2013-10-27','NSRP'),(16192,32519,'cysteine-exporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(in) -> ADP + phosphate + cysteine(out).','2013-10-27','NSRP'),(16193,32520,'amino acid-importing ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out) -> ADP + phosphate + amino acid(in).','2013-10-27','NSRP'),(16194,32521,'D-methionine-exporting ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(in) -> ADP + phosphate + D-methionine(out).','2013-10-27','NSRP'),(16195,32522,'D-methionine-importing ATPase activity','F','Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out) -> ADP + phosphate + D-methionine(in).','2013-10-27','NSRP'),(16196,32523,'silicon efflux transmembrane transporter activity','F','Catalysis of the transfer of silicon from the inside of the cell to the outside of the cell across a membrane.','2013-10-27','NSRP'),(16197,32524,'nutrient export','P','OBSOLETE. The directed movement of nutrients out of a cell or organelle.','2013-10-27','NSRP'),(16198,32525,'somite rostral/caudal axis specification','P','The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.','2013-10-27','NSRP'),(16199,32526,'response to retinoic acid','P','Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.','2013-10-27','NSRP'),(16200,32527,'protein exit from endoplasmic reticulum','P','The directed movement of proteins from the endoplasmic reticulum.','2013-10-27','NSRP'),